The 2d visualization can become twisted into configurations that look correct at first glance, but are actually reversed.
In these screenshots, the right right half of bipyridine is actually upside down. Notice how the selected atom in the 2d visualization corresponds to the selected atom in the 3d visualization in the first screenshot, but in the second one it's on the wrong side:


The 2d visualization can become twisted into configurations that look correct at first glance, but are actually reversed.
In these screenshots, the right right half of bipyridine is actually upside down. Notice how the selected atom in the 2d visualization corresponds to the selected atom in the 3d visualization in the first screenshot, but in the second one it's on the wrong side:

