diff --git a/dot_plot/README.md b/dot_plot/README.md index 4648496..84d05db 100644 --- a/dot_plot/README.md +++ b/dot_plot/README.md @@ -1,5 +1,5 @@ # MAVISp dot plot -*Last updated*: 12/02/26 +*Last updated*: 27/05/26 ## Description @@ -27,14 +27,15 @@ It produces: ``` python dot_plot.py [-h] -i INPUT [-v CLINVAR_DICTIONARY] [-o OUTPUT] [-m MUTATIONS [MUTATIONS ...]] [-r RESIDUES [RESIDUES ...]] - [-R REVEL_THRESHOLD] [-D DEMASK_THRESHOLD] - [-G GEMME_THRESHOLD] [-x X_LIM] [-f FIGSIZE FIGSIZE] - [-pltR] [-pltD] + [-R REVEL_THRESHOLD] [-P POPEVE_THRESHOLD] + [-D DEMASK_THRESHOLD] [-G GEMME_THRESHOLD] + [-x X_LIM] [-f FIGSIZE FIGSIZE] + [-pltR] [-pltP] [-pltD] [-pltC {all,uncertain,benign,likely_benign,pathogenic,likely_pathogenic,conflicting} [{all,uncertain,benign,likely_benign,pathogenic,likely_pathogenic,conflicting} ...]] [-colC] [-pltS {saturation,cosmic,cbioportal} [{saturation,cosmic,cbioportal} ...]] - [-vep {none,alphamissense,revel,gemme,eve}] + [-vep {none,alphamissense,revel,gemme,eve,popeve}] [-lgof] ``` @@ -44,16 +45,18 @@ python dot_plot.py [-h] -i INPUT [-v CLINVAR_DICTIONARY] [-o OUTPUT] - `-m/--mutations`: comma-separated mutations to display (e.g. `A4G,F55K`). Mutually exclusive with `-r`. - `-r/--residues`: comma-separated residue positions to display (e.g. `4,55`). Mutually exclusive with `-m`. - `-R/--revel_threshold`: REVEL pathogenic threshold (default: `0.5`). +- `-P/--popeve_threshold`: popEVE deleterious threshold (default: `-4.617`). - `-D/--demask_threshold`: DeMaSk delta-fitness threshold for LoF/GoF calls (default: `0.25`). - `-G/--gemme_threshold`: GEMME threshold (default: `-3.0`). - `-x/--x_lim`: number of mutations per panel before splitting across multiple figures (default: `50`). - `-f/--figsize`: figure width and height (default: `14 5`). The default works well for ~50 mutations and 7–8 labels. - `-pltR/--plot_Revel`: add REVEL classifications to the dot plot. +- `-pltP/--plot_popEVE`: add popEVE classifications to the dot plot. - `-pltD/--plot_Demask`: add DeMaSk predicted consequence (LoF/GoF) for mutations meeting the `-D` threshold. - `-pltC/--plot_Clinvar`: filter to specific ClinVar categories (e.g. `pathogenic uncertain`). Requires `dictionary.csv`. - `-colC/--color_Clinvar`: colour the x-axis labels according to ClinVar categories. Requires `dictionary.csv`. - `-pltS/--plot_Source`: filter mutations by source (`saturation`, `cosmic`, `cbioportal`). Multiple sources can be provided; filters are additive with `-pltC`. -- `-vep/--vep-filter`: restrict `mechanistic_indicators_out.csv` to mutations predicted as pathogenic by the selected VEP. Choices are `alphamissense`, `revel`, `gemme`, `eve`, or `none` (default). Supplying `-vep` without an argument defaults to `alphamissense`. +- `-vep/--vep-filter`: restrict `mechanistic_indicators_out.csv` to mutations predicted as pathogenic by the selected VEP. Choices are `alphamissense`, `revel`, `gemme`, `eve`, `popeve`, or `none` (default). Supplying `-vep` without an argument defaults to `alphamissense`. - `-lgof/--vep-filter-lgof`: when set, only keep entries classified as DeMaSk LoF or GoF in `mechanistic_indicators_out.csv`. By default, this filtering is not performed. ## MAVISp dot plot v2: @@ -78,6 +81,8 @@ In addition to all existing `dot_plot.py` options, the following differences app - potential - unknown +- popEVE support is only available in `dot_plot_v2.py`. + ## Example See the `examples` directory and the accompanying `do.sh` scripts for a minimal end-to-end run. @@ -86,7 +91,7 @@ See the `examples` directory and the accompanying `do.sh` scripts for a minimal Running the script produces: - `dot_plot.pdf` (and additional numbered PDFs if more mutations exceed `-x`). PNGs are also written when any of `-m`, `-r`, `-pltS`, or `-pltC` is used. -- `log.txt`, summarising how many variants satisfy each classifier (REVEL, GEMME, DeMaSk, EVE, AlphaMissense) and providing module-level counts. +- `log.txt`, summarising how many variants satisfy each classifier (REVEL, GEMME, DeMaSk, EVE, AlphaMissense, popEVE) and providing module-level counts. - `mechanistic_indicators_out.csv`, containing the filtered subset of mutations with at least one module effect and the consolidated `MAVISp Effects` column. This file honours all filters applied through `-m`, `-r`, `-pltS`, `-pltC`, `-vep`, and `-lgof`. Notes: diff --git a/dot_plot/dot_plot_v2.py b/dot_plot/dot_plot_v2.py index 3c6c43d..463f743 100755 --- a/dot_plot/dot_plot_v2.py +++ b/dot_plot/dot_plot_v2.py @@ -285,8 +285,8 @@ def get_clinvar_columns(df, clinvar_class_type: str): raise ValueError(f"ClinVar mode '{clinvar_class_type}' requested, but the corresponding columns are missing.") -def process_input(full_df, r_cutoff, d_cutoff, g_cutoff, residues, mutations, - clinvar_dict, plot_Revel, plot_Demask, plot_Source, plot_Clinvar, color_Clinvar, clinvar_cols): +def process_input(full_df, r_cutoff, p_cutoff, d_cutoff, g_cutoff, residues, mutations, + clinvar_dict, plot_Revel, plot_popEVE, plot_Demask, plot_Source, plot_Clinvar, color_Clinvar, clinvar_cols): ''' Read MAVISp aggregated table. The function takes as input a MAVISp csv file and returns @@ -351,6 +351,7 @@ def process_input(full_df, r_cutoff, d_cutoff, g_cutoff, residues, mutations, 'AlloSigMA 2 predicted consequence - pockets and interfaces' in x or \ ('AlloSigMA2-PSN classification' in x and not 'AlloSigMA 2 mutation type' in x) or\ 'PTM effect in ' in x or 'REVEL score' in x or \ + 'popEVE score' in x or \ 'EVE classification (25% Uncertain)' in x or \ 'DeMaSk delta fitness' in x or \ 'DeMaSk predicted consequence' in x or \ @@ -378,12 +379,25 @@ def process_input(full_df, r_cutoff, d_cutoff, g_cutoff, residues, mutations, for d in [df, full_df]: d['REVEL score'] = d['REVEL score'].apply(convert_to_float) + # Convert popEVE score column to numeric values. + # Invalid/non-numeric values are converted to NaN. + if 'popEVE score' in d.columns: + d['popEVE score'] = pd.to_numeric(d['popEVE score'], errors='coerce') + # Add REVEL score interpretation column df['REVEL'] = np.where(df['REVEL score'].isna(), None, np.where(df['REVEL score'] >= r_cutoff, 'Damaging', 'Neutral')) + try: + # Add popEVE score interpretation column + df['popEVE'] = np.where(df['popEVE score'].isna(), None, + np.where(df['popEVE score'] < p_cutoff, + 'Damaging', 'Neutral')) + except: + log.warning(f'- no popEVE found in MAVISp csv.') + try: # Convert GEMME score into absolute value df['GEMME predicted consequence'] = np.where( @@ -400,12 +414,17 @@ def process_input(full_df, r_cutoff, d_cutoff, g_cutoff, residues, mutations, 'Neutral'))) # Drop score columns + score_cols_to_drop = ['REVEL score', + 'DeMaSk delta fitness'] + if 'GEMME Score' in df.columns: - df.drop(columns = ['REVEL score','DeMaSk delta fitness', 'GEMME Score'], - inplace = True) - else: - df.drop(columns = ['REVEL score','DeMaSk delta fitness'], - inplace = True) + score_cols_to_drop.append('GEMME Score') + + if 'popEVE score' in df.columns: + score_cols_to_drop.append('popEVE score') + + df.drop(columns=score_cols_to_drop, inplace=True) + # Sort columns based on broad effect categories functional_cols = [col for col in df.columns if 'functional' in col.lower() and 'experimental data classification' not in col.lower()] @@ -468,7 +487,8 @@ def process_input(full_df, r_cutoff, d_cutoff, g_cutoff, residues, mutations, 'AlphaMissense classification', 'EVE classification (25% Uncertain)', 'GEMME predicted consequence', - 'REVEL' + 'REVEL', + 'popEVE' ] demask_pred_col = 'DeMaSk predicted consequence' experimental_present = [col for col in experimental_cols if col in df.columns] @@ -669,6 +689,9 @@ def process_input(full_df, r_cutoff, d_cutoff, g_cutoff, residues, mutations, if not plot_Revel and 'REVEL' in plot_df.columns: plot_df = plot_df.drop(columns=['REVEL']) + if not plot_popEVE and 'popEVE' in plot_df.columns: + plot_df = plot_df.drop(columns=['popEVE']) + if not plot_Demask and 'DeMaSk predicted consequence' in plot_df.columns: plot_df = plot_df.drop(columns=['DeMaSk predicted consequence']) @@ -882,7 +905,7 @@ def plot(df, full_df, width, height, xlim, clinvar_flag, clinvar_class_type, cli return figures -def generate_summary(data,d_cutoff,r_cutoff, clinvar_cols): +def generate_summary(data,d_cutoff,r_cutoff, p_cutoff, clinvar_cols): ''' Summary log.txt file. The function is aimed at summarizing the number of mutations @@ -1566,6 +1589,18 @@ def generate_summary(data,d_cutoff,r_cutoff, clinvar_cols): f'which could be of interest for further investigation:\n' out += f'-- {revel_d}\n' + # popEVE score < -4.617 (default) + try: + popeve_d = data_d.index[data_d['popEVE score'] < p_cutoff].to_list() + + out += f'- We aggregated all the variants that have at least one of the MAVISp modules ' \ + f'with a predicted damaging effect (except for PTM.function) and retained only ' \ + f'the ones with a popEVE score < {p_cutoff} for a total of {len(popeve_d)} variants ' \ + f'which could be of interest for further investigation:\n' + out += f'-- {popeve_d}\n' + except KeyError: + out += '\n- popEVE score not available.\n' + # Demask demask_d = data_d.index[(data_d['DeMaSk delta fitness'] >= d_cutoff) | (data_d['DeMaSk delta fitness'] <= -d_cutoff)].to_list() out += f'- We aggregated all the variants that have at least one of the MAVISp modules ' \ @@ -1900,6 +1935,8 @@ def filter_vep_summary(summary, df, vep_filter, glof_filter): filtered_index_vep = df[df['REVEL'] == 1].index elif vep_filter == 'eve': filtered_index_vep = df[df['EVE classification (25% Uncertain)'] == 1].index + elif vep_filter == 'popeve': + filtered_index_vep = df[df['popEVE'] == 1].index elif vep_filter == 'none': filtered_index_vep = df.index @@ -1981,6 +2018,14 @@ def main(): type = float, help = R_helpstr) + P_default = -4.617 + P_helpstr = f"Threshold to classify a mutation according to the " \ + f"popEVE score. (Default = {P_default})" + parser.add_argument("-P", "--popeve_threshold", + default=P_default, + type=float, + help=P_helpstr) + D_default = 0.25 D_helpstr = f"Threshold to classify a mutation according to the " \ f"DeMask score. (Default = {D_default})" @@ -2021,12 +2066,18 @@ def main(): action = 'store_true', help = pltR_helpstr) + pltP_helpstr = f"Plotting of popEVE classification. (Default = None)" + parser.add_argument("-pltP", "--plot_popEVE", + action='store_true', + help=pltP_helpstr) + pltD_helpstr = f"Plotting of Demask LoF/GoF if" \ f" mutation is above demask threshold. " \ f"(Default = None)" parser.add_argument("-pltD", "--plot_Demask", action = 'store_true', help = pltD_helpstr) + clinvarclasstype_helpstr = f"ClinVar classification type to use for plotting/coloring. " \ f"Choices:aggregated, germline, oncogenicity, clinical_impact." parser.add_argument("-cct", "--clinvar_class_type", @@ -2077,10 +2128,10 @@ def main(): help = pltS_helpstr) AMx_helpstr = "Restrict mechanisitc indicators output to pathogenic variants. Choose the VEP to use" \ - "to detect pathogenic variants between none, alphamissense, revel, gemme, eve. If this option" \ + "to detect pathogenic variants between none, alphamissense, revel, gemme, eve, popeve. If this option" \ "is used without argument it will default to alphamissense" parser.add_argument("-vep", "--vep-filter", - choices=["none", "alphamissense", "revel", "gemme", "eve"], + choices=["none", "alphamissense", "revel", "gemme", "eve", "popeve"], nargs="?", const="alphamissense", default="none", @@ -2167,12 +2218,14 @@ def main(): try: plot_df, classification_df, dataframe, clinvar_mapped_df = process_input(full_df = full_df, r_cutoff = args.revel_threshold, + p_cutoff=args.popeve_threshold, d_cutoff = args.demask_threshold, g_cutoff= args.gemme_threshold, residues = args.residues, mutations = args.mutations, clinvar_dict = clinvar_dict, plot_Revel = args.plot_Revel, + plot_popEVE=args.plot_popEVE, plot_Demask = args.plot_Demask, plot_Source = args.plot_Source, plot_Clinvar = args.plot_Clinvar, @@ -2192,6 +2245,7 @@ def main(): summary, summary_df = generate_summary(data = dataframe, d_cutoff = args.demask_threshold, r_cutoff = args.revel_threshold, + p_cutoff=args.popeve_threshold, clinvar_cols = clinvar_cols) out.write(summary) diff --git a/dot_plot/examples_v2/ensemble_mode_popeve/TP53-ensemble_mode.csv b/dot_plot/examples_v2/ensemble_mode_popeve/TP53-ensemble_mode.csv new file mode 100644 index 0000000..94c62c8 --- /dev/null +++ b/dot_plot/examples_v2/ensemble_mode_popeve/TP53-ensemble_mode.csv @@ -0,0 +1,3782 @@ +Mutation,HGVSp,HGVSg,gnomAD genome allele frequency,gnomAD exome allele frequency,REVEL score,Mutation sources,ClinVar Variation ID,ClinVar Germline Interpretation,ClinVar Germline Review Status,ClinVar Oncogenicity Interpretation,ClinVar Oncogenicity Review Status,ClinVar Clinical Impact Interpretation,ClinVar Clinical Impact Review Status,"Stability (FoldX5, kcal/mol) [md]","Stability (ThermoMPNN, kcal/mol) [md]","Stability (Rosetta Cartddg2020, kcal/mol) [md]","Stability (RaSP, kcal/mol) [md]","Stability (Foldetta from FoldX and Rosetta, kcal/mol) [md]","Stability (Foldetta from FoldX and RaSP, kcal/mol) [md]","Stability classification, (Rosetta, FoldX) [md]","Stability classification, (RaSP, FoldX) [md]",Stability classification (ThermoMPNN) [md],Stability classification (Foldetta from FoldX and Rosetta) [md],Stability classification (Foldetta from FoldX and RaSP) [md],"Stability (ThermoMPNN, kcal/mol, st. dev.) [md]","Stability (Rosetta Cartddg2020, kcal/mol, st. dev.) [md]","Stability (RaSP, kcal/mol, st. dev.) [md]","Stability (FoldX5, kcal/mol) [cabsflex]","Stability (Rosetta Cartddg2020, kcal/mol) [cabsflex]","Stability (RaSP, kcal/mol) [cabsflex]","Stability (Foldetta from FoldX and Rosetta, kcal/mol) [cabsflex]","Stability (Foldetta from FoldX and RaSP, kcal/mol) [cabsflex]","Stability classification, (Rosetta, FoldX) [cabsflex]","Stability classification, (RaSP, FoldX) [cabsflex]",Stability classification (Foldetta from FoldX and Rosetta) [cabsflex],Stability classification (Foldetta from FoldX and RaSP) [cabsflex],"Stability (Rosetta Cartddg2020, kcal/mol, st. dev.) [cabsflex]","Stability (RaSP, kcal/mol, st. dev.) [cabsflex]",Relative Side Chain Solvent Accessibility in wild-type (average) [md],Relative Side Chain Solvent Accessibility in wild-type (standard deviation) [md],Relative Side Chain Solvent Accessibility in wild-type (average) [cabsflex],Relative Side Chain Solvent Accessibility in wild-type (standard deviation) [cabsflex],PTMs [md],is site part of phospho-SLiM [md],PTM residue SASA (%) [md],"Change in stability with PTM (FoldX5, kcal/mol) [md]",PTM effect in regulation [md],PTM effect in stability [md],PTM effect in function [md],PTMs [cabsflex],is site part of phospho-SLiM [cabsflex],PTM residue SASA (%) [cabsflex],"Change in stability with PTM (FoldX5, kcal/mol) [cabsflex]",PTM effect in regulation [cabsflex],PTM effect in stability [cabsflex],PTM effect in function [cabsflex],AlloSigMA2-PSN classification - pockets and interfaces [md],Functional dynamics (207-213 interface) [metad],DeMaSk delta fitness,DeMaSk Shannon entropy,DeMaSk log2 variant frequency,GEMME Score,EVE score,EVE classification (25% Uncertain),AlphaMissense pathogenicity score,AlphaMissense classification,popEVE score,popEVE status,References +W91A,NP_000537:p.Trp91Ala,,,,,saturation_mutlist,,,,,,,,1.26055,0.6663064217567444,,0.4227194030693469,,0.8416347015346735,,Neutral,Neutral,,Neutral,0.1803778390526467,,0.26822333945729515,-0.08362,,0.5832177293739441,,0.24979886468697204,,Neutral,,Neutral,,0.24750172607040138,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.2593,2.4818,-4.8073,-1.21393476861276,4.478983322371786e-07,Benign,0.5809,pathogenic,-2.906,available,https://doi.org/10.1101/2022.10.22.513328 +W91C,NP_000537:p.Trp91Cys,,,,,saturation_mutlist,,,,,,,,1.09645,0.37612200260162354,1.3690499999999999,0.9481745980456667,1.2327499999999998,1.0223122990228333,Neutral,Neutral,Neutral,Neutral,Neutral,0.15083615132774897,0.7872277140700776,0.29487235544945195,-0.00274,1.7604333333333333,1.0890734956992012,0.8788466666666667,0.5431667478496006,Neutral,Neutral,Neutral,Neutral,0.6258044558450792,0.1963078968223391,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.2748,2.4818,-20.417,-0.527962776148948,0.0030173190140476,Benign,0.7778,pathogenic,-3.284,available,https://doi.org/10.1101/2022.10.22.513328 +W91D,NP_000537:p.Trp91Asp,,,,,saturation_mutlist,,,,,,,,1.26956,0.7919823813438416,,0.305939499322555,,0.7877497496612775,,Neutral,Neutral,,Neutral,0.19807166894138242,,0.4331623809656768,0.16029,,0.4190424784624677,,0.28966623923123386,,Neutral,,Neutral,,0.2842486376654584,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.2836,2.4818,-4.8073,-3.06595378250322,0.4361248909836608,Uncertain,0.914,pathogenic,-3.47,available,https://doi.org/10.1101/2022.10.22.513328 +W91E,NP_000537:p.Trp91Glu,,,,,saturation_mutlist,,,,,,,,1.12747,0.7898421812057496,,0.4441019763150553,,0.7857859881575276,,Neutral,Neutral,,Neutral,0.23377242687978325,,0.3692450407043221,0.08911,,0.5164431602456987,,0.30277658012284936,,Neutral,,Neutral,,0.33587963451709146,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.3069,2.4818,-5.5443,-1.98268418503221,0.0049803233906901,Benign,0.9253,pathogenic,-3.29,available,https://doi.org/10.1101/2022.10.22.513328 +W91F,NP_000537:p.Trp91Phe,,,,,saturation_mutlist,,,,,,,,0.58382,0.37093946695327756,,0.014027131117664701,,0.29892356555883237,,Neutral,Neutral,,Neutral,0.10608989586394471,,0.19258463876500062,0.32348,,0.4027221825085065,,0.36310109125425327,,Neutral,,Neutral,,0.16446852753322774,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.1156,2.4818,-5.5443,-2.49209955974605,0.0002906692206613,Benign,0.2249,benign,-3.225,available,https://doi.org/10.1101/2022.10.22.513328 +W91G,NP_000537:p.Trp91Gly,,,,,saturation_mutlist,,,,,,,,1.38961,0.8654311656951904,,0.7680263426075342,,1.0788181713037672,,Neutral,Neutral,,Neutral,0.22238039273653615,,0.4223873131835856,-0.51334,,0.8178434037489923,,0.15225170187449616,,Neutral,,Neutral,,0.38775196845763166,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.3241,2.4818,-20.417,-3.12913986924445,0.0374753283240779,Benign,0.4171,ambiguous,-3.281,available,https://doi.org/10.1101/2022.10.22.513328 +W91H,NP_000537:p.Trp91His,,,,,saturation_mutlist,,,,,,,,1.06212,0.5959005379676818,,-0.01656016224710403,,0.5227799188764479,,Neutral,Neutral,,Neutral,0.15980147342339418,,0.2114571871468999,0.41202,,0.12890509856096094,,0.27046254928048047,,Neutral,,Neutral,,0.23940681660149177,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.3273,2.4818,-20.417,-1.89129088279009,0.0174748545295643,Benign,0.8558,pathogenic,-3.264,available,https://doi.org/10.1101/2022.10.22.513328 +W91I,NP_000537:p.Trp91Ile,,,,,saturation_mutlist,,,,,,,,0.91083,0.598838050365448,,0.3680752708233089,,0.6394526354116544,,Neutral,Neutral,,Neutral,0.16854837184686725,,0.10519201464761205,0.14487,,0.42617244554634554,,0.28552122277317277,,Neutral,,Neutral,,0.14701260528475218,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.257,2.4818,-7.1292,-0.784314728700572,0.0002492861200903,Benign,0.5898,pathogenic,-3.165,available,https://doi.org/10.1101/2022.10.22.513328 +W91K,NP_000537:p.Trp91Lys,,,,,saturation_mutlist,,,,,,,,1.01171,0.7039675903320313,,0.5847086661977232,,0.7982093330988617,,Neutral,Neutral,,Neutral,0.20534838947545675,,0.29722609496781954,0.00352,,0.5293089100032746,,0.2664144550016373,,Neutral,,Neutral,,0.16344250276059213,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.327,2.4818,-7.1292,-3.71242629965711,0.0978694955327409,Benign,0.9641,pathogenic,-3.401,available,https://doi.org/10.1101/2022.10.22.513328 +W91L,NP_000537:p.Trp91Leu,,,,,saturation_mutlist,,,,,,,,0.68541,0.5105725193023681,,-0.21548982766402394,,0.23496008616798802,,Neutral,Neutral,,Neutral,0.15087921216386846,,0.10694939279976089,-0.21023,,-0.09826591350378223,,-0.15424795675189112,,Neutral,,Neutral,,0.11109503358775608,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.2067,2.4818,-4.8073,-0.234824387695313,1.9495371150361774e-06,Benign,0.3707,ambiguous,-2.933,available,https://doi.org/10.1101/2022.10.22.513328 +W91M,NP_000537:p.Trp91Met,,,,,saturation_mutlist,,,,,,,,0.18634,0.5326768302917481,,0.010890532864900238,,0.09861526643245012,,Neutral,Neutral,,Neutral,0.1445788423083422,,0.15969784178920493,-0.50105,,0.14711840389510558,,-0.17696579805244722,,Neutral,,Neutral,,0.14885068218125166,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.2985,2.4818,-20.417,-1.19458907253691,0.0042940757537255,Benign,0.6634,pathogenic,-3.206,available,https://doi.org/10.1101/2022.10.22.513328 +W91N,NP_000537:p.Trp91Asn,,,,,saturation_mutlist,,,,,,,,1.10519,0.6903165578842163,,0.13596959935333233,,0.6205797996766661,,Neutral,Neutral,,Neutral,0.1965790346472247,,0.2601647257234403,-0.06903,,0.2910134257399251,,0.11099171286996257,,Neutral,,Neutral,,0.18903070471176092,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.3715,2.4818,-20.417,-1.86691678346054,6.618042871131374e-05,Benign,0.8586,pathogenic,-3.128,available,https://doi.org/10.1101/2022.10.22.513328 +W91P,NP_000537:p.Trp91Pro,,,,,saturation_mutlist,,,,,,,,1.35001,0.6984735441207885,,1.4268143280947212,,1.3884121640473606,,Neutral,Neutral,,Neutral,0.18939231152858574,,0.9041829601714815,-0.00805,,0.814136754085054,,0.403043377042527,,Neutral,,Neutral,,0.490739973945214,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.33,2.4818,-4.8073,-1.41535491378381,3.004220184257384e-07,Benign,0.6349,pathogenic,-2.849,available,https://doi.org/10.1101/2022.10.22.513328 +W91Q,NP_000537:p.Trp91Gln,,,,,saturation_mutlist,,,,,,,,0.94221,0.7089150857925415,,0.4415431971843116,,0.6918765985921558,,Neutral,Neutral,,Neutral,0.18057616635694407,,0.2479995192476508,-0.17694,,0.6050699817322045,,0.21406499086610226,,Neutral,,Neutral,,0.17424052078185795,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.2827,2.4818,-4.8073,-2.27091397558982,0.0004180444582935,Benign,0.9033,pathogenic,-3.074,available,https://doi.org/10.1101/2022.10.22.513328 +W91R,NP_000537:p.Trp91Arg,"hg19,17:g.7579416A>G, hg38,17:g.7676098A>G",,,0.507,"ClinVar,saturation_mutlist",845798,Uncertain significance,1,,,,,0.95517,0.6505920124053955,1.3777766666666666,0.27077491377402135,1.1664733333333333,0.6129724568870106,Neutral,Neutral,Neutral,Neutral,Neutral,0.19529524251707212,1.409037444885298,0.24452420248825293,-0.12478,1.43288,0.3081810351520036,0.65405,0.09170051757600181,Neutral,Neutral,Neutral,Neutral,0.853419935553418,0.1247438186174978,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.3228,2.4818,-20.417,-3.32436611299892,0.0014634687722784,Benign,0.9346,pathogenic,-3.32,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +W91S,NP_000537:p.Trp91Ser,"hg19,17:g.7579415C>G, hg38,17:g.7676097C>G",,,0.485,"cBioPortal,ClinVar,saturation_mutlist",3232053,Uncertain significance,1,,,,,1.32043,0.6972148942947388,1.1112233333333332,0.29893357385096303,1.2158266666666666,0.8096817869254815,Neutral,Neutral,Neutral,Neutral,Neutral,0.19552329312285183,1.232269046821982,0.39416357287522674,0.01862,1.6682566666666665,0.5096819241259486,0.8434383333333333,0.2641509620629743,Neutral,Neutral,Neutral,Neutral,1.045881047230303,0.30672129779800444,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.248,2.4818,-2.9594,-1.25226234139329,6.558056921170282e-06,Benign,0.447,ambiguous,-2.918,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +W91T,NP_000537:p.Trp91Thr,,,,,saturation_mutlist,,,,,,,,1.2482,0.6546504068374633,,0.5114986030963845,,0.8798493015481923,,Neutral,Neutral,,Neutral,0.20323354435644933,,0.26317142746302724,0.21296,,0.5397082742648354,,0.3763341371324177,,Neutral,,Neutral,,0.19519299152659297,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.2997,2.4818,-4.5443,-1.40011306436101,1.818842508136829e-05,Benign,0.5926,pathogenic,-2.974,available,https://doi.org/10.1101/2022.10.22.513328 +W91V,NP_000537:p.Trp91Val,,,,,saturation_mutlist,,,,,,,,1.23957,0.6178939008712768,,0.4724886889689553,,0.8560293444844777,,Neutral,Neutral,,Neutral,0.17345691195206425,,0.19698608355807293,0.33285,,0.5069448876632315,,0.41989744383161576,,Neutral,,Neutral,,0.13795271748066795,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.2385,2.4818,-5.1293,-0.83720437558844,3.584732021346137e-06,Benign,0.4933,ambiguous,-3.016,available,https://doi.org/10.1101/2022.10.22.513328 +W91Y,NP_000537:p.Trp91Tyr,,,,,saturation_mutlist,,,,,,,,0.62992,0.302871310710907,,0.15532678393533259,,0.3926233919676663,,Neutral,Neutral,,Neutral,0.07744612379112044,,0.17820979157062347,0.50239,,0.5459294255689559,,0.5241597127844779,,Neutral,,Neutral,,0.12996091480388886,70.277,22.26,66.47,25.088,,True,70.277,,neutral,neutral,neutral,,True,66.47,,neutral,neutral,neutral,uncertain,,-0.1666,2.4818,-6.1292,-1.78688237164843,0.012426577193421,Benign,0.5289,ambiguous,-3.276,available,https://doi.org/10.1101/2022.10.22.513328 +P92A,NP_000537:p.Pro92Ala,"hg38,17:g.7676095G>C",,,0.509,"COSMIC,saturation_mutlist",,,,,,,,1.18621,0.9607896041870118,0.22732666666666668,0.2338675855864454,0.7067683333333333,0.7100387927932227,Neutral,Neutral,Neutral,Neutral,Neutral,0.49143353041392634,0.4192688644400975,0.10157083181329224,1.39309,0.26870666666666665,0.42651913496335836,0.8308983333333333,0.9098045674816791,Neutral,Neutral,Neutral,Neutral,0.4446418532057258,0.5422450668931156,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.1124,1.3832,-4.9818,-1.1402449252468,2.276109414306165e-06,Benign,0.1419,benign,-2.988,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P92C,NP_000537:p.Pro92Cys,,,,,saturation_mutlist,,,,,,,,1.25926,0.5575411653518677,,0.7036027541927249,,0.9814313770963625,,Neutral,Neutral,,Neutral,0.42972242721238435,,0.08825587489908114,1.6462,,1.0035182907046127,,1.3248591453523064,,Neutral,,Neutral,,0.49706753613717636,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.2247,1.3832,-20.5915,-3.3239204213933,0.6418164856825995,Uncertain,0.555,ambiguous,-3.741,available,https://doi.org/10.1101/2022.10.22.513328 +P92D,NP_000537:p.Pro92Asp,,,,,saturation_mutlist,,,,,,,,1.07135,1.4646456456184387,,0.18415026438887402,,0.627750132194437,,Neutral,Uncertain,,Neutral,0.6646074223504024,,0.4900253819495436,1.30441,,0.9824023361437595,,1.1434061680718797,,Neutral,,Neutral,,1.1434581408986388,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.2506,1.3832,-20.5915,-3.98445845286414,0.0656958959214358,Benign,0.6764,pathogenic,-3.364,available,https://doi.org/10.1101/2022.10.22.513328 +P92E,NP_000537:p.Pro92Glu,,,,,saturation_mutlist,,,,,,,,0.70781,1.1906438779830932,,0.22747875587221011,,0.4676443779361051,,Neutral,Uncertain,,Neutral,0.6087208602166837,,0.28533837734265294,1.52682,,0.9071130530157739,,1.216966526507887,,Neutral,,Neutral,,0.7693072004058352,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.1615,1.3832,-6.3037,-4.48907941538531,0.0315104970744822,Benign,0.492,ambiguous,-3.444,available,https://doi.org/10.1101/2022.10.22.513328 +P92F,NP_000537:p.Pro92Phe,,,,,saturation_mutlist,,,,,,,,1.04868,0.8571971082687377,,-0.08990062207051412,,0.479389688964743,,Neutral,Neutral,,Neutral,0.6239449847913098,,0.24729535481058115,3.0817,,-0.47382669025769447,,1.3039366548711528,,Uncertain,,Neutral,,0.3494292335252493,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.2531,1.3832,-20.5915,-4.90474620883069,0.2970402818187991,Benign,0.5921,pathogenic,-3.591,available,https://doi.org/10.1101/2022.10.22.513328 +P92G,NP_000537:p.Pro92Gly,,,,,saturation_mutlist,,,,,,,,1.68202,1.4053704738616943,,1.0211145588393131,,1.3515672794196565,,Neutral,Uncertain,,Neutral,0.6091793744977183,,0.5474913459747226,1.03349,,1.5270899508836242,,1.280289975441812,,Neutral,,Neutral,,0.7689340606716334,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.1335,1.3832,-6.3037,-3.19751384610838,0.0001534020377648,Benign,0.3719,ambiguous,-3.173,available,https://doi.org/10.1101/2022.10.22.513328 +P92H,NP_000537:p.Pro92His,"hg19,17:g.7579412G>T, hg38,17:g.7676094G>T",,,0.452,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3634435,Uncertain significance,1,,,,,1.46241,0.9627404737472535,0.1403633333333333,-0.028912863696221962,0.8013866666666667,0.716748568151889,Neutral,Neutral,Neutral,Neutral,Neutral,0.5992345661726426,0.2209731448741126,0.20218649856880147,3.21532,1.0320866666666666,-0.0911043495475189,2.1237033333333333,1.5621078252262406,Uncertain,Uncertain,Uncertain,Neutral,0.4292640413027343,0.354866648097571,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.2307,1.3832,-20.5915,-3.34022868100625,0.0201685841707549,Benign,0.3065,benign,-3.401,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P92I,NP_000537:p.Pro92Ile,,,,,saturation_mutlist,,,,,,,,1.38979,0.9388633155822754,,-0.12401711346912832,,0.6328864432654359,,Neutral,Neutral,,Neutral,0.5926256187270806,,0.4226275561538698,2.45845,,0.21026476896080096,,1.3343573844804004,,Uncertain,,Neutral,,0.3590781664360111,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.2362,1.3832,-20.5915,-3.20023373279528,0.0099517758758106,Benign,0.4249,ambiguous,-3.368,available,https://doi.org/10.1101/2022.10.22.513328 +P92K,NP_000537:p.Pro92Lys,,,,,saturation_mutlist,,,,,,,,1.05222,0.8905123209953308,,0.23811356590604904,,0.6451667829530245,,Neutral,Neutral,,Neutral,0.5253755718660043,,0.3018855273633242,2.10751,,0.856951381067835,,1.4822306905339175,,Uncertain,,Neutral,,0.703471166984593,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.2261,1.3832,-20.5915,-5.12893583928586,0.1132193516459608,Benign,0.5541,ambiguous,-3.464,available,https://doi.org/10.1101/2022.10.22.513328 +P92L,NP_000537:p.Pro92Leu,"hg19,17:g.7579412G>A, hg38,17:g.7676094G>A",,3.9932274862e-06,0.487,"COSMIC,ClinVar,saturation_mutlist",480733,Conflicting classifications of pathogenicity,1,,,,,0.9888,0.814722216129303,0.20068,-0.33508035982541967,0.59474,0.3268598200872902,Neutral,Neutral,Neutral,Neutral,Neutral,0.5428986094762364,0.4513412060367042,0.2736308067478443,1.28258,0.25748333333333334,-0.3892516665315769,0.7700316666666667,0.4466641667342116,Neutral,Neutral,Neutral,Neutral,0.12277134419544147,0.37753760257623886,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.1678,1.3832,-6.3037,-2.7413727216631,0.0016469770770584,Benign,0.186,benign,-3.211,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P92M,NP_000537:p.Pro92Met,,,,,saturation_mutlist,,,,,,,,0.84764,0.8091907572746276,,0.014966078875180996,,0.43130303943759046,,Neutral,Neutral,,Neutral,0.5262177450229693,,0.21133288959330607,1.14229,,-0.09705341682082184,,0.5226182915895891,,Neutral,,Neutral,,0.2192831247749726,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.1239,1.3832,-7.3037,-4.35965628374266,0.0050418113379245,Benign,0.4047,ambiguous,-3.609,available,https://doi.org/10.1101/2022.10.22.513328 +P92N,NP_000537:p.Pro92Asn,,,,,saturation_mutlist,,,,,,,,1.46378,1.1890959298610688,,0.008148857554765002,,0.7359644287773826,,Neutral,Uncertain,,Neutral,0.6040505611980447,,0.20979007276516048,1.78521,,0.33866453675416897,,1.0619372683770845,,Neutral,,Neutral,,0.6226723059602473,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.2187,1.3832,-20.5915,-4.182541296034,0.0030528099230972,Benign,0.4425,ambiguous,-3.407,available,https://doi.org/10.1101/2022.10.22.513328 +P92Q,NP_000537:p.Pro92Gln,,,,,saturation_mutlist,,,,,,,,1.13944,1.0328471636772156,,0.33557064744767623,,0.7375053237238381,,Neutral,Uncertain,,Neutral,0.557809391193793,,0.1864133752660332,1.91601,,0.6206794715300022,,1.268344735765001,,Neutral,,Neutral,,0.36992315786921603,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.1475,1.3832,-6.3037,-3.79800615055763,0.0659039849299627,Benign,0.2507,benign,-3.354,available,https://doi.org/10.1101/2022.10.22.513328 +P92R,NP_000537:p.Pro92Arg,,,,,saturation_mutlist,,,,,,,,1.22141,0.8851362705230713,,0.07901032746081448,,0.6502101637304073,,Neutral,Neutral,,Neutral,0.5456160206110074,,0.23195139005499382,2.58256,,0.3359350119499853,,1.4592475059749925,,Uncertain,,Neutral,,0.4449674945310163,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.2618,1.3832,-20.5915,-4.66208450595303,0.0170723778145903,Benign,0.373,ambiguous,-3.45,available,https://doi.org/10.1101/2022.10.22.513328 +P92S,NP_000537:p.Pro92Ser,"hg19,17:g.7579413G>A, hg19,17:g.7676095G>A",,,0.502,"cBioPortal,saturation_mutlist",,,,,,,,1.405,1.112872929573059,0.08084000000000001,0.3684716145210319,0.74292,0.8867358072605159,Neutral,Neutral,Uncertain,Neutral,Neutral,0.5269728950276514,0.15358100294849836,0.31633591384823134,1.68133,0.6342433333333334,0.8088373579910159,1.1577866666666667,1.245083678995508,Neutral,Neutral,Neutral,Neutral,0.48298201873591756,0.9244810841758361,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.1239,1.3832,-7.3037,-1.26628204561654,1.6759643091015722e-05,Benign,0.2002,benign,-3.008,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P92T,NP_000537:p.Pro92Thr,"hg19,17:g.7579413G>T, hg38,17:g.7676095G>T",,,0.434,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.70207,1.1614049458503723,0.03004333333333335,0.14591947144396614,0.8660566666666667,0.9239947357219831,Neutral,Neutral,Uncertain,Neutral,Neutral,0.5960176606566682,0.5172130641127396,0.13156997912418586,2.45313,0.4438766666666667,0.6705548553235229,1.4485033333333333,1.5618424276617613,Uncertain,Uncertain,Neutral,Neutral,0.8672126866512557,0.5383971587193965,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.1126,1.3832,-2.7188,-0.0844077474009532,1.578833230636274e-08,Benign,0.1425,benign,-2.867,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P92V,NP_000537:p.Pro92Val,,,,,saturation_mutlist,,,,,,,,1.3686,1.031196129322052,,-0.07333975051362446,,0.6476301247431878,,Neutral,Uncertain,,Neutral,0.5784744355555117,,0.34468146947842415,2.5353,,0.1503772465806922,,1.342838623290346,,Uncertain,,Neutral,,0.30843870455185884,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.1186,1.3832,-6.3037,-2.7433785794869,6.81786700674331e-05,Benign,0.2723,benign,-3.144,available,https://doi.org/10.1101/2022.10.22.513328 +P92W,NP_000537:p.Pro92Trp,,,,,saturation_mutlist,,,,,,,,1.23882,0.7617625093460083,,-0.2638150329742471,,0.4875024835128765,,Neutral,Neutral,,Neutral,0.6555867948593394,,0.2514060511599544,3.87197,,-0.5241989017890664,,1.673885549105467,,Uncertain,,Neutral,,0.4908880812049908,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.2656,1.3832,-20.5915,-4.90474620883069,0.4475317298130224,Uncertain,0.7573,pathogenic,-3.878,available,https://doi.org/10.1101/2022.10.22.513328 +P92Y,NP_000537:p.Pro92Tyr,,,,,saturation_mutlist,,,,,,,,1.2362,0.7441370463371277,,0.056618837468434526,,0.6464094187342172,,Neutral,Neutral,,Neutral,0.6293347798177624,,0.22106945032201644,3.44094,,-0.2612145147391927,,1.5898627426304035,,Uncertain,,Neutral,,0.3388541547922495,50.692,19.319,37.285,20.61,,True,50.692,,neutral,neutral,neutral,,True,37.285,,neutral,neutral,neutral,uncertain,,-0.2541,1.3832,-20.5915,-4.37030066074791,0.0137687591080177,Benign,0.6056,pathogenic,-3.614,available,https://doi.org/10.1101/2022.10.22.513328 +L93A,NP_000537:p.Leu93Ala,,,,,saturation_mutlist,,,,,,,,0.70847,0.10251598954200744,,1.152917401955128,,0.930693700977564,,Neutral,Neutral,,Neutral,0.2337046989153877,,0.5759913133984571,0.29097,,1.1200697535552557,,0.7055198767776278,,Neutral,,Neutral,,0.2353145645808664,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.1574,2.0195,-7.2945,-1.74360972504892,5.347517750636637e-06,Benign,0.3383,benign,-2.995,available,https://doi.org/10.1101/2022.10.22.513328 +L93C,NP_000537:p.Leu93Cys,,,,,saturation_mutlist,,,,,,,,0.66953,-0.13993661880493163,,1.5872796329033683,,1.1284048164516842,,Neutral,Neutral,,Neutral,0.06182766899906128,,0.4422447252419202,0.44544,,1.3966367116066303,,0.9210383558033152,,Neutral,,Neutral,,0.13747545863635935,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.2145,2.0195,-20.5824,-3.85931423451475,0.23759370335703,Benign,0.6666,pathogenic,-3.554,available,https://doi.org/10.1101/2022.10.22.513328 +L93D,NP_000537:p.Leu93Asp,,,,,saturation_mutlist,,,,,,,,0.61312,0.3060285925865173,,0.9160510306094153,,0.7645855153047076,,Neutral,Neutral,,Neutral,0.33744766926740877,,0.6017736136312819,0.61741,,1.0720158572268323,,0.8447129286134162,,Neutral,,Neutral,,0.06958419748149111,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.3468,2.0195,-20.5824,-3.91833103907657,0.0495214771960732,Benign,0.8585,pathogenic,-3.403,available,https://doi.org/10.1101/2022.10.22.513328 +L93E,NP_000537:p.Leu93Glu,,,,,saturation_mutlist,,,,,,,,0.27651,0.15703316926956176,,0.8109556927500939,,0.5437328463750469,,Neutral,Neutral,,Neutral,0.21742807430492977,,0.6020026017641187,0.08063,,0.9453481411981177,,0.5129890705990588,,Neutral,,Neutral,,0.16265732375430084,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.3148,2.0195,-20.5824,-2.68089126047792,0.0008992207912727,Benign,0.6405,pathogenic,-3.208,available,https://doi.org/10.1101/2022.10.22.513328 +L93F,NP_000537:p.Leu93Phe,,,,,saturation_mutlist,,,,,,,,-0.03648,0.09045662641525269,,0.5343471174218716,,0.24893355871093578,,Neutral,Neutral,,Neutral,0.11948095321006967,,0.347607270791628,0.02721,,0.2191192306395419,,0.12316461531977095,,Neutral,,Neutral,,0.04602456211502432,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,neutral,,-0.0726,2.0195,-3.7097,-4.39451215448914,0.4488436240026198,Uncertain,0.2765,benign,-3.474,available,https://doi.org/10.1101/2022.10.22.513328 +L93G,NP_000537:p.Leu93Gly,,,,,saturation_mutlist,,,,,,,,1.03352,0.366316522359848,,1.6500544347373793,,1.3417872173686898,,Neutral,Neutral,,Neutral,0.3041551326982752,,0.6547064942426188,0.24646,,1.7839469296659047,,1.0152034648329524,,Neutral,,Neutral,,0.18478867675557756,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.3001,2.0195,-20.5824,-4.48203356518943,0.0894131889642919,Benign,0.636,pathogenic,-3.395,available,https://doi.org/10.1101/2022.10.22.513328 +L93H,NP_000537:p.Leu93His,,,,,saturation_mutlist,,,,,,,,0.67541,0.03760995864868163,,0.6199295780941688,,0.6476697890470844,,Neutral,Neutral,,Neutral,0.09611770924204731,,0.4749850699821125,0.56779,,0.41574223521253856,,0.4917661176062693,,Neutral,,Neutral,,0.06481898504375279,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.2676,2.0195,-20.5824,-1.99435145688493,0.0052305032321909,Benign,0.5051,ambiguous,-3.314,available,https://doi.org/10.1101/2022.10.22.513328 +L93I,NP_000537:p.Leu93Ile,,,,,saturation_mutlist,,,,,,,,0.37293,-0.21429343461990358,,0.6027657539851083,,0.48784787699255416,,Neutral,Neutral,,Neutral,0.19255925087550096,,0.32317490098930385,0.42753,,0.32570653992802573,,0.3766182699640129,,Neutral,,Neutral,,0.15021232573723817,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.0264,2.0195,-6.2946,-2.99324817973558,0.0093101687232552,Benign,0.1815,benign,-3.358,available,https://doi.org/10.1101/2022.10.22.513328 +L93K,NP_000537:p.Leu93Lys,,,,,saturation_mutlist,,,,,,,,0.2534,-0.048469192981719963,,0.91367692819386,,0.58353846409693,,Neutral,Neutral,,Neutral,0.11771841229023872,,0.5301282050319476,-0.00511,,0.7241835613419646,,0.3595367806709823,,Neutral,,Neutral,,0.09394579215937138,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.3138,2.0195,-20.5824,-3.74387614296158,0.0977368140255221,Benign,0.6189,pathogenic,-3.435,available,https://doi.org/10.1101/2022.10.22.513328 +L93M,NP_000537:p.Leu93Met,"hg38,17:g.7676092G>T",,,0.369,"COSMIC,saturation_mutlist",,,,,,,,0.05422,0.06982968807220455,0.5388866666666666,0.6585059513996061,0.29655333333333334,0.3563629756998031,Neutral,Neutral,Neutral,Neutral,Neutral,0.03960082167951386,0.3481568346146445,0.31680275702769356,0.05468,0.12789,0.48511903085417396,0.091285,0.26989951542708696,Neutral,Neutral,Neutral,Neutral,0.4059690447148239,0.05399941279373704,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.1226,2.0195,-20.5824,-3.6612659002697,0.0473841459919966,Benign,0.2185,benign,-3.558,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L93N,NP_000537:p.Leu93Asn,,,,,saturation_mutlist,,,,,,,,0.72094,0.1457160127162933,,0.9282688315517889,,0.8246044157758945,,Neutral,Neutral,,Neutral,0.21433865806721622,,0.4114041339159758,0.44793,,0.7640859759437975,,0.6060079879718987,,Neutral,,Neutral,,0.06291333001648913,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.2134,2.0195,-4.9727,-2.55070726551275,0.0071121520024584,Benign,0.6043,pathogenic,-3.289,available,https://doi.org/10.1101/2022.10.22.513328 +L93P,NP_000537:p.Leu93Pro,"hg19,17:g.7579409A>G, hg38,17:g.7676091A>G",,,0.454,"cBioPortal,ClinVar,saturation_mutlist",3359424,Uncertain significance,2,,,,,0.6188,0.3812763357162476,-0.09228999999999994,2.5355026907710037,0.263255,1.5771513453855017,Neutral,Uncertain,Neutral,Neutral,Neutral,0.3109116939480618,0.6953493097717146,1.5935131200070622,0.18261,0.013603333333333337,3.322845059726838,0.09810666666666666,1.752727529863419,Neutral,Uncertain,Neutral,Neutral,0.9321226530284997,0.6949801436938993,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.2155,2.0195,-2.3404,-0.972126353393272,1.1769875923835863e-07,Benign,0.2035,benign,-2.848,available,https://doi.org/10.1101/2022.10.22.513328 +L93Q,NP_000537:p.Leu93Gln,"hg38,17:g.7676091A>T",,,0.469,"COSMIC,saturation_mutlist",,,,,,,,0.37238,0.046137762069702166,,1.041218272053985,,0.7067991360269925,,Neutral,Neutral,,Neutral,0.16475257680469307,,0.48859675594222585,0.07684,,0.8953232245401458,,0.4860816122700729,,Neutral,,Neutral,,0.09566833455093748,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.246,2.0195,-20.5824,-3.68069507398829,0.0012883170554864,Benign,0.3316,benign,-3.26,available,https://doi.org/10.1101/2022.10.22.513328 +L93R,NP_000537:p.Leu93Arg,"hg19,17:g.7579409A>C, hg38,17:g.7676091A>C",,,0.498,"ClinVar,saturation_mutlist",2825997,Uncertain significance,1,,,,,0.39228,-0.050660312175750705,,0.7517936303233915,,0.5720368151616958,,Neutral,Neutral,,Neutral,0.10365738074467945,,0.43137516571043055,-0.15007,,0.34701327329430137,,0.09847163664715068,,Neutral,,Neutral,,0.09959091393305076,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,neutral,,-0.3054,2.0195,-20.5824,-3.67649296587768,0.0549362428711858,Benign,0.4359,ambiguous,-3.362,available,https://doi.org/10.1101/2022.10.22.513328 +L93S,NP_000537:p.Leu93Ser,,,,,saturation_mutlist,,,,,,,,0.90077,-0.11634625792503356,,1.1344158791662424,,1.0175929395831211,,Neutral,Neutral,,Neutral,0.20161553244561956,,0.697320067213455,0.39033,,1.1779414386403741,,0.7841357193201871,,Neutral,,Neutral,,0.24419873951691137,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.1797,2.0195,-5.7096,-1.81498187094926,8.260849118849823e-06,Benign,0.4072,ambiguous,-2.934,available,https://doi.org/10.1101/2022.10.22.513328 +L93T,NP_000537:p.Leu93Thr,,,,,saturation_mutlist,,,,,,,,0.72928,-0.28109142541885374,,1.0147920660084278,,0.8720360330042138,,Neutral,Neutral,,Neutral,0.12229073072891702,,0.6290474685057581,0.47731,,0.960714108952642,,0.719012054476321,,Neutral,,Neutral,,0.28004742071599187,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.1436,2.0195,-3.9727,-1.10512047812244,8.003061773126843e-09,Benign,0.3346,benign,-2.89,available,https://doi.org/10.1101/2022.10.22.513328 +L93V,NP_000537:p.Leu93Val,"hg19,17:g.7579410G>C",,,0.523,"cBioPortal,saturation_mutlist",,,,,,,,0.53862,-0.14056405782699585,0.35351333333333335,0.7870339526889002,0.44606666666666667,0.6628269763444501,Neutral,Neutral,Neutral,Neutral,Neutral,0.13325222613024584,0.123738124637837,0.4172974320411618,0.70396,2.038206666666667,0.4531177664328343,1.3710833333333334,0.5785388832164171,Uncertain,Neutral,Neutral,Neutral,1.434860328076879,0.07833428241332165,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,uncertain,,-0.056,2.0195,-4.9727,-1.6273262742249,0.0003765152340316,Benign,0.1396,benign,-3.157,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L93W,NP_000537:p.Leu93Trp,,,,,saturation_mutlist,,,,,,,,0.25614,0.07416700839996337,,0.26594349731308425,,0.2610417486565421,,Neutral,Neutral,,Neutral,0.11710108838489935,,0.41467837951243736,0.31047,,0.10229053137800574,,0.2063802656890029,,Neutral,,Neutral,,0.10866707965715339,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,neutral,,-0.2578,2.0195,-20.5824,-4.39451215448914,0.6057636158494181,Uncertain,0.6015,pathogenic,-3.794,available,https://doi.org/10.1101/2022.10.22.513328 +L93Y,NP_000537:p.Leu93Tyr,,,,,saturation_mutlist,,,,,,,,0.02788,0.06442487239837646,,0.675596960429739,,0.35173848021486953,,Neutral,Neutral,,Neutral,0.12313904359395665,,0.40423522040837556,-0.06567,,0.3178627986916541,,0.12609639934582706,,Neutral,,Neutral,,0.08844823112819551,68.45,21.577,72.11,11.419,,True,68.45,,neutral,neutral,neutral,,True,72.11,,neutral,neutral,neutral,neutral,,-0.2507,2.0195,-20.5824,-3.53915697937206,0.2666488553267249,Benign,0.6637,pathogenic,-3.396,available,https://doi.org/10.1101/2022.10.22.513328 +S94A,NP_000537:p.Ser94Ala,"hg19,17:g.7579407A>C, hg38,17:g.7676089A>C",,,0.476,"ClinVar,saturation_mutlist",3460308,Likely benign,1,,,,,-0.03838,0.32490495681762693,,0.11434572084938738,,0.03798286042469369,,Neutral,Neutral,,Neutral,0.30314460986816166,,0.21578781789403698,-0.57619,,0.1847915903742138,,-0.1956992048128931,,Neutral,,Neutral,,0.1012461882293673,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.0586,1.3645,-3.372,-1.56212327402617,1.94384983719918e-05,Benign,0.1502,benign,-3.049,available,https://doi.org/10.1101/2022.10.22.513328 +S94C,NP_000537:p.Ser94Cys,,,,,saturation_mutlist,,,,,,,,-0.04175,0.15963658571243286,,0.6982843935869713,,0.32826719679348565,,Neutral,Neutral,,Neutral,0.32588679007087773,,0.2632720042140807,0.38154,,0.5817540803477693,,0.48164704017388466,,Neutral,,Neutral,,0.17910819956383028,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.1249,1.3645,-6.4594,-1.68211249867161,0.0038006281392755,Benign,0.309,benign,-3.411,available,https://doi.org/10.1101/2022.10.22.513328 +S94D,NP_000537:p.Ser94Asp,,,,,saturation_mutlist,,,,,,,,0.21509,0.7846688091754913,,-0.12758508345675873,,0.04375245827162064,,Neutral,Neutral,,Neutral,0.48394536002722144,,0.07844123684108646,3.90412,,1.1118072772439707,,2.5079636386219852,,Uncertain,,Uncertain,,0.20297544777732474,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.1629,1.3645,-4.4594,-4.0170483131042,0.5272674440374404,Uncertain,0.9271,pathogenic,-3.524,available,https://doi.org/10.1101/2022.10.22.513328 +S94E,NP_000537:p.Ser94Glu,,,,,saturation_mutlist,,,,,,,,0.59129,0.7716885662078857,,-0.18821874678400752,,0.20153562660799623,,Neutral,Neutral,,Neutral,0.5940237803019952,,0.13499000674478986,4.18593,,1.272974523433173,,2.7294522617165864,,Uncertain,,Uncertain,,0.3203913205185903,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.2192,1.3645,-20.7472,-3.94498980320792,0.150822334273034,Benign,0.9373,pathogenic,-3.628,available,https://doi.org/10.1101/2022.10.22.513328 +S94F,NP_000537:p.Ser94Phe,,,,,saturation_mutlist,,,,,,,,1.65654,0.5524617338180542,,-0.45659061655054045,,0.5999746917247297,,Neutral,Neutral,,Neutral,0.571212132784279,,0.35508990440248617,15.10047,,-0.22765131664984428,,7.436409341675078,,Uncertain,,Destabilizing,,0.5380289234584574,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.2254,1.3645,-20.7472,-4.57560261069663,0.3222859218220883,Uncertain,0.7408,pathogenic,-3.601,available,https://doi.org/10.1101/2022.10.22.513328 +S94G,NP_000537:p.Ser94Gly,,,,,saturation_mutlist,,,,,,,,0.30809,0.7094296348094941,,0.7425829466725756,,0.5253364733362877,,Neutral,Neutral,,Neutral,0.42336400121125156,,0.11819781073942186,-0.49257,,1.2367861509396862,,0.37210807546984315,,Neutral,,Neutral,,0.17939315196628752,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.0887,1.3645,-7.4593,-3.76010924502571,0.0388820177233675,Benign,0.3203,benign,-3.296,available,https://doi.org/10.1101/2022.10.22.513328 +S94H,NP_000537:p.Ser94His,,,,,saturation_mutlist,,,,,,,,2.02368,0.6276265382766724,,-0.448772122040072,,0.7874539389799641,,Uncertain,Neutral,,Neutral,0.48686224127959543,,0.1657500551678956,13.63741,,0.05397074445032642,,6.845690372225163,,Uncertain,,Destabilizing,,0.2783295634100836,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.2266,1.3645,-20.7472,-3.81593281544085,0.149651043026511,Benign,0.8654,pathogenic,-3.56,available,https://doi.org/10.1101/2022.10.22.513328 +S94I,NP_000537:p.Ser94Ile,,,,,saturation_mutlist,,,,,,,,0.1727,0.523535647392273,,-0.29047418150415744,,-0.05888709075207872,,Neutral,Neutral,,Neutral,0.5589104950937678,,0.47446824568031437,3.88342,,0.04972909074569931,,1.9665745453728496,,Uncertain,,Neutral,,0.33331932826368227,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.2285,1.3645,-20.7472,-3.56475722317723,0.2556552566718552,Benign,0.7723,pathogenic,-3.59,available,https://doi.org/10.1101/2022.10.22.513328 +S94K,NP_000537:p.Ser94Lys,,,,,saturation_mutlist,,,,,,,,0.55647,0.6803962707519531,,-0.10101695178969268,,0.22772652410515368,,Neutral,Neutral,,Neutral,0.5374026526548642,,0.15596087938361575,3.93121,,0.7578151711234616,,2.344512585561731,,Uncertain,,Uncertain,,0.20647796234024404,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.2359,1.3645,-20.7472,-4.11204179485188,0.1795284700789453,Benign,0.9852,pathogenic,-3.752,available,https://doi.org/10.1101/2022.10.22.513328 +S94L,NP_000537:p.Ser94Leu,"hg19,17:g.7579406G>A, hg38,17:g.7676088G>A",,,0.553,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1796426,Likely benign,1,,,,,0.09536,0.6729784846305847,0.12846000000000002,-0.5710922664269714,0.11191000000000001,-0.2378661332134857,Neutral,Neutral,Neutral,Neutral,Neutral,0.5283484831061098,0.4800515766040145,0.2981616916353753,3.2932,2.2426299999999997,-0.41865166782295926,2.767915,1.4372741660885204,Uncertain,Uncertain,Uncertain,Neutral,2.2655156057286385,0.5152432888429411,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.2248,1.3645,-20.7472,-3.70352067652373,0.0730685594066265,Benign,0.418,ambiguous,-3.407,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S94M,NP_000537:p.Ser94Met,,,,,saturation_mutlist,,,,,,,,-0.11732,0.45760239362716676,,-0.19310370670466534,,-0.15521185335233267,,Neutral,Neutral,,Neutral,0.41268871568427457,,0.30181190192092666,1.34487,,-0.1403152188406294,,0.6022773905796853,,Neutral,,Neutral,,0.3947356732844214,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.1958,1.3645,-20.7472,-3.59355822842575,0.1845266982563653,Benign,0.6504,pathogenic,-3.602,available,https://doi.org/10.1101/2022.10.22.513328 +S94N,NP_000537:p.Ser94Asn,,,,,saturation_mutlist,,,,,,,,0.39479,0.5684212553501129,,-0.07812013644476326,,0.15833493177761837,,Neutral,Neutral,,Neutral,0.38539499936488986,,0.06048198085869732,3.10553,,0.3177010558781666,,1.7116155279390832,,Uncertain,,Neutral,,0.2637934752672336,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.1696,1.3645,-20.7472,-3.89067554066391,0.2340316492730176,Benign,0.7584,pathogenic,-3.505,available,https://doi.org/10.1101/2022.10.22.513328 +S94P,NP_000537:p.Ser94Pro,"hg38,17:g.7676089A>G",,,0.528,"COSMIC,saturation_mutlist",,,,,,,,1.19311,1.3559911441802979,1.3052133333333333,1.281548094253962,1.2491616666666667,1.2373290471269809,Neutral,Neutral,Uncertain,Neutral,Neutral,0.5798138705824591,1.615076224627047,0.577585279545958,2.21553,4.51417,3.7774501805520004,3.36485,2.9964900902760006,Uncertain,Uncertain,Destabilizing,Uncertain,0.8019969142500903,1.2162036730249237,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.3008,1.3645,-20.7472,-3.4641723347253,0.0519329135204096,Benign,0.3757,ambiguous,-3.272,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S94Q,NP_000537:p.Ser94Gln,,,,,saturation_mutlist,,,,,,,,0.50431,0.5648135161399841,,0.05069881810681929,,0.2775044090534097,,Neutral,Neutral,,Neutral,0.44305348333520045,,0.1844136474312409,3.69281,,0.6416384850495299,,2.167224242524765,,Uncertain,,Uncertain,,0.2609637973077994,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.1892,1.3645,-20.7472,-3.81098517197492,0.2129047108591134,Benign,0.898,pathogenic,-3.428,available,https://doi.org/10.1101/2022.10.22.513328 +S94R,NP_000537:p.Ser94Arg,,,,,saturation_mutlist,,,,,,,,0.66188,0.6001648211479187,,-0.29598908376448696,,0.18294545811775653,,Neutral,Neutral,,Neutral,0.4648311427439996,,0.2286426922353489,6.08398,,0.022230966146260505,,3.0531054830731303,,Uncertain,,Destabilizing,,0.25550750791368726,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.2412,1.3645,-20.7472,-5.006526004605,0.367506146511582,Uncertain,0.9766,pathogenic,-3.711,available,https://doi.org/10.1101/2022.10.22.513328 +S94T,NP_000537:p.Ser94Thr,"hg19,17:g.7579407A>T, hg38,17:g.7676089A>T",,,0.533,"COSMIC,ClinVar,saturation_mutlist",3634434,Uncertain significance,1,,,,,0.09313,0.15978989839553834,0.21995666666666666,-0.02696067475918883,0.15654333333333334,0.03308466262040559,Neutral,Neutral,Neutral,Neutral,Neutral,0.2204391493033854,0.04187639695845645,0.21461906296923636,1.43977,0.028003333333333307,0.3703497425509655,0.7338866666666667,0.9050598712754827,Neutral,Neutral,Neutral,Neutral,0.625831467480574,0.0803889706864429,48.942,33.444,4.995,5.267,,True,48.942,,neutral,,,,True,4.995,,neutral,,,uncertain,,-0.0474,1.3645,-3.0,-1.25737220118974,1.7053555002961567e-08,Benign,0.1639,benign,-2.99,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S94V,NP_000537:p.Ser94Val,,,,,saturation_mutlist,,,,,,,,0.07338,0.42498972415924074,,-0.17646348910531426,,-0.05154174455265713,,Neutral,Neutral,,Neutral,0.46424451402658967,,0.4449302589342846,2.4011,,-0.028228027071412837,,1.1864359864642935,,Uncertain,,Neutral,,0.20279323580465533,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.2028,1.3645,-20.7472,-2.95005419863415,0.3308457305355405,Uncertain,0.6211,pathogenic,-3.512,available,https://doi.org/10.1101/2022.10.22.513328 +S94W,NP_000537:p.Ser94Trp,,,,,saturation_mutlist,,,,,,,,2.7157,0.40304495096206666,,-0.8598952051304288,,0.9279023974347855,,Uncertain,Neutral,,Neutral,0.6050079021943674,,0.32844846124742894,19.98697,,-0.47786562591324033,,9.75455218704338,,Uncertain,,Destabilizing,,0.40254216535704546,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.2351,1.3645,-20.7472,-4.93180911905865,0.790329777694893,Pathogenic,0.8429,pathogenic,-3.93,available,https://doi.org/10.1101/2022.10.22.513328 +S94Y,NP_000537:p.Ser94Tyr,,,,,saturation_mutlist,,,,,,,,2.27525,0.6205442142486572,,-0.4518172274372385,,0.9117163862813809,,Uncertain,Neutral,,Neutral,0.641545592197207,,0.32774015709080145,19.25757,,0.03440341555358909,,9.645986707776796,,Uncertain,,Destabilizing,,0.4972453275118185,48.942,33.444,4.995,5.267,,True,48.942,,uncertain,,,,True,4.995,,uncertain,,,uncertain,,-0.2302,1.3645,-20.7472,-4.93180911905865,0.5990972720667167,Uncertain,0.7639,pathogenic,-3.758,available,https://doi.org/10.1101/2022.10.22.513328 +S95A,NP_000537:p.Ser95Ala,,,,,saturation_mutlist,,,,,,,,-0.00677,0.07255279064178467,,-0.2025649049766963,,-0.10466745248834815,,Neutral,Neutral,,Neutral,0.22107150635802153,,0.18385582080686794,-0.11657,,-0.050567336618717006,,-0.0835686683093585,,Neutral,,Neutral,,0.04908811543066717,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.0608,1.4458,-5.263,-1.71627596163644,0.0001944473850016,Benign,0.1129,benign,-3.242,available,https://doi.org/10.1101/2022.10.22.513328 +S95C,NP_000537:p.Ser95Cys,,,,,saturation_mutlist,,,,,,,,0.00439,-0.005118825435638412,,0.38803619999076444,,0.19621309999538222,,Neutral,Neutral,,Neutral,0.25025573854115596,,0.16889502593800174,0.17889,,0.36226216335494915,,0.2705760816774746,,Neutral,,Neutral,,0.16222895769720572,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.1232,1.4458,-7.5849,-1.86625679685849,0.0012638791501257,Benign,0.1946,benign,-3.33,available,https://doi.org/10.1101/2022.10.22.513328 +S95D,NP_000537:p.Ser95Asp,,,,,saturation_mutlist,,,,,,,,0.68663,0.898197294473648,,0.2990398873020808,,0.4928349436510404,,Neutral,Neutral,,Neutral,0.6901591406428046,,0.5820987238820301,-0.29689,,-0.5109074159390251,,-0.40389870796951255,,Neutral,,Neutral,,0.06939271581070218,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.2443,1.4458,-21.8727,-4.48921668319848,0.3742817151648986,Uncertain,0.9294,pathogenic,-3.657,available,https://doi.org/10.1101/2022.10.22.513328 +S95E,NP_000537:p.Ser95Glu,,,,,saturation_mutlist,,,,,,,,0.74846,0.7628828620910645,,0.28942312774834295,,0.5189415638741715,,Neutral,Neutral,,Neutral,0.5944391621686803,,0.785135368660624,-0.26264,,-0.38573305489101406,,-0.324186527445507,,Neutral,,Neutral,,0.12821940693300266,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.2175,1.4458,-21.8727,-3.55089874691538,0.5546601439377166,Uncertain,0.9511,pathogenic,-3.854,available,https://doi.org/10.1101/2022.10.22.513328 +S95F,NP_000537:p.Ser95Phe,"hg19,17:g.7579403G>A, hg19,17:g.7676085G>A, hg38,17:g.7676085G>A",,,0.751,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1796813,Uncertain significance,2,,,,,1.74619,0.5744238722324372,0.5620200000000001,-0.26329131994361743,1.154105,0.7414493400281912,Neutral,Neutral,Neutral,Neutral,Neutral,0.43893572607273407,0.6612354257499115,0.6680078707321008,-0.22084,-0.9526066666666667,-0.4532279622948094,-0.5867233333333334,-0.3370339811474047,Neutral,Neutral,Neutral,Neutral,0.5836658137629405,0.13556231582384268,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.1558,1.4458,-8.5848,-4.7110723281636,0.20821639503736,Benign,0.5749,pathogenic,-3.619,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S95G,NP_000537:p.Ser95Gly,,,,,saturation_mutlist,,,,,,,,0.02254,0.4489476323127747,,0.8466029914886483,,0.43457149574432413,,Neutral,Neutral,,Neutral,0.30573402879395734,,0.1011834052248909,-0.38514,,-0.05795272950643653,,-0.22154636475321826,,Neutral,,Neutral,,0.2683037092543932,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.0869,1.4458,-8.5848,-3.67023605996198,0.043884283362602,Benign,0.2855,benign,-3.407,available,https://doi.org/10.1101/2022.10.22.513328 +S95H,NP_000537:p.Ser95His,,,,,saturation_mutlist,,,,,,,,1.89732,0.5975822877883911,,-0.13972947378956055,,0.8787952631052197,,Neutral,Neutral,,Neutral,0.5228397913503308,,0.6180856345978112,0.19768,,-0.6480853540031589,,-0.22520267700157948,,Neutral,,Neutral,,0.07155919201103751,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.2249,1.4458,-21.8727,-4.4650546267409,0.8231434215473808,Pathogenic,0.8547,pathogenic,-3.706,available,https://doi.org/10.1101/2022.10.22.513328 +S95I,NP_000537:p.Ser95Ile,,,,,saturation_mutlist,,,,,,,,0.74178,0.37254623174667356,,-0.3658020670088864,,0.1879889664955568,,Neutral,Neutral,,Neutral,0.4262150950150311,,0.19355625056768322,0.65175,,0.07719092844650138,,0.3644704642232507,,Neutral,,Neutral,,0.3912435143585432,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.2268,1.4458,-21.8727,-4.83432270971047,0.5077313907029326,Uncertain,0.7491,pathogenic,-3.694,available,https://doi.org/10.1101/2022.10.22.513328 +S95K,NP_000537:p.Ser95Lys,,,,,saturation_mutlist,,,,,,,,0.66283,0.59478835105896,,0.5957341378515094,,0.6292820689257548,,Neutral,Neutral,,Neutral,0.5739187675185446,,0.9506190562524942,-0.22288,,-0.4614045193037466,,-0.3421422596518733,,Neutral,,Neutral,,0.2168086636702276,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.2342,1.4458,-21.8727,-5.85970868158159,0.7232675333413295,Pathogenic,0.9885,pathogenic,-3.788,available,https://doi.org/10.1101/2022.10.22.513328 +S95L,NP_000537:p.Ser95Leu,,,,,saturation_mutlist,,,,,,,,0.47514,0.5880039453506469,,-0.6978443870269699,,-0.11135219351348496,,Neutral,Neutral,,Neutral,0.5249849182240979,,0.37543437193711593,-0.18625,,-0.7292991829855312,,-0.4577745914927656,,Neutral,,Neutral,,0.08342766773485757,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.223,1.4458,-21.8727,-3.3327467737705,0.2033369136338462,Benign,0.4096,ambiguous,-3.546,available,https://doi.org/10.1101/2022.10.22.513328 +S95M,NP_000537:p.Ser95Met,,,,,saturation_mutlist,,,,,,,,-0.01039,0.37758429288864137,,-0.30525637223252783,,-0.15782318611626392,,Neutral,Neutral,,Neutral,0.3467328087295693,,0.37842491134954176,-0.07999,,-0.41060059288620593,,-0.24529529644310297,,Neutral,,Neutral,,0.10488947858370284,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.1941,1.4458,-21.8727,-4.78839393439237,0.4440665153345293,Uncertain,0.6351,pathogenic,-3.834,available,https://doi.org/10.1101/2022.10.22.513328 +S95N,NP_000537:p.Ser95Asn,,,,,saturation_mutlist,,,,,,,,0.65303,0.6625834393501282,,-0.1771847411669825,,0.23792262941650877,,Neutral,Neutral,,Neutral,0.5840039561499423,,0.30039431844146014,0.02161,,-0.6897464296445525,,-0.3340682148222762,,Neutral,,Neutral,,0.22442785461157205,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.1679,1.4458,-21.8727,-3.99569220537374,0.2333324876406342,Benign,0.753,pathogenic,-3.534,available,https://doi.org/10.1101/2022.10.22.513328 +S95P,NP_000537:p.Ser95Pro,,,,,saturation_mutlist,,,,,,,,1.76535,0.9349635219573975,,3.2059520076786185,,2.485651003839309,,Uncertain,Neutral,,Uncertain,0.8921749079751439,,1.4483019077208799,0.7473,,3.367798950291082,,2.057549475145541,,Uncertain,,Uncertain,,2.3434251855154122,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.1919,1.4458,-0.8845,-1.29624277371681,0.0002128928392532,Benign,0.3471,ambiguous,-3.057,available,https://doi.org/10.1101/2022.10.22.513328 +S95Q,NP_000537:p.Ser95Gln,,,,,saturation_mutlist,,,,,,,,0.67013,0.4709046936035156,,0.12426594123824276,,0.3971979706191214,,Neutral,Neutral,,Neutral,0.4604822188111237,,0.4631423868086816,-0.20679,,-0.23492210000736166,,-0.22085605000368083,,Neutral,,Neutral,,0.15327060964282457,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.1875,1.4458,-21.8727,-3.93035616761955,0.2174235054896063,Benign,0.9124,pathogenic,-3.514,available,https://doi.org/10.1101/2022.10.22.513328 +S95R,NP_000537:p.Ser95Arg,,,,,saturation_mutlist,,,,,,,,0.81588,0.5225171971321106,,0.08065839318926278,,0.44826919659463144,,Neutral,Neutral,,Neutral,0.5154957297179018,,0.6249669466508624,-0.41873,,-0.5905217008798253,,-0.5046258504399126,,Neutral,,Neutral,,0.18505543001511715,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.2395,1.4458,-21.8727,-5.85970868158159,0.6022650920964228,Uncertain,0.9791,pathogenic,-3.708,available,https://doi.org/10.1101/2022.10.22.513328 +S95T,NP_000537:p.Ser95Thr,"hg19,17:g.7579404A>T, hg19,17:g.7676086A>T, hg38,17:g.7676086A>T",,,0.584,"cBioPortal,ClinVar,saturation_mutlist",4189261,Likely benign,1,,,,,0.4971,0.0323952031135559,0.27982,0.01655386850294834,0.38846,0.2568269342514742,Neutral,Neutral,Neutral,Neutral,Neutral,0.20389509492917288,0.8826091125747569,0.1439337748095538,0.39463,0.2564633333333333,0.2222486426020672,0.32554666666666665,0.3084393213010336,Neutral,Neutral,Neutral,Neutral,0.508979285585922,0.274328133813443,49.262,31.551,100.2,8.793,,True,49.262,,neutral,,,,True,100.2,,neutral,,,uncertain,,-0.0468,1.4458,-4.337,-2.06507932473082,0.0032512674269952,Benign,0.208,benign,-3.226,available,https://doi.org/10.1101/2022.10.22.513328 +S95V,NP_000537:p.Ser95Val,,,,,saturation_mutlist,,,,,,,,0.703,0.22335925817489624,,-0.4471352834150655,,0.12793235829246724,,Neutral,Neutral,,Neutral,0.44764936245617204,,0.1550825851035659,0.56925,,0.15342125258369513,,0.36133562629184757,,Neutral,,Neutral,,0.22530111398792077,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.201,1.4458,-21.8727,-4.13720708242182,0.1205819576314009,Benign,0.554,ambiguous,-3.528,available,https://doi.org/10.1101/2022.10.22.513328 +S95W,NP_000537:p.Ser95Trp,,,,,saturation_mutlist,,,,,,,,1.94383,0.5675844264030456,,-0.36612220173552307,,0.7888538991322385,,Neutral,Neutral,,Neutral,0.5236650221993955,,1.2371901156127132,0.01554,,-0.6958441667154807,,-0.34015208335774033,,Neutral,,Neutral,,0.0936780201092973,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.2333,1.4458,-21.8727,-5.04761796011238,0.7898209021894601,Pathogenic,0.794,pathogenic,-3.957,available,https://doi.org/10.1101/2022.10.22.513328 +S95Y,NP_000537:p.Ser95Tyr,,,,,saturation_mutlist,,,,,,,,1.63616,0.7128761720657348,,-0.036994542028949716,,0.7995827289855252,,Neutral,Neutral,,Neutral,0.5577811592613526,,0.7585630208409849,-0.15038,,-0.34102021111455766,,-0.24570010555727884,,Neutral,,Neutral,,0.11098142164696552,49.262,31.551,100.2,8.793,,True,49.262,,uncertain,,,,True,100.2,,uncertain,,,uncertain,,-0.2285,1.4458,-21.8727,-5.04761796011238,0.5262064675961159,Uncertain,0.6561,pathogenic,-3.802,available,https://doi.org/10.1101/2022.10.22.513328 +S96A,NP_000537:p.Ser96Ala,,,,,saturation_mutlist,,,,,,,,-0.18996,0.16013771295547485,,-0.15894251492814482,,-0.17445125746407242,,Neutral,Neutral,,Neutral,0.08041093422228414,,0.26748251203885537,-0.0426,,0.2117617963901864,,0.08458089819509321,,Neutral,,Neutral,,0.28298475146986896,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,0.0071,1.939,-0.8554,-1.35742066572025,3.056026280851333e-08,Benign,0.0705,benign,-2.907,available,https://doi.org/10.1101/2022.10.22.513328 +S96C,NP_000537:p.Ser96Cys,"hg38,17:g.7676082G>C",,,0.497,"COSMIC,saturation_mutlist",,,,,,,,-0.08053,-0.08051586866378785,0.37245,0.5150514441347465,0.14596,0.21726072206737324,Neutral,Neutral,Neutral,Neutral,Neutral,0.12586433334104113,0.18159360634853494,0.22508827032971201,0.17079,0.5964833333333334,0.6411386170957271,0.3836366666666667,0.40596430854786353,Neutral,Neutral,Neutral,Neutral,0.25812666946460394,0.18511670073115558,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.0779,1.939,-7.6036,-0.34128869387561,0.0001236835924297,Benign,0.0735,benign,-3.399,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S96D,NP_000537:p.Ser96Asp,,,,,saturation_mutlist,,,,,,,,-0.36798,0.20823806524276733,,0.08804918088787783,,-0.13996540955606107,,Neutral,Neutral,,Neutral,0.18308193597913913,,0.24065381989553347,-0.5227,,0.06705438797264744,,-0.2278228060136763,,Neutral,,Neutral,,0.12267969840593503,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1231,1.939,-7.0186,-3.68180297665221,0.0021579427427872,Benign,0.7525,pathogenic,-3.256,available,https://doi.org/10.1101/2022.10.22.513328 +S96E,NP_000537:p.Ser96Glu,,,,,saturation_mutlist,,,,,,,,-0.42391,0.07197998523712157,,-0.155068059004404,,-0.289489029502202,,Neutral,Neutral,,Neutral,0.15621233785172195,,0.19709909084349242,-0.20595,,0.21403863571388557,,0.004044317856942786,,Neutral,,Neutral,,0.2977168119913678,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1722,1.939,-21.8913,-4.09869736106783,0.0111628043353425,Benign,0.7954,pathogenic,-3.285,available,https://doi.org/10.1101/2022.10.22.513328 +S96F,NP_000537:p.Ser96Phe,"hg19,17:g.7579400G>A, hg38,17:g.7676082G>A",,,0.401,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.88508,0.2664785635471344,-0.36247333333333337,-0.549436875396517,-0.6237766666666666,-0.7172584376982585,Neutral,Neutral,Neutral,Neutral,Neutral,0.3133037343570384,0.10801241914191578,0.306557365256363,0.09224,-0.32018,-0.4480239396041246,-0.11397000000000002,-0.17789196980206232,Neutral,Neutral,Neutral,Neutral,0.9689206333854181,0.32779574115011884,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.0875,1.939,-4.0801,-1.07794336160378,1.9314864756330438e-07,Benign,0.1005,benign,-2.986,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S96G,NP_000537:p.Ser96Gly,,,,,saturation_mutlist,,,,,,,,0.00037,0.4040806317329407,,0.5798330806617483,,0.29010154033087415,,Neutral,Neutral,,Neutral,0.16362362797684143,,0.17050527535507679,-0.20418,,0.7029125588030869,,0.24936627940154343,,Neutral,,Neutral,,0.13917048346874744,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1095,1.939,-21.8913,-3.51019663724948,0.0892098936224562,Benign,0.185,benign,-3.356,available,https://doi.org/10.1101/2022.10.22.513328 +S96H,NP_000537:p.Ser96His,,,,,saturation_mutlist,,,,,,,,-0.05072,0.2663397645950317,,-0.3389430543866217,,-0.19483152719331084,,Neutral,Neutral,,Neutral,0.19015399468340696,,0.20880960474883142,0.54187,,-0.44727766797741736,,0.0472961660112913,,Neutral,,Neutral,,0.17059587018818592,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1796,1.939,-21.8913,-3.26675595591615,0.0010630626498775,Benign,0.5035,ambiguous,-3.27,available,https://doi.org/10.1101/2022.10.22.513328 +S96I,NP_000537:p.Ser96Ile,,,,,saturation_mutlist,,,,,,,,-0.04887,0.27383439779281615,,-0.5078283534246982,,-0.2783491767123491,,Neutral,Neutral,,Neutral,0.2297764481737439,,0.14605877046771967,0.7524,,0.1541193455257145,,0.4532596727628572,,Neutral,,Neutral,,0.4688322949485361,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1086,1.939,-7.6036,-1.74151289994249,3.371691239113086e-06,Benign,0.2336,benign,-3.109,available,https://doi.org/10.1101/2022.10.22.513328 +S96K,NP_000537:p.Ser96Lys,,,,,saturation_mutlist,,,,,,,,-0.70041,0.4228831195831299,,-0.2435150494082848,,-0.4719625247041424,,Neutral,Neutral,,Neutral,0.24684505226336023,,0.24604116135831083,0.14833,,0.09546181469331246,,0.12189590734665623,,Neutral,,Neutral,,0.1645327910811023,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1889,1.939,-21.8913,-4.75464975243647,0.0109219295614495,Benign,0.9203,pathogenic,-3.409,available,https://doi.org/10.1101/2022.10.22.513328 +S96L,NP_000537:p.Ser96Leu,,,,,saturation_mutlist,,,,,,,,-0.70934,0.3588208019733429,,-0.803810284185591,,-0.7565751420927955,,Neutral,Neutral,,Neutral,0.16703039145649848,,0.2813559825747677,0.05415,,-0.4851860838358651,,-0.21551804191793256,,Neutral,,Neutral,,0.19545451179555615,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1099,1.939,-8.6035,-2.22608306694327,0.0001893663082115,Benign,0.1676,benign,-3.084,available,https://doi.org/10.1101/2022.10.22.513328 +S96M,NP_000537:p.Ser96Met,,,,,saturation_mutlist,,,,,,,,-0.94735,0.3062430238723755,,-0.36117615532123376,,-0.6542630776606169,,Neutral,Neutral,,Neutral,0.14805713202461773,,0.31562889702491814,-0.05082,,-0.2387367406700223,,-0.14477837033501115,,Neutral,,Neutral,,0.14499631552171724,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1488,1.939,-21.8913,-2.20697817288065,0.0025671382305458,Benign,0.2261,benign,-3.435,available,https://doi.org/10.1101/2022.10.22.513328 +S96N,NP_000537:p.Ser96Asn,,,,,saturation_mutlist,,,,,,,,-0.21775,0.28667559862136843,,-0.020740327873950984,,-0.11924516393697548,,Neutral,Neutral,,Neutral,0.17223761255343206,,0.2295481394581245,0.13865,,-0.18829945503900639,,-0.024824727519503195,,Neutral,,Neutral,,0.12609940658188817,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1226,1.939,-21.8913,-3.65748934132842,0.0005777655663437,Benign,0.3709,ambiguous,-3.28,available,https://doi.org/10.1101/2022.10.22.513328 +S96P,NP_000537:p.Ser96Pro,"hg38,17:g.7676083A>G",,,0.522,"COSMIC,saturation_mutlist",,,,,,,,1.65282,0.4844123363494873,1.1464866666666667,3.0733325031793997,1.3996533333333332,2.3630762515896997,Neutral,Uncertain,Neutral,Neutral,Uncertain,0.6262962536297962,2.611520834307515,2.189840858326982,2.86931,8.030386666666667,4.641061570943368,5.449848333333334,3.755185785471684,Uncertain,Uncertain,Destabilizing,Destabilizing,1.81904217098511,0.5499921954448753,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1859,1.939,-8.6035,-3.03071754527268,0.000172308026415,Benign,0.3417,ambiguous,-3.026,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S96Q,NP_000537:p.Ser96Gln,,,,,saturation_mutlist,,,,,,,,-0.31767,0.2639864683151245,,-0.0374458576836632,,-0.1775579288418316,,Neutral,Neutral,,Neutral,0.11615044244732706,,0.24249657224498894,0.06948,,0.16984038548682487,,0.11966019274341244,,Neutral,,Neutral,,0.23883307900364953,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.0744,1.939,-8.6035,-3.32547661459157,0.0024126576651134,Benign,0.6892,pathogenic,-3.173,available,https://doi.org/10.1101/2022.10.22.513328 +S96R,NP_000537:p.Ser96Arg,,,,,saturation_mutlist,,,,,,,,-0.50515,0.44488219380378724,,-0.49810322877922286,,-0.5016266143896114,,Neutral,Neutral,,Neutral,0.23724021109059767,,0.33262295480497,0.23055,,-0.14930944507262195,,0.04062027746368903,,Neutral,,Neutral,,0.1554197803720483,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1942,1.939,-21.8913,-4.9800209563858,0.0176212877479234,Benign,0.8655,pathogenic,-3.421,available,https://doi.org/10.1101/2022.10.22.513328 +S96T,NP_000537:p.Ser96Thr,,,,,saturation_mutlist,,,,,,,,0.26135,0.1049329876899719,,-0.0348037999624336,,0.11327310001878321,,Neutral,Neutral,,Neutral,0.1449085799357969,,0.1100467975299133,0.86312,,0.4226769998701158,,0.6428984999350579,,Neutral,,Neutral,,0.3488356222966769,47.287,17.968,57.865,21.25,,True,47.287,,neutral,,,,True,57.865,,neutral,,,uncertain,,0.0072,1.939,-2.6494,-0.700155032396655,1.1320891300419807e-10,Benign,0.0875,benign,-2.854,available,https://doi.org/10.1101/2022.10.22.513328 +S96V,NP_000537:p.Ser96Val,,,,,saturation_mutlist,,,,,,,,0.23368,0.24226658344268798,,-0.38800774073534045,,-0.07716387036767022,,Neutral,Neutral,,Neutral,0.24349697244961155,,0.1782774836798414,0.9952,,0.17827956971361714,,0.5867397848568086,,Neutral,,Neutral,,0.4338595204737905,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.0685,1.939,-4.7963,-1.76296523696745,2.1694227449796813e-07,Benign,0.1595,benign,-2.954,available,https://doi.org/10.1101/2022.10.22.513328 +S96W,NP_000537:p.Ser96Trp,,,,,saturation_mutlist,,,,,,,,-0.7845,0.2042539095878601,,-0.9129629753380212,,-0.8487314876690106,,Neutral,Neutral,,Neutral,0.31838313094678883,,0.3606011064888883,0.35709,,-0.7375105876460966,,-0.19021029382304827,,Neutral,,Neutral,,0.34671605546712975,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1881,1.939,-21.8913,-4.01761161957871,0.1998227197069803,Benign,0.2772,benign,-3.693,available,https://doi.org/10.1101/2022.10.22.513328 +S96Y,NP_000537:p.Ser96Tyr,"hg19,17:g.7579400G>T, hg38,17:g.7676082G>T",,,0.565,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.69138,0.31918342590332033,-0.52687,-0.45797993788125635,-0.6091249999999999,-0.5746799689406281,Neutral,Neutral,Neutral,Neutral,Neutral,0.3183011103499554,0.28885311469095615,0.280602246431059,0.27126,-0.27142666666666665,-0.36307948643868887,-8.333333333332416e-05,-0.045909743219344434,Neutral,Neutral,Neutral,Neutral,1.0881425261528115,0.288753722859135,47.287,17.968,57.865,21.25,,True,47.287,,uncertain,,,,True,57.865,,uncertain,,,uncertain,,-0.1832,1.939,-21.8913,-4.01761161957871,0.0022393541400475,Benign,0.176,benign,-3.524,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V97A,NP_000537:p.Val97Ala,"hg19,17:g.7579397A>G, hg38,17:g.7676079A>G",,,0.854,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1797574,Uncertain significance,1,,,,,0.99184,0.8581655168533325,1.4624733333333333,1.832743038882157,1.2271566666666667,1.4122915194410786,Neutral,Neutral,Neutral,Neutral,Neutral,0.3027655391528127,0.3647738687948405,0.24974740477993523,-0.29745,0.23820666666666668,0.8152643809035595,-0.029621666666666657,0.25890719045177973,Neutral,Neutral,Neutral,Neutral,0.5142650865933724,0.4635454153658855,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.252,1.0688,-22.1111,-5.36511122484401,0.5487273833264157,Uncertain,0.9394,pathogenic,-3.551,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V97C,NP_000537:p.Val97Cys,,,,,saturation_mutlist,,,,,,,,0.55709,0.44640483379364015,,1.8422964485461664,,1.1996932242730831,,Neutral,Neutral,,Neutral,0.24256323527573084,,0.1444360530655617,-0.26634,,1.2123213764578542,,0.4729906882289271,,Neutral,,Neutral,,0.452183961942525,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.2799,1.0688,-22.1111,-5.17028542499567,0.7643564927010076,Pathogenic,0.9708,pathogenic,-3.83,available,https://doi.org/10.1101/2022.10.22.513328 +V97D,NP_000537:p.Val97Asp,"hg19,17:g.7579397A>T, hg19,17:g.7676079A>T, hg38,17:g.7676079A>T",,,0.937,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182924,Uncertain significance,2,,,,,1.07165,1.333064260482788,1.6597533333333334,2.3752582457373745,1.3657016666666668,1.7234541228686873,Neutral,Uncertain,Uncertain,Neutral,Neutral,0.44163004773244524,0.7650145115108746,0.952892340867957,0.66576,0.4689366666666667,1.0484412617183085,0.5673483333333333,0.8571006308591542,Neutral,Neutral,Neutral,Neutral,0.7311408353768483,0.988917907608261,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.4186,1.0688,-22.1111,-5.76966537956288,0.8367362934207128,Pathogenic,0.9926,pathogenic,-3.869,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V97E,NP_000537:p.Val97Glu,,,,,saturation_mutlist,,,,,,,,0.62508,1.1633733487129212,,2.209925244234105,,1.4175026221170526,,Uncertain,Uncertain,,Neutral,0.3831986180507844,,0.993199366287492,0.54966,,0.9154981995177159,,0.7325790997588579,,Neutral,,Neutral,,0.9065835353355107,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.3759,1.0688,-22.1111,-5.87735687108478,0.7959459747562792,Pathogenic,0.9841,pathogenic,-3.796,available,https://doi.org/10.1101/2022.10.22.513328 +V97F,NP_000537:p.Val97Phe,"hg19,17:g.7579398C>A, hg38,17:g.7676080C>A",,,0.789,"cBioPortal,ClinVar,saturation_mutlist",458532,Conflicting classifications of pathogenicity,1,,,,,0.80064,0.7746292757987976,0.8103166666666667,1.0852642567783437,0.8054783333333333,0.9429521283891719,Neutral,Neutral,Neutral,Neutral,Neutral,0.3320990887116705,0.7184727670243011,1.1935229098389295,0.50202,0.24195,0.0711407838128177,0.371985,0.2865803919064089,Neutral,Neutral,Neutral,Neutral,0.4098032813436222,0.11049700676571766,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.2532,1.0688,-7.2384,-4.01003087254825,0.1053264402537229,Benign,0.7555,pathogenic,-3.327,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V97G,NP_000537:p.Val97Gly,,,,,saturation_mutlist,,,,,,,,1.81299,1.3344033336639405,,3.1036953394151987,,2.4583426697075996,,Uncertain,Uncertain,,Uncertain,0.4010168078288907,,0.733253680377987,0.08787,,1.3618655375968363,,0.7248677687984182,,Neutral,,Neutral,,0.8446365943072389,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.3778,1.0688,-22.1111,-6.7913130174839,0.591603801522253,Uncertain,0.9574,pathogenic,-3.794,available,https://doi.org/10.1101/2022.10.22.513328 +V97H,NP_000537:p.Val97His,,,,,saturation_mutlist,,,,,,,,1.27957,0.9748483610153198,,1.6175292448985576,,1.4485496224492789,,Neutral,Neutral,,Neutral,0.40346502635704556,,1.0553106448619403,1.02022,,0.29083756218935203,,0.6555287810946759,,Neutral,,Neutral,,0.48198859220302726,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.3486,1.0688,-7.8233,-5.66962079249705,0.7114590992447591,Pathogenic,0.99,pathogenic,-3.742,available,https://doi.org/10.1101/2022.10.22.513328 +V97I,NP_000537:p.Val97Ile,"hg19,17:g.7579398C>T, hg38,17:g.7676080C>T",,0.0,0.593,"COSMIC,ClinVar,saturation_mutlist",1026336,Uncertain significance,2,,,,,-0.51574,0.06843060493469239,-0.04183666666666667,0.2742594842319905,-0.2787883333333333,-0.12074025788400475,Neutral,Neutral,Neutral,Neutral,Neutral,0.17393920614786,0.2916243549880946,0.3380747307842618,-0.05638,0.2992066666666667,0.2287762503242067,0.12141333333333335,0.08619812516210335,Neutral,Neutral,Neutral,Neutral,0.1663059594709569,0.22123014857388984,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.078,1.0688,-0.6585,-0.624748642106392,0.0004660953253299,Benign,0.1238,benign,-3.056,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V97K,NP_000537:p.Val97Lys,,,,,saturation_mutlist,,,,,,,,0.3586,0.9532101798057556,,2.313955372438167,,1.3362776862190835,,Uncertain,Neutral,,Neutral,0.40490111338643187,,1.3897598891869267,-0.17486,,0.8804822277150933,,0.35281111385754665,,Neutral,,Neutral,,1.0155486129852862,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.4148,1.0688,-22.1111,-6.7913130174839,0.8133161677525892,Pathogenic,0.9895,pathogenic,-4.034,available,https://doi.org/10.1101/2022.10.22.513328 +V97L,NP_000537:p.Val97Leu,"hg19,17:g.7579398C>G, hg38,17:g.7676080C>G",,,0.701,"ClinVar,saturation_mutlist",182962,Conflicting classifications of pathogenicity,1,,,,,-0.34955,0.5173994874954224,0.9285733333333331,0.5946226511664642,0.28951166666666656,0.12253632558323208,Neutral,Neutral,Neutral,Neutral,Neutral,0.21726933913019286,0.47450831185788744,0.41387139051043326,-0.48505,-0.3675733333333333,-0.026023098705320796,-0.42631166666666664,-0.2555365493526604,Neutral,Neutral,Neutral,Neutral,0.33976896487008473,0.28955483583242775,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.1848,1.0688,-8.8232,-2.50386002494792,0.0926601665621832,Benign,0.7885,pathogenic,-3.232,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V97M,NP_000537:p.Val97Met,,,,,saturation_mutlist,,,,,,,,-0.39185,0.7183385109901428,,1.225836701869823,,0.4169933509349115,,Neutral,Neutral,,Neutral,0.2563812612612376,,0.6164626287187679,-0.88809,,0.31662950536069717,,-0.28573024731965146,,Neutral,,Neutral,,0.3451932479648038,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.2617,1.0688,-22.1111,-3.33503200257337,0.387817101079041,Uncertain,0.8026,pathogenic,-3.552,available,https://doi.org/10.1101/2022.10.22.513328 +V97N,NP_000537:p.Val97Asn,,,,,saturation_mutlist,,,,,,,,1.07562,1.2105493640899658,,1.6878674208360878,,1.381743710418044,,Neutral,Uncertain,,Neutral,0.44939322197330156,,0.500640737140843,0.35768,,0.6850601678521708,,0.5213700839260854,,Neutral,,Neutral,,0.7469287521608585,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.4064,1.0688,-22.1111,-5.21586743816459,0.3122894778429866,Benign,0.9755,pathogenic,-3.703,available,https://doi.org/10.1101/2022.10.22.513328 +V97P,NP_000537:p.Val97Pro,,,,,saturation_mutlist,,,,,,,,1.43127,0.8840972447395324,,3.8529914909107603,,2.64213074545538,,Uncertain,Neutral,,Uncertain,0.36854830905774355,,1.4057030009649782,1.67342,,3.239444421331621,,2.4564322106658105,,Uncertain,,Uncertain,,1.6598849287227722,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.4563,1.0688,-22.1111,-6.7913130174839,0.6776574615506201,Uncertain,0.9644,pathogenic,-3.582,available,https://doi.org/10.1101/2022.10.22.513328 +V97Q,NP_000537:p.Val97Gln,,,,,saturation_mutlist,,,,,,,,0.51155,0.9660814571380615,,1.9463498889988131,,1.2289499444994065,,Neutral,Neutral,,Neutral,0.36253541426441266,,0.7285416704015013,0.36302,,0.7666636136266819,,0.564841806813341,,Neutral,,Neutral,,0.5779274843410629,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.3865,1.0688,-22.1111,-5.87735687108478,0.6209002658328524,Uncertain,0.9779,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328 +V97R,NP_000537:p.Val97Arg,,,,,saturation_mutlist,,,,,,,,0.52449,0.9889867949485779,,1.8340321633068222,,1.179261081653411,,Neutral,Neutral,,Neutral,0.39084926099466016,,1.2119735106073377,0.16247,,0.5048436522138547,,0.3336568261069274,,Neutral,,Neutral,,0.8155937293608432,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.4358,1.0688,-22.1111,-6.7913130174839,0.7193581657987287,Pathogenic,0.9743,pathogenic,-3.885,available,https://doi.org/10.1101/2022.10.22.513328 +V97S,NP_000537:p.Val97Ser,,,,,saturation_mutlist,,,,,,,,1.39415,0.9547639799118042,,2.2428202520364007,,1.8184851260182002,,Uncertain,Neutral,,Neutral,0.3743322986356302,,0.4323199228042361,0.17563,,1.0141103899937631,,0.5948701949968815,,Neutral,,Neutral,,0.7783379125843934,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.3556,1.0688,-22.1111,-5.20799796771757,0.2389210977172926,Benign,0.9384,pathogenic,-3.55,available,https://doi.org/10.1101/2022.10.22.513328 +V97T,NP_000537:p.Val97Thr,,,,,saturation_mutlist,,,,,,,,0.75723,0.6024078297615051,,1.4629472277461117,,1.110088613873056,,Neutral,Neutral,,Neutral,0.26372406200902215,,0.2087889411641683,0.0756,,0.6969287174889277,,0.38626435874446385,,Neutral,,Neutral,,0.5512739352957112,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.271,1.0688,-22.1111,-5.61453514890981,0.7653631194740931,Pathogenic,0.9119,pathogenic,-3.72,available,https://doi.org/10.1101/2022.10.22.513328 +V97W,NP_000537:p.Val97Trp,,,,,saturation_mutlist,,,,,,,,0.94111,0.7735616183280944,,1.3749503463365864,,1.1580301731682932,,Neutral,Neutral,,Neutral,0.3605164301936631,,1.5333582665916092,1.25221,,-0.07435081612288523,,0.5889295919385574,,Neutral,,Neutral,,0.25411268693802525,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.3697,1.0688,-22.1111,-5.89863134919257,0.8591654982273584,Pathogenic,0.9928,pathogenic,-4.002,available,https://doi.org/10.1101/2022.10.22.513328 +V97Y,NP_000537:p.Val97Tyr,,,,,saturation_mutlist,,,,,,,,0.90529,0.8409518098831177,,1.5040872610226987,,1.2046886305113493,,Neutral,Neutral,,Neutral,0.37418540579651044,,1.4453931793219492,0.42377,,0.23287143338172953,,0.32832071669086477,,Neutral,,Neutral,,0.26492045026073247,50.183,16.883,32.95,26.271,,False,50.183,,neutral,neutral,neutral,,False,32.95,,neutral,neutral,neutral,uncertain,,-0.3048,1.0688,-8.8232,-5.89863134919257,0.4040249311190922,Uncertain,0.9762,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328 +P98A,NP_000537:p.Pro98Ala,"hg19,17:g.7579395G>C, hg38,17:g.7676077G>C",,,0.935,"ClinVar,saturation_mutlist",1039474,Uncertain significance,2,,,,,2.0859,0.5594542956352234,1.3369600000000001,0.2965316508097364,1.71143,1.1912158254048681,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.2592278675100663,0.37973029244451906,0.32472573087679807,2.15949,1.3575966666666666,0.12468685668069568,1.7585433333333333,1.1420884283403478,Uncertain,Uncertain,Neutral,Neutral,0.5540049602866587,0.6435530439200329,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.3233,0.0409,-22.1143,-7.42683667603059,0.8543805855773687,Pathogenic,0.9289,pathogenic,-4.01,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98C,NP_000537:p.Pro98Cys,,,,,saturation_mutlist,,,,,,,,2.14124,0.27349531650543213,,0.8012385639828508,,1.4712392819914253,,Uncertain,Neutral,,Neutral,0.2115373790891954,,0.3711359394580878,2.56234,,0.6793012193252131,,1.6208206096626065,,Uncertain,,Neutral,,0.3844993023910043,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,uncertain,,-0.356,0.0409,-22.1143,-7.42683667603059,0.8705056719051573,Pathogenic,0.9931,pathogenic,-4.181,available,https://doi.org/10.1101/2022.10.22.513328 +P98D,NP_000537:p.Pro98Asp,,,,,saturation_mutlist,,,,,,,,2.09089,1.0726451110839843,,0.8829763209824035,,1.4869331604912017,,Uncertain,Uncertain,,Neutral,0.2007379007375627,,0.6715082336264456,2.31879,,0.29079522310615213,,1.3047926115530761,,Uncertain,,Neutral,,0.908688990227658,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,uncertain,,-0.3819,0.0409,-22.1143,-6.84653774232336,0.8167415408671135,Pathogenic,0.9994,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328 +P98E,NP_000537:p.Pro98Glu,,,,,saturation_mutlist,,,,,,,,1.49305,0.5440798377990723,,0.7340145861969855,,1.1135322930984928,,Neutral,Neutral,,Neutral,0.26833578617496684,,0.6304447004189674,2.58829,,0.08789846613876197,,1.338094233069381,,Uncertain,,Neutral,,0.7568906893779206,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.3657,0.0409,-22.1143,-6.6768897355542,0.7405995680697558,Pathogenic,0.9979,pathogenic,-4.106,available,https://doi.org/10.1101/2022.10.22.513328 +P98F,NP_000537:p.Pro98Phe,"hg38,17:g.7676076_7676077delinsAA",,,,"COSMIC,saturation_mutlist",,,,,,,,1.15032,0.5171791958808899,1.3380933333333331,-0.3370847279196556,1.2442066666666665,0.4066176360401722,Neutral,Neutral,Neutral,Neutral,Neutral,0.31972492705463235,1.077594589485716,0.5911075630688831,3.04441,0.71769,-0.7700875420961694,1.88105,1.1371612289519153,Uncertain,Uncertain,Neutral,Neutral,0.9509830516190426,0.2745941661717847,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.3844,0.0409,-22.1143,-6.84653774232336,0.8694766006891228,Pathogenic,0.9973,pathogenic,-4.214,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98G,NP_000537:p.Pro98Gly,,,,,saturation_mutlist,,,,,,,,3.01877,0.9652582681179047,,1.5262422822565966,,2.2725061411282983,,Uncertain,Neutral,,Uncertain,0.2351364585982832,,0.4023753029106141,2.45956,,1.1606225104280803,,1.8100912552140402,,Uncertain,,Neutral,,0.8310329247158336,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.3376,0.0409,-22.1143,-7.42683667603059,0.8606228671379441,Pathogenic,0.9947,pathogenic,-4.171,available,https://doi.org/10.1101/2022.10.22.513328 +P98H,NP_000537:p.Pro98His,"hg19,17:g.7579394G>T",,,0.953,"cBioPortal,saturation_mutlist",,,,,,,,2.77516,0.974514731168747,1.4411566666666669,0.015630951855988545,2.1081583333333334,1.3953954759279943,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.30129843301486964,0.9566983471061061,0.6128244454787187,4.1118,1.4209733333333334,-0.4230763177057177,2.7663866666666665,1.844361841147141,Uncertain,Uncertain,Uncertain,Neutral,0.9445033690546348,0.46677878103198456,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.362,0.0409,-22.1143,-6.34933447998002,0.6613095857805996,Uncertain,0.9956,pathogenic,-3.911,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98I,NP_000537:p.Pro98Ile,,,,,saturation_mutlist,,,,,,,,1.42042,0.44462985515594483,,-0.35437026667834876,,0.5330248666608256,,Neutral,Neutral,,Neutral,0.33210309695514617,,0.1563834352458057,2.36769,,-0.5094888161569028,,0.9291005919215487,,Uncertain,,Neutral,,0.20480369521009267,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.3674,0.0409,-22.1143,-4.21603750481885,0.2977200543052704,Benign,0.9759,pathogenic,-3.803,available,https://doi.org/10.1101/2022.10.22.513328 +P98K,NP_000537:p.Pro98Lys,,,,,saturation_mutlist,,,,,,,,2.32703,1.1592479014396668,,1.0265580873124411,,1.6767940436562205,,Uncertain,Uncertain,,Neutral,0.22246721379423537,,0.8310012404792132,3.21779,,0.2067864213859283,,1.712288210692964,,Uncertain,,Neutral,,0.4843226397492855,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.3574,0.0409,-22.1143,-7.1769155286079,0.870847769499351,Pathogenic,0.9984,pathogenic,-4.282,available,https://doi.org/10.1101/2022.10.22.513328 +P98L,NP_000537:p.Pro98Leu,"hg19,17:g.7579394G>A, hg19,17:g.7676076G>A, hg38,17:g.7676076G>A",,3.9800361387e-06,0.943,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528236,Conflicting classifications of pathogenicity,1,,,,,1.28624,0.42764074563980103,0.5331066666666667,-0.6968985233275813,0.9096733333333333,0.2946707383362094,Neutral,Neutral,Neutral,Neutral,Neutral,0.2621384645477121,1.1920882008848543,0.3043416831872713,1.48466,-0.09965999999999998,-1.0349998479406386,0.6925,0.22483007602968075,Neutral,Neutral,Neutral,Neutral,0.6382933421241366,0.2586229225090326,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.2991,0.0409,-7.8265,-3.6959843729838,0.0020796179803121,Benign,0.9328,pathogenic,-3.484,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98M,NP_000537:p.Pro98Met,,,,,saturation_mutlist,,,,,,,,0.90455,0.3887704563140869,,-0.2789916121743854,,0.3127791939128073,,Neutral,Neutral,,Neutral,0.28675859873964504,,0.3023718191681082,1.45273,,-0.6678841603889841,,0.392422919805508,,Neutral,,Neutral,,0.18077507132221307,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.323,0.0409,-22.1143,-5.97545587041913,0.7827002118195212,Pathogenic,0.9929,pathogenic,-4.135,available,https://doi.org/10.1101/2022.10.22.513328 +P98N,NP_000537:p.Pro98Asn,,,,,saturation_mutlist,,,,,,,,2.61326,1.128907687664032,,0.409085467997285,,1.5111727339986425,,Uncertain,Uncertain,,Neutral,0.21754283377235073,,0.40447200992527255,2.95985,,0.08281615844158709,,1.5213330792207935,,Uncertain,,Neutral,,0.5657134399075421,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,uncertain,,-0.35,0.0409,-22.1143,-6.84653774232336,0.85224232949847,Pathogenic,0.9989,pathogenic,-4.085,available,https://doi.org/10.1101/2022.10.22.513328 +P98Q,NP_000537:p.Pro98Gln,,,,,saturation_mutlist,,,,,,,,2.26258,0.9202240538597107,,0.45040735813439126,,1.3564936790671955,,Uncertain,Neutral,,Neutral,0.2572107044179665,,0.4256690314130996,2.98628,,0.029599590660395053,,1.5079397953301974,,Uncertain,,Neutral,,0.4371107952767552,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.3517,0.0409,-22.1143,-6.69160345532609,0.4893438202432831,Uncertain,0.9956,pathogenic,-3.853,available,https://doi.org/10.1101/2022.10.22.513328 +P98R,NP_000537:p.Pro98Arg,"hg19,17:g.7579394G>C, hg38,17:g.7676076G>C",,,0.955,"ClinVar,saturation_mutlist",1444043,Uncertain significance,2,,,,,2.90073,1.1766685342788696,2.6854866666666664,0.5504347751907896,2.793108333333333,1.7255823875953946,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.2534328285325555,1.1861862820072666,0.5537896866966645,3.87678,2.481856666666667,-0.18186923699379262,3.1793183333333337,1.8474553815031038,Uncertain,Uncertain,Destabilizing,Neutral,0.8112268904703679,0.2154243812841527,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.3931,0.0409,-22.1143,-6.74972083521465,0.8555864794873003,Pathogenic,0.9928,pathogenic,-4.085,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98S,NP_000537:p.Pro98Ser,"hg19,17:g.7579395G>A, hg19,17:g.7579395_7579396delinsAA, hg19,17:g.7676077G>A, hg38,17:g.7676077G>A, hg38,17:g.7676077_7676078delinsAA",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",822279,Uncertain significance,2,,,,,2.78085,0.8208862340450287,2.1570300000000002,0.736353161679388,2.46894,1.758601580839694,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.21567245707090085,0.48110229293432677,0.31665032986856745,2.82225,1.8125833333333332,0.4170340454291628,2.3174166666666665,1.6196420227145814,Uncertain,Uncertain,Uncertain,Neutral,0.35317516639134694,0.781235680910526,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.323,0.0409,-22.1143,-7.42683667603059,0.6184060215368166,Uncertain,0.9911,pathogenic,-3.766,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98T,NP_000537:p.Pro98Thr,"hg19,17:g.7579395G>T, hg38,17:g.7676077G>T",,,0.957,"COSMIC,ClinVar,saturation_mutlist",1465351,Uncertain significance,1,,,,,2.40379,0.8738442802429199,1.9060100000000002,0.45256029359143285,2.1549,1.4281751467957164,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.27063075240602263,0.2962187031007102,0.21571563850409722,3.2446,1.6569166666666668,0.19540044982636384,2.4507583333333334,1.720000224913182,Uncertain,Uncertain,Uncertain,Neutral,0.6436073847894815,0.43448274724406183,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,uncertain,,-0.3351,0.0409,-22.1143,-7.42683667603059,0.7727350216441489,Pathogenic,0.9793,pathogenic,-3.927,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98V,NP_000537:p.Pro98Val,,,,,saturation_mutlist,,,,,,,,1.6898,0.5997038793563843,,-0.1554388585541995,,0.7671805707229002,,Neutral,Neutral,,Neutral,0.3137384786933269,,0.25155752952004057,2.32654,,-0.3254479918226436,,1.0005460040886782,,Uncertain,,Neutral,,0.10173286623052792,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.3228,0.0409,-22.1143,-5.07190444507632,0.2041897478568988,Benign,0.9425,pathogenic,-3.734,available,https://doi.org/10.1101/2022.10.22.513328 +P98W,NP_000537:p.Pro98Trp,,,,,saturation_mutlist,,,,,,,,1.75135,0.5287522292137146,,-0.4520406367213279,,0.649654681639336,,Neutral,Neutral,,Neutral,0.33614474756899165,,0.7580558476596525,4.54408,,-1.056215654009743,,1.7439321729951285,,Uncertain,,Neutral,,0.32469509331226687,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.3969,0.0409,-22.1143,-6.84653774232336,0.8582450526562,Pathogenic,0.999,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +P98Y,NP_000537:p.Pro98Tyr,,,,,saturation_mutlist,,,,,,,,1.42491,0.516578061580658,,-0.16313974302850642,,0.6308851284857467,,Neutral,Neutral,,Neutral,0.3355711412204278,,0.6557570031658898,3.65706,,-0.5923795919804903,,1.532340204009755,,Uncertain,,Neutral,,0.30573382936216853,18.604,7.342,21.81,12.717,,False,18.604,,neutral,neutral,neutral,,False,21.81,,neutral,neutral,neutral,damaging,,-0.3854,0.0409,-22.1143,-6.84653774232336,0.8249436729842745,Pathogenic,0.9982,pathogenic,-4.174,available,https://doi.org/10.1101/2022.10.22.513328 +S99A,NP_000537:p.Ser99Ala,,,,,saturation_mutlist,,,,,,,,-0.07516,0.6902195835113525,,0.2705119916179931,,0.09767599580899655,,Neutral,Neutral,,Neutral,0.2499457054223446,,0.21881107938535613,-0.12665,,0.3094318874947751,,0.09139094374738756,,Neutral,,Neutral,,0.1809376829026142,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.1339,0.8482,-8.8168,-2.03662347596349,0.0021624643995575,Benign,0.1293,benign,-3.26,available,https://doi.org/10.1101/2022.10.22.513328 +S99C,NP_000537:p.Ser99Cys,"hg19,17:g.7579391G>C, hg38,17:g.7676073G>C",,,0.729,"ClinVar,saturation_mutlist",566954,Uncertain significance,1,,,,,0.00654,0.4194465398788452,0.7098633333333334,0.9017605714526745,0.3582016666666667,0.45415028572633726,Neutral,Neutral,Neutral,Neutral,Neutral,0.2582753315666164,0.3187306953457033,0.05402136857475682,0.12863,-0.03832,0.8942229611133296,0.045155,0.5114264805566647,Neutral,Neutral,Neutral,Neutral,0.13710312712212902,0.0758788764759873,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.1793,0.8482,-7.8169,-2.10999191868723,0.0592506188520818,Benign,0.1223,benign,-3.364,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S99D,NP_000537:p.Ser99Asp,,,,,saturation_mutlist,,,,,,,,-0.89083,0.018152902126312258,,-0.011310192767148092,,-0.45107009638357404,,Neutral,Neutral,,Neutral,0.3417360078496061,,0.24860333238056312,-0.30796,,-0.020014262128116467,,-0.16398713106405824,,Neutral,,Neutral,,0.1291463840865037,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.3004,0.8482,-22.1047,-4.99000117418982,0.4866656516797909,Uncertain,0.9326,pathogenic,-3.761,available,https://doi.org/10.1101/2022.10.22.513328 +S99E,NP_000537:p.Ser99Glu,,,,,saturation_mutlist,,,,,,,,-0.61799,0.5562928199768067,,-0.010847248457531896,,-0.314418624228766,,Neutral,Neutral,,Neutral,0.40213120510709655,,0.2054045589158066,-0.31431,,-0.10080540351465532,,-0.20755770175732766,,Neutral,,Neutral,,0.17294087989996418,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.1956,0.8482,-6.817,-3.24842132571137,0.0764739357484207,Benign,0.9424,pathogenic,-3.504,available,https://doi.org/10.1101/2022.10.22.513328 +S99F,NP_000537:p.Ser99Phe,"hg19,17:g.7579391G>A, hg38,17:g.7676073G>A",,,0.748,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",579376,Uncertain significance,1,,,,,-0.18742,1.2009022521972657,0.053743333333333386,-0.07466892668904379,-0.0668383333333333,-0.1310444633445219,Neutral,Neutral,Uncertain,Neutral,Neutral,0.3458879512676501,0.9658779407472884,0.13446101991219284,-0.25745,-0.24795999999999999,-0.14112826109985302,-0.252705,-0.19928913054992653,Neutral,Neutral,Neutral,Neutral,0.37895068289510536,0.10936571377854115,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.212,0.8482,-8.8168,-4.37964932676007,0.4768589392004329,Uncertain,0.7366,pathogenic,-3.593,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S99G,NP_000537:p.Ser99Gly,,,,,saturation_mutlist,,,,,,,,0.24385,0.9982188379764557,,0.8449235535106343,,0.5443867767553172,,Neutral,Neutral,,Neutral,0.22331450146751577,,0.12427190596247487,-0.98919,,0.8010734317485753,,-0.09405828412571238,,Neutral,,Neutral,,0.038777488780713285,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.2109,0.8482,-22.1047,-5.29168757840173,0.2486192389644271,Benign,0.3498,ambiguous,-3.646,available,https://doi.org/10.1101/2022.10.22.513328 +S99H,NP_000537:p.Ser99His,,,,,saturation_mutlist,,,,,,,,0.2295,0.9771358323097229,,-0.12188109751456176,,0.053809451242719124,,Neutral,Neutral,,Neutral,0.350830368028605,,0.166869853161427,0.41509,,-0.2097898722856946,,0.10265006385715271,,Neutral,,Neutral,,0.11262253657934539,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.281,0.8482,-22.1047,-5.94757588828271,0.7705282874957041,Pathogenic,0.8773,pathogenic,-3.852,available,https://doi.org/10.1101/2022.10.22.513328 +S99I,NP_000537:p.Ser99Ile,,,,,saturation_mutlist,,,,,,,,-0.0215,1.1388525342941285,,-0.04688101523574387,,-0.03419050761787193,,Neutral,Uncertain,,Neutral,0.3500110647887783,,0.20419057218570083,0.21483,,0.028527044444653354,,0.12167852222232667,,Neutral,,Neutral,,0.22746454534467805,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.207,0.8482,-7.232,-2.51138486296729,0.0365380203993881,Benign,0.5937,pathogenic,-3.462,available,https://doi.org/10.1101/2022.10.22.513328 +S99K,NP_000537:p.Ser99Lys,,,,,saturation_mutlist,,,,,,,,-0.02261,1.1833197951316834,,0.18098296547997772,,0.07918648273998886,,Neutral,Uncertain,,Neutral,0.3392041996664863,,0.17489485042280084,-0.12829,,0.0423849256187279,,-0.04295253719063605,,Neutral,,Neutral,,0.13250572752420287,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.2904,0.8482,-22.1047,-6.07159955555084,0.6238491921797358,Uncertain,0.99,pathogenic,-3.782,available,https://doi.org/10.1101/2022.10.22.513328 +S99L,NP_000537:p.Ser99Leu,,,,,saturation_mutlist,,,,,,,,-0.37542,1.0442086577415466,,-0.2931469609543167,,-0.33428348047715833,,Neutral,Uncertain,,Neutral,0.37036353764452273,,0.1300553961277521,-0.33513,,-0.2884069200795429,,-0.31176846003977143,,Neutral,,Neutral,,0.14926820950638492,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.2792,0.8482,-22.1047,-4.6524473906565,0.3152760368332274,Benign,0.3848,ambiguous,-3.654,available,https://doi.org/10.1101/2022.10.22.513328 +S99M,NP_000537:p.Ser99Met,,,,,saturation_mutlist,,,,,,,,-0.4212,1.035605607032776,,0.08801507507304089,,-0.16659246246347956,,Neutral,Uncertain,,Neutral,0.2922345247371878,,0.16542724156256314,-0.48066,,0.057688417523859004,,-0.2114857912380705,,Neutral,,Neutral,,0.09634576225046414,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.2503,0.8482,-22.1047,-4.6524473906565,0.6108603232935785,Uncertain,0.6321,pathogenic,-3.876,available,https://doi.org/10.1101/2022.10.22.513328 +S99N,NP_000537:p.Ser99Asn,,,,,saturation_mutlist,,,,,,,,-0.06061,0.36164040803909303,,0.14276933628389812,,0.04107966814194906,,Neutral,Neutral,,Neutral,0.2781743346628796,,0.1776668428705184,0.00161,,0.12476280527236276,,0.06318640263618137,,Neutral,,Neutral,,0.057596423511074524,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.1562,0.8482,-8.8168,-2.15050162545049,0.0412081491495104,Benign,0.6939,pathogenic,-3.624,available,https://doi.org/10.1101/2022.10.22.513328 +S99P,NP_000537:p.Ser99Pro,"hg38,17:g.7676074A>G",,,0.730,"COSMIC,saturation_mutlist",,,,,,,,-0.74514,0.9405597257614136,-0.8535133333333332,1.200367181011967,-0.7993266666666666,0.22761359050598345,Neutral,Neutral,Neutral,Neutral,Neutral,0.4394980732952844,1.1531148428592106,0.22932133670451624,0.39379,-0.14524000000000004,1.1655677396608883,0.12427499999999997,0.7796788698304442,Neutral,Neutral,Neutral,Neutral,1.2112598840050801,0.5645973246516487,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.2793,0.8482,-7.232,-3.58565861016749,0.004222359358517,Benign,0.4968,ambiguous,-3.298,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S99Q,NP_000537:p.Ser99Gln,,,,,saturation_mutlist,,,,,,,,-0.17751,0.9620955419540406,,0.29233380778007695,,0.057411903890038474,,Neutral,Neutral,,Neutral,0.36103966196679105,,0.18762832765842927,-0.09756,,0.23054298021600247,,0.06649149010800123,,Neutral,,Neutral,,0.1082445847619438,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.2437,0.8482,-22.1047,-5.3245344443721,0.8169297351414572,Pathogenic,0.9232,pathogenic,-3.706,available,https://doi.org/10.1101/2022.10.22.513328 +S99R,NP_000537:p.Ser99Arg,,,,,saturation_mutlist,,,,,,,,0.18988,1.201737084388733,,0.033705074317461836,,0.11179253715873091,,Neutral,Uncertain,,Neutral,0.30635879467565735,,0.14868756932154487,0.02486,,-0.0494790288911414,,-0.012309514445570699,,Neutral,,Neutral,,0.12035223931680497,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.2956,0.8482,-22.1047,-6.07159955555084,0.5342846203214724,Uncertain,0.9759,pathogenic,-3.811,available,https://doi.org/10.1101/2022.10.22.513328 +S99T,NP_000537:p.Ser99Thr,,,,,saturation_mutlist,,,,,,,,0.14542,0.561167631149292,,0.2544042668721123,,0.19991213343605616,,Neutral,Neutral,,Neutral,0.14808606732347596,,0.23503774339622438,0.31367,,0.1609641295483634,,0.23731706477418169,,Neutral,,Neutral,,0.08274834986170622,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,neutral,neutral,uncertain,P,False,61.13,-0.049,neutral,neutral,uncertain,uncertain,,-0.107,0.8482,-5.3575,-1.68878551671982,0.0002817515312688,Benign,0.2426,benign,-3.098,available,https://doi.org/10.1101/2022.10.22.513328 +S99V,NP_000537:p.Ser99Val,,,,,saturation_mutlist,,,,,,,,0.22275,1.1080391693115235,,0.04475136661447334,,0.13375068330723666,,Neutral,Uncertain,,Neutral,0.388709954519599,,0.2830706109271355,0.45866,,0.11381592820161136,,0.2862379641008057,,Neutral,,Neutral,,0.1920034354251096,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.1632,0.8482,-3.6877,-2.56319182008455,0.0001888167233907,Benign,0.4336,ambiguous,-3.176,available,https://doi.org/10.1101/2022.10.22.513328 +S99W,NP_000537:p.Ser99Trp,,,,,saturation_mutlist,,,,,,,,-0.13504,1.0451283693313598,,-0.544839378692478,,-0.33993968934623897,,Neutral,Uncertain,,Neutral,0.3627903468428869,,0.12522742456965738,-0.10571,,-0.5375607388707494,,-0.3216353694353747,,Neutral,,Neutral,,0.05561963130068325,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,damaging,neutral,uncertain,P,False,61.13,-0.049,damaging,neutral,uncertain,uncertain,,-0.2895,0.8482,-22.1047,-5.94757588828271,0.8504665046761357,Pathogenic,0.8337,pathogenic,-3.997,available,https://doi.org/10.1101/2022.10.22.513328 +S99Y,NP_000537:p.Ser99Tyr,,,,,saturation_mutlist,,,,,,,,-0.11076,1.320691921710968,,0.020370624249861007,,-0.04519468787506949,,Neutral,Uncertain,,Neutral,0.42129857472396703,,0.15977106023791232,-0.14798,,-0.0920299877394276,,-0.1200049938697138,,Neutral,,Neutral,,0.11724190340588993,47.049,8.11,61.13,20.703,P,False,47.049,-0.626,uncertain,neutral,uncertain,P,False,61.13,-0.049,uncertain,neutral,uncertain,uncertain,,-0.2846,0.8482,-22.1047,-5.94757588828271,0.764746975734436,Pathogenic,0.7584,pathogenic,-3.759,available,https://doi.org/10.1101/2022.10.22.513328 +Q100A,NP_000537:p.Gln100Ala,,,,,saturation_mutlist,,,,,,,,0.53635,0.24139925122261047,,0.713336772686446,,0.624843386343223,,Neutral,Neutral,,Neutral,0.19788799806286023,,0.35716501258326,0.25881,,0.6876306712084063,,0.4732203356042031,,Neutral,,Neutral,,0.2435876856793568,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,uncertain,,-0.0681,1.6191,-6.0096,-2.18617788994892,5.692926200753552e-05,Benign,0.1818,benign,-3.076,available,https://doi.org/10.1101/2022.10.22.513328 +Q100C,NP_000537:p.Gln100Cys,,,,,saturation_mutlist,,,,,,,,0.432,-0.03440396785736085,,0.9451550577425966,,0.6885775288712983,,Neutral,Neutral,,Neutral,0.1962453948208919,,0.21001719210945655,-0.25006,,0.928050265675652,,0.338995132837826,,Neutral,,Neutral,,0.0906935437814896,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,uncertain,,-0.1964,1.6191,-22.1047,-2.88359836349613,0.2089232186451173,Benign,0.6333,pathogenic,-3.406,available,https://doi.org/10.1101/2022.10.22.513328 +Q100D,NP_000537:p.Gln100Asp,,,,,saturation_mutlist,,,,,,,,0.50565,0.652005980014801,,1.4451876425870769,,0.9754188212935384,,Neutral,Neutral,,Neutral,0.330920155666761,,0.36336962527159217,0.58839,,1.7500869566365538,,1.169238478318277,,Neutral,,Neutral,,0.06723135108859307,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,uncertain,,-0.2368,1.6191,-22.1047,-3.61352347944445,0.0160879456823056,Benign,0.5576,ambiguous,-3.404,available,https://doi.org/10.1101/2022.10.22.513328 +Q100E,NP_000537:p.Gln100Glu,,,,,saturation_mutlist,,,,,,,,0.21255,0.5345196151733398,,0.9544537836578219,,0.5835018918289109,,Neutral,Neutral,,Neutral,0.21416022650622624,,0.4699779450539961,0.33699,,1.2041244042974026,,0.7705572021487013,,Neutral,,Neutral,,0.12670578400938745,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,uncertain,,-0.0875,1.6191,-8.8168,-0.717685804355302,0.1871007659875273,Benign,0.1196,benign,-3.386,available,https://doi.org/10.1101/2022.10.22.513328 +Q100F,NP_000537:p.Gln100Phe,,,,,saturation_mutlist,,,,,,,,-0.11589,0.22211444973945618,,-0.2925720686924899,,-0.20423103434624496,,Neutral,Neutral,,Neutral,0.30744667247631924,,0.46472121868629174,0.47857,,-0.472981257426643,,0.002794371286678504,,Neutral,,Neutral,,0.46164334740457785,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,neutral,,-0.2045,1.6191,-22.1047,-5.32766260795124,0.2126188911746656,Benign,0.74,pathogenic,-3.447,available,https://doi.org/10.1101/2022.10.22.513328 +Q100G,NP_000537:p.Gln100Gly,,,,,saturation_mutlist,,,,,,,,1.05079,0.8630686330795289,,1.919310164220623,,1.4850500821103114,,Neutral,Neutral,,Neutral,0.3166930442275946,,0.30698018294417084,0.86015,,2.142230285600172,,1.501190142800086,,Uncertain,,Neutral,,0.06388859356351027,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,uncertain,,-0.2209,1.6191,-22.1047,-6.16409717367653,0.2567840028423017,Benign,0.258,benign,-3.484,available,https://doi.org/10.1101/2022.10.22.513328 +Q100H,NP_000537:p.Gln100His,"hg38,17:g.7676069C>G",,,0.417,"COSMIC,saturation_mutlist",,,,,,,,0.6297,0.3036530017852783,0.09501,0.3099820321011138,0.36235500000000004,0.46984101605055695,Neutral,Neutral,Neutral,Neutral,Neutral,0.30830696085685017,0.22929937679810647,0.39303178381507997,1.04471,0.13344333333333333,0.365332907298181,0.5890766666666667,0.7050214536490905,Neutral,Neutral,Neutral,Neutral,0.36038888831680455,0.2846168190269727,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,neutral,,-0.0754,1.6191,-7.232,-2.00345320419082,0.0089012761372089,Benign,0.2951,benign,-3.194,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q100I,NP_000537:p.Gln100Ile,,,,,saturation_mutlist,,,,,,,,-0.20165,-0.279199583530426,,-0.5271540980633339,,-0.36440204903166695,,Neutral,Neutral,,Neutral,0.4406106788928164,,0.12246388794026437,-0.64533,,-0.2988185948103768,,-0.47207429740518836,,Neutral,,Neutral,,0.2851565246540486,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,neutral,,-0.1129,1.6191,-7.8169,-3.42875722247119,4.14873840206641e-06,Benign,0.4695,ambiguous,-3.174,available,https://doi.org/10.1101/2022.10.22.513328 +Q100K,NP_000537:p.Gln100Lys,"hg38,17:g.7676071G>T",,,0.541,"COSMIC,saturation_mutlist",,,,,,,,0.03698,0.4101547145843506,0.5030633333333334,0.7744248586466996,0.2700216666666667,0.4057024293233498,Neutral,Neutral,Neutral,Neutral,Neutral,0.20477883269279215,0.47920742762282903,0.3859169796965351,-0.2151,0.7091833333333334,1.187805087501548,0.2470416666666667,0.48635254375077397,Neutral,Neutral,Neutral,Neutral,0.5005797345966864,0.28135561710851276,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,neutral,,-0.1834,1.6191,-22.1047,-4.73372398165281,0.0139138946762343,Benign,0.2262,benign,-3.368,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q100L,NP_000537:p.Gln100Leu,,,,,saturation_mutlist,,,,,,,,-0.74435,-0.04308038949966431,,-0.618015778538768,,-0.681182889269384,,Neutral,Neutral,,Neutral,0.4161069542131695,,0.2207932700044952,-0.72985,,-0.6762751978212299,,-0.703062598910615,,Neutral,,Neutral,,0.21780237094619356,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,neutral,,-0.1692,1.6191,-22.1047,-4.64850701981391,0.0005393629436839,Benign,0.1766,benign,-3.162,available,https://doi.org/10.1101/2022.10.22.513328 +Q100M,NP_000537:p.Gln100Met,,,,,saturation_mutlist,,,,,,,,-1.00189,-0.12318487644195557,,-0.1356442543829661,,-0.568767127191483,,Neutral,Neutral,,Neutral,0.2962996757971751,,0.31031060704904107,-1.01966,,-0.32419051981221797,,-0.671925259906109,,Neutral,,Neutral,,0.19595636936218258,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,neutral,,-0.1401,1.6191,-22.1047,-4.64770521564569,0.0458879245734926,Benign,0.3977,ambiguous,-3.415,available,https://doi.org/10.1101/2022.10.22.513328 +Q100N,NP_000537:p.Gln100Asn,,,,,saturation_mutlist,,,,,,,,0.50931,0.6445599722862244,,0.8240650408765617,,0.666687520438281,,Neutral,Neutral,,Neutral,0.29277587177331266,,0.12545535726310433,0.3202,,0.9256990234661951,,0.6229495117330975,,Neutral,,Neutral,,0.1418000888059581,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,uncertain,,-0.0566,1.6191,-0.6826,-2.21247686266912,0.0003023702975909,Benign,0.3288,benign,-3.028,available,https://doi.org/10.1101/2022.10.22.513328 +Q100P,NP_000537:p.Gln100Pro,"hg19,17:g.7579388T>G, hg38,17:g.7676070T>G",,,0.398,"ClinVar,saturation_mutlist",4189274,Uncertain significance,1,,,,,0.14896,0.7108706140518188,,2.8145398724391626,,1.4817499362195814,,Uncertain,Neutral,,Neutral,0.49645918264941497,,0.49133140765679795,0.35223,,2.6723213173729516,,1.5122756586864758,,Uncertain,,Neutral,,0.35106384102424987,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,uncertain,,-0.2417,1.6191,-6.0096,-1.80610282178611,0.0011713282289131,Benign,0.0763,benign,-3.077,available,https://doi.org/10.1101/2022.10.22.513328 +Q100R,NP_000537:p.Gln100Arg,,,,,"COSMIC,saturation_mutlist",,,,,,,,0.27629,0.4796799612045288,,0.17660356514858552,,0.22644678257429274,,Neutral,Neutral,,Neutral,0.1996390913394353,,0.300600122991844,0.03419,,0.5007335548347257,,0.2674617774173629,,Neutral,,Neutral,,0.27984779509482,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,neutral,,-0.1819,1.6191,-22.1047,-2.23543971919887,0.0024610908094535,Benign,0.2143,benign,-3.19,available,https://doi.org/10.1101/2022.10.22.513328 +Q100S,NP_000537:p.Gln100Ser,,,,,saturation_mutlist,,,,,,,,0.92378,0.2176594042778015,,1.1475954744056047,,1.0356877372028024,,Neutral,Neutral,,Neutral,0.19781666235679427,,0.2305092651385062,0.45468,,1.2679445603183386,,0.8613122801591693,,Neutral,,Neutral,,0.12687913454999272,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,uncertain,,-0.0957,1.6191,-7.8169,-2.49194687406266,0.0003890251057128,Benign,0.2055,benign,-3.058,available,https://doi.org/10.1101/2022.10.22.513328 +Q100T,NP_000537:p.Gln100Thr,,,,,saturation_mutlist,,,,,,,,0.80515,-0.09374353885650635,,0.5120346157316513,,0.6585923078658257,,Neutral,Neutral,,Neutral,0.1611275667772747,,0.2544109349787267,0.14867,,0.7871281761793366,,0.4678990880896683,,Neutral,,Neutral,,0.15004195335559825,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,uncertain,,-0.0784,1.6191,-2.4771,-2.13481567354687,4.663829191095043e-10,Benign,0.1739,benign,-2.857,available,https://doi.org/10.1101/2022.10.22.513328 +Q100V,NP_000537:p.Gln100Val,,,,,saturation_mutlist,,,,,,,,0.42386,-0.14210495710372925,,-0.293427134276659,,0.0652164328616705,,Neutral,Neutral,,Neutral,0.3049514003497286,,0.17582998904856414,-0.27897,,-0.17847545939677703,,-0.22872272969838853,,Neutral,,Neutral,,0.3202135705746081,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,uncertain,,-0.1859,1.6191,-22.1047,-3.58944580318533,0.0005653868532804,Benign,0.2841,benign,-3.252,available,https://doi.org/10.1101/2022.10.22.513328 +Q100W,NP_000537:p.Gln100Trp,,,,,saturation_mutlist,,,,,,,,-0.00544,0.29563703656196594,,-0.2900057297578563,,-0.14772286487892816,,Neutral,Neutral,,Neutral,0.3325098406331876,,0.5408898916572265,0.93597,,-0.28758613468818917,,0.3241919326559054,,Neutral,,Neutral,,0.4759769448800305,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,neutral,,-0.2038,1.6191,-22.1047,-5.32766260795124,0.4138929597883934,Uncertain,0.6625,pathogenic,-3.876,available,https://doi.org/10.1101/2022.10.22.513328 +Q100Y,NP_000537:p.Gln100Tyr,,,,,saturation_mutlist,,,,,,,,-0.00981,0.30793542742729185,,0.005644293448000844,,-0.0020828532759995778,,Neutral,Neutral,,Neutral,0.3380301474317907,,0.5714566106763843,0.50062,,-0.06849174438506098,,0.21606412780746947,,Neutral,,Neutral,,0.5708770943262813,42.539,10.772,37.065,15.431,,False,42.539,,neutral,neutral,neutral,,False,37.065,,neutral,neutral,neutral,neutral,,-0.1389,1.6191,-8.8168,-2.17950936958216,0.0120768242374196,Benign,0.5987,pathogenic,-3.457,available,https://doi.org/10.1101/2022.10.22.513328 +K101A,NP_000537:p.Lys101Ala,,,,,saturation_mutlist,,,,,,,,0.09733,-0.14727073192596435,,0.30798771893993493,,0.20265885946996748,,Neutral,Neutral,,Neutral,0.08463545674594784,,0.06401408164934017,0.11533,,0.3540533489638691,,0.23469167448193454,,Neutral,,Neutral,,0.13166281728313736,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.0938,1.5495,-5.3575,-1.41278294242254,0.0002667008494202,Benign,0.2711,benign,-3.176,available,https://doi.org/10.1101/2022.10.22.513328 +K101C,NP_000537:p.Lys101Cys,,,,,saturation_mutlist,,,,,,,,0.24075,-0.27837162017822265,,0.8620772568073987,,0.5514136284036993,,Neutral,Neutral,,Neutral,0.06361051995489882,,0.03278290627853679,0.1305,,0.8539482052510236,,0.49222410262551175,,Neutral,,Neutral,,0.16526939660087955,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.2494,1.5495,-22.1047,-2.83150142223143,0.1442606411477681,Benign,0.5815,pathogenic,-3.543,available,https://doi.org/10.1101/2022.10.22.513328 +K101D,NP_000537:p.Lys101Asp,,,,,saturation_mutlist,,,,,,,,-0.25792,-0.1144433259963989,,0.0643017016619411,,-0.09680914916902944,,Neutral,Neutral,,Neutral,0.1034892264167197,,0.17763503774192313,0.1627,,0.307593725804516,,0.235146862902258,,Neutral,,Neutral,,0.19069051427770872,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.2153,1.5495,-7.8169,-1.78334157833635,0.0004086659020461,Benign,0.3363,benign,-3.175,available,https://doi.org/10.1101/2022.10.22.513328 +K101E,NP_000537:p.Lys101Glu,"hg19,17:g.7579386T>C, hg38,17:g.7676068T>C",,,0.503,"ClinVar,saturation_mutlist",1059163,Uncertain significance,2,,,,,-0.29298,-0.3141750645637512,-0.0028333333333333322,-0.019649953329112232,-0.1479066666666667,-0.15631497666455613,Neutral,Neutral,Neutral,Neutral,Neutral,0.09002828913902343,0.08170739759790556,0.14875512603582694,0.19725,-0.5422933333333333,0.16123782633280456,-0.17252166666666663,0.17924391316640229,Neutral,Neutral,Neutral,Neutral,0.34220332867398523,0.22304676895110495,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.1136,1.5495,-4.3576,-1.55515076737838,1.027068838582233e-08,Benign,0.1266,benign,-2.931,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K101F,NP_000537:p.Lys101Phe,,,,,saturation_mutlist,,,,,,,,-0.11131,0.09268260955810545,,-0.07156806001111193,,-0.09143903000555598,,Neutral,Neutral,,Neutral,0.11586371662865759,,0.02984449853084087,0.02478,,-0.3285289879576834,,-0.1518744939788417,,Neutral,,Neutral,,0.0036941942557653915,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.2503,1.5495,-22.1047,-5.044545139671,0.1296852828997438,Benign,0.743,pathogenic,-3.638,available,https://doi.org/10.1101/2022.10.22.513328 +K101G,NP_000537:p.Lys101Gly,,,,,saturation_mutlist,,,,,,,,0.32631,0.31916326880455015,,0.799686574996409,,0.5629982874982045,,Neutral,Neutral,,Neutral,0.10245002407331165,,0.15287426147555538,-0.01855,,1.119933081651997,,0.5506915408259985,,Neutral,,Neutral,,0.17812371210273875,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.2384,1.5495,-22.1047,-5.044545139671,0.0630054781695485,Benign,0.3471,ambiguous,-3.56,available,https://doi.org/10.1101/2022.10.22.513328 +K101H,NP_000537:p.Lys101His,,,,,saturation_mutlist,,,,,,,,0.22837,-0.021962125301361067,,-0.10138532977910747,,0.06349233511044626,,Neutral,Neutral,,Neutral,0.068740982267815,,0.07038534011511126,0.50406,,-0.19783932462955342,,0.15311033768522325,,Neutral,,Neutral,,0.046169363342058255,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.1893,1.5495,-22.1047,-5.044545139671,0.0754695084933959,Benign,0.2362,benign,-3.54,available,https://doi.org/10.1101/2022.10.22.513328 +K101I,NP_000537:p.Lys101Ile,,,,,saturation_mutlist,,,,,,,,0.16317,-0.05002819299697875,,-0.1250575778512275,,0.01905621107438625,,Neutral,Neutral,,Neutral,0.13877260250791498,,0.2380110714603133,0.91424,,-0.13881251228025637,,0.38771374385987184,,Neutral,,Neutral,,0.12991420352263308,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.1447,1.5495,-7.8169,-2.45659022353884,0.0086048836997251,Benign,0.385,ambiguous,-3.468,available,https://doi.org/10.1101/2022.10.22.513328 +K101L,NP_000537:p.Lys101Leu,,,,,saturation_mutlist,,,,,,,,0.00418,-0.08104009628295898,,-0.2904069828961795,,-0.14311349144808974,,Neutral,Neutral,,Neutral,0.06977206409661399,,0.08112641259506351,0.26922,,-0.38555409036331384,,-0.05816704518165691,,Neutral,,Neutral,,0.05526677001073367,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.2163,1.5495,-22.1047,-3.87081682865391,0.1795284700789453,Benign,0.3431,ambiguous,-3.452,available,https://doi.org/10.1101/2022.10.22.513328 +K101M,NP_000537:p.Lys101Met,,,,,saturation_mutlist,,,,,,,,-0.04672,0.01767095804214476,,-0.0031721395840481614,,-0.02494606979202408,,Neutral,Neutral,,Neutral,0.05952347375793721,,0.1065686580421112,-0.06788,,-0.04628380896114667,,-0.057081904480573334,,Neutral,,Neutral,,0.09047181762565316,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.1893,1.5495,-22.1047,-4.03369521027091,0.1757486407318587,Benign,0.2284,benign,-3.671,available,https://doi.org/10.1101/2022.10.22.513328 +K101N,NP_000537:p.Lys101Asn,"hg19,17:g.7579384T>A, hg38,17:g.7676066T>A",,,0.340,"COSMIC,ClinVar,saturation_mutlist",237947,Uncertain significance,2,,,,,0.1419,-0.01891967535018921,0.10124666666666667,0.15326516737589777,0.12157333333333334,0.14758258368794888,Neutral,Neutral,Neutral,Neutral,Neutral,0.06978932971567839,0.25968826367182807,0.10885596876488175,0.2234,-0.23934333333333335,0.2147419987017971,-0.007971666666666682,0.21907099935089855,Neutral,Neutral,Neutral,Neutral,0.3650951434291554,0.17323767861542727,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.1154,1.5495,-6.0096,-0.423504332481986,3.157969582789918e-05,Benign,0.2094,benign,-3.058,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K101P,NP_000537:p.Lys101Pro,,,,,saturation_mutlist,,,,,,,,0.67067,1.2440076649188996,,2.1289990179763403,,1.39983450898817,,Uncertain,Uncertain,,Neutral,0.3401619065909096,,0.18717839696262403,2.26426,,2.6534431142259836,,2.458851557112992,,Uncertain,,Uncertain,,0.24668860078739097,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.3535,1.5495,-22.1047,-5.044545139671,0.5014651435306501,Uncertain,0.7863,pathogenic,-3.428,available,https://doi.org/10.1101/2022.10.22.513328 +K101Q,NP_000537:p.Lys101Gln,"hg19,17:g.7579386T>G, hg38,17:g.7676068T>G",,,0.496,"ClinVar,saturation_mutlist",649735,Uncertain significance,1,,,,,0.08794,-0.0861861443519592,-0.4605433333333333,0.23277897770069847,-0.18630166666666664,0.16035948885034923,Neutral,Neutral,Neutral,Neutral,Neutral,0.043318582982959465,0.020365751206921433,0.05365706394662823,0.17352,-0.5573666666666667,0.31376589390094595,-0.19192333333333333,0.24364294695047298,Neutral,Neutral,Neutral,Neutral,0.550624619278466,0.1474694496617226,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.1107,1.5495,-8.8168,-3.04929158452359,2.8260505481364628e-05,Benign,0.1082,benign,-3.09,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K101R,NP_000537:p.Lys101Arg,"hg38,17:g.7676067T>C",,,0.533,"COSMIC,saturation_mutlist",,,,,,,,0.0624,-0.0291162514686584,0.2797066666666667,-0.09119249922187023,0.17105333333333336,-0.014396249610935115,Neutral,Neutral,Neutral,Neutral,Neutral,0.022687781861632377,0.05154012180384866,0.051278102345599895,-0.02975,-0.55669,-0.015715841441106465,-0.29322000000000004,-0.022732920720553232,Neutral,Neutral,Neutral,Neutral,0.4255038098536839,0.12116858838953401,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.045,1.5495,-8.8168,-2.01201884746741,0.1010940881032756,Benign,0.0904,benign,-3.376,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K101S,NP_000537:p.Lys101Ser,,,,,saturation_mutlist,,,,,,,,0.12881,-0.08863111495971678,,0.31477070040338534,,0.2217903502016927,,Neutral,Neutral,,Neutral,0.07729588777596007,,0.12449017962664195,-0.12178,,0.4687032148198765,,0.17346160740993824,,Neutral,,Neutral,,0.19031357859942777,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.0995,1.5495,-4.4951,-0.919910715457033,7.994847169645615e-07,Benign,0.2764,benign,-2.957,available,https://doi.org/10.1101/2022.10.22.513328 +K101T,NP_000537:p.Lys101Thr,,,,,saturation_mutlist,,,,,,,,0.22128,-0.1492582678794861,,0.19241309724367153,,0.20684654862183577,,Neutral,Neutral,,Neutral,0.08968465509599312,,0.0280772928618039,0.82554,,0.30839719624772205,,0.566968598123861,,Neutral,,Neutral,,0.18365237824984318,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.0911,1.5495,-0.527,0.228672834758593,8.761507881911952e-07,Benign,0.1361,benign,-2.942,available,https://doi.org/10.1101/2022.10.22.513328 +K101V,NP_000537:p.Lys101Val,,,,,saturation_mutlist,,,,,,,,0.31946,-0.13509885787963866,,-0.04366866712839532,,0.13789566643580234,,Neutral,Neutral,,Neutral,0.125812492014362,,0.1900345958936408,0.97932,,-0.04744574929870887,,0.4659371253506456,,Neutral,,Neutral,,0.166562465135769,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.1336,1.5495,-8.8168,-3.3297754018702,0.0009384157504541,Benign,0.319,benign,-3.332,available,https://doi.org/10.1101/2022.10.22.513328 +K101W,NP_000537:p.Lys101Trp,,,,,saturation_mutlist,,,,,,,,-0.29601,0.0638469648361206,,-0.37508189990051694,,-0.33554594995025844,,Neutral,Neutral,,Neutral,0.11927517561817597,,0.010747498261350977,0.36564,,-0.6272926536854517,,-0.13082632684272585,,Neutral,,Neutral,,0.0255460309675678,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.2594,1.5495,-22.1047,-5.044545139671,0.440194706840784,Uncertain,0.7555,pathogenic,-3.843,available,https://doi.org/10.1101/2022.10.22.513328 +K101Y,NP_000537:p.Lys101Tyr,,,,,saturation_mutlist,,,,,,,,-0.019,0.07216627359390258,,-0.002080554280850333,,-0.010540277140425167,,Neutral,Neutral,,Neutral,0.12263408956835235,,0.02165591843189629,0.13076,,-0.2535938026166164,,-0.06141690130830821,,Neutral,,Neutral,,0.011899590661492038,74.462,5.411,73.02,8.958,,False,74.462,,neutral,neutral,neutral,,False,73.02,,neutral,neutral,neutral,uncertain,,-0.2352,1.5495,-22.1047,-5.044545139671,0.1473266006431107,Benign,0.5537,ambiguous,-3.654,available,https://doi.org/10.1101/2022.10.22.513328 +T102A,NP_000537:p.Thr102Ala,"hg19,17:g.7579383T>C, hg38,17:g.7676065T>C",,,0.540,"cBioPortal,ClinVar,saturation_mutlist",1799231,Uncertain significance,1,,,,,-0.11059,0.10059569478034973,0.50068,0.2916250055019898,0.19504500000000002,0.09051750275099489,Neutral,Neutral,Neutral,Neutral,Neutral,0.20257771396170068,0.12867376293039176,0.029237445791560467,0.1923,0.3620166666666667,0.3343836231953298,0.27715833333333334,0.2633418115976649,Neutral,Neutral,Neutral,Neutral,0.10544044142969478,0.2885342959397058,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,neutral,,-0.1776,0.7787,-7.8201,-2.53667362556609,4.601691309706785e-07,Benign,0.081,benign,-3.329,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T102C,NP_000537:p.Thr102Cys,,,,,saturation_mutlist,,,,,,,,-0.13798,-0.09238440990447996,,0.7106374062074666,,0.2863287031037333,,Neutral,Neutral,,Neutral,0.18610724478048754,,0.04198462933249879,0.02952,,0.7980149884107589,,0.41376749420537945,,Neutral,,Neutral,,0.08512696987438015,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,neutral,,-0.2863,0.7787,-22.1079,-3.72957941007573,0.0077913507551721,Benign,0.3096,benign,-3.487,available,https://doi.org/10.1101/2022.10.22.513328 +T102D,NP_000537:p.Thr102Asp,,,,,saturation_mutlist,,,,,,,,-0.09454,0.17093733191490174,,0.43052068093084267,,0.16799034046542133,,Neutral,Neutral,,Neutral,0.16561968055363666,,0.16235069906370792,-0.48876,,0.21705322105711558,,-0.1358533894714422,,Neutral,,Neutral,,0.5922469136411174,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.2546,0.7787,-0.2772,-0.29341417681953,4.0300179181996736e-11,Benign,0.2173,benign,-2.924,available,https://doi.org/10.1101/2022.10.22.513328 +T102E,NP_000537:p.Thr102Glu,,,,,saturation_mutlist,,,,,,,,-0.44966,0.1555386459827423,,0.14174832474293866,,-0.15395583762853066,,Neutral,Neutral,,Neutral,0.15888279781149334,,0.08779130114659256,-0.1509,,0.14497343697392936,,-0.0029632815130353207,,Neutral,,Neutral,,0.4679059795222551,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.2736,0.7787,-8.82,-0.77448022992341,8.95023489345923e-08,Benign,0.2262,benign,-3.13,available,https://doi.org/10.1101/2022.10.22.513328 +T102F,NP_000537:p.Thr102Phe,,,,,saturation_mutlist,,,,,,,,-0.27412,0.07749672651290894,,-0.3498425442074371,,-0.3119812721037185,,Neutral,Neutral,,Neutral,0.29436456594199056,,0.10513571167358379,-0.39927,,-0.4223460528585314,,-0.4108080264292657,,Neutral,,Neutral,,0.07021709128069209,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.3577,0.7787,-22.1079,-6.11400723156905,0.1995774092976594,Benign,0.2724,benign,-3.732,available,https://doi.org/10.1101/2022.10.22.513328 +T102G,NP_000537:p.Thr102Gly,,,,,saturation_mutlist,,,,,,,,0.22677,0.4381249713897705,,1.2289985592332335,,0.7278842796166167,,Neutral,Neutral,,Neutral,0.21942613032569036,,0.045961665600366616,0.25734,,1.0493499353101088,,0.6533449676550545,,Neutral,,Neutral,,0.41285274215007467,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,neutral,,-0.324,0.7787,-22.1079,-5.49924079322158,0.0077352815111896,Benign,0.1999,benign,-3.49,available,https://doi.org/10.1101/2022.10.22.513328 +T102H,NP_000537:p.Thr102His,,,,,saturation_mutlist,,,,,,,,0.14484,-0.015830328464508034,,-0.18512220072765706,,-0.020141100363828532,,Neutral,Neutral,,Neutral,0.25025525486069417,,0.08789913870182424,0.30604,,-0.13913263786643942,,0.08345368106678028,,Neutral,,Neutral,,0.25017147767121173,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.338,0.7787,-22.1079,-6.11400723156905,0.1590434294872293,Benign,0.2253,benign,-3.608,available,https://doi.org/10.1101/2022.10.22.513328 +T102I,NP_000537:p.Thr102Ile,"hg19,17:g.7579382G>A, hg38,17:g.7676064G>A",,,0.540,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",186132,Conflicting classifications of pathogenicity,1,,,,,-0.41146,0.046222243309021,-0.17324333333333333,-0.6470229009219525,-0.2923516666666667,-0.5292414504609763,Neutral,Neutral,Neutral,Neutral,Neutral,0.25265555571060855,0.7451532990525432,0.15519782930317866,-0.32454,-0.7040799999999999,-0.40593800267573976,-0.5143099999999999,-0.3652390013378699,Neutral,Neutral,Neutral,Neutral,0.09092999615088522,0.06905876665510421,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.2086,0.7787,-8.82,-1.7672563726994,0.0002468585807571,Benign,0.1692,benign,-3.451,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T102K,NP_000537:p.Thr102Lys,,,,,saturation_mutlist,,,,,,,,-0.66695,0.04729851007461549,,0.027416912219907264,,-0.3197665438900464,,Neutral,Neutral,,Neutral,0.2545803957281532,,0.029027681139952976,-0.18669,,0.19404634038427024,,0.0036781701921351218,,Neutral,,Neutral,,0.3176355354786761,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.3336,0.7787,-22.1079,-4.6592805094973,0.0037484607755643,Benign,0.2343,benign,-3.519,available,https://doi.org/10.1101/2022.10.22.513328 +T102L,NP_000537:p.Thr102Leu,,,,,saturation_mutlist,,,,,,,,-0.6384,0.09696146726608276,,-0.6379954421070896,,-0.6381977210535448,,Neutral,Neutral,,Neutral,0.21947479921186117,,0.21893761668065206,-0.3506,,-0.5806189701921741,,-0.4656094850960871,,Neutral,,Neutral,,0.03227361031864706,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.3283,0.7787,-22.1079,-4.78595872436852,0.0077956004825543,Benign,0.1239,benign,-3.571,available,https://doi.org/10.1101/2022.10.22.513328 +T102M,NP_000537:p.Thr102Met,,,,,saturation_mutlist,,,,,,,,-0.73549,0.18665832042694092,,-0.24468380380728436,,-0.4900869019036422,,Neutral,Neutral,,Neutral,0.20779558029188863,,0.14748578833981016,-0.32809,,-0.17144610982225914,,-0.24976805491112958,,Neutral,,Neutral,,0.04452204735550731,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.2952,0.7787,-22.1079,-5.23266764577074,0.1261336774472302,Benign,0.1054,benign,-3.736,available,https://doi.org/10.1101/2022.10.22.513328 +T102N,NP_000537:p.Thr102Asn,,,,,saturation_mutlist,,,,,,,,-0.08353,0.030599761009216304,,0.19998199318639678,,0.058225996593198395,,Neutral,Neutral,,Neutral,0.20722338114799888,,0.13117414372711367,-0.23612,,0.1688581338487661,,-0.033630933075616945,,Neutral,,Neutral,,0.32599741124790277,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.2332,0.7787,-7.8201,-1.68059276447804,3.99930289927053e-08,Benign,0.0839,benign,-3.058,available,https://doi.org/10.1101/2022.10.22.513328 +T102P,NP_000537:p.Thr102Pro,"hg38,17:g.7676065T>G",,,0.542,"COSMIC,saturation_mutlist",,,,,,,,-0.96979,0.2698954713344574,-0.41848,0.9219746249071776,-0.6941350000000001,-0.023907687546411205,Neutral,Neutral,Neutral,Neutral,Neutral,0.31185859076355893,0.18120284342875712,0.2849346330075401,0.22913,0.013719999999999987,0.9964431488212852,0.12142499999999999,0.6127865744106425,Neutral,Neutral,Neutral,Neutral,0.253243328177993,0.5250388916064822,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.347,0.7787,-8.82,-1.84925043894037,0.0003812711018513,Benign,0.076,benign,-3.216,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T102Q,NP_000537:p.Thr102Gln,,,,,saturation_mutlist,,,,,,,,-0.51441,0.15425633788108825,,0.17077197922967133,,-0.17181901038516434,,Neutral,Neutral,,Neutral,0.1886343439844191,,0.05370801139122726,-0.18386,,0.2549240581841793,,0.03553202909208965,,Neutral,,Neutral,,0.250824547768207,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.3156,0.7787,-22.1079,-2.83482515028166,0.0043069565385371,Benign,0.2215,benign,-3.378,available,https://doi.org/10.1101/2022.10.22.513328 +T102R,NP_000537:p.Thr102Arg,,,,,saturation_mutlist,,,,,,,,-0.78244,0.03912819147109986,,-0.27119159455204933,,-0.5268157972760247,,Neutral,Neutral,,Neutral,0.27132012700671765,,0.03591044545474159,-0.05652,,-0.04471180949657819,,-0.0506159047482891,,Neutral,,Neutral,,0.15842953968973786,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.3364,0.7787,-22.1079,-5.42088161049316,0.0101975091220079,Benign,0.1907,benign,-3.625,available,https://doi.org/10.1101/2022.10.22.513328 +T102S,NP_000537:p.Thr102Ser,"hg19,17:g.7579383T>A, hg38,17:g.7676065T>A",,,0.506,"COSMIC,ClinVar,saturation_mutlist",582041,Conflicting classifications of pathogenicity,1,,,,,0.13624,0.0022730135917663563,0.49206666666666665,0.42770155583175745,0.31415333333333334,0.2819707779158787,Neutral,Neutral,Neutral,Neutral,Neutral,0.1355475803146152,0.11110836792169262,0.10891854236848739,0.28891,0.2647366666666667,0.3556526916868268,0.2768233333333333,0.3222813458434134,Neutral,Neutral,Neutral,Neutral,0.18189856300208151,0.3135972953398878,72.831,8.733,72.26,9.913,,False,72.831,,neutral,,,,False,72.26,,neutral,,,neutral,,-0.2142,0.7787,-22.1079,-3.36761345082637,0.0003386386021109,Benign,0.0959,benign,-3.202,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T102V,NP_000537:p.Thr102Val,,,,,saturation_mutlist,,,,,,,,-0.04487,0.04322817087173462,,-0.4983675905656108,,-0.2716187952828054,,Neutral,Neutral,,Neutral,0.2415960234258261,,0.08024060680199278,0.02489,,-0.24462500118791086,,-0.10986750059395543,,Neutral,,Neutral,,0.08859646125940969,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.2639,0.7787,-22.1079,-4.52719845860018,0.0056103408281058,Benign,0.1517,benign,-3.362,available,https://doi.org/10.1101/2022.10.22.513328 +T102W,NP_000537:p.Thr102Trp,,,,,saturation_mutlist,,,,,,,,-0.1016,-0.020364294052124005,,-0.5973580458023048,,-0.3494790229011524,,Neutral,Neutral,,Neutral,0.2433479910033409,,0.17493648980504398,0.2494,,-0.7061351379006208,,-0.22836756895031038,,Neutral,,Neutral,,0.08584094047135521,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.3506,0.7787,-22.1079,-6.11400723156905,0.1610016449517735,Benign,0.5816,pathogenic,-4.022,available,https://doi.org/10.1101/2022.10.22.513328 +T102Y,NP_000537:p.Thr102Tyr,,,,,saturation_mutlist,,,,,,,,-0.3216,-0.007875945568084712,,-0.2425780262343589,,-0.28208901311717943,,Neutral,Neutral,,Neutral,0.28542931260580623,,0.06309311950544498,-0.28177,,-0.24429530044814074,,-0.2630326502240704,,Neutral,,Neutral,,0.058140597195528665,72.831,8.733,72.26,9.913,,False,72.831,,uncertain,,,,False,72.26,,uncertain,,,uncertain,,-0.3592,0.7787,-22.1079,-6.11400723156905,0.0115111823856887,Benign,0.286,benign,-3.713,available,https://doi.org/10.1101/2022.10.22.513328 +Y103A,NP_000537:p.Tyr103Ala,,,,,saturation_mutlist,,,,,,,,1.02213,1.644378933906555,,1.8421370298204913,,1.4321335149102457,,Neutral,Uncertain,,Neutral,0.26778294096509353,,0.27962007216179297,0.36345,,1.2935740926733643,,0.8285120463366822,,Neutral,,Neutral,,0.11032136493117421,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.4339,0.1909,-22.1174,-7.00222762676875,0.7129020162583346,Pathogenic,0.9126,pathogenic,-4.16,available,https://doi.org/10.1101/2022.10.22.513328 +Y103C,NP_000537:p.Tyr103Cys,"hg19,17:g.7579379T>C, hg19,17:g.7676061T>C",,,0.870,"cBioPortal,saturation_mutlist",,,,,,,,0.73683,0.6469114351272583,1.6052166666666665,2.044296162203128,1.1710233333333333,1.390563081101564,Neutral,Uncertain,Neutral,Neutral,Neutral,0.2198352506782975,0.4968135975952708,0.22852071948905137,0.44276,1.089,1.7722337004486068,0.76588,1.1074968502243034,Neutral,Neutral,Neutral,Neutral,0.21867107734372807,0.029379752144144396,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.4045,0.1909,-22.1174,-7.00222762676875,0.2979773745374425,Benign,0.4456,ambiguous,-4.046,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y103D,NP_000537:p.Tyr103Asp,,,,,saturation_mutlist,,,,,,,,0.54538,1.6004709148406981,,1.7506919579659215,,1.1480359789829606,,Neutral,Uncertain,,Neutral,0.4749583905122631,,0.28073282905451585,0.47853,,1.241830715531216,,0.860180357765608,,Neutral,,Neutral,,0.1471039451794438,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.4481,0.1909,-22.1174,-6.75854480397109,0.4002054800686839,Uncertain,0.8976,pathogenic,-4.168,available,https://doi.org/10.1101/2022.10.22.513328 +Y103E,NP_000537:p.Tyr103Glu,,,,,saturation_mutlist,,,,,,,,0.43269,1.4071141242980958,,1.6226846472111658,,1.027687323605583,,Neutral,Uncertain,,Neutral,0.340111622531945,,0.2937892049989255,0.21733,,1.0182506906450746,,0.6177903453225373,,Neutral,,Neutral,,0.1772298959268502,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.4768,0.1909,-22.1174,-6.75854480397109,0.7301728111065655,Pathogenic,0.9587,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328 +Y103F,NP_000537:p.Tyr103Phe,"hg38,17:g.7676061T>A",,,0.775,"COSMIC,saturation_mutlist",,,,,,,,-0.15262,0.12668982505798337,0.2591833333333333,0.3126905017274362,0.05328166666666666,0.08003525086371809,Neutral,Neutral,Neutral,Neutral,Neutral,0.06023802834533736,0.11075910928176014,0.15997212344329345,-0.08271,0.02154333333333332,0.2794738386823152,-0.030583333333333344,0.09838191934115759,Neutral,Neutral,Neutral,Neutral,0.3951623106465944,0.0380889301403093,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,uncertain,,-0.1985,0.1909,-7.8297,-0.729552418459478,9.846208839618183e-05,Benign,0.1061,benign,-3.347,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y103G,NP_000537:p.Tyr103Gly,,,,,saturation_mutlist,,,,,,,,2.12727,2.4437735891342163,,2.7110431580341117,,2.4191565790170557,,Uncertain,Destabilizing,,Uncertain,0.30882003250988327,,0.35682666600176893,0.95214,,2.3655513705589346,,1.6588456852794673,,Uncertain,,Neutral,,0.08100577654644954,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.5044,0.1909,-22.1174,-7.2459104495664,0.832857019921432,Pathogenic,0.9121,pathogenic,-4.37,available,https://doi.org/10.1101/2022.10.22.513328 +Y103H,NP_000537:p.Tyr103His,"hg19,17:g.7579380A>G",,,0.870,"cBioPortal,saturation_mutlist",,,,,,,,0.77645,1.0142071795463563,0.8176866666666666,0.9842246122097073,0.7970683333333333,0.8803373061048536,Neutral,Neutral,Uncertain,Neutral,Neutral,0.1985244130234759,0.6788513101965374,0.1153550871053099,0.5687,0.2951266666666667,0.7251438672516205,0.43191333333333337,0.6469219336258103,Neutral,Neutral,Neutral,Neutral,0.07706741738388684,0.08812615037636845,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.2585,0.1909,-5.8297,-2.42969434848,0.0015319571692587,Benign,0.4862,ambiguous,-3.426,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y103I,NP_000537:p.Tyr103Ile,,,,,saturation_mutlist,,,,,,,,0.03555,0.5958244013786316,,0.6557296000771147,,0.3456398000385573,,Neutral,Neutral,,Neutral,0.35658161700644436,,0.41333600371804285,-0.07999,,0.28354501472689414,,0.10177750736344707,,Neutral,,Neutral,,0.09519019177661367,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.4459,0.1909,-22.1174,-5.68468001722731,0.6456420435496886,Uncertain,0.831,pathogenic,-4.138,available,https://doi.org/10.1101/2022.10.22.513328 +Y103K,NP_000537:p.Tyr103Lys,,,,,saturation_mutlist,,,,,,,,0.26875,1.7854035091400147,,1.5731364047405745,,0.9209432023702873,,Neutral,Uncertain,,Neutral,0.2819058607757099,,0.2938967529266673,0.15014,,1.1382933709222833,,0.6442166854611416,,Neutral,,Neutral,,0.10178404355319305,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.5021,0.1909,-22.1174,-7.2459104495664,0.7901760025628769,Pathogenic,0.9736,pathogenic,-4.452,available,https://doi.org/10.1101/2022.10.22.513328 +Y103L,NP_000537:p.Tyr103Leu,,,,,saturation_mutlist,,,,,,,,-0.09222,0.8293757891654968,,0.45706360337110485,,0.18242180168555244,,Neutral,Neutral,,Neutral,0.2667505614210947,,0.2376420052966791,-0.28082,,0.24104371274674885,,-0.019888143626625582,,Neutral,,Neutral,,0.07324386743814967,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.423,0.1909,-22.1174,-5.85400116506491,0.4105026359040801,Uncertain,0.8038,pathogenic,-3.969,available,https://doi.org/10.1101/2022.10.22.513328 +Y103M,NP_000537:p.Tyr103Met,,,,,saturation_mutlist,,,,,,,,-0.27152,0.8999616074562072,,0.8843341654280676,,0.30640708271403383,,Neutral,Neutral,,Neutral,0.214221413165091,,0.21400979617769308,-0.14034,,0.6104047293075651,,0.23503236465378252,,Neutral,,Neutral,,0.042243872961603195,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.3751,0.1909,-22.1174,-5.64638090685081,0.2786541650117003,Benign,0.8703,pathogenic,-4.052,available,https://doi.org/10.1101/2022.10.22.513328 +Y103N,NP_000537:p.Tyr103Asn,"hg19,17:g.7579380A>T",,,0.906,"cBioPortal,saturation_mutlist",,,,,,,,0.67529,1.6198706579208375,,1.4175738255385042,,1.046431912769252,,Neutral,Uncertain,,Neutral,0.3364026659432402,,0.2177572063734971,0.65078,,1.1565242283468287,,0.9036521141734144,,Neutral,,Neutral,,0.19131119978251976,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.4271,0.1909,-22.1174,-6.22898701486561,0.6507354763750128,Uncertain,0.7661,pathogenic,-4.121,available,https://doi.org/10.1101/2022.10.22.513328 +Y103P,NP_000537:p.Tyr103Pro,,,,,saturation_mutlist,,,,,,,,5.57559,2.621156539916992,,5.250540903666212,,5.413065451833106,,Destabilizing,Destabilizing,,Destabilizing,0.3364323073815004,,0.23491715468445873,6.09495,,4.286206705695346,,5.190578352847673,,Destabilizing,,Destabilizing,,0.7460501508542133,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.5581,0.1909,-22.1174,-7.2459104495664,0.8257930979447108,Pathogenic,0.9851,pathogenic,-4.284,available,https://doi.org/10.1101/2022.10.22.513328 +Y103Q,NP_000537:p.Tyr103Gln,"hg19,17:g.7579378_7579380delinsCTG, hg38,17:g.7676060_7676062delinsCTG",,,,"ClinVar,saturation_mutlist",3010803,Uncertain significance,1,,,,,0.62051,1.5708830213546754,,1.565373059235614,,1.092941529617807,,Neutral,Uncertain,,Neutral,0.26249727935827455,,0.226443285501861,0.28028,,1.158846425963054,,0.719563212981527,,Neutral,,Neutral,,0.13864598218837895,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.4516,0.1909,-22.1174,-6.75854480397109,0.7517072268343867,Pathogenic,0.9228,pathogenic,-4.211,available,https://doi.org/10.1101/2022.10.22.513328 +Y103R,NP_000537:p.Tyr103Arg,,,,,saturation_mutlist,,,,,,,,0.63374,1.5913194179534913,,1.159268968894376,,0.896504484447188,,Neutral,Uncertain,,Neutral,0.26848307973764374,,0.224354987474118,0.36682,,0.7928451653084422,,0.5798325826542211,,Neutral,,Neutral,,0.04259897712872793,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.4974,0.1909,-22.1174,-7.2459104495664,0.8328124366186256,Pathogenic,0.9142,pathogenic,-4.258,available,https://doi.org/10.1101/2022.10.22.513328 +Y103S,NP_000537:p.Tyr103Ser,"hg19,17:g.7579379T>G, hg38,17:g.7676061T>G",,,0.904,"ClinVar,saturation_mutlist",2729592,Uncertain significance,1,,,,,1.09441,1.6658568453788758,,2.0269100478992716,,1.560660023949636,,Uncertain,Uncertain,,Neutral,0.2996785083779187,,0.3084473775792324,0.82917,,1.4960146651916204,,1.16259233259581,,Neutral,,Neutral,,0.07704370206687712,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.4386,0.1909,-22.1174,-7.00222762676875,0.4076309037514859,Uncertain,0.7037,pathogenic,-3.998,available,https://doi.org/10.1101/2022.10.22.513328 +Y103T,NP_000537:p.Tyr103Thr,,,,,saturation_mutlist,,,,,,,,0.84066,1.4712137007713317,,1.6058600360161648,,1.2232600180080824,,Neutral,Uncertain,,Neutral,0.31892861851184184,,0.2728287001527943,0.65877,,1.1455814035999798,,0.9021757017999898,,Neutral,,Neutral,,0.1013346416011561,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.4572,0.1909,-22.1174,-7.00222762676875,0.8187826613508747,Pathogenic,0.8908,pathogenic,-4.172,available,https://doi.org/10.1101/2022.10.22.513328 +Y103V,NP_000537:p.Tyr103Val,,,,,saturation_mutlist,,,,,,,,0.48457,0.7347898769378662,,0.7375879671301595,,0.6110789835650797,,Neutral,Neutral,,Neutral,0.3149334188654965,,0.2818637204545337,0.1007,,0.48227068030331594,,0.29148534015165795,,Neutral,,Neutral,,0.08643928751822454,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.4355,0.1909,-22.1174,-5.74202349396744,0.5135225637042313,Uncertain,0.7661,pathogenic,-4.099,available,https://doi.org/10.1101/2022.10.22.513328 +Y103W,NP_000537:p.Tyr103Trp,,,,,saturation_mutlist,,,,,,,,0.57981,0.16924351692199704,,0.20345324325420633,,0.3916316216271032,,Neutral,Neutral,,Neutral,0.17922288352999136,,0.20770406087453414,0.29871,,0.0010499718674688713,,0.14987998593373442,,Neutral,,Neutral,,0.10220074328887302,49.328,4.914,57.22,10.125,,False,49.328,,uncertain,,,,False,57.22,,uncertain,,,damaging,,-0.2836,0.1909,-8.8296,-3.38861835976956,0.0610032583010982,Benign,0.2683,benign,-3.79,available,https://doi.org/10.1101/2022.10.22.513328 +Q104A,NP_000537:p.Gln104Ala,,,,,saturation_mutlist,,,,,,,,0.46718,0.06879212617874143,,0.1850018549199587,,0.32609092745997936,,Neutral,Neutral,,Neutral,0.11579455915265982,,0.16766421228594122,0.41094,,0.4816477507945783,,0.44629387539728915,,Neutral,,Neutral,,0.5024365063042591,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.0798,1.2981,-2.5228,-1.13893667816556,1.4532343198023712e-15,Benign,0.0982,benign,-2.862,available,https://doi.org/10.1101/2022.10.22.513328 +Q104C,NP_000537:p.Gln104Cys,,,,,saturation_mutlist,,,,,,,,0.46324,-0.15904717206954955,,0.715776259918624,,0.589508129959312,,Neutral,Neutral,,Neutral,0.08263012443750593,,0.024390643199895173,0.21985,,0.9220514200279143,,0.5709507100139571,,Neutral,,Neutral,,0.2913274898311224,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.1582,1.2981,-8.8264,-1.1898182266111,1.02902400011064e-08,Benign,0.1754,benign,-3.13,available,https://doi.org/10.1101/2022.10.22.513328 +Q104D,NP_000537:p.Gln104Asp,,,,,saturation_mutlist,,,,,,,,0.38586,0.2820245945453644,,0.4196800252908508,,0.4027700126454254,,Neutral,Neutral,,Neutral,0.16832966873656668,,0.31915020103761615,0.37087,,0.6227819781865779,,0.4968259890932889,,Neutral,,Neutral,,0.7291597776082255,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.2663,1.2981,-22.1143,-3.29818501640832,2.149665718541949e-09,Benign,0.1777,benign,-3.084,available,https://doi.org/10.1101/2022.10.22.513328 +Q104E,NP_000537:p.Gln104Glu,,,,,saturation_mutlist,,,,,,,,-0.23061,0.07451021671295166,,0.1069243938721026,,-0.0618428030639487,,Neutral,Neutral,,Neutral,0.15511648169838768,,0.22639533751089114,0.08638,,0.2932949601909996,,0.1898374800954998,,Neutral,,Neutral,,0.5805913751624182,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.1849,1.2981,-22.1143,-2.96345143409047,1.233183880716386e-13,Benign,0.0752,benign,-2.97,available,https://doi.org/10.1101/2022.10.22.513328 +Q104F,NP_000537:p.Gln104Phe,,,,,saturation_mutlist,,,,,,,,-0.178,0.13928780555725095,,-0.40678946889456524,,-0.2923947344472826,,Neutral,Neutral,,Neutral,0.12083033501284228,,0.15040606262710046,0.07496,,-0.3657494407946804,,-0.1453947203973402,,Neutral,,Neutral,,0.018467124449024177,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.234,1.2981,-22.1143,-3.9104237502095,2.8961804074825645e-06,Benign,0.3302,benign,-3.411,available,https://doi.org/10.1101/2022.10.22.513328 +Q104G,NP_000537:p.Gln104Gly,,,,,saturation_mutlist,,,,,,,,0.70189,0.41001366257667543,,1.1029962368776465,,0.9024431184388233,,Neutral,Neutral,,Neutral,0.1812762928687836,,0.31816234080363187,0.1724,,1.2983572957562608,,0.7353786478781303,,Neutral,,Neutral,,0.582335868556902,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.1826,1.2981,-8.8264,-2.24427287698304,5.8638200738131e-13,Benign,0.1249,benign,-3.024,available,https://doi.org/10.1101/2022.10.22.513328 +Q104H,NP_000537:p.Gln104His,"hg19,17:g.7579375C>A, hg19,17:g.7676057C>A, hg38,17:g.7676057C>G",,,0.336,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.34053,-0.09294006109237671,-0.3249433333333333,-0.2958844732114631,0.0077933333333333465,0.022322763394268447,Neutral,Neutral,Neutral,Neutral,Neutral,0.1089504022555326,0.39627882451066637,0.07624919145920284,0.36222,0.18752666666666665,-0.12403942576010109,0.2748733333333333,0.11909028711994946,Neutral,Neutral,Neutral,Neutral,0.21437765746976106,0.31051308216371537,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.0948,1.2981,-5.2416,-0.346936379405604,2.9435802993527174e-11,Benign,0.0754,benign,-2.908,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q104I,NP_000537:p.Gln104Ile,,,,,saturation_mutlist,,,,,,,,0.06419,0.12213652014732361,,-0.32068335087775474,,-0.12824667543887736,,Neutral,Neutral,,Neutral,0.14754162425609404,,0.16007936385342883,0.27683,,-0.2754722494175618,,0.0006788752912190998,,Neutral,,Neutral,,0.07181059880961815,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.2154,1.2981,-22.1143,-4.30103022239613,8.856720545569785e-06,Benign,0.2682,benign,-3.335,available,https://doi.org/10.1101/2022.10.22.513328 +Q104K,NP_000537:p.Gln104Lys,,,,,saturation_mutlist,,,,,,,,-0.09053,0.2500878942012787,,0.03105063258610169,,-0.029739683706949155,,Neutral,Neutral,,Neutral,0.12113457338670318,,0.1553462436799088,-0.04838,,0.2793953951576622,,0.1155076975788311,,Neutral,,Neutral,,0.5275946006719426,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.213,1.2981,-22.1143,-4.08621299998927,1.372387526379108e-07,Benign,0.0865,benign,-3.029,available,https://doi.org/10.1101/2022.10.22.513328 +Q104L,NP_000537:p.Gln104Leu,"hg19,17:g.7579376T>A, hg38,17:g.7676058T>A",,,0.520,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",945802,Conflicting classifications of pathogenicity,1,,,,,-0.50451,0.32491241812705995,-0.4303866666666667,-0.5125879803076111,-0.46744833333333335,-0.5085489901538056,Neutral,Neutral,Neutral,Neutral,Neutral,0.13694432223186206,0.30837050975877844,0.15513530446802118,-0.03489,-0.28492333333333336,-0.5940081503918689,-0.15990666666666667,-0.31444907519593446,Neutral,Neutral,Neutral,Neutral,0.5293805457534515,0.0886739003274217,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.1309,1.2981,-8.8264,-3.67544421069349,2.3896251726472592e-08,Benign,0.097,benign,-3.047,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q104M,NP_000537:p.Gln104Met,,,,,saturation_mutlist,,,,,,,,-0.35873,0.2677972006797791,,-0.1359805193581953,,-0.24735525967909766,,Neutral,Neutral,,Neutral,0.08599749404568674,,0.09688715375186574,-0.26277,,-0.1967535066331251,,-0.22976175331656257,,Neutral,,Neutral,,0.041961538956304285,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.1697,1.2981,-22.1143,-2.86698909392207,8.251818294172312e-09,Benign,0.2587,benign,-3.149,available,https://doi.org/10.1101/2022.10.22.513328 +Q104N,NP_000537:p.Gln104Asn,,,,,saturation_mutlist,,,,,,,,0.28186,0.237678644657135,,0.19029328505765183,,0.23607664252882593,,Neutral,Neutral,,Neutral,0.12829620105570042,,0.16391119954125644,0.27825,,0.39520314739374024,,0.3367265736968701,,Neutral,,Neutral,,0.4340370336464738,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.1955,1.2981,-22.1143,-3.22168110342398,1.291236349428933e-09,Benign,0.1417,benign,-3.08,available,https://doi.org/10.1101/2022.10.22.513328 +Q104P,NP_000537:p.Gln104Pro,,,,,saturation_mutlist,,,,,,,,-0.29555,0.045996048450469985,,2.1095417858430414,,0.9069958929215207,,Uncertain,Neutral,,Neutral,0.3128611274358306,,1.0884537548990398,0.50566,,1.5507148208112955,,1.0281874104056477,,Neutral,,Neutral,,0.6839625796970469,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.2429,1.2981,-0.4602,0.499057518359793,2.739106371421924e-22,Benign,0.0597,benign,-2.806,available,https://doi.org/10.1101/2022.10.22.513328 +Q104R,NP_000537:p.Gln104Arg,"hg19,17:g.7676058T>C",,,,"cBioPortal,saturation_mutlist",,,,,,,,0.08771,0.2833669137954712,,-0.2969968388568505,,-0.10464341942842526,,Neutral,Neutral,,Neutral,0.10860136167876945,,0.04536617301010966,0.02455,,-0.1598394488338876,,-0.0676447244169438,,Neutral,,Neutral,,0.25538071068519863,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.1386,1.2981,-7.8265,-0.783108861350225,4.24964411085832e-09,Benign,0.0671,benign,-3.03,available,https://doi.org/10.1101/2022.10.22.513328 +Q104S,NP_000537:p.Gln104Ser,,,,,saturation_mutlist,,,,,,,,0.27521,-0.09556612491607665,,0.3824509710595761,,0.32883048552978805,,Neutral,Neutral,,Neutral,0.13130230408204144,,0.3065459916969476,-0.15595,,0.5992540894481493,,0.22165204472407463,,Neutral,,Neutral,,0.5695986622036502,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.1253,1.2981,-7.8265,-0.952433831807965,1.632005229133553e-13,Benign,0.111,benign,-2.896,available,https://doi.org/10.1101/2022.10.22.513328 +Q104T,NP_000537:p.Gln104Thr,,,,,saturation_mutlist,,,,,,,,0.5004,-0.09654404640197754,,0.15895408905594785,,0.3296770445279739,,Neutral,Neutral,,Neutral,0.19453170403833028,,0.1258333219002014,0.37377,,0.35107447831345256,,0.3624222391567263,,Neutral,,Neutral,,0.4069022621719692,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.2081,1.2981,-22.1143,-2.46000719912689,2.474330420377527e-09,Benign,0.1203,benign,-3.01,available,https://doi.org/10.1101/2022.10.22.513328 +Q104V,NP_000537:p.Gln104Val,,,,,saturation_mutlist,,,,,,,,0.41851,-0.015483708381652828,,-0.21381254488716525,,0.10234872755641737,,Neutral,Neutral,,Neutral,0.11694658667134271,,0.12383260424098032,0.35932,,-0.1115860263568359,,0.12386698682158204,,Neutral,,Neutral,,0.08642082070171409,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,uncertain,,-0.1426,1.2981,-7.8265,-2.664640281264,4.951669274902942e-12,Benign,0.1735,benign,-3.066,available,https://doi.org/10.1101/2022.10.22.513328 +Q104W,NP_000537:p.Gln104Trp,,,,,saturation_mutlist,,,,,,,,0.18052,0.21614434123039244,,-0.7615046321137112,,-0.2904923160568556,,Neutral,Neutral,,Neutral,0.11207040891760339,,0.11375454517772562,0.36287,,-0.7310940839425916,,-0.18411204197129577,,Neutral,,Neutral,,0.05154575125000322,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.2334,1.2981,-22.1143,-3.9104237502095,2.6223556719387905e-05,Benign,0.2238,benign,-3.606,available,https://doi.org/10.1101/2022.10.22.513328 +Q104Y,NP_000537:p.Gln104Tyr,,,,,saturation_mutlist,,,,,,,,-0.03862,0.11057836771011352,,-0.3595837692834014,,-0.1991018846417007,,Neutral,Neutral,,Neutral,0.14125552765909466,,0.10260525057981296,0.02278,,-0.291608201439496,,-0.134414100719748,,Neutral,,Neutral,,0.07793536596232878,63.127,10.858,51.585,11.472,,False,63.127,,neutral,neutral,neutral,,False,51.585,,neutral,neutral,neutral,neutral,,-0.2363,1.2981,-22.1143,-3.9104237502095,4.096854579108191e-07,Benign,0.1931,benign,-3.271,available,https://doi.org/10.1101/2022.10.22.513328 +G105A,NP_000537:p.Gly105Ala,"hg19,17:g.7579372_7579373delinsTG, hg19,17:g.7579373C>G, hg19,17:g.7676055C>G, hg38,17:g.7676054_7676055delinsTG, hg38,17:g.7676055C>G",,,0.905,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2035647, 822977","Uncertain significance, Uncertain significance","1, 1",,,,,3.00287,1.734505524635315,2.0630366666666666,2.2132017768137326,2.5329533333333334,2.6080358884068664,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.3317361930666816,1.1949729662028157,0.2743677949588362,2.86047,2.47007,1.6464255819793747,2.66527,2.2534477909896875,Uncertain,Uncertain,Uncertain,Uncertain,1.422484123660671,0.8774863967010358,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.3766,0.0719,-22.1395,-6.74333955675446,0.8385150035108706,Pathogenic,0.91,pathogenic,-4.057,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105C,NP_000537:p.Gly105Cys,"hg19,17:g.7579374C>A, hg19,17:g.7676056C>A, hg38,17:g.7676056C>A",,,0.942,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,4.6122,1.2079216074943542,5.293423333333333,3.2760198767484,4.952811666666666,3.9441099383741998,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.3220905768303376,1.2652186867714037,0.32209395975356186,3.9387,3.6466,2.0592382593659386,3.79265,2.998969129682969,Destabilizing,Uncertain,Destabilizing,Uncertain,1.529336424553691,1.1348880296466164,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4363,0.0719,-22.1395,-6.74333955675446,0.5968165061362787,Uncertain,0.9886,pathogenic,-4.165,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105D,NP_000537:p.Gly105Asp,"hg19,17:g.7579373C>T, hg19,17:g.7676055C>T, hg38,17:g.7676055C>T",,0.0,0.884,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141114,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,5.85026,2.129411654472351,1.7835600000000003,3.185611719888357,3.81691,4.517935859944179,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.41908200621375946,1.4133488491050843,1.197832753265317,4.42539,2.82018,1.5382718982897459,3.6227850000000004,2.981830949144873,Uncertain,Uncertain,Destabilizing,Uncertain,3.0402563944838596,1.0722198559045855,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4368,0.0719,-22.1395,-7.12293207473506,0.5717155087405259,Uncertain,0.9794,pathogenic,-3.926,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105E,NP_000537:p.Gly105Glu,,,,,saturation_mutlist,,,,,,,,5.95225,2.2666211223602293,,3.960181192181961,,4.95621559609098,,Destabilizing,Destabilizing,,Destabilizing,0.3480824980453287,,1.4374238402187947,5.0502,,1.8859727033670195,,3.46808635168351,,Uncertain,,Destabilizing,,1.3602882247197865,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4361,0.0719,-22.1395,-7.12293207473506,0.870829128776961,Pathogenic,0.9905,pathogenic,-4.108,available,https://doi.org/10.1101/2022.10.22.513328 +G105F,NP_000537:p.Gly105Phe,"hg19,17:g.7579373_7579374delinsAA",,,,"cBioPortal,saturation_mutlist",,,,,,,,5.33819,1.571491265296936,5.104873333333333,3.2513487941141093,5.2215316666666665,4.294769397057054,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.24010859744533103,1.0001729677855171,1.353465231567047,6.60629,8.078003333333333,1.3569372956239036,7.342146666666666,3.981613647811952,Destabilizing,Uncertain,Destabilizing,Destabilizing,3.837220908281872,1.4004143360042527,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4744,0.0719,-22.1395,-7.12293207473506,0.8686935710805768,Pathogenic,0.9956,pathogenic,-4.443,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105H,NP_000537:p.Gly105His,,,,,saturation_mutlist,,,,,,,,8.35074,1.9434147930145265,,3.149918942189037,,5.750329471094519,,Destabilizing,Uncertain,,Destabilizing,0.31800479790437364,,1.4166141291647212,7.45817,,1.3911187348831762,,4.424644367441588,,Uncertain,,Destabilizing,,1.3015778693506657,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4491,0.0719,-22.1395,-7.12293207473506,0.7725890143480263,Pathogenic,0.9965,pathogenic,-4.064,available,https://doi.org/10.1101/2022.10.22.513328 +G105I,NP_000537:p.Gly105Ile,,,,,saturation_mutlist,,,,,,,,7.25108,1.9632396030426025,,4.938274985981554,,6.094677492990777,,Destabilizing,Uncertain,,Destabilizing,0.3147380398518429,,1.0070770661624975,7.34188,,2.607501580927105,,4.974690790463552,,Uncertain,,Destabilizing,,1.4288235147153872,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.5201,0.0719,-22.1395,-7.12293207473506,0.8675470810174329,Pathogenic,0.995,pathogenic,-4.558,available,https://doi.org/10.1101/2022.10.22.513328 +G105K,NP_000537:p.Gly105Lys,,,,,saturation_mutlist,,,,,,,,4.79272,2.095581398010254,,3.87462693303369,,4.333673466516845,,Destabilizing,Destabilizing,,Destabilizing,0.3805935848332154,,1.8620210592074877,4.82188,,1.8701112222794583,,3.3459956111397293,,Uncertain,,Destabilizing,,1.5344490577913619,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4691,0.0719,-22.1395,-7.12293207473506,0.8626008099471941,Pathogenic,0.9964,pathogenic,-4.225,available,https://doi.org/10.1101/2022.10.22.513328 +G105L,NP_000537:p.Gly105Leu,,,,,saturation_mutlist,,,,,,,,5.8023,1.710879888534546,,3.5708235586311345,,4.686561779315567,,Destabilizing,Uncertain,,Destabilizing,0.2716401587854906,,1.1998084349340583,5.39898,,1.5226377579429842,,3.460808878971492,,Uncertain,,Destabilizing,,1.3462513459105656,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4883,0.0719,-22.1395,-7.12293207473506,0.8704061861275223,Pathogenic,0.9936,pathogenic,-4.322,available,https://doi.org/10.1101/2022.10.22.513328 +G105M,NP_000537:p.Gly105Met,,,,,saturation_mutlist,,,,,,,,4.63257,1.7080691003799437,,3.4265698761686187,,4.029569938084309,,Destabilizing,Uncertain,,Destabilizing,0.2671707247879226,,1.1056930414017148,4.52077,,1.5562685679158994,,3.0385192839579496,,Uncertain,,Destabilizing,,1.3334902390776473,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4265,0.0719,-22.1395,-7.12293207473506,0.8279835756097328,Pathogenic,0.9967,pathogenic,-4.442,available,https://doi.org/10.1101/2022.10.22.513328 +G105N,NP_000537:p.Gly105Asn,,,,,saturation_mutlist,,,,,,,,5.56595,1.92625230550766,,2.55940260447028,,4.06267630223514,,Uncertain,Uncertain,,Destabilizing,0.4552019375866978,,0.8869168096718588,4.74097,,1.2718538838190305,,3.006411941909515,,Uncertain,,Destabilizing,,1.2196072717309774,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4371,0.0719,-22.1395,-7.12293207473506,0.2037088493655584,Benign,0.9872,pathogenic,-3.879,available,https://doi.org/10.1101/2022.10.22.513328 +G105P,NP_000537:p.Gly105Pro,,,,,saturation_mutlist,,,,,,,,9.62448,2.4830648708343506,,8.068828490500303,,8.846654245250152,,Destabilizing,Destabilizing,,Destabilizing,0.22647103505814373,,0.6327090043205535,5.88173,,7.078427257117994,,6.4800786285589975,,Destabilizing,,Destabilizing,,1.2411662602682492,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.5342,0.0719,-22.1395,-7.12293207473506,0.8175572230640045,Pathogenic,0.994,pathogenic,-4.11,available,https://doi.org/10.1101/2022.10.22.513328 +G105Q,NP_000537:p.Gly105Gln,,,,,saturation_mutlist,,,,,,,,5.747,1.999351477622986,,3.6679405244714354,,4.707470262235717,,Destabilizing,Uncertain,,Destabilizing,0.33367660694651163,,1.1909007480289995,5.20219,,1.983840124371129,,3.5930150621855645,,Uncertain,,Destabilizing,,1.3516389279052958,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.44,0.0719,-22.1395,-7.12293207473506,0.7489744876253293,Pathogenic,0.9956,pathogenic,-4.222,available,https://doi.org/10.1101/2022.10.22.513328 +G105R,NP_000537:p.Gly105Arg,"hg19,17:g.7579374C>G, hg19,17:g.7676056C>G, hg38,17:g.7676056C>G",,,0.918,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406574,Pathogenic/Likely pathogenic,2,,,,,5.00632,2.14373122215271,5.10034,3.3703840899646402,5.05333,4.18835204498232,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.3546916435938958,0.6137794301430007,1.7118641880793435,4.94036,5.441836666666667,1.6503566116287673,5.191098333333334,3.295358305814384,Destabilizing,Uncertain,Destabilizing,Destabilizing,3.4336541706111805,1.465716688336945,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4531,0.0719,-22.1395,-7.12293207473506,0.8015435684123399,Pathogenic,0.9962,pathogenic,-4.185,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105S,NP_000537:p.Gly105Ser,"hg19,17:g.7579374C>T, hg19,17:g.7676056C>T, hg38,17:g.7676056C>T",,,0.883,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428884,Pathogenic/Likely pathogenic,2,,,,,4.08137,1.7437126326560974,1.7897999999999998,2.7652684399455496,2.9355849999999997,3.4233192199727744,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,0.590219372884491,1.2928300988915753,0.4324667878599523,3.66973,1.6696133333333334,1.8428376612152266,2.669671666666667,2.756283830607613,Uncertain,Uncertain,Uncertain,Uncertain,1.826032871579504,0.9906718110245077,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.3044,0.0719,-6.8517,-4.36994679958428,0.2968200683582394,Benign,0.9562,pathogenic,-3.686,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105T,NP_000537:p.Gly105Thr,,,,,saturation_mutlist,,,,,,,,6.84243,1.836410527229309,,3.827383695424688,,5.334906847712344,,Destabilizing,Uncertain,,Destabilizing,0.5739860524231015,,0.5857688202869133,5.84208,,2.460143033110613,,4.151111516555306,,Uncertain,,Destabilizing,,1.140804978882278,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4594,0.0719,-22.1395,-6.74333955675446,0.756637955227241,Pathogenic,0.9819,pathogenic,-4.068,available,https://doi.org/10.1101/2022.10.22.513328 +G105V,NP_000537:p.Gly105Val,"hg19,17:g.7579372_7579373delinsAA, hg19,17:g.7579373C>A, hg19,17:g.7676055C>A, hg38,17:g.7676055C>A",,,0.919,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634708,Conflicting classifications of pathogenicity,1,,,,,7.01647,1.85747465133667,8.643196666666666,4.348439733056206,7.829833333333333,5.6824548665281025,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.2902890717261355,3.707487496947525,0.6829376710775186,6.48524,4.068933333333333,2.588070195482747,5.2770866666666665,4.536655097741374,Destabilizing,Uncertain,Destabilizing,Destabilizing,2.7819034179296898,1.285678792739813,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4633,0.0719,-22.1395,-7.12293207473506,0.8433656754383163,Pathogenic,0.9868,pathogenic,-4.33,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105W,NP_000537:p.Gly105Trp,,,,,saturation_mutlist,,,,,,,,6.9778,1.7647092199325563,,3.302751614601174,,5.140275807300587,,Destabilizing,Uncertain,,Destabilizing,0.24833473830157157,,1.8836747014738864,8.28567,,1.1290754335519047,,4.707372716775952,,Uncertain,,Destabilizing,,1.421070175852371,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4742,0.0719,-22.1395,-7.12293207473506,0.866689999244427,Pathogenic,0.9936,pathogenic,-4.485,available,https://doi.org/10.1101/2022.10.22.513328 +G105Y,NP_000537:p.Gly105Tyr,,,,,saturation_mutlist,,,,,,,,5.98813,1.8210756826400756,,3.5902871891996484,,4.789208594599824,,Destabilizing,Uncertain,,Destabilizing,0.22754644974863728,,1.4610781371498598,6.62017,,1.5050982180204153,,4.062634109010208,,Uncertain,,Destabilizing,,1.334069782334528,35.526,9.454,41.095,22.42,,True,35.526,,neutral,neutral,neutral,,True,41.095,,neutral,neutral,neutral,neutral,,-0.4748,0.0719,-22.1395,-7.12293207473506,0.8058493594920272,Pathogenic,0.9927,pathogenic,-4.387,available,https://doi.org/10.1101/2022.10.22.513328 +S106A,NP_000537:p.Ser106Ala,,,,,saturation_mutlist,,,,,,,,-0.00292,-0.004417393207550052,,0.00896238689199653,,0.003021193445998265,,Neutral,Neutral,,Neutral,0.04406445252743345,,0.22231640295208363,-0.45182,,0.13775662463190527,,-0.15703168768404735,,Neutral,,Neutral,,0.10524727005872807,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,uncertain,,0.0065,2.1928,-5.5329,-0.319371549765048,1.364787077859729e-07,Benign,0.0748,benign,-2.872,available,https://doi.org/10.1101/2022.10.22.513328 +S106C,NP_000537:p.Ser106Cys,,,,,saturation_mutlist,,,,,,,,-0.34981,0.046888473033905004,,0.6022731956030306,,0.1262315978015153,,Neutral,Neutral,,Neutral,0.08172096966602677,,0.30368158821535884,-0.08406,,0.7258493390044914,,0.3208946695022457,,Neutral,,Neutral,,0.18656725298591026,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.0528,2.1928,-7.2699,-0.267167543724268,2.088058014168096e-05,Benign,0.074,benign,-3.245,available,https://doi.org/10.1101/2022.10.22.513328 +S106D,NP_000537:p.Ser106Asp,,,,,saturation_mutlist,,,,,,,,-0.05736,0.4280247938632965,,-0.05223857718149893,,-0.054799288590749465,,Neutral,Neutral,,Neutral,0.06464022136577917,,0.1599892268722576,0.045,,0.07301349488109976,,0.05900674744054988,,Neutral,,Neutral,,0.5031336731524207,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.0863,2.1928,-4.3954,-0.0350143755602524,2.2175866141669507e-11,Benign,0.0825,benign,-2.882,available,https://doi.org/10.1101/2022.10.22.513328 +S106E,NP_000537:p.Ser106Glu,,,,,saturation_mutlist,,,,,,,,-0.60165,0.17245596289634701,,-0.06409527615809836,,-0.3328726380790492,,Neutral,Neutral,,Neutral,0.05197738481504369,,0.2767324044928944,-0.41228,,0.2213997280062957,,-0.09544013599685214,,Neutral,,Neutral,,0.34815022557711905,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.0521,2.1928,-2.948,-0.193014108031156,6.206714105322146e-12,Benign,0.1379,benign,-2.916,available,https://doi.org/10.1101/2022.10.22.513328 +S106F,NP_000537:p.Ser106Phe,,,,,saturation_mutlist,,,,,,,,-0.26926,0.558195424079895,,-0.5005489166658881,,-0.38490445833294407,,Neutral,Neutral,,Neutral,0.10080562049484303,,0.10005412339364984,-0.77381,,-0.1609134636742308,,-0.4673617318371154,,Neutral,,Neutral,,0.08144222499670487,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.1563,2.1928,-22.1426,-2.79212075860017,0.0004047174237045,Benign,0.2,benign,-3.338,available,https://doi.org/10.1101/2022.10.22.513328 +S106G,NP_000537:p.Ser106Gly,,,,,saturation_mutlist,,,,,,,,0.35753,0.49711785674095155,,0.6858558715389935,,0.5216929357694968,,Neutral,Neutral,,Neutral,0.056270079224486264,,0.19132444982605465,-0.0045,,0.5148271653768566,,0.2551635826884283,,Neutral,,Neutral,,0.397261680435943,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,uncertain,,-0.0094,2.1928,-6.8548,-2.07778115524425,0.0001150350450643,Benign,0.0688,benign,-3.065,available,https://doi.org/10.1101/2022.10.22.513328 +S106H,NP_000537:p.Ser106His,,,,,saturation_mutlist,,,,,,,,0.08138,0.19239281892776489,,-0.43908801794772784,,-0.17885400897386391,,Neutral,Neutral,,Neutral,0.08276788000254412,,0.12439952533505735,-0.16558,,-0.28709456203660977,,-0.2263372810183049,,Neutral,,Neutral,,0.14430488578873252,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.1575,2.1928,-22.1426,-1.9537294209898,3.855441706675246e-07,Benign,0.1117,benign,-3.127,available,https://doi.org/10.1101/2022.10.22.513328 +S106I,NP_000537:p.Ser106Ile,"hg19,17:g.7579370C>A, hg38,17:g.7676052C>A",,,0.450,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",629791,Conflicting classifications of pathogenicity,1,,,,,-0.5484,0.17595052480697632,-0.3815199999999999,-0.2578929491965372,-0.46495999999999993,-0.4031464745982686,Neutral,Neutral,Neutral,Neutral,Neutral,0.14715749014563873,0.5376516681520357,0.3869638658133121,-0.3259,-0.37199333333333334,0.42067991149044026,-0.3489466666666667,0.04738995574522012,Neutral,Neutral,Neutral,Neutral,0.5013811134811078,0.4330210248696186,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.1594,2.1928,-22.1426,-2.28545542961298,0.000257745181244,Benign,0.0984,benign,-3.34,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S106K,NP_000537:p.Ser106Lys,,,,,saturation_mutlist,,,,,,,,-0.84523,-0.14173763275146484,,-0.0500980163988653,,-0.44766400819943264,,Neutral,Neutral,,Neutral,0.08680122445932932,,0.16565705392743577,-0.99402,,-0.022216089677190538,,-0.5081180448385952,,Neutral,,Neutral,,0.19876242057978102,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.0909,2.1928,-7.2699,-0.641565901758129,4.453103796561074e-07,Benign,0.1643,benign,-3.18,available,https://doi.org/10.1101/2022.10.22.513328 +S106L,NP_000537:p.Ser106Leu,,,,,saturation_mutlist,,,,,,,,-0.76196,0.31068201541900636,,-0.63880883528142,,-0.7003844176407099,,Neutral,Neutral,,Neutral,0.12156523805462091,,0.1959787744459219,-0.8027,,-0.33266135606846864,,-0.5676806780342343,,Neutral,,Neutral,,0.10771462399955273,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.0798,2.1928,-7.2699,-1.41211486901111,2.3304879131265587e-07,Benign,0.1206,benign,-3.104,available,https://doi.org/10.1101/2022.10.22.513328 +S106M,NP_000537:p.Ser106Met,,,,,saturation_mutlist,,,,,,,,-1.02767,0.36438234329223634,,-0.3787554664664729,,-0.7032127332332365,,Neutral,Neutral,,Neutral,0.10470081595139444,,0.14402303169237793,-1.01936,,-0.056796398606870524,,-0.5380781993034353,,Neutral,,Neutral,,0.11820778918529935,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.1267,2.1928,-22.1426,-2.73274032969055,0.0127804922394187,Benign,0.1661,benign,-3.484,available,https://doi.org/10.1101/2022.10.22.513328 +S106N,NP_000537:p.Ser106Asn,"hg19,17:g.7579370C>T",,,0.340,"cBioPortal,saturation_mutlist",,,,,,,,-0.23912,0.2669074034690857,,-0.12639055013515885,,-0.18275527506757944,,Neutral,Neutral,,Neutral,0.060724862532636655,,0.1327581250933432,-0.14323,,-0.19773446808340242,,-0.1704822340417012,,Neutral,,Neutral,,0.36642261744584204,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.01,2.1928,-4.3954,-0.0674115432093849,3.2469969733363184e-11,Benign,0.0567,benign,-2.846,available,https://doi.org/10.1101/2022.10.22.513328 +S106P,NP_000537:p.Ser106Pro,,,,,saturation_mutlist,,,,,,,,-1.32341,-0.19784891843795777,,2.904690305565166,,0.790640152782583,,Uncertain,Neutral,,Neutral,0.19417751764592212,,0.8375412805438646,-1.10177,,2.976706602680475,,0.9374683013402375,,Uncertain,,Neutral,,0.6235317685339761,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.1227,2.1928,-0.7834,-1.09494593675366,9.454257361097516e-09,Benign,0.1161,benign,-2.94,available,https://doi.org/10.1101/2022.10.22.513328 +S106Q,NP_000537:p.Ser106Gln,,,,,saturation_mutlist,,,,,,,,-0.52709,0.007653007507324211,,-0.011833961447104894,,-0.26946198072355243,,Neutral,Neutral,,Neutral,0.04447871160942667,,0.2134264821874185,-0.5781,,0.17979743947888663,,-0.19915128026055667,,Neutral,,Neutral,,0.1821088289127592,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.0443,2.1928,-7.2699,-1.23191517597685,1.3578309439003664e-07,Benign,0.1524,benign,-3.021,available,https://doi.org/10.1101/2022.10.22.513328 +S106R,NP_000537:p.Ser106Arg,"hg19,17:g.7579369G>C, hg19,17:g.7676051G>C, hg38,17:g.7676051G>C",,,0.635,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",492752,Pathogenic,3,,,,,-0.62831,0.01003895759582519,-0.43129333333333336,-0.31908052043052804,-0.5298016666666667,-0.47369526021526404,Neutral,Neutral,Neutral,Neutral,Neutral,0.09859074894651029,0.13094325089730877,0.16856285992479228,-0.9864,-0.56587,-0.24399022828737124,-0.776135,-0.6151951141436857,Neutral,Neutral,Neutral,Neutral,0.3383871975513652,0.10564589739581291,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.1721,2.1928,-22.1426,-2.35626639900643,0.0002762297048018,Benign,0.1535,benign,-3.241,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S106T,NP_000537:p.Ser106Thr,,,,,saturation_mutlist,,,,,,,,0.09645,0.25783825039863584,,0.09741273957309919,,0.09693136978654959,,Neutral,Neutral,,Neutral,0.050734072275464684,,0.305647703741856,0.0802,,0.3291490507358656,,0.2046745253679328,,Neutral,,Neutral,,0.21578064177870646,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,neutral,neutral,potentially_damaging,P,True,75.315,0.198,neutral,neutral,potentially_damaging,neutral,,0.0217,2.1928,-4.3954,-0.315813291316464,1.1327288542254062e-09,Benign,0.066,benign,-2.841,available,https://doi.org/10.1101/2022.10.22.513328 +S106V,NP_000537:p.Ser106Val,,,,,saturation_mutlist,,,,,,,,-0.04815,0.25206727504730225,,-0.1262877897924153,,-0.08721889489620765,,Neutral,Neutral,,Neutral,0.12788624505671234,,0.4081003621203368,-0.01544,,0.42002374459764197,,0.20229187229882098,,Neutral,,Neutral,,0.39931489295972633,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.054,2.1928,-6.5329,-0.507336369016706,1.513084760105849e-07,Benign,0.1084,benign,-3.117,available,https://doi.org/10.1101/2022.10.22.513328 +S106W,NP_000537:p.Ser106Trp,,,,,saturation_mutlist,,,,,,,,-0.34291,0.5035673248767852,,-0.827857952587831,,-0.5853839762939155,,Neutral,Neutral,,Neutral,0.09847074181936757,,0.18138461329435357,-0.62084,,-0.3838871676293037,,-0.5023635838146518,,Neutral,,Neutral,,0.12863928210883097,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,damaging,neutral,potentially_damaging,P,True,75.315,0.198,damaging,neutral,potentially_damaging,neutral,,-0.166,2.1928,-22.1426,-3.04852341281063,0.0372724252396779,Benign,0.2967,benign,-3.706,available,https://doi.org/10.1101/2022.10.22.513328 +S106Y,NP_000537:p.Ser106Tyr,,,,,saturation_mutlist,,,,,,,,-0.13763,0.4484206938743591,,-0.4505300602096429,,-0.2940800301048215,,Neutral,Neutral,,Neutral,0.11694178988448799,,0.09202847088258474,-0.66942,,-0.08257095095484183,,-0.3759954754774209,,Neutral,,Neutral,,0.06762238655424785,88.432,6.404,75.315,18.547,P,True,88.432,-0.108,uncertain,neutral,potentially_damaging,P,True,75.315,0.198,uncertain,neutral,potentially_damaging,neutral,,-0.1611,2.1928,-22.1426,-2.77670836141573,0.0004847956463587,Benign,0.1548,benign,-3.306,available,https://doi.org/10.1101/2022.10.22.513328 +Y107A,NP_000537:p.Tyr107Ala,,,,,saturation_mutlist,,,,,,,,2.04009,2.1160393857955935,,3.764572814284818,,2.902331407142409,,Uncertain,Destabilizing,,Uncertain,0.42510855116429164,,0.46362673163582324,-5.33731,,3.4145917915727164,,-0.961359104213642,,Uncertain,,Neutral,,0.2308009569335378,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.3389,1.2242,-22.1426,-4.87067551376095,0.5944614508237123,Uncertain,0.6824,pathogenic,-3.66,available,https://doi.org/10.1101/2022.10.22.513328 +Y107C,NP_000537:p.Tyr107Cys,"hg19,17:g.7579367T>C, hg38,17:g.7676049T>C",,,0.883,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142691,Uncertain significance,2,,,,,1.62067,1.2842501187324524,2.1417266666666666,3.7689082690284312,1.8811983333333333,2.694789134514216,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,0.4036046593759119,0.3544228802182813,0.40231466914609365,-5.51536,2.1481866666666667,3.4345775882458773,-1.6835866666666668,-1.0403912058770615,Uncertain,Uncertain,Neutral,Neutral,0.8169844121863987,0.2497189979086115,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.2299,1.2242,-6.5329,-3.04953526536538,0.0007360667947813,Benign,0.1054,benign,-3.272,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y107D,NP_000537:p.Tyr107Asp,"hg19,17:g.7579368A>C, hg19,17:g.7676050A>C, hg38,17:g.7676050A>C",,,0.893,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",641482,Conflicting classifications of pathogenicity,1,,,,,2.88449,2.4811785793304444,2.5514733333333335,4.560507390489937,2.7179816666666667,3.722498695244968,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,0.25092115216210875,0.3785800243306852,0.47317047017603797,-2.44702,3.53492,4.423491544451951,0.5439499999999999,0.9882357722259756,Uncertain,Uncertain,Neutral,Neutral,0.6878856303679172,0.252601246073882,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.2853,1.2242,-8.8547,-5.59159700627411,0.3691797235792885,Uncertain,0.8344,pathogenic,-3.82,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y107E,NP_000537:p.Tyr107Glu,,,,,saturation_mutlist,,,,,,,,2.35376,2.6563869380950926,,4.487728876824348,,3.420744438412174,,Uncertain,Destabilizing,,Destabilizing,0.29566321666330764,,0.4410508466698323,-2.01955,,4.1923151048002785,,1.0863825524001391,,Uncertain,,Neutral,,0.12027207353848836,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.3818,1.2242,-22.1426,-5.59159700627411,0.8088041795014813,Pathogenic,0.8884,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328 +Y107F,NP_000537:p.Tyr107Phe,,,,,saturation_mutlist,,,,,,,,-0.49806,0.17231379985809325,,0.6401392523166483,,0.07103962615832413,,Neutral,Neutral,,Neutral,0.1520074757712162,,0.43390355868594455,0.16572,,0.7391637856141745,,0.45244189280708724,,Neutral,,Neutral,,0.6116997722629863,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,uncertain,,-0.0933,1.2242,-5.8549,-0.707884473428679,0.0002022960030985,Benign,0.0791,benign,-3.08,available,https://doi.org/10.1101/2022.10.22.513328 +Y107G,NP_000537:p.Tyr107Gly,,,,,saturation_mutlist,,,,,,,,3.00934,1.8584915113449096,,5.252693704738029,,4.131016852369014,,Destabilizing,Uncertain,,Destabilizing,0.3713358750898981,,0.3902502917474278,-5.01353,,4.849772741844297,,-0.0818786290778517,,Uncertain,,Neutral,,0.432069044864411,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.4095,1.2242,-22.1426,-6.12475295393761,0.7573131343035386,Pathogenic,0.6677,pathogenic,-3.93,available,https://doi.org/10.1101/2022.10.22.513328 +Y107H,NP_000537:p.Tyr107His,"hg19,17:g.7579368A>G, hg38,17:g.7676050A>G",0.00041422380831,8.35488362841e-05,0.569,"COSMIC,ClinVar,saturation_mutlist",140786,Benign,3,,,,,1.68887,1.2098508644104005,1.1769833333333333,2.3294889272098076,1.4329266666666667,2.009179463604904,Neutral,Uncertain,Uncertain,Neutral,Uncertain,0.23781209855637359,0.20650996058839935,0.17790037896848235,-0.50075,1.8995466666666665,2.4870574427422825,0.6993983333333332,0.9931537213711412,Neutral,Uncertain,Neutral,Neutral,0.6880799024015225,0.16366632098157524,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.1365,1.2242,-0.5695,-1.59656500473781,2.380978682489339e-07,Benign,0.1966,benign,-2.881,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y107I,NP_000537:p.Tyr107Ile,,,,,saturation_mutlist,,,,,,,,0.65831,1.8953865957260132,,2.5391903539257155,,1.5987501769628576,,Uncertain,Uncertain,,Neutral,0.5698735647792719,,0.3907799654904956,-4.63573,,2.201892434509234,,-1.216918782745383,,Uncertain,,Neutral,,0.43922814816751965,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.351,1.2242,-22.1426,-4.56681478617394,0.260375439748877,Benign,0.6974,pathogenic,-3.732,available,https://doi.org/10.1101/2022.10.22.513328 +Y107K,NP_000537:p.Tyr107Lys,,,,,saturation_mutlist,,,,,,,,1.13537,2.3026521253585814,,4.6417957754136765,,2.8885828877068382,,Uncertain,Destabilizing,,Uncertain,0.3265869109093268,,0.3569230293567413,-4.36258,,4.287152592848137,,-0.037713703575931845,,Uncertain,,Neutral,,0.1560797546942792,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.4071,1.2242,-22.1426,-6.12475295393761,0.7825363331351646,Pathogenic,0.8746,pathogenic,-3.824,available,https://doi.org/10.1101/2022.10.22.513328 +Y107L,NP_000537:p.Tyr107Leu,,,,,saturation_mutlist,,,,,,,,-0.20635,1.653635902404785,,2.287974088723017,,1.0408120443615085,,Uncertain,Uncertain,,Neutral,0.5766214288758215,,0.16854346432339912,-5.57015,,1.8052053707458835,,-1.882472314627058,,Uncertain,,Neutral,,0.4693526437457244,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.2433,1.2242,-5.5329,-2.72760035987511,4.154539960913622e-06,Benign,0.456,ambiguous,-3.141,available,https://doi.org/10.1101/2022.10.22.513328 +Y107M,NP_000537:p.Tyr107Met,,,,,saturation_mutlist,,,,,,,,-0.24584,1.5614503407478333,,2.526718088371318,,1.1404390441856591,,Uncertain,Uncertain,,Neutral,0.42176664621780546,,0.15822136396869363,-6.18417,,2.2683414143571325,,-1.9579142928214337,,Uncertain,,Neutral,,0.3965136368590701,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.2802,1.2242,-22.1426,-4.25892139404297,0.0582015325428709,Benign,0.7267,pathogenic,-3.657,available,https://doi.org/10.1101/2022.10.22.513328 +Y107N,NP_000537:p.Tyr107Asn,"hg19,17:g.7579368A>T, hg38,17:g.7676050A>T",,,0.853,"ClinVar,saturation_mutlist",406572,Uncertain significance,1,,,,,1.7031,1.9493871974945067,2.0793666666666666,3.568892918896497,1.8912333333333333,2.635996459448249,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,0.3146162696666591,0.2014869804451118,0.3186422928961358,-4.40064,2.76712,3.384527190733363,-0.8167600000000002,-0.5080564046333185,Uncertain,Uncertain,Neutral,Neutral,0.7522704296106996,0.2017641563353385,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.3321,1.2242,-22.1426,-5.28636910841999,0.3290125044520225,Uncertain,0.4591,ambiguous,-3.62,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y107P,NP_000537:p.Tyr107Pro,,,,,saturation_mutlist,,,,,,,,1.80989,2.1793527698516844,,6.0110646195061355,,3.910477309753068,,Uncertain,Destabilizing,,Destabilizing,0.28814813580532656,,0.5467615753788174,-2.90557,,5.810708842769383,,1.4525694213846916,,Uncertain,,Neutral,,0.8221786742636585,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.4631,1.2242,-22.1426,-6.12475295393761,0.5457743752717799,Uncertain,0.9417,pathogenic,-3.756,available,https://doi.org/10.1101/2022.10.22.513328 +Y107Q,NP_000537:p.Tyr107Gln,"hg38,17:g.7676048_7676050delinsTTG",,,,"COSMIC,saturation_mutlist",,,,,,,,1.74348,2.269760160446167,2.1693866666666666,3.7654777604336878,1.9564333333333332,2.754478880216844,Uncertain,Uncertain,Destabilizing,Neutral,Uncertain,0.2914140647332154,0.4427139687829554,0.33786684768133574,-3.82912,2.4498866666666665,3.512212723686938,-0.6896166666666668,-0.15845363815653113,Uncertain,Uncertain,Neutral,Neutral,0.6030457108894999,0.1849675671154176,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.3566,1.2242,-22.1426,-5.59159700627411,0.2982900482494743,Benign,0.7612,pathogenic,-3.446,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y107R,NP_000537:p.Tyr107Arg,,,,,saturation_mutlist,,,,,,,,1.51993,2.056874279975891,,3.778648674579145,,2.6492893372895727,,Uncertain,Destabilizing,,Uncertain,0.2674232554206907,,0.38863887320349566,-2.58034,,3.5002870128869454,,0.4599735064434727,,Uncertain,,Neutral,,0.26646138584112394,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.4024,1.2242,-22.1426,-6.12475295393761,0.4526033376308064,Uncertain,0.6924,pathogenic,-3.786,available,https://doi.org/10.1101/2022.10.22.513328 +Y107S,NP_000537:p.Tyr107Ser,"hg19,17:g.7579367T>G, hg38,17:g.7676049T>G",,,0.854,"cBioPortal,ClinVar,saturation_mutlist",142414,Uncertain significance,1,,,,,2.52963,2.2676540279388426,3.0705199999999997,4.42747793422619,2.8000749999999996,3.478553967113095,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,0.35761916164240065,0.33239811110574413,0.4919917583709395,-4.44622,3.054873333333333,4.0312042701637285,-0.6956733333333336,-0.2075078649181359,Uncertain,Uncertain,Neutral,Neutral,0.7462235091594355,0.35332198600721304,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.3436,1.2242,-22.1426,-4.2778193350046,0.3850196591047544,Uncertain,0.448,ambiguous,-3.554,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y107T,NP_000537:p.Tyr107Thr,,,,,saturation_mutlist,,,,,,,,2.51527,2.184569592475891,,3.5813726983333303,,3.048321349166665,,Uncertain,Destabilizing,,Destabilizing,0.40533281309971847,,0.4476989068021821,-4.00365,,3.318038857957287,,-0.34280557102135667,,Uncertain,,Neutral,,0.17512130894003775,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.3623,1.2242,-22.1426,-5.09348857870052,0.6883754420365267,Pathogenic,0.7256,pathogenic,-3.859,available,https://doi.org/10.1101/2022.10.22.513328 +Y107V,NP_000537:p.Tyr107Val,,,,,saturation_mutlist,,,,,,,,0.55863,2.076220865249634,,2.7112704418219025,,1.6349502209109512,,Uncertain,Destabilizing,,Neutral,0.5122760810327684,,0.43934137226737974,-4.92813,,2.2427631632101317,,-1.3426834183949343,,Uncertain,,Neutral,,0.40695560923911345,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,damaging,,-0.2727,1.2242,-8.8547,-4.6678212731293,0.0403891196651421,Benign,0.5588,ambiguous,-3.514,available,https://doi.org/10.1101/2022.10.22.513328 +Y107W,NP_000537:p.Tyr107Trp,,,,,saturation_mutlist,,,,,,,,0.3074,0.8364904499053956,,1.181868781988869,,0.7446343909944344,,Neutral,Neutral,,Neutral,0.1447968491686698,,0.4735090149206374,4.17959,,1.2920569658451533,,2.7358234829225765,,Uncertain,,Uncertain,,0.6965867946786599,24.379,3.396,3.605,6.971,,True,24.379,,uncertain,,,,True,3.605,,uncertain,,,neutral,,-0.2565,1.2242,-22.1426,-2.91834202370705,0.0519728985717454,Benign,0.2791,benign,-3.593,available,https://doi.org/10.1101/2022.10.22.513328 +G108A,NP_000537:p.Gly108Ala,"hg19,17:g.7579364C>G",,,0.668,"cBioPortal,saturation_mutlist",,,,,,,,4.26215,1.5832054567337037,1.1973933333333333,1.4734931419910238,2.7297716666666667,2.867821570995512,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.3868457358536851,0.3236391246778149,0.3425589278288378,0.05993,1.20363,1.0064577126746943,0.63178,0.5331938563373472,Neutral,Neutral,Neutral,Neutral,2.3888174482087714,0.5910416125448694,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.0759,2.4188,-5.536,-1.49794798507654,0.0214682676869079,Benign,0.1908,benign,-3.338,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G108C,NP_000537:p.Gly108Cys,"hg19,17:g.7579365C>A, hg38,17:g.7676047C>A",,7.9577918719e-06,0.654,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1487358,Conflicting classifications of pathogenicity,1,,,,,4.80119,0.8177783012390136,1.7158766666666667,1.9038987434985197,3.2585333333333333,3.35254437174926,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,0.2654283530533908,0.4896249445125206,0.52781952633844,0.14677,1.65125,1.618690696468238,0.8990100000000001,0.882730348234119,Neutral,Neutral,Neutral,Neutral,3.1078476567017677,0.6939371794981244,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.1526,2.4188,-8.8578,-1.84053211638479,0.1086093222249094,Benign,0.2214,benign,-3.612,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G108D,NP_000537:p.Gly108Asp,"hg19,17:g.7579364C>T, hg38,17:g.7676046C>T",,,0.651,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1371608,Uncertain significance,2,,,,,5.35465,1.794759202003479,2.9740366666666667,1.2302581502169276,4.164343333333333,3.292454075108464,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.3520354238295834,0.1186699541679452,0.6835321363069201,0.56757,3.389,0.9832362386264863,1.9782849999999998,0.7754031193132431,Uncertain,Neutral,Neutral,Neutral,4.255995281960104,0.8221444778498569,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.13,2.4188,-4.3344,-0.592226911613634,6.073865762796207e-07,Benign,0.2549,benign,-3.03,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G108E,NP_000537:p.Gly108Glu,,,,,saturation_mutlist,,,,,,,,5.47251,1.8641610956192016,,1.5981941035853653,,3.5353520517926826,,Uncertain,Uncertain,,Destabilizing,0.3678111975167826,,0.7579802529375737,0.63704,,1.354827980615994,,0.995933990307997,,Neutral,,Neutral,,1.132025746888076,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.1524,2.4188,-8.8578,-1.76181311704691,0.0001444444056638,Benign,0.423,ambiguous,-3.258,available,https://doi.org/10.1101/2022.10.22.513328 +G108F,NP_000537:p.Gly108Phe,,,,,saturation_mutlist,,,,,,,,4.99153,1.4680381631851196,,1.0298045109417056,,3.0106672554708527,,Uncertain,Uncertain,,Destabilizing,0.3024239588673084,,0.6588058554230796,-0.0645,,0.8701334614331366,,0.4028167307165683,,Neutral,,Neutral,,1.359441059249059,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.2585,2.4188,-22.1457,-3.25954254496378,0.194298664803543,Benign,0.7637,pathogenic,-3.802,available,https://doi.org/10.1101/2022.10.22.513328 +G108H,NP_000537:p.Gly108His,,,,,saturation_mutlist,,,,,,,,5.64366,1.3253831815719606,,0.8916561892979343,,3.267658094648967,,Uncertain,Uncertain,,Destabilizing,0.4274501006310534,,0.684406543780227,0.45297,,0.7820843911835875,,0.6175271955917938,,Neutral,,Neutral,,1.082801228800713,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.1347,2.4188,-2.8356,-1.56882317937165,0.0142487504878981,Benign,0.3437,ambiguous,-3.381,available,https://doi.org/10.1101/2022.10.22.513328 +G108I,NP_000537:p.Gly108Ile,,,,,saturation_mutlist,,,,,,,,7.22801,2.0755572843551637,,2.9077945175903053,,5.0679022587951525,,Uncertain,Destabilizing,,Destabilizing,0.273677129273923,,0.9371956149723205,0.30568,,1.610017990906351,,0.9578489954531755,,Neutral,,Neutral,,1.427010913496208,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.3042,2.4188,-22.1457,-4.2455659841863,0.4946248092626925,Uncertain,0.7466,pathogenic,-3.949,available,https://doi.org/10.1101/2022.10.22.513328 +G108K,NP_000537:p.Gly108Lys,,,,,saturation_mutlist,,,,,,,,4.43242,1.587594017982483,,1.057892639095812,,2.745156319547906,,Uncertain,Uncertain,,Uncertain,0.5507626091569416,,0.7046616077177915,-0.34069,,1.1158714061944717,,0.38759070309723587,,Neutral,,Neutral,,1.1256504353488792,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.2531,2.4188,-22.1457,-4.17457807775078,0.1546742590764195,Benign,0.5099,ambiguous,-3.607,available,https://doi.org/10.1101/2022.10.22.513328 +G108L,NP_000537:p.Gly108Leu,,,,,saturation_mutlist,,,,,,,,4.92964,1.4914300727844239,,1.2520949526194627,,3.0908674763097315,,Uncertain,Uncertain,,Destabilizing,0.30805059005422625,,0.7638847272666814,-0.46398,,0.8658657922715826,,0.20094289613579128,,Neutral,,Neutral,,1.2451553060009062,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.2046,2.4188,-8.8578,-2.94413681936001,0.0896168272666343,Benign,0.658,pathogenic,-3.64,available,https://doi.org/10.1101/2022.10.22.513328 +G108M,NP_000537:p.Gly108Met,,,,,saturation_mutlist,,,,,,,,4.98255,1.4663993573188783,,1.31991812022093,,3.1512340601104647,,Uncertain,Uncertain,,Destabilizing,0.34317744925303384,,0.6695143226374765,-0.40273,,0.9826901653025016,,0.28998008265125086,,Neutral,,Neutral,,0.9510580189440021,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.2106,2.4188,-22.1457,-4.2455659841863,0.5553894159457928,Uncertain,0.7367,pathogenic,-3.96,available,https://doi.org/10.1101/2022.10.22.513328 +G108N,NP_000537:p.Gly108Asn,,,,,saturation_mutlist,,,,,,,,4.64131,1.2785154819488525,,0.7902870950654584,,2.715798547532729,,Uncertain,Uncertain,,Uncertain,0.48651884229182124,,0.6406939207364727,0.01982,,0.576210927343274,,0.29801546367163695,,Neutral,,Neutral,,0.6706835676455147,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.1351,2.4188,-5.273,-0.567752297695312,7.947562315688327e-05,Benign,0.206,benign,-3.041,available,https://doi.org/10.1101/2022.10.22.513328 +G108P,NP_000537:p.Gly108Pro,,,,,saturation_mutlist,,,,,,,,9.84271,2.6461912250518798,,7.269923753331994,,8.556316876665997,,Destabilizing,Destabilizing,,Destabilizing,0.29771626617634456,,0.8193347000096223,-0.50351,,4.36979768623627,,1.933143843118135,,Uncertain,,Neutral,,0.7661906759277164,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.3183,2.4188,-22.1457,-4.96854621939755,0.4838326940140388,Uncertain,0.9416,pathogenic,-3.782,available,https://doi.org/10.1101/2022.10.22.513328 +G108Q,NP_000537:p.Gly108Gln,,,,,saturation_mutlist,,,,,,,,5.19866,1.5910159015655518,,1.4802217506034987,,3.3394408753017495,,Uncertain,Uncertain,,Destabilizing,0.451743546576932,,0.6502072344840397,0.09161,,1.2732358207369938,,0.6824229103684969,,Neutral,,Neutral,,0.9051557022587513,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.1563,2.4188,-8.8578,-2.14100404577522,0.0029453336238873,Benign,0.3805,ambiguous,-3.355,available,https://doi.org/10.1101/2022.10.22.513328 +G108R,NP_000537:p.Gly108Arg,"hg19,17:g.7579365C>G, hg38,17:g.7676047C>G",,,0.724,"COSMIC,ClinVar,saturation_mutlist",458535,Uncertain significance,2,,,,,4.67146,1.68420236825943,1.4395699999999998,0.879190932819948,3.0555149999999998,2.775325466409974,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.5257801072149596,0.1583074736075338,0.5997889084735295,-0.11997,2.9396833333333334,1.0133180151431518,1.4098566666666668,0.4466740075715759,Uncertain,Neutral,Neutral,Neutral,5.197586170658667,1.2480861017348523,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.1613,2.4188,-7.273,-2.2979062061763,0.006206502787866,Benign,0.3172,benign,-3.402,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G108S,NP_000537:p.Gly108Ser,"hg19,17:g.7579365C>T, hg19,17:g.7676047C>T, hg38,17:g.7676047C>T",,1.19366878079e-05,0.612,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142431,Likely benign,3,,,,,4.80247,1.6793345785140992,1.3340133333333333,1.512608829233124,3.0682416666666663,3.157539414616562,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.42698210336553766,0.3263775182548918,0.40096161971658373,0.38846,1.88322,1.0206143498483977,1.13584,0.7045371749241989,Neutral,Neutral,Neutral,Neutral,3.337098065395542,0.4366516650920694,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.0618,2.4188,-1.6196,-1.31631783038784,0.0005365714941366,Benign,0.1259,benign,-3.156,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G108T,NP_000537:p.Gly108Thr,,,,,saturation_mutlist,,,,,,,,7.38525,2.0587864542007446,,2.406263151969337,,4.895756575984668,,Uncertain,Destabilizing,,Destabilizing,0.39283444050575705,,0.5845267786397453,0.59306,,1.5859111006285855,,1.0894855503142928,,Neutral,,Neutral,,0.962998457881899,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.1455,2.4188,-2.9511,-1.68965030779181,0.600777146333076,Uncertain,0.3901,ambiguous,-3.656,available,https://doi.org/10.1101/2022.10.22.513328 +G108V,NP_000537:p.Gly108Val,"hg19,17:g.7579364C>A, hg19,17:g.7676046C>A, hg38,17:g.7676046C>A",,,0.658,"cBioPortal,ClinVar,saturation_mutlist",1729287,Uncertain significance,1,,,,,7.24045,2.0488980531692507,4.82585,2.5470910559695983,6.03315,4.893770527984799,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.2680282491851217,0.24056062950255744,0.8134690892631934,0.46224,2.825623333333333,1.5849746661286603,1.6439316666666666,1.02360733306433,Uncertain,Neutral,Neutral,Neutral,4.580294365360763,1.3516767335408586,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.2474,2.4188,-22.1457,-3.87038867333747,0.5655542104368011,Uncertain,0.6061,pathogenic,-3.749,available,https://doi.org/10.1101/2022.10.22.513328 +G108W,NP_000537:p.Gly108Trp,,,,,saturation_mutlist,,,,,,,,6.26895,1.7475229072570801,,0.8216485866652086,,3.5452992933326044,,Uncertain,Uncertain,,Destabilizing,0.25767795367662877,,0.5775296658004645,0.44331,,0.7768749752792384,,0.6100924876396192,,Neutral,,Neutral,,1.3424263795836133,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.2583,2.4188,-22.1457,-3.25954254496378,0.5745409340710443,Uncertain,0.6991,pathogenic,-4.093,available,https://doi.org/10.1101/2022.10.22.513328 +G108Y,NP_000537:p.Gly108Tyr,,,,,saturation_mutlist,,,,,,,,5.21113,1.6509520244598388,,1.129192750969758,,3.170161375484879,,Uncertain,Uncertain,,Destabilizing,0.2863178835144212,,0.5996325303249456,0.04532,,0.9366226520909695,,0.49097132604548477,,Neutral,,Neutral,,1.278621609350926,9.977,5.768,26.055,11.817,,True,9.977,,neutral,neutral,neutral,,True,26.055,,neutral,neutral,neutral,neutral,,-0.2589,2.4188,-22.1457,-3.25954254496378,0.5037951790693465,Uncertain,0.5776,pathogenic,-3.78,available,https://doi.org/10.1101/2022.10.22.513328 +F109A,NP_000537:p.Phe109Ala,,,,,saturation_mutlist,,,,,,,,5.2683,2.280126461982727,,4.38362967805158,,4.82596483902579,,Destabilizing,Destabilizing,,Destabilizing,0.37151898816449985,,0.19537413185897867,0.84821,,3.2594476203176277,,2.053828810158814,,Uncertain,,Uncertain,,0.3716864626722425,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.436,0.1397,-22.1457,-7.31938189731103,0.848125609305831,Pathogenic,0.9976,pathogenic,-4.468,available,https://doi.org/10.1101/2022.10.22.513328 +F109C,NP_000537:p.Phe109Cys,"hg19,17:g.7579361A>C, hg19,17:g.7676043A>C, hg38,17:g.7676043A>C",,,0.965,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634784,Likely pathogenic,1,,,,,5.05983,1.4832185411453247,3.9980733333333327,4.465418988855035,4.528951666666666,4.762624494427517,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.3111112498997338,0.7398611359047197,0.2392146346134595,0.77391,3.38424,3.205016887538705,2.079075,1.9894634437693524,Uncertain,Uncertain,Uncertain,Neutral,0.15428825295530435,0.43574895396272223,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.4041,0.1397,-22.1457,-7.31938189731103,0.8652860751663696,Pathogenic,0.9844,pathogenic,-4.392,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F109D,NP_000537:p.Phe109Asp,,,,,saturation_mutlist,,,,,,,,5.87575,2.7905950260162355,,5.548196233862439,,5.711973116931219,,Destabilizing,Destabilizing,,Destabilizing,0.2725905546188836,,0.08621891913874195,2.86788,,4.373830445976462,,3.620855222988231,,Uncertain,,Destabilizing,,0.5921689509617675,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.5589,0.1397,-22.1457,-7.31938189731103,0.8650156903297376,Pathogenic,0.9995,pathogenic,-4.754,available,https://doi.org/10.1101/2022.10.22.513328 +F109E,NP_000537:p.Phe109Glu,,,,,saturation_mutlist,,,,,,,,5.90077,2.8381051063537597,,5.021631053525215,,5.461200526762607,,Destabilizing,Destabilizing,,Destabilizing,0.2784595994866019,,0.20633117553127142,3.29775,,4.055898836865185,,3.6768244184325924,,Destabilizing,,Destabilizing,,0.5279655204132212,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.5283,0.1397,-22.1457,-7.31938189731103,0.8708635610686242,Pathogenic,0.9994,pathogenic,-4.678,available,https://doi.org/10.1101/2022.10.22.513328 +F109G,NP_000537:p.Phe109Gly,,,,,saturation_mutlist,,,,,,,,6.51738,2.67354088306427,,6.160243807337975,,6.338811903668987,,Destabilizing,Destabilizing,,Destabilizing,0.31005725903815606,,0.2302504791093188,1.14725,,4.932630121620364,,3.0399400608101823,,Uncertain,,Destabilizing,,0.5304844045523844,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.4713,0.1397,-22.1457,-7.31938189731103,0.8708540421658563,Pathogenic,0.9973,pathogenic,-4.63,available,https://doi.org/10.1101/2022.10.22.513328 +F109H,NP_000537:p.Phe109His,,,,,saturation_mutlist,,,,,,,,3.96241,2.786045551300049,,2.6487497400292117,,3.305579870014606,,Uncertain,Destabilizing,,Destabilizing,0.38400601682726243,,0.1469600618592725,2.14779,,2.20810440595219,,2.177947202976095,,Uncertain,,Uncertain,,0.5639461262440625,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.4635,0.1397,-22.1457,-4.40622457131549,0.8695787551898566,Pathogenic,0.9969,pathogenic,-4.486,available,https://doi.org/10.1101/2022.10.22.513328 +F109I,NP_000537:p.Phe109Ile,"hg19,17:g.7579362A>T, hg38,17:g.7676044A>T",,,0.837,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2627017,Likely pathogenic,2,,,,,3.6281,1.1356135606765747,3.993536666666666,3.1414971205447646,3.8108183333333328,3.3847985602723822,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.38877914479237496,0.40216124530121283,0.11265416683766125,0.40847,2.1591833333333335,1.9003787816045214,1.2838266666666667,1.1544243908022607,Uncertain,Neutral,Neutral,Neutral,0.4033035112941893,0.40527201975582916,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.3799,0.1397,-22.1457,-6.12358780216624,0.8692404219148717,Pathogenic,0.9571,pathogenic,-4.289,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F109K,NP_000537:p.Phe109Lys,,,,,saturation_mutlist,,,,,,,,5.14566,2.875238151550293,,5.466737648036691,,5.306198824018345,,Destabilizing,Destabilizing,,Destabilizing,0.26779072468454035,,0.2716543546425866,3.22896,,4.606280401825383,,3.9176202009126913,,Destabilizing,,Destabilizing,,0.7787983482429113,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.5352,0.1397,-22.1457,-7.31938189731103,0.8707599885307575,Pathogenic,0.9991,pathogenic,-4.709,available,https://doi.org/10.1101/2022.10.22.513328 +F109L,NP_000537:p.Phe109Leu,"hg19,17:g.7579360G>T, hg38,17:g.7676042G>T",,,0.715,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.70118,1.3720639562606811,2.06678,2.279546780394441,2.38398,2.4903633901972206,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.2787413731610058,0.9396896071575975,0.3047416019723312,0.60501,2.47812,1.3298070257714187,1.541565,0.9674085128857094,Uncertain,Neutral,Neutral,Neutral,0.36325812016617964,0.16554992230194615,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.261,0.1397,-6.273,-3.87109101487644,0.000299253831507,Benign,0.9839,pathogenic,-3.413,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F109M,NP_000537:p.Phe109Met,,,,,saturation_mutlist,,,,,,,,1.98253,1.2420403814315797,,2.6303966351455963,,2.306463317572798,,Uncertain,Uncertain,,Uncertain,0.24526749493908884,,0.20445286727119683,-0.71058,,1.874287550633279,,0.5818537753166395,,Neutral,,Neutral,,0.3989289940720175,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.373,0.1397,-22.1457,-6.12358780216624,0.8610876314967335,Pathogenic,0.9667,pathogenic,-4.347,available,https://doi.org/10.1101/2022.10.22.513328 +F109N,NP_000537:p.Phe109Asn,"hg19,17:g.7579361_7579363inv, hg38,17:g.7676043_7676045inv",,,,"ClinVar,saturation_mutlist",2417541,Uncertain significance,1,,,,,5.39595,2.7784231662750245,4.243196666666667,4.283753878140195,4.8195733333333335,4.839851939070098,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.25711650181997553,0.681965688889274,0.26176517346380757,2.03129,4.169953333333333,3.1238736470444337,3.100621666666666,2.577581823522217,Uncertain,Uncertain,Destabilizing,Uncertain,0.2639360950853233,0.4939910320349562,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.4886,0.1397,-22.1457,-7.31938189731103,0.8645942659804584,Pathogenic,0.9983,pathogenic,-4.67,available,https://doi.org/10.1101/2022.10.22.513328 +F109P,NP_000537:p.Phe109Pro,,,,,saturation_mutlist,,,,,,,,7.27067,2.3811313343048095,,9.11342855134987,,8.192049275674934,,Destabilizing,Destabilizing,,Destabilizing,0.3140856522618575,,0.7895708881861676,3.86028,,7.818522097520646,,5.839401048760323,,Destabilizing,,Destabilizing,,1.3650940471853605,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.5593,0.1397,-22.1457,-7.31938189731103,0.8708609535611396,Pathogenic,0.9998,pathogenic,-4.494,available,https://doi.org/10.1101/2022.10.22.513328 +F109Q,NP_000537:p.Phe109Gln,,,,,saturation_mutlist,,,,,,,,5.19379,2.7973312187194823,,4.250968215792104,,4.722379107896051,,Destabilizing,Destabilizing,,Destabilizing,0.29707195191269326,,0.1174767696917525,2.33302,,3.093208176373416,,2.7131140881867077,,Uncertain,,Uncertain,,0.5208468544050567,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.4906,0.1397,-22.1457,-7.31938189731103,0.8655107856719801,Pathogenic,0.9988,pathogenic,-4.582,available,https://doi.org/10.1101/2022.10.22.513328 +F109R,NP_000537:p.Phe109Arg,,,,,saturation_mutlist,,,,,,,,5.82028,2.7434319972991945,,4.303866408708718,,5.062073204354359,,Destabilizing,Destabilizing,,Destabilizing,0.22646580702912006,,0.061233091184772735,5.86487,,3.462444987989388,,4.663657493994694,,Destabilizing,,Destabilizing,,0.7358031503187418,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.5366,0.1397,-22.1457,-7.31938189731103,0.8704784288805557,Pathogenic,0.9975,pathogenic,-4.652,available,https://doi.org/10.1101/2022.10.22.513328 +F109S,NP_000537:p.Phe109Ser,"hg19,17:g.7579361A>G, hg19,17:g.7676043A>G, hg38,17:g.7676043A>G",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",423970,Uncertain significance,2,,,,,6.3279,2.3267938137054442,5.02109,5.299410812042382,5.674495,5.813655406021191,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.3275767409145648,0.8196954434829233,0.12084876406098585,1.76073,4.53254,4.090569452787202,3.146635,2.9256497263936008,Uncertain,Uncertain,Destabilizing,Uncertain,0.4008143351561503,0.5681344160382689,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.4149,0.1397,-22.1457,-7.31938189731103,0.8704216588436751,Pathogenic,0.9989,pathogenic,-4.476,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F109T,NP_000537:p.Phe109Thr,,,,,saturation_mutlist,,,,,,,,5.67014,2.269594783782959,,4.37352614283807,,5.021833071419035,,Destabilizing,Destabilizing,,Destabilizing,0.35107994660257363,,0.18697157637873282,1.76112,,3.247301205680835,,2.504210602840417,,Uncertain,,Uncertain,,0.6286858654158322,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.4612,0.1397,-22.1457,-7.31938189731103,0.8625526186042833,Pathogenic,0.9984,pathogenic,-4.526,available,https://doi.org/10.1101/2022.10.22.513328 +F109V,NP_000537:p.Phe109Val,"hg19,17:g.7579362A>C, hg19,17:g.7676044A>C, hg38,17:g.7676044A>C",,,0.875,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",389644,Conflicting classifications of pathogenicity,1,,,,,3.97066,1.1897403240203857,3.1877566666666666,3.31138315011078,3.5792083333333333,3.6410215750553903,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.4108604201013463,0.15094644576434685,0.22128118024193594,0.22905,2.396373333333333,2.0250255111917563,1.3127116666666665,1.1270377555958782,Uncertain,Uncertain,Neutral,Neutral,0.4268283336684928,0.42920226574240405,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.3013,0.1397,-7.8579,-6.12358780216624,0.8608460390800319,Pathogenic,0.9749,pathogenic,-4.192,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F109W,NP_000537:p.Phe109Trp,,,,,saturation_mutlist,,,,,,,,2.57576,1.0381712579727174,,0.8164216299023236,,1.6960908149511618,,Uncertain,Uncertain,,Neutral,0.4414897906903449,,0.11306763008996491,6.85272,,1.0717955702436113,,3.9622577851218055,,Uncertain,,Destabilizing,,0.40694639004802013,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,neutral,,-0.3595,0.1397,-22.1457,-4.40622457131549,0.8708214964107495,Pathogenic,0.9532,pathogenic,-4.493,available,https://doi.org/10.1101/2022.10.22.513328 +F109Y,NP_000537:p.Phe109Tyr,"hg19,17:g.7579361A>T, hg38,17:g.7676043A>T",,,0.848,"cBioPortal,ClinVar,saturation_mutlist",1054035,Uncertain significance,1,,,,,1.60958,1.4552599287033081,0.54093,0.7117830835394617,1.075255,1.160681541769731,Neutral,Neutral,Uncertain,Neutral,Neutral,0.4120109340347211,0.25776459661223194,0.18093958455900486,2.08873,1.3953533333333332,0.9886574994347642,1.7420416666666667,1.538693749717382,Uncertain,Uncertain,Neutral,Neutral,0.280993714559992,0.4469744220421143,0.506,0.551,0.415,0.545,,True,0.506,,neutral,neutral,neutral,,True,0.415,,neutral,neutral,neutral,uncertain,,-0.3278,0.1397,-22.1457,-4.40622457131549,0.8641792744217547,Pathogenic,0.8463,pathogenic,-4.13,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110A,NP_000537:p.Arg110Ala,,,,,saturation_mutlist,,,,,,,,0.98652,0.7737426829338073,,0.7198318565783226,,0.8531759282891613,,Neutral,Neutral,,Neutral,0.22737309604521527,,0.14702387615148405,0.56834,,0.7930362012581099,,0.6806881006290549,,Neutral,,Neutral,,0.13511078065301532,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.1271,2.3313,-8.8578,-1.9647838107166,0.0004081953569178,Benign,0.3074,benign,-3.389,available,https://doi.org/10.1101/2022.10.22.513328 +R110C,NP_000537:p.Arg110Cys,"hg19,17:g.7579359G>A, hg19,17:g.7579359_7579360delinsAA, hg19,17:g.7676041G>A, hg38,17:g.7676041G>A, hg38,17:g.7676041_7676042delinsAA",,1.98974881411e-05,0.471,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142206,Uncertain significance,3,Uncertain significance,1,,,0.83615,0.7951711964607239,1.5629266666666668,1.239424073376668,1.1995383333333334,1.037787036688334,Neutral,Neutral,Neutral,Neutral,Neutral,0.15339279180765522,0.33748119723754816,0.15714409543310495,0.5029,0.8064633333333333,1.201154091967136,0.6546816666666666,0.8520270459835679,Neutral,Neutral,Neutral,Neutral,0.7403410215269417,0.06490239501804593,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.1241,2.3313,-6.536,-1.39081632871217,2.756682742910876e-06,Benign,0.0983,benign,-3.214,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110D,NP_000537:p.Arg110Asp,,,,,saturation_mutlist,,,,,,,,1.05753,2.156891918182373,,1.1243497529295592,,1.0909398764647795,,Neutral,Destabilizing,,Neutral,0.2760398350425515,,0.1391542713735226,0.8536,,0.9683622416372426,,0.9109811208186214,,Neutral,,Neutral,,0.23647504766082447,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.1785,2.3313,-1.0898,-1.15873468370403,6.302676267013781e-05,Benign,0.389,ambiguous,-3.109,available,https://doi.org/10.1101/2022.10.22.513328 +R110E,NP_000537:p.Arg110Glu,,,,,saturation_mutlist,,,,,,,,0.95681,1.727991533279419,,0.696194167960038,,0.826502083980019,,Neutral,Uncertain,,Neutral,0.23291503298422234,,0.06324369226385332,0.61674,,0.6762300016771864,,0.6464850008385932,,Neutral,,Neutral,,0.17615199515481655,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.1317,2.3313,-2.6485,-0.0195238306738232,6.058390849595864e-07,Benign,0.2304,benign,-2.984,available,https://doi.org/10.1101/2022.10.22.513328 +R110F,NP_000537:p.Arg110Phe,,,,,saturation_mutlist,,,,,,,,0.28383,1.1536688303947449,,0.1330028728135798,,0.20841643640678992,,Neutral,Uncertain,,Neutral,0.17603462830897176,,0.2617644886166053,-0.05773,,0.01058469443377453,,-0.023572652783112734,,Neutral,,Neutral,,0.11697929326382749,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.227,2.3313,-22.1457,-2.79267633772652,0.0096157920499123,Benign,0.3533,ambiguous,-3.673,available,https://doi.org/10.1101/2022.10.22.513328 +R110G,NP_000537:p.Arg110Gly,"hg19,17:g.7579359G>C, hg38,17:g.7676041G>C",,,0.577,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",823452,Likely pathogenic,3,,,,,1.321,1.318390700817108,2.68209,1.4694285779208889,2.001545,1.3952142889604444,Uncertain,Neutral,Uncertain,Uncertain,Neutral,0.3424319547000795,0.03194392273970119,0.15986831329342371,0.93069,1.6834466666666665,1.4970178754959278,1.3070683333333333,1.213853937747964,Neutral,Neutral,Neutral,Neutral,0.5869539779990326,0.23790502173274375,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.2303,2.3313,-22.1457,-3.3371356995395,0.0037290696055361,Benign,0.2211,benign,-3.364,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110H,NP_000537:p.Arg110His,"hg19,17:g.7579358C>T, hg38,17:g.7676040C>T",3.18694626809e-05,4.7754731698e-05,0.592,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127808,Likely benign,3,,,,,1.0972,0.9447195172309876,0.87857,0.3478873007051076,0.9878849999999999,0.7225436503525537,Neutral,Neutral,Neutral,Neutral,Neutral,0.15285270916991706,0.19090077282888795,0.18811375156966062,0.89647,0.3098666666666667,0.24255223155616176,0.6031683333333333,0.5695111157780809,Neutral,Neutral,Neutral,Neutral,0.42832363856732864,0.100608619204127,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.0748,2.3313,-4.5361,-0.70853961877809,2.8171827076627353e-10,Benign,0.0631,benign,-2.962,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110I,NP_000537:p.Arg110Ile,,,,,saturation_mutlist,,,,,,,,0.81153,1.0053062963485717,,0.11857926996582684,,0.4650546349829134,,Neutral,Uncertain,,Neutral,0.2052320902602343,,0.15126088055165066,0.59006,,0.20500329609296095,,0.3975316480464805,,Neutral,,Neutral,,0.11527313618970698,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.2243,2.3313,-22.1457,-3.36954043060331,0.140141726442351,Benign,0.2669,benign,-3.834,available,https://doi.org/10.1101/2022.10.22.513328 +R110K,NP_000537:p.Arg110Lys,,,,,saturation_mutlist,,,,,,,,0.37052,0.4219205331802368,,0.35608885776256943,,0.3633044288812847,,Neutral,Neutral,,Neutral,0.06261571266717943,,0.16865089484801377,0.03128,,0.4992043191255246,,0.2652421595627623,,Neutral,,Neutral,,0.11110737470463887,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,uncertain,,0.0026,2.3313,-4.9511,-1.20405873836924,2.935192105769949e-07,Benign,0.1216,benign,-2.942,available,https://doi.org/10.1101/2022.10.22.513328 +R110L,NP_000537:p.Arg110Leu,"hg19,17:g.7579358C>A, hg19,17:g.7676040C>A, hg38,17:g.7676040C>A",,0.0,0.632,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406597,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,0.59942,1.344319713115692,1.02982,-0.013518402098111601,0.8146199999999999,0.29295079895094417,Neutral,Neutral,Uncertain,Neutral,Neutral,0.18661340253718742,0.6894644142134289,0.060818875494595394,0.056,0.33854999999999996,0.042625320546934964,0.19727499999999998,0.04931266027346748,Neutral,Neutral,Neutral,Neutral,0.6988608634532818,0.08615266205510622,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.1244,2.3313,-7.8579,-2.17467226116893,0.000308078665055,Benign,0.2152,benign,-3.443,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110M,NP_000537:p.Arg110Met,,,,,saturation_mutlist,,,,,,,,0.25906,0.9626519632339477,,0.3494862427872996,,0.3042731213936498,,Neutral,Neutral,,Neutral,0.13335187967983209,,0.05720607526163934,-0.07397,,0.35912841028339954,,0.14257920514169978,,Neutral,,Neutral,,0.04788645844037987,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.1632,2.3313,-22.1457,-3.72679073233043,0.0789149760461895,Benign,0.3399,benign,-3.773,available,https://doi.org/10.1101/2022.10.22.513328 +R110N,NP_000537:p.Arg110Asn,,,,,saturation_mutlist,,,,,,,,1.0794,1.242858853340149,,0.7951952282811071,,0.9372976141405536,,Neutral,Uncertain,,Neutral,0.1994783847015032,,0.17175638937216525,0.88212,,0.6728941611313934,,0.7775070805656967,,Neutral,,Neutral,,0.1000350123040508,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.1318,2.3313,-6.858,-1.06687406706304,1.6016189840234238e-05,Benign,0.3016,benign,-3.088,available,https://doi.org/10.1101/2022.10.22.513328 +R110P,NP_000537:p.Arg110Pro,"hg19,17:g.7579357_7579358delinsGG, hg19,17:g.7579358C>G, hg19,17:g.7676040C>G, hg38,17:g.7676039_7676040delinsGG, hg38,17:g.7676040C>G",,,0.593,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","641505, 233627","Pathogenic, Pathogenic","1, 3",Oncogenic,1,Tier I - Strong,1,5.14927,3.2057511043548583,7.937639999999999,4.488239002910404,6.543455,4.818754501455201,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.27638146507803935,0.6390950074910613,1.0649575679408125,3.73284,2.107936666666667,3.0881321031092455,2.9203883333333334,3.4104860515546225,Uncertain,Destabilizing,Uncertain,Destabilizing,0.42436302331324255,1.0217897893114385,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.337,2.3313,-22.1457,-4.23188871816848,0.0752451657410477,Benign,0.9045,pathogenic,-3.666,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110Q,NP_000537:p.Arg110Gln,,,,,saturation_mutlist,,,,,,,,0.663,0.9320120143890381,,0.7102054496316391,,0.6866027248158195,,Neutral,Neutral,,Neutral,0.14333842491174995,,0.05507884466497503,0.32308,,0.6454173069119257,,0.4842486534559628,,Neutral,,Neutral,,0.07773967458108039,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.0736,2.3313,-3.3344,0.126450236844939,2.152850264199561e-09,Benign,0.0792,benign,-2.879,available,https://doi.org/10.1101/2022.10.22.513328 +R110S,NP_000537:p.Arg110Ser,"hg19,17:g.7579359G>T, hg38,17:g.7676041G>T",,,0.525,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",140921,Uncertain significance,2,,,,,0.91206,0.5170254492759705,1.47381,0.9642744642445672,1.192935,0.9381672321222836,Neutral,Neutral,Neutral,Neutral,Neutral,0.2476852918688325,0.2310159753494694,0.1208478603442283,0.56343,0.96576,0.9403774141473497,0.7645949999999999,0.7519037070736748,Neutral,Neutral,Neutral,Neutral,0.10820987231609998,0.2032057991803059,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.1954,2.3313,-22.1457,-2.41640473303228,2.399367523182605e-05,Benign,0.2343,benign,-3.178,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110T,NP_000537:p.Arg110Thr,,,,,saturation_mutlist,,,,,,,,1.06527,0.6436451959609986,,0.6784142738537821,,0.8718421369268909,,Neutral,Neutral,,Neutral,0.15291227961736475,,0.13608639872665543,0.72473,,0.6854110132448535,,0.7050705066224268,,Neutral,,Neutral,,0.1460384033850872,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.115,2.3313,-5.536,-1.61795210105221,1.1441533290724637e-06,Benign,0.1674,benign,-2.992,available,https://doi.org/10.1101/2022.10.22.513328 +R110V,NP_000537:p.Arg110Val,,,,,saturation_mutlist,,,,,,,,1.08798,0.917678747177124,,0.2857577010928202,,0.6868688505464101,,Neutral,Neutral,,Neutral,0.22379574632806434,,0.14243465747659537,0.92776,,0.3183519916095299,,0.623055995804765,,Neutral,,Neutral,,0.10449860131301626,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.2114,2.3313,-22.1457,-3.72679073233043,0.0298696001719312,Benign,0.2727,benign,-3.668,available,https://doi.org/10.1101/2022.10.22.513328 +R110W,NP_000537:p.Arg110Trp,,,,,saturation_mutlist,,,,,,,,0.62558,1.233839032649994,,-0.16648393649960883,,0.2295480317501956,,Neutral,Uncertain,,Neutral,0.22525202589817858,,0.2251050899246125,0.69233,,-0.21507674495330856,,0.23862662752334574,,Neutral,,Neutral,,0.18098388890872183,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.2126,2.3313,-22.1457,-3.29847407890407,0.0804512369816558,Benign,0.1749,benign,-3.93,available,https://doi.org/10.1101/2022.10.22.513328 +R110Y,NP_000537:p.Arg110Tyr,,,,,saturation_mutlist,,,,,,,,0.41517,1.1110863018035888,,0.23354547713697363,,0.3243577385684868,,Neutral,Uncertain,,Neutral,0.20608808995027658,,0.24668110061292137,0.16254,,0.1166647381300608,,0.1396023690650304,,Neutral,,Neutral,,0.1248576872371822,40.26,6.733,65.27,10.092,,False,40.26,,neutral,neutral,neutral,,False,65.27,,neutral,neutral,neutral,damaging,,-0.2163,2.3313,-22.1457,-2.83717329368476,0.0297454375782944,Benign,0.2093,benign,-3.657,available,https://doi.org/10.1101/2022.10.22.513328 +L111A,NP_000537:p.Leu111Ala,,,,,saturation_mutlist,,,,,,,,4.03821,1.727731738090515,,3.428525534727908,,3.733367767363954,,Destabilizing,Uncertain,,Destabilizing,0.38851911970191083,,0.26749107144133916,0.13093,,3.190852382224555,,1.6608911911122775,,Uncertain,,Neutral,,0.16870966606558352,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.3209,1.0662,-22.1488,-6.30801522472044,0.7161328193554986,Pathogenic,0.8123,pathogenic,-4.048,available,https://doi.org/10.1101/2022.10.22.513328 +L111C,NP_000537:p.Leu111Cys,,,,,saturation_mutlist,,,,,,,,3.14499,0.8249475693702698,,3.4166374932511947,,3.280813746625597,,Destabilizing,Neutral,,Destabilizing,0.26433289243691493,,0.16093403991336275,0.34995,,3.150430322938656,,1.750190161469328,,Uncertain,,Neutral,,0.2552816065007865,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.3102,1.0662,-22.1488,-6.40292243487766,0.6454205371135974,Uncertain,0.8415,pathogenic,-4.215,available,https://doi.org/10.1101/2022.10.22.513328 +L111D,NP_000537:p.Leu111Asp,,,,,saturation_mutlist,,,,,,,,4.68887,2.5505467891693114,,4.619581646465209,,4.654225823232604,,Destabilizing,Destabilizing,,Destabilizing,0.3284056053339031,,0.05326175908399037,2.47397,,4.298623522076154,,3.3862967610380768,,Uncertain,,Destabilizing,,0.03358256504889308,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.4425,1.0662,-22.1488,-6.86455845713059,0.8592931658937847,Pathogenic,0.9981,pathogenic,-4.584,available,https://doi.org/10.1101/2022.10.22.513328 +L111E,NP_000537:p.Leu111Glu,,,,,saturation_mutlist,,,,,,,,4.14283,2.4422924423217776,,4.14829046772975,,4.145560233864876,,Destabilizing,Destabilizing,,Destabilizing,0.3220574241336579,,0.18083529055412992,2.64744,,3.741247994075298,,3.194343997037649,,Uncertain,,Destabilizing,,0.12171801821857732,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.4105,1.0662,-22.1488,-6.86455845713059,0.8700309809272802,Pathogenic,0.9862,pathogenic,-4.526,available,https://doi.org/10.1101/2022.10.22.513328 +L111F,NP_000537:p.Leu111Phe,,,,,saturation_mutlist,,,,,,,,3.81818,0.845813992023468,,1.4918381788662518,,2.655009089433126,,Uncertain,Neutral,,Uncertain,0.27984586591431504,,0.0966278197336401,6.97546,,1.4829507613577675,,4.229205380678883,,Uncertain,,Destabilizing,,0.41683219224413637,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.2544,1.0662,-22.1488,-4.8343986237693,0.4240487719978994,Uncertain,0.7154,pathogenic,-3.795,available,https://doi.org/10.1101/2022.10.22.513328 +L111G,NP_000537:p.Leu111Gly,,,,,saturation_mutlist,,,,,,,,5.02484,2.2286960744857787,,5.458458560237719,,5.2416492801188594,,Destabilizing,Destabilizing,,Destabilizing,0.37913739221013654,,0.2323878739462484,1.27639,,5.085513653668811,,3.1809518268344057,,Uncertain,,Destabilizing,,0.0868213262790804,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.3958,1.0662,-22.1488,-6.86455845713059,0.8708634107215206,Pathogenic,0.9746,pathogenic,-4.53,available,https://doi.org/10.1101/2022.10.22.513328 +L111H,NP_000537:p.Leu111His,,,,,saturation_mutlist,,,,,,,,3.92863,2.209704723358154,,2.755008296824322,,3.341819148412161,,Uncertain,Destabilizing,,Destabilizing,0.31940014615531265,,0.10467714373597044,7.35937,,2.7148498408997717,,5.037109920449886,,Uncertain,,Destabilizing,,0.09533883948169825,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.3633,1.0662,-22.1488,-6.0104303210959,0.8684440243492931,Pathogenic,0.9742,pathogenic,-4.443,available,https://doi.org/10.1101/2022.10.22.513328 +L111I,NP_000537:p.Leu111Ile,,,,,saturation_mutlist,,,,,,,,1.44982,0.005755105018615738,,1.2445876559747902,,1.347203827987395,,Neutral,Neutral,,Neutral,0.25957090576194086,,0.274206189390739,0.2578,,1.1600787356672215,,0.7089393678336108,,Neutral,,Neutral,,0.5377855703312441,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.1192,1.0662,-7.2761,-2.29501946629457,0.0518473711875908,Benign,0.1694,benign,-3.454,available,https://doi.org/10.1101/2022.10.22.513328 +L111K,NP_000537:p.Leu111Lys,,,,,saturation_mutlist,,,,,,,,3.70399,2.261815333366394,,5.347882732699406,,4.525936366349703,,Destabilizing,Destabilizing,,Destabilizing,0.321610435222488,,0.25019179770249705,4.62685,,4.67381623834907,,4.650333119174535,,Destabilizing,,Destabilizing,,0.49265031979449897,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.3417,1.0662,-8.8609,-6.86455845713059,0.8701563980423375,Pathogenic,0.9828,pathogenic,-4.594,available,https://doi.org/10.1101/2022.10.22.513328 +L111M,NP_000537:p.Leu111Met,"hg19,17:g.7579356G>T, hg19,17:g.7676038G>T, hg38,17:g.7676038G>T",,,0.517,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",836750,Uncertain significance,2,,,,,0.34424,0.8100996685028076,1.4984133333333334,1.4907653159407372,0.9213266666666666,0.9175026579703687,Neutral,Neutral,Neutral,Neutral,Neutral,0.18718290424375367,0.4070606525104363,0.13917566457638414,0.48819,1.4224500000000002,1.473014805343748,0.9553200000000002,0.980602402671874,Neutral,Neutral,Neutral,Neutral,0.4922921200533954,0.1540227003836914,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.1505,1.0662,-8.8609,-3.546138403816,0.6099948176751155,Uncertain,0.3444,ambiguous,-3.738,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L111N,NP_000537:p.Leu111Asn,,,,,saturation_mutlist,,,,,,,,3.71494,2.410753903388977,,3.2149358410212785,,3.464937920510639,,Destabilizing,Destabilizing,,Destabilizing,0.31046111202950794,,0.1096665199564751,2.17028,,3.0624915963534143,,2.616385798176707,,Uncertain,,Uncertain,,0.05124784210311314,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.3888,1.0662,-22.1488,-6.86455845713059,0.870835939386577,Pathogenic,0.9897,pathogenic,-4.54,available,https://doi.org/10.1101/2022.10.22.513328 +L111P,NP_000537:p.Leu111Pro,"hg19,17:g.7579355A>G, hg19,17:g.7676037A>G, hg38,17:g.7676037A>G",,,0.864,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376630,Pathogenic,3,,,,,3.45893,1.9717967891693116,3.77279,6.811184331448868,3.61586,5.135057165724434,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.3921515849871505,0.33579415162665743,0.8725681505199601,1.01792,3.8420633333333334,6.1985548133387445,2.4299916666666665,3.6082374066693723,Uncertain,Uncertain,Uncertain,Destabilizing,0.4576596699392343,1.33546324910512,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.4043,1.0662,-22.1488,-6.86455845713059,0.8690481369733514,Pathogenic,0.9584,pathogenic,-4.356,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L111Q,NP_000537:p.Leu111Gln,"hg19,17:g.7579355A>T, hg19,17:g.7676037A>T, hg38,17:g.7676037A>T",,,0.869,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376632,Pathogenic,3,,,,,3.22469,2.322814211845398,2.987643333333333,3.0520470715141457,3.1061666666666667,3.1383685357570728,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.3190773424042785,0.4400220123534224,0.18255859312475362,2.89446,2.8969399999999994,2.8627613784857573,2.8956999999999997,2.878610689242879,Uncertain,Uncertain,Uncertain,Uncertain,0.7284139577648595,0.058533623673955947,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.3417,1.0662,-22.1488,-6.86455845713059,0.8668508225734014,Pathogenic,0.9593,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L111R,NP_000537:p.Leu111Arg,"hg19,17:g.7579355A>C, hg19,17:g.7676037A>C, hg38,17:g.7676037A>C",,,0.862,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376631,Pathogenic,3,,,,,5.1043,2.4163648080825806,4.245466666666666,4.189862403967236,4.674883333333334,4.647081201983618,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.35493508725836087,0.9874236033008099,0.3192407161700141,7.11225,5.18356,3.6961562817400018,6.147905,5.404203140870001,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.8491492027906523,0.41652533959199095,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.4011,1.0662,-22.1488,-6.86455845713059,0.868284874800753,Pathogenic,0.9601,pathogenic,-4.569,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L111S,NP_000537:p.Leu111Ser,,,,,saturation_mutlist,,,,,,,,4.50625,2.0916603231430053,,4.361806714832927,,4.434028357416463,,Destabilizing,Destabilizing,,Destabilizing,0.3520628196541084,,0.2494562409378549,1.31763,,3.966698455063574,,2.642164227531787,,Uncertain,,Uncertain,,0.20668894513180988,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.3513,1.0662,-22.1488,-6.40292243487766,0.8387887677406434,Pathogenic,0.9683,pathogenic,-4.282,available,https://doi.org/10.1101/2022.10.22.513328 +L111T,NP_000537:p.Leu111Thr,,,,,saturation_mutlist,,,,,,,,3.45695,1.6296930837631225,,3.2836161777506168,,3.3702830888753086,,Destabilizing,Uncertain,,Destabilizing,0.3590596279686121,,0.23269291846807,1.02533,,2.924106392800335,,1.9747181964001674,,Uncertain,,Neutral,,0.4077686078726207,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.3241,1.0662,-22.1488,-6.40292243487766,0.868925185644946,Pathogenic,0.7846,pathogenic,-4.298,available,https://doi.org/10.1101/2022.10.22.513328 +L111V,NP_000537:p.Leu111Val,"hg19,17:g.7579356G>C, hg38,17:g.7676038G>C",,,0.456,"cBioPortal,ClinVar,saturation_mutlist",1730178,Likely benign,3,,,,,2.22608,0.32933810234069827,1.53594,1.633586171505238,1.88101,1.9298330857526191,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.33035634047660206,0.3475822553008137,0.2974003286016644,-0.34605,2.797506666666667,1.469804042575254,1.2257283333333335,0.5618770212876271,Uncertain,Neutral,Neutral,Neutral,1.0272240241652362,0.589872177656731,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.1219,1.0662,-0.7012,-0.706742687105901,0.0008972384760983,Benign,0.1396,benign,-3.174,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L111W,NP_000537:p.Leu111Trp,,,,,saturation_mutlist,,,,,,,,6.83055,1.319723825454712,,3.0940480488069304,,4.962299024403465,,Destabilizing,Uncertain,,Destabilizing,0.3163597911057114,,0.36956818307318745,13.83722,,2.3761717039770467,,8.106695851988523,,Uncertain,,Destabilizing,,0.5712450400120394,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.2857,1.0662,-8.8609,-6.0104303210959,0.8700690831624835,Pathogenic,0.9219,pathogenic,-4.531,available,https://doi.org/10.1101/2022.10.22.513328 +L111Y,NP_000537:p.Leu111Tyr,,,,,saturation_mutlist,,,,,,,,4.9448,1.3741962027549743,,2.762461317026851,,3.8536306585134255,,Uncertain,Uncertain,,Destabilizing,0.2947306353219925,,0.2935938811073101,9.50561,,2.393803394459887,,5.949706697229944,,Uncertain,,Destabilizing,,0.5242779609645368,17.157,4.571,3.605,4.306,,False,17.157,,neutral,neutral,neutral,,False,3.605,,neutral,neutral,neutral,uncertain,,-0.3464,1.0662,-22.1488,-6.0104303210959,0.5966286451681089,Uncertain,0.961,pathogenic,-4.182,available,https://doi.org/10.1101/2022.10.22.513328 +G112A,NP_000537:p.Gly112Ala,"hg19,17:g.7579352C>G, hg38,17:g.7676034C>G",,3.9801311851e-06,,"ClinVar,saturation_mutlist",3634433,Uncertain significance,1,,,,,0.59365,0.522671822309494,,0.6632532632262826,,0.6284516316131413,,Neutral,Neutral,,Neutral,0.47170907367607634,,0.17346998632985652,-0.32174,,0.12551912441232085,,-0.09811043779383959,,Neutral,,Neutral,,0.22382017274843238,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.0865,2.296,-5.4016,-0.899611897453184,1.2002245120436748e-05,Benign,0.1727,benign,-3.022,available,https://doi.org/10.1101/2022.10.22.513328 +G112C,NP_000537:p.Gly112Cys,"hg38,17:g.7676035C>A",,,,"COSMIC,saturation_mutlist",,,,,,,,0.66786,0.2289015531539917,0.6901366666666666,1.2218505416678098,0.6789983333333334,0.9448552708339049,Neutral,Neutral,Neutral,Neutral,Neutral,0.42404183580514976,0.29137067586762316,0.14091106011070395,-0.42314,1.5805,0.5601729863934406,0.57868,0.06851649319672029,Neutral,Neutral,Neutral,Neutral,1.7805091973552585,0.19555420911772223,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.1639,2.296,-8.8609,-1.53299814309711,0.0069231742776907,Benign,0.3776,ambiguous,-3.4,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G112D,NP_000537:p.Gly112Asp,"hg19,17:g.7579352C>T, hg38,17:g.7676034C>T",,,,"COSMIC,ClinVar,saturation_mutlist",1319402,Uncertain significance,2,,,,,1.03587,1.3983204448223114,0.0627,0.53617482714416,0.549285,0.78602241357208,Neutral,Neutral,Uncertain,Neutral,Neutral,0.36327548608741206,0.2549658339202856,0.33292876273575683,-0.37903,0.6362800000000001,0.1223734366335381,0.12862500000000004,-0.12832828168323093,Neutral,Neutral,Neutral,Neutral,1.903869858787622,0.24457445373015277,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.1644,2.296,-8.8609,-0.99843218722014,0.002859383904651,Benign,0.4302,ambiguous,-3.214,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G112E,NP_000537:p.Gly112Glu,,,,,saturation_mutlist,,,,,,,,0.83619,1.2131436204910278,,0.5114310433290664,,0.6738105216645331,,Neutral,Uncertain,,Neutral,0.4848475922413689,,0.3091720748373711,-0.26291,,0.019765669744944998,,-0.12157216512752748,,Neutral,,Neutral,,0.33353530908386636,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.1475,2.296,-5.6912,-0.972571240468379,1.0744537158384177e-05,Benign,0.3726,ambiguous,-2.97,available,https://doi.org/10.1101/2022.10.22.513328 +G112F,NP_000537:p.Gly112Phe,,,,,saturation_mutlist,,,,,,,,0.28661,0.6200933933258057,,0.12642762223761853,,0.20651881111880926,,Neutral,Neutral,,Neutral,0.5562654145225301,,0.1644867168638349,-0.99255,,-0.64282268856142,,-0.8176863442807101,,Neutral,,Neutral,,0.3109825976779839,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.2698,2.296,-22.1488,-3.64131977785257,0.1213689325946569,Benign,0.8513,pathogenic,-3.496,available,https://doi.org/10.1101/2022.10.22.513328 +G112H,NP_000537:p.Gly112His,,,,,saturation_mutlist,,,,,,,,1.35673,0.7627848553657531,,0.08623176885856064,,0.7214808844292803,,Neutral,Neutral,,Neutral,0.4750891437903701,,0.198476840399371,0.10309,,-0.48814319515043275,,-0.19252659757521637,,Neutral,,Neutral,,0.3247805271267824,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.1624,2.296,-6.0537,-1.24042594624844,5.36044749340184e-05,Benign,0.6198,pathogenic,-3.096,available,https://doi.org/10.1101/2022.10.22.513328 +G112I,NP_000537:p.Gly112Ile,,,,,saturation_mutlist,,,,,,,,1.83557,0.9196668863296509,,1.1227447662543575,,1.4791573831271787,,Neutral,Neutral,,Neutral,0.7493705672535145,,0.2527289830663027,-0.35635,,-0.07865881486182659,,-0.2175044074309133,,Neutral,,Neutral,,0.5597861844598333,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.2477,2.296,-8.8609,-1.97476964754266,0.0563689126427347,Benign,0.6777,pathogenic,-3.468,available,https://doi.org/10.1101/2022.10.22.513328 +G112K,NP_000537:p.Gly112Lys,,,,,saturation_mutlist,,,,,,,,0.43404,0.5878322148323059,,0.4694066168497549,,0.4517233084248774,,Neutral,Neutral,,Neutral,0.6327777044979056,,0.20857614412488534,-0.70621,,-0.061532356997189834,,-0.3838711784985949,,Neutral,,Neutral,,0.14695973847141883,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.2645,2.296,-22.1488,-3.40476128288232,0.0532011834913324,Benign,0.7159,pathogenic,-3.396,available,https://doi.org/10.1101/2022.10.22.513328 +G112L,NP_000537:p.Gly112Leu,,,,,saturation_mutlist,,,,,,,,0.39012,0.642328007221222,,0.1179185296945127,,0.25401926484725634,,Neutral,Neutral,,Neutral,0.6676744792886117,,0.30841417106582847,-1.05225,,-0.7989401194023041,,-0.925595059701152,,Neutral,,Neutral,,0.3535376143596057,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.2108,2.296,-7.861,-2.17465468819708,0.0105016354956487,Benign,0.7101,pathogenic,-3.35,available,https://doi.org/10.1101/2022.10.22.513328 +G112M,NP_000537:p.Gly112Met,,,,,saturation_mutlist,,,,,,,,0.10666,0.5472409009933472,,0.25306142568497986,,0.17986071284248994,,Neutral,Neutral,,Neutral,0.5591184791474325,,0.22006936492428816,-1.19537,,-0.4540635635871488,,-0.8247167817935744,,Neutral,,Neutral,,0.3067678128442426,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.2219,2.296,-22.1488,-3.57929652606347,0.1868941824370333,Benign,0.7509,pathogenic,-3.577,available,https://doi.org/10.1101/2022.10.22.513328 +G112N,NP_000537:p.Gly112Asn,,,,,saturation_mutlist,,,,,,,,1.0195,1.0105872774124145,,0.2128483415222191,,0.6161741707611096,,Neutral,Uncertain,,Neutral,0.4205729243213277,,0.16084415894681933,-0.31277,,-0.23187921501502576,,-0.27232460750751286,,Neutral,,Neutral,,0.10660025527804973,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.2325,2.296,-22.1488,-2.88514049624978,0.0230560628824044,Benign,0.5211,ambiguous,-3.154,available,https://doi.org/10.1101/2022.10.22.513328 +G112P,NP_000537:p.Gly112Pro,,,,,saturation_mutlist,,,,,,,,4.38601,2.570753812789917,,6.730372575646965,,5.558191287823482,,Destabilizing,Destabilizing,,Destabilizing,0.38711242188098266,,0.4793459753533816,3.09309,,5.5238785847285525,,4.308484292364277,,Destabilizing,,Destabilizing,,1.0595171062556605,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.3296,2.296,-22.1488,-5.02558159316508,0.4318180680706053,Uncertain,0.9818,pathogenic,-3.762,available,https://doi.org/10.1101/2022.10.22.513328 +G112Q,NP_000537:p.Gly112Gln,,,,,saturation_mutlist,,,,,,,,0.90995,0.7332496213912963,,0.5602219267759384,,0.7350859633879692,,Neutral,Neutral,,Neutral,0.5261497492562132,,0.17957457645465563,-0.3668,,0.036568236482572396,,-0.1651158817587138,,Neutral,,Neutral,,0.27757115134088955,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.1574,2.296,-6.8611,-1.84916558188363,0.0007626764636442,Benign,0.4666,ambiguous,-3.201,available,https://doi.org/10.1101/2022.10.22.513328 +G112R,NP_000537:p.Gly112Arg,"hg19,17:g.7579353C>G",,,,"cBioPortal,saturation_mutlist",,,,,,,,0.67663,0.5578165483474732,0.033900000000000007,0.17695188686031074,0.355265,0.42679094343015533,Neutral,Neutral,Neutral,Neutral,Neutral,0.7142653381240384,0.43177888114172513,0.1945542849051006,-0.3888,1.6373000000000004,-0.46184747252455655,0.6242500000000002,-0.42532373626227826,Neutral,Neutral,Neutral,Neutral,2.475429745276565,0.2654744192488619,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.151,2.296,-3.0537,-1.653371145859,4.8060033505685386e-05,Benign,0.5622,ambiguous,-3.004,available,https://doi.org/10.1101/2022.10.22.513328 +G112S,NP_000537:p.Gly112Ser,"hg19,17:g.7579353C>T, hg38,17:g.7676035C>T",,3.9798777382e-06,,"COSMIC,ClinVar,saturation_mutlist",492575,Conflicting classifications of pathogenicity,1,,,,,0.97124,0.7010054445266723,0.01621333333333334,0.8637550292307247,0.49372666666666665,0.9174975146153623,Neutral,Neutral,Neutral,Neutral,Neutral,0.44876516626833524,0.2065334297933926,0.22282100110455108,-0.16642,0.7227899999999999,0.4536857862571145,0.27818499999999996,0.14363289312855723,Neutral,Neutral,Neutral,Neutral,1.1713528611254027,0.21435486636433956,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.0705,2.296,-1.1129,0.334341221521181,0.0001093374070058,Benign,0.1593,benign,-3.016,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G112T,NP_000537:p.Gly112Thr,,,,,saturation_mutlist,,,,,,,,1.86348,1.0442052459716797,,1.2205675839837162,,1.5420237919918582,,Neutral,Uncertain,,Neutral,0.5460015171819693,,0.305622031206115,0.24293,,0.3275721652539941,,0.28525108262699705,,Neutral,,Neutral,,0.38364165389660837,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.1555,2.296,-2.6912,-1.2332696351093,0.0065021426021602,Benign,0.3364,benign,-3.16,available,https://doi.org/10.1101/2022.10.22.513328 +G112V,NP_000537:p.Gly112Val,,,,,saturation_mutlist,,,,,,,,1.38366,0.8883360171318054,,1.103951391731141,,1.2438056958655705,,Neutral,Neutral,,Neutral,0.7136085164914476,,0.267373264690066,0.00903,,-0.04687915793356501,,-0.018924578966782506,,Neutral,,Neutral,,0.44488907845412784,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.1777,2.296,-6.2761,-1.89898999348958,0.0008182552398676,Benign,0.5033,ambiguous,-3.14,available,https://doi.org/10.1101/2022.10.22.513328 +G112W,NP_000537:p.Gly112Trp,,,,,saturation_mutlist,,,,,,,,0.50266,0.8590637290477753,,-0.27096240328586263,,0.11584879835706868,,Neutral,Neutral,,Neutral,0.5243543675493151,,0.2216136610120532,-0.36302,,-1.0560315302472107,,-0.7095257651236053,,Neutral,,Neutral,,0.3195378328407655,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.2696,2.296,-22.1488,-4.05326500530896,0.482051244244269,Uncertain,0.8065,pathogenic,-3.776,available,https://doi.org/10.1101/2022.10.22.513328 +G112Y,NP_000537:p.Gly112Tyr,,,,,saturation_mutlist,,,,,,,,0.36763,0.840191912651062,,0.16510082913108012,,0.2663654145655401,,Neutral,Neutral,,Neutral,0.5787329439361774,,0.13428938959321296,-0.80726,,-0.5237341601950577,,-0.6654970800975288,,Neutral,,Neutral,,0.3402266973215577,16.098,6.56,57.365,15.775,,False,16.098,,neutral,neutral,neutral,,False,57.365,,neutral,neutral,neutral,uncertain,,-0.2702,2.296,-22.1488,-3.29481640589807,0.196935547244575,Benign,0.755,pathogenic,-3.519,available,https://doi.org/10.1101/2022.10.22.513328 +F113A,NP_000537:p.Phe113Ala,,,,,saturation_mutlist,,,,,,,,4.28494,1.7748886370658874,,3.463076721131365,,3.874008360565682,,Destabilizing,Uncertain,,Destabilizing,0.6758381687784358,,0.18403532547330398,-1.01982,,2.806267446414344,,0.8932237232071719,,Uncertain,,Neutral,,0.5589872496208148,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.4468,0.0223,-22.1457,-6.13349417321062,0.8703769787118026,Pathogenic,0.9963,pathogenic,-4.258,available,https://doi.org/10.1101/2022.10.22.513328 +F113C,NP_000537:p.Phe113Cys,"hg19,17:g.7579349A>C, hg19,17:g.7676031A>C, hg38,17:g.7676030_7676031delinsAC, hg38,17:g.7676031A>C",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634690,Pathogenic,1,,,,,3.67206,0.8110897874832154,3.635146666666667,3.586983331264866,3.6536033333333338,3.629521665632433,Destabilizing,Destabilizing,Neutral,Destabilizing,Destabilizing,0.45527875218703645,0.809003408576805,0.16474047898999156,-1.34734,2.475963333333333,3.1059549358732075,0.5643116666666665,0.8793074679366037,Uncertain,Uncertain,Neutral,Neutral,0.6519076650535377,0.40740328363042727,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.4149,0.0223,-22.1457,-5.3182039737857,0.354722584704024,Uncertain,0.9677,pathogenic,-3.968,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113D,NP_000537:p.Phe113Asp,,,,,saturation_mutlist,,,,,,,,4.87837,2.4314018630981447,,4.501733644541354,,4.690051822270677,,Destabilizing,Destabilizing,,Destabilizing,0.6109980622295008,,0.25865954286765513,0.79257,,4.069228054349406,,2.4308990271747026,,Uncertain,,Uncertain,,0.603302709441758,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.5697,0.0223,-22.1457,-7.21795550754685,0.8702116174010466,Pathogenic,0.9985,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +F113E,NP_000537:p.Phe113Glu,,,,,saturation_mutlist,,,,,,,,4.22134,2.1760254430770876,,4.187463988688603,,4.204401994344302,,Destabilizing,Destabilizing,,Destabilizing,0.5754731744022664,,0.2552418357524104,0.9223,,3.6657919043955745,,2.2940459521977874,,Uncertain,,Uncertain,,0.7542927183838455,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.5391,0.0223,-22.1457,-7.21795550754685,0.869092078893722,Pathogenic,0.9989,pathogenic,-4.374,available,https://doi.org/10.1101/2022.10.22.513328 +F113G,NP_000537:p.Phe113Gly,"hg19,17:g.7579349_7579350delinsCC",,,,"cBioPortal,saturation_mutlist",,,,,,,,5.20406,2.062308807373047,4.86882,5.077688357365515,5.036440000000001,5.140874178682758,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.5479179184144315,0.9926235208778804,0.16921615103786888,-0.57622,3.377776666666667,4.334133958487581,1.4007783333333337,1.8789569792437906,Uncertain,Uncertain,Neutral,Neutral,1.5046587365542028,0.3722620569826828,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.4821,0.0223,-22.1457,-7.21795550754685,0.8666329317367638,Pathogenic,0.9967,pathogenic,-4.458,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113H,NP_000537:p.Phe113His,,,,,saturation_mutlist,,,,,,,,2.83369,1.6783056378364563,,2.1762207353885237,,2.5049553676942615,,Uncertain,Uncertain,,Uncertain,0.4993723286419011,,0.0447408112008386,0.51117,,1.888010704490301,,1.1995903522451505,,Neutral,,Neutral,,0.19241581495725749,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.4743,0.0223,-22.1457,-4.35311958943548,0.8533267010813845,Pathogenic,0.9927,pathogenic,-4.273,available,https://doi.org/10.1101/2022.10.22.513328 +F113I,NP_000537:p.Phe113Ile,"hg19,17:g.7579350A>T, hg38,17:g.7676032A>T",,,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1469551,Pathogenic/Likely pathogenic,2,,,,,2.87156,0.6606433367729188,4.268820000000001,2.0493091855044763,3.57019,2.460434592752238,Uncertain,Uncertain,Neutral,Destabilizing,Uncertain,0.8168322902109796,1.7538153568339705,0.34686654182762355,-1.28772,1.6562366666666666,2.049867566500397,0.1842583333333333,0.3810737832501986,Neutral,Uncertain,Neutral,Neutral,0.9323168462253353,0.4775779934263766,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.3907,0.0223,-22.1457,-4.62039939052872,0.3471698875702665,Uncertain,0.9262,pathogenic,-3.762,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113K,NP_000537:p.Phe113Lys,,,,,saturation_mutlist,,,,,,,,3.78874,1.8474937319755553,,4.1883680818151126,,3.988554040907556,,Destabilizing,Uncertain,,Destabilizing,0.5057973616432911,,0.22155003195700754,1.06124,,3.479618005860901,,2.2704290029304506,,Uncertain,,Uncertain,,0.7692017247932833,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.546,0.0223,-22.1457,-7.21795550754685,0.865669254264934,Pathogenic,0.9988,pathogenic,-4.457,available,https://doi.org/10.1101/2022.10.22.513328 +F113L,NP_000537:p.Phe113Leu,"hg19,17:g.7579348G>C, hg19,17:g.7579348G>T, hg19,17:g.7579350A>G, hg19,17:g.7676030G>C, hg19,17:g.7676032A>G, hg38,17:g.7676030G>C, hg38,17:g.7676030G>T, hg38,17:g.7676032A>G",,,0.783,"cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","3634432, 2702402, 2125367","Pathogenic, Pathogenic, Likely pathogenic","1, 1, 1",,,,,2.03432,0.7719958114624024,3.0096366666666667,1.603806771507533,2.521978333333333,1.8190633857537666,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.5270396514499583,0.30267065713228436,0.18122371472167126,-1.81861,1.4363933333333332,1.5948633147308893,-0.19110833333333344,-0.1118733426345554,Neutral,Neutral,Neutral,Neutral,0.637259312594872,0.4830566428970151,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.3528,0.0223,-22.1457,-4.5916909414059,0.0721449101098672,Benign,0.9964,pathogenic,-3.566,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113M,NP_000537:p.Phe113Met,,,,,saturation_mutlist,,,,,,,,0.96919,0.942539565563202,,1.9106027194451396,,1.4398963597225698,,Neutral,Neutral,,Neutral,0.48730420013011244,,0.13610370990563708,-2.13962,,1.8870640009881638,,-0.126277999505918,,Uncertain,,Neutral,,0.4362560453998885,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.3838,0.0223,-22.1457,-4.43205180315152,0.6727790722939497,Uncertain,0.9767,pathogenic,-3.973,available,https://doi.org/10.1101/2022.10.22.513328 +F113N,NP_000537:p.Phe113Asn,,,,,saturation_mutlist,,,,,,,,3.86216,2.068465747833252,,3.186869056048582,,3.524514528024291,,Destabilizing,Destabilizing,,Destabilizing,0.48639207298610654,,0.2531250761083458,-0.25497,,2.948994579573594,,1.3470122897867969,,Uncertain,,Neutral,,0.4961768028345025,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.4994,0.0223,-22.1457,-7.21795550754685,0.8689550152710639,Pathogenic,0.9951,pathogenic,-4.398,available,https://doi.org/10.1101/2022.10.22.513328 +F113P,NP_000537:p.Phe113Pro,"hg19,17:g.7579348_7579350delinsAGG, hg38,17:g.7676030_7676032delinsAGG",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,5.15957,1.8437998175621033,5.184236666666666,6.010821904677936,5.171903333333333,5.585195952338968,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.5274300179841048,1.7663375502497312,0.6971373271267777,-0.57084,5.34898,6.5521571925723805,2.3890700000000002,2.99065859628619,Uncertain,Uncertain,Uncertain,Uncertain,2.6007678069882876,0.589190824135036,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.5701,0.0223,-22.1457,-7.21795550754685,0.8340828889646085,Pathogenic,0.9993,pathogenic,-4.192,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113Q,NP_000537:p.Phe113Gln,,,,,saturation_mutlist,,,,,,,,3.68625,2.0156846046447754,,3.2400795032688197,,3.4631647516344097,,Destabilizing,Destabilizing,,Destabilizing,0.5906932246218995,,0.2083380018501498,0.4558,,3.0213227861951637,,1.7385613930975818,,Uncertain,,Neutral,,0.5599196641413181,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.5015,0.0223,-22.1457,-7.21795550754685,0.862445849618718,Pathogenic,0.9976,pathogenic,-4.157,available,https://doi.org/10.1101/2022.10.22.513328 +F113R,NP_000537:p.Phe113Arg,,,,,saturation_mutlist,,,,,,,,4.19411,1.8280096960067749,,3.3307542422934966,,3.762432121146748,,Destabilizing,Uncertain,,Destabilizing,0.44089303209154124,,0.1640456424697781,4.19205,,2.661406817476872,,3.4267284087384358,,Uncertain,,Destabilizing,,0.6836012691653007,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.5474,0.0223,-22.1457,-7.21795550754685,0.8681372247955081,Pathogenic,0.9966,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328 +F113S,NP_000537:p.Phe113Ser,"hg19,17:g.7579349A>G, hg19,17:g.7676031A>G, hg38,17:g.7676031A>G",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",823709,Conflicting classifications of pathogenicity,1,,,,,4.68659,1.867291934490204,4.009523333333334,4.0960700905169105,4.3480566666666665,4.391330045258455,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.576252633762912,0.7040752740218115,0.26786233676260995,-0.54105,2.9341266666666663,3.529885500039722,1.1965383333333333,1.4944177500198608,Uncertain,Uncertain,Neutral,Neutral,1.3621986824330077,0.47933787679712975,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.4258,0.0223,-22.1457,-6.13349417321062,0.8695796678637897,Pathogenic,0.9952,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113T,NP_000537:p.Phe113Thr,,,,,saturation_mutlist,,,,,,,,4.00506,1.703507926464081,,3.387805815381047,,3.6964329076905234,,Destabilizing,Uncertain,,Destabilizing,0.6639235862085254,,0.26766953989061465,-0.61555,,2.961549939778235,,1.1729999698891174,,Uncertain,,Neutral,,0.4941246211222308,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.472,0.0223,-22.1457,-6.13349417321062,0.8597742127206307,Pathogenic,0.9968,pathogenic,-4.306,available,https://doi.org/10.1101/2022.10.22.513328 +F113V,NP_000537:p.Phe113Val,"hg19,17:g.7579350A>C, hg19,17:g.7676032A>C, hg38,17:g.7676032A>C",,,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141302,Conflicting classifications of pathogenicity,1,,,,,3.24652,0.9389445018768311,3.07381,2.4389003508898224,3.160165,2.8427101754449113,Destabilizing,Uncertain,Neutral,Destabilizing,Uncertain,0.7748425609025046,1.456737494609101,0.37610028560965686,-1.69667,2.16939,2.150152586967908,0.23636000000000001,0.226741293483954,Uncertain,Uncertain,Neutral,Neutral,1.2231970906058707,0.545865998880993,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.385,0.0223,-22.1457,-5.04973460316859,0.2938139973777304,Benign,0.9446,pathogenic,-3.778,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113W,NP_000537:p.Phe113Trp,,,,,saturation_mutlist,,,,,,,,1.29899,0.6575628972053528,,0.9637481310389447,,1.1313690655194724,,Neutral,Neutral,,Neutral,0.4964159447193548,,0.3238523568860114,6.44386,,0.5590595103821134,,3.501459755191057,,Uncertain,,Destabilizing,,0.15041523227914946,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,damaging,,-0.3025,0.0223,-8.8578,-2.6540479440965,0.6412423681462546,Uncertain,0.9397,pathogenic,-4.053,available,https://doi.org/10.1101/2022.10.22.513328 +F113Y,NP_000537:p.Phe113Tyr,,,,,saturation_mutlist,,,,,,,,1.24679,0.7248794865608216,,0.9976664499098559,,1.122228224954928,,Neutral,Neutral,,Neutral,0.40309601652109533,,0.18010717125743933,2.79388,,0.6262681897358412,,1.7100740948679207,,Uncertain,,Neutral,,0.31289595556826133,25.101,6.733,4.055,8.69,,False,25.101,,neutral,neutral,neutral,,False,4.055,,neutral,neutral,neutral,uncertain,,-0.3386,0.0223,-22.1457,-4.23850217988098,0.8305176799224958,Pathogenic,0.8085,pathogenic,-3.79,available,https://doi.org/10.1101/2022.10.22.513328 +L114A,NP_000537:p.Leu114Ala,,,,,saturation_mutlist,,,,,,,,0.85406,0.26733574390411374,,1.9332879849797981,,1.393673992489899,,Neutral,Neutral,,Neutral,0.1863055569606183,,0.449199939786271,0.12528,,0.7588808724042099,,0.4420804362021049,,Neutral,,Neutral,,0.2392504472676858,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.3061,1.2277,-22.1457,-3.02147339813199,0.0922607492949681,Benign,0.4215,ambiguous,-3.444,available,https://doi.org/10.1101/2022.10.22.513328 +L114C,NP_000537:p.Leu114Cys,,,,,saturation_mutlist,,,,,,,,0.75335,-0.038175895214080796,,2.168237659339297,,1.4607938296696483,,Uncertain,Neutral,,Neutral,0.1365468043693986,,0.14867666040342592,0.13014,,1.1155389453721807,,0.6228394726860903,,Neutral,,Neutral,,0.16992394576748968,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.2953,1.2277,-22.1457,-3.61918334445075,0.4377881291385662,Uncertain,0.6481,pathogenic,-3.647,available,https://doi.org/10.1101/2022.10.22.513328 +L114D,NP_000537:p.Leu114Asp,,,,,saturation_mutlist,,,,,,,,0.76564,0.41866341829299925,,2.3722027106451065,,1.5689213553225532,,Uncertain,Neutral,,Neutral,0.41283520825651393,,0.5523013070451457,-0.25873,,0.3426639006990014,,0.04196695034950068,,Neutral,,Neutral,,0.39963145210170203,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.4276,1.2277,-22.1457,-2.31518817363431,0.0651642286155228,Benign,0.8617,pathogenic,-3.4,available,https://doi.org/10.1101/2022.10.22.513328 +L114E,NP_000537:p.Leu114Glu,,,,,saturation_mutlist,,,,,,,,0.58486,0.3441263473033905,,1.9708728290109283,,1.2778664145054641,,Neutral,Neutral,,Neutral,0.2680928193506643,,0.4732059012610794,-0.01329,,0.38008607607881845,,0.1833980380394092,,Neutral,,Neutral,,0.27212182265667106,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.3117,1.2277,-5.688,-1.38574124110082,0.0002346572355485,Benign,0.5565,ambiguous,-3.014,available,https://doi.org/10.1101/2022.10.22.513328 +L114F,NP_000537:p.Leu114Phe,"hg19,17:g.7579345C>A, hg19,17:g.7579345C>G, hg38,17:g.7676027C>A",,3.980986807e-06,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.42358,0.14790383815765376,0.34558,0.8976743821728652,0.38458000000000003,0.6606271910864326,Neutral,Neutral,Neutral,Neutral,Neutral,0.2439743952346726,0.5688065222903127,0.26184577520507957,0.05708,0.47834666666666664,0.16733608795547836,0.2677133333333333,0.11220804397773917,Neutral,Neutral,Neutral,Neutral,0.2053978439246354,0.03469113790523629,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.2395,1.2277,-22.1457,-4.11368345820104,0.557200039113269,Uncertain,0.2723,benign,-3.771,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L114G,NP_000537:p.Leu114Gly,,,,,saturation_mutlist,,,,,,,,1.34595,0.8155127370357513,,3.1524157115776905,,2.2491828557888454,,Uncertain,Neutral,,Uncertain,0.37422142725101987,,0.685300816633144,0.19945,,0.9629843110593499,,0.5812171555296749,,Neutral,,Neutral,,0.46017206019520873,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.3809,1.2277,-22.1457,-3.69591548065688,0.0404722366865803,Benign,0.6798,pathogenic,-3.37,available,https://doi.org/10.1101/2022.10.22.513328 +L114H,NP_000537:p.Leu114His,,,,,saturation_mutlist,,,,,,,,1.16765,0.2261746668815613,,1.4728863065359576,,1.3202681532679788,,Neutral,Neutral,,Neutral,0.23587027870731472,,0.44040644704092563,0.10997,,0.12775430730849394,,0.11886215365424696,,Neutral,,Neutral,,0.1811486635883795,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.2726,1.2277,-7.273,-2.79011641652625,0.0036799364687273,Benign,0.3797,ambiguous,-3.302,available,https://doi.org/10.1101/2022.10.22.513328 +L114I,NP_000537:p.Leu114Ile,,,,,saturation_mutlist,,,,,,,,0.39042,-0.23848891258239746,,0.7461581215507596,,0.5682890607753798,,Neutral,Neutral,,Neutral,0.2858426572191347,,0.20959124576419846,0.62851,,0.6032119921841473,,0.6158609960920737,,Neutral,,Neutral,,0.6042460250528249,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.1124,1.2277,-8.8578,-0.345807039189694,0.1959178756992446,Benign,0.1441,benign,-3.488,available,https://doi.org/10.1101/2022.10.22.513328 +L114K,NP_000537:p.Leu114Lys,,,,,saturation_mutlist,,,,,,,,0.20635,0.1534431505203247,,1.8644067939509228,,1.0353783969754613,,Neutral,Neutral,,Neutral,0.12103216721143412,,0.5627635586270335,-0.14515,,0.29904219784016606,,0.07694609892008303,,Neutral,,Neutral,,0.3168905503955622,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.3947,1.2277,-22.1457,-3.01079486307124,0.002740076722145,Benign,0.5153,ambiguous,-3.454,available,https://doi.org/10.1101/2022.10.22.513328 +L114M,NP_000537:p.Leu114Met,,,,,saturation_mutlist,,,,,,,,-0.03643,0.12743960618972774,,1.0359381286304108,,0.4997540643152054,,Neutral,Neutral,,Neutral,0.064710919773702,,0.16445817121781875,-0.07364,,0.279496536686971,,0.10292826834348551,,Neutral,,Neutral,,0.07345819267733505,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.2035,1.2277,-22.1457,-3.63992464586932,0.5701816960720417,Uncertain,0.1838,benign,-3.63,available,https://doi.org/10.1101/2022.10.22.513328 +L114N,NP_000537:p.Leu114Asn,,,,,saturation_mutlist,,,,,,,,0.87214,0.32786606550216674,,1.8240252081717856,,1.3480826040858929,,Neutral,Neutral,,Neutral,0.2571900118459851,,0.3158829176837563,-0.09266,,0.22778415447458955,,0.06756207723729477,,Neutral,,Neutral,,0.31246978567873496,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.2918,1.2277,-6.0506,-1.37982099473904,0.0013152254315917,Benign,0.5681,pathogenic,-3.278,available,https://doi.org/10.1101/2022.10.22.513328 +L114P,NP_000537:p.Leu114Pro,,,,,saturation_mutlist,,,,,,,,0.37799,1.2913168120384215,,3.6193825355377314,,1.9986862677688657,,Uncertain,Uncertain,,Neutral,0.899829318870584,,0.9953097555252387,1.58397,,4.076080526104962,,2.830025263052481,,Uncertain,,Uncertain,,1.4248250073426174,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.304,1.2277,-5.3985,-2.05794352549244,0.0002029865377321,Benign,0.3056,benign,-3.202,available,https://doi.org/10.1101/2022.10.22.513328 +L114Q,NP_000537:p.Leu114Gln,,,,,saturation_mutlist,,,,,,,,0.6024,0.22682250022888184,,1.6966459137378742,,1.1495229568689371,,Neutral,Neutral,,Neutral,0.1467170926656441,,0.2570776210146592,-0.0191,,0.5581359036938341,,0.26951795184691707,,Neutral,,Neutral,,0.20445400090047877,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.216,1.2277,-0.4234,-0.963111150646381,3.340247947338193e-07,Benign,0.2211,benign,-2.894,available,https://doi.org/10.1101/2022.10.22.513328 +L114R,NP_000537:p.Leu114Arg,,,,,saturation_mutlist,,,,,,,,0.40469,0.0541316282749176,,1.4077164703565999,,0.9062032351782999,,Neutral,Neutral,,Neutral,0.16326009268983058,,0.36868403049366694,-0.0856,,0.13615329776799315,,0.025276648883996576,,Neutral,,Neutral,,0.20724209985298578,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.3185,1.2277,-8.8578,-2.51852481255318,0.0044504030389418,Benign,0.3325,benign,-3.324,available,https://doi.org/10.1101/2022.10.22.513328 +L114S,NP_000537:p.Leu114Ser,"hg19,17:g.7579346A>G, hg38,17:g.7676028A>G",,3.9802896059e-06,,"ClinVar,saturation_mutlist",458536,Conflicting classifications of pathogenicity,1,,,,,1.19405,0.20541178345680236,1.1931966666666665,2.290430916273014,1.1936233333333333,1.7422404581365072,Neutral,Uncertain,Neutral,Neutral,Neutral,0.22756371602131614,0.4817716605982086,0.5444885481260643,0.01258,0.5776633333333333,0.6825154805755983,0.29512166666666667,0.34754774028779917,Neutral,Neutral,Neutral,Neutral,0.5156891505764128,0.22132688300866277,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.3365,1.2277,-22.1457,-3.11324781431236,0.0209766339057478,Benign,0.4267,ambiguous,-3.336,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L114T,NP_000537:p.Leu114Thr,,,,,saturation_mutlist,,,,,,,,1.16334,0.08337893724441528,,1.8402276754569626,,1.5017838377284813,,Neutral,Neutral,,Neutral,0.20240232700455094,,0.3454215536152088,0.31439,,0.7914553911035395,,0.5529226955517698,,Neutral,,Neutral,,0.2356838751947346,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.2363,1.2277,-7.8579,-2.29240328586287,0.0030058673369745,Benign,0.375,ambiguous,-3.283,available,https://doi.org/10.1101/2022.10.22.513328 +L114V,NP_000537:p.Leu114Val,"hg19,17:g.7579347A>C, hg38,17:g.7676029A>C",,,0.573,"ClinVar,saturation_mutlist",1011474,Uncertain significance,1,,,,,0.67211,-0.1556653141975403,0.2709766666666667,0.9135428274226279,0.4715433333333333,0.7928264137113139,Neutral,Neutral,Neutral,Neutral,Neutral,0.2565394658171657,0.4056883645799514,0.14055517464506428,0.69911,0.71032,0.6290965146335729,0.704715,0.6641032573167864,Neutral,Neutral,Neutral,Neutral,1.3544080331519992,0.5017858389731835,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.1487,1.2277,-8.8578,-2.82763989652406,0.1547529500998032,Benign,0.1575,benign,-3.364,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L114W,NP_000537:p.Leu114Trp,,,,,saturation_mutlist,,,,,,,,0.65264,0.16311667680740358,,0.746494186944295,,0.6995670934721475,,Neutral,Neutral,,Neutral,0.2780404610761238,,0.47591135345541574,0.24556,,-0.0786459266025783,,0.08345703669871085,,Neutral,,Neutral,,0.0630357670384797,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.3387,1.2277,-22.1457,-4.46690504695434,0.5531482661432023,Uncertain,0.4845,ambiguous,-3.851,available,https://doi.org/10.1101/2022.10.22.513328 +L114Y,NP_000537:p.Leu114Tyr,,,,,saturation_mutlist,,,,,,,,0.60217,0.13998995780944823,,1.1533278398827205,,0.8777489199413602,,Neutral,Neutral,,Neutral,0.2725065545637488,,0.37822732669503917,0.12383,,0.23331655944286803,,0.178573279721434,,Neutral,,Neutral,,0.07169751565633435,45.06,10.968,79.985,9.243,,False,45.06,,neutral,neutral,neutral,,False,79.985,,neutral,neutral,neutral,uncertain,,-0.3316,1.2277,-22.1457,-4.26309926818903,0.4611170891989466,Uncertain,0.6318,pathogenic,-3.658,available,https://doi.org/10.1101/2022.10.22.513328 +H115A,NP_000537:p.His115Ala,,,,,saturation_mutlist,,,,,,,,0.47431,0.26614645957946775,,1.3819328353704285,,0.9281214176852143,,Neutral,Neutral,,Neutral,0.27533337372597744,,0.6642151070264938,-0.31995,,0.5519967981355904,,0.11602339906779521,,Neutral,,Neutral,,0.004109824529043345,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.1125,1.2631,-8.8578,-2.49871178402455,0.0003245250112844,Benign,0.1469,benign,-3.114,available,https://doi.org/10.1101/2022.10.22.513328 +H115C,NP_000537:p.His115Cys,,,,,saturation_mutlist,,,,,,,,0.25416,-0.10294482707977295,,1.6642563011754072,,0.9592081505877036,,Neutral,Neutral,,Neutral,0.21276207282012313,,0.5272224442339234,-0.40891,,1.0117477738224794,,0.3014188869112397,,Neutral,,Neutral,,0.03863164975583228,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.2349,1.2631,-22.1457,-3.74325866775051,0.0018230464683667,Benign,0.1408,benign,-3.384,available,https://doi.org/10.1101/2022.10.22.513328 +H115D,NP_000537:p.His115Asp,,,,,saturation_mutlist,,,,,,,,0.14683,0.34107786178588867,,1.6052076365180825,,0.8760188182590413,,Neutral,Neutral,,Neutral,0.5555624475254293,,0.9615675342254082,-0.3022,,0.504085174768148,,0.10094258738407397,,Neutral,,Neutral,,0.02239527600534891,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.2276,1.2631,-22.1457,-1.40673083084263,2.887410857536157e-06,Benign,0.1065,benign,-3.056,available,https://doi.org/10.1101/2022.10.22.513328 +H115E,NP_000537:p.His115Glu,,,,,saturation_mutlist,,,,,,,,0.15806,0.37861911177635194,,1.410510412970751,,0.7842852064853756,,Neutral,Neutral,,Neutral,0.4368078510927122,,0.9842142328621866,-0.26108,,0.39892177507592014,,0.06892088753796008,,Neutral,,Neutral,,0.08769608647701888,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.1632,1.2631,-7.273,-0.909469237543317,9.00066842915454e-08,Benign,0.1491,benign,-2.845,available,https://doi.org/10.1101/2022.10.22.513328 +H115F,NP_000537:p.His115Phe,,,,,saturation_mutlist,,,,,,,,-0.73871,0.25699786901474,,-0.45665700890909217,,-0.5976835044545461,,Neutral,Neutral,,Neutral,0.22586132081692897,,0.2127065374693179,-0.39143,,-0.051851305944903836,,-0.22164065297245192,,Neutral,,Neutral,,0.3654535910912233,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.202,1.2631,-22.1457,-3.60121260300351,0.0029691475110697,Benign,0.3412,ambiguous,-3.498,available,https://doi.org/10.1101/2022.10.22.513328 +H115G,NP_000537:p.His115Gly,,,,,saturation_mutlist,,,,,,,,0.67929,0.706191998720169,,2.309391744491951,,1.4943408722459754,,Uncertain,Neutral,,Neutral,0.4184025672828372,,0.9100301839794541,-0.69826,,1.2684658754322047,,0.28510293771610234,,Neutral,,Neutral,,0.29190483263361383,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.2629,1.2631,-22.1457,-4.25156140938952,0.0007022105094633,Benign,0.1632,benign,-3.181,available,https://doi.org/10.1101/2022.10.22.513328 +H115I,NP_000537:p.His115Ile,,,,,saturation_mutlist,,,,,,,,0.80182,0.3312854635715485,,0.6672151737435555,,0.7345175868717777,,Neutral,Neutral,,Neutral,0.37135083407700487,,0.5606674430549184,0.74932,,-0.018833760044688248,,0.36524311997765585,,Neutral,,Neutral,,0.29847349747193297,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.1988,1.2631,-8.8578,-3.21877729587408,0.0060322700694805,Benign,0.2678,benign,-3.524,available,https://doi.org/10.1101/2022.10.22.513328 +H115K,NP_000537:p.His115Lys,,,,,saturation_mutlist,,,,,,,,-0.09138,0.6665080833435059,,1.3580267631525704,,0.6333233815762852,,Neutral,Neutral,,Neutral,0.5289777489761663,,0.7889179740238955,-0.76468,,0.49691274878842906,,-0.13388362560578548,,Neutral,,Neutral,,0.10984173941812284,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.128,1.2631,-3.4657,-0.71613825039974,3.875358886704338e-08,Benign,0.14,benign,-2.916,available,https://doi.org/10.1101/2022.10.22.513328 +H115L,NP_000537:p.His115Leu,,,,,saturation_mutlist,,,,,,,,-0.10079,0.4322673749923706,,0.3115979437989808,,0.10540397189949041,,Neutral,Neutral,,Neutral,0.39447653890462453,,0.3453316362211244,-0.86817,,-0.37158819359745077,,-0.6198790967987253,,Neutral,,Neutral,,0.258719746255018,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.2302,1.2631,-22.1457,-4.8353305868595,0.0083582120182901,Benign,0.1167,benign,-3.47,available,https://doi.org/10.1101/2022.10.22.513328 +H115M,NP_000537:p.His115Met,,,,,saturation_mutlist,,,,,,,,-0.51143,0.35132079482078554,,0.666190922157886,,0.07738046107894297,,Neutral,Neutral,,Neutral,0.309839863128265,,0.40264892845179995,-1.14474,,0.029383870431111857,,-0.5576780647844441,,Neutral,,Neutral,,0.17808284633023108,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.1803,1.2631,-22.1457,-4.8353305868595,0.0437260673551567,Benign,0.363,ambiguous,-3.534,available,https://doi.org/10.1101/2022.10.22.513328 +H115N,NP_000537:p.His115Asn,"hg19,17:g.7579344G>T, hg38,17:g.7676026G>T",,,,"ClinVar,saturation_mutlist",480741,Conflicting classifications of pathogenicity,1,,,,,-0.02441,0.268150646686554,0.39818666666666663,1.125117712002757,0.18688833333333332,0.5503538560013784,Neutral,Neutral,Neutral,Neutral,Neutral,0.4216270605143645,0.48036023165490666,0.6168290579190504,-0.29993,0.23140666666666668,0.324301665024207,-0.03426166666666665,0.012185832512103506,Neutral,Neutral,Neutral,Neutral,0.9571375433842074,0.01427719624492858,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.0998,1.2631,-5.0506,0.308822816233988,5.974850187780796e-08,Benign,0.059,benign,-2.824,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H115P,NP_000537:p.His115Pro,,,,,saturation_mutlist,,,,,,,,1.68632,0.9983009839057922,,3.412501377634096,,2.549410688817048,,Uncertain,Neutral,,Uncertain,0.5985363735938845,,2.004597375777304,2.64556,,5.15296339928869,,3.899261699644345,,Uncertain,,Destabilizing,,0.6071749101618601,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.2677,1.2631,-7.273,-2.13513398079854,7.85116973659687e-07,Benign,0.0802,benign,-2.95,available,https://doi.org/10.1101/2022.10.22.513328 +H115Q,NP_000537:p.His115Gln,,,,,saturation_mutlist,,,,,,,,0.09934,0.37482823491096495,,1.2715677396184741,,0.6854538698092371,,Neutral,Neutral,,Neutral,0.37422467829760536,,0.6739035402108069,-0.19483,,0.47925897117399474,,0.14221448558699737,,Neutral,,Neutral,,0.10030593064150363,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.0376,1.2631,-0.3945,0.28798040500391,1.1311714008605628e-15,Benign,0.0936,benign,-2.689,available,https://doi.org/10.1101/2022.10.22.513328 +H115R,NP_000537:p.His115Arg,"hg19,17:g.7579343T>C, hg38,17:g.7676025T>C",,,0.484,"ClinVar,saturation_mutlist",182925,Likely benign,3,,,,,0.11326,0.5914884495735169,0.7269833333333334,0.8890301887329407,0.4201216666666667,0.5011450943664704,Neutral,Neutral,Neutral,Neutral,Neutral,0.44368331058970784,0.46236451949613183,0.5926004199797159,-0.33911,0.5916100000000001,0.2037327274086255,0.12625000000000003,-0.06768863629568726,Neutral,Neutral,Neutral,Neutral,0.3451653710904383,0.16934974838499914,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.1489,1.2631,-8.8578,-0.639219997941988,0.0034631911295987,Benign,0.0837,benign,-3.186,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H115S,NP_000537:p.His115Ser,,,,,saturation_mutlist,,,,,,,,0.58866,0.12639066934585572,,1.6956290158675735,,1.1421445079337866,,Neutral,Neutral,,Neutral,0.40713589913588005,,0.9807786650892139,-0.36834,,0.8983381935786054,,0.2649990967893027,,Neutral,,Neutral,,0.08882381106765638,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.1863,1.2631,-22.1457,-3.02281899931621,6.736528986214677e-05,Benign,0.1089,benign,-3.01,available,https://doi.org/10.1101/2022.10.22.513328 +H115T,NP_000537:p.His115Thr,,,,,saturation_mutlist,,,,,,,,1.06088,0.22719268679618834,,1.3516504241711533,,1.2062652120855768,,Neutral,Neutral,,Neutral,0.3321919619790122,,0.8256050078100714,0.66295,,0.5813660277332147,,0.6221580138666074,,Neutral,,Neutral,,0.10702088745367379,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.1633,1.2631,-8.8578,-2.96321283812971,1.3846378687659026e-05,Benign,0.1342,benign,-3.031,available,https://doi.org/10.1101/2022.10.22.513328 +H115V,NP_000537:p.His115Val,,,,,saturation_mutlist,,,,,,,,0.89853,0.2801243829727173,,0.7640420116326493,,0.8312860058163247,,Neutral,Neutral,,Neutral,0.3065244354386547,,0.5263302900364495,0.57396,,0.11717328501397727,,0.34556664250698865,,Neutral,,Neutral,,0.23364556604570624,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.223,1.2631,-22.1457,-4.8353305868595,0.0027855934757054,Benign,0.1977,benign,-3.326,available,https://doi.org/10.1101/2022.10.22.513328 +H115W,NP_000537:p.His115Trp,,,,,saturation_mutlist,,,,,,,,-0.40439,0.1659415030479431,,-0.46752770144398137,,-0.4359588507219907,,Neutral,Neutral,,Neutral,0.24011898598752868,,0.010931996506715183,0.75496,,-0.2994014830243197,,0.22777925848784014,,Neutral,,Neutral,,0.3814611888365702,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.2182,1.2631,-22.1457,-3.60121260300351,0.0256810906046774,Benign,0.3966,ambiguous,-3.702,available,https://doi.org/10.1101/2022.10.22.513328 +H115Y,NP_000537:p.His115Tyr,"hg19,17:g.7579344G>A, hg38,17:g.7676026G>A",,,0.517,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.53453,0.11598168015480041,-0.7055566666666667,-0.34159679567383766,-0.6200433333333333,-0.43806339783691883,Neutral,Neutral,Neutral,Neutral,Neutral,0.2514284173534519,0.23112487279006172,0.19147035533291304,-0.21133,-0.18469333333333338,0.08090185143215829,-0.1980116666666667,-0.06521407428392084,Neutral,Neutral,Neutral,Neutral,0.2580502879070064,0.3193625467060461,50.964,23.091,46.325,14.27,,False,50.964,,neutral,neutral,neutral,,False,46.325,,neutral,neutral,neutral,uncertain,,-0.1522,1.2631,-22.1457,-3.31338370914593,0.0064119375148505,Benign,0.1234,benign,-3.38,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S116A,NP_000537:p.Ser116Ala,"hg19,17:g.7579341A>C, hg38,17:g.7676023A>C",,7.9620370075e-06,,"ClinVar,saturation_mutlist",649358,Conflicting classifications of pathogenicity,1,,,,,0.07697,0.20112225770950318,-0.003516666666666677,0.09796022859271779,0.03672666666666666,0.08746511429635889,Neutral,Neutral,Neutral,Neutral,Neutral,0.20287091170771648,0.6301199245293619,0.28306603332895475,0.46573,0.19558,-0.26139779665644564,0.330655,0.10216610167177717,Neutral,Neutral,Neutral,Neutral,0.2676134708866503,0.3248809608985668,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.1914,0.2264,-8.8578,-2.00341217169089,0.0413209143765034,Benign,0.1921,benign,-3.455,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S116C,NP_000537:p.Ser116Cys,"hg19,17:g.7579340G>C, hg38,17:g.7676022G>C",,,0.706,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.00361,0.008797378540039065,0.6839,0.538789475488223,0.343755,0.2711997377441115,Neutral,Neutral,Neutral,Neutral,Neutral,0.3040545890985059,0.5333608538941217,0.1788061121520238,0.27214,0.4579366666666667,0.33009888251225034,0.36503833333333335,0.30111944125612516,Neutral,Neutral,Neutral,Neutral,0.18130556533714626,0.2522307255186406,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.2419,0.2264,-8.8578,-2.45105725928614,0.3262575042509616,Uncertain,0.2552,benign,-3.764,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S116D,NP_000537:p.Ser116Asp,,,,,saturation_mutlist,,,,,,,,-0.2638,0.15211097240448,,0.10722247845054617,,-0.0782887607747269,,Neutral,Neutral,,Neutral,0.4237862842792432,,0.14847238522068942,-0.38733,,0.10117844163610275,,-0.14307577918194864,,Neutral,,Neutral,,0.10217208159872883,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.3579,0.2264,-22.1457,-4.51569896990287,0.363969222951413,Uncertain,0.9092,pathogenic,-3.652,available,https://doi.org/10.1101/2022.10.22.513328 +S116E,NP_000537:p.Ser116Glu,,,,,saturation_mutlist,,,,,,,,-0.40866,0.2725708758831024,,0.145669604690586,,-0.13149519765470702,,Neutral,Neutral,,Neutral,0.46017348018884896,,0.1886650626274634,0.26203,,0.001303888243481599,,0.1316669441217408,,Neutral,,Neutral,,0.16874165544469263,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.331,0.2264,-22.1457,-3.87953381312762,0.1612981074433769,Benign,0.9212,pathogenic,-3.553,available,https://doi.org/10.1101/2022.10.22.513328 +S116F,NP_000537:p.Ser116Phe,"hg19,17:g.7579340G>A, hg38,17:g.7676022G>A",,,0.728,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.17705,0.40166611075401304,-0.039909999999999946,-0.4384938356187915,-0.10847999999999998,-0.3077719178093958,Neutral,Neutral,Neutral,Neutral,Neutral,0.4730732118411203,0.7526935432609122,0.3027393716085485,0.41256,0.19059,-0.8488716831658291,0.301575,-0.21815584158291454,Neutral,Neutral,Neutral,Neutral,0.46455748628847504,0.3251467802305492,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.2643,0.2264,-7.8579,-4.33430097327344,0.0420031375207094,Benign,0.6667,pathogenic,-3.809,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S116G,NP_000537:p.Ser116Gly,,,,,saturation_mutlist,,,,,,,,0.31781,0.48916959404945376,,0.6731446735702474,,0.49547733678512373,,Neutral,Neutral,,Neutral,0.2932235329638852,,0.2493164129753601,-0.51315,,0.6868336951150225,,0.08684184755751123,,Neutral,,Neutral,,0.1598926413989151,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.2683,0.2264,-22.1457,-5.32337415423123,0.3883380802803214,Uncertain,0.2886,benign,-3.718,available,https://doi.org/10.1101/2022.10.22.513328 +S116H,NP_000537:p.Ser116His,,,,,saturation_mutlist,,,,,,,,0.34727,0.2997001695632935,,-0.35347177607585806,,-0.003100888037929017,,Neutral,Neutral,,Neutral,0.4689860243632873,,0.23437208376250346,0.64281,,-0.6347549584223999,,0.004027520788800032,,Neutral,,Neutral,,0.22666301074853276,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.3385,0.2264,-22.1457,-5.89550803007333,0.6801145930519357,Pathogenic,0.7848,pathogenic,-3.961,available,https://doi.org/10.1101/2022.10.22.513328 +S116I,NP_000537:p.Ser116Ile,,,,,saturation_mutlist,,,,,,,,-0.00168,0.4581688213348389,,-0.34332860657010816,,-0.1725043032850541,,Neutral,Neutral,,Neutral,0.46981150455423054,,0.46538829305150853,1.39929,,-0.3223563490933971,,0.5384668254533014,,Neutral,,Neutral,,0.40989827358324904,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.3404,0.2264,-22.1457,-6.12861430951413,0.8042692387320659,Pathogenic,0.7785,pathogenic,-4.162,available,https://doi.org/10.1101/2022.10.22.513328 +S116K,NP_000537:p.Ser116Lys,,,,,saturation_mutlist,,,,,,,,-0.43079,0.5114349365234375,,-0.0139512343533895,,-0.22237061717669476,,Neutral,Neutral,,Neutral,0.441854303231533,,0.08746664193797504,0.36986,,-0.07479210789505693,,0.14753394605247155,,Neutral,,Neutral,,0.2583788551013967,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.3478,0.2264,-22.1457,-5.47217201295152,0.4881810707830208,Uncertain,0.9772,pathogenic,-3.774,available,https://doi.org/10.1101/2022.10.22.513328 +S116L,NP_000537:p.Ser116Leu,,,,,saturation_mutlist,,,,,,,,-0.51782,0.44854249119758605,,-0.7384901113672008,,-0.6281550556836004,,Neutral,Neutral,,Neutral,0.46867164773900744,,0.39399582093741603,0.32949,,-0.8396581142753092,,-0.2550840571376546,,Neutral,,Neutral,,0.3423019887057928,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.3366,0.2264,-22.1457,-5.96281620325936,0.5155338775396696,Uncertain,0.4045,ambiguous,-3.915,available,https://doi.org/10.1101/2022.10.22.513328 +S116M,NP_000537:p.Ser116Met,,,,,saturation_mutlist,,,,,,,,-0.67493,0.3776670432090759,,-0.3657253694564975,,-0.5203276847282488,,Neutral,Neutral,,Neutral,0.3893388565398864,,0.3298005488634178,0.17933,,-0.48775365110939767,,-0.15421182555469884,,Neutral,,Neutral,,0.32085421716620555,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.3077,0.2264,-22.1457,-6.12861430951413,0.7829491194766001,Pathogenic,0.5745,pathogenic,-4.135,available,https://doi.org/10.1101/2022.10.22.513328 +S116N,NP_000537:p.Ser116Asn,,,,,saturation_mutlist,,,,,,,,0.13974,0.21729273080825806,,-0.18066116189425566,,-0.020460580947127827,,Neutral,Neutral,,Neutral,0.4268853402586752,,0.08458409831461625,0.18504,,-0.23950937527820249,,-0.027234687639101238,,Neutral,,Neutral,,0.13045940437229264,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.2056,0.2264,-7.273,-3.01068707742963,0.0001062729721008,Benign,0.6127,pathogenic,-3.449,available,https://doi.org/10.1101/2022.10.22.513328 +S116P,NP_000537:p.Ser116Pro,"hg38,17:g.7676023A>G",,,,"COSMIC,saturation_mutlist",,,,,,,,0.05403,0.7140417754650116,1.8577100000000002,1.8321267256090268,0.9558700000000001,0.9430783628045134,Neutral,Neutral,Neutral,Neutral,Neutral,0.5517493056478028,1.597644521224919,1.5386894619745703,2.27828,3.3786833333333335,3.87954633128221,2.828481666666667,3.0789131656411053,Uncertain,Uncertain,Uncertain,Destabilizing,1.1010065617222977,1.3302423844642468,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.4126,0.2264,-22.1457,-4.16912442701375,0.4106374427540816,Uncertain,0.693,pathogenic,-3.616,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S116Q,NP_000537:p.Ser116Gln,,,,,saturation_mutlist,,,,,,,,-0.20639,0.3202242588996887,,0.020471400694174025,,-0.09295929965291298,,Neutral,Neutral,,Neutral,0.407248456899163,,0.20316288483060058,0.39729,,-0.13568047128149424,,0.13080476435925287,,Neutral,,Neutral,,0.22876071738574577,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.3011,0.2264,-22.1457,-4.19479262125623,0.1434728875251132,Benign,0.8732,pathogenic,-3.675,available,https://doi.org/10.1101/2022.10.22.513328 +S116R,NP_000537:p.Ser116Arg,,,,,saturation_mutlist,,,,,,,,-0.33262,0.5354077625274658,,-0.3527891720267278,,-0.34270458601336395,,Neutral,Neutral,,Neutral,0.44367046666848964,,0.15684232131383277,0.38255,,-0.46309648632570677,,-0.040273243162853384,,Neutral,,Neutral,,0.26558045581646184,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.353,0.2264,-22.1457,-6.17290934307554,0.727033203104112,Pathogenic,0.9606,pathogenic,-3.909,available,https://doi.org/10.1101/2022.10.22.513328 +S116T,NP_000537:p.Ser116Thr,,,,,saturation_mutlist,,,,,,,,0.07987,0.23055584073066712,,0.028521021314130156,,0.05419551065706508,,Neutral,Neutral,,Neutral,0.23289979850243797,,0.22868576477055583,0.96017,,-0.09646293324863127,,0.43185353337568433,,Neutral,,Neutral,,0.2558190783760555,48.175,16.585,61.285,23.204,,False,48.175,,neutral,,,,False,61.285,,neutral,,,uncertain,,-0.1702,0.2264,-6.536,-1.90732514580004,0.0011477361281229,Benign,0.1472,benign,-3.304,available,https://doi.org/10.1101/2022.10.22.513328 +S116V,NP_000537:p.Ser116Val,,,,,saturation_mutlist,,,,,,,,0.19481,0.4693233048915863,,-0.22973105991783904,,-0.017460529958919516,,Neutral,Neutral,,Neutral,0.4460737959230657,,0.3431512532199093,1.37534,,-0.39358385835325876,,0.49087807082337065,,Neutral,,Neutral,,0.32543169285218276,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.3146,0.2264,-22.1457,-6.12861430951413,0.5244524006053052,Uncertain,0.6613,pathogenic,-3.904,available,https://doi.org/10.1101/2022.10.22.513328 +S116W,NP_000537:p.Ser116Trp,,,,,saturation_mutlist,,,,,,,,-0.09704,0.3572298574447632,,-0.6462086933124553,,-0.3716243466562277,,Neutral,Neutral,,Neutral,0.41053934461924896,,0.4536254623644443,0.66918,,-1.1383930778295792,,-0.2346065389147896,,Neutral,,Neutral,,0.34902903196037194,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.3469,0.2264,-22.1457,-6.22404420658784,0.8518344951736576,Pathogenic,0.7456,pathogenic,-4.377,available,https://doi.org/10.1101/2022.10.22.513328 +S116Y,NP_000537:p.Ser116Tyr,,,,,saturation_mutlist,,,,,,,,-0.07909,0.4262917685508728,,-0.2743296798463337,,-0.17670983992316686,,Neutral,Neutral,,Neutral,0.5116566227489894,,0.28670483396494834,0.61488,,-0.746357724536255,,-0.06573886226812753,,Neutral,,Neutral,,0.297889570210059,48.175,16.585,61.285,23.204,,False,48.175,,uncertain,,,,False,61.285,,uncertain,,,uncertain,,-0.342,0.2264,-22.1457,-6.22404420658784,0.8260139603137466,Pathogenic,0.6522,pathogenic,-4.125,available,https://doi.org/10.1101/2022.10.22.513328 +G117A,NP_000537:p.Gly117Ala,"hg19,17:g.7579337C>G, hg38,17:g.7676019C>G",,3.9826357083e-06,0.778,"cBioPortal,ClinVar,saturation_mutlist",1055289,Uncertain significance,1,,,,,0.82463,0.1765313959121704,0.30476,0.13585380934102517,0.564695,0.4802419046705126,Neutral,Neutral,Neutral,Neutral,Neutral,0.47873190699160395,0.7938083462650163,0.4234543189736804,1.98307,-0.13492,0.3980794590655394,0.9240750000000001,1.1905747295327698,Neutral,Neutral,Neutral,Neutral,0.8090071179332521,0.6917629854161061,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.2944,0.9651,-22.1457,-3.3959861353324,0.5908429624479663,Uncertain,0.539,ambiguous,-3.786,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G117C,NP_000537:p.Gly117Cys,,,,,saturation_mutlist,,,,,,,,1.01067,-0.002351675033569307,,0.6681308576891928,,0.8394004288445964,,Neutral,Neutral,,Neutral,0.3539391781567675,,0.27861055729946926,2.52077,,1.0175622623850782,,1.7691661311925393,,Uncertain,,Neutral,,0.6681529925160326,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.3541,0.9651,-22.1457,-3.12860849519928,0.8703854077951694,Pathogenic,0.8203,pathogenic,-4.176,available,https://doi.org/10.1101/2022.10.22.513328 +G117D,NP_000537:p.Gly117Asp,,,,,saturation_mutlist,,,,,,,,0.50994,0.14740334033966065,,-0.22540636044305765,,0.14226681977847117,,Neutral,Neutral,,Neutral,0.43147841126004766,,0.41339149335475106,1.55863,,-0.008133778809109149,,0.7752481105954454,,Neutral,,Neutral,,0.4770560973350307,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.3547,0.9651,-22.1457,-4.01603996263716,0.4375203996695488,Uncertain,0.9325,pathogenic,-3.777,available,https://doi.org/10.1101/2022.10.22.513328 +G117E,NP_000537:p.Gly117Glu,"hg19,17:g.7579337C>T, hg38,17:g.7676019C>T",,3.9826357083e-06,0.784,"COSMIC,ClinVar,saturation_mutlist",2450745,Uncertain significance,1,,,,,0.82202,0.23396783113479613,-0.66145,-0.0866587125129622,0.080285,0.3676806437435189,Neutral,Neutral,Neutral,Neutral,Neutral,0.5190551897293159,0.031574940485560206,0.4563060611452979,2.21904,-0.7407033333333333,0.18408723439118765,0.7391683333333334,1.201563617195594,Uncertain,Uncertain,Neutral,Neutral,0.9859414060457932,0.6358788050664204,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.354,0.9651,-22.1457,-3.5766581696358,0.4572631760483703,Uncertain,0.9517,pathogenic,-3.676,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G117F,NP_000537:p.Gly117Phe,,,,,saturation_mutlist,,,,,,,,1.00054,0.33926879286766054,,-0.2727505966521796,,0.3638947016739102,,Neutral,Neutral,,Neutral,0.45113714649587977,,0.3731833675431703,2.50518,,0.13951568614146517,,1.3223478430707327,,Uncertain,,Neutral,,0.7389612697369213,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.3922,0.9651,-22.1457,-4.97624722164543,0.7579089014217995,Pathogenic,0.9816,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328 +G117H,NP_000537:p.Gly117His,,,,,saturation_mutlist,,,,,,,,1.32159,0.2527238416671753,,-0.43768590608993224,,0.4419520469550339,,Neutral,Neutral,,Neutral,0.4623996732402552,,0.35872554719284366,3.19693,,-0.091948635304606,,1.552490682347697,,Uncertain,,Neutral,,0.5645188943076038,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.367,0.9651,-22.1457,-5.10008891973465,0.8212544187948694,Pathogenic,0.95,pathogenic,-4.011,available,https://doi.org/10.1101/2022.10.22.513328 +G117I,NP_000537:p.Gly117Ile,,,,,saturation_mutlist,,,,,,,,1.7028,0.43635291218757627,,0.40397270128121704,,1.0533863506406085,,Neutral,Neutral,,Neutral,0.5306048280927107,,0.6167222980755115,4.18617,,0.6108875129949501,,2.398528756497475,,Uncertain,,Uncertain,,1.0257497039849566,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.4379,0.9651,-22.1457,-4.24782712338559,0.7459687017699442,Pathogenic,0.9577,pathogenic,-4.162,available,https://doi.org/10.1101/2022.10.22.513328 +G117K,NP_000537:p.Gly117Lys,,,,,saturation_mutlist,,,,,,,,0.98843,0.3631547605991364,,-0.06243480963811906,,0.46299759518094047,,Neutral,Neutral,,Neutral,0.533160028426632,,0.4439013660236602,2.16619,,0.16051650230475173,,1.1633532511523759,,Uncertain,,Neutral,,0.6433832816497828,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.3869,0.9651,-22.1457,-3.09073133689788,0.2011288485694889,Benign,0.9665,pathogenic,-3.708,available,https://doi.org/10.1101/2022.10.22.513328 +G117L,NP_000537:p.Gly117Leu,,,,,saturation_mutlist,,,,,,,,1.04658,0.37837666034698486,,-0.40256926206226046,,0.3220053689688698,,Neutral,Neutral,,Neutral,0.505854496448639,,0.36575705895226074,2.39653,,-0.10695805739339324,,1.1447859713033033,,Uncertain,,Neutral,,0.6344322141649871,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.3383,0.9651,-8.8578,-4.79960574611016,0.8317499693496002,Pathogenic,0.9558,pathogenic,-4.009,available,https://doi.org/10.1101/2022.10.22.513328 +G117M,NP_000537:p.Gly117Met,,,,,saturation_mutlist,,,,,,,,1.05749,0.41528102636337283,,-0.1270479990391101,,0.46522100048044496,,Neutral,Neutral,,Neutral,0.45005171226101415,,0.3744275921612774,2.17934,,0.15985748793939483,,1.1695987439696973,,Uncertain,,Neutral,,0.6942093004670358,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.3443,0.9651,-22.1457,-5.10611538046356,0.8661741284384346,Pathogenic,0.9644,pathogenic,-4.224,available,https://doi.org/10.1101/2022.10.22.513328 +G117N,NP_000537:p.Gly117Asn,,,,,saturation_mutlist,,,,,,,,1.03215,0.19241210222244262,,-0.2703839389330115,,0.3808830305334942,,Neutral,Neutral,,Neutral,0.39141899506224376,,0.22038927811618358,2.18332,,-0.08148897226276096,,1.0509155138686197,,Uncertain,,Neutral,,0.43736061189038755,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.355,0.9651,-22.1457,-3.26156370406927,0.4156834673996206,Uncertain,0.8732,pathogenic,-3.732,available,https://doi.org/10.1101/2022.10.22.513328 +G117P,NP_000537:p.Gly117Pro,,,,,saturation_mutlist,,,,,,,,1.64751,0.43441895246505735,,2.117281265681081,,1.8823956328405405,,Uncertain,Neutral,,Neutral,0.6131671959732843,,1.9493851153836892,4.79585,,3.436612724787421,,4.116231362393711,,Destabilizing,,Destabilizing,,2.133098609967559,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.452,0.9651,-22.1457,-4.2175501024323,0.5705944880448508,Uncertain,0.9748,pathogenic,-3.683,available,https://doi.org/10.1101/2022.10.22.513328 +G117Q,NP_000537:p.Gly117Gln,,,,,saturation_mutlist,,,,,,,,1.07558,0.3416686487197876,,0.0215943224256774,,0.5485871612128387,,Neutral,Neutral,,Neutral,0.5281337028762109,,0.3618649105858229,2.26388,,0.3641020059802309,,1.3139910029901154,,Uncertain,,Neutral,,0.6165917856039456,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.3579,0.9651,-22.1457,-3.54294758527564,0.5485047926155499,Uncertain,0.9267,pathogenic,-3.762,available,https://doi.org/10.1101/2022.10.22.513328 +G117R,NP_000537:p.Gly117Arg,"hg19,17:g.7579338C>G, hg19,17:g.7579338C>T, hg38,17:g.7676020C>G, hg38,17:g.7676020C>T",,,0.770,"COSMIC,ClinVar,ClinVar,saturation_mutlist","1462102, 480758","Uncertain significance, Uncertain significance","2, 2",,,,,0.98855,0.4134783804416656,0.17199666666666666,-0.14129539342051356,0.5802733333333333,0.42362730328974324,Neutral,Neutral,Neutral,Neutral,Neutral,0.48864412257152445,0.40321326221023807,0.42716073434675345,2.3268,0.07585333333333337,-0.08410836404251121,1.2013266666666667,1.1213458179787443,Uncertain,Uncertain,Neutral,Neutral,0.8341007087210086,0.7054868111230999,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.3031,0.9651,-8.8578,-2.8438013983937,0.4603053800352202,Uncertain,0.9297,pathogenic,-3.894,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G117S,NP_000537:p.Gly117Ser,,,,,saturation_mutlist,,,,,,,,0.87777,0.15892261743545533,,0.1350868511353928,,0.5064284255676964,,Neutral,Neutral,,Neutral,0.47117846175452327,,0.5144585747459983,2.16184,,0.29912040674283374,,1.230480203371417,,Uncertain,,Neutral,,0.5199868263846289,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.1904,0.9651,-0.6053,-1.26278959382385,1.977112976983445e-05,Benign,0.2758,benign,-3.102,available,https://doi.org/10.1101/2022.10.22.513328 +G117T,NP_000537:p.Gly117Thr,,,,,saturation_mutlist,,,,,,,,1.49682,0.2715536403656006,,0.31577660994117407,,0.906298304970587,,Neutral,Neutral,,Neutral,0.5223155674742725,,0.5889398192085832,3.76881,,0.5650296663496999,,2.16691983317485,,Uncertain,,Uncertain,,0.8453237237913818,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.3772,0.9651,-22.1457,-2.60644894229147,0.7404866265029891,Pathogenic,0.663,pathogenic,-3.73,available,https://doi.org/10.1101/2022.10.22.513328 +G117V,NP_000537:p.Gly117Val,"hg19,17:g.7579337C>A, hg38,17:g.7676019C>A",,,0.832,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",837018,Uncertain significance,1,,,,,1.66892,0.42538913726806643,0.5497766666666667,0.45914563196483177,1.1093483333333334,1.064032815982416,Neutral,Neutral,Neutral,Neutral,Neutral,0.5401956574547081,1.0755537580655319,0.5773091865576035,4.17445,0.9393433333333335,0.6181936507736939,2.556896666666667,2.3963218253868472,Uncertain,Uncertain,Uncertain,Uncertain,2.5956059464709886,0.9448288718038212,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.3812,0.9651,-22.1457,-4.80793000393827,0.6298537946737008,Uncertain,0.8929,pathogenic,-3.926,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G117W,NP_000537:p.Gly117Trp,"hg19,17:g.7579338C>A",,,0.765,"cBioPortal,saturation_mutlist",,,,,,,,1.24632,0.3135468244552612,,-0.5619374842522636,,0.3421912578738682,,Neutral,Neutral,,Neutral,0.49297565263347465,,0.48068742787324326,3.10921,,-0.1899573560777271,,1.4596263219611365,,Uncertain,,Neutral,,0.7719961561425612,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.392,0.9651,-22.1457,-5.2937022889525,0.8636206587384927,Pathogenic,0.9691,pathogenic,-4.43,available,https://doi.org/10.1101/2022.10.22.513328 +G117Y,NP_000537:p.Gly117Tyr,,,,,saturation_mutlist,,,,,,,,1.02543,0.3382054889202118,,-0.2076960766508992,,0.40886696167455044,,Neutral,Neutral,,Neutral,0.48664058951860234,,0.3632057888261429,2.49954,,0.19321523833364354,,1.3463776191668217,,Uncertain,,Neutral,,0.7416318496248706,77.232,26.61,89.125,26.802,,False,77.232,,neutral,neutral,neutral,,False,89.125,,neutral,neutral,neutral,uncertain,,-0.3926,0.9651,-22.1457,-5.2937022889525,0.8708630270092321,Pathogenic,0.9759,pathogenic,-4.257,available,https://doi.org/10.1101/2022.10.22.513328 +T118A,NP_000537:p.Thr118Ala,"hg38,17:g.7676017T>C",,,0.842,"COSMIC,saturation_mutlist",,,,,,,,0.14783,0.015822027921676644,1.0913833333333331,0.40294965177290826,0.6196066666666665,0.2753898258864541,Neutral,Neutral,Neutral,Neutral,Neutral,0.15002147265111374,0.5796945212974004,0.14357195717207033,-0.41709,0.2573666666666667,0.2887926313286206,-0.07986166666666666,-0.06414868433568971,Neutral,Neutral,Neutral,Neutral,0.36556507002477995,0.12666225079971735,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,uncertain,,-0.2351,0.2115,-8.8578,-3.04870572018323,0.3266723516664855,Uncertain,0.3644,ambiguous,-3.481,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T118C,NP_000537:p.Thr118Cys,,,,,saturation_mutlist,,,,,,,,0.09595,-0.11046496987342833,,0.8180950836146418,,0.4570225418073209,,Neutral,Neutral,,Neutral,0.14793582524089172,,0.2511802063374802,-0.11414,,0.6686660337460585,,0.27726301687302923,,Neutral,,Neutral,,0.04218274057371024,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,uncertain,,-0.2709,0.2115,-8.8578,-4.11340270861261,0.3092550607421923,Benign,0.8132,pathogenic,-3.698,available,https://doi.org/10.1101/2022.10.22.513328 +T118D,NP_000537:p.Thr118Asp,,,,,saturation_mutlist,,,,,,,,-0.22931,-0.120059095621109,,0.16286049039913317,,-0.03322475480043342,,Neutral,Neutral,,Neutral,0.22561142488017005,,0.0550801645166699,-0.36094,,0.05139344162116144,,-0.15477327918941927,,Neutral,,Neutral,,0.21392442760824948,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,uncertain,,-0.4184,0.2115,-22.1457,-4.87423631104636,0.6555365309182115,Uncertain,0.9499,pathogenic,-3.931,available,https://doi.org/10.1101/2022.10.22.513328 +T118E,NP_000537:p.Thr118Glu,,,,,saturation_mutlist,,,,,,,,-0.24625,-0.003710284233093242,,0.15899749268572308,,-0.04362625365713846,,Neutral,Neutral,,Neutral,0.1893276609137278,,0.09282425327338292,-0.43489,,0.004272535609081474,,-0.21530873219545926,,Neutral,,Neutral,,0.15940552404989508,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,neutral,,-0.3938,0.2115,-22.1457,-4.13703358370453,0.4330246415171949,Uncertain,0.8606,pathogenic,-3.738,available,https://doi.org/10.1101/2022.10.22.513328 +T118F,NP_000537:p.Thr118Phe,,,,,saturation_mutlist,,,,,,,,-0.10199,0.15928519964218135,,-0.20369079769813117,,-0.15284039884906558,,Neutral,Neutral,,Neutral,0.2115745298121299,,0.2370561968222605,-0.08876,,-0.34011508402059687,,-0.21443754201029844,,Neutral,,Neutral,,0.09340667911999949,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,neutral,,-0.4101,0.2115,-22.1457,-6.58689514793135,0.6325050489892905,Uncertain,0.7931,pathogenic,-4.212,available,https://doi.org/10.1101/2022.10.22.513328 +T118G,NP_000537:p.Thr118Gly,,,,,saturation_mutlist,,,,,,,,0.54198,0.22635974168777465,,0.8531388085175262,,0.6975594042587632,,Neutral,Neutral,,Neutral,0.2312938951456858,,0.06868158282545565,-0.21208,,1.080177713582977,,0.4340488567914885,,Neutral,,Neutral,,0.3609613632092609,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,uncertain,,-0.3085,0.2115,-8.8578,-6.02911580137211,0.5660702432296895,Uncertain,0.779,pathogenic,-3.777,available,https://doi.org/10.1101/2022.10.22.513328 +T118H,NP_000537:p.Thr118His,,,,,saturation_mutlist,,,,,,,,0.3802,0.09291688799858092,,-0.17141889094212823,,0.10439055452893588,,Neutral,Neutral,,Neutral,0.12991778668063073,,0.08335529077761683,0.45756,,-0.26264054186370267,,0.09745972906814868,,Neutral,,Neutral,,0.05315328605531406,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,neutral,,-0.3904,0.2115,-22.1457,-6.58689514793135,0.6272129784997521,Uncertain,0.842,pathogenic,-3.947,available,https://doi.org/10.1101/2022.10.22.513328 +T118I,NP_000537:p.Thr118Ile,"hg19,17:g.7579334G>A, hg38,17:g.7676016G>A",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",419837,Likely benign,3,,,,,-0.20581,0.1657138979434967,0.5945600000000001,-0.09642464993162476,0.19437500000000005,-0.15111732496581237,Neutral,Neutral,Neutral,Neutral,Neutral,0.16491258470969,0.7503789899777312,0.2993478841800082,0.02413,0.4370766666666667,-0.4364320866566919,0.23060333333333335,-0.20615104332834597,Neutral,Neutral,Neutral,Neutral,0.45086819392022864,0.0954002775317272,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,neutral,,-0.2609,0.2115,-8.8578,-3.94190866086847,0.0830332885993737,Benign,0.7032,pathogenic,-3.632,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T118K,NP_000537:p.Thr118Lys,,,,,saturation_mutlist,,,,,,,,-0.1075,0.25600311636924744,,0.17064414001584036,,0.03157207000792018,,Neutral,Neutral,,Neutral,0.30752663505198913,,0.16620513680309953,0.03725,,0.23849875874899604,,0.137874379374498,,Neutral,,Neutral,,0.22625303605053715,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,neutral,,-0.386,0.2115,-22.1457,-4.95721027156549,0.4408627011101784,Uncertain,0.7421,pathogenic,-3.764,available,https://doi.org/10.1101/2022.10.22.513328 +T118L,NP_000537:p.Thr118Leu,,,,,saturation_mutlist,,,,,,,,-0.40562,0.11367682218551634,,-0.23044650037036088,,-0.3180332501851804,,Neutral,Neutral,,Neutral,0.15341239733298723,,0.16589480463110529,-0.558,,-0.6049448123561447,,-0.5814724061780724,,Neutral,,Neutral,,0.1473987576047697,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,neutral,,-0.3807,0.2115,-22.1457,-4.88215407172758,0.7203214651696899,Pathogenic,0.3972,ambiguous,-3.842,available,https://doi.org/10.1101/2022.10.22.513328 +T118M,NP_000537:p.Thr118Met,,,,,saturation_mutlist,,,,,,,,-0.3668,0.17477455854415894,,0.10171731001861511,,-0.13254134499069245,,Neutral,Neutral,,Neutral,0.15975922208012025,,0.14164205140590114,-0.74375,,-0.19465870598162494,,-0.4692043529908125,,Neutral,,Neutral,,0.09601469652708662,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,neutral,,-0.2717,0.2115,-7.273,-3.72087269096659,0.0587873814959232,Benign,0.2056,benign,-3.619,available,https://doi.org/10.1101/2022.10.22.513328 +T118N,NP_000537:p.Thr118Asn,,,,,saturation_mutlist,,,,,,,,0.10885,-0.019583121538162232,,0.10792920753651032,,0.10838960376825515,,Neutral,Neutral,,Neutral,0.16144058858861132,,0.1792118883250727,-0.03593,,0.00440215920785543,,-0.015763920396072283,,Neutral,,Neutral,,0.08208684140907438,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,uncertain,,-0.3585,0.2115,-22.1457,-3.90496608430963,0.4228189985131486,Uncertain,0.6829,pathogenic,-3.692,available,https://doi.org/10.1101/2022.10.22.513328 +T118P,NP_000537:p.Thr118Pro,,,,,saturation_mutlist,,,,,,,,0.88522,0.39413506388664243,,2.344193472687354,,1.614706736343677,,Uncertain,Neutral,,Neutral,0.3485135400083168,,1.042483871881276,-0.74151,,0.8216559694706462,,0.040072984735323114,,Neutral,,Neutral,,0.10756965841707425,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,uncertain,,-0.4672,0.2115,-22.1457,-5.02384101005698,0.5585502143103667,Uncertain,0.5204,ambiguous,-3.788,available,https://doi.org/10.1101/2022.10.22.513328 +T118Q,NP_000537:p.Thr118Gln,,,,,saturation_mutlist,,,,,,,,-0.05721,0.15851847887039183,,0.3592054946354297,,0.15099774731771487,,Neutral,Neutral,,Neutral,0.21104986712351367,,0.15325844107531042,-0.32761,,0.1883996114928754,,-0.0696051942535623,,Neutral,,Neutral,,0.12229150051590554,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,neutral,,-0.3679,0.2115,-22.1457,-4.75499563869662,0.6493564333611429,Uncertain,0.7177,pathogenic,-3.676,available,https://doi.org/10.1101/2022.10.22.513328 +T118R,NP_000537:p.Thr118Arg,"hg19,17:g.7579334G>C, hg38,17:g.7676016G>C",,,0.907,"COSMIC,ClinVar,saturation_mutlist",3460317,Uncertain significance,1,,,,,0.08285,0.27785789012908935,0.6736966666666667,-0.09337139274090393,0.37827333333333335,-0.00526069637045197,Neutral,Neutral,Neutral,Neutral,Neutral,0.26123362728378624,0.35655732641781773,0.19673926412123088,0.20555,1.25873,0.006299159124078169,0.73214,0.10592457956203909,Neutral,Neutral,Neutral,Neutral,0.3632351158684963,0.18948752735852925,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,neutral,,-0.3888,0.2115,-22.1457,-4.92809207480131,0.4568090995831356,Uncertain,0.6794,pathogenic,-3.834,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T118S,NP_000537:p.Thr118Ser,,,,,saturation_mutlist,,,,,,,,0.22005,-0.06753387093544004,,0.3842676273721555,,0.3021588136860777,,Neutral,Neutral,,Neutral,0.11791004099862039,,0.08970185643044185,-0.0245,,0.34479948866471427,,0.16014974433235712,,Neutral,,Neutral,,0.21674897481389246,83.888,29.309,38.605,18.356,,False,83.888,,neutral,,,,False,38.605,,neutral,,,uncertain,,-0.1988,0.2115,-8.8578,-2.77593355947402,0.3128861072223863,Benign,0.5334,ambiguous,-3.454,available,https://doi.org/10.1101/2022.10.22.513328 +T118V,NP_000537:p.Thr118Val,,,,,saturation_mutlist,,,,,,,,0.08165,0.1571324074268341,,-0.0176149466658391,,0.03201752666708045,,Neutral,Neutral,,Neutral,0.14404047134389897,,0.2611245292301583,0.16823,,-0.27554231736974705,,-0.05365615868487353,,Neutral,,Neutral,,0.21407666924284527,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,neutral,,-0.2485,0.2115,-8.8578,-3.95215341466343,0.0163588081705253,Benign,0.4668,ambiguous,-3.625,available,https://doi.org/10.1101/2022.10.22.513328 +T118W,NP_000537:p.Thr118Trp,,,,,saturation_mutlist,,,,,,,,0.25832,0.03697672843933105,,-0.43930112393936555,,-0.09049056196968278,,Neutral,Neutral,,Neutral,0.28118116902502666,,0.23879564466353403,0.47007,,-0.6274754539016545,,-0.07870272695082725,,Neutral,,Neutral,,0.02047370692299679,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,neutral,,-0.403,0.2115,-22.1457,-6.58689514793135,0.8630418219491252,Pathogenic,0.9448,pathogenic,-4.376,available,https://doi.org/10.1101/2022.10.22.513328 +T118Y,NP_000537:p.Thr118Tyr,,,,,saturation_mutlist,,,,,,,,-0.04908,0.16182611942291256,,-0.1617869827527768,,-0.10543349137638841,,Neutral,Neutral,,Neutral,0.19733031771041784,,0.2608874786665899,0.07882,,-0.20857564629154499,,-0.06487782314577249,,Neutral,,Neutral,,0.06209936830907636,83.888,29.309,38.605,18.356,,False,83.888,,uncertain,,,,False,38.605,,uncertain,,,neutral,,-0.3437,0.2115,-8.8578,-4.60516904540867,0.7611125690057705,Pathogenic,0.8869,pathogenic,-3.952,available,https://doi.org/10.1101/2022.10.22.513328 +A119C,NP_000537:p.Ala119Cys,,,,,saturation_mutlist,,,,,,,,0.17949,-0.09969342231750489,,0.6120699692586216,,0.3957799846293108,,Neutral,Neutral,,Neutral,0.19537702530307746,,0.19787121734027316,0.53155,,0.6717922350766915,,0.6016711175383458,,Neutral,,Neutral,,0.057523383595131934,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.3278,0.1344,-22.155,-4.27668812018761,0.8624141326905748,Pathogenic,0.9391,pathogenic,-4.265,available,https://doi.org/10.1101/2022.10.22.513328 +A119D,NP_000537:p.Ala119Asp,"hg19,17:g.7579331G>T, hg38,17:g.7676013G>T",,,0.944,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1732774,Uncertain significance,2,,,,,-0.11764,0.006697710752487176,0.5329933333333333,0.3969688957868526,0.20767666666666668,0.1396644478934263,Neutral,Neutral,Neutral,Neutral,Neutral,0.2550225796193971,0.45749424771125685,0.21623807107746973,-0.23911,-0.4120166666666667,-0.103992393160607,-0.3255633333333333,-0.1715511965803035,Neutral,Neutral,Neutral,Neutral,0.14700779624072854,0.14601031358658356,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.3417,0.1344,-8.8671,-6.3051272670469,0.8566529756205687,Pathogenic,0.9957,pathogenic,-4.059,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A119E,NP_000537:p.Ala119Glu,,,,,saturation_mutlist,,,,,,,,0.09262,0.014533243179321295,,0.15308971980212435,,0.12285485990106218,,Neutral,Neutral,,Neutral,0.2945020707009448,,0.1978144158465527,-0.1673,,-0.24424429723939453,,-0.20577214861969728,,Neutral,,Neutral,,0.16460247746676507,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.3952,0.1344,-22.155,-6.3051272670469,0.8371809438782941,Pathogenic,0.9839,pathogenic,-4.072,available,https://doi.org/10.1101/2022.10.22.513328 +A119F,NP_000537:p.Ala119Phe,,,,,saturation_mutlist,,,,,,,,0.23476,0.2973591959476471,,-0.6908049991855209,,-0.22802249959276044,,Neutral,Neutral,,Neutral,0.29511965617080577,,0.13851998719097353,0.25858,,-0.3676781778385627,,-0.05454908891928137,,Neutral,,Neutral,,0.08341558523530745,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.3779,0.1344,-22.155,-6.38204038631388,0.8412958420806412,Pathogenic,0.9736,pathogenic,-4.292,available,https://doi.org/10.1101/2022.10.22.513328 +A119G,NP_000537:p.Ala119Gly,"hg19,17:g.7579330_7579331delinsAC, hg19,17:g.7579331G>C, hg38,17:g.7676012_7676013delinsAC, hg38,17:g.7676013G>C",,,0.856,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",949408,Conflicting classifications of pathogenicity,1,,,,,0.37623,0.2753939068317413,1.38492,1.0561525375469463,0.880575,0.7161912687734732,Neutral,Neutral,Neutral,Neutral,Neutral,0.14775797100236573,0.40561211298480726,0.32923537476120035,0.12281,0.6346933333333333,0.5660967076257888,0.37875166666666665,0.3444533538128944,Neutral,Neutral,Neutral,Neutral,0.16326684544702338,0.05826672553927906,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,uncertain,,-0.3213,0.1344,-22.155,-5.75946166142197,0.5611907604189201,Uncertain,0.8488,pathogenic,-3.687,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A119H,NP_000537:p.Ala119His,,,,,saturation_mutlist,,,,,,,,0.55468,0.13783097982406617,,-0.32930823360428535,,0.1126858831978573,,Neutral,Neutral,,Neutral,0.2407616322801825,,0.10373177045462055,0.55493,,-0.39182523864562313,,0.08155238067718845,,Neutral,,Neutral,,0.13983883283800538,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.382,0.1344,-22.155,-6.14196185588319,0.8521184244496525,Pathogenic,0.972,pathogenic,-4.14,available,https://doi.org/10.1101/2022.10.22.513328 +A119I,NP_000537:p.Ala119Ile,,,,,saturation_mutlist,,,,,,,,0.43065,0.24552071928977967,,-0.4156644683686221,,0.007492765815688945,,Neutral,Neutral,,Neutral,0.3124759746551196,,0.13471907982010775,0.50787,,-0.32237698685650423,,0.0927465065717479,,Neutral,,Neutral,,0.18055540759625544,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.3674,0.1344,-22.155,-5.93814277022035,0.8708042073713154,Pathogenic,0.9856,pathogenic,-4.238,available,https://doi.org/10.1101/2022.10.22.513328 +A119K,NP_000537:p.Ala119Lys,,,,,saturation_mutlist,,,,,,,,0.04527,0.312909197807312,,0.2106736876429368,,0.1279718438214684,,Neutral,Neutral,,Neutral,0.27013844113557683,,0.17618412431575683,0.0799,,-0.25001591347179847,,-0.08505795673589923,,Neutral,,Neutral,,0.11403198429354605,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.3998,0.1344,-22.155,-5.4665769148994,0.3842096195255201,Uncertain,0.9794,pathogenic,-3.879,available,https://doi.org/10.1101/2022.10.22.513328 +A119L,NP_000537:p.Ala119Leu,,,,,saturation_mutlist,,,,,,,,-0.35101,0.1445788025856018,,-0.8835460983077134,,-0.6172780491538566,,Neutral,Neutral,,Neutral,0.29607336611282403,,0.17759430913250465,0.16906,,-0.5987372875384808,,-0.2148386437692404,,Neutral,,Neutral,,0.09279443165789263,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.3722,0.1344,-22.155,-5.50880566265892,0.8473608779283173,Pathogenic,0.8575,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328 +A119M,NP_000537:p.Ala119Met,,,,,saturation_mutlist,,,,,,,,-0.49046,0.18116285800933837,,-0.4680583996380346,,-0.4792591998190173,,Neutral,Neutral,,Neutral,0.22689574365523218,,0.15238958798800967,0.31756,,-0.25604755391069006,,0.030756223044654973,,Neutral,,Neutral,,0.06420969104298724,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.3309,0.1344,-22.155,-4.54758151803318,0.858572564882069,Pathogenic,0.9288,pathogenic,-4.276,available,https://doi.org/10.1101/2022.10.22.513328 +A119N,NP_000537:p.Ala119Asn,,,,,saturation_mutlist,,,,,,,,0.124,0.12483887910842896,,0.153527727662889,,0.1387638638314445,,Neutral,Neutral,,Neutral,0.23457466375585384,,0.12727220903998793,0.28319,,-0.11800804735497529,,0.08259097632251236,,Neutral,,Neutral,,0.08806394684938125,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.3799,0.1344,-22.155,-5.56175638138794,0.7321627762930376,Pathogenic,0.9586,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328 +A119P,NP_000537:p.Ala119Pro,"hg19,17:g.7579332C>G, hg38,17:g.7676014C>G",,,0.899,"ClinVar,saturation_mutlist",481073,Uncertain significance,2,,,,,0.57614,0.6319826531410218,2.390363333333333,1.2607986588469136,1.4832516666666666,0.9184693294234567,Uncertain,Neutral,Neutral,Neutral,Neutral,0.26245554766453455,1.6506342510750898,0.6907467380937315,2.47948,2.4997700000000003,3.381123770302999,2.489625,2.9303018851514997,Uncertain,Uncertain,Uncertain,Uncertain,0.7404985431901041,1.5290119646621294,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.4492,0.1344,-22.155,-4.29837734991741,0.5695207436938106,Uncertain,0.9356,pathogenic,-3.698,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A119Q,NP_000537:p.Ala119Gln,,,,,saturation_mutlist,,,,,,,,0.13955,0.11863333225250244,,0.0585699471805351,,0.09905997359026755,,Neutral,Neutral,,Neutral,0.2089836854640564,,0.08486988216450447,0.09872,,0.014697700755716603,,0.056708850377858305,,Neutral,,Neutral,,0.06849266585393722,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.3774,0.1344,-22.155,-6.12452429897059,0.6975397973374314,Pathogenic,0.9055,pathogenic,-3.914,available,https://doi.org/10.1101/2022.10.22.513328 +A119R,NP_000537:p.Ala119Arg,,,,,saturation_mutlist,,,,,,,,0.20326,0.35572110772132876,,-0.2063310729682347,,-0.0015355364841173474,,Neutral,Neutral,,Neutral,0.2612702591905261,,0.04815490753312555,0.08222,,-0.4123162607943947,,-0.16504813039719735,,Neutral,,Neutral,,0.13453234582292023,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.4105,0.1344,-22.155,-6.08010840545269,0.8256439209195587,Pathogenic,0.91,pathogenic,-4.077,available,https://doi.org/10.1101/2022.10.22.513328 +A119S,NP_000537:p.Ala119Ser,,,,,saturation_mutlist,,,,,,,,0.19961,0.04759920597076415,,0.36627978477875517,,0.2829448923893776,,Neutral,Neutral,,Neutral,0.16169644318937412,,0.13704957271930948,0.3869,,0.0821249992766841,,0.23451249963834206,,Neutral,,Neutral,,0.14363940924177984,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,uncertain,,-0.2925,0.1344,-22.155,-3.24051340143622,0.1202174396939922,Benign,0.4178,ambiguous,-3.516,available,https://doi.org/10.1101/2022.10.22.513328 +A119T,NP_000537:p.Ala119Thr,,,,,saturation_mutlist,,,,,,,,0.64568,0.08393577098846436,1.02823,0.11802236138098181,0.836955,0.3818511806904909,Neutral,Neutral,Neutral,Neutral,Neutral,0.2589564461185949,0.5068518069416346,0.06481408090075269,0.77272,0.16337666666666664,-0.04230365207279446,0.4680483333333333,0.3652081739636027,Neutral,Neutral,Neutral,Neutral,0.23338741601799262,0.11953439907975873,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.2163,0.1344,-6.0599,-1.94280040245004,0.006936515177311,Benign,0.6385,pathogenic,-3.308,available,https://doi.org/10.1101/2022.10.22.513328 +A119V,NP_000537:p.Ala119Val,"hg38,17:g.7676013G>A",,,0.906,"COSMIC,saturation_mutlist",,,,,,,,0.41682,0.14746851444244385,0.7613366666666668,-0.31373179225313647,0.5890783333333334,0.05154410387343178,Neutral,Neutral,Neutral,Neutral,Neutral,0.28469029094175735,0.4563577592440193,0.22806672237796735,0.73988,0.8529466666666666,-0.26025621057775505,0.7964133333333333,0.23981189471112246,Neutral,Neutral,Neutral,Neutral,0.9884284060849099,0.16493962468969128,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.2955,0.1344,-22.155,-5.19463022480001,0.7875647560767945,Pathogenic,0.9157,pathogenic,-3.832,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A119W,NP_000537:p.Ala119Trp,,,,,saturation_mutlist,,,,,,,,0.64097,0.23629071354866027,,-1.035491070706371,,-0.19726053535318544,,Neutral,Neutral,,Neutral,0.25961194337863297,,0.10368974105934298,0.43472,,-0.6873124170269008,,-0.12629620851345041,,Neutral,,Neutral,,0.10309155963820488,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.3888,0.1344,-22.155,-6.38204038631388,0.8703198761976335,Pathogenic,0.9949,pathogenic,-4.49,available,https://doi.org/10.1101/2022.10.22.513328 +A119Y,NP_000537:p.Ala119Tyr,,,,,saturation_mutlist,,,,,,,,0.25241,0.29397857308387754,,-0.5089218214157217,,-0.12825591070786085,,Neutral,Neutral,,Neutral,0.2994291735329614,,0.028409597376745747,0.29072,,-0.29267086375870016,,-0.0009754318793500916,,Neutral,,Neutral,,0.11288995845916201,42.583,20.978,76.5,11.593,,False,42.583,,neutral,neutral,neutral,,False,76.5,,neutral,neutral,neutral,neutral,,-0.3971,0.1344,-22.155,-5.83273671044891,0.857859601798747,Pathogenic,0.9863,pathogenic,-4.202,available,https://doi.org/10.1101/2022.10.22.513328 +K120A,NP_000537:p.Lys120Ala,,,,,saturation_mutlist,,,,,,,,0.20645,-0.1607241332530975,,0.1531360453132187,,0.17979302265660935,,Neutral,Neutral,,Neutral,0.09366376592076872,,0.03327111112697686,0.13527,,-0.05190927836476936,,0.04168036081761532,,Neutral,,Neutral,,0.1729395455053801,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.318,0.0442,-22.155,-5.42345654134594,0.7836222577138889,Pathogenic,0.9942,pathogenic,-4.103,available,https://doi.org/10.1101/2022.10.22.513328 +K120C,NP_000537:p.Lys120Cys,,,,,saturation_mutlist,,,,,,,,0.35383,-0.36742525577545165,,0.8195065837347663,,0.5866682918673831,,Neutral,Neutral,,Neutral,0.09875532263272459,,0.036147902983370624,0.30206,,0.6888978867858363,,0.49547894339291815,,Neutral,,Neutral,,0.05783965567600051,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.3882,0.0442,-22.155,-6.04496054322028,0.8657877618328808,Pathogenic,0.9994,pathogenic,-4.483,available,https://doi.org/10.1101/2022.10.22.513328 +K120D,NP_000537:p.Lys120Asp,,,,,saturation_mutlist,,,,,,,,-0.042,-0.3493307197093964,,-0.13998829304953977,,-0.09099414652476989,,Neutral,Neutral,,Neutral,0.1802534291435723,,0.12955204733110035,-0.09931,,-0.3949819431688219,,-0.24714597158441096,,Neutral,,Neutral,,0.19502156412249014,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.427,0.0442,-22.155,-5.60095398876375,0.8614923113132844,Pathogenic,0.9983,pathogenic,-4.444,available,https://doi.org/10.1101/2022.10.22.513328 +K120E,NP_000537:p.Lys120Glu,"hg19,17:g.7579329T>C, hg19,17:g.7676011T>C, hg38,17:g.7676011T>C",,,0.925,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141098,Conflicting classifications of pathogenicity,1,,,,,-0.22422,-0.3159735834598541,-0.005556666666666664,-0.2152555625139622,-0.11488833333333333,-0.2197377812569811,Neutral,Neutral,Neutral,Neutral,Neutral,0.1415064681796089,0.09796886081244839,0.05648809185248979,-0.29453,-0.37255999999999995,-0.38542251322704013,-0.333545,-0.33997625661352004,Neutral,Neutral,Neutral,Neutral,0.5575898019751317,0.25059783867668994,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,neutral,-0.3429,0.0442,-22.155,-4.63546258999546,0.8675905169079631,Pathogenic,0.9978,pathogenic,-4.396,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K120F,NP_000537:p.Lys120Phe,,,,,saturation_mutlist,,,,,,,,0.06763,-0.06175428628921508,,-0.0195204564122342,,0.0240547717938829,,Neutral,Neutral,,Neutral,0.10151400804310849,,0.02696414144234975,-0.06004,,-0.18496460294613085,,-0.12250230147306543,,Neutral,,Neutral,,0.1854017121628402,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,neutral,,-0.3891,0.0442,-22.155,-6.40246030540746,0.8539927060900383,Pathogenic,0.9997,pathogenic,-4.524,available,https://doi.org/10.1101/2022.10.22.513328 +K120G,NP_000537:p.Lys120Gly,,,,,saturation_mutlist,,,,,,,,0.2956,0.10573604345321654,,0.6046274354741785,,0.45011371773708925,,Neutral,Neutral,,Neutral,0.13262019511689108,,0.10032890111414229,-0.7204,,0.28236577481686304,,-0.2190171125915685,,Neutral,,Neutral,,0.013683039746629655,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.3772,0.0442,-22.155,-7.28062631544254,0.8698622570857691,Pathogenic,0.9951,pathogenic,-4.346,available,https://doi.org/10.1101/2022.10.22.513328 +K120H,NP_000537:p.Lys120His,,,,,saturation_mutlist,,,,,,,,0.36427,-0.19146459817886352,,-0.19831358574940483,,0.08297820712529758,,Neutral,Neutral,,Neutral,0.08947737595964628,,0.04546613305618472,0.31244,,-0.4485085780417306,,-0.06803428902086531,,Neutral,,Neutral,,0.20191186375771386,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.3281,0.0442,-22.155,-6.40246030540746,0.868361784799802,Pathogenic,0.9946,pathogenic,-4.224,available,https://doi.org/10.1101/2022.10.22.513328 +K120I,NP_000537:p.Lys120Ile,,,,,saturation_mutlist,,,,,,,,0.17968,-0.14050466895103453,,-0.06575436200118763,,0.05696281899940619,,Neutral,Neutral,,Neutral,0.11446714861411263,,0.13468614613354785,0.56608,,-0.13444384112839805,,0.215818079435801,,Neutral,,Neutral,,0.1834570545973485,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.3563,0.0442,-22.155,-7.28062631544254,0.8704956913637367,Pathogenic,0.9992,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328 +K120L,NP_000537:p.Lys120Leu,,,,,saturation_mutlist,,,,,,,,0.08779,-0.13680036425590514,,-0.29591745981363354,,-0.10406372990681677,,Neutral,Neutral,,Neutral,0.06215193598090192,,0.08649886368958508,0.0288,,-0.5486761550120837,,-0.2599380775060418,,Neutral,,Neutral,,0.14234979905037315,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.355,0.0442,-22.155,-7.28062631544254,0.8706004015923767,Pathogenic,0.9973,pathogenic,-4.483,available,https://doi.org/10.1101/2022.10.22.513328 +K120M,NP_000537:p.Lys120Met,"hg19,17:g.7579328T>A, hg38,17:g.7676010T>A",,,0.920,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",917693,Uncertain significance,2,,,,,0.18806,-0.023191598653793326,-0.11020333333333333,0.004520072355937432,0.038928333333333336,0.09629003617796872,Neutral,Neutral,Neutral,Neutral,Neutral,0.05670197297801308,0.20373760941193184,0.05246108131169472,-0.07504,-0.10963666666666666,-0.23679455515940173,-0.09233833333333333,-0.15591727757970086,Neutral,Neutral,Neutral,Neutral,0.3750258793144222,0.15581601022063168,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.2603,0.0442,-8.8671,-7.28062631544254,0.8707780335020721,Pathogenic,0.997,pathogenic,-4.416,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K120N,NP_000537:p.Lys120Asn,"hg19,17:g.7579327C>A, hg19,17:g.7579327C>G, hg19,17:g.7676009C>A, hg38,17:g.7676009C>A",,,0.862,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.25399,-0.17198412775993344,-0.15226666666666666,0.016327496387745038,0.050861666666666666,0.13515874819387252,Neutral,Neutral,Neutral,Neutral,Neutral,0.09965506875416492,0.1375574702523357,0.05797187496484959,0.24704,-0.14648666666666668,-0.15745669360539427,0.050276666666666664,0.04479165319730287,Neutral,Neutral,Neutral,Neutral,0.14122181709007367,0.10976167987571527,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.3362,0.0442,-22.155,-5.54074595282046,0.7438368825816526,Pathogenic,0.9987,pathogenic,-4.059,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K120P,NP_000537:p.Lys120Pro,,,,,saturation_mutlist,,,,,,,,0.16387,0.028875865936279305,,0.8204076068550147,,0.4921388034275073,,Neutral,Neutral,,Neutral,0.26781432709539765,,0.581171295873517,1.03807,,0.3782336199928588,,0.7081518099964295,,Neutral,,Neutral,,0.5259211500713957,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.4923,0.0442,-22.155,-7.28062631544254,0.8703396077688951,Pathogenic,0.9866,pathogenic,-4.361,available,https://doi.org/10.1101/2022.10.22.513328 +K120Q,NP_000537:p.Lys120Gln,"hg19,17:g.7579329T>G, hg19,17:g.7676011T>G, hg38,17:g.7676011T>G",,,0.899,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",423255,Uncertain significance,2,,,,,-0.03033,-0.1300746929645538,-0.3,0.13838468773355483,-0.165165,0.05402734386677742,Neutral,Neutral,Neutral,Neutral,Neutral,0.061531244448009385,0.2686950758759825,0.027266385108014733,-0.00623,-0.34716333333333327,-0.041495416566590566,-0.17669666666666664,-0.023862708283295283,Neutral,Neutral,Neutral,Neutral,0.4362749787563904,0.16097445089008294,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.3172,0.0442,-22.155,-4.56771286265142,0.7966803097578257,Pathogenic,0.9942,pathogenic,-3.993,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K120R,NP_000537:p.Lys120Arg,"hg19,17:g.7579328T>C, hg38,17:g.7676009_7676010delinsTC, hg38,17:g.7676010T>C",,,0.861,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1360099,Uncertain significance,2,,,,,0.05923,0.02559542894363401,0.31655,-0.0815389040907521,0.18789,-0.011154452045376049,Neutral,Neutral,Neutral,Neutral,Neutral,0.0330817052045559,0.07092571089997385,0.028275106855791467,0.02132,0.17483,-0.23383377136017158,0.09807500000000001,-0.10625688568008579,Neutral,Neutral,Neutral,Neutral,0.252029031661037,0.10990032701668506,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.2516,0.0442,-22.155,-3.63933736432837,0.6458355451233061,Uncertain,0.6345,pathogenic,-3.649,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K120S,NP_000537:p.Lys120Ser,,,,,saturation_mutlist,,,,,,,,0.28966,-0.22991222739219666,,0.06315874858670427,,0.17640937429335213,,Neutral,Neutral,,Neutral,0.09271198065255686,,0.11792910228697402,0.09333,,-0.1828394238160704,,-0.044754711908035205,,Neutral,,Neutral,,0.16464030808680563,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.3282,0.0442,-22.155,-4.38727971150328,0.6559657944313169,Uncertain,0.9962,pathogenic,-4.037,available,https://doi.org/10.1101/2022.10.22.513328 +K120T,NP_000537:p.Lys120Thr,"hg19,17:g.7579328T>G, hg38,17:g.7676010T>G",,,0.917,"COSMIC,ClinVar,saturation_mutlist",3780731,Uncertain significance,1,,,,,0.17886,-0.18776488900184632,0.06020333333333333,0.10237542437521356,0.11953166666666666,0.14061771218760677,Neutral,Neutral,Neutral,Neutral,Neutral,0.09094968672115555,0.07792837580468077,0.09158625567495654,0.37135,-0.3615633333333334,-0.06143453248943146,0.004893333333333305,0.15495773375528427,Neutral,Neutral,Neutral,Neutral,0.4792267549802378,0.13675721647867403,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.34,0.0442,-22.155,-5.90090569288512,0.8212977215190145,Pathogenic,0.9939,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K120V,NP_000537:p.Lys120Val,,,,,saturation_mutlist,,,,,,,,0.2553,-0.1745137333869934,,0.050427657850427555,,0.1528638289252138,,Neutral,Neutral,,Neutral,0.1455815022249866,,0.077643243154884,0.80552,,-0.009170250162601232,,0.3981748749186994,,Neutral,,Neutral,,0.16574502302344846,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,uncertain,,-0.2724,0.0442,-8.8671,-7.28062631544254,0.8615982983534328,Pathogenic,0.9979,pathogenic,-4.483,available,https://doi.org/10.1101/2022.10.22.513328 +K120W,NP_000537:p.Lys120Trp,,,,,saturation_mutlist,,,,,,,,0.17953,-0.12860245347023008,,-0.41646954726216284,,-0.11846977363108142,,Neutral,Neutral,,Neutral,0.11583745608717204,,0.09345640985133845,-0.00347,,-0.5418569389434119,,-0.27266346947170594,,Neutral,,Neutral,,0.2901215613011152,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,neutral,,-0.3981,0.0442,-22.155,-6.40246030540746,0.8707554770938442,Pathogenic,0.9993,pathogenic,-4.654,available,https://doi.org/10.1101/2022.10.22.513328 +K120Y,NP_000537:p.Lys120Tyr,,,,,saturation_mutlist,,,,,,,,0.02419,-0.06845565915107726,,0.021293499677557465,,0.022741749838778733,,Neutral,Neutral,,Neutral,0.12711449921725937,,0.05765699090516615,0.06108,,-0.08969695711209776,,-0.014308478556048877,,Neutral,,Neutral,,0.19215192745024906,88.323,10.555,84.915,12.308,,False,88.323,,neutral,neutral,neutral,,False,84.915,,neutral,neutral,neutral,neutral,,-0.374,0.0442,-22.155,-6.03995345266635,0.8506298220477309,Pathogenic,0.9987,pathogenic,-4.417,available,https://doi.org/10.1101/2022.10.22.513328 +S121A,NP_000537:p.Ser121Ala,,,,,saturation_mutlist,,,,,,,,0.41002,0.08892418861389156,,0.3296052855783664,,0.3698126427891832,,Neutral,Neutral,,Neutral,0.06024129731710715,,0.08205651861476013,-0.01499,,0.2324086774958687,,0.10870933874793434,,Neutral,,Neutral,,0.10033566550294257,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,uncertain,,-0.278,0.0222,-22.155,-2.88339815913178,0.5701486809014564,Uncertain,0.7746,pathogenic,-3.605,available,https://doi.org/10.1101/2022.10.22.513328 +S121C,NP_000537:p.Ser121Cys,,,,,saturation_mutlist,,,,,,,,0.30064,-0.21668899297714234,,0.6064608370654625,,0.45355041853273126,,Neutral,Neutral,,Neutral,0.09688818252104195,,0.1811834049130897,-0.08841,,0.7223955155650752,,0.3169927577825376,,Neutral,,Neutral,,0.06281512548165798,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3285,0.0222,-22.155,-3.61256238654893,0.765557032265726,Pathogenic,0.9438,pathogenic,-4.078,available,https://doi.org/10.1101/2022.10.22.513328 +S121D,NP_000537:p.Ser121Asp,,,,,saturation_mutlist,,,,,,,,-0.05211,-0.1269692516326904,,-0.4378503476212276,,-0.2449801738106138,,Neutral,Neutral,,Neutral,0.13073722118949532,,0.11458727253804628,-0.40391,,-0.23429152970902878,,-0.3191007648545144,,Neutral,,Neutral,,0.1012613447095703,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3767,0.0222,-22.155,-5.79217437486609,0.8633620873491314,Pathogenic,0.9965,pathogenic,-4.19,available,https://doi.org/10.1101/2022.10.22.513328 +S121E,NP_000537:p.Ser121Glu,,,,,saturation_mutlist,,,,,,,,0.0641,-0.046651549339294406,,-0.14104371113563366,,-0.03847185556781683,,Neutral,Neutral,,Neutral,0.08843449595041103,,0.18416409061410083,-0.45545,,-0.11763273989162475,,-0.28654136994581236,,Neutral,,Neutral,,0.1436434348461434,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3499,0.0222,-22.155,-5.79217437486609,0.8703269038904776,Pathogenic,0.9959,pathogenic,-4.25,available,https://doi.org/10.1101/2022.10.22.513328 +S121F,NP_000537:p.Ser121Phe,"hg19,17:g.7579325G>A, hg38,17:g.7676007G>A",,,0.928,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.16748,0.12943449020385742,0.14251666666666665,-0.06271362939119027,-0.012481666666666669,-0.11509681469559513,Neutral,Neutral,Neutral,Neutral,Neutral,0.10204786186793734,0.13687580753693798,0.12862036311749872,-0.5252,-0.4445566666666667,-0.23083847606862284,-0.48487833333333336,-0.3780192380343114,Neutral,Neutral,Neutral,Neutral,0.3093793175950124,0.044365715576189735,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3561,0.0222,-22.155,-3.87121486998236,0.8643497312344928,Pathogenic,0.9907,pathogenic,-4.37,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S121G,NP_000537:p.Ser121Gly,,,,,saturation_mutlist,,,,,,,,-0.30447,-0.0787902057170868,,0.02434868075585069,,-0.14006065962207467,,Neutral,Neutral,,Neutral,0.44879817556707746,,0.19740241187706226,0.09487,,0.5135419431056377,,0.30420597155281887,,Neutral,,Neutral,,0.3611683816552567,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,uncertain,,-0.2194,0.0222,-8.8671,-5.57161837826126,0.640821789555123,Uncertain,0.907,pathogenic,-3.722,available,https://doi.org/10.1101/2022.10.22.513328 +S121H,NP_000537:p.Ser121His,,,,,saturation_mutlist,,,,,,,,0.23555,0.01740612030029297,,-0.34667920100135013,,-0.05556460050067506,,Neutral,Neutral,,Neutral,0.08283417092941975,,0.1490779303134456,-0.07937,,-0.3153276764546619,,-0.19734883822733096,,Neutral,,Neutral,,0.12465369480298838,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3573,0.0222,-22.155,-4.7861890334447,0.8331799204256038,Pathogenic,0.9875,pathogenic,-4.156,available,https://doi.org/10.1101/2022.10.22.513328 +S121I,NP_000537:p.Ser121Ile,,,,,saturation_mutlist,,,,,,,,1.98587,0.41481453537940977,,1.1448215272550746,,1.5653457636275374,,Neutral,Neutral,,Neutral,0.33106603574732435,,0.35427968970333384,-0.19508,,0.20398670107969272,,0.004453350539846357,,Neutral,,Neutral,,0.47596398517223903,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3592,0.0222,-22.155,-7.22257451018822,0.7974786034438025,Pathogenic,0.9901,pathogenic,-4.375,available,https://doi.org/10.1101/2022.10.22.513328 +S121K,NP_000537:p.Ser121Lys,,,,,saturation_mutlist,,,,,,,,0.03907,0.15303233504295347,,-0.15132376815368123,,-0.05612688407684062,,Neutral,Neutral,,Neutral,0.07399302769378525,,0.22432458018246831,-0.32238,,-0.0455174080787176,,-0.1839487040393588,,Neutral,,Neutral,,0.18467534205979347,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3666,0.0222,-22.155,-5.17881081672149,0.8107863267030521,Pathogenic,0.9986,pathogenic,-3.956,available,https://doi.org/10.1101/2022.10.22.513328 +S121L,NP_000537:p.Ser121Leu,,,,,saturation_mutlist,,,,,,,,0.19138,0.1860194337368011,,-0.15817838119399327,,0.01660080940300336,,Neutral,Neutral,,Neutral,0.11989228723536095,,0.056285191313830404,-0.43155,,-0.3971296656016823,,-0.41433983280084113,,Neutral,,Neutral,,0.08410458292061865,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3555,0.0222,-22.155,-7.22257451018822,0.8654774530507405,Pathogenic,0.9858,pathogenic,-4.336,available,https://doi.org/10.1101/2022.10.22.513328 +S121M,NP_000537:p.Ser121Met,,,,,saturation_mutlist,,,,,,,,0.1242,0.13486889004707334,,0.0625148800746472,,0.0933574400373236,,Neutral,Neutral,,Neutral,0.08190970920976592,,0.05893849892107646,-0.40815,,-0.044974194379342226,,-0.22656209718967113,,Neutral,,Neutral,,0.06015570086877087,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3265,0.0222,-22.155,-7.22257451018822,0.8582265101531388,Pathogenic,0.9709,pathogenic,-4.35,available,https://doi.org/10.1101/2022.10.22.513328 +S121N,NP_000537:p.Ser121Asn,,,,,saturation_mutlist,,,,,,,,0.0361,-0.18440211772918702,,-0.5192422805316322,,-0.2415711402658161,,Neutral,Neutral,,Neutral,0.20825965115145753,,0.1693349926119311,-0.17189,,-0.21298850536253836,,-0.19243925268126916,,Neutral,,Neutral,,0.22350967460192117,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3003,0.0222,-22.155,-4.48590039048582,0.6730832011556374,Uncertain,0.9749,pathogenic,-3.705,available,https://doi.org/10.1101/2022.10.22.513328 +S121P,NP_000537:p.Ser121Pro,"hg19,17:g.7579326A>G, hg38,17:g.7676008A>G",,,0.944,"ClinVar,saturation_mutlist",854451,Uncertain significance,2,,,,,3.18061,0.6576283693313598,3.3524933333333333,4.564459619355612,3.2665516666666665,3.8725348096778065,Destabilizing,Destabilizing,Neutral,Destabilizing,Destabilizing,0.289130782757026,1.0208619897039084,0.7415776033756263,0.28869,2.4954666666666667,2.383427727118832,1.3920783333333333,1.336058863559416,Uncertain,Uncertain,Neutral,Neutral,3.3204961576279866,0.909407799728201,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.4315,0.0222,-22.155,-7.22257451018822,0.8646101591036084,Pathogenic,0.9975,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S121Q,NP_000537:p.Ser121Gln,,,,,saturation_mutlist,,,,,,,,0.10538,0.10327510356903075,,0.1669527645162199,,0.13616638225810995,,Neutral,Neutral,,Neutral,0.08171391951860049,,0.14117646792209484,-0.24568,,0.1676134426569749,,-0.03903327867151256,,Neutral,,Neutral,,0.09859619992919261,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3199,0.0222,-22.155,-4.42658788278325,0.7369001124810637,Pathogenic,0.9903,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328 +S121R,NP_000537:p.Ser121Arg,,,,,saturation_mutlist,,,,,,,,0.08494,0.18839631199836726,,-0.247182067250987,,-0.0811210336254935,,Neutral,Neutral,,Neutral,0.06507508264437052,,0.211975646543177,-0.08362,,-0.0910549827430394,,-0.0873374913715197,,Neutral,,Neutral,,0.13558908744549,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3719,0.0222,-22.155,-4.90349223605351,0.6071277607450033,Uncertain,0.9978,pathogenic,-3.955,available,https://doi.org/10.1101/2022.10.22.513328 +S121T,NP_000537:p.Ser121Thr,,,,,saturation_mutlist,,,,,,,,1.26872,0.2535112130641937,1.1571433333333332,0.7934162638097289,1.2129316666666665,1.0310681319048645,Neutral,Neutral,Neutral,Neutral,Neutral,0.2226217691654559,0.11178691525497172,0.06496895712630114,-0.04586,0.1507933333333333,0.32174575363010954,0.052466666666666655,0.13794287681505477,Neutral,Neutral,Neutral,Neutral,0.7074944008416054,0.23348305293023536,82.28,13.898,94.48,15.044,,False,82.28,,neutral,,,,False,94.48,,neutral,,,neutral,,-0.2687,0.0222,-22.155,-2.93737178047625,0.6696040077831568,Uncertain,0.8597,pathogenic,-3.744,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S121V,NP_000537:p.Ser121Val,,,,,saturation_mutlist,,,,,,,,1.83437,0.4230961799621582,,1.0312572045097366,,1.4328136022548683,,Neutral,Neutral,,Neutral,0.33492610412075535,,0.2416781670196668,-0.05562,,0.26588579188748523,,0.10513289594374262,,Neutral,,Neutral,,0.45348433313027503,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3335,0.0222,-22.155,-7.22257451018822,0.8668198396912001,Pathogenic,0.9869,pathogenic,-4.25,available,https://doi.org/10.1101/2022.10.22.513328 +S121W,NP_000537:p.Ser121Trp,,,,,saturation_mutlist,,,,,,,,0.30266,0.1618304431438446,,-0.2300455926587365,,0.03630720367063174,,Neutral,Neutral,,Neutral,0.11618041177517972,,0.03944542682888555,-0.35739,,-0.5414360285475402,,-0.4494130142737701,,Neutral,,Neutral,,0.1014109381400877,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3658,0.0222,-22.155,-6.20863209751825,0.8624378634923795,Pathogenic,0.9743,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328 +S121Y,NP_000537:p.Ser121Tyr,"hg19,17:g.7579325G>T, hg19,17:g.7676007G>T, hg38,17:g.7676007G>T",,,0.921,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",4427947,,,,,,,-0.02521,0.17067018866539002,0.05793666666666667,-0.05133693370679463,0.016363333333333334,-0.03827346685339732,Neutral,Neutral,Neutral,Neutral,Neutral,0.11019224044850574,0.10608550963989172,0.12137705909710877,-0.46746,-0.5310666666666667,-0.13246424674833734,-0.49926333333333334,-0.29996212337416867,Neutral,Neutral,Neutral,Neutral,0.2998430239679126,0.06808159564038652,82.28,13.898,94.48,15.044,,False,82.28,,uncertain,,,,False,94.48,,uncertain,,,neutral,,-0.3609,0.0222,-22.155,-5.93163641213085,0.867154259992369,Pathogenic,0.977,pathogenic,-4.387,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V122A,NP_000537:p.Val122Ala,"hg19,17:g.7579322A>G, hg38,17:g.7676004A>G",,,0.650,"ClinVar,saturation_mutlist",1465964,Uncertain significance,2,,,,,0.42148,0.4874021100997925,1.4824266666666668,1.1341023534773809,0.9519533333333334,0.7777911767386905,Neutral,Neutral,Neutral,Neutral,Neutral,0.3579770545195043,0.19535853267489717,0.39344451889238813,-1.97387,1.5396866666666666,1.3224194230849535,-0.21709166666666668,-0.32572528845752324,Neutral,Neutral,Neutral,Neutral,0.27489104269793063,0.23883962681046503,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.1509,0.9804,-0.7004,-1.76350618499936,0.0027183795131928,Benign,0.7958,pathogenic,-3.23,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V122C,NP_000537:p.Val122Cys,,,,,saturation_mutlist,,,,,,,,0.45695,0.2377415132522583,,1.3755460744918813,,0.9162480372459406,,Neutral,Neutral,,Neutral,0.22441848040680923,,0.3672987972768804,-1.77013,,1.6397235737689628,,-0.06520321311551858,,Neutral,,Neutral,,0.194717789754939,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.2882,0.9804,-22.1581,-3.66496848799178,0.85979189287393,Pathogenic,0.9758,pathogenic,-4.11,available,https://doi.org/10.1101/2022.10.22.513328 +V122D,NP_000537:p.Val122Asp,,,,,saturation_mutlist,,,,,,,,1.17231,0.9889059340953827,,2.215273442870601,,1.6937917214353004,,Uncertain,Neutral,,Neutral,0.5296667576262971,,0.8188209671810921,-0.19116,,2.5927370878003306,,1.2007885439001653,,Uncertain,,Neutral,,0.5029725792847897,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.427,0.9804,-22.1581,-4.97407101704693,0.8539304849706768,Pathogenic,0.9947,pathogenic,-4.408,available,https://doi.org/10.1101/2022.10.22.513328 +V122E,NP_000537:p.Val122Glu,,,,,saturation_mutlist,,,,,,,,0.77886,0.8781134700775146,,2.0049837235037438,,1.3919218617518718,,Uncertain,Neutral,,Neutral,0.5055650385784247,,0.9632096745632626,0.6556,,2.6687497382196015,,1.6621748691098008,,Uncertain,,Neutral,,0.3692851735875579,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.3843,0.9804,-22.1581,-4.97407101704693,0.8669532001292661,Pathogenic,0.9809,pathogenic,-4.332,available,https://doi.org/10.1101/2022.10.22.513328 +V122F,NP_000537:p.Val122Phe,,,,,saturation_mutlist,,,,,,,,1.29765,0.7037328362464905,,0.9002021915425198,,1.0989260957712599,,Neutral,Neutral,,Neutral,0.4210736846512833,,0.8828789279096622,8.56248,,1.6488562272608285,,5.105668113630415,,Uncertain,,Destabilizing,,0.5155674753114741,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.3375,0.9804,-22.1581,-5.92997476481835,0.8671019742300847,Pathogenic,0.9381,pathogenic,-4.095,available,https://doi.org/10.1101/2022.10.22.513328 +V122G,NP_000537:p.Val122Gly,,,,,saturation_mutlist,,,,,,,,0.93285,1.0157311141490937,,2.411228642654031,,1.6720393213270155,,Uncertain,Uncertain,,Neutral,0.42678223796521486,,0.6399171634374,-1.82557,,2.3861702064108985,,0.2803001032054493,,Uncertain,,Neutral,,0.28746189924389914,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.3862,0.9804,-22.1581,-6.29330782092666,0.787640046476105,Pathogenic,0.9441,pathogenic,-4.074,available,https://doi.org/10.1101/2022.10.22.513328 +V122H,NP_000537:p.Val122His,,,,,saturation_mutlist,,,,,,,,1.9765,0.6740661597251892,,1.2324461280099408,,1.6044730640049703,,Neutral,Neutral,,Neutral,0.4551571726989713,,0.9813915840727352,6.82777,,1.8152926527256936,,4.321531326362847,,Uncertain,,Destabilizing,,0.44915093398904005,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.4299,0.9804,-22.1581,-5.92997476481835,0.7085672877222389,Pathogenic,0.9936,pathogenic,-4.276,available,https://doi.org/10.1101/2022.10.22.513328 +V122I,NP_000537:p.Val122Ile,,,,,saturation_mutlist,,,,,,,,0.3342,0.26784500122070315,,0.48888267622628606,,0.41154133811314303,,Neutral,Neutral,,Neutral,0.28890967947525437,,0.4917063356505949,0.83037,,1.2156475966993712,,1.0230087983496856,,Neutral,,Neutral,,0.27550094200738473,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.1959,0.9804,-22.1581,-3.67399170888624,0.1270954160997734,Benign,0.4737,ambiguous,-3.674,available,https://doi.org/10.1101/2022.10.22.513328 +V122K,NP_000537:p.Val122Lys,,,,,saturation_mutlist,,,,,,,,0.46929,0.7915027999877929,,1.7867613229350658,,1.1280256614675328,,Neutral,Neutral,,Neutral,0.49740778182733403,,1.2573116378126348,1.70036,,2.480588343707467,,2.0904741718537334,,Uncertain,,Uncertain,,0.5618238233373501,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.4232,0.9804,-22.1581,-4.97321975239921,0.7115895917646837,Pathogenic,0.9834,pathogenic,-4.03,available,https://doi.org/10.1101/2022.10.22.513328 +V122L,NP_000537:p.Val122Leu,"hg19,17:g.7579323C>A, hg38,17:g.7676005C>A",,,0.730,"COSMIC,ClinVar,saturation_mutlist",2121740,Uncertain significance,1,,,,,0.10866,0.43375428915023806,1.6178,0.5530554137422379,0.8632299999999999,0.33085770687111893,Neutral,Neutral,Neutral,Neutral,Neutral,0.31680019004084076,0.01844134485334518,0.7820648695051186,1.93484,1.3548766666666667,1.2127712631686907,1.6448583333333333,1.5738056315843454,Neutral,Neutral,Neutral,Neutral,0.7797475225709638,0.2809013339652829,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.1932,0.9804,-8.8702,-2.71835073884853,0.5879473918055794,Uncertain,0.9597,pathogenic,-3.609,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V122M,NP_000537:p.Val122Met,"hg19,17:g.7579323C>T, hg38,17:g.7676005C>T",,,0.770,"cBioPortal,ClinVar,saturation_mutlist",141101,Likely benign,3,,,,,0.08937,0.5108191084861755,1.5884333333333334,0.9562153109277185,0.8389016666666667,0.5227926554638592,Neutral,Neutral,Neutral,Neutral,Neutral,0.33244237681660527,0.3889500010998272,0.7703809994477433,0.1591,1.2268700000000001,1.390937888937825,0.6929850000000001,0.7750189444689125,Neutral,Neutral,Neutral,Neutral,1.517241340943051,0.2431114277634675,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.2701,0.9804,-22.1581,-3.60531022220006,0.5534714396146241,Uncertain,0.8281,pathogenic,-3.819,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V122N,NP_000537:p.Val122Asn,,,,,saturation_mutlist,,,,,,,,1.04804,0.8655485463142395,,1.4334181039845302,,1.2407290519922651,,Neutral,Neutral,,Neutral,0.4800138001948538,,0.7090900621760485,0.01409,,1.7880827257032472,,0.9010863628516236,,Neutral,,Neutral,,0.276879802252912,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.4148,0.9804,-22.1581,-3.63982935137633,0.1930178990821741,Benign,0.974,pathogenic,-3.949,available,https://doi.org/10.1101/2022.10.22.513328 +V122P,NP_000537:p.Val122Pro,,,,,saturation_mutlist,,,,,,,,1.4223,0.8250779116153717,,4.627166489350425,,3.0247332446752124,,Uncertain,Neutral,,Destabilizing,0.5841740094687448,,0.6532305175720216,0.96627,,5.923442448950023,,3.444856224475011,,Uncertain,,Destabilizing,,0.18925882116656775,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.4647,0.9804,-22.1581,-4.59805773752566,0.3002226023770185,Benign,0.9936,pathogenic,-3.954,available,https://doi.org/10.1101/2022.10.22.513328 +V122Q,NP_000537:p.Val122Gln,,,,,saturation_mutlist,,,,,,,,0.8136,0.6564727330207825,,1.4764249947716754,,1.1450124973858378,,Neutral,Neutral,,Neutral,0.48186895281903974,,0.767863644058884,0.59283,,2.0380919274217573,,1.3154609637108785,,Uncertain,,Neutral,,0.27059281311463623,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.3949,0.9804,-22.1581,-3.67916714786858,0.7490731174394698,Pathogenic,0.9496,pathogenic,-4.015,available,https://doi.org/10.1101/2022.10.22.513328 +V122R,NP_000537:p.Val122Arg,,,,,saturation_mutlist,,,,,,,,0.91917,0.8123493480682373,,1.2050105195072351,,1.0620902597536177,,Neutral,Neutral,,Neutral,0.4696284178406269,,1.0687383999181865,1.53999,,1.6644339254176659,,1.602211962708833,,Neutral,,Neutral,,0.4412974408609179,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.4442,0.9804,-22.1581,-5.1855809362478,0.624260275438607,Uncertain,0.9576,pathogenic,-4.179,available,https://doi.org/10.1101/2022.10.22.513328 +V122S,NP_000537:p.Val122Ser,,,,,saturation_mutlist,,,,,,,,0.81328,0.6647425150871277,,1.5251881138394225,,1.1692340569197113,,Neutral,Neutral,,Neutral,0.3983705363097976,,0.5953372659256416,-2.09769,,1.8099551182083486,,-0.1438674408958257,,Uncertain,,Neutral,,0.14571046815051641,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.364,0.9804,-22.1581,-2.95170511528338,0.5044674811243428,Uncertain,0.867,pathogenic,-3.766,available,https://doi.org/10.1101/2022.10.22.513328 +V122T,NP_000537:p.Val122Thr,,,,,saturation_mutlist,,,,,,,,0.54109,0.5013262867927551,,1.0937894104752086,,0.8174397052376043,,Neutral,Neutral,,Neutral,0.2792673845741245,,0.5147026401806056,-1.12569,,1.508212726082509,,0.1912613630412544,,Neutral,,Neutral,,0.18433411666318267,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.2794,0.9804,-22.1581,-2.3155515721326,0.1545036367206991,Benign,0.8814,pathogenic,-3.634,available,https://doi.org/10.1101/2022.10.22.513328 +V122W,NP_000537:p.Val122Trp,,,,,saturation_mutlist,,,,,,,,2.0206,0.7497649645805359,,0.9227556619359674,,1.4716778309679837,,Uncertain,Neutral,,Neutral,0.4395959345430781,,1.2314197925339694,9.97384,,1.6442187301170235,,5.809029365058511,,Uncertain,,Destabilizing,,0.6824273617712668,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.3781,0.9804,-22.1581,-5.92997476481835,0.8672802549628518,Pathogenic,0.9988,pathogenic,-4.506,available,https://doi.org/10.1101/2022.10.22.513328 +V122Y,NP_000537:p.Val122Tyr,,,,,saturation_mutlist,,,,,,,,1.84397,0.7652897548675537,,1.119783172848634,,1.481876586424317,,Neutral,Neutral,,Neutral,0.4630300083632227,,1.0314775563211631,9.75263,,1.93317782235463,,5.842903911177315,,Uncertain,,Destabilizing,,0.6578994965969567,30.468,13.892,12.755,5.404,,False,30.468,,neutral,neutral,neutral,,False,12.755,,neutral,neutral,neutral,uncertain,,-0.381,0.9804,-22.1581,-4.62999008249986,0.8695452723611845,Pathogenic,0.9925,pathogenic,-4.191,available,https://doi.org/10.1101/2022.10.22.513328 +T123A,NP_000537:p.Thr123Ala,,,,,saturation_mutlist,,,,,,,,-0.37626,0.518203673362732,,0.2750224651266033,,-0.05061876743669835,,Neutral,Neutral,,Neutral,0.19919950656531227,,0.11128371754268322,-1.04337,,0.1783790524739072,,-0.43249547376304637,,Neutral,,Neutral,,0.05286279705223907,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.2998,0.2461,-22.1612,-1.41306825243521,0.3841325060514203,Uncertain,0.4842,ambiguous,-3.608,available,https://doi.org/10.1101/2022.10.22.513328 +T123C,NP_000537:p.Thr123Cys,,,,,saturation_mutlist,,,,,,,,-0.1398,0.21503405570983886,,0.7365770991761438,,0.29838854958807187,,Neutral,Neutral,,Neutral,0.11746450604420265,,0.07916971153377442,-0.48116,,0.6133299999969407,,0.06608499999847037,,Neutral,,Neutral,,0.05770221352563513,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.3356,0.2461,-22.1612,-4.21812374764703,0.8640373324656396,Pathogenic,0.8758,pathogenic,-4.162,available,https://doi.org/10.1101/2022.10.22.513328 +T123D,NP_000537:p.Thr123Asp,,,,,saturation_mutlist,,,,,,,,0.32463,0.46439637660980226,,0.10735860222019888,,0.21599430111009943,,Neutral,Neutral,,Neutral,0.2260248588821558,,0.1787076723150357,-1.00982,,-0.0496085079799406,,-0.5297142539899703,,Neutral,,Neutral,,0.134286243567512,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.4153,0.2461,-22.1612,-4.22874243016215,0.5229433035074851,Uncertain,0.9735,pathogenic,-3.944,available,https://doi.org/10.1101/2022.10.22.513328 +T123E,NP_000537:p.Thr123Glu,,,,,saturation_mutlist,,,,,,,,-0.76653,0.4772392797470093,,0.05408018161276636,,-0.3562249091936168,,Neutral,Neutral,,Neutral,0.2310779938433806,,0.16858569699683218,-0.86577,,-0.00033413043686903826,,-0.43305206521843453,,Neutral,,Neutral,,0.05040320663736054,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.3907,0.2461,-22.1612,-5.28283851591469,0.776163550631777,Pathogenic,0.96,pathogenic,-4.128,available,https://doi.org/10.1101/2022.10.22.513328 +T123F,NP_000537:p.Thr123Phe,,,,,saturation_mutlist,,,,,,,,-0.45648,0.5395116877555847,,-0.5249057999503601,,-0.49069289997518006,,Neutral,Neutral,,Neutral,0.14487404040911572,,0.1764989061168503,-0.71673,,-0.23277027171091777,,-0.4747501358554589,,Neutral,,Neutral,,0.14087532528288066,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.407,0.2461,-22.1612,-4.29300010611783,0.783502131792862,Pathogenic,0.8463,pathogenic,-4.222,available,https://doi.org/10.1101/2022.10.22.513328 +T123G,NP_000537:p.Thr123Gly,,,,,saturation_mutlist,,,,,,,,0.14805,0.6672670602798462,,0.8689895055813238,,0.5085197527906619,,Neutral,Neutral,,Neutral,0.21373141414997904,,0.15977587151955977,-2.34797,,0.8187631671897098,,-0.7646034164051452,,Uncertain,,Neutral,,0.24880527746756745,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.3732,0.2461,-22.1612,-5.98280747713691,0.6319014439985808,Uncertain,0.7888,pathogenic,-3.979,available,https://doi.org/10.1101/2022.10.22.513328 +T123H,NP_000537:p.Thr123His,,,,,saturation_mutlist,,,,,,,,0.10234,0.4626086020469666,,-0.3837376340710091,,-0.14069881703550455,,Neutral,Neutral,,Neutral,0.13868301040034103,,0.14591343701677953,-0.20916,,-0.3017269509994928,,-0.25544347549974644,,Neutral,,Neutral,,0.04330158670761335,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.3873,0.2461,-22.1612,-4.86123686648965,0.4012280187108658,Uncertain,0.8737,pathogenic,-3.864,available,https://doi.org/10.1101/2022.10.22.513328 +T123I,NP_000537:p.Thr123Ile,"hg19,17:g.7579319G>A, hg38,17:g.7676001G>A",,,0.859,"COSMIC,ClinVar,saturation_mutlist",480737,Uncertain significance,2,,,,,-0.24521,0.427774031162262,0.9733533333333334,-0.09750119879214443,0.3640716666666667,-0.17135559939607223,Neutral,Neutral,Neutral,Neutral,Neutral,0.26307749219266424,0.5000545286488487,0.1607909294299908,-0.13208,0.2672366666666667,-0.18815409102200267,0.06757833333333334,-0.16011704551100134,Neutral,Neutral,Neutral,Neutral,0.6358571917935312,0.1984272541880149,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.2498,0.2461,-7.2884,-3.81089778015391,0.5781656728163203,Uncertain,0.7275,pathogenic,-3.844,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T123K,NP_000537:p.Thr123Lys,,,,,saturation_mutlist,,,,,,,,-0.79963,0.6483150768280029,,-0.03548715845003806,,-0.417558579225019,,Neutral,Neutral,,Neutral,0.17752243987142816,,0.09868010001779028,-0.96439,,0.06344896226062617,,-0.4504705188696869,,Neutral,,Neutral,,0.019862181683559604,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.3829,0.2461,-22.1612,-5.66172147520125,0.6914001769176373,Pathogenic,0.9036,pathogenic,-3.811,available,https://doi.org/10.1101/2022.10.22.513328 +T123L,NP_000537:p.Thr123Leu,,,,,saturation_mutlist,,,,,,,,-0.71219,0.501933970451355,,-0.5595092453107574,,-0.6358496226553787,,Neutral,Neutral,,Neutral,0.19291860598313937,,0.1349506173269911,-0.99611,,-0.5064984311853102,,-0.7513042155926551,,Neutral,,Neutral,,0.06600744429821175,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.3098,0.2461,-8.8733,-4.37161777354302,0.760879372013092,Pathogenic,0.3986,ambiguous,-4.012,available,https://doi.org/10.1101/2022.10.22.513328 +T123M,NP_000537:p.Thr123Met,,,,,saturation_mutlist,,,,,,,,-0.72299,0.5989907169342041,,-0.08199242464966451,,-0.40249121232483226,,Neutral,Neutral,,Neutral,0.1819116820194846,,0.16105722336585707,-1.20922,,-0.17767642590634303,,-0.6934482129531715,,Neutral,,Neutral,,0.07582979975659447,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.2614,0.2461,-5.8734,-2.12802621584502,0.2717357429090354,Benign,0.2237,benign,-3.614,available,https://doi.org/10.1101/2022.10.22.513328 +T123N,NP_000537:p.Thr123Asn,,,,,saturation_mutlist,,,,,,,,-0.10352,0.4256781816482544,,-0.03540313730232763,,-0.06946156865116382,,Neutral,Neutral,,Neutral,0.18253306057971336,,0.10019148210200304,-0.68759,,-0.14201198546322968,,-0.41480099273161486,,Neutral,,Neutral,,0.09665220658249875,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.3554,0.2461,-22.1612,-4.24343325547966,0.1095035712778922,Benign,0.6684,pathogenic,-3.69,available,https://doi.org/10.1101/2022.10.22.513328 +T123P,NP_000537:p.Thr123Pro,,,,,saturation_mutlist,,,,,,,,-0.93938,0.7307536315917968,,1.6689364959049913,,0.36477824795249564,,Neutral,Neutral,,Neutral,0.42865714174454833,,0.5349883243049399,-1.9062,,1.1428196827774009,,-0.3816901586112995,,Neutral,,Neutral,,0.327105179850632,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.4641,0.2461,-22.1612,-4.40214612507321,0.0409553553751071,Benign,0.5174,ambiguous,-3.789,available,https://doi.org/10.1101/2022.10.22.513328 +T123Q,NP_000537:p.Thr123Gln,,,,,saturation_mutlist,,,,,,,,-0.53659,0.5932484602928162,,0.14458440644544082,,-0.1960027967772796,,Neutral,Neutral,,Neutral,0.16182722618101636,,0.11539388090196417,-0.55816,,0.10825479250584391,,-0.22495260374707804,,Neutral,,Neutral,,0.04277846388563267,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.3648,0.2461,-22.1612,-4.11064328734141,0.3018638569533626,Benign,0.7822,pathogenic,-3.767,available,https://doi.org/10.1101/2022.10.22.513328 +T123R,NP_000537:p.Thr123Arg,,,,,saturation_mutlist,,,,,,,,-0.42124,0.6810828399658203,,-0.29535173810156523,,-0.3582958690507826,,Neutral,Neutral,,Neutral,0.1827231502342761,,0.0386044971241282,-0.80356,,-0.18762297231234215,,-0.4955914861561711,,Neutral,,Neutral,,0.042134715257716476,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.3179,0.2461,-8.8733,-4.71948159874475,0.8401218435465783,Pathogenic,0.8629,pathogenic,-4.111,available,https://doi.org/10.1101/2022.10.22.513328 +T123S,NP_000537:p.Thr123Ser,"hg19,17:g.7579319G>C, hg38,17:g.7676001G>C",,,0.729,"ClinVar,saturation_mutlist",1460570,Uncertain significance,1,,,,,-0.01379,0.16008620738983154,0.45,0.3443417645646301,0.218105,0.16527588228231505,Neutral,Neutral,Neutral,Neutral,Neutral,0.15021617961682124,0.19376027473831334,0.07214640806882223,-0.6831,0.47279,0.17135917912988793,-0.10515500000000003,-0.25587041043505604,Neutral,Neutral,Neutral,Neutral,0.29363264748094114,0.12602221328378674,37.718,8.947,31.685,11.228,,False,37.718,,neutral,,,,False,31.685,,neutral,,,uncertain,,-0.2635,0.2461,-22.1612,-2.83100541577873,0.0431761108684732,Benign,0.5218,ambiguous,-3.47,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T123V,NP_000537:p.Thr123Val,,,,,saturation_mutlist,,,,,,,,-0.16965,0.40568588018417356,,-0.0643051855468585,,-0.11697759277342926,,Neutral,Neutral,,Neutral,0.22639491701320566,,0.11969860901225622,-0.02754,,-0.08483902081576439,,-0.05618951040788219,,Neutral,,Neutral,,0.17302066319942377,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.2454,0.2461,-8.8733,-4.78053029742989,0.4171463292270749,Uncertain,0.5358,ambiguous,-3.721,available,https://doi.org/10.1101/2022.10.22.513328 +T123W,NP_000537:p.Thr123Trp,,,,,saturation_mutlist,,,,,,,,0.07907,0.3668241047859192,,-0.8937085339059575,,-0.40731926695297876,,Neutral,Neutral,,Neutral,0.2252529940939827,,0.23197747762620843,-0.34373,,-0.5340924671465483,,-0.43891123357327416,,Neutral,,Neutral,,0.1470823447827256,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.3999,0.2461,-22.1612,-5.66312143111933,0.8643231461347172,Pathogenic,0.9634,pathogenic,-4.44,available,https://doi.org/10.1101/2022.10.22.513328 +T123Y,NP_000537:p.Thr123Tyr,,,,,saturation_mutlist,,,,,,,,-0.39357,0.437806282043457,,-0.4169194948457477,,-0.40524474742287386,,Neutral,Neutral,,Neutral,0.1930444238717999,,0.14622559379910863,-0.55378,,-0.10918017013485437,,-0.3314800850674272,,Neutral,,Neutral,,0.0837136909769083,37.718,8.947,31.685,11.228,,False,37.718,,uncertain,,,,False,31.685,,uncertain,,,uncertain,,-0.4085,0.2461,-22.1612,-4.31933104992387,0.856271009791606,Pathogenic,0.9199,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328 +C124A,NP_000537:p.Cys124Ala,,,,,saturation_mutlist,,,,,,,,0.42676,0.5612081336975098,,0.5536793531342993,,0.4902196765671496,,Neutral,Neutral,,Neutral,0.15432509099858366,,0.10711478959133387,-0.38428,,0.495146027602543,,0.0554330138012715,,Neutral,,Neutral,,0.33622484692565696,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,uncertain,,-0.289,1.4701,-8.8733,-2.18183009910751,0.8160872185967706,Pathogenic,0.718,pathogenic,-3.762,available,https://doi.org/10.1101/2022.10.22.513328 +C124D,NP_000537:p.Cys124Asp,,,,,saturation_mutlist,,,,,,,,2.16604,1.510872983932495,,2.169596784650695,,2.167818392325348,,Uncertain,Uncertain,,Uncertain,0.39267986472766897,,0.3598429179503793,4.09472,,1.8210633517978188,,2.9578916758989093,,Uncertain,,Uncertain,,0.1091152056464753,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,uncertain,,-0.4641,1.4701,-22.1612,-5.27984144218348,0.860821369238431,Pathogenic,0.9838,pathogenic,-4.321,available,https://doi.org/10.1101/2022.10.22.513328 +C124E,NP_000537:p.Cys124Glu,,,,,saturation_mutlist,,,,,,,,2.27507,1.589758005142212,,2.073194191108119,,2.1741320955540595,,Uncertain,Uncertain,,Uncertain,0.31789662006210334,,0.28915813833683723,5.23391,,1.5809044080524288,,3.407407204026214,,Uncertain,,Destabilizing,,0.2260277794956078,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.4517,1.4701,-22.1612,-5.27984144218348,0.7866239890922151,Pathogenic,0.9944,pathogenic,-4.346,available,https://doi.org/10.1101/2022.10.22.513328 +C124F,NP_000537:p.Cys124Phe,"hg38,17:g.7675998C>A",,,0.792,"COSMIC,saturation_mutlist",,,,,,,,2.06278,-0.09356015682220459,1.4163266666666667,-0.20822726896894536,1.7395533333333333,0.9272763655155274,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.3248059039026265,1.706850032005025,0.8980687192815541,14.49033,3.281633333333333,0.6466124988270975,8.885981666666666,7.568471249413549,Destabilizing,Uncertain,Destabilizing,Destabilizing,1.9963500296680328,0.32184321480073264,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.283,1.4701,-8.8733,-1.9121478721896,0.0473841459919966,Benign,0.4765,ambiguous,-3.543,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C124G,NP_000537:p.Cys124Gly,"hg19,17:g.7579317A>C, hg19,17:g.7675999A>C, hg38,17:g.7675999A>C",,,0.843,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",230661,Uncertain significance,1,,,,,1.50225,1.4799819278717041,2.57506,2.3072999720781895,2.0386550000000003,1.9047749860390948,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.32662772490103603,0.4939893515721433,0.38430982831790383,0.14789,2.5481866666666666,2.4391535262818103,1.3480383333333332,1.293521763140905,Uncertain,Uncertain,Neutral,Neutral,0.7166918376509918,0.38114381814225107,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,uncertain,,-0.2815,1.4701,-8.8733,-5.88245089714293,0.7125230884979975,Pathogenic,0.5754,pathogenic,-4.017,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C124H,NP_000537:p.Cys124His,,,,,saturation_mutlist,,,,,,,,2.02917,0.8414766836166382,,0.7944753779038972,,1.4118226889519487,,Uncertain,Neutral,,Neutral,0.3072146005639657,,0.624657472535703,11.46352,,1.1640378679176229,,6.313778933958812,,Uncertain,,Destabilizing,,0.22297124142152094,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.4626,1.4701,-22.1612,-2.80385490296217,0.6416064908619981,Uncertain,0.915,pathogenic,-4.064,available,https://doi.org/10.1101/2022.10.22.513328 +C124I,NP_000537:p.Cys124Ile,,,,,saturation_mutlist,,,,,,,,0.72131,0.13628320455551146,,-0.34777529527361145,,0.18676735236319428,,Neutral,Neutral,,Neutral,0.30222359139187804,,0.11484242708590145,2.74098,,-0.5672100817742579,,1.086884959112871,,Uncertain,,Neutral,,0.24007807887795454,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.3807,1.4701,-22.1612,-3.53666427597966,0.7701531978091749,Pathogenic,0.9129,pathogenic,-4.085,available,https://doi.org/10.1101/2022.10.22.513328 +C124K,NP_000537:p.Cys124Lys,,,,,saturation_mutlist,,,,,,,,1.49482,1.6583142828941346,,2.471112756308905,,1.9829663781544524,,Uncertain,Uncertain,,Neutral,0.3468635534245688,,0.9465132498379023,6.42094,,3.1904436205743707,,4.805691810287185,,Destabilizing,,Destabilizing,,0.5664248228490819,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.4523,1.4701,-22.1612,-4.19743582472115,0.784172275961019,Pathogenic,0.9973,pathogenic,-4.214,available,https://doi.org/10.1101/2022.10.22.513328 +C124L,NP_000537:p.Cys124Leu,"hg19,17:g.7579315_7579316delinsTA, hg38,17:g.7675997_7675998delinsTA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.15342,0.618164529800415,2.4786866666666665,-0.3911593270291485,1.3160533333333333,-0.11886966351457426,Uncertain,Neutral,Neutral,Neutral,Neutral,0.3391482058177277,0.9155606800328542,0.31168816989711956,3.054,1.7503400000000002,-0.5868540872133663,2.40217,1.2335729563933167,Uncertain,Uncertain,Uncertain,Neutral,0.7321741193641488,0.30808263674856795,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.4138,1.4701,-22.1612,-3.54227661798402,0.3612036954452436,Uncertain,0.8639,pathogenic,-3.874,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C124M,NP_000537:p.Cys124Met,,,,,saturation_mutlist,,,,,,,,-0.80893,0.41313872098922727,,0.18761208799937293,,-0.31065895600031357,,Neutral,Neutral,,Neutral,0.22212429939055373,,0.44676557461299643,3.39258,,0.20735061172208322,,1.7999653058610416,,Uncertain,,Neutral,,0.2673778912409405,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.381,1.4701,-22.1612,-3.5719436773238,0.7726735272983916,Pathogenic,0.8807,pathogenic,-4.148,available,https://doi.org/10.1101/2022.10.22.513328 +C124N,NP_000537:p.Cys124Asn,,,,,saturation_mutlist,,,,,,,,1.15627,1.3632737684249878,,1.000762675682716,,1.078516337841358,,Neutral,Uncertain,,Neutral,0.37379008954109916,,0.23286376372289638,3.47354,,0.7163871289397825,,2.094963564469891,,Uncertain,,Uncertain,,0.11964299405031965,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.3387,1.4701,-8.8733,-3.98283563887645,0.2525232163193669,Benign,0.8774,pathogenic,-3.758,available,https://doi.org/10.1101/2022.10.22.513328 +C124P,NP_000537:p.Cys124Pro,,,,,saturation_mutlist,,,,,,,,2.84589,1.663016176223755,,4.689022384488026,,3.767456192244013,,Uncertain,Uncertain,,Destabilizing,0.2662690974644294,,0.9180738890518463,0.00016,,4.566333443334386,,2.2832467216671932,,Uncertain,,Uncertain,,0.806376169501016,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,uncertain,,-0.4752,1.4701,-22.1612,-5.88245089714293,0.7901626306381831,Pathogenic,0.9959,pathogenic,-4.26,available,https://doi.org/10.1101/2022.10.22.513328 +C124Q,NP_000537:p.Cys124Gln,,,,,saturation_mutlist,,,,,,,,1.48294,1.1659881973266601,,1.0521156814608559,,1.2675278407304278,,Neutral,Uncertain,,Neutral,0.3019122240856719,,0.20870117056176915,5.53024,,1.141325627004875,,3.3357828135024374,,Uncertain,,Destabilizing,,0.35883601432420176,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.4305,1.4701,-22.1612,-4.03048259172124,0.787906315637342,Pathogenic,0.9756,pathogenic,-4.188,available,https://doi.org/10.1101/2022.10.22.513328 +C124R,NP_000537:p.Cys124Arg,"hg19,17:g.7579317A>G, hg19,17:g.7675999A>G, hg38,17:g.7675999A>G",,,0.883,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",4056245,Likely pathogenic,1,,,,,3.40308,1.6254651045799255,5.06984,1.4759102363727195,4.23646,2.43949511818636,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,0.3485332354212593,1.9538694787011746,0.8165104843841527,11.5456,6.443993333333334,2.2993868476171886,8.994796666666668,6.922493423808595,Destabilizing,Uncertain,Destabilizing,Destabilizing,1.1510815785840531,0.4196756699999044,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.4091,1.4701,-22.1612,-5.29044806310019,0.7677302688161243,Pathogenic,0.9764,pathogenic,-4.037,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C124S,NP_000537:p.Cys124Ser,"hg19,17:g.7579316C>G, hg19,17:g.7579317A>T, hg38,17:g.7675998C>G, hg38,17:g.7675999A>T",3.1843077315e-05,7.9729557341e-06,"0.668, 0.716","COSMIC,ClinVar,ClinVar,saturation_mutlist","1021578, 182926","Uncertain significance, Likely benign","1, 3",,,,,0.88032,0.5672679090499878,1.49195,1.3880337841901271,1.1861350000000002,1.1341768920950637,Neutral,Neutral,Neutral,Neutral,Neutral,0.18910734771914461,0.22082774931304863,0.3446438613486489,0.47955,1.40941,1.4811109332322951,0.94448,0.9803304666161475,Neutral,Neutral,Neutral,Neutral,0.11012152045202914,0.2826005967286145,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,uncertain,,-0.2506,1.4701,-3.1455,-1.74552172632798,7.137384591964712e-05,Benign,0.4372,ambiguous,-3.314,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C124T,NP_000537:p.Cys124Thr,,,,,saturation_mutlist,,,,,,,,0.74435,0.5589725017547608,,0.5286158911659922,,0.6364829455829961,,Neutral,Neutral,,Neutral,0.2618910549851906,,0.19009216918779603,1.21706,,0.5272278170388107,,0.8721439085194054,,Neutral,,Neutral,,0.2740248288580343,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.3823,1.4701,-22.1612,-3.84241840855199,0.4406528805342293,Uncertain,0.7823,pathogenic,-3.884,available,https://doi.org/10.1101/2022.10.22.513328 +C124V,NP_000537:p.Cys124Val,,,,,saturation_mutlist,,,,,,,,0.35983,-0.027235429286956787,,-0.3556369828923492,,0.002096508553825399,,Neutral,Neutral,,Neutral,0.3117156774150785,,0.1568261689694073,1.32507,,-0.6025129765008714,,0.36127851174956427,,Neutral,,Neutral,,0.3230955756542487,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.3788,1.4701,-22.1612,-3.48435045668782,0.5519396039363752,Uncertain,0.7651,pathogenic,-3.656,available,https://doi.org/10.1101/2022.10.22.513328 +C124W,NP_000537:p.Cys124Trp,"hg19,17:g.7579315G>C, hg38,17:g.7675997G>C",,,0.537,"ClinVar,saturation_mutlist",3809674,Likely benign,1,,,,,5.6304,-0.2729544854164124,5.117913333333334,0.7953651353562142,5.374156666666667,3.212882567678107,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,0.6021922717865359,2.2127672279197275,1.40313702703111,23.10774,5.90238,1.7954034168174697,14.50506,12.451571708408736,Destabilizing,Uncertain,Destabilizing,Destabilizing,2.897395537938627,0.7693333253014484,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.2445,1.4701,-0.7186,-0.067669720157014,0.0038011747740692,Benign,0.7055,pathogenic,-3.194,available,https://doi.org/10.1101/2022.10.22.513328 +C124Y,NP_000537:p.Cys124Tyr,"hg19,17:g.7579316C>T, hg38,17:g.7675998C>T",,,0.713,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,3.42956,0.0022796010971069336,3.1800466666666662,0.4094826607331263,3.304803333333333,1.919521330366563,Destabilizing,Uncertain,Neutral,Destabilizing,Neutral,0.4181045456331657,2.514578011109529,1.0557610979175545,18.29257,6.838549999999999,1.5948777091994444,12.56556,9.943723854599723,Destabilizing,Uncertain,Destabilizing,Destabilizing,5.757514547163559,0.5040329598180482,7.518,7.071,0.27,0.508,,True,7.518,,neutral,neutral,neutral,,True,0.27,,neutral,neutral,neutral,neutral,,-0.277,1.4701,-5.8734,-1.02496409689317,5.185731656250633e-05,Benign,0.6263,pathogenic,-3.316,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125A,NP_000537:p.Thr125Ala,"hg19,17:g.7579314T>C, hg19,17:g.7675996T>C, hg38,17:g.7675996T>C",,,0.943,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1734453,Uncertain significance,2,,,Tier I - Strong,1,1.5058,0.5636487221717834,0.7709733333333334,0.31096227608579347,1.1383866666666667,0.9083811380428968,Neutral,Neutral,Neutral,Neutral,Neutral,0.2296622920005844,0.511753696898116,0.054785180487386856,-0.37242,0.5719933333333334,0.461404533557544,0.09978666666666669,0.04449226677877202,Neutral,Neutral,Neutral,Neutral,0.38350102949304093,0.192163589455622,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,damaging,,-0.3143,0.088,-22.1612,-3.69569381712477,0.3888783576341865,Uncertain,0.9598,pathogenic,-3.757,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125C,NP_000537:p.Thr125Cys,,,,,saturation_mutlist,,,,,,,,1.06844,-0.0035467720031738237,,0.8044875495067564,,0.9364637747533782,,Neutral,Neutral,,Neutral,0.25267688720443127,,0.0983989936537872,-0.51707,,0.5072374972390011,,-0.004916251380499448,,Neutral,,Neutral,,0.1925466290096627,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,damaging,,-0.3501,0.088,-22.1612,-4.44543292242316,0.8446299161327433,Pathogenic,0.9876,pathogenic,-4.015,available,https://doi.org/10.1101/2022.10.22.513328 +T125D,NP_000537:p.Thr125Asp,,,,,saturation_mutlist,,,,,,,,2.638,1.2637834668159484,,1.1769072685942934,,1.9074536342971466,,Uncertain,Uncertain,,Neutral,0.4111317722432404,,0.3716231070435125,0.32464,,1.2259919212258017,,0.7753159606129009,,Neutral,,Neutral,,0.1377149687372563,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,uncertain,,-0.4299,0.088,-22.1612,-5.72277290666319,0.7500211912927643,Pathogenic,0.9926,pathogenic,-4.222,available,https://doi.org/10.1101/2022.10.22.513328 +T125E,NP_000537:p.Thr125Glu,,,,,saturation_mutlist,,,,,,,,3.43576,0.9131805992126465,,1.3055014697611906,,2.3706307348805953,,Uncertain,Neutral,,Uncertain,0.47735889355841427,,0.7524932965009343,0.76766,,1.1413205118634533,,0.9544902559317266,,Neutral,,Neutral,,0.21543837187464943,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,neutral,,-0.4052,0.088,-22.1612,-4.27110981250882,0.0790193522187552,Benign,0.9907,pathogenic,-3.946,available,https://doi.org/10.1101/2022.10.22.513328 +T125F,NP_000537:p.Thr125Phe,,,,,saturation_mutlist,,,,,,,,8.60564,0.3115356755256653,,0.1981719732284782,,4.4019059866142385,,Uncertain,Neutral,,Destabilizing,0.4110949263354608,,0.5022464875876429,8.67672,,-0.029882453025630012,,4.323418773487185,,Uncertain,,Destabilizing,,0.40982778328154407,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,neutral,,-0.4215,0.088,-22.1612,-5.99876483395326,0.7456579303036063,Pathogenic,0.99,pathogenic,-3.93,available,https://doi.org/10.1101/2022.10.22.513328 +T125G,NP_000537:p.Thr125Gly,,,,,saturation_mutlist,,,,,,,,2.70944,1.386329391002655,,1.524066825749452,,2.116753412874726,,Uncertain,Uncertain,,Uncertain,0.31117693857219686,,0.16166183170356677,0.78313,,2.1454311885769006,,1.4642805942884503,,Uncertain,,Neutral,,0.1661639422516921,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,damaging,,-0.3878,0.088,-22.1612,-5.58781602161766,0.6538406828478669,Uncertain,0.9735,pathogenic,-4.236,available,https://doi.org/10.1101/2022.10.22.513328 +T125H,NP_000537:p.Thr125His,,,,,saturation_mutlist,,,,,,,,7.52509,0.6170726656913758,,0.458026589273512,,3.991558294636756,,Uncertain,Neutral,,Destabilizing,0.35321735667761184,,0.37211676745086303,7.72345,,0.4705795342862719,,4.097014767143135,,Uncertain,,Destabilizing,,0.22493008298978712,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,neutral,,-0.4018,0.088,-22.1612,-4.8024143711309,0.7653469485409383,Pathogenic,0.9905,pathogenic,-4.098,available,https://doi.org/10.1101/2022.10.22.513328 +T125I,NP_000537:p.Thr125Ile,"hg19,17:g.7579312_7579313delinsGA",,,,"cBioPortal,saturation_mutlist",,,,,,,,1.43596,-0.3907617473602295,1.489,-0.015348512878126108,1.46248,0.7103057435609369,Neutral,Neutral,Neutral,Neutral,Neutral,0.3312816758479365,0.8206067350442598,0.5127402694065625,-0.19693,1.05431,-0.6338789981906942,0.42869,-0.41540449909534705,Neutral,Neutral,Neutral,Neutral,1.4973072083131993,0.4851061956922302,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,neutral,,-0.3402,0.088,-22.1612,-5.00501852348552,0.2630039935626909,Benign,0.9893,pathogenic,-3.684,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125K,NP_000537:p.Thr125Lys,"hg19,17:g.7579313G>T, hg19,17:g.7675995G>T, hg38,17:g.7675995G>T",,,0.963,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",216465,Pathogenic,2,,,,,4.88883,1.0535407912731172,6.10476,1.1575611894574391,5.496795,3.0231955947287195,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.4433312183919803,0.4437957721745445,0.7201100145969201,3.53393,7.649886666666667,1.3016694667997473,5.5919083333333335,2.4177997333998738,Destabilizing,Uncertain,Destabilizing,Uncertain,1.207436209393919,0.269179593277388,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,neutral,,-0.3974,0.088,-22.1612,-2.4608657686824,0.6053490660459484,Uncertain,0.9893,pathogenic,-3.985,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125L,NP_000537:p.Thr125Leu,,,,,saturation_mutlist,,,,,,,,1.40209,0.28851701974868776,,-0.2176636537492771,,0.5922131731253615,,Neutral,Neutral,,Neutral,0.40614544738360175,,0.672649256517826,0.59533,,-0.6104703211141381,,-0.00757016055706905,,Neutral,,Neutral,,0.39077068567237566,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,neutral,,-0.3921,0.088,-22.1612,-2.58079320149291,0.1985671836638807,Benign,0.9686,pathogenic,-3.811,available,https://doi.org/10.1101/2022.10.22.513328 +T125M,NP_000537:p.Thr125Met,"hg19,17:g.7579313G>A, hg19,17:g.7675995G>A, hg38,17:g.7675995G>A",3.1847133758e-05,,0.925,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",183748,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,Tier I - Strong,1,1.25207,0.22170894384384154,2.1612233333333335,0.19663528870003996,1.7066466666666669,0.72435264435002,Uncertain,Neutral,Neutral,Neutral,Neutral,0.35986293301086697,1.0756001718213988,0.6324530592596571,0.39173,2.6481866666666667,-0.09540248289972782,1.5199583333333333,0.1481637585501361,Uncertain,Neutral,Neutral,Neutral,0.9170826689865835,0.30830326407981595,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,neutral,,-0.2913,0.088,-8.8733,-3.69157310336068,0.0017308159673534,Benign,0.9602,pathogenic,-3.54,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125N,NP_000537:p.Thr125Asn,"hg19,17:g.7579312_7579313delinsAT, hg19,17:g.7579312_7579313delinsGT",,,,"cBioPortal,saturation_mutlist",,,,,,,,2.42682,1.069636688232422,2.4089566666666666,0.5728760229123705,2.4178883333333334,1.4998480114561854,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.3148204399049132,0.5732956117823412,0.2295109079565006,0.43704,1.41066,0.39252734306339004,0.9238500000000001,0.41478367153169504,Neutral,Neutral,Neutral,Neutral,0.029098289755012562,0.11880904065495611,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,uncertain,,-0.3699,0.088,-22.1612,-3.73799870025625,0.7962314885829296,Pathogenic,0.9794,pathogenic,-4.031,available,https://doi.org/10.1101/2022.10.22.513328 +T125P,NP_000537:p.Thr125Pro,"hg19,17:g.7579314T>G, hg19,17:g.7675996T>G, hg38,17:g.7675996T>G",,,0.945,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376666,Conflicting classifications of pathogenicity,1,,,,,3.96314,1.8948029947280884,4.914966666666666,5.093010492580056,4.439053333333333,4.528075246290028,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.32171135930432926,1.2045236781769333,1.1081364891445225,2.33575,4.437416666666667,4.011419790285473,3.3865833333333333,3.1735848951427363,Uncertain,Uncertain,Destabilizing,Destabilizing,2.6432999102678876,0.7683341105026915,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,uncertain,,-0.4786,0.088,-22.1612,-5.32216348223569,0.8309450404478289,Pathogenic,0.9855,pathogenic,-4.306,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125Q,NP_000537:p.Thr125Gln,,,,,saturation_mutlist,,,,,,,,3.31828,0.7335662758350372,,0.8886672045294303,,2.103473602264715,,Uncertain,Neutral,,Uncertain,0.35995201316213427,,0.5783718418069758,1.93479,,0.5251775919168139,,1.229983795958407,,Neutral,,Neutral,,0.1687155291349738,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,neutral,,-0.3116,0.088,-8.8733,-3.03746157648101,0.2547190630195928,Benign,0.9775,pathogenic,-4.031,available,https://doi.org/10.1101/2022.10.22.513328 +T125R,NP_000537:p.Thr125Arg,"hg19,17:g.7579313G>C, hg19,17:g.7675995G>C, hg38,17:g.7675995G>C",,,0.963,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376667,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,7.51574,0.8087074851989746,6.049093333333334,0.5210751151490114,6.782416666666667,4.0184075575745055,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,0.3525336094106704,1.4486292467325408,0.7659903709861815,5.55374,9.016436666666666,0.6670851210157102,7.2850883333333325,3.1104125605078554,Destabilizing,Uncertain,Destabilizing,Destabilizing,4.67700289536888,0.27937981147887875,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,neutral,,-0.3324,0.088,-8.8733,-5.1784825919015,0.7645356027603756,Pathogenic,0.9823,pathogenic,-4.109,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125S,NP_000537:p.Thr125Ser,"hg19,17:g.7579314T>A, hg38,17:g.7675996T>A",,,0.903,"ClinVar,saturation_mutlist",4427945,,,,,,,0.96642,0.30479551911354064,,0.7788195070795849,,0.8726197535397924,,Neutral,Neutral,,Neutral,0.19598891339637362,,0.07710051693828886,0.49658,,1.0547730212149027,,0.7756765106074514,,Neutral,,Neutral,,0.0494305926257009,4.495,5.269,1.7,2.139,,True,4.495,,neutral,,,,True,1.7,,neutral,,,damaging,,-0.278,0.088,-22.1612,-3.08982050013961,0.3440417979530826,Uncertain,0.9221,pathogenic,-3.654,available,https://doi.org/10.1101/2022.10.22.513328 +T125V,NP_000537:p.Thr125Val,,,,,saturation_mutlist,,,,,,,,0.58432,-0.3691638422012329,,-0.1678972432094409,,0.20821137839527953,,Neutral,Neutral,,Neutral,0.27602721514542755,,0.1293951279107608,-1.4762,,-0.6718766500152946,,-1.0740383250076473,,Neutral,,Neutral,,0.45749712588733027,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,neutral,,-0.2599,0.088,-8.8733,-4.17323637168827,0.0704061521294842,Benign,0.9546,pathogenic,-3.56,available,https://doi.org/10.1101/2022.10.22.513328 +T125W,NP_000537:p.Thr125Trp,,,,,saturation_mutlist,,,,,,,,13.31869,-0.020385031700134285,,-0.08908303219611631,,6.614803483901942,,Uncertain,Neutral,,Destabilizing,0.4016825634478684,,0.7147514579190595,14.60102,,0.2011432864094328,,7.401081643204717,,Uncertain,,Destabilizing,,0.26564798272704593,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,neutral,,-0.4144,0.088,-22.1612,-4.8590119543022,0.8073752894993366,Pathogenic,0.9964,pathogenic,-4.458,available,https://doi.org/10.1101/2022.10.22.513328 +T125Y,NP_000537:p.Thr125Tyr,,,,,saturation_mutlist,,,,,,,,12.0187,0.1936492943763733,,0.38277512242215234,,6.200737561211077,,Uncertain,Neutral,,Destabilizing,0.41869901693067696,,0.5413286828643367,11.15225,,0.4685254098634814,,5.810387704931741,,Uncertain,,Destabilizing,,0.3140972400813621,4.495,5.269,1.7,2.139,,True,4.495,,uncertain,,,,True,1.7,,uncertain,,,neutral,,-0.423,0.088,-22.1612,-6.30296732646816,0.783155000924346,Pathogenic,0.9938,pathogenic,-4.187,available,https://doi.org/10.1101/2022.10.22.513328 +Y126A,NP_000537:p.Tyr126Ala,,,,,saturation_mutlist,,,,,,,,3.29793,2.5709323930740355,,3.2691175003224697,,3.283523750161235,,Destabilizing,Destabilizing,,Destabilizing,0.3942253648953361,,0.3836331114006409,-0.19171,,2.8143473549805234,,1.3113186774902617,,Uncertain,,Neutral,,0.40082236433114066,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,damaging,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.4268,0.2714,-22.1946,-7.66884365354854,0.8707919740838916,Pathogenic,0.9931,pathogenic,-4.397,available,https://doi.org/10.1101/2022.10.22.513328 +Y126C,NP_000537:p.Tyr126Cys,"hg19,17:g.7578553T>C, hg19,17:g.7675235T>C, hg38,17:g.7675235T>C",,,0.981,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458541,Conflicting classifications of pathogenicity,1,Oncogenic,1,Tier II - Potential,1,2.86646,1.7310044479370117,3.3637200000000003,3.7438727905611024,3.1150900000000004,3.3051663952805512,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.4204313182588195,0.38504958226181735,0.2557774309078471,-0.06205,2.27415,3.013775052587216,1.10605,1.4758625262936078,Uncertain,Uncertain,Neutral,Neutral,0.8245602712153106,0.323590943686787,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,uncertain,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.3975,0.2714,-22.1946,-7.66884365354854,0.8062403036546579,Pathogenic,0.8716,pathogenic,-4.087,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y126D,NP_000537:p.Tyr126Asp,"hg19,17:g.7578554A>C, hg19,17:g.7675236A>C, hg38,17:g.7675236A>C",,,0.979,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",265333,Conflicting classifications of pathogenicity,1,,,,,4.17442,3.1813055896759033,5.14875,4.433797696087389,4.661585,4.304108848043694,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.3063142169626905,0.1799837816767573,0.4764140058805275,0.55699,4.261793333333333,4.036674015095346,2.4093916666666666,2.296832007547673,Uncertain,Uncertain,Uncertain,Uncertain,0.09034349057286245,0.47617629148380913,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,damaging,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.441,0.2714,-22.1946,-7.66884365354854,0.8633179175907857,Pathogenic,0.995,pathogenic,-4.587,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y126E,NP_000537:p.Tyr126Glu,,,,,saturation_mutlist,,,,,,,,3.43699,2.910198450088501,,3.8870880601290256,,3.6620390300645127,,Destabilizing,Destabilizing,,Destabilizing,0.3815253436360369,,0.3454502455811068,0.42585,,3.66203078248344,,2.04394039124172,,Uncertain,,Uncertain,,0.4635005328356577,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,damaging,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.4698,0.2714,-22.1946,-7.66884365354854,0.8707285738620218,Pathogenic,0.9985,pathogenic,-4.538,available,https://doi.org/10.1101/2022.10.22.513328 +Y126F,NP_000537:p.Tyr126Phe,,,,,saturation_mutlist,,,,,,,,-0.20552,0.23479201316833495,,0.4594935986823006,,0.1269867993411503,,Neutral,Neutral,,Neutral,0.18700228335223515,,0.1491105213001078,-0.57401,,0.5476002413816013,,-0.013204879309199336,,Neutral,,Neutral,,0.3671557089331511,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,neutral,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.1745,0.2714,-4.585,-2.13386744275084,0.0002772515298761,Benign,0.1219,benign,-3.15,available,https://doi.org/10.1101/2022.10.22.513328 +Y126G,NP_000537:p.Tyr126Gly,,,,,saturation_mutlist,,,,,,,,4.51728,2.9514689445495605,,4.940577849484444,,4.728928924742222,,Destabilizing,Destabilizing,,Destabilizing,0.23450863102362976,,0.3648998891757578,-0.00488,,4.287957397041553,,2.1415386985207765,,Uncertain,,Uncertain,,0.5201053296582775,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,damaging,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.4974,0.2714,-22.1946,-7.66884365354854,0.8620416934555737,Pathogenic,0.9882,pathogenic,-4.604,available,https://doi.org/10.1101/2022.10.22.513328 +Y126H,NP_000537:p.Tyr126His,"hg19,17:g.7578554A>G, hg19,17:g.7675236A>G, hg38,17:g.7675236A>G",,,0.961,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1734755,Conflicting classifications of pathogenicity,1,,,,,2.74204,2.0198574924468993,2.7061233333333337,2.1453264745479057,2.7240816666666667,2.4436832372739525,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,0.23935298205348213,0.20184743088668616,0.1703450861038735,1.11364,1.5265300000000002,2.041417678800776,1.3200850000000002,1.577528839400388,Neutral,Uncertain,Neutral,Neutral,0.7082138686865713,0.176042183665379,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,uncertain,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.3346,0.2714,-22.1946,-2.81945396308076,0.6359628940776968,Uncertain,0.9448,pathogenic,-3.986,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y126I,NP_000537:p.Tyr126Ile,,,,,saturation_mutlist,,,,,,,,2.08026,1.7551263856887818,,2.2330954639338345,,2.1566777319669175,,Uncertain,Uncertain,,Uncertain,0.5743696209922002,,0.12459635488601871,-0.2245,,1.9544019619361706,,0.8649509809680853,,Neutral,,Neutral,,0.3094103623757935,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,uncertain,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.4389,0.2714,-22.1946,-6.81430827383659,0.8700703019115622,Pathogenic,0.9676,pathogenic,-4.286,available,https://doi.org/10.1101/2022.10.22.513328 +Y126K,NP_000537:p.Tyr126Lys,,,,,saturation_mutlist,,,,,,,,2.52495,2.701740846633911,,3.7784176194841854,,3.1516838097420927,,Uncertain,Destabilizing,,Destabilizing,0.36265819368306146,,0.5143205244823077,0.37414,,3.2134995913267264,,1.7938197956633632,,Uncertain,,Neutral,,0.3824048124077787,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,uncertain,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.495,0.2714,-22.1946,-7.66884365354854,0.8514969873727171,Pathogenic,0.9984,pathogenic,-4.563,available,https://doi.org/10.1101/2022.10.22.513328 +Y126L,NP_000537:p.Tyr126Leu,"hg19,17:g.7578553_7578554delinsAG, hg38,17:g.7675235_7675236delinsAG",,,,"ClinVar,saturation_mutlist",2687703,Uncertain significance,0,,,,,1.10788,1.6528273916244507,,1.813640068749977,,1.4607600343749885,,Neutral,Uncertain,,Neutral,0.5329052410098787,,0.06748583058441399,-0.4431,,1.3913149647960008,,0.4741074823980004,,Neutral,,Neutral,,0.15916387453647343,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,neutral,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.416,0.2714,-22.1946,-6.81430827383659,0.870614235976073,Pathogenic,0.9741,pathogenic,-4.136,available,https://doi.org/10.1101/2022.10.22.513328 +Y126M,NP_000537:p.Tyr126Met,,,,,saturation_mutlist,,,,,,,,0.56063,1.8385116481781005,,2.033431013475781,,1.2970305067378907,,Uncertain,Uncertain,,Neutral,0.4672602617002741,,0.1501606381467221,-1.02206,,1.7770383655594657,,0.37748918277973287,,Neutral,,Neutral,,0.26261315028479326,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,neutral,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.3681,0.2714,-22.1946,-6.57122346242208,0.6680354864778459,Uncertain,0.9839,pathogenic,-4.146,available,https://doi.org/10.1101/2022.10.22.513328 +Y126N,NP_000537:p.Tyr126Asn,"hg19,17:g.7578554A>T, hg19,17:g.7675236A>T, hg38,17:g.7675236A>T",,,0.965,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428871,Conflicting classifications of pathogenicity,1,,,,,3.12953,2.8551707744598387,4.03061,3.340382099904017,3.58007,3.2349560499520083,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.2672343593338064,0.17411323346221183,0.4170355214268886,0.56624,2.521546666666666,2.878496715283324,1.5438933333333331,1.722368357641662,Uncertain,Uncertain,Neutral,Neutral,0.12000066897961678,0.2844962822815022,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,damaging,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.42,0.2714,-22.1946,-7.66884365354854,0.8703495188167917,Pathogenic,0.9806,pathogenic,-4.474,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y126P,NP_000537:p.Tyr126Pro,,,,,saturation_mutlist,,,,,,,,4.07997,2.6854144954681396,,7.603311046422493,,5.841640523211247,,Destabilizing,Destabilizing,,Destabilizing,0.2503792517391392,,0.4252344469834043,-0.15368,,6.14254708656233,,2.9944335432811653,,Uncertain,,Uncertain,,0.79468300541506,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,damaging,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.551,0.2714,-22.1946,-7.66884365354854,0.8708548471750946,Pathogenic,0.9978,pathogenic,-4.517,available,https://doi.org/10.1101/2022.10.22.513328 +Y126Q,NP_000537:p.Tyr126Gln,,,,,saturation_mutlist,,,,,,,,3.09119,2.696171236038208,,3.2574358783729918,,3.174312939186496,,Destabilizing,Destabilizing,,Destabilizing,0.35409355009435206,,0.41053805678919025,0.33018,,2.907947627770751,,1.6190638138853755,,Uncertain,,Neutral,,0.349400704472064,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,damaging,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.4446,0.2714,-22.1946,-7.66884365354854,0.8699805938501821,Pathogenic,0.9972,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +Y126R,NP_000537:p.Tyr126Arg,,,,,saturation_mutlist,,,,,,,,3.02269,2.521026134490967,,2.9945801845662956,,3.0086350922831477,,Uncertain,Destabilizing,,Destabilizing,0.30384097475121163,,0.3637009926978443,0.49808,,2.450085571433558,,1.4740827857167789,,Uncertain,,Neutral,,0.4397015201812032,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,damaging,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.4904,0.2714,-22.1946,-7.66884365354854,0.8683791636644766,Pathogenic,0.9915,pathogenic,-4.43,available,https://doi.org/10.1101/2022.10.22.513328 +Y126S,NP_000537:p.Tyr126Ser,"hg19,17:g.7578553T>G, hg19,17:g.7675235T>G, hg38,17:g.7675235T>G",,,0.972,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1054765,Uncertain significance,1,,,,,4.12205,2.7637438011169433,4.48424,4.1729391807079645,4.303145,4.147494590353983,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.36042394391353977,0.1642092031525637,0.377019598934319,0.75038,2.908053333333333,3.5295076430915557,1.8292166666666665,2.139943821545778,Uncertain,Uncertain,Neutral,Uncertain,0.6752477377641154,0.46233122788598424,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,damaging,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.4316,0.2714,-22.1946,-7.66884365354854,0.870552189184163,Pathogenic,0.97,pathogenic,-4.328,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y126T,NP_000537:p.Tyr126Thr,,,,,saturation_mutlist,,,,,,,,3.22,2.537005276679993,,3.412867811991276,,3.316433905995638,,Destabilizing,Destabilizing,,Destabilizing,0.38631945982698196,,0.26903753246447715,0.8042,,2.8047781940053707,,1.8044890970026852,,Uncertain,,Neutral,,0.47596226282270965,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,damaging,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.4502,0.2714,-22.1946,-7.66884365354854,0.8706299985965237,Pathogenic,0.9914,pathogenic,-4.341,available,https://doi.org/10.1101/2022.10.22.513328 +Y126V,NP_000537:p.Tyr126Val,,,,,saturation_mutlist,,,,,,,,2.1183,1.765041151046753,,2.4476173234556824,,2.2829586617278412,,Uncertain,Uncertain,,Uncertain,0.5092838027353702,,0.16620757229724933,-0.06513,,2.0784411375045715,,1.0066555687522858,,Uncertain,,Neutral,,0.4393822639723812,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,uncertain,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.3606,0.2714,-8.9068,-5.01499849535105,0.8238197302987403,Pathogenic,0.9201,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328 +Y126W,NP_000537:p.Tyr126Trp,,,,,saturation_mutlist,,,,,,,,0.28259,0.3529976844787598,,0.801938951736182,,0.542264475868091,,Neutral,Neutral,,Neutral,0.21608073412334364,,0.044705764864589416,0.10237,,0.8114951667019819,,0.4569325833509909,,Neutral,,Neutral,,0.2552450049652118,21.948,7.86,22.23,7.687,P,True,21.948,-0.156,uncertain,neutral,uncertain,P,True,22.23,-0.405,uncertain,neutral,uncertain,uncertain,,-0.3444,0.2714,-22.1946,-3.82078055238846,0.6037018315182043,Uncertain,0.5503,ambiguous,-4.003,available,https://doi.org/10.1101/2022.10.22.513328 +S127A,NP_000537:p.Ser127Ala,,,,,saturation_mutlist,,,,,,,,0.20256,1.694205927848816,,-0.11800464798584799,,0.042277676007076,,Neutral,Uncertain,,Neutral,0.16618946957258726,,0.2617452996379069,-0.24525,,-0.6164084666490447,,-0.43082923332452233,,Neutral,,Neutral,,0.09451772674787659,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.2803,0.0001,-22.1976,-3.98743337199207,0.7575090431417312,Pathogenic,0.7237,pathogenic,-4.024,available,https://doi.org/10.1101/2022.10.22.513328 +S127C,NP_000537:p.Ser127Cys,"hg19,17:g.7578550G>C, hg19,17:g.7675232G>C, hg38,17:g.7675232G>C",,,0.916,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",219532,Pathogenic,1,,,,,0.63569,1.3749852228164672,-0.22199666666666665,0.5771538798892294,0.20684666666666668,0.6064219399446147,Neutral,Neutral,Uncertain,Neutral,Neutral,0.1695876878221769,0.13794023158197496,0.2881321523949429,-0.36542,-0.41122,0.23245576317075875,-0.38832,-0.06648211841462064,Neutral,Neutral,Neutral,Neutral,0.46222337334525465,0.2599332382335589,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3307,0.0001,-22.1976,-4.84694629009541,0.870643929777644,Pathogenic,0.8325,pathogenic,-4.26,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S127D,NP_000537:p.Ser127Asp,,,,,saturation_mutlist,,,,,,,,4.07085,1.1553476810455323,,2.264301514319192,,3.1675757571595957,,Uncertain,Uncertain,,Destabilizing,0.32389394791845116,,0.5338057624056051,1.157,,0.5321895652632004,,0.8445947826316003,,Neutral,,Neutral,,0.4749619874831148,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3789,0.0001,-22.1976,-6.01309484017505,0.2845681608281866,Benign,0.9841,pathogenic,-4.194,available,https://doi.org/10.1101/2022.10.22.513328 +S127E,NP_000537:p.Ser127Glu,,,,,saturation_mutlist,,,,,,,,7.01536,2.6234457206726076,,3.1151869250251045,,5.065273462512552,,Destabilizing,Destabilizing,,Destabilizing,0.26606083987834866,,0.8734094540712964,1.98306,,0.3284960412115172,,1.1557780206057586,,Neutral,,Neutral,,0.5663890817860248,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3521,0.0001,-22.1976,-6.92087321066688,0.8707941460512538,Pathogenic,0.9927,pathogenic,-4.599,available,https://doi.org/10.1101/2022.10.22.513328 +S127F,NP_000537:p.Ser127Phe,"hg19,17:g.7578549_7578550delinsAA, hg19,17:g.7578550G>A, hg19,17:g.7675232G>A, hg38,17:g.7675231_7675232delinsAA, hg38,17:g.7675232G>A",,,0.925,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182928,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,11.27279,2.1580494356155397,4.402496666666667,2.94081772293636,7.837643333333334,7.1068038614681805,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.2026900400973704,2.2400300373184483,1.4843153602904664,0.01289,1.6128133333333334,-0.7412933730455785,0.8128516666666668,-0.3642016865227893,Neutral,Neutral,Neutral,Neutral,0.540670590306355,0.5641811307058849,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3583,0.0001,-22.1976,-8.07108885348846,0.8698991360516073,Pathogenic,0.9947,pathogenic,-4.348,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S127G,NP_000537:p.Ser127Gly,,,,,saturation_mutlist,,,,,,,,1.4431,2.283769826889038,,1.3545192866162428,,1.3988096433081214,,Neutral,Destabilizing,,Neutral,0.1875544989049485,,0.19469995778971638,0.18169,,0.9257429158262559,,0.553716457913128,,Neutral,,Neutral,,0.3042974209859333,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.2894,0.0001,-22.1976,-8.07108885348846,0.8706598438544537,Pathogenic,0.9187,pathogenic,-4.212,available,https://doi.org/10.1101/2022.10.22.513328 +S127H,NP_000537:p.Ser127His,,,,,saturation_mutlist,,,,,,,,17.03908,1.934849624633789,,2.9991125498242996,,10.01909627491215,,Uncertain,Uncertain,,Destabilizing,0.25064647496041786,,1.2614651398510963,2.62667,,-0.3023243237178748,,1.1621728381410625,,Uncertain,,Neutral,,0.41326764454447057,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3595,0.0001,-22.1976,-8.07108885348846,0.8406018380310666,Pathogenic,0.9673,pathogenic,-4.372,available,https://doi.org/10.1101/2022.10.22.513328 +S127I,NP_000537:p.Ser127Ile,,,,,saturation_mutlist,,,,,,,,1.9487,1.8810958862304688,,1.5579585066096773,,1.7533292533048388,,Neutral,Uncertain,,Neutral,0.2743826400727817,,1.2060832689339405,1.36414,,-0.28826491407370264,,0.5379375429631487,,Neutral,,Neutral,,0.5445872311076063,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3615,0.0001,-22.1976,-7.80031783887452,0.8651133257022714,Pathogenic,0.9853,pathogenic,-4.481,available,https://doi.org/10.1101/2022.10.22.513328 +S127K,NP_000537:p.Ser127Lys,,,,,saturation_mutlist,,,,,,,,7.14307,2.212736587524414,,5.134251414893841,,6.13866070744692,,Destabilizing,Destabilizing,,Destabilizing,0.18501574414879957,,1.7046608325957233,1.06877,,0.8143466953141495,,0.9415583476570748,,Neutral,,Neutral,,0.7842148909614254,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3689,0.0001,-22.1976,-8.07108885348846,0.8708636637510747,Pathogenic,0.999,pathogenic,-4.518,available,https://doi.org/10.1101/2022.10.22.513328 +S127L,NP_000537:p.Ser127Leu,,,,,saturation_mutlist,,,,,,,,2.72618,2.224334969520569,,1.5433024398354416,,2.1347412199177205,,Uncertain,Destabilizing,,Uncertain,0.2261707557500835,,1.2323171469813206,-0.89753,,-1.015981937469188,,-0.9567559687345941,,Neutral,,Neutral,,0.423835645038089,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3577,0.0001,-22.1976,-7.80031783887452,0.8250715177987141,Pathogenic,0.9614,pathogenic,-4.31,available,https://doi.org/10.1101/2022.10.22.513328 +S127M,NP_000537:p.Ser127Met,,,,,saturation_mutlist,,,,,,,,3.45171,2.0261941814422606,,1.7834521458685142,,2.6175810729342572,,Uncertain,Destabilizing,,Uncertain,0.18105192652643376,,1.0365686862283097,-1.65685,,-0.7284114552841424,,-1.1926307276420711,,Neutral,,Neutral,,0.29223035542470016,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3288,0.0001,-22.1976,-7.80031783887452,0.8699827092321264,Pathogenic,0.9874,pathogenic,-4.493,available,https://doi.org/10.1101/2022.10.22.513328 +S127N,NP_000537:p.Ser127Asn,,,,,saturation_mutlist,,,,,,,,3.77045,0.7185612630844116,,1.060877325468453,,2.4156636627342265,,Uncertain,Neutral,,Uncertain,0.2648651938210518,,0.5526159892329798,0.69257,,-0.10192187510655464,,0.2953240624467227,,Neutral,,Neutral,,0.2547224363378575,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3026,0.0001,-22.1976,-6.13697492139391,0.5822820018070793,Uncertain,0.9739,pathogenic,-4.016,available,https://doi.org/10.1101/2022.10.22.513328 +S127P,NP_000537:p.Ser127Pro,"hg19,17:g.7578551A>G, hg19,17:g.7675233A>G, hg38,17:g.7675233A>G",,,0.957,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",934410,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,2.82674,2.6488664293289186,3.8521533333333333,5.709204999612877,3.3394466666666665,4.267972499806438,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.4342227390826354,1.2584124233687815,1.1897931331065057,4.44205,1.884126666666667,6.2334558522877215,3.1630883333333335,5.33775292614386,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.5819562310193287,1.3822224535863028,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.4337,0.0001,-22.1976,-8.07108885348846,0.8697375221032067,Pathogenic,0.9962,pathogenic,-4.434,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S127Q,NP_000537:p.Ser127Gln,,,,,saturation_mutlist,,,,,,,,6.13214,2.28222620010376,,2.3155351699962505,,4.223837584998125,,Uncertain,Destabilizing,,Destabilizing,0.20490090348014128,,0.8615907087595784,0.74393,,-0.15308455269535334,,0.2954227236523233,,Neutral,,Neutral,,0.43002476658746264,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3222,0.0001,-22.1976,-6.92087321066688,0.8706441933789701,Pathogenic,0.9913,pathogenic,-4.455,available,https://doi.org/10.1101/2022.10.22.513328 +S127R,NP_000537:p.Ser127Arg,,,,,saturation_mutlist,,,,,,,,8.33185,1.92790611743927,,4.159368649404421,,6.24560932470221,,Destabilizing,Uncertain,,Destabilizing,0.19504245686076715,,1.638579692249948,2.40726,,-0.07785345961207131,,1.1647032701939644,,Uncertain,,Neutral,,0.5308652494882652,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3741,0.0001,-22.1976,-8.07108885348846,0.8551222037805941,Pathogenic,0.9975,pathogenic,-4.486,available,https://doi.org/10.1101/2022.10.22.513328 +S127T,NP_000537:p.Ser127Thr,"hg19,17:g.7578551A>T, hg19,17:g.7675233A>T, hg38,17:g.7675233A>T",,,0.924,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",824232,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,1.52434,1.4029014348983764,0.27721,0.6628887834216405,0.900775,1.0936143917108203,Neutral,Neutral,Uncertain,Neutral,Neutral,0.1657732424726678,0.41000971069801095,0.519126688970254,0.79849,-0.05838666666666668,0.1302968063134142,0.37005166666666667,0.46439340315670713,Neutral,Neutral,Neutral,Neutral,0.3849648786000556,0.37377820067016987,0.055,0.444,5.555,5.104,,True,0.055,,neutral,,,,True,5.555,,neutral,,,uncertain,,-0.2709,0.0001,-22.1976,-4.84694629009541,0.8687933864095387,Pathogenic,0.8718,pathogenic,-4.155,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S127V,NP_000537:p.Ser127Val,,,,,saturation_mutlist,,,,,,,,0.99962,2.0774018478393557,,0.2706645906748068,,0.6351422953374034,,Neutral,Destabilizing,,Neutral,0.3030259569253573,,0.603824902665698,-0.44553,,-0.38796104459264696,,-0.41674552229632345,,Neutral,,Neutral,,0.4559570538526762,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3357,0.0001,-22.1976,-7.66191715368437,0.6193876770612399,Uncertain,0.977,pathogenic,-4.348,available,https://doi.org/10.1101/2022.10.22.513328 +S127W,NP_000537:p.Ser127Trp,,,,,saturation_mutlist,,,,,,,,19.62657,2.3956590127944946,,4.171926430892774,,11.899248215446388,,Destabilizing,Destabilizing,,Destabilizing,0.23548762825823347,,1.5238824777864552,3.71821,,-0.5960610735171176,,1.5610744632414413,,Uncertain,,Neutral,,0.9683878477931993,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.368,0.0001,-22.1976,-8.07108885348846,0.8609536105872804,Pathogenic,0.9882,pathogenic,-4.515,available,https://doi.org/10.1101/2022.10.22.513328 +S127Y,NP_000537:p.Ser127Tyr,"hg19,17:g.7578550G>T, hg19,17:g.7675232G>T, hg38,17:g.7675232G>T",,,0.918,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",656751,Pathogenic,3,,,,,14.19332,2.515770034790039,3.2331066666666666,3.795087196751112,8.713213333333334,8.994203598375556,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.26609634523517434,1.1914405824136687,1.5970452992441673,1.94147,2.6908166666666666,-0.29141961131668154,2.316143333333333,0.8250251943416592,Uncertain,Neutral,Uncertain,Neutral,1.7004025331341073,0.6671549698953535,0.055,0.444,5.555,5.104,,True,0.055,,uncertain,,,,True,5.555,,uncertain,,,uncertain,,-0.3631,0.0001,-22.1976,-8.07108885348846,0.8176478921805082,Pathogenic,0.9839,pathogenic,-4.41,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P128A,NP_000537:p.Pro128Ala,"hg19,17:g.7578548G>C, hg38,17:g.7675230G>C",,,0.482,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.40828,0.15068747997283935,0.77041,-0.3567227611273395,1.089345,0.5257786194363302,Neutral,Neutral,Neutral,Neutral,Neutral,0.14261302509796778,0.15668852946743314,0.17740086437381583,1.39993,1.3107733333333333,0.08755254771107705,1.3553516666666665,0.7437412738555385,Neutral,Neutral,Neutral,Neutral,0.09943637910186036,0.1495944962092579,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.0883,1.774,-7.3249,-1.54778559425076,0.0278393472842647,Benign,0.0757,benign,-3.248,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P128C,NP_000537:p.Pro128Cys,,,,,saturation_mutlist,,,,,,,,1.48817,-0.03037027359008789,,0.5593787363859147,,1.0237743681929574,,Neutral,Neutral,,Neutral,0.2087330828174897,,0.17061281138064024,1.78414,,0.7718202904361605,,1.2779801452180803,,Neutral,,Neutral,,0.11378971531270157,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.1969,1.774,-22.1976,-3.34305849144024,0.6127975669813828,Uncertain,0.384,ambiguous,-4.118,available,https://doi.org/10.1101/2022.10.22.513328 +P128D,NP_000537:p.Pro128Asp,,,,,saturation_mutlist,,,,,,,,1.31153,0.27465004682540894,,-0.40836748508690973,,0.4515812574565452,,Neutral,Neutral,,Neutral,0.18754138520783706,,0.3545995220906031,1.07926,,-0.27321094478739666,,0.4030245276063017,,Neutral,,Neutral,,0.08243633942908346,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.2228,1.774,-22.1976,-2.9566424783071,0.1379546080351052,Benign,0.3015,benign,-3.758,available,https://doi.org/10.1101/2022.10.22.513328 +P128E,NP_000537:p.Pro128Glu,,,,,saturation_mutlist,,,,,,,,1.14114,0.05623805046081543,,-0.5936336401708717,,0.27375317991456416,,Neutral,Neutral,,Neutral,0.17610607469635373,,0.31766677982256103,0.98787,,-0.34184988605267913,,0.3230100569736605,,Neutral,,Neutral,,0.11553954897915723,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.1131,1.774,-3.8655,-2.23479724546625,0.000587454165503,Benign,0.1674,benign,-3.48,available,https://doi.org/10.1101/2022.10.22.513328 +P128F,NP_000537:p.Pro128Phe,"hg19,17:g.7578547_7578548delinsAA",,,,"cBioPortal,saturation_mutlist",,,,,,,,1.00727,0.17830193042755127,0.7692733333333334,-0.8347909671678669,0.8882716666666668,0.08623951641606659,Neutral,Neutral,Neutral,Neutral,Neutral,0.29804126890359833,0.34017227021352314,0.14823988238719576,1.46517,1.52052,-0.33510896585111727,1.492845,0.5650305170744414,Neutral,Neutral,Neutral,Neutral,0.5454271150208798,0.17118757970542017,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.1575,1.774,-8.9098,-2.62455036394329,0.1079855609629131,Benign,0.4162,ambiguous,-4.019,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P128G,NP_000537:p.Pro128Gly,,,,,saturation_mutlist,,,,,,,,1.5585,0.44905746579170225,,0.41776239015617395,,0.988131195078087,,Neutral,Neutral,,Neutral,0.18291894185910848,,0.2869740082768709,1.54742,,0.4971023088084389,,1.0222611544042195,,Neutral,,Neutral,,0.034881237448877736,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.1786,1.774,-22.1976,-4.76465887426189,0.314696838701294,Benign,0.2599,benign,-3.76,available,https://doi.org/10.1101/2022.10.22.513328 +P128H,NP_000537:p.Pro128His,,,,,saturation_mutlist,,,,,,,,1.6217,0.1435808777809143,,-0.8142404368980847,,0.4037297815509576,,Neutral,Neutral,,Neutral,0.24426157781511024,,0.21937830201873054,1.82923,,-0.44559243632379825,,0.6918187818381009,,Neutral,,Neutral,,0.1467833076564586,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.203,1.774,-22.1976,-3.79622659352549,0.2813891507537747,Benign,0.155,benign,-3.721,available,https://doi.org/10.1101/2022.10.22.513328 +P128I,NP_000537:p.Pro128Ile,,,,,saturation_mutlist,,,,,,,,1.63995,0.15204185962677003,,-0.4940274335201826,,0.5729612832399087,,Neutral,Neutral,,Neutral,0.24479555879668166,,0.1933201675302205,1.87288,,-0.10282516113186609,,0.885027419434067,,Neutral,,Neutral,,0.18632448170265797,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.1355,1.774,-7.9098,-1.26387329687304,0.4247784895544457,Uncertain,0.2671,benign,-3.908,available,https://doi.org/10.1101/2022.10.22.513328 +P128K,NP_000537:p.Pro128Lys,,,,,saturation_mutlist,,,,,,,,1.04944,0.1806707525253296,,-0.45688769118392175,,0.2962761544080391,,Neutral,Neutral,,Neutral,0.18348500201790116,,0.22196130986460622,1.36678,,-0.1962273987460705,,0.5852763006269648,,Neutral,,Neutral,,0.11215890264194674,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.1203,1.774,-6.9099,-2.97411237015459,0.0024823352041268,Benign,0.2082,benign,-3.474,available,https://doi.org/10.1101/2022.10.22.513328 +P128L,NP_000537:p.Pro128Leu,"hg19,17:g.7578547G>A, hg38,17:g.7675229G>A",,,0.501,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",824286,Uncertain significance,2,,,,,1.06127,0.14289211750030517,0.94739,-0.8706335659703105,1.00433,0.09531821701484472,Neutral,Neutral,Neutral,Neutral,Neutral,0.23875440460583774,0.19882101297398114,0.06169003039790861,1.33598,1.0706333333333333,-0.45064522728604534,1.2033066666666667,0.44266738635697733,Neutral,Neutral,Neutral,Neutral,0.12078369821940195,0.20628902854266676,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.135,1.774,-6.9099,-2.31336388121896,0.0123665832504997,Benign,0.1109,benign,-3.627,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P128M,NP_000537:p.Pro128Met,,,,,saturation_mutlist,,,,,,,,0.96511,0.20724968910217284,,-0.5829328615125008,,0.19108856924374962,,Neutral,Neutral,,Neutral,0.19463353829575042,,0.11889045103753318,1.38927,,-0.10470298269095663,,0.6422835086545217,,Neutral,,Neutral,,0.19839614105862047,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.1639,1.774,-22.1976,-4.15791931399236,0.7481108312588328,Pathogenic,0.2683,benign,-3.983,available,https://doi.org/10.1101/2022.10.22.513328 +P128N,NP_000537:p.Pro128Asn,,,,,saturation_mutlist,,,,,,,,1.51263,0.2734520411491394,,-0.3170296141557094,,0.5978001929221453,,Neutral,Neutral,,Neutral,0.21320675632348948,,0.15951723655137315,1.47724,,-0.1417969982002017,,0.6677215008998992,,Neutral,,Neutral,,0.17438715856843495,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.191,1.774,-22.1976,-3.37887820333769,0.2612679035161364,Benign,0.2561,benign,-3.728,available,https://doi.org/10.1101/2022.10.22.513328 +P128Q,NP_000537:p.Pro128Gln,,,,,saturation_mutlist,,,,,,,,1.29185,0.13519662618637085,,-0.267373255335781,,0.5122383723321094,,Neutral,Neutral,,Neutral,0.15561131571066467,,0.23536855628409395,1.44287,,0.012243220196759228,,0.7275566100983797,,Neutral,,Neutral,,0.12528311251243734,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.1168,1.774,-7.3249,-2.22888658639592,0.012598301691919,Benign,0.1312,benign,-3.45,available,https://doi.org/10.1101/2022.10.22.513328 +P128R,NP_000537:p.Pro128Arg,"hg19,17:g.7578547G>C, hg38,17:g.7675229G>C",,,0.560,"ClinVar,saturation_mutlist",1718564,Conflicting classifications of pathogenicity,1,,,,,1.20379,0.25993030309677123,1.0397933333333333,-0.6157552153914766,1.1217916666666667,0.29401739230426166,Neutral,Neutral,Neutral,Neutral,Neutral,0.20343616657511943,0.1406483409863843,0.21043067736963603,1.48304,1.2250566666666667,-0.25650945090099275,1.3540483333333333,0.6132652745495035,Neutral,Neutral,Neutral,Neutral,0.45099767658923573,0.16792650286396316,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.2341,1.774,-22.1976,-4.46718637714041,0.1982005216964232,Benign,0.1368,benign,-3.764,available,https://doi.org/10.1101/2022.10.22.513328 +P128S,NP_000537:p.Pro128Ser,"hg19,17:g.7578548G>A, hg19,17:g.7675230G>A, hg38,17:g.7675230G>A",,,0.516,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2687698,Uncertain significance,0,,,,,1.47367,0.11604052543640135,0.8151933333333333,-0.2666894779555657,1.1444316666666667,0.6034902610222171,Neutral,Neutral,Neutral,Neutral,Neutral,0.14791016981482957,0.15743942778802972,0.2709804425295155,1.45607,0.9501133333333334,-0.0244843997107783,1.2030916666666667,0.7157928001446109,Neutral,Neutral,Neutral,Neutral,0.10858883746602231,0.046155610694966175,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.08,1.774,-5.74,-0.552517416553064,0.0007823254991297,Benign,0.1068,benign,-3.11,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P128T,NP_000537:p.Pro128Thr,"hg19,17:g.7578548G>T, hg38,17:g.7675230G>T",,,0.457,"ClinVar,saturation_mutlist",480743,Conflicting classifications of pathogenicity,1,,,,,1.83034,0.10290983676910401,1.0214299999999998,-0.27174592282689813,1.425885,0.779297038586551,Neutral,Neutral,Neutral,Neutral,Neutral,0.23709064078724384,0.19968850459319554,0.23673997521597942,2.03383,0.9590733333333334,-0.05795229927163157,1.4964516666666667,0.9879388503641843,Uncertain,Uncertain,Neutral,Neutral,0.20101150370618653,0.10382904125476568,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.0688,1.774,-1.182,-1.64287482783618,0.0008976628940956,Benign,0.0922,benign,-3.256,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P128V,NP_000537:p.Pro128Val,,,,,saturation_mutlist,,,,,,,,1.82296,0.14153611660003662,,-0.36464534524355646,,0.7291573273782217,,Neutral,Neutral,,Neutral,0.24026829940041727,,0.16291868244472585,2.11978,,0.007409994904719802,,1.06359499745236,,Uncertain,,Neutral,,0.17962409799565052,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.0828,1.774,-6.3249,-2.56557395349514,0.0083502899277511,Benign,0.1629,benign,-3.538,available,https://doi.org/10.1101/2022.10.22.513328 +P128W,NP_000537:p.Pro128Trp,,,,,saturation_mutlist,,,,,,,,1.18311,0.1375623106956482,,-1.3094998743884825,,-0.06319493719424119,,Neutral,Neutral,,Neutral,0.30668275596987254,,0.1644837683997695,1.70085,,-0.6810526645591742,,0.5098986677204129,,Neutral,,Neutral,,0.1991032890737849,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.2379,1.774,-22.1976,-4.48892609273751,0.8245128092316408,Pathogenic,0.5028,ambiguous,-4.296,available,https://doi.org/10.1101/2022.10.22.513328 +P128Y,NP_000537:p.Pro128Tyr,,,,,saturation_mutlist,,,,,,,,1.11262,0.12452542066574096,,-0.8113152107756232,,0.15065239461218838,,Neutral,Neutral,,Neutral,0.3255619720497352,,0.1833379123762752,1.5528,,-0.3315486219232123,,0.6106256890383939,,Neutral,,Neutral,,0.17213868558975073,64.293,7.172,59.685,5.444,,True,64.293,,neutral,neutral,neutral,,True,59.685,,neutral,neutral,neutral,uncertain,,-0.1585,1.774,-8.9098,-3.76176556916539,0.4164728236816874,Uncertain,0.3629,ambiguous,-3.93,available,https://doi.org/10.1101/2022.10.22.513328 +A129C,NP_000537:p.Ala129Cys,,,,,saturation_mutlist,,,,,,,,0.26615,-0.14619543075561522,,0.7280574282655828,,0.4971037141327914,,Neutral,Neutral,,Neutral,0.14277928946052082,,0.03565828443793301,0.29554,,0.9173055818050783,,0.6064227909025391,,Neutral,,Neutral,,0.17068658221740546,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.0209,2.6798,-7.9098,-0.203760346780239,5.482536215743321e-07,Benign,0.2084,benign,-3.067,available,https://doi.org/10.1101/2022.10.22.513328 +A129D,NP_000537:p.Ala129Asp,"hg19,17:g.7578544G>T, hg38,17:g.7675226G>T",,,0.553,"COSMIC,ClinVar,saturation_mutlist",1735669,Benign,1,,,,,0.49218,0.1741252076625824,0.23707666666666663,0.18351190508605064,0.36462833333333333,0.3378459525430253,Neutral,Neutral,Neutral,Neutral,Neutral,0.12629532794558926,0.2606935176707613,0.22798098974884262,0.83169,-0.34308333333333335,0.4751427399476486,0.24430333333333334,0.6534163699738244,Neutral,Neutral,Neutral,Neutral,0.28060826565793734,0.07024483203181343,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.0757,2.6798,-2.6245,0.297108760232245,1.9028916755345464e-19,Benign,0.0679,benign,-3.05,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A129E,NP_000537:p.Ala129Glu,,,,,saturation_mutlist,,,,,,,,0.0764,0.08968416929244993,,0.05574050067498335,,0.06607025033749167,,Neutral,Neutral,,Neutral,0.14551901365847222,,0.15216904240752901,0.51861,,0.7648078004595528,,0.6417089002297764,,Neutral,,Neutral,,0.0796932826376923,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.0547,2.6798,-1.3249,-0.243425604839551,6.691106461935032e-20,Benign,0.0903,benign,-3.0,available,https://doi.org/10.1101/2022.10.22.513328 +A129F,NP_000537:p.Ala129Phe,,,,,saturation_mutlist,,,,,,,,-0.60398,0.14310729742050168,,-0.41899807434981723,,-0.5114890371749086,,Neutral,Neutral,,Neutral,0.1824656865469654,,0.1508032505626676,0.02326,,-0.04919863433549867,,-0.012969317167749335,,Neutral,,Neutral,,0.22488189910007692,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.1439,2.6798,-22.1976,-3.6407435593294,2.995560249202388e-06,Benign,0.1479,benign,-3.204,available,https://doi.org/10.1101/2022.10.22.513328 +A129G,NP_000537:p.Ala129Gly,"hg19,17:g.7578544G>C, hg38,17:g.7675226G>C",,,0.407,"COSMIC,ClinVar,saturation_mutlist",458542,Uncertain significance,1,,,,,0.62183,0.3193455910682678,1.0259666666666667,0.6785985650895398,0.8238983333333334,0.6502142825447699,Neutral,Neutral,Neutral,Neutral,Neutral,0.05874514102108962,0.11651179520641776,0.19774816313096083,-1.57167,-0.9707500000000001,0.7543869243960414,-1.27121,-0.40864153780197926,Neutral,Neutral,Neutral,Neutral,0.12102565540688744,0.3195256624386268,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.0195,2.6798,-8.9098,-1.34299511046981,2.408457670310892e-12,Benign,0.0979,benign,-2.981,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A129H,NP_000537:p.Ala129His,,,,,saturation_mutlist,,,,,,,,-0.02165,-0.07396767377853393,,-0.32727217753112436,,-0.17446108876556218,,Neutral,Neutral,,Neutral,0.1404066642747898,,0.16581152392866919,0.58587,,0.0237175251460153,,0.30479376257300766,,Neutral,,Neutral,,0.09303479541081547,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.148,2.6798,-22.1976,-3.19244620671937,3.8001462794064563e-07,Benign,0.1559,benign,-3.062,available,https://doi.org/10.1101/2022.10.22.513328 +A129I,NP_000537:p.Ala129Ile,,,,,saturation_mutlist,,,,,,,,-0.36002,-0.1805327296257019,,-0.3534646494424529,,-0.35674232472122647,,Neutral,Neutral,,Neutral,0.27475901127741936,,0.11055022062474677,0.61126,,0.8586801337570287,,0.7349700668785144,,Neutral,,Neutral,,0.6551926030619223,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.0495,2.6798,-5.74,-0.133191786808946,5.0755307703633486e-14,Benign,0.0928,benign,-2.86,available,https://doi.org/10.1101/2022.10.22.513328 +A129K,NP_000537:p.Ala129Lys,,,,,saturation_mutlist,,,,,,,,-1.00043,-0.16561108350753784,,-0.2029047573701118,,-0.6016673786850558,,Neutral,Neutral,,Neutral,0.10316668927663436,,0.06366603747433375,0.00648,,0.4486724295856764,,0.22757621479283818,,Neutral,,Neutral,,0.29132711949962053,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.0862,2.6798,-6.5879,-1.79951774257786,9.225436927515566e-13,Benign,0.1659,benign,-2.929,available,https://doi.org/10.1101/2022.10.22.513328 +A129L,NP_000537:p.Ala129Leu,,,,,saturation_mutlist,,,,,,,,-0.66138,-0.07294988870620728,,-0.6350424753531048,,-0.6482112376765523,,Neutral,Neutral,,Neutral,0.15844331401082665,,0.13349560472863012,0.05092,,-0.1817387936561513,,-0.06540939682807566,,Neutral,,Neutral,,0.14818473268225582,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.0372,2.6798,-2.4021,-0.0845640339915606,4.2163103646140345e-14,Benign,0.079,benign,-2.721,available,https://doi.org/10.1101/2022.10.22.513328 +A129M,NP_000537:p.Ala129Met,,,,,saturation_mutlist,,,,,,,,-0.77871,0.04408565759658813,,-0.25594810609186475,,-0.5173290530459324,,Neutral,Neutral,,Neutral,0.13422690727265144,,0.13531205473135646,-0.16657,,0.09517240650543711,,-0.03569879674728144,,Neutral,,Neutral,,0.06542311826816369,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.0173,2.6798,-6.5879,-0.615773095568653,7.772171354114234e-11,Benign,0.1101,benign,-2.859,available,https://doi.org/10.1101/2022.10.22.513328 +A129N,NP_000537:p.Ala129Asn,,,,,saturation_mutlist,,,,,,,,0.02849,-0.08021657466888427,,0.026756719779958398,,0.0276233598899792,,Neutral,Neutral,,Neutral,0.1076159247357762,,0.14244342453068023,0.25204,,0.021514652733208673,,0.13677732636660433,,Neutral,,Neutral,,0.16336242309406956,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.1459,2.6798,-22.1976,-2.3158025736854,1.2823009340421845e-08,Benign,0.0842,benign,-3.001,available,https://doi.org/10.1101/2022.10.22.513328 +A129P,NP_000537:p.Ala129Pro,,,,,saturation_mutlist,,,,,,,,0.17305,1.0085816812515258,,3.463076083604951,,1.8180630418024755,,Uncertain,Uncertain,,Neutral,0.21202953551029238,,0.7296356893719504,1.18181,,4.9439873861037285,,3.0628986930518645,,Uncertain,,Destabilizing,,0.8742971126773604,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.1305,2.6798,-5.588,-0.731728531667761,7.805160211007782e-11,Benign,0.1234,benign,-2.88,available,https://doi.org/10.1101/2022.10.22.513328 +A129Q,NP_000537:p.Ala129Gln,,,,,saturation_mutlist,,,,,,,,-0.34865,-0.05481601238250731,,0.10168283529764677,,-0.12348358235117662,,Neutral,Neutral,,Neutral,0.11501077300707875,,0.09426875153573716,0.24343,,0.6898853440353349,,0.46665767201766745,,Neutral,,Neutral,,0.14269862679733747,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.0567,2.6798,-5.2094,-0.91649656371832,1.845597263117184e-13,Benign,0.1251,benign,-2.877,available,https://doi.org/10.1101/2022.10.22.513328 +A129R,NP_000537:p.Ala129Arg,,,,,saturation_mutlist,,,,,,,,-0.79998,-0.1894359731674194,,-0.4782581821408099,,-0.639119091070405,,Neutral,Neutral,,Neutral,0.1090811327167194,,0.12923039413341672,-0.04786,,0.0813672591719311,,0.016753629585965553,,Neutral,,Neutral,,0.32628525809842557,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.1765,2.6798,-22.1976,-2.80871485782904,1.2288468930040634e-06,Benign,0.1549,benign,-3.016,available,https://doi.org/10.1101/2022.10.22.513328 +A129S,NP_000537:p.Ala129Ser,"hg19,17:g.7578545C>A, hg19,17:g.7578545_7578546delinsAG, hg38,17:g.7675227C>A",,,0.475,"cBioPortal,ClinVar,saturation_mutlist",824314,Conflicting classifications of pathogenicity,1,,,,,0.44557,-0.049154515266418446,0.19240333333333334,0.21123902747946288,0.3189866666666667,0.32840451373973145,Neutral,Neutral,Neutral,Neutral,Neutral,0.06259364736103983,0.08369894238014931,0.14406293816910093,0.47784,-0.29626,0.6634424324628079,0.09078999999999998,0.570641216231404,Neutral,Neutral,Neutral,Neutral,0.1505779063032378,0.13339409830314966,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,0.0338,2.6798,-4.1025,-0.253874820879764,2.1126481285837232e-19,Benign,0.0672,benign,-2.798,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A129T,NP_000537:p.Ala129Thr,"hg19,17:g.7578545C>T, hg38,17:g.7675227C>T",,,0.438,"COSMIC,ClinVar,saturation_mutlist",482217,Conflicting classifications of pathogenicity,1,,,,,0.35975,-0.13132757663726805,-0.014399999999999994,0.09002641172475989,0.17267500000000002,0.22488820586237995,Neutral,Neutral,Neutral,Neutral,Neutral,0.16235217286670778,0.15596185965378417,0.12022429442404398,0.8408,-0.9275533333333333,0.9423113391739549,-0.043376666666666674,0.8915556695869775,Neutral,Neutral,Neutral,Neutral,0.2892152296973465,0.21422497831449028,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,0.025,2.6798,-4.662,-0.0060963391508014,2.5838406836788886e-17,Benign,0.063,benign,-2.806,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A129V,NP_000537:p.Ala129Val,"hg19,17:g.7578544G>A, hg38,17:g.7675226G>A",,,0.468,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",133280,not provided,0,,,,,0.11102,-0.15871293783187868,-0.16439666666666666,-0.23732942485961894,-0.026688333333333335,-0.06315471242980947,Neutral,Neutral,Neutral,Neutral,Neutral,0.24597950715284614,0.28780642456731614,0.0645122495668025,1.02458,1.4661,0.7195316443909988,1.2453400000000001,0.8720558221954995,Neutral,Neutral,Neutral,Neutral,0.4317014366434284,0.40538309324679594,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,0.024,2.6798,-5.4505,-0.0124595129485265,3.643567988753419e-15,Benign,0.0707,benign,-2.794,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A129W,NP_000537:p.Ala129Trp,,,,,saturation_mutlist,,,,,,,,-0.40484,0.2635775780677795,,-0.7393077343712138,,-0.5720738671856069,,Neutral,Neutral,,Neutral,0.15280722948775757,,0.1752221191898728,0.27394,,-0.06441715666633742,,0.1047614216668313,,Neutral,,Neutral,,0.09242856171736658,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.1548,2.6798,-22.1976,-3.6407435593294,5.581959426016299e-06,Benign,0.3789,ambiguous,-3.366,available,https://doi.org/10.1101/2022.10.22.513328 +A129Y,NP_000537:p.Ala129Tyr,,,,,saturation_mutlist,,,,,,,,-0.51767,0.13070682048797608,,-0.34968114896720653,,-0.4336755744836033,,Neutral,Neutral,,Neutral,0.1725488153771981,,0.14331499822200205,0.22229,,0.20245318256105702,,0.21237159128052852,,Neutral,,Neutral,,0.1573286888848705,68.824,8.27,68.135,18.157,,True,68.824,,neutral,neutral,neutral,,True,68.135,,neutral,neutral,neutral,uncertain,,-0.1631,2.6798,-22.1976,-3.6407435593294,1.2651315672586235e-06,Benign,0.1912,benign,-3.188,available,https://doi.org/10.1101/2022.10.22.513328 +L130A,NP_000537:p.Leu130Ala,,,,,saturation_mutlist,,,,,,,,1.84458,1.342749034166336,,2.1831885770278774,,2.013884288513939,,Uncertain,Uncertain,,Uncertain,0.4717187226281997,,0.3556957650678812,0.33116,,0.6672625153633716,,0.4992112576816858,,Neutral,,Neutral,,0.016716281795240068,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.4173,0.0216,-22.2006,-6.18310122350225,0.7978411619877073,Pathogenic,0.7907,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +L130C,NP_000537:p.Leu130Cys,,,,,saturation_mutlist,,,,,,,,1.71688,0.7566199541091919,,2.3787701605287057,,2.047825080264353,,Uncertain,Neutral,,Uncertain,0.3889612459176696,,0.3560167166045851,0.59762,,1.250929537450227,,0.9242747687251135,,Neutral,,Neutral,,0.001671787785489083,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.4065,0.0216,-22.2006,-5.46299709915179,0.6636860614300932,Uncertain,0.8165,pathogenic,-4.175,available,https://doi.org/10.1101/2022.10.22.513328 +L130D,NP_000537:p.Leu130Asp,"hg19,17:g.7578540_7578542delinsATC, hg38,17:g.7675222_7675224delinsATC",,,,"ClinVar,saturation_mutlist",2687693,Uncertain significance,0,,,,,2.87816,1.72504399061203,,2.584545640277067,,2.7313528201385333,,Uncertain,Uncertain,,Uncertain,0.42427123371028763,,0.5729745338342508,0.57152,,0.5902637803227634,,0.5808918901613818,,Neutral,,Neutral,,0.21635391412489607,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.5388,0.0216,-22.2006,-6.78499053412062,0.858974725700443,Pathogenic,0.9925,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328 +L130E,NP_000537:p.Leu130Glu,,,,,saturation_mutlist,,,,,,,,2.16827,1.6629427909851073,,2.1602697327407405,,2.16426986637037,,Uncertain,Uncertain,,Uncertain,0.45042918139854055,,0.4961550080642402,0.32419,,0.45146595496746983,,0.3878279774837349,,Neutral,,Neutral,,0.1302252041288875,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.5069,0.0216,-22.2006,-6.78499053412062,0.8706378212499449,Pathogenic,0.9407,pathogenic,-4.482,available,https://doi.org/10.1101/2022.10.22.513328 +L130F,NP_000537:p.Leu130Phe,"hg19,17:g.7578542G>A, hg19,17:g.7675224G>A, hg38,17:g.7675224G>A",,,0.921,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",216466,Conflicting classifications of pathogenicity,1,,,,,1.04931,1.1294909858703612,0.9051033333333333,1.0653357981105016,0.9772066666666666,1.0573228990552508,Neutral,Neutral,Uncertain,Neutral,Neutral,0.47881169285255815,0.36447419317269764,0.3681995001874761,0.16772,0.7654200000000001,0.32689682612305593,0.46657000000000004,0.24730841306152795,Neutral,Neutral,Neutral,Neutral,0.2201011005575998,0.06358090028954021,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.3508,0.0216,-22.2006,-7.40410911027577,0.8254853971127278,Pathogenic,0.8335,pathogenic,-4.117,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L130G,NP_000537:p.Leu130Gly,,,,,saturation_mutlist,,,,,,,,2.58683,1.7557615280151366,,3.2668256213528593,,2.9268278106764294,,Uncertain,Uncertain,,Uncertain,0.5481757106689423,,0.6336308408025784,0.68804,,1.2836939297179824,,0.9858669648589912,,Neutral,,Neutral,,0.17199415791315625,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.4922,0.0216,-22.2006,-7.49589491350442,0.8661542266059434,Pathogenic,0.9319,pathogenic,-4.401,available,https://doi.org/10.1101/2022.10.22.513328 +L130H,NP_000537:p.Leu130His,"hg19,17:g.7578541A>T, hg38,17:g.7675223A>T",,,0.924,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",824351,Pathogenic,1,,,,,1.52599,1.3828120589256288,0.94728,1.6459895396074373,1.236635,1.5859897698037186,Neutral,Neutral,Uncertain,Neutral,Neutral,0.5577872123401726,0.23030940941843142,0.4523670526241949,0.46391,0.7572533333333333,0.36029855164044805,0.6105816666666667,0.412104275820224,Neutral,Neutral,Neutral,Neutral,0.34093165535371184,0.09355799086430672,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.4597,0.0216,-22.2006,-6.63614231326096,0.8650003273198417,Pathogenic,0.916,pathogenic,-4.349,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L130I,NP_000537:p.Leu130Ile,"hg19,17:g.7578542G>T, hg38,17:g.7675224G>T",,,0.795,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.24594,0.651432273387909,0.85102,0.9939146628169305,1.04848,1.1199273314084652,Neutral,Neutral,Neutral,Neutral,Neutral,0.45690836558422754,0.04964123756179601,0.31358844259812585,0.14862,0.16916333333333333,0.28064953505600393,0.15889166666666665,0.21463476752800198,Neutral,Neutral,Neutral,Neutral,0.25486301174465387,0.1403925859578739,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.2236,0.0216,-8.9128,-2.74581486455328,0.7005477296183987,Pathogenic,0.4647,ambiguous,-3.907,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L130K,NP_000537:p.Leu130Lys,,,,,saturation_mutlist,,,,,,,,0.6765,1.2845701098442077,,2.0478855010587598,,1.3621927505293798,,Uncertain,Uncertain,,Neutral,0.5165971445392256,,0.5489785771024325,-0.06609,,0.5416595408413075,,0.23778477042065377,,Neutral,,Neutral,,0.08036098490162556,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.5059,0.0216,-22.2006,-5.42538959088761,0.4430372349150385,Uncertain,0.812,pathogenic,-4.132,available,https://doi.org/10.1101/2022.10.22.513328 +L130M,NP_000537:p.Leu130Met,,,,,saturation_mutlist,,,,,,,,0.25046,0.7144127202033996,,1.1403317898859946,,0.6953958949429973,,Neutral,Neutral,,Neutral,0.29763303938900015,,0.3295697064015939,-0.12743,,0.35136210601794743,,0.11196605300897372,,Neutral,,Neutral,,0.08792350344518816,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.3147,0.0216,-22.2006,-4.69858774823902,0.7902628822701911,Pathogenic,0.4372,ambiguous,-4.036,available,https://doi.org/10.1101/2022.10.22.513328 +L130N,NP_000537:p.Leu130Asn,,,,,saturation_mutlist,,,,,,,,1.62904,1.3538457322120667,,2.0215649243416127,,1.8253024621708063,,Uncertain,Uncertain,,Neutral,0.527131516048645,,0.31843509990891444,0.38427,,0.6427419902914687,,0.5135059951457344,,Neutral,,Neutral,,0.13654950395422671,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.4851,0.0216,-22.2006,-6.50026027365917,0.8332563880406113,Pathogenic,0.9351,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +L130P,NP_000537:p.Leu130Pro,"hg19,17:g.7578541A>G, hg19,17:g.7675223A>G, hg38,17:g.7675223A>G",,,0.927,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428873,Pathogenic,2,,,,,2.57737,1.9232782411575318,4.59059,5.3372858145700235,3.58398,3.957327907285012,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.39187110037758077,0.2679743125749184,0.9976279729265966,0.13513,4.1168933333333335,3.8631573115453257,2.126011666666667,1.999143655772663,Uncertain,Uncertain,Uncertain,Neutral,0.5479752645471835,1.3237027705112474,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.5007,0.0216,-22.2006,-7.93738882511137,0.8523211855016521,Pathogenic,0.9844,pathogenic,-4.45,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L130Q,NP_000537:p.Leu130Gln,,,,,saturation_mutlist,,,,,,,,1.59628,1.4150974655151367,,1.8545718923942303,,1.725425946197115,,Neutral,Uncertain,,Neutral,0.52288002820091,,0.2745869356824705,0.25109,,0.6911204221041957,,0.4711052110520978,,Neutral,,Neutral,,0.07721679506308993,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.4381,0.0216,-22.2006,-6.10847621764913,0.5024670005899488,Uncertain,0.767,pathogenic,-4.072,available,https://doi.org/10.1101/2022.10.22.513328 +L130R,NP_000537:p.Leu130Arg,"hg19,17:g.7578541A>C, hg19,17:g.7675223A>C, hg38,17:g.7675223A>C",,,0.918,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.55735,1.2698874354362488,1.0193866666666667,1.6046940192562467,0.7883683333333333,1.0810220096281233,Neutral,Neutral,Uncertain,Neutral,Neutral,0.5603117704932143,0.09025430195964189,0.4198874889394154,0.04631,0.6075966666666667,0.3545513071538773,0.3269533333333333,0.20043065357693865,Neutral,Neutral,Neutral,Neutral,0.27655669525232773,0.02324241554746258,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.4975,0.0216,-22.2006,-5.59660198154064,0.3647377200000811,Uncertain,0.6991,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L130S,NP_000537:p.Leu130Ser,,,,,saturation_mutlist,,,,,,,,2.13589,1.124215362071991,,2.65621436585385,,2.3960521829269252,,Uncertain,Uncertain,,Uncertain,0.668296608455882,,0.5777305974670397,0.54082,,0.8267812170471426,,0.6838006085235713,,Neutral,,Neutral,,0.14658868539131423,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.4477,0.0216,-22.2006,-6.36237635891577,0.8285755174767829,Pathogenic,0.926,pathogenic,-4.322,available,https://doi.org/10.1101/2022.10.22.513328 +L130T,NP_000537:p.Leu130Thr,,,,,saturation_mutlist,,,,,,,,2.38497,0.8137284469604492,,2.0785312427129874,,2.2317506213564937,,Uncertain,Neutral,,Uncertain,0.7980111018291857,,0.43151873794705103,0.41152,,0.6662711394008393,,0.5388955697004196,,Neutral,,Neutral,,0.13256872303654954,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.4204,0.0216,-22.2006,-5.24785576662641,0.4131419864471294,Uncertain,0.7858,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328 +L130V,NP_000537:p.Leu130Val,"hg19,17:g.7578542G>C, hg19,17:g.7675224G>C, hg38,17:g.7675224G>C",,,0.887,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458543,Conflicting classifications of pathogenicity,1,,,,,2.06235,0.8427822113037109,0.9091833333333333,1.3758239932652903,1.4857666666666667,1.7190869966326452,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.44356256253419213,0.07203292966106235,0.3535743200841605,0.42206,0.18027,0.35865439344443556,0.301165,0.3903571967222178,Neutral,Neutral,Neutral,Neutral,0.38897164840983806,0.07870244183540474,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.3277,0.0216,-22.2006,-3.61657390990045,0.6760825435897428,Uncertain,0.4003,ambiguous,-3.878,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L130W,NP_000537:p.Leu130Trp,,,,,saturation_mutlist,,,,,,,,1.71308,1.3471648931503295,,1.0239024997580783,,1.3684912498790391,,Neutral,Uncertain,,Neutral,0.49012380845661585,,0.4804552748582945,0.45607,,-0.013673582888470634,,0.22119820855576466,,Neutral,,Neutral,,0.0648980115346171,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.4499,0.0216,-22.2006,-7.40410911027577,0.8485637363004479,Pathogenic,0.9391,pathogenic,-4.43,available,https://doi.org/10.1101/2022.10.22.513328 +L130Y,NP_000537:p.Leu130Tyr,,,,,saturation_mutlist,,,,,,,,0.86913,1.2760406374931335,,1.3168951351481317,,1.0930125675740658,,Neutral,Uncertain,,Neutral,0.5489720757698339,,0.44851626046879967,0.06138,,0.43318946713460754,,0.24728473356730377,,Neutral,,Neutral,,0.0560868816828528,36.942,6.552,67.615,14.483,,False,36.942,,neutral,neutral,neutral,,False,67.615,,neutral,neutral,neutral,uncertain,,-0.4428,0.0216,-22.2006,-7.40410911027577,0.870327727664185,Pathogenic,0.952,pathogenic,-4.394,available,https://doi.org/10.1101/2022.10.22.513328 +N131A,NP_000537:p.Asn131Ala,,,,,saturation_mutlist,,,,,,,,1.01229,0.5648691296577454,,1.060052150378726,,1.036171075189363,,Neutral,Neutral,,Neutral,0.12359971206553708,,0.1053699157900661,0.12803,,0.26858034006107384,,0.19830517003053694,,Neutral,,Neutral,,0.04094371148843551,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2323,1.048,-22.2006,-4.72321591719334,0.7620915373248979,Pathogenic,0.5899,pathogenic,-4.074,available,https://doi.org/10.1101/2022.10.22.513328 +N131C,NP_000537:p.Asn131Cys,,,,,saturation_mutlist,,,,,,,,0.79637,0.06642664909362792,,1.4813007261305486,,1.1388353630652743,,Neutral,Neutral,,Neutral,0.06166798872522779,,0.10678499366313685,0.46707,,0.7650444018415797,,0.6160572009207899,,Neutral,,Neutral,,0.08550045345120279,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2822,1.048,-22.2006,-5.67942877960139,0.8109554889858922,Pathogenic,0.4411,ambiguous,-4.254,available,https://doi.org/10.1101/2022.10.22.513328 +N131D,NP_000537:p.Asn131Asp,"hg19,17:g.7578539T>C",,,0.724,"cBioPortal,saturation_mutlist",,,,,,,,0.04461,0.6543687343597412,0.6751666666666667,0.4340984019537508,0.35988833333333337,0.2393542009768754,Neutral,Neutral,Neutral,Neutral,Neutral,0.11653778085294389,0.38784762784142723,0.06343833643469739,-0.56385,1.0392266666666667,0.12211765513292842,0.2376883333333334,-0.22086617243353576,Neutral,Neutral,Neutral,Neutral,0.5405531020682016,0.14212397245083166,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2355,1.048,-22.2006,-3.41354932165107,0.1657176542163623,Benign,0.1983,benign,-3.696,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N131E,NP_000537:p.Asn131Glu,,,,,saturation_mutlist,,,,,,,,0.38855,0.7138112449645996,,0.7516280203367276,,0.5700890101683638,,Neutral,Neutral,,Neutral,0.09308118539781536,,0.0849920717592245,-0.27831,,0.17191035535345156,,-0.05319982232327422,,Neutral,,Neutral,,0.06841195293230957,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2626,1.048,-22.2006,-3.52185057982921,0.3168095866603812,Benign,0.5432,ambiguous,-3.927,available,https://doi.org/10.1101/2022.10.22.513328 +N131F,NP_000537:p.Asn131Phe,,,,,saturation_mutlist,,,,,,,,0.42189,0.5282771205902099,,0.7363598390358496,,0.5791249195179248,,Neutral,Neutral,,Neutral,0.0824854156548023,,0.0539187025070844,-0.22032,,-0.3263861730143474,,-0.2733530865071737,,Neutral,,Neutral,,0.3136150100159071,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2894,1.048,-22.2006,-6.0282901283126,0.8547560336858477,Pathogenic,0.9198,pathogenic,-4.405,available,https://doi.org/10.1101/2022.10.22.513328 +N131G,NP_000537:p.Asn131Gly,,,,,saturation_mutlist,,,,,,,,0.16823,-0.15276849269866943,,0.671576158510013,,0.4199030792550065,,Neutral,Neutral,,Neutral,0.21315828817626256,,0.10496172191248715,0.43196,,0.7935873461334887,,0.6127736730667444,,Neutral,,Neutral,,0.16323451182832951,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2631,1.048,-22.2006,-4.05784434724658,0.2933931687306382,Benign,0.2684,benign,-3.738,available,https://doi.org/10.1101/2022.10.22.513328 +N131H,NP_000537:p.Asn131His,"hg19,17:g.7578539T>G, hg38,17:g.7675221T>G",,,0.820,"COSMIC,ClinVar,saturation_mutlist",4279056,Likely pathogenic,1,,,,,0.65302,0.22499438047409057,0.8571466666666666,0.41249998781784764,0.7550833333333333,0.5327599939089238,Neutral,Neutral,Neutral,Neutral,Neutral,0.08450800254293574,0.4531001559871234,0.036009927061375166,0.37607,0.46712,-0.25902440181201913,0.421595,0.05852279909399044,Neutral,Neutral,Neutral,Neutral,0.5143960600548958,0.0729670198127967,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.1694,1.048,-8.9128,-4.08943111458614,0.1041294796306193,Benign,0.1721,benign,-3.635,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N131I,NP_000537:p.Asn131Ile,"hg19,17:g.7578538T>A, hg19,17:g.7675220T>A, hg38,17:g.7675220T>A",,,0.939,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428902,Pathogenic/Likely pathogenic,2,,,,,3.09878,1.3604892301559448,5.202496666666666,2.2134266433729475,4.150638333333333,2.656103321686474,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,0.11495425291718443,0.2091950688286467,0.3696137480085697,1.10253,1.0651933333333332,-0.04160679296889589,1.0838616666666665,0.530461603515552,Neutral,Neutral,Neutral,Neutral,0.4929795369203698,0.1907422198083983,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2147,1.048,-8.9128,-3.95781788600926,0.8344701937637363,Pathogenic,0.9111,pathogenic,-4.204,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N131K,NP_000537:p.Asn131Lys,"hg19,17:g.7578537G>C, hg19,17:g.7578537G>T, hg19,17:g.7675219G>T, hg38,17:g.7675219G>C, hg38,17:g.7675219G>T",3.18613394507e-05,1.1969740496e-05,"0.661, 0.662","cBioPortal,COSMIC,ClinVar,saturation_mutlist",246429,Uncertain significance,3,,,,,0.08464,0.26623852729797365,1.10669,0.5085600029767273,0.595665,0.2966000014883637,Neutral,Neutral,Neutral,Neutral,Neutral,0.10602191114716951,0.3451334994848611,0.06295599017303341,-0.2551,0.23922999999999997,0.11293555285511714,-0.007935000000000011,-0.07108222357244143,Neutral,Neutral,Neutral,Neutral,0.7190676014580734,0.022800054389225888,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.1261,1.048,-0.7631,-2.08630271146585,0.000455846416919,Benign,0.3836,ambiguous,-3.306,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N131L,NP_000537:p.Asn131Leu,,,,,saturation_mutlist,,,,,,,,0.99848,0.6586630034446717,,0.7112112925936206,,0.8548456462968104,,Neutral,Neutral,,Neutral,0.046323107250722015,,0.12700081989325712,-0.36011,,-0.4218395896842068,,-0.3909747948421034,,Neutral,,Neutral,,0.141441297924419,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.289,1.048,-22.2006,-5.99081550010343,0.8174109132435935,Pathogenic,0.7251,pathogenic,-4.24,available,https://doi.org/10.1101/2022.10.22.513328 +N131M,NP_000537:p.Asn131Met,,,,,saturation_mutlist,,,,,,,,0.94335,0.3725146770477295,,0.8228927630019788,,0.8831213815009894,,Neutral,Neutral,,Neutral,0.07429349788576974,,0.08681585661749723,-0.30735,,-0.11699306768359247,,-0.21217153384179624,,Neutral,,Neutral,,0.14114557209639103,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2431,1.048,-22.2006,-5.99081550010343,0.8679322680569956,Pathogenic,0.7767,pathogenic,-4.232,available,https://doi.org/10.1101/2022.10.22.513328 +N131P,NP_000537:p.Asn131Pro,,,,,saturation_mutlist,,,,,,,,5.80438,2.0767506837844847,,5.4603466027541065,,5.632363301377053,,Destabilizing,Destabilizing,,Destabilizing,0.13102008294787718,,0.5314193755441105,-0.8607,,0.6005308649896813,,-0.13008456750515934,,Neutral,,Neutral,,0.07400370824761407,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.3979,1.048,-22.2006,-6.80979896597955,0.8262655352400875,Pathogenic,0.9555,pathogenic,-4.241,available,https://doi.org/10.1101/2022.10.22.513328 +N131Q,NP_000537:p.Asn131Gln,,,,,saturation_mutlist,,,,,,,,0.34339,0.22661718130111694,,0.8752210418964571,,0.6093055209482285,,Neutral,Neutral,,Neutral,0.10432749130906746,,0.07684767571762392,0.08343,,0.25102111943641775,,0.16722555971820888,,Neutral,,Neutral,,0.023167941896284745,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2262,1.048,-22.2006,-3.50227611843883,0.3397015314576345,Uncertain,0.3629,ambiguous,-3.716,available,https://doi.org/10.1101/2022.10.22.513328 +N131R,NP_000537:p.Asn131Arg,,,,,saturation_mutlist,,,,,,,,0.33218,0.4660029482841492,,0.46451139878785436,,0.39834569939392717,,Neutral,Neutral,,Neutral,0.11342971501868099,,0.05863678314729107,0.10875,,-0.12440544294252374,,-0.007827721471261873,,Neutral,,Neutral,,0.08717359345114366,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2676,1.048,-22.2006,-3.13973064079933,0.0488833239309097,Benign,0.3838,ambiguous,-3.655,available,https://doi.org/10.1101/2022.10.22.513328 +N131S,NP_000537:p.Asn131Ser,"hg19,17:g.7578538T>C, hg19,17:g.7675220T>C, hg38,17:g.7675220T>C",,,0.859,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1057941,Uncertain significance,2,Uncertain significance,1,,,0.80261,0.5392556309700012,1.7730166666666667,0.958165666688037,1.2878133333333333,0.8803878333440185,Neutral,Neutral,Neutral,Neutral,Neutral,0.11232119767316714,0.25156185645328305,0.08777967594837831,0.63867,0.9395700000000001,0.27752750321638525,0.78912,0.4580987516081926,Neutral,Neutral,Neutral,Neutral,0.5218385438683757,0.14583546957995913,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2022,1.048,-22.2006,-5.06631023309027,0.6703594710432845,Uncertain,0.1566,benign,-3.734,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N131T,NP_000537:p.Asn131Thr,"hg19,17:g.7578538T>G, hg19,17:g.7675220T>G, hg38,17:g.7675220T>G",,,0.907,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.46415,1.1173537635803223,2.593313333333333,1.7094881656425607,2.5287316666666664,2.0868190828212803,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.12322732179035087,0.33804900644071645,0.1777793705248212,0.77423,1.0975033333333333,0.24078023927049327,0.9358666666666666,0.5075051196352466,Neutral,Neutral,Neutral,Neutral,0.8832289269996136,0.07886602419484762,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.1788,1.048,-7.9128,-3.83700919409569,0.4061077091461031,Uncertain,0.5533,ambiguous,-3.682,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N131V,NP_000537:p.Asn131Val,,,,,saturation_mutlist,,,,,,,,2.97909,1.31391441822052,,1.963034403429355,,2.4710622017146773,,Uncertain,Uncertain,,Uncertain,0.09783518088525824,,0.32968826596064577,0.78125,,0.1170804421964657,,0.44916522109823287,,Neutral,,Neutral,,0.1585381994092101,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2759,1.048,-22.2006,-5.99081550010343,0.8488199363520148,Pathogenic,0.8591,pathogenic,-4.327,available,https://doi.org/10.1101/2022.10.22.513328 +N131W,NP_000537:p.Asn131Trp,,,,,saturation_mutlist,,,,,,,,1.29084,0.7725603866577149,,0.5945078651409089,,0.9426739325704545,,Neutral,Neutral,,Neutral,0.10877505830191292,,0.1648559775657878,-0.06254,,-0.5607899073206696,,-0.3116649536603348,,Neutral,,Neutral,,0.3678143912750615,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.2945,1.048,-22.2006,-6.0282901283126,0.8675843250247417,Pathogenic,0.9305,pathogenic,-4.434,available,https://doi.org/10.1101/2022.10.22.513328 +N131Y,NP_000537:p.Asn131Tyr,"hg19,17:g.7578539T>A, hg38,17:g.7675221T>A",,,0.879,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141988,Pathogenic,1,Likely oncogenic,1,,,0.50558,0.6657083392143249,1.3320866666666666,0.776900478998404,0.9188333333333334,0.6412402394992021,Neutral,Neutral,Neutral,Neutral,Neutral,0.09260508859442859,0.2732144737909924,0.07231929705427571,-0.01416,0.20567,-0.2467553931925328,0.09575499999999999,-0.1304576965962664,Neutral,Neutral,Neutral,Neutral,1.2013096354395898,0.2874438422327993,66.971,4.019,53.24,12.195,,False,66.971,,neutral,neutral,neutral,,False,53.24,,neutral,neutral,neutral,uncertain,,-0.273,1.048,-22.2006,-6.0282901283126,0.8601617533056554,Pathogenic,0.5291,ambiguous,-4.3,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132A,NP_000537:p.Lys132Ala,,,,,saturation_mutlist,,,,,,,,1.26669,0.26652705430984497,,1.3018880705822153,,1.2842890352911076,,Neutral,Neutral,,Neutral,0.25827773322405834,,0.12794478060765746,0.61813,,0.5729726909665497,,0.5955513454832748,,Neutral,,Neutral,,0.09591801837634169,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.3173,0.0546,-22.2036,-7.8200062696862,0.8696162209505763,Pathogenic,0.9962,pathogenic,-4.349,available,https://doi.org/10.1101/2022.10.22.513328 +K132C,NP_000537:p.Lys132Cys,,,,,saturation_mutlist,,,,,,,,0.80481,0.0861411666870117,,1.6542659359521041,,1.229537967976052,,Neutral,Neutral,,Neutral,0.25443851842222936,,0.14167560161290496,0.33097,,0.8906381222140549,,0.6108040611070275,,Neutral,,Neutral,,0.2765959456656272,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.3875,0.0546,-22.2036,-7.8200062696862,0.8561700127366381,Pathogenic,0.9951,pathogenic,-4.4,available,https://doi.org/10.1101/2022.10.22.513328 +K132D,NP_000537:p.Lys132Asp,,,,,saturation_mutlist,,,,,,,,3.50628,1.7423287773132323,,2.7327017944381566,,3.1194908972190785,,Uncertain,Uncertain,,Destabilizing,0.2829452924971907,,0.21115044475730546,3.52892,,1.5328787767106944,,2.5308993883553472,,Uncertain,,Uncertain,,0.302877204627656,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.4263,0.0546,-22.2036,-7.55769165067509,0.8650643816746928,Pathogenic,0.9994,pathogenic,-4.566,available,https://doi.org/10.1101/2022.10.22.513328 +K132E,NP_000537:p.Lys132Glu,"hg19,17:g.7578536T>C, hg19,17:g.7675218T>C, hg38,17:g.7675218T>C",,3.988544899e-06,0.968,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376626,Conflicting classifications of pathogenicity,1,,,,,2.26837,0.8658285522460938,1.96338,1.991285496394859,2.115875,2.1298277481974295,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.2751866559141023,0.3732468317347114,0.09215979406048354,2.83844,1.0858266666666667,1.0602145803838854,1.9621333333333333,1.9493272901919427,Uncertain,Uncertain,Neutral,Neutral,0.5124805311640845,0.2912377284571191,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.3422,0.0546,-22.2036,-7.55769165067509,0.8705558087392056,Pathogenic,0.9978,pathogenic,-4.469,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132F,NP_000537:p.Lys132Phe,,,,,saturation_mutlist,,,,,,,,4.29885,0.6134144842624665,,-0.19070747520044432,,2.054071262399778,,Uncertain,Neutral,,Uncertain,0.2830042539965311,,0.15623187001660085,0.37902,,-0.7855261896587801,,-0.20325309482939002,,Neutral,,Neutral,,0.7196311112918313,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,uncertain,,-0.3884,0.0546,-22.2036,-7.8200062696862,0.8657937953296413,Pathogenic,0.9995,pathogenic,-4.628,available,https://doi.org/10.1101/2022.10.22.513328 +K132G,NP_000537:p.Lys132Gly,,,,,saturation_mutlist,,,,,,,,2.43568,1.3851103258132935,,2.9923686039919843,,2.714024301995992,,Uncertain,Uncertain,,Uncertain,0.2134019187312428,,0.14306136722188229,1.47815,,1.9900397102291283,,1.7340948551145643,,Neutral,,Neutral,,0.12455725539986187,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.3765,0.0546,-22.2036,-7.8200062696862,0.8701981039720101,Pathogenic,0.9969,pathogenic,-4.455,available,https://doi.org/10.1101/2022.10.22.513328 +K132H,NP_000537:p.Lys132His,,,,,saturation_mutlist,,,,,,,,3.51489,0.75926589012146,,0.8301535397086676,,2.1725217698543338,,Uncertain,Neutral,,Uncertain,0.18253432905107012,,0.07507419433235266,1.43485,,-0.004896907727213943,,0.714976546136393,,Neutral,,Neutral,,0.4533295741963525,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.3274,0.0546,-22.2036,-7.8200062696862,0.8696605699344608,Pathogenic,0.9837,pathogenic,-4.38,available,https://doi.org/10.1101/2022.10.22.513328 +K132I,NP_000537:p.Lys132Ile,"hg19,17:g.7578534_7578535delinsAA",,,,"cBioPortal,saturation_mutlist",,,,,,,,0.12481,-0.3732177710533142,-0.8226733333333334,0.16301083993710272,-0.3489316666666667,0.14391041996855136,Neutral,Neutral,Neutral,Neutral,Neutral,0.46085322019601055,0.7299267096694633,0.2411627445640214,0.62702,-1.66383,-0.4630952791168323,-0.518405,0.08196236044158386,Neutral,Neutral,Neutral,Neutral,0.41505055459144574,0.39345078226107155,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,uncertain,,-0.3556,0.0546,-22.2036,-6.84932683484845,0.8703343017234512,Pathogenic,0.997,pathogenic,-4.503,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132L,NP_000537:p.Lys132Leu,,,,,saturation_mutlist,,,,,,,,-0.99059,0.18320061206817628,,-0.19781594317621867,,-0.5942029715881093,,Neutral,Neutral,,Neutral,0.42361986409430996,,0.2230062865482454,-0.4962,,-0.7886949542451952,,-0.6424474771225976,,Neutral,,Neutral,,0.4851344619769365,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,uncertain,,-0.3543,0.0546,-22.2036,-6.84932683484845,0.8679826758186007,Pathogenic,0.9933,pathogenic,-4.296,available,https://doi.org/10.1101/2022.10.22.513328 +K132M,NP_000537:p.Lys132Met,"hg19,17:g.7578535T>A, hg19,17:g.7675217T>A, hg38,17:g.7675217T>A",,,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376629,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,-1.11502,0.03145997762680052,-0.4289133333333333,0.35217174493818915,-0.7719666666666666,-0.3814241275309054,Neutral,Neutral,Neutral,Neutral,Neutral,0.23189860420059472,0.15108857586050495,0.22240688588183744,-0.74018,-0.57789,-0.26250117926907307,-0.659035,-0.5013405896345365,Neutral,Neutral,Neutral,Neutral,0.5296745221989317,0.4816791518710167,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.2515,0.0546,-7.3309,-3.94411653735206,0.144850327736009,Benign,0.9874,pathogenic,-3.86,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132N,NP_000537:p.Lys132Asn,"hg19,17:g.7578534C>A, hg19,17:g.7578534C>G, hg19,17:g.7675216C>A, hg19,17:g.7675216C>G, hg38,17:g.7675216C>A, hg38,17:g.7675216C>G",,,,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","634773, 376624","Pathogenic/Likely pathogenic, Likely pathogenic","2, 3","Oncogenic, Likely oncogenic","1, 1",Tier I - Strong,1,1.32215,1.22203471660614,2.0173466666666666,1.5246814620372684,1.6697483333333332,1.4234157310186342,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.16907682985342773,0.04272988831667539,0.08449342034547513,0.94995,1.0407033333333333,0.6970723345569826,0.9953266666666667,0.8235111672784913,Neutral,Neutral,Neutral,Neutral,0.1181737608589807,0.20265376133048418,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.3355,0.0546,-22.2036,-7.55769165067509,0.8708643304763221,Pathogenic,0.9987,pathogenic,-4.171,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132P,NP_000537:p.Lys132Pro,,,,,saturation_mutlist,,,,,,,,7.35428,1.6061945152282715,,6.634431738509231,,6.9943558692546155,,Destabilizing,Uncertain,,Destabilizing,0.27454559638081744,,0.9531482810643073,7.85898,,4.686363153212643,,6.272671576606321,,Destabilizing,,Destabilizing,,0.6570858952046676,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.4916,0.0546,-22.2036,-7.8200062696862,0.8708435253115391,Pathogenic,0.9989,pathogenic,-4.525,available,https://doi.org/10.1101/2022.10.22.513328 +K132Q,NP_000537:p.Lys132Gln,"hg19,17:g.7578536T>G, hg19,17:g.7675218T>G, hg38,17:g.7675218T>G",,,0.944,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376628,Conflicting classifications of pathogenicity,1,,,,,0.61728,0.12442059516906738,0.69286,1.2631472539278645,0.65507,0.9402136269639323,Neutral,Neutral,Neutral,Neutral,Neutral,0.14220780265394,0.09991912563001475,0.2040596040063906,0.64447,0.27834333333333333,0.5161726868746207,0.46140666666666663,0.5803213434373103,Neutral,Neutral,Neutral,Neutral,0.1984387990176204,0.26273669187366044,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.3165,0.0546,-22.2036,-7.55769165067509,0.3046919840954846,Benign,0.9807,pathogenic,-3.852,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132R,NP_000537:p.Lys132Arg,"hg19,17:g.7578535T>C, hg19,17:g.7675217T>C, hg38,17:g.7675217T>C",,0.0,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376625,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,-0.03293,0.050353488922119126,0.05215333333333335,0.6655338066487565,0.009611666666666675,0.31630190332437824,Neutral,Neutral,Neutral,Neutral,Neutral,0.0892385669912716,0.16763715386380063,0.08749991248196691,-0.08235,-0.26474,-0.07293554667199297,-0.173545,-0.07764277333599648,Neutral,Neutral,Neutral,Neutral,0.49443752547718295,0.21464698930665846,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,uncertain,,-0.2509,0.0546,-22.2036,-4.12552491681601,0.1713027627812074,Benign,0.5077,ambiguous,-3.498,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132S,NP_000537:p.Lys132Ser,,,,,saturation_mutlist,,,,,,,,1.36946,0.5799126601219178,,2.1561278410352442,,1.762793920517622,,Uncertain,Neutral,,Neutral,0.1864014201414095,,0.07044306268738859,0.70467,,1.112110540561204,,0.9083902702806019,,Neutral,,Neutral,,0.22375366292579119,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.3274,0.0546,-22.2036,-7.8200062696862,0.8628055962212964,Pathogenic,0.9982,pathogenic,-4.299,available,https://doi.org/10.1101/2022.10.22.513328 +K132T,NP_000537:p.Lys132Thr,"hg19,17:g.7578535T>G, hg19,17:g.7675217T>G, hg38,17:g.7675217T>G",,,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376627,Conflicting classifications of pathogenicity,1,,,,,1.06562,0.19993897914886474,0.3705233333333333,1.4131641701933748,0.7180716666666667,1.2393920850966875,Neutral,Neutral,Neutral,Neutral,Neutral,0.3005705012714837,0.04827761823269891,0.13084041288766216,0.77992,-0.23174666666666668,0.49794203402604137,0.27408666666666665,0.6389310170130207,Neutral,Neutral,Neutral,Neutral,0.4073914390634912,0.29756819658830247,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.3393,0.0546,-22.2036,-7.8200062696862,0.8707351252137716,Pathogenic,0.9872,pathogenic,-4.13,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132V,NP_000537:p.Lys132Val,,,,,saturation_mutlist,,,,,,,,0.2352,-0.36251738786697385,,0.39708724117043426,,0.3161436205852171,,Neutral,Neutral,,Neutral,0.40901343740940066,,0.27767425945853264,0.50566,,-0.3182865640095064,,0.0936867179952468,,Neutral,,Neutral,,0.4068313318997762,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,neutral,,-0.3395,0.0546,-22.2036,-4.6401008462263,0.863384336316444,Pathogenic,0.9928,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328 +K132W,NP_000537:p.Lys132Trp,"hg38,17:g.7675217_7675218delinsCA",,,,"COSMIC,saturation_mutlist",,,,,,,,4.17212,0.6710497117042542,0.98027,-0.05435955757946829,2.576195,2.0588802212102655,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.26615055490110234,0.8379102065257351,0.17478336881913578,1.66782,-0.16780000000000003,-0.9322759115372022,0.7500100000000001,0.3677720442313989,Neutral,Neutral,Neutral,Neutral,0.3978814293228574,0.7318868557666126,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,uncertain,,-0.3974,0.0546,-22.2036,-7.8200062696862,0.8686634137297546,Pathogenic,0.9994,pathogenic,-4.561,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132Y,NP_000537:p.Lys132Tyr,,,,,saturation_mutlist,,,,,,,,4.68418,0.7603786587715149,,0.18776955004451049,,2.435974775022255,,Uncertain,Neutral,,Uncertain,0.2915116818649891,,0.13831335442793335,0.79886,,-0.4876277696176658,,0.1556161151911671,,Neutral,,Neutral,,0.6648906111756187,10.041,4.067,12.68,6.789,,False,10.041,,neutral,neutral,neutral,,False,12.68,,neutral,neutral,neutral,uncertain,,-0.3733,0.0546,-22.2036,-7.8200062696862,0.8604811615588429,Pathogenic,0.9976,pathogenic,-4.567,available,https://doi.org/10.1101/2022.10.22.513328 +M133A,NP_000537:p.Met133Ala,,,,,saturation_mutlist,,,,,,,,3.18533,1.676955771446228,,2.229311375944599,,2.7073206879722997,,Uncertain,Uncertain,,Uncertain,0.27357061078433786,,0.30077054606188297,2.19457,,1.9247013138437346,,2.0596356569218672,,Uncertain,,Uncertain,,0.06177741424270905,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,neutral,,-0.3734,0.306,-22.2066,-6.76749764248868,5.9338488819333425e-09,Benign,0.8922,pathogenic,-3.085,available,https://doi.org/10.1101/2022.10.22.513328 +M133C,NP_000537:p.Met133Cys,,,,,saturation_mutlist,,,,,,,,2.72268,0.8325568413734437,,2.3774502891034834,,2.5500651445517417,,Uncertain,Neutral,,Uncertain,0.2100308633663637,,0.32104224292599576,1.76874,,2.1829623552055177,,1.9758511776027587,,Uncertain,,Neutral,,0.14312170916656342,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,neutral,,-0.3789,0.306,-22.2066,-6.95369664079319,4.197190326739781e-05,Benign,0.8983,pathogenic,-3.449,available,https://doi.org/10.1101/2022.10.22.513328 +M133D,NP_000537:p.Met133Asp,,,,,saturation_mutlist,,,,,,,,4.07116,2.49758722782135,,3.4010404654387507,,3.7361002327193753,,Destabilizing,Destabilizing,,Destabilizing,0.3677817651979902,,0.20681370916126987,2.9929,,2.7190495434866526,,2.8559747717433264,,Uncertain,,Uncertain,,0.28985079599796193,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,neutral,,-0.4848,0.306,-22.2066,-7.34409950369429,0.0001930909298142,Benign,0.9987,pathogenic,-3.706,available,https://doi.org/10.1101/2022.10.22.513328 +M133E,NP_000537:p.Met133Glu,,,,,saturation_mutlist,,,,,,,,3.3598,2.514008431434631,,2.654056001330727,,3.006928000665363,,Uncertain,Destabilizing,,Destabilizing,0.34261875168007194,,0.40538999978897045,2.66495,,2.3149448617299937,,2.489947430864997,,Uncertain,,Uncertain,,0.20000130223056686,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,neutral,,-0.475,0.306,-22.2066,-7.34409950369429,5.66832045679349e-05,Benign,0.9916,pathogenic,-3.597,available,https://doi.org/10.1101/2022.10.22.513328 +M133F,NP_000537:p.Met133Phe,,,,,saturation_mutlist,,,,,,,,2.97176,0.7008682370185852,,-0.14956835927059,,1.411095820364705,,Uncertain,Neutral,,Neutral,0.21621860000140275,,0.30790493643879213,6.18604,,0.13764671944112541,,3.161843359720563,,Uncertain,,Destabilizing,,0.4533468002322359,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,uncertain,,-0.3784,0.306,-22.2066,-7.34409950369429,6.135065389835606e-06,Benign,0.7425,pathogenic,-3.05,available,https://doi.org/10.1101/2022.10.22.513328 +M133G,NP_000537:p.Met133Gly,,,,,saturation_mutlist,,,,,,,,5.0863,2.7561008167266845,,4.088556870307269,,4.587428435153635,,Destabilizing,Destabilizing,,Destabilizing,0.3320395119560544,,0.3355264019073914,3.47981,,3.3125694777724863,,3.3961897388862434,,Destabilizing,,Destabilizing,,0.2204011713007643,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,neutral,,-0.4543,0.306,-22.2066,-7.34409950369429,1.7790310131268225e-05,Benign,0.9764,pathogenic,-3.614,available,https://doi.org/10.1101/2022.10.22.513328 +M133H,NP_000537:p.Met133His,,,,,saturation_mutlist,,,,,,,,3.36474,2.4136817550659178,,1.2990286273706333,,2.3318843136853165,,Uncertain,Destabilizing,,Uncertain,0.34555349237793676,,0.37980081702211177,5.03088,,1.225902319028634,,3.128391159514317,,Uncertain,,Destabilizing,,0.261269144310148,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,neutral,,-0.4317,0.306,-22.2066,-7.34409950369429,5.238552256164728e-06,Benign,0.9849,pathogenic,-3.41,available,https://doi.org/10.1101/2022.10.22.513328 +M133I,NP_000537:p.Met133Ile,"hg19,17:g.7578531C>A, hg19,17:g.7578531C>T, hg38,17:g.7675213C>A, hg38,17:g.7675213C>G, hg38,17:g.7675213C>T",,7.9728286001e-06,"0.477, 0.479","cBioPortal,COSMIC,ClinVar,saturation_mutlist",421437,Conflicting classifications of pathogenicity,1,,,,,2.11971,-0.4535989189147949,1.5667799999999998,0.21498312210214113,1.843245,1.1673465610510705,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.46191040152396307,0.2719331838276945,0.3725170387022145,0.58849,0.48390333333333335,0.4989158086633634,0.5361966666666667,0.5437029043316817,Neutral,Neutral,Neutral,Neutral,0.6397045991358477,0.5882931397499837,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,uncertain,,-0.2907,0.306,-22.2066,-3.928979085432,1.6468697728704282e-11,Benign,0.5785,pathogenic,-2.818,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M133K,NP_000537:p.Met133Lys,"hg19,17:g.7578532A>T, hg19,17:g.7675214A>T, hg38,17:g.7675214A>T",,,0.845,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2430159,Uncertain significance,1,Likely oncogenic,1,,,3.50805,2.758882608413696,4.1081666666666665,3.156884748443184,3.808108333333333,3.332467374221592,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.32373814581681654,0.3992754326137395,0.707523601824603,3.66539,3.3286866666666666,1.9693244328947952,3.4970383333333332,2.8173572164473977,Destabilizing,Uncertain,Destabilizing,Uncertain,0.18282048979501417,0.47731472340799336,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,uncertain,,-0.4359,0.306,-22.2066,-7.34409950369429,4.2256231316959206e-06,Benign,0.9651,pathogenic,-3.424,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M133L,NP_000537:p.Met133Leu,"hg19,17:g.7578533T>A, hg38,17:g.7675215T>A, hg38,17:g.7675215T>G",,,0.426,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.244,-0.6487087726593017,0.20521666666666669,-0.21673986837698278,0.22460833333333335,0.013630065811508607,Neutral,Neutral,Neutral,Neutral,Neutral,0.3081767633538874,0.5001354152849228,0.34273407562010166,0.25145,0.07415000000000001,-0.1262886579070129,0.1628,0.06258067104649355,Neutral,Neutral,Neutral,Neutral,0.5436542031475522,0.3709863910365377,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,uncertain,,-0.1447,0.306,-0.0765,-0.324119412855083,6.554492214307761e-33,Benign,0.0735,benign,-2.846,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M133N,NP_000537:p.Met133Asn,,,,,saturation_mutlist,,,,,,,,3.4883,2.536014423370361,,2.2104532702144057,,2.8493766351072027,,Uncertain,Destabilizing,,Uncertain,0.298030447434748,,0.3008402882552925,2.61445,,1.7636901224045516,,2.1890700612022758,,Uncertain,,Uncertain,,0.15321097402840972,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,neutral,,-0.4265,0.306,-22.2066,-7.34409950369429,4.40367552830072e-06,Benign,0.9848,pathogenic,-3.478,available,https://doi.org/10.1101/2022.10.22.513328 +M133P,NP_000537:p.Met133Pro,,,,,saturation_mutlist,,,,,,,,4.82846,2.4089971780776978,,6.554778949173541,,5.691619474586771,,Destabilizing,Destabilizing,,Destabilizing,0.29800357298159363,,0.6752361495590543,3.91403,,6.378438041445482,,5.146234020722741,,Destabilizing,,Destabilizing,,1.0654569679297898,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,neutral,,-0.5443,0.306,-22.2066,-7.34409950369429,8.462734934672547e-06,Benign,0.9952,pathogenic,-3.456,available,https://doi.org/10.1101/2022.10.22.513328 +M133Q,NP_000537:p.Met133Gln,,,,,saturation_mutlist,,,,,,,,3.12133,2.2830683469772337,,1.7289992401918628,,2.4251646200959316,,Uncertain,Destabilizing,,Uncertain,0.2746143831134666,,0.3661905654657385,2.57598,,1.6661052371323422,,2.121042618566171,,Uncertain,,Uncertain,,0.19741263153378721,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,neutral,,-0.4185,0.306,-22.2066,-7.34409950369429,4.280071402143997e-05,Benign,0.9499,pathogenic,-3.442,available,https://doi.org/10.1101/2022.10.22.513328 +M133R,NP_000537:p.Met133Arg,"hg19,17:g.7578532A>C, hg19,17:g.7675214A>C, hg38,17:g.7675214A>C",,,0.849,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2687699,Uncertain significance,0,,,,,4.12969,2.7494506072998046,3.9620166666666665,1.9968989104882817,4.0458533333333335,3.063294455244141,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.33856311623318575,0.4171169912892809,0.6656476153641909,4.92389,2.9984133333333336,1.230351901022144,3.961151666666667,3.077120950511072,Uncertain,Uncertain,Destabilizing,Destabilizing,0.605775312379837,0.32342327914405505,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,uncertain,,-0.4632,0.306,-22.2066,-7.34409950369429,8.413985349902001e-05,Benign,0.969,pathogenic,-3.322,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M133S,NP_000537:p.Met133Ser,,,,,saturation_mutlist,,,,,,,,4.61523,2.3975773429870606,,3.193321401508958,,3.9042757007544795,,Destabilizing,Destabilizing,,Destabilizing,0.2643841468281835,,0.35646898867660654,2.80569,,2.6299353518757873,,2.7178126759378936,,Uncertain,,Uncertain,,0.2725955097539878,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,neutral,,-0.4048,0.306,-22.2066,-6.95369664079319,3.706710179197653e-05,Benign,0.9731,pathogenic,-3.43,available,https://doi.org/10.1101/2022.10.22.513328 +M133T,NP_000537:p.Met133Thr,"hg19,17:g.7578532A>G, hg38,17:g.7675214A>G",,,0.780,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12357,Pathogenic,2,,,,,3.41363,2.20407274723053,2.6999999999999997,1.9039590224919205,3.056815,2.65879451124596,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,0.2791466602276944,0.3015984238464562,0.42052514689528664,2.29609,2.6268700000000003,1.9637428595696882,2.46148,2.129916429784844,Uncertain,Uncertain,Uncertain,Uncertain,0.16147388416294037,0.2689364822986259,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,neutral,,-0.3445,0.306,-22.2066,-6.95369664079319,7.756525062442728e-06,Benign,0.9114,pathogenic,-3.284,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M133V,NP_000537:p.Met133Val,"hg19,17:g.7578533T>C, hg38,17:g.7675215T>C",,3.9868275219e-06,0.503,"COSMIC,ClinVar,saturation_mutlist",528246,Uncertain significance,1,,,,,1.51133,0.12271076679229737,1.11485,0.5488394058344884,1.3130899999999999,1.0300847029172442,Neutral,Neutral,Neutral,Neutral,Neutral,0.4323560153807618,0.5276403280644875,0.3577311815301593,0.86057,0.8232433333333334,0.8634743894587863,0.8419066666666667,0.8620221947293931,Neutral,Neutral,Neutral,Neutral,0.7933350183175383,0.5050026685912838,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,neutral,,-0.2549,0.306,-8.9187,-3.96856910757131,1.7018556235446606e-13,Benign,0.2123,benign,-2.795,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M133W,NP_000537:p.Met133Trp,,,,,saturation_mutlist,,,,,,,,6.3036,1.388632414340973,,0.49405503791827066,,3.3988275189591355,,Uncertain,Uncertain,,Destabilizing,0.4597811839439515,,0.4402744824735949,8.09982,,0.4411439465301868,,4.270481973265093,,Uncertain,,Destabilizing,,0.4484378684131142,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,uncertain,,-0.4412,0.306,-22.2066,-7.34409950369429,8.286633640167262e-06,Benign,0.9727,pathogenic,-3.516,available,https://doi.org/10.1101/2022.10.22.513328 +M133Y,NP_000537:p.Met133Tyr,,,,,saturation_mutlist,,,,,,,,4.37109,1.6777693796157838,,0.5662434036316529,,2.468666701815826,,Uncertain,Uncertain,,Uncertain,0.3959517499284589,,0.3685499698642687,7.57397,,0.5842262203197991,,4.0790981101599,,Uncertain,,Destabilizing,,0.41661977351546303,1.237,1.277,1.33,0.78,,False,1.237,,neutral,neutral,neutral,,False,1.33,,neutral,neutral,neutral,uncertain,,-0.4207,0.306,-22.2066,-7.34409950369429,5.656324993536331e-06,Benign,0.9556,pathogenic,-3.386,available,https://doi.org/10.1101/2022.10.22.513328 +F134A,NP_000537:p.Phe134Ala,,,,,saturation_mutlist,,,,,,,,4.51035,2.549001703262329,,4.662271733278964,,4.586310866639482,,Destabilizing,Destabilizing,,Destabilizing,0.23821920571288374,,0.22584257447226874,2.84322,,3.7290274051555876,,3.286123702577794,,Uncertain,,Destabilizing,,0.31964270340613454,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.369,0.8705,-22.2066,-7.13917580462256,0.868115606021729,Pathogenic,0.9995,pathogenic,-4.424,available,https://doi.org/10.1101/2022.10.22.513328 +F134C,NP_000537:p.Phe134Cys,"hg19,17:g.7578529A>C, hg19,17:g.7675211A>C, hg38,17:g.7675211A>C",,3.9849845781e-06,0.949,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",230477,Likely pathogenic,2,,,,,3.70326,1.69495671749115,3.94626,4.7298848286719055,3.8247600000000004,4.216572414335953,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.16668425414847599,0.14764401173092004,0.2501545571486198,2.6887,2.9781200000000005,3.8339893263989304,2.83341,3.2613446631994654,Uncertain,Uncertain,Uncertain,Destabilizing,0.7371971915754065,0.3008295839532134,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.3372,0.8705,-22.2066,-7.13917580462256,0.8568063888549966,Pathogenic,0.9992,pathogenic,-4.18,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F134D,NP_000537:p.Phe134Asp,,,,,saturation_mutlist,,,,,,,,5.07952,2.5386393642425538,,5.6784181615390095,,5.3789690807695045,,Destabilizing,Destabilizing,,Destabilizing,0.18795763959716003,,0.14112152515829252,4.41902,,4.445991942747793,,4.432505971373896,,Destabilizing,,Destabilizing,,0.5144984451863223,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.492,0.8705,-22.2066,-7.13917580462256,0.869659588137159,Pathogenic,0.9995,pathogenic,-4.617,available,https://doi.org/10.1101/2022.10.22.513328 +F134E,NP_000537:p.Phe134Glu,,,,,saturation_mutlist,,,,,,,,5.09644,2.4781456279754637,,5.334976621998588,,5.215708310999294,,Destabilizing,Destabilizing,,Destabilizing,0.11214719370071774,,0.16110634959196685,3.99012,,4.25075030829442,,4.12043515414721,,Destabilizing,,Destabilizing,,0.3046415432830082,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.4614,0.8705,-22.2066,-7.13917580462256,0.8704013923774918,Pathogenic,0.9998,pathogenic,-4.665,available,https://doi.org/10.1101/2022.10.22.513328 +F134G,NP_000537:p.Phe134Gly,,,,,saturation_mutlist,,,,,,,,6.1225,2.6891982460021975,,6.825397937641948,,6.473948968820974,,Destabilizing,Destabilizing,,Destabilizing,0.1505532756484332,,0.2683555141671319,3.84295,,5.392904868184524,,4.6179274340922625,,Destabilizing,,Destabilizing,,0.517611492966657,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.4044,0.8705,-22.2066,-7.13917580462256,0.8629705170552813,Pathogenic,0.9994,pathogenic,-4.536,available,https://doi.org/10.1101/2022.10.22.513328 +F134H,NP_000537:p.Phe134His,,,,,saturation_mutlist,,,,,,,,3.04915,1.8097758865356446,,2.814166083375262,,2.931658041687631,,Uncertain,Uncertain,,Uncertain,0.12551199469323593,,0.14241257079637482,2.29371,,2.0578768160312837,,2.175793408015642,,Uncertain,,Uncertain,,0.22196083120328652,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.3966,0.8705,-22.2066,-4.28611797678312,0.8674635262703196,Pathogenic,0.9971,pathogenic,-4.123,available,https://doi.org/10.1101/2022.10.22.513328 +F134I,NP_000537:p.Phe134Ile,"hg19,17:g.7578530A>T, hg38,17:g.7675212A>T",,,0.955,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480953,Pathogenic/Likely pathogenic,2,,,,,1.84005,1.7663555812835694,1.8939899999999998,2.750117229830971,1.86702,2.2950836149154856,Neutral,Uncertain,Uncertain,Neutral,Uncertain,0.30113900482790107,0.600265183398138,0.36043910738717466,1.06701,1.7431999999999999,1.8029887548435202,1.4051049999999998,1.43499937742176,Neutral,Neutral,Neutral,Neutral,0.9006856544137174,0.46659226254882125,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.313,0.8705,-22.2066,-6.89973504256994,0.8705290292679408,Pathogenic,0.9978,pathogenic,-4.28,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F134K,NP_000537:p.Phe134Lys,,,,,saturation_mutlist,,,,,,,,3.55327,2.5082279872894286,,5.694386388723796,,4.623828194361898,,Destabilizing,Destabilizing,,Destabilizing,0.1372754658106474,,0.12638177268664508,2.89523,,4.048534232448408,,3.4718821162242044,,Uncertain,,Destabilizing,,0.47077745383403874,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.4682,0.8705,-22.2066,-7.13917580462256,0.8627164969176122,Pathogenic,0.9998,pathogenic,-4.527,available,https://doi.org/10.1101/2022.10.22.513328 +F134L,NP_000537:p.Phe134Leu,"hg19,17:g.7578528A>C, hg19,17:g.7578528A>T, hg19,17:g.7578530A>G, hg19,17:g.7675210A>T, hg19,17:g.7675212A>G, hg38,17:g.7675210A>C, hg38,17:g.7675210A>T, hg38,17:g.7675212A>G",,,"0.872, 0.942","cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","1018290, 871293, 80710","Uncertain significance, Conflicting classifications of pathogenicity, Uncertain significance","1, 1, 1",Likely oncogenic,1,Tier I - Strong,1,1.55104,1.837033019065857,2.81213,2.2579016474781475,2.181585,1.9044708237390737,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.18609384269154725,1.3957122321118585,0.3060196157067532,0.81456,1.70204,1.3329257233741105,1.2583,1.0737428616870552,Neutral,Neutral,Neutral,Neutral,1.1477877428340137,0.4083890887844057,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.2751,0.8705,-22.2066,-6.01506292260617,0.8618877313062725,Pathogenic,0.9996,pathogenic,-3.916,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F134M,NP_000537:p.Phe134Met,,,,,saturation_mutlist,,,,,,,,1.199,1.867640380859375,,2.595257204795653,,1.8971286023978267,,Uncertain,Uncertain,,Neutral,0.16772686917428967,,0.2968589232658244,0.88524,,1.8722275875938934,,1.3787337937969468,,Neutral,,Neutral,,0.3573065956210895,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.3061,0.8705,-22.2066,-6.89973504256994,0.8641042152085098,Pathogenic,0.9989,pathogenic,-4.184,available,https://doi.org/10.1101/2022.10.22.513328 +F134N,NP_000537:p.Phe134Asn,,,,,saturation_mutlist,,,,,,,,4.0087,2.446413059234619,,4.294123249140505,,4.151411624570253,,Destabilizing,Destabilizing,,Destabilizing,0.1342667123146385,,0.13900882366627024,2.89253,,3.2987707623757223,,3.095650381187861,,Uncertain,,Destabilizing,,0.3506867880717803,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.4217,0.8705,-22.2066,-7.13917580462256,0.8379188085896098,Pathogenic,0.9984,pathogenic,-4.242,available,https://doi.org/10.1101/2022.10.22.513328 +F134P,NP_000537:p.Phe134Pro,,,,,saturation_mutlist,,,,,,,,6.38089,2.3387340545654296,,8.07353773914673,,7.227213869573365,,Destabilizing,Destabilizing,,Destabilizing,0.16511272342981925,,0.49408587309102703,3.76331,,6.68841750018074,,5.22586375009037,,Destabilizing,,Destabilizing,,0.2506384903701451,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.4924,0.8705,-22.2066,-7.13917580462256,0.8595313422714179,Pathogenic,0.9999,pathogenic,-4.601,available,https://doi.org/10.1101/2022.10.22.513328 +F134Q,NP_000537:p.Phe134Gln,,,,,saturation_mutlist,,,,,,,,4.26103,2.505697431564331,,4.413495009746505,,4.3372625048732525,,Destabilizing,Destabilizing,,Destabilizing,0.1274144857765839,,0.1370876494617831,2.90486,,3.347026022980707,,3.125943011490354,,Uncertain,,Destabilizing,,0.38748327070340416,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.4237,0.8705,-22.2066,-7.13917580462256,0.8699252067211151,Pathogenic,0.9998,pathogenic,-4.395,available,https://doi.org/10.1101/2022.10.22.513328 +F134R,NP_000537:p.Phe134Arg,,,,,saturation_mutlist,,,,,,,,5.00295,2.2934249210357667,,4.585698702186781,,4.79432435109339,,Destabilizing,Destabilizing,,Destabilizing,0.1375262486390555,,0.1624828252319137,3.34892,,3.130065906674026,,3.239492953337013,,Destabilizing,,Destabilizing,,0.6669150738711225,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.4696,0.8705,-22.2066,-7.13917580462256,0.8673618541935252,Pathogenic,0.9991,pathogenic,-4.368,available,https://doi.org/10.1101/2022.10.22.513328 +F134S,NP_000537:p.Phe134Ser,"hg19,17:g.7578529A>G, hg19,17:g.7675211A>G, hg38,17:g.7675211A>G",,,0.942,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1519634,Uncertain significance,1,,,,,5.17705,2.4533987045288086,5.10476,5.600850957409166,5.140905,5.388950478704583,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.23723526804599274,0.2664055890304606,0.17594636070883773,3.63165,3.35941,4.334287978191088,3.49553,3.9829689890955438,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.8648006975020315,0.43077848940071123,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.348,0.8705,-22.2066,-7.13917580462256,0.8626046487774373,Pathogenic,0.9992,pathogenic,-4.314,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F134T,NP_000537:p.Phe134Thr,,,,,saturation_mutlist,,,,,,,,4.43734,2.259243383407593,,4.608885216107279,,4.523112608053639,,Destabilizing,Destabilizing,,Destabilizing,0.25507049574193147,,0.1781369642627459,2.68409,,3.4789823383121043,,3.081536169156052,,Uncertain,,Destabilizing,,0.3663899623606234,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.3943,0.8705,-22.2066,-7.13917580462256,0.8674723279839714,Pathogenic,0.9997,pathogenic,-4.344,available,https://doi.org/10.1101/2022.10.22.513328 +F134V,NP_000537:p.Phe134Val,"hg19,17:g.7578530A>C, hg19,17:g.7675212A>C, hg38,17:g.7675212A>C",,,0.959,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",988615,Conflicting classifications of pathogenicity,1,,,,,2.57389,1.9195566844940186,2.09354,3.1496349755111908,2.3337149999999998,2.8617624877555956,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.3495909977235998,0.5499512580220178,0.2146011951717549,1.41817,1.7626966666666668,2.197896846204562,1.5904333333333334,1.808033423102281,Neutral,Uncertain,Neutral,Neutral,0.402618704759506,0.3850326814872949,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.3073,0.8705,-22.2066,-6.89973504256994,0.8650574421560595,Pathogenic,0.9977,pathogenic,-4.276,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F134W,NP_000537:p.Phe134Trp,,,,,saturation_mutlist,,,,,,,,2.88936,0.47603004932403564,,1.3491167868625027,,2.1192383934312513,,Uncertain,Neutral,,Uncertain,0.2457043612319447,,0.19221509316272614,1.3367,,0.46270896996862776,,0.8997044849843139,,Neutral,,Neutral,,0.1330126845211941,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,neutral,,-0.2926,0.8705,-22.2066,-4.28611797678312,0.8662794954303654,Pathogenic,0.964,pathogenic,-4.284,available,https://doi.org/10.1101/2022.10.22.513328 +F134Y,NP_000537:p.Phe134Tyr,"hg19,17:g.7578529A>T, hg38,17:g.7675211A>T",,,0.637,"ClinVar,saturation_mutlist",1509393,Uncertain significance,1,,,,,1.14653,0.06239380359649657,0.5815199999999999,1.0983239942667051,0.864025,1.1224269971333527,Neutral,Neutral,Neutral,Neutral,Neutral,0.20558112319136432,0.2410057231685588,0.10080133896399134,0.3023,0.19966000000000003,0.4996469422699276,0.25098000000000004,0.40097347113496384,Neutral,Neutral,Neutral,Neutral,0.5671039730654924,0.07743576117071775,0.073,0.353,2.775,2.611,,False,0.073,,neutral,neutral,neutral,,False,2.775,,neutral,neutral,neutral,uncertain,,-0.1501,0.8705,-0.4968,-1.865470728872,6.06060541571613e-06,Benign,0.4046,ambiguous,-2.968,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135A,NP_000537:p.Cys135Ala,,,,,saturation_mutlist,,,,,,,,0.58827,0.4762088131904602,,0.7562978483912346,,0.6722839241956173,,Neutral,Neutral,,Neutral,0.22900151161995627,,0.17766315587973672,0.46689,,0.15923855542596246,,0.31306427771298123,,Neutral,,Neutral,,0.09700855615427184,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.4923,0.0001,-22.2066,-3.63717197669355,0.4580950570525748,Uncertain,0.9583,pathogenic,-4.07,available,https://doi.org/10.1101/2022.10.22.513328 +C135D,NP_000537:p.Cys135Asp,,,,,saturation_mutlist,,,,,,,,2.86734,2.225779914855957,,2.7783479405773797,,2.82284397028869,,Uncertain,Destabilizing,,Uncertain,0.4448588635690028,,0.5025579076266811,3.32453,,1.5800764681206942,,2.4523032340603472,,Uncertain,,Uncertain,,0.4548780723505974,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.5996,0.0001,-22.2066,-7.76909942258231,0.8336369045825085,Pathogenic,0.9998,pathogenic,-4.824,available,https://doi.org/10.1101/2022.10.22.513328 +C135E,NP_000537:p.Cys135Glu,,,,,saturation_mutlist,,,,,,,,2.79501,2.048060779571533,,2.6058430047531824,,2.700426502376591,,Uncertain,Destabilizing,,Uncertain,0.23684753215061416,,0.7491446332792324,5.29696,,1.6315726154978905,,3.4642663077489453,,Uncertain,,Destabilizing,,0.2633822305306529,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.5872,0.0001,-22.2066,-7.76909942258231,0.8523294015886864,Pathogenic,0.9999,pathogenic,-4.882,available,https://doi.org/10.1101/2022.10.22.513328 +C135F,NP_000537:p.Cys135Phe,"hg19,17:g.7578525_7578526delinsAA, hg19,17:g.7578526C>A, hg19,17:g.7675208C>A, hg38,17:g.7675208C>A",,,0.960,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376559,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,5.36352,0.5653632712364197,2.9837866666666666,0.3189361926979605,4.173653333333333,2.8412280963489804,Uncertain,Uncertain,Neutral,Destabilizing,Uncertain,0.40882623285921904,1.806490437844115,1.4251215411049258,12.61752,2.72086,0.38570562311504414,7.66919,6.501612811557522,Uncertain,Uncertain,Destabilizing,Destabilizing,0.7848206246440436,0.4686394312586475,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.4863,0.0001,-22.2066,-7.76909942258231,0.8197195351106296,Pathogenic,0.986,pathogenic,-4.44,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135G,NP_000537:p.Cys135Gly,"hg19,17:g.7578527A>C, hg19,17:g.7675209A>C, hg38,17:g.7675209A>C",,,0.965,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376563,Pathogenic,3,,,,,2.24981,1.78505859375,2.7903633333333335,3.423201562951686,2.520086666666667,2.836505781475843,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.2118913873316044,0.05711544118907102,0.24285740760883168,0.28793,2.3752833333333334,2.0416951138284696,1.3316066666666666,1.1648125569142347,Uncertain,Uncertain,Neutral,Neutral,0.5856571922398138,0.16305603627708082,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.4848,0.0001,-22.2066,-7.19112192806731,0.8412958068476148,Pathogenic,0.9352,pathogenic,-4.515,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135H,NP_000537:p.Cys135His,,,,,saturation_mutlist,,,,,,,,4.70096,1.5158307003974913,,1.348194501846149,,3.0245772509230746,,Uncertain,Uncertain,,Destabilizing,0.44286441893071654,,1.0483365673869094,9.94796,,0.9689256010571815,,5.458442800528591,,Uncertain,,Destabilizing,,0.32040160903728343,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.5981,0.0001,-22.2066,-7.76909942258231,0.8467471373750963,Pathogenic,0.999,pathogenic,-4.676,available,https://doi.org/10.1101/2022.10.22.513328 +C135I,NP_000537:p.Cys135Ile,,,,,saturation_mutlist,,,,,,,,-0.84967,0.14463576555252072,,-0.894237218531518,,-0.871953609265759,,Neutral,Neutral,,Neutral,0.21838404737702571,,0.2917525430217221,2.87645,,-0.07314096216987681,,1.4016545189150618,,Uncertain,,Neutral,,0.3483252904554396,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.5162,0.0001,-22.2066,-4.77824995041311,0.4426942348457688,Uncertain,0.9614,pathogenic,-4.046,available,https://doi.org/10.1101/2022.10.22.513328 +C135K,NP_000537:p.Cys135Lys,,,,,saturation_mutlist,,,,,,,,3.09506,1.8834446334838868,,3.7456726071047277,,3.420366303552364,,Destabilizing,Uncertain,,Destabilizing,0.39593219992210626,,1.1750430499782978,7.17009,,3.4061591224891576,,5.288124561244579,,Destabilizing,,Destabilizing,,0.9530318353318669,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.5878,0.0001,-22.2066,-7.76909942258231,0.8643058448763606,Pathogenic,0.9999,pathogenic,-4.762,available,https://doi.org/10.1101/2022.10.22.513328 +C135L,NP_000537:p.Cys135Leu,,,,,saturation_mutlist,,,,,,,,-1.032,0.6420527648925781,,-0.5737850037295033,,-0.8028925018647517,,Neutral,Neutral,,Neutral,0.2479270128660523,,0.6526235606833032,2.86685,,-0.30918326968315957,,1.27883336515842,,Uncertain,,Neutral,,0.2686720899994081,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.5493,0.0001,-22.2066,-5.24580571604154,0.8485371855670276,Pathogenic,0.9613,pathogenic,-4.178,available,https://doi.org/10.1101/2022.10.22.513328 +C135M,NP_000537:p.Cys135Met,,,,,saturation_mutlist,,,,,,,,-1.14829,0.5365236854553223,,0.3747097121925134,,-0.38679014390374333,,Neutral,Neutral,,Neutral,0.27162672051346787,,0.8165058756717496,2.6405,,0.10905644977809048,,1.3747782248890452,,Uncertain,,Neutral,,0.32881017973890264,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.5165,0.0001,-22.2066,-5.14118386430122,0.8258066705361237,Pathogenic,0.9913,pathogenic,-4.282,available,https://doi.org/10.1101/2022.10.22.513328 +C135N,NP_000537:p.Cys135Asn,,,,,saturation_mutlist,,,,,,,,1.77052,1.9731160926818847,,1.3359888953162402,,1.5532544476581203,,Neutral,Uncertain,,Neutral,0.40784753793691275,,0.319324456120106,2.14598,,0.6582536069932857,,1.402116803496643,,Uncertain,,Neutral,,0.11091500335658729,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.542,0.0001,-22.2066,-7.76909942258231,0.8479744749952804,Pathogenic,0.9981,pathogenic,-4.6,available,https://doi.org/10.1101/2022.10.22.513328 +C135P,NP_000537:p.Cys135Pro,,,,,saturation_mutlist,,,,,,,,3.93272,1.6717699003219604,,5.195714115802546,,4.564217057901273,,Destabilizing,Uncertain,,Destabilizing,0.45857107465438157,,0.5514253270463304,3.67993,,4.814930014286232,,4.247430007143116,,Destabilizing,,Destabilizing,,0.43740518385253735,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.6107,0.0001,-22.2066,-7.76909942258231,0.8608869238756596,Pathogenic,0.9992,pathogenic,-4.755,available,https://doi.org/10.1101/2022.10.22.513328 +C135Q,NP_000537:p.Cys135Gln,,,,,saturation_mutlist,,,,,,,,1.85994,1.5441218543052673,,1.579908184053112,,1.719924092026556,,Neutral,Uncertain,,Neutral,0.4664857855365766,,0.7963623311733963,5.7888,,1.1829884973305884,,3.485894248665294,,Uncertain,,Destabilizing,,0.33966008040036605,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.566,0.0001,-22.2066,-7.76909942258231,0.8569851786578213,Pathogenic,0.9992,pathogenic,-4.697,available,https://doi.org/10.1101/2022.10.22.513328 +C135R,NP_000537:p.Cys135Arg,"hg19,17:g.7578527A>G, hg19,17:g.7675209A>G, hg38,17:g.7675209A>G",,,0.964,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376560,Pathogenic/Likely pathogenic,2,,,,,7.33965,1.954982614517212,6.327323333333333,2.5967381687759743,6.8334866666666665,4.968194084387987,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.4068239855563656,1.915453110055744,1.2527423355042226,12.69396,5.334583333333334,2.437971640789274,9.014271666666668,7.565965820394638,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.8353548358365774,1.0200114020212998,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.5446,0.0001,-22.2066,-7.76909942258231,0.8382912015293101,Pathogenic,0.9978,pathogenic,-4.565,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135S,NP_000537:p.Cys135Ser,"hg19,17:g.7578526C>G, hg19,17:g.7578527A>T, hg19,17:g.7675208C>G, hg38,17:g.7675208C>G, hg38,17:g.7675209A>T",,,"0.954, 0.957","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","3893309, 376562","Likely pathogenic, Conflicting classifications of pathogenicity","1, 1",,,,,1.45467,0.9583040118217468,1.59569,1.9933297466807398,1.52518,1.7239998733403699,Neutral,Neutral,Neutral,Neutral,Neutral,0.23754184328621253,0.27613884152722884,0.3069331843915501,0.83561,1.3675733333333333,1.1457604221825266,1.1015916666666667,0.9906852110912633,Neutral,Neutral,Neutral,Neutral,0.25697769764882106,0.09158625819047064,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.4831,0.0001,-22.2066,-4.68415718676229,0.8702095371151793,Pathogenic,0.958,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135T,NP_000537:p.Cys135Thr,"hg38,17:g.7675208_7675210delinsGTG",,,,"COSMIC,saturation_mutlist",,,,,,,,0.2205,0.9479034352302551,0.59002,0.6860274936315506,0.40526,0.4532637468157753,Neutral,Neutral,Neutral,Neutral,Neutral,0.20977608864450892,0.25098085504675455,0.06378386156720459,0.50325,0.6156466666666667,0.45374866980007705,0.5594483333333333,0.4784993349000385,Neutral,Neutral,Neutral,Neutral,0.5388599949481828,0.07367851456917189,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.5178,0.0001,-22.2066,-4.03339101020224,0.6039329838060254,Uncertain,0.9364,pathogenic,-3.964,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135V,NP_000537:p.Cys135Val,,,,,saturation_mutlist,,,,,,,,-1.12888,-0.06125712394714355,,-0.9642757908251233,,-1.0465778954125617,,Neutral,Neutral,,Neutral,0.20561632507371164,,0.11024006795462238,1.66067,,-0.38517474686311876,,0.6377476265684406,,Neutral,,Neutral,,0.18835086493037287,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.5143,0.0001,-22.2066,-2.75741532825132,0.5160001157723466,Uncertain,0.8707,pathogenic,-3.803,available,https://doi.org/10.1101/2022.10.22.513328 +C135W,NP_000537:p.Cys135Trp,"hg19,17:g.7578525G>C, hg19,17:g.7675207G>C, hg38,17:g.7675207G>C",,,0.884,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376561,Conflicting classifications of pathogenicity,1,,,,,15.79798,0.6846480822563171,7.820070000000001,1.6924837781764746,11.809025000000002,8.745231889088238,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,0.6462015213452261,3.114443997066999,1.7719564961569576,26.85575,7.610206666666667,1.381502338164163,17.232978333333335,14.118626169082082,Destabilizing,Uncertain,Destabilizing,Destabilizing,1.0046672355340132,0.7719065378804094,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.4894,0.0001,-22.2066,-7.76909942258231,0.8438731335427598,Pathogenic,0.9986,pathogenic,-4.58,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135Y,NP_000537:p.Cys135Tyr,"hg19,17:g.7578526C>T, hg19,17:g.7675208C>T, hg38,17:g.7675208C>T",,0.0,0.955,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141762,Conflicting classifications of pathogenicity,1,,,,,9.19674,0.8792647075653076,3.957596666666667,1.3362248657130735,6.577168333333334,5.266482432856537,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,0.5089938539202871,2.0154758920303553,1.614394133706064,17.08422,4.40703,1.1581764445800846,10.745624999999999,9.121198222290042,Destabilizing,Uncertain,Destabilizing,Destabilizing,1.1864476462392544,0.7017761047711344,0.357,0.512,0.235,0.348,,False,0.357,,neutral,neutral,neutral,,False,0.235,,neutral,neutral,neutral,uncertain,,-0.4956,0.0001,-22.2066,-7.76909942258231,0.8558744238904845,Pathogenic,0.998,pathogenic,-4.432,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136A,NP_000537:p.Gln136Ala,,,,,saturation_mutlist,,,,,,,,0.20313,0.35721688985824585,,0.36301351852688785,,0.2830717592634439,,Neutral,Neutral,,Neutral,0.2201878019706063,,0.05567240082598184,-0.18365,,0.1506013933878445,,-0.01652430330607775,,Neutral,,Neutral,,0.16754449364648638,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.2921,0.0831,-22.2066,-6.07479924986444,0.8189513046682451,Pathogenic,0.7569,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328 +Q136C,NP_000537:p.Gln136Cys,,,,,saturation_mutlist,,,,,,,,0.34496,0.512207853794098,,0.9888461260153975,,0.6669030630076987,,Neutral,Neutral,,Neutral,0.2188007011960783,,0.03887117706845213,0.08425,,0.8256951695218192,,0.4549725847609096,,Neutral,,Neutral,,0.10183535549588106,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.3383,0.0831,-22.2066,-6.11443374786994,0.8468264934742922,Pathogenic,0.9825,pathogenic,-4.468,available,https://doi.org/10.1101/2022.10.22.513328 +Q136D,NP_000537:p.Gln136Asp,,,,,saturation_mutlist,,,,,,,,1.45333,2.001424136161804,,1.1925994589828868,,1.3229647294914435,,Neutral,Destabilizing,,Neutral,0.3317783985293935,,0.005993097257327265,-0.52722,,0.5254094609852541,,-0.0009052695073729633,,Neutral,,Neutral,,0.21734452261627818,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.3786,0.0831,-22.2066,-3.53119377224444,0.5621465368322383,Uncertain,0.9794,pathogenic,-4.234,available,https://doi.org/10.1101/2022.10.22.513328 +Q136E,NP_000537:p.Gln136Glu,"hg19,17:g.7578524G>C, hg19,17:g.7675206G>C, hg38,17:g.7675206G>C",,,0.862,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480751,Conflicting classifications of pathogenicity,1,,,,,1.07288,0.6220569849014282,1.01916,0.5361405872393861,1.04602,0.8045102936196931,Neutral,Neutral,Neutral,Neutral,Neutral,0.22074537826905521,0.14781581534689267,0.03747530673878489,-0.12217,0.74399,0.25271732686228304,0.31091,0.06527366343114152,Neutral,Neutral,Neutral,Neutral,0.40670870222638056,0.12971777389211794,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.2972,0.0831,-22.2066,-3.96356314997428,0.6556975998327883,Uncertain,0.7507,pathogenic,-4.201,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136F,NP_000537:p.Gln136Phe,,,,,saturation_mutlist,,,,,,,,0.82266,1.1229809784889222,,-0.4016742435972948,,0.21049287820135257,,Neutral,Uncertain,,Neutral,0.20264487015588395,,0.02877320184587925,-0.41592,,-0.4136449144671979,,-0.41478245723359897,,Neutral,,Neutral,,0.12546895092489427,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.3463,0.0831,-22.2066,-6.79269182513879,0.8700496026826428,Pathogenic,0.9884,pathogenic,-4.582,available,https://doi.org/10.1101/2022.10.22.513328 +Q136G,NP_000537:p.Gln136Gly,,,,,saturation_mutlist,,,,,,,,1.44191,1.2560812425613403,,1.7302713025195031,,1.5860906512597515,,Neutral,Uncertain,,Neutral,0.21926826505096794,,0.03591819303701196,-0.47744,,1.216041433051832,,0.36930071652591606,,Neutral,,Neutral,,0.20223077964024058,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.3627,0.0831,-22.2066,-6.03279846291544,0.7237408510483924,Pathogenic,0.8554,pathogenic,-4.364,available,https://doi.org/10.1101/2022.10.22.513328 +Q136H,NP_000537:p.Gln136His,"hg19,17:g.7578522T>A, hg19,17:g.7578522T>G, hg19,17:g.7675204T>A, hg38,17:g.7675204T>A, hg38,17:g.7675204T>G",,,0.946,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","482213, 186301","Uncertain significance, Uncertain significance","2, 2",,,,,1.17458,1.0054469537734985,0.8324266666666666,0.19482991038012207,1.0035033333333332,0.684704955190061,Neutral,Neutral,Uncertain,Neutral,Neutral,0.15395213360243565,0.4561408453049952,0.13832244246073763,0.38941,0.3202933333333334,-0.17108186345344756,0.3548516666666667,0.10916406827327621,Neutral,Neutral,Neutral,Neutral,1.049098374838551,0.04670001190156865,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.2931,0.0831,-22.2066,-5.9678328038887,0.8278741802972036,Pathogenic,0.9347,pathogenic,-4.061,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136I,NP_000537:p.Gln136Ile,,,,,saturation_mutlist,,,,,,,,0.84337,1.0080539560317994,,-0.22122073042026102,,0.31107463478986946,,Neutral,Uncertain,,Neutral,0.3626153833522791,,0.07976507427812256,0.78303,,-0.3376727284273864,,0.2226786357863068,,Neutral,,Neutral,,0.08981942460968717,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.3277,0.0831,-22.2066,-5.98894516201986,0.7336346054825247,Pathogenic,0.9617,pathogenic,-4.469,available,https://doi.org/10.1101/2022.10.22.513328 +Q136K,NP_000537:p.Gln136Lys,"hg38,17:g.7675206G>T",,,0.869,"COSMIC,saturation_mutlist",,,,,,,,-0.57592,0.4292312788963318,0.5851500000000001,0.40359895021364905,0.004615000000000036,-0.08616052489317547,Neutral,Neutral,Neutral,Neutral,Neutral,0.21465906114868002,0.09292118201285789,0.05162113672604867,-0.15931,0.8524933333333333,0.1343625533346217,0.34659166666666663,-0.01247372333268916,Neutral,Neutral,Neutral,Neutral,0.12470765823405645,0.14762572268121793,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.3252,0.0831,-22.2066,-4.52687386162523,0.1155611862640654,Benign,0.7678,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136L,NP_000537:p.Gln136Leu,"hg19,17:g.7578523T>A, hg38,17:g.7675205T>A",,,0.959,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3906024,Uncertain significance,1,,,,,-0.91744,0.9262775993347168,0.5879833333333333,-0.39306190649450157,-0.16472833333333337,-0.6552509532472508,Neutral,Neutral,Neutral,Neutral,Neutral,0.3379299050968138,0.107757251985913,0.1236698119898896,-0.59006,-0.3795933333333334,-0.6798693565762628,-0.48482666666666674,-0.6349646782881314,Neutral,Neutral,Neutral,Neutral,0.5220462997559593,0.13206056754233378,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.311,0.0831,-22.2066,-4.75013824650229,0.6105873545019772,Uncertain,0.7798,pathogenic,-4.147,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136M,NP_000537:p.Gln136Met,,,,,saturation_mutlist,,,,,,,,-0.80672,0.46124911308288574,,-0.0654802273342061,,-0.43610011366710305,,Neutral,Neutral,,Neutral,0.1579663116018728,,0.06810668190592939,-0.46793,,-0.24374504895327476,,-0.3558375244766374,,Neutral,,Neutral,,0.10055169323134638,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.282,0.0831,-22.2066,-5.98654735740999,0.6586092103503343,Uncertain,0.8546,pathogenic,-4.242,available,https://doi.org/10.1101/2022.10.22.513328 +Q136N,NP_000537:p.Gln136Asn,,,,,saturation_mutlist,,,,,,,,0.91767,1.429151837825775,,0.7855866993152348,,0.8516283496576174,,Neutral,Uncertain,,Neutral,0.24441817670447763,,0.05050034317813038,-0.14717,,0.2452152646819931,,0.04902263234099655,,Neutral,,Neutral,,0.11789431070854763,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.3077,0.0831,-22.2066,-3.5328148857172,0.0786184914553901,Benign,0.8454,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328 +Q136P,NP_000537:p.Gln136Pro,"hg19,17:g.7578523T>G, hg19,17:g.7675205T>G, hg38,17:g.7675205T>G",,,0.964,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",580807,Conflicting classifications of pathogenicity,1,,,,,5.32474,2.642383575439453,6.522786666666666,5.641625034729782,5.9237633333333335,5.483182517364892,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.2462483141026073,1.2863022966196123,0.6468736964484482,-1.46634,4.571996666666666,4.6781385735695435,1.5528283333333333,1.605899286784772,Uncertain,Uncertain,Neutral,Neutral,0.8309697225263717,2.452828001033602,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.4657,0.0831,-22.2066,-7.55484873899529,0.8667725459074227,Pathogenic,0.9437,pathogenic,-4.435,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136R,NP_000537:p.Gln136Arg,"hg38,17:g.7675205T>C",,,0.877,"COSMIC,saturation_mutlist",,,,,,,,-0.37896,0.639829912185669,0.39830000000000004,0.009188595924975666,0.009670000000000012,-0.18488570203751217,Neutral,Neutral,Neutral,Neutral,Neutral,0.22260810922871635,0.0994399239071846,0.053348730825335054,0.07558,0.6043066666666667,-0.1843188231563432,0.3399433333333333,-0.05436941157817161,Neutral,Neutral,Neutral,Neutral,0.22793338446913727,0.2207141237301503,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.2441,0.0831,-6.5969,-3.00005215368022,0.0048621775462786,Benign,0.6506,pathogenic,-3.742,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136S,NP_000537:p.Gln136Ser,,,,,saturation_mutlist,,,,,,,,0.9187,0.6599576306343079,,1.0353259698825361,,0.9770129849412681,,Neutral,Neutral,,Neutral,0.2712016340473491,,0.05816641351657942,-0.06027,,0.6833991808218737,,0.3115645904109368,,Neutral,,Neutral,,0.09705033065667804,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.3105,0.0831,-22.2066,-5.91381299408609,0.6830269456205689,Pathogenic,0.707,pathogenic,-4.175,available,https://doi.org/10.1101/2022.10.22.513328 +Q136T,NP_000537:p.Gln136Thr,,,,,saturation_mutlist,,,,,,,,0.85682,0.8901642942428589,,0.5269158706182959,,0.6918679353091479,,Neutral,Neutral,,Neutral,0.3156822041358978,,0.06673896808248986,0.98119,,0.3834770049038421,,0.682333502451921,,Neutral,,Neutral,,0.0804827373303392,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.3204,0.0831,-22.2066,-6.13762588658129,0.7240386421979033,Pathogenic,0.8488,pathogenic,-4.241,available,https://doi.org/10.1101/2022.10.22.513328 +Q136V,NP_000537:p.Gln136Val,,,,,saturation_mutlist,,,,,,,,0.83187,0.8697249722480774,,-0.030101035817146463,,0.40088448209142674,,Neutral,Neutral,,Neutral,0.31263123151789457,,0.07172025232121965,0.59626,,-0.03651595582082443,,0.2798720220895878,,Neutral,,Neutral,,0.10792218169959675,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,uncertain,,-0.3277,0.0831,-22.2066,-6.53863952051996,0.711644119295423,Pathogenic,0.9014,pathogenic,-4.294,available,https://doi.org/10.1101/2022.10.22.513328 +Q136W,NP_000537:p.Gln136Trp,,,,,saturation_mutlist,,,,,,,,1.86523,1.416546378135681,,-0.700665668416185,,0.5822821657919075,,Neutral,Uncertain,,Neutral,0.22342648083910135,,0.1255667293496435,0.54968,,-0.7539782115930548,,-0.10214910579652742,,Neutral,,Neutral,,0.2430866916128617,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.3457,0.0831,-22.2066,-6.79269182513879,0.8665211210310053,Pathogenic,0.99,pathogenic,-4.706,available,https://doi.org/10.1101/2022.10.22.513328 +Q136Y,NP_000537:p.Gln136Tyr,,,,,saturation_mutlist,,,,,,,,1.21606,1.4276899576187134,,-0.2836270693246856,,0.46621646533765715,,Neutral,Uncertain,,Neutral,0.2056465096259442,,0.0781464054952289,-0.2683,,-0.2385651935946509,,-0.25343259679732544,,Neutral,,Neutral,,0.12451421133208487,34.176,5.819,39.855,8.065,,False,34.176,,neutral,neutral,neutral,,False,39.855,,neutral,neutral,neutral,damaging,,-0.3486,0.0831,-22.2066,-6.79269182513879,0.870762336145894,Pathogenic,0.9841,pathogenic,-4.638,available,https://doi.org/10.1101/2022.10.22.513328 +L137A,NP_000537:p.Leu137Ala,,,,,saturation_mutlist,,,,,,,,0.75152,0.2735528123378754,,1.5790801776031713,,1.1653000888015856,,Neutral,Neutral,,Neutral,0.3926297492933538,,0.36939354915269695,0.21639,,1.0693256040097217,,0.6428578020048609,,Neutral,,Neutral,,0.13517686576883323,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.3129,1.1568,-22.2066,-6.08868894034508,0.6763957743026042,Uncertain,0.9163,pathogenic,-3.908,available,https://doi.org/10.1101/2022.10.22.513328 +L137C,NP_000537:p.Leu137Cys,,,,,saturation_mutlist,,,,,,,,1.14653,0.02426094293594361,,1.8909989205858422,,1.5187644602929211,,Neutral,Neutral,,Neutral,0.2615460839185595,,0.20677069095247838,0.47192,,1.6705086631908437,,1.071214331595422,,Neutral,,Neutral,,0.08347582634846248,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.3021,1.1568,-22.2066,-6.08868894034508,0.8379447255653671,Pathogenic,0.979,pathogenic,-4.275,available,https://doi.org/10.1101/2022.10.22.513328 +L137D,NP_000537:p.Leu137Asp,,,,,saturation_mutlist,,,,,,,,1.49236,0.7982122778892518,,2.059425501456379,,1.7758927507281896,,Uncertain,Neutral,,Neutral,0.5148043450935182,,0.21784316245614221,0.17485,,1.3235654219724216,,0.7492077109862108,,Neutral,,Neutral,,0.3208647289595817,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.4344,1.1568,-22.2066,-6.5824339581492,0.8383206820472677,Pathogenic,0.9968,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328 +L137E,NP_000537:p.Leu137Glu,"hg19,17:g.7578520_7578521delinsTC, hg38,17:g.7675202_7675203delinsTC",,,,"ClinVar,saturation_mutlist",1713937,Uncertain significance,1,,,,,0.77002,0.2579011607170105,-3.322903333333333,1.5271381418380348,-1.2764416666666665,1.1485790709190173,Uncertain,Neutral,Neutral,Neutral,Neutral,0.44126036306166355,2.9170950521061565,0.2056814289577742,-0.04076,0.6878666666666667,1.0758040776002733,0.32355333333333336,0.5175220388001367,Neutral,Neutral,Neutral,Neutral,0.37398112130011174,0.27702076966920675,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.4025,1.1568,-22.2066,-6.5824339581492,0.8366984703838687,Pathogenic,0.98,pathogenic,-4.338,available,https://doi.org/10.1101/2022.10.22.513328 +L137F,NP_000537:p.Leu137Phe,,,,,saturation_mutlist,,,,,,,,0.33049,0.1469884395599365,,0.49124722453227426,,0.41086861226613713,,Neutral,Neutral,,Neutral,0.3717693548234039,,0.141927621148063,0.29846,,0.3466281370939012,,0.3225440685469506,,Neutral,,Neutral,,0.05703798009118532,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.2464,1.1568,-22.2066,-5.69912924308325,0.5603845899864934,Uncertain,0.9135,pathogenic,-3.865,available,https://doi.org/10.1101/2022.10.22.513328 +L137G,NP_000537:p.Leu137Gly,,,,,saturation_mutlist,,,,,,,,1.76593,0.9847477519512177,,2.7839142492631517,,2.274922124631576,,Uncertain,Neutral,,Uncertain,0.47759123067523596,,0.32041535079989014,-0.17592,,2.0544483978098564,,0.9392641989049282,,Uncertain,,Neutral,,0.26398498535398435,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.3877,1.1568,-22.2066,-6.95235868798953,0.8620186302619599,Pathogenic,0.9819,pathogenic,-4.32,available,https://doi.org/10.1101/2022.10.22.513328 +L137H,NP_000537:p.Leu137His,,,,,saturation_mutlist,,,,,,,,0.8672,0.37729942202568056,,1.055190231364833,,0.9611951156824164,,Neutral,Neutral,,Neutral,0.4258225473818892,,0.16520958110272482,0.95006,,0.6508456463133293,,0.8004528231566647,,Neutral,,Neutral,,0.16945219600797176,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.3553,1.1568,-22.2066,-6.41042875411472,0.8140609161149494,Pathogenic,0.976,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328 +L137I,NP_000537:p.Leu137Ile,,,,,saturation_mutlist,,,,,,,,1.05423,-0.2842596197128296,,0.4080065565446896,,0.7311182782723448,,Neutral,Neutral,,Neutral,0.18621270620340263,,0.10232683261116154,1.17449,,0.5015529615123638,,0.8380214807561819,,Neutral,,Neutral,,0.0775157999569781,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.0776,1.1568,-0.7691,-2.4694550821995,0.0027929738397298,Benign,0.3715,ambiguous,-3.183,available,https://doi.org/10.1101/2022.10.22.513328 +L137K,NP_000537:p.Leu137Lys,,,,,saturation_mutlist,,,,,,,,0.54348,0.22497446060180665,,1.6146871728190177,,1.0790835864095087,,Neutral,Neutral,,Neutral,0.3008140474112998,,0.12478860703749735,0.1616,,1.109926411612905,,0.6357632058064525,,Neutral,,Neutral,,0.2734525289092354,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.4015,1.1568,-22.2066,-4.75205378698714,0.1491637743739586,Benign,0.9115,pathogenic,-3.879,available,https://doi.org/10.1101/2022.10.22.513328 +L137M,NP_000537:p.Leu137Met,"hg38,17:g.7675203G>T",,,0.637,"COSMIC,saturation_mutlist",,,,,,,,0.31379,0.14566210031509397,0.07902666666666665,0.817750977625136,0.19640833333333332,0.5657704888125681,Neutral,Neutral,Neutral,Neutral,Neutral,0.1542687657995246,1.3210115115403886,0.12748006291193684,-0.06558,0.39172333333333337,0.6468313361176034,0.16307166666666667,0.2906256680588017,Neutral,Neutral,Neutral,Neutral,0.2056970032731531,0.1309490417167312,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.1248,1.1568,-5.4594,-0.737629429540157,0.000587075262993,Benign,0.3219,benign,-3.086,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L137N,NP_000537:p.Leu137Asn,,,,,saturation_mutlist,,,,,,,,1.37812,0.6868074369430542,,1.6908594943096213,,1.5344897471548107,,Neutral,Neutral,,Neutral,0.4364674915758223,,0.2496035773704616,0.73102,,1.126051432538876,,0.928535716269438,,Neutral,,Neutral,,0.17802518495046013,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.3807,1.1568,-22.2066,-6.5824339581492,0.7633185476228058,Pathogenic,0.9693,pathogenic,-4.111,available,https://doi.org/10.1101/2022.10.22.513328 +L137P,NP_000537:p.Leu137Pro,"hg38,17:g.7675202A>G",,,0.950,"COSMIC,saturation_mutlist",,,,,,,,1.53522,0.7533562934398651,4.1305000000000005,3.348480113031922,2.83286,2.441850056515961,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.4634156059049214,1.803667790771534,0.09231177714200982,-0.73878,-0.13106333333333334,2.1971677837685015,-0.43492166666666665,0.7291938918842508,Neutral,Uncertain,Neutral,Neutral,0.17187001141043257,0.6106288885838419,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.3963,1.1568,-22.2066,-4.98533951832152,0.2161250945982092,Benign,0.9377,pathogenic,-3.846,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L137Q,NP_000537:p.Leu137Gln,"hg19,17:g.7578520A>T, hg19,17:g.7675202A>T, hg38,17:g.7675202A>T",,,0.951,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3972459,Uncertain significance,1,,,,,0.93725,0.21431200027465822,-0.8316300000000001,1.491692195798713,0.05280999999999997,1.2144710978993565,Neutral,Neutral,Neutral,Neutral,Neutral,0.3743363272625247,1.0040950944009237,0.15685746638860631,0.41671,0.44943333333333335,1.0391146625896088,0.4330716666666667,0.7279123312948044,Neutral,Neutral,Neutral,Neutral,0.7359417972608673,0.2022450203646522,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.3337,1.1568,-22.2066,-6.23359532734253,0.6209150571251112,Uncertain,0.9075,pathogenic,-3.998,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L137R,NP_000537:p.Leu137Arg,,,,,saturation_mutlist,,,,,,,,0.80033,0.27748272657394407,,1.164548201911369,,0.9824391009556845,,Neutral,Neutral,,Neutral,0.28714321361267753,,0.2691212375505652,0.40378,,0.8119038399693378,,0.6078419199846689,,Neutral,,Neutral,,0.19131251720970038,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.3253,1.1568,-8.9187,-3.7612614386269,0.1280623138918843,Benign,0.8728,pathogenic,-3.804,available,https://doi.org/10.1101/2022.10.22.513328 +L137S,NP_000537:p.Leu137Ser,,,,,saturation_mutlist,,,,,,,,1.37397,0.4118600249290466,,1.9803269704666286,,1.6771484852333143,,Neutral,Neutral,,Neutral,0.43860574856658546,,0.3198523353373624,0.51851,,1.2629444951786437,,0.8907272475893219,,Neutral,,Neutral,,0.18729535746869985,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.3433,1.1568,-22.2066,-4.4456022084144,0.0010824790992534,Benign,0.9802,pathogenic,-3.793,available,https://doi.org/10.1101/2022.10.22.513328 +L137T,NP_000537:p.Leu137Thr,,,,,saturation_mutlist,,,,,,,,1.37713,0.1757788300514221,,1.4482603820198332,,1.4126951910099166,,Neutral,Neutral,,Neutral,0.32374572490974257,,0.2624561139000966,0.81697,,1.1098797784681715,,0.9634248892340858,,Neutral,,Neutral,,0.1205172304155908,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.316,1.1568,-22.2066,-6.08868894034508,0.6179440960651175,Uncertain,0.9389,pathogenic,-3.812,available,https://doi.org/10.1101/2022.10.22.513328 +L137V,NP_000537:p.Leu137Val,"hg19,17:g.7578521G>C, hg38,17:g.7675203G>C",,,0.731,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1005829,Uncertain significance,1,,,,,0.98003,-0.2810047650337219,0.6099766666666667,0.6139816916628615,0.7950033333333333,0.7970058458314307,Neutral,Neutral,Neutral,Neutral,Neutral,0.19948702170578145,0.0364782824278897,0.13916005239154228,0.97771,0.52449,0.7112432733446327,0.7511,0.8444766366723163,Neutral,Neutral,Neutral,Neutral,0.3209710000399828,0.024737239565194823,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.1504,1.1568,-7.9188,-2.4585383477174,0.0663916497189654,Benign,0.4695,ambiguous,-3.407,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L137W,NP_000537:p.Leu137Trp,,,,,saturation_mutlist,,,,,,,,0.78969,0.03747114419937134,,0.3113649127735137,,0.5505274563867568,,Neutral,Neutral,,Neutral,0.35935131997662473,,0.3019777881862863,0.56573,,0.020869686055878967,,0.29329984302793943,,Neutral,,Neutral,,0.03601717749975872,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.3455,1.1568,-22.2066,-6.41042875411472,0.7669160714452511,Pathogenic,0.9609,pathogenic,-4.279,available,https://doi.org/10.1101/2022.10.22.513328 +L137Y,NP_000537:p.Leu137Tyr,,,,,saturation_mutlist,,,,,,,,0.38819,0.11363818645477294,,0.6918214525480318,,0.5400057262740159,,Neutral,Neutral,,Neutral,0.41696297130679033,,0.17127838170218637,0.42716,,0.4994140097184361,,0.46328700485921803,,Neutral,,Neutral,,0.09727431456405614,32.515,4.834,40.17,8.695,,False,32.515,,neutral,neutral,neutral,,False,40.17,,neutral,neutral,neutral,uncertain,,-0.3384,1.1568,-22.2066,-6.41042875411472,0.8588307601369856,Pathogenic,0.972,pathogenic,-4.289,available,https://doi.org/10.1101/2022.10.22.513328 +A138C,NP_000537:p.Ala138Cys,,,,,saturation_mutlist,,,,,,,,-0.31913,-0.6958604764938354,,0.6724269639845032,,0.17664848199225158,,Neutral,Neutral,,Neutral,0.21236755904927554,,0.11990498247770744,0.45541,,0.679937882689186,,0.567673941344593,,Neutral,,Neutral,,0.12837322167061838,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.2521,0.2233,-8.9187,-2.60075011127951,0.566053613177317,Uncertain,0.8354,pathogenic,-4.164,available,https://doi.org/10.1101/2022.10.22.513328 +A138D,NP_000537:p.Ala138Asp,"hg19,17:g.7578517G>T, hg38,17:g.7675199G>T",,,0.901,"COSMIC,ClinVar,saturation_mutlist",528270,Uncertain significance,3,,,,,0.56055,-0.01362775325775146,-2.8522666666666665,0.3358826629855418,-1.1458583333333332,0.4482163314927709,Uncertain,Neutral,Neutral,Neutral,Neutral,0.15132581147448768,4.006368334284249,0.23171486132990562,0.23566,-0.03594000000000001,0.10963734083380376,0.09986,0.17264867041690188,Neutral,Neutral,Neutral,Neutral,0.7789778603186785,0.1638872717163312,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.4016,0.2233,-22.2066,-3.70793948350202,0.0426949165859065,Benign,0.9364,pathogenic,-3.904,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A138E,NP_000537:p.Ala138Glu,,,,,saturation_mutlist,,,,,,,,-0.41247,-0.09572003006935118,,0.22628204974391142,,-0.09309397512804429,,Neutral,Neutral,,Neutral,0.15116992481755842,,0.18119722320879844,0.0232,,0.07148975982280907,,0.047344879911404535,,Neutral,,Neutral,,0.23580672869434474,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.3143,0.2233,-7.9188,-4.02504115372283,0.0200507974556553,Benign,0.884,pathogenic,-3.841,available,https://doi.org/10.1101/2022.10.22.513328 +A138F,NP_000537:p.Ala138Phe,,,,,saturation_mutlist,,,,,,,,0.52433,-0.25137154817581175,,-0.512628990772936,,0.005850504613531982,,Neutral,Neutral,,Neutral,0.2554644961090871,,0.2229749811818522,0.28648,,-0.49625048376932823,,-0.10488524188466411,,Neutral,,Neutral,,0.164538525530787,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.37,0.2233,-22.2066,-7.05804875358714,0.56145932795437,Uncertain,0.8895,pathogenic,-4.346,available,https://doi.org/10.1101/2022.10.22.513328 +A138G,NP_000537:p.Ala138Gly,"hg19,17:g.7578517G>C, hg38,17:g.7675199G>C",,,0.842,"ClinVar,saturation_mutlist",1375764,Uncertain significance,3,,,,,-1.06397,-0.5976280534267425,-0.44750666666666666,0.9091705080603396,-0.7557383333333334,-0.07739974596983024,Neutral,Neutral,Neutral,Neutral,Neutral,0.23041203677486627,0.15320595665820425,0.20812129551956246,-0.25848,0.19762,0.7439211298806598,-0.03043,0.24272056494032992,Neutral,Neutral,Neutral,Neutral,0.5240221570379126,0.05128563301449106,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,neutral,,-0.2313,0.2233,-6.1115,-2.94024134866916,0.000251354592281,Benign,0.2073,benign,-3.394,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A138H,NP_000537:p.Ala138His,,,,,saturation_mutlist,,,,,,,,0.87105,-0.35647708773612974,,-0.35428598148808216,,0.2583820092559589,,Neutral,Neutral,,Neutral,0.19183577187229667,,0.17988665095100206,0.59312,,-0.41084438439399573,,0.09113780780300212,,Neutral,,Neutral,,0.12326714934398546,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.3741,0.2233,-22.2066,-6.63106118000632,0.7381829367000703,Pathogenic,0.9196,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +A138I,NP_000537:p.Ala138Ile,,,,,saturation_mutlist,,,,,,,,0.52227,0.5557169556617737,,0.0051400957784879,,0.263705047889244,,Neutral,Neutral,,Neutral,0.18092992227182952,,0.15865835119290356,0.42848,,-0.05322052465382237,,0.18762973767308883,,Neutral,,Neutral,,0.23398052075263398,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.3595,0.2233,-22.2066,-6.7213668870673,0.8166396584826955,Pathogenic,0.9865,pathogenic,-4.304,available,https://doi.org/10.1101/2022.10.22.513328 +A138K,NP_000537:p.Ala138Lys,,,,,saturation_mutlist,,,,,,,,-0.7711,-0.07944697618484495,,-0.057028834486178036,,-0.414064417243089,,Neutral,Neutral,,Neutral,0.1123087283012368,,0.17701770359617097,-0.12218,,-0.057266406888272205,,-0.0897232034441361,,Neutral,,Neutral,,0.11136350419430795,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.3919,0.2233,-22.2066,-5.44367088275368,0.5010461180494552,Uncertain,0.9621,pathogenic,-4.053,available,https://doi.org/10.1101/2022.10.22.513328 +A138L,NP_000537:p.Ala138Leu,,,,,saturation_mutlist,,,,,,,,-0.33919,-0.13869247436523438,,-0.5067557570172139,,-0.42297287850860693,,Neutral,Neutral,,Neutral,0.20275410760101664,,0.09392380327191555,-0.12093,,-0.5955828293484594,,-0.3582564146742297,,Neutral,,Neutral,,0.16497872067387812,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.3643,0.2233,-22.2066,-5.65679517439494,0.6878357773190119,Pathogenic,0.8123,pathogenic,-4.112,available,https://doi.org/10.1101/2022.10.22.513328 +A138M,NP_000537:p.Ala138Met,,,,,saturation_mutlist,,,,,,,,-1.0902,-0.2189459228515625,,-0.2132336926068471,,-0.6517168463034235,,Neutral,Neutral,,Neutral,0.13482555827383103,,0.09650838551288393,-0.39193,,-0.2998425677331132,,-0.3458862838665566,,Neutral,,Neutral,,0.13099703358572568,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.323,0.2233,-22.2066,-6.55434917449774,0.5460669597772883,Uncertain,0.8812,pathogenic,-4.117,available,https://doi.org/10.1101/2022.10.22.513328 +A138N,NP_000537:p.Ala138Asn,,,,,saturation_mutlist,,,,,,,,0.29682,-0.433521808385849,,-0.03402312559317244,,0.13139843720341376,,Neutral,Neutral,,Neutral,0.1639307698586741,,0.17754218853995937,-0.0895,,-0.0925604181127108,,-0.0910302090563554,,Neutral,,Neutral,,0.1109816143001411,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.372,0.2233,-22.2066,-4.71219397097115,0.0469210581647958,Benign,0.7196,pathogenic,-3.809,available,https://doi.org/10.1101/2022.10.22.513328 +A138P,NP_000537:p.Ala138Pro,"hg19,17:g.7578518C>G, hg19,17:g.7675200C>G, hg38,17:g.7675200C>G",,,0.949,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12376,Likely pathogenic,3,,,,,5.63821,1.1730124378204345,5.878683333333334,3.5633435763275716,5.758446666666667,4.6007767881637855,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.14600046827888263,3.321862812001055,0.39425955612925195,1.16606,2.417346666666667,2.378814313449943,1.7917033333333334,1.7724371567249717,Uncertain,Uncertain,Neutral,Neutral,3.100532453212226,0.4106122907114212,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.4413,0.2233,-22.2066,-7.56742875363704,0.7961553770657813,Pathogenic,0.9887,pathogenic,-4.297,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A138Q,NP_000537:p.Ala138Gln,,,,,saturation_mutlist,,,,,,,,-0.48293,-0.14041600704193116,,0.1372947127134929,,-0.17281764364325358,,Neutral,Neutral,,Neutral,0.10192708549520577,,0.128322270984771,-0.07625,,0.0640010614175579,,-0.006124469291221048,,Neutral,,Neutral,,0.11558146039987163,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.3695,0.2233,-22.2066,-5.09655753060162,0.6119058083787835,Uncertain,0.7173,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328 +A138R,NP_000537:p.Ala138Arg,,,,,saturation_mutlist,,,,,,,,-0.51642,0.014562724828720085,,-0.33741984937271097,,-0.4269199246863555,,Neutral,Neutral,,Neutral,0.11457397720166806,,0.09598684426808686,0.07137,,-0.2846761902184896,,-0.10665309510924481,,Neutral,,Neutral,,0.08887596422929137,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.4026,0.2233,-22.2066,-5.46389254293497,0.6214621882296107,Uncertain,0.8602,pathogenic,-4.152,available,https://doi.org/10.1101/2022.10.22.513328 +A138S,NP_000537:p.Ala138Ser,"hg38,17:g.7675200C>A",,,0.911,"COSMIC,saturation_mutlist",,,,,,,,-0.48883,0.11886317670345305,0.16201666666666667,0.514036915012864,-0.16340666666666664,0.012603457506431992,Neutral,Neutral,Neutral,Neutral,Neutral,0.05725902736514453,0.19150821328484988,0.18217700821398813,0.54517,-0.08945666666666667,0.2565984919549235,0.22785666666666668,0.40088424597746175,Neutral,Neutral,Neutral,Neutral,0.13528527496450685,0.11578177430311962,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,uncertain,,-0.2087,0.2233,-7.3339,-2.23612043909446,0.0073701632163356,Benign,0.174,benign,-3.44,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A138T,NP_000537:p.Ala138Thr,"hg19,17:g.7578518C>T, hg19,17:g.7675200C>T, hg38,17:g.7675200C>T",,,0.910,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1053218,Uncertain significance,3,,,,,0.9446,0.35082673013210297,0.6213166666666666,0.42243700268305195,0.7829583333333333,0.6835185013415259,Neutral,Neutral,Neutral,Neutral,Neutral,0.19975061829263616,0.24392842834642203,0.19685100411551576,0.77741,0.3927433333333333,0.2902698858403819,0.5850766666666667,0.533839942920191,Neutral,Neutral,Neutral,Neutral,0.8267764966959867,0.23145387534929623,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.2905,0.2233,-22.2066,-4.55908750981123,0.6577305988634715,Uncertain,0.7817,pathogenic,-3.829,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A138V,NP_000537:p.Ala138Val,"hg19,17:g.7578517G>A, hg19,17:g.7675199G>A, hg38,17:g.7675198_7675199delinsAA, hg38,17:g.7675199G>A",,0.0,0.870,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",184863,Likely pathogenic,3,Likely oncogenic,1,Tier I - Strong,1,1.04953,0.48574631989002226,3.524033333333333,-0.0397276250977028,2.2867816666666667,0.5049011874511486,Uncertain,Neutral,Neutral,Uncertain,Neutral,0.17577281956862115,0.1365708295679897,0.20622497046649182,0.80972,0.6574833333333333,0.07819223008195113,0.7336016666666667,0.44395611504097554,Neutral,Neutral,Neutral,Neutral,1.5217293636371598,0.23590855201754,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.2876,0.2233,-22.2066,-6.7213668870673,0.5095397216163231,Uncertain,0.9331,pathogenic,-4.076,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A138W,NP_000537:p.Ala138Trp,,,,,saturation_mutlist,,,,,,,,0.75825,0.02257776975631714,,-0.6716605099713098,,0.043294745014345104,,Neutral,Neutral,,Neutral,0.18699304817040802,,0.22508461276895514,0.60756,,-0.7690991932852261,,-0.08076959664261307,,Neutral,,Neutral,,0.11192120848542254,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.3809,0.2233,-22.2066,-7.05804875358714,0.8377557119604753,Pathogenic,0.9817,pathogenic,-4.63,available,https://doi.org/10.1101/2022.10.22.513328 +A138Y,NP_000537:p.Ala138Tyr,,,,,saturation_mutlist,,,,,,,,0.61858,-0.1368250012397766,,-0.3732891188421887,,0.12264544057890567,,Neutral,Neutral,,Neutral,0.2576856245148259,,0.265415298524875,0.3705,,-0.40899158051448303,,-0.01924579025724152,,Neutral,,Neutral,,0.12897139300397228,43.045,6.211,55.29,16.162,,True,43.045,,neutral,neutral,neutral,,True,55.29,,neutral,neutral,neutral,damaging,,-0.3892,0.2233,-22.2066,-7.05804875358714,0.7813545020179077,Pathogenic,0.9298,pathogenic,-4.496,available,https://doi.org/10.1101/2022.10.22.513328 +K139A,NP_000537:p.Lys139Ala,,,,,saturation_mutlist,,,,,,,,0.36862,0.32116246223449707,,0.2663174627445606,,0.31746873137228027,,Neutral,Neutral,,Neutral,0.2233803856217776,,0.09538931745749293,-0.04166,,0.22435420691040686,,0.09134710345520343,,Neutral,,Neutral,,0.3446330939383864,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3153,0.0758,-22.2066,-4.75847962272788,0.5241155240132733,Uncertain,0.9585,pathogenic,-3.97,available,https://doi.org/10.1101/2022.10.22.513328 +K139C,NP_000537:p.Lys139Cys,,,,,saturation_mutlist,,,,,,,,0.65496,0.11996534824371335,,0.6491982860483968,,0.6520791430241983,,Neutral,Neutral,,Neutral,0.1901876757578509,,0.14879552400953583,0.30183,,0.5544728526693993,,0.4281514263346996,,Neutral,,Neutral,,0.2117098960951563,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3855,0.0758,-22.2066,-4.83709909651191,0.6378070224822506,Uncertain,0.9748,pathogenic,-4.162,available,https://doi.org/10.1101/2022.10.22.513328 +K139D,NP_000537:p.Lys139Asp,,,,,saturation_mutlist,,,,,,,,0.34538,1.6515794944763185,,0.4349380190775989,,0.39015900953879945,,Neutral,Uncertain,,Neutral,0.27330153120205275,,0.23538221576437646,0.20663,,0.23378980588781353,,0.22020990294390677,,Neutral,,Neutral,,0.2164359105960568,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.4243,0.0758,-22.2066,-6.36344461990687,0.7970832941255395,Pathogenic,0.994,pathogenic,-4.438,available,https://doi.org/10.1101/2022.10.22.513328 +K139E,NP_000537:p.Lys139Glu,"hg19,17:g.7578515T>C, hg19,17:g.7675197T>C, hg38,17:g.7675197T>C",,,0.844,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",658923,Uncertain significance,2,,,,,0.32227,0.6950162100791931,0.8471666666666667,0.1664757489221145,0.5847183333333333,0.24437287446105727,Neutral,Neutral,Neutral,Neutral,Neutral,0.16407924547391473,0.2684720601643472,0.22604229455484148,0.23424,1.3190466666666667,0.17182060310075276,0.7766433333333334,0.20303030155037638,Neutral,Neutral,Neutral,Neutral,1.3686591254784939,0.17203821910844305,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3402,0.0758,-22.2066,-5.50675267393172,0.5092324730407694,Uncertain,0.9567,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K139F,NP_000537:p.Lys139Phe,,,,,saturation_mutlist,,,,,,,,0.41253,0.662748568058014,,-0.2018545439941495,,0.10533772800292525,,Neutral,Neutral,,Neutral,0.20794947153632026,,0.057793973609461834,0.73673,,-0.039327000364663196,,0.3487014998176684,,Neutral,,Neutral,,0.08087427756104991,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3865,0.0758,-22.2066,-7.26153898005645,0.8214464931494126,Pathogenic,0.9972,pathogenic,-4.624,available,https://doi.org/10.1101/2022.10.22.513328 +K139G,NP_000537:p.Lys139Gly,,,,,saturation_mutlist,,,,,,,,0.72621,1.0753607535362244,,1.0811032394207243,,0.9036566197103622,,Neutral,Uncertain,,Neutral,0.27723351815481323,,0.19939735430043276,-1.37958,,0.6879710251310991,,-0.34580448743445047,,Neutral,,Neutral,,0.2037832828249641,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3745,0.0758,-22.2066,-7.78578005565755,0.8701728717577566,Pathogenic,0.9722,pathogenic,-4.348,available,https://doi.org/10.1101/2022.10.22.513328 +K139H,NP_000537:p.Lys139His,,,,,saturation_mutlist,,,,,,,,0.68544,0.5265030360221863,,-0.12238787385281741,,0.2815260630735913,,Neutral,Neutral,,Neutral,0.15511367387872746,,0.0981659016230572,0.98069,,-0.08588974122777297,,0.4474001293861135,,Neutral,,Neutral,,0.12425931219727959,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3254,0.0758,-22.2066,-7.06339340036591,0.6453513576526843,Uncertain,0.8916,pathogenic,-4.034,available,https://doi.org/10.1101/2022.10.22.513328 +K139I,NP_000537:p.Lys139Ile,,,,,saturation_mutlist,,,,,,,,1.18106,0.7025381517410278,,-0.21530509184682203,,0.482877454076589,,Neutral,Neutral,,Neutral,0.2668349123490336,,0.12047692880576652,1.62689,,-0.11654865003291326,,0.7551706749835434,,Neutral,,Neutral,,0.43368634969877673,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3537,0.0758,-22.2066,-6.21901222752533,0.8396300425404963,Pathogenic,0.9804,pathogenic,-4.295,available,https://doi.org/10.1101/2022.10.22.513328 +K139L,NP_000537:p.Lys139Leu,,,,,saturation_mutlist,,,,,,,,0.09761,0.2952548575401306,,-0.4425113229578385,,-0.17245066147891924,,Neutral,Neutral,,Neutral,0.1302916772946117,,0.10430902624155378,0.22909,,-0.4830493537241611,,-0.12697967686208056,,Neutral,,Neutral,,0.17489394899834984,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3524,0.0758,-22.2066,-4.88349226758231,0.7338494748605879,Pathogenic,0.965,pathogenic,-4.17,available,https://doi.org/10.1101/2022.10.22.513328 +K139M,NP_000537:p.Lys139Met,,,,,saturation_mutlist,,,,,,,,0.28327,0.14661778450012206,,-0.10263102171463163,,0.0903194891426842,,Neutral,Neutral,,Neutral,0.12421942879939299,,0.07964449102827138,0.0606,,-0.12671948546737108,,-0.03305974273368554,,Neutral,,Neutral,,0.19904666445467864,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3254,0.0758,-22.2066,-5.51070077052122,0.8377482907472718,Pathogenic,0.9403,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +K139N,NP_000537:p.Lys139Asn,"hg19,17:g.7578513C>A, hg19,17:g.7578513C>G, hg19,17:g.7675195C>A, hg19,17:g.7675195C>G, hg38,17:g.7675195C>A, hg38,17:g.7675195C>G",,,0.730,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",584923,Uncertain significance,2,,,,,0.47704,0.900940990447998,0.5634933333333333,0.214185760614764,0.5202666666666667,0.345612880307382,Neutral,Neutral,Neutral,Neutral,Neutral,0.1790779065055042,0.4968810157595299,0.13220583255880197,0.19726,0.25703,-0.05706408254264903,0.22714499999999999,0.07009795872867548,Neutral,Neutral,Neutral,Neutral,0.48139547733646193,0.12253567812486733,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3336,0.0758,-22.2066,-5.9949319493192,0.557200039113269,Uncertain,0.9818,pathogenic,-3.98,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K139P,NP_000537:p.Lys139Pro,,,,,saturation_mutlist,,,,,,,,2.50974,2.8301057910919187,,3.2575068507293357,,2.883623425364668,,Uncertain,Destabilizing,,Uncertain,0.3468828272700334,,0.6332129833698987,4.69245,,3.0738542704576868,,3.883152135228843,,Destabilizing,,Destabilizing,,2.180761953030708,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.4897,0.0758,-22.2066,-7.78578005565755,0.865919751916198,Pathogenic,0.992,pathogenic,-4.37,available,https://doi.org/10.1101/2022.10.22.513328 +K139Q,NP_000537:p.Lys139Gln,"hg19,17:g.7578515T>G, hg38,17:g.7675197T>G",,,0.768,"COSMIC,ClinVar,saturation_mutlist",1692473,Uncertain significance,2,,,,,0.39066,0.002415232658386224,-0.4377533333333334,0.14703416327127813,-0.023546666666666688,0.2688470816356391,Neutral,Neutral,Neutral,Neutral,Neutral,0.07490176787615672,0.20983138188131492,0.15230003471529963,0.47875,-0.1455766666666667,0.14630165680758123,0.16658666666666666,0.3125258284037906,Neutral,Neutral,Neutral,Neutral,0.11643606438251376,0.15669036834163555,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.2468,0.0758,-8.9187,-3.759511359164,0.5850505375617158,Uncertain,0.772,pathogenic,-3.788,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K139R,NP_000537:p.Lys139Arg,"hg19,17:g.7578514T>C, hg38,17:g.7675196T>C",,,0.760,"COSMIC,ClinVar,saturation_mutlist",1500748,Uncertain significance,1,,,,,0.01932,0.21502901792526244,0.21224333333333334,-0.181885665821813,0.11578166666666667,-0.0812828329109065,Neutral,Neutral,Neutral,Neutral,Neutral,0.055278159408268523,0.20421469916623422,0.09860383357057194,0.46867,0.8750566666666667,-0.1746663216182207,0.6718633333333334,0.14700183919088963,Neutral,Neutral,Neutral,Neutral,1.4361088048457733,0.066669442798275,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.1731,0.0758,-7.3339,-2.05403664958797,0.0105463550704981,Benign,0.174,benign,-3.478,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K139S,NP_000537:p.Lys139Ser,,,,,saturation_mutlist,,,,,,,,0.47784,0.6586410975456238,,0.4644150921825887,,0.47112754609129437,,Neutral,Neutral,,Neutral,0.19997866463906627,,0.1007787461763962,0.04976,,0.37876080962751685,,0.2142604048137584,,Neutral,,Neutral,,0.31803396042274434,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3255,0.0758,-22.2066,-4.78891889475202,0.5331461738099135,Uncertain,0.9706,pathogenic,-3.887,available,https://doi.org/10.1101/2022.10.22.513328 +K139T,NP_000537:p.Lys139Thr,"hg19,17:g.7578514T>G, hg19,17:g.7675196T>G, hg38,17:g.7675196T>G",,,0.800,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1338658,Uncertain significance,2,,,,,0.96079,0.6663519477844239,0.31066,0.16238551116890856,0.635725,0.5615877555844543,Neutral,Neutral,Neutral,Neutral,Neutral,0.24324648598794293,0.012718131414113718,0.09149091159183292,1.48292,1.1927433333333333,0.3769080008809181,1.3378316666666668,0.929914000440459,Neutral,Neutral,Neutral,Neutral,1.5022572907979361,0.5204365056969804,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3373,0.0758,-22.2066,-4.58963231057883,0.4002054800686839,Uncertain,0.8955,pathogenic,-3.867,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K139V,NP_000537:p.Lys139Val,,,,,saturation_mutlist,,,,,,,,1.11462,0.5651188397407532,,-0.15776590491011352,,0.4784270475449432,,Neutral,Neutral,,Neutral,0.25392006393804933,,0.08050356523047257,1.52825,,-0.08830949423695461,,0.7199702528815227,,Neutral,,Neutral,,0.44117338368255604,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3376,0.0758,-22.2066,-5.00452799386083,0.2136197625434333,Benign,0.9295,pathogenic,-3.989,available,https://doi.org/10.1101/2022.10.22.513328 +K139W,NP_000537:p.Lys139Trp,,,,,saturation_mutlist,,,,,,,,0.95328,0.9399421501159668,,-0.4773504947549325,,0.23796475262253375,,Neutral,Neutral,,Neutral,0.226448732148394,,0.15108839926107448,1.06427,,-0.30840651494132115,,0.3779317425293395,,Neutral,,Neutral,,0.08628002111921451,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3955,0.0758,-22.2066,-7.26153898005645,0.8683746910360057,Pathogenic,0.9951,pathogenic,-4.611,available,https://doi.org/10.1101/2022.10.22.513328 +K139Y,NP_000537:p.Lys139Tyr,,,,,saturation_mutlist,,,,,,,,0.50724,0.8268976140022278,,-0.13188333231377927,,0.1876783338431104,,Neutral,Neutral,,Neutral,0.23627349447613707,,0.07208631432815005,0.77985,,0.07440852448080104,,0.42712926224040054,,Neutral,,Neutral,,0.09533791919640722,46.299,5.839,48.195,16.529,,True,46.299,,neutral,neutral,neutral,,True,48.195,,neutral,neutral,neutral,uncertain,,-0.3713,0.0758,-22.2066,-7.26153898005645,0.8688527728086746,Pathogenic,0.991,pathogenic,-4.488,available,https://doi.org/10.1101/2022.10.22.513328 +T140A,NP_000537:p.Thr140Ala,"hg19,17:g.7578512T>C, hg19,17:g.7675194T>C, hg38,17:g.7675194T>C",,,0.806,"cBioPortal,ClinVar,saturation_mutlist",644101,Uncertain significance,1,,,,,0.2996,0.1211442220211029,0.5826566666666667,0.1916391357684473,0.44112833333333334,0.24561956788422362,Neutral,Neutral,Neutral,Neutral,Neutral,0.18690702119525535,0.2852367919622027,0.055264984660652106,-0.38003,0.12653,0.6487359676913188,-0.12674999999999997,0.1343529838456594,Neutral,Neutral,Neutral,Neutral,0.3397988876772063,0.12438338362413587,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.2282,0.2014,-7.3339,-1.68949918052894,0.0006866635869329,Benign,0.559,ambiguous,-3.436,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T140C,NP_000537:p.Thr140Cys,,,,,saturation_mutlist,,,,,,,,0.33232,-0.045033359527587885,,0.5796528814525091,,0.4559864407262546,,Neutral,Neutral,,Neutral,0.08598927337569652,,0.11254324825113869,-0.42088,,0.9416764941268193,,0.26039824706340964,,Neutral,,Neutral,,0.04663678363774704,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.3399,0.2014,-22.2066,-4.43103998340895,0.7276086680460926,Pathogenic,0.9361,pathogenic,-4.134,available,https://doi.org/10.1101/2022.10.22.513328 +T140D,NP_000537:p.Thr140Asp,,,,,saturation_mutlist,,,,,,,,0.326,0.7531732404232026,,0.5728073216061564,,0.44940366080307825,,Neutral,Neutral,,Neutral,0.14122928823809733,,0.11436458568611854,0.26383,,0.9243496455545488,,0.5940898227772744,,Neutral,,Neutral,,0.37221299643001443,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.4197,0.2014,-22.2066,-6.00987719184112,0.7182427126081831,Pathogenic,0.9686,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +T140E,NP_000537:p.Thr140Glu,,,,,saturation_mutlist,,,,,,,,-0.17098,0.7232737159729004,,0.25853613830886896,,0.04377806915443448,,Neutral,Neutral,,Neutral,0.1260617446804657,,0.06468580356383814,-0.6632,,0.7183325656728311,,0.027566282836415545,,Neutral,,Neutral,,0.3741190547503737,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.395,0.2014,-22.2066,-6.30908586921817,0.8281102379953241,Pathogenic,0.9721,pathogenic,-4.252,available,https://doi.org/10.1101/2022.10.22.513328 +T140F,NP_000537:p.Thr140Phe,,,,,saturation_mutlist,,,,,,,,-0.30568,0.4053478765487671,,-0.43076154610861267,,-0.36822077305430634,,Neutral,Neutral,,Neutral,0.0824760862797687,,0.03272101564818351,-0.79175,,-0.13867447591839477,,-0.46521223795919736,,Neutral,,Neutral,,0.2816998322004293,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.4113,0.2014,-22.2066,-5.14317644782034,0.67069179225716,Uncertain,0.9683,pathogenic,-4.037,available,https://doi.org/10.1101/2022.10.22.513328 +T140G,NP_000537:p.Thr140Gly,,,,,saturation_mutlist,,,,,,,,1.12676,0.5649730396270752,,1.5197437761783112,,1.3232518880891555,,Neutral,Neutral,,Neutral,0.18320933690711505,,0.2417896923582149,0.09137,,1.6753370364563793,,0.8833535182281896,,Neutral,,Neutral,,0.12789680617690205,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.3776,0.2014,-22.2066,-7.36060391745808,0.8338484958366235,Pathogenic,0.8458,pathogenic,-4.214,available,https://doi.org/10.1101/2022.10.22.513328 +T140H,NP_000537:p.Thr140His,,,,,saturation_mutlist,,,,,,,,0.52337,0.23857489228248596,,-0.09819652502089543,,0.21258673748955229,,Neutral,Neutral,,Neutral,0.14928954183422855,,0.06732044325892071,0.07303,,0.201282588932018,,0.137156294466009,,Neutral,,Neutral,,0.312007080667776,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.3916,0.2014,-22.2066,-5.97812061244266,0.6439222219216326,Uncertain,0.9387,pathogenic,-4.139,available,https://doi.org/10.1101/2022.10.22.513328 +T140I,NP_000537:p.Thr140Ile,"hg19,17:g.7578511G>A, hg38,17:g.7675192_7675193delinsAA, hg38,17:g.7675193G>A",,,0.842,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.4264,-0.3057254695892334,-0.38650999999999996,-0.7981642167171921,-0.406455,-0.6122821083585961,Neutral,Neutral,Neutral,Neutral,Neutral,0.14467111185789025,0.3094487230544021,0.07488384113698121,-0.40009,-0.13911333333333334,-0.3925957647626694,-0.2696016666666667,-0.3963428823813347,Neutral,Neutral,Neutral,Neutral,0.4196165451403883,0.21774948088988205,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.33,0.2014,-22.2066,-4.78355061393865,0.1737498927935706,Benign,0.9262,pathogenic,-3.773,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T140K,NP_000537:p.Thr140Lys,,,,,saturation_mutlist,,,,,,,,-0.32131,-0.1494158673286438,,0.15263444368558585,,-0.08433777815720707,,Neutral,Neutral,,Neutral,0.22838853827741448,,0.14784599756193648,-1.0335,,0.6460352954702596,,-0.19373235226487023,,Neutral,,Neutral,,0.15593029145700127,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.3872,0.2014,-22.2066,-6.13539200512126,0.3848268626183547,Uncertain,0.9451,pathogenic,-3.924,available,https://doi.org/10.1101/2022.10.22.513328 +T140L,NP_000537:p.Thr140Leu,,,,,saturation_mutlist,,,,,,,,-0.49594,0.11583980202674864,,-0.7643392875099925,,-0.6301396437549962,,Neutral,Neutral,,Neutral,0.143848719445689,,0.09455305998685525,-0.97124,,-0.4273918907663206,,-0.6993159453831603,,Neutral,,Neutral,,0.3513688046988449,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.3141,0.2014,-8.9187,-4.1002935633788,0.0402969361810807,Benign,0.78,pathogenic,-3.846,available,https://doi.org/10.1101/2022.10.22.513328 +T140M,NP_000537:p.Thr140Met,,,,,saturation_mutlist,,,,,,,,-0.4418,0.20697123765945435,,-0.24420447256455424,,-0.3430022362822771,,Neutral,Neutral,,Neutral,0.10010295668547904,,0.07451271429676791,-0.99617,,-0.01391921681349344,,-0.5050446084067467,,Neutral,,Neutral,,0.2841662207193293,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.3489,0.2014,-22.2066,-5.818742562352,0.6694884499608523,Uncertain,0.7084,pathogenic,-3.927,available,https://doi.org/10.1101/2022.10.22.513328 +T140N,NP_000537:p.Thr140Asn,"hg19,17:g.7578511G>T, hg38,17:g.7675193G>T",,,0.783,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",185918,Conflicting classifications of pathogenicity,1,,,,,0.35287,0.3336119520664215,0.7739233333333333,0.21363948789870038,0.5633966666666667,0.2832547439493502,Neutral,Neutral,Neutral,Neutral,Neutral,0.18422494140444318,0.254568791532313,0.12936150666861543,-0.03362,0.4483,0.49378342926325497,0.20734,0.2300817146316275,Neutral,Neutral,Neutral,Neutral,0.1467796854699814,0.14445225177317944,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.2919,0.2014,-8.9187,-5.50005840003409,0.185744953581711,Benign,0.7784,pathogenic,-3.82,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T140P,NP_000537:p.Thr140Pro,,,,,saturation_mutlist,,,,,,,,-0.5359,-0.3103871536254883,-0.4858266666666667,0.9884448182196897,-0.5108633333333333,0.2262724091098448,Neutral,Neutral,Neutral,Neutral,Neutral,0.32462251189212754,0.2878674678080561,0.4873450803179325,0.27469,1.4020399999999997,1.9968656026173608,0.8383649999999998,1.1357778013086803,Neutral,Neutral,Neutral,Neutral,2.4830041907469,0.9351063997846842,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.3887,0.2014,-6.5969,-3.39200897491382,0.0008809714978606,Benign,0.3055,benign,-3.489,available,https://doi.org/10.1101/2022.10.22.513328 +T140Q,NP_000537:p.Thr140Gln,,,,,saturation_mutlist,,,,,,,,-0.00919,0.2965462028980255,,0.18787513831963434,,0.08934256915981717,,Neutral,Neutral,,Neutral,0.16600898510358192,,0.051249732669017306,-0.47365,,0.614758537792746,,0.070554268896373,,Neutral,,Neutral,,0.22248386593943797,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.3692,0.2014,-22.2066,-5.77115300528214,0.4551054152727653,Uncertain,0.9396,pathogenic,-3.875,available,https://doi.org/10.1101/2022.10.22.513328 +T140R,NP_000537:p.Thr140Arg,,,,,saturation_mutlist,,,,,,,,0.06603,-0.1017598843574524,,-0.2487951583527568,,-0.0913825791763784,,Neutral,Neutral,,Neutral,0.20285741699484566,,0.12092491112219414,-0.67502,,0.2078704646128694,,-0.23357476769356528,,Neutral,,Neutral,,0.08495684198044733,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.39,0.2014,-22.2066,-6.39457638814057,0.4860922417303724,Uncertain,0.9108,pathogenic,-3.938,available,https://doi.org/10.1101/2022.10.22.513328 +T140S,NP_000537:p.Thr140Ser,"hg19,17:g.7578512T>A, hg38,17:g.7675194T>A",,,0.835,"ClinVar,saturation_mutlist",1525853,Uncertain significance,2,,,,,0.74454,0.08288384199142457,1.0497733333333332,0.5897711651854637,0.8971566666666666,0.6671555825927318,Neutral,Neutral,Neutral,Neutral,Neutral,0.12139473509791834,0.17384861946213112,0.10698927844513988,-0.21523,0.48016,0.8860693745770938,0.132465,0.3354196872885469,Neutral,Neutral,Neutral,Neutral,0.34556996175400817,0.27608940209498495,40.914,7.443,37.13,12.775,,True,40.914,,neutral,,,,True,37.13,,neutral,,,uncertain,,-0.2,0.2014,-8.9187,-0.782318311586425,0.0175013996384052,Benign,0.6699,pathogenic,-3.436,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T140V,NP_000537:p.Thr140Val,,,,,saturation_mutlist,,,,,,,,-0.07384,-0.12666758060455321,,-0.6505840087426714,,-0.3622120043713357,,Neutral,Neutral,,Neutral,0.1283789670856517,,0.16382754305204753,-0.43295,,-0.38334378315367035,,-0.40814689157683515,,Neutral,,Neutral,,0.14219195057969847,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.3175,0.2014,-22.2066,-4.98885875201501,0.0456569944620872,Benign,0.7853,pathogenic,-3.724,available,https://doi.org/10.1101/2022.10.22.513328 +T140W,NP_000537:p.Thr140Trp,,,,,saturation_mutlist,,,,,,,,-0.30129,0.3110054111480713,,-0.7968581743237698,,-0.5490740871618849,,Neutral,Neutral,,Neutral,0.0759023829486015,,0.07753001184948616,-0.1962,,-0.29811983700888944,,-0.24715991850444474,,Neutral,,Neutral,,0.43358588435218065,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.4042,0.2014,-22.2066,-5.97812061244266,0.8240884917941717,Pathogenic,0.99,pathogenic,-4.41,available,https://doi.org/10.1101/2022.10.22.513328 +T140Y,NP_000537:p.Thr140Tyr,,,,,saturation_mutlist,,,,,,,,-0.26639,0.29162055492401123,,-0.31910418891506936,,-0.29274709445753466,,Neutral,Neutral,,Neutral,0.10964936374196955,,0.02521823725671872,-0.71381,,0.05423141706210997,,-0.329789291468945,,Neutral,,Neutral,,0.26150692975120343,40.914,7.443,37.13,12.775,,True,40.914,,uncertain,,,,True,37.13,,uncertain,,,uncertain,,-0.4128,0.2014,-22.2066,-5.18926166155829,0.717481821794647,Pathogenic,0.956,pathogenic,-4.128,available,https://doi.org/10.1101/2022.10.22.513328 +C141A,NP_000537:p.Cys141Ala,"hg38,17:g.7675189_7675191delinsCGC",,,,"COSMIC,saturation_mutlist",,,,,,,,0.88652,0.6926142048835754,-0.0012466666666666553,0.8795272161873394,0.4426366666666667,0.8830236080936698,Neutral,Neutral,Neutral,Neutral,Neutral,0.20563247039741078,0.49324687864079675,0.09641721356852025,-0.26061,0.24546333333333328,0.25848887378455965,-0.0075733333333333624,-0.0010605631077201805,Neutral,Neutral,Neutral,Neutral,0.06798215272326177,0.7514982097383515,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.4493,0.4684,-22.2096,-4.49506374661009,0.8703545760793197,Pathogenic,0.8948,pathogenic,-4.43,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C141D,NP_000537:p.Cys141Asp,,,,,saturation_mutlist,,,,,,,,1.83405,1.6273591089248658,,2.2662470152133047,,2.0501485076066523,,Uncertain,Uncertain,,Uncertain,0.26229808803363847,,0.044752165784973,2.69325,,2.1290496362746123,,2.4111498181373063,,Uncertain,,Uncertain,,0.945758634645707,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,uncertain,,-0.5565,0.4684,-22.2096,-6.82655872471399,0.8688299035137168,Pathogenic,0.9982,pathogenic,-4.699,available,https://doi.org/10.1101/2022.10.22.513328 +C141E,NP_000537:p.Cys141Glu,,,,,saturation_mutlist,,,,,,,,1.5035,1.5265276288986207,,2.372403124008746,,1.9379515620043732,,Uncertain,Uncertain,,Neutral,0.17477045757347565,,0.18213445304659392,4.54186,,2.0251946714239395,,3.2835273357119696,,Uncertain,,Destabilizing,,0.9695094981080514,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.5441,0.4684,-22.2096,-6.82655872471399,0.8689757481243963,Pathogenic,0.9992,pathogenic,-4.648,available,https://doi.org/10.1101/2022.10.22.513328 +C141F,NP_000537:p.Cys141Phe,"hg19,17:g.7578507_7578508delinsAA, hg19,17:g.7578508C>A, hg19,17:g.7675190C>A, hg38,17:g.7675190C>A",,,0.880,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376568,Conflicting classifications of pathogenicity,1,,,,,4.10312,-0.2597054648399353,2.4726766666666666,0.7233733001268713,3.287898333333333,2.4132466500634355,Uncertain,Uncertain,Neutral,Destabilizing,Uncertain,0.30311138983252467,1.772383926849811,0.5790131816240873,13.76789,2.29388,1.3025262778708206,8.030885,7.53520813893541,Uncertain,Uncertain,Destabilizing,Destabilizing,2.9660305418634287,1.3491359533437441,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.4432,0.4684,-22.2096,-5.3511347302336,0.6024816669374561,Uncertain,0.8882,pathogenic,-3.883,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C141G,NP_000537:p.Cys141Gly,"hg19,17:g.7578509A>C, hg19,17:g.7675191A>C, hg38,17:g.7675191A>C",,,0.859,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.18573,1.598682975769043,5.3045366666666665,2.934346611839573,3.7451333333333334,2.5600383059197864,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.18717172696537682,0.9109171128166504,0.32795831845042606,0.16471,4.8641733333333335,2.2303671188310914,2.514441666666667,1.1975385594155457,Uncertain,Uncertain,Uncertain,Neutral,1.0034696899701996,1.1883393148185724,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.4417,0.4684,-22.2096,-7.47567734522593,0.8680326424448317,Pathogenic,0.906,pathogenic,-4.494,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C141H,NP_000537:p.Cys141His,,,,,saturation_mutlist,,,,,,,,4.04113,1.2060612559318542,,1.3606353284939203,,2.70088266424696,,Uncertain,Uncertain,,Uncertain,0.19483279213207363,,0.2872145124027731,12.15172,,1.6345686480601265,,6.893144324030063,,Uncertain,,Destabilizing,,1.1213160704205725,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.555,0.4684,-22.2096,-6.35585448522327,0.8633302157056174,Pathogenic,0.9922,pathogenic,-4.4,available,https://doi.org/10.1101/2022.10.22.513328 +C141I,NP_000537:p.Cys141Ile,,,,,saturation_mutlist,,,,,,,,-1.21264,-0.5888401937484741,,-0.3582172868683981,,-0.785428643434199,,Neutral,Neutral,,Neutral,0.41620677762036495,,0.3840545049469289,3.30741,,0.5341402238527486,,1.9207751119263743,,Uncertain,,Neutral,,0.8634087608843823,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.4731,0.4684,-22.2096,-5.49239420312258,0.4672364226767995,Uncertain,0.8966,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328 +C141K,NP_000537:p.Cys141Lys,,,,,saturation_mutlist,,,,,,,,3.28566,1.6238103675842286,,3.009140317539655,,3.1474001587698277,,Destabilizing,Uncertain,,Destabilizing,0.13545949002088806,,0.7582581387888517,7.29001,,3.573087066488299,,5.4315485332441495,,Destabilizing,,Destabilizing,,1.334102553342828,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.5447,0.4684,-22.2096,-7.47567734522593,0.8698044608588901,Pathogenic,0.9995,pathogenic,-4.652,available,https://doi.org/10.1101/2022.10.22.513328 +C141L,NP_000537:p.Cys141Leu,,,,,saturation_mutlist,,,,,,,,-1.41653,-0.43855249643325805,,-0.4459264892454294,,-0.9312282446227147,,Neutral,Neutral,,Neutral,0.48063271993243645,,0.14027534625172944,1.88804,,-0.1751950300471786,,0.8564224849764107,,Neutral,,Neutral,,0.751550970244482,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.5062,0.4684,-22.2096,-5.38272014387504,0.4072452385493216,Uncertain,0.9124,pathogenic,-3.872,available,https://doi.org/10.1101/2022.10.22.513328 +C141M,NP_000537:p.Cys141Met,,,,,saturation_mutlist,,,,,,,,-1.38992,-0.23467418432235718,,0.5406678964280308,,-0.4246260517859846,,Neutral,Neutral,,Neutral,0.25958628501199554,,0.3113861518638109,1.96528,,0.31323797323726665,,1.1392589866186333,,Neutral,,Neutral,,0.7381350979691034,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.4734,0.4684,-22.2096,-5.80371148438467,0.8141239622858947,Pathogenic,0.9493,pathogenic,-4.265,available,https://doi.org/10.1101/2022.10.22.513328 +C141N,NP_000537:p.Cys141Asn,,,,,saturation_mutlist,,,,,,,,0.94241,1.5098307514190674,,1.108748862279162,,1.025579431139581,,Neutral,Uncertain,,Neutral,0.18966885086889862,,0.06855493944332994,2.84762,,0.8890790785971543,,1.8683495392985772,,Uncertain,,Neutral,,0.6612390960227009,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.4311,0.4684,-8.9217,-4.89443162511126,0.2287624892146604,Benign,0.977,pathogenic,-4.093,available,https://doi.org/10.1101/2022.10.22.513328 +C141P,NP_000537:p.Cys141Pro,,,,,saturation_mutlist,,,,,,,,5.43145,1.674891529083252,,5.21944567942989,,5.325447839714945,,Destabilizing,Uncertain,,Destabilizing,0.21520679079786423,,0.5227383219901356,4.23262,,7.435668977580096,,5.834144488790048,,Destabilizing,,Destabilizing,,0.6855795075501045,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,uncertain,,-0.5676,0.4684,-22.2096,-7.47567734522593,0.8695610531756939,Pathogenic,0.9983,pathogenic,-4.56,available,https://doi.org/10.1101/2022.10.22.513328 +C141Q,NP_000537:p.Cys141Gln,,,,,saturation_mutlist,,,,,,,,1.29687,1.2408521151542664,,1.522117529278878,,1.409493764639439,,Neutral,Uncertain,,Neutral,0.19871678672332874,,0.15738805422974647,4.48807,,1.098115279721468,,2.793092639860734,,Uncertain,,Uncertain,,0.7375238300482057,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.5229,0.4684,-22.2096,-6.82655872471399,0.8268460487233154,Pathogenic,0.9951,pathogenic,-4.425,available,https://doi.org/10.1101/2022.10.22.513328 +C141R,NP_000537:p.Cys141Arg,"hg19,17:g.7578509A>G, hg19,17:g.7675191A>G, hg38,17:g.7675191A>G",,,0.861,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376565,Conflicting classifications of pathogenicity,1,,,,,7.81149,1.6429321193695068,8.039906666666665,2.13520847943609,7.925698333333333,4.973349239718045,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.15212022836215397,2.3492696561177384,0.6599603561117267,11.80401,3.783673333333333,2.454710825205615,7.793841666666666,7.129360412602807,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.8825377733307259,1.1825019257999863,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.5015,0.4684,-22.2096,-7.47567734522593,0.8708528671286377,Pathogenic,0.9943,pathogenic,-4.416,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C141S,NP_000537:p.Cys141Ser,"hg19,17:g.7578508C>G, hg19,17:g.7578509A>T, hg19,17:g.7675190C>G, hg38,17:g.7675190C>G, hg38,17:g.7675191A>T",,,"0.790, 0.813","cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.78027,0.9784713745117187,1.37245,1.7669596204278104,1.57636,1.773614810213905,Neutral,Neutral,Neutral,Neutral,Neutral,0.2926958440804113,0.5471629594554076,0.18166420504537428,0.86609,1.4822,1.489401753659935,1.174145,1.1777458768299676,Neutral,Neutral,Neutral,Neutral,0.10650043223699453,0.7276872117344999,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.3477,0.4684,-4.1145,-2.43914295419929,0.0016618166437629,Benign,0.8319,pathogenic,-3.728,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C141T,NP_000537:p.Cys141Thr,,,,,saturation_mutlist,,,,,,,,0.74888,0.7673116040229797,,0.8411931752650751,,0.7950365876325376,,Neutral,Neutral,,Neutral,0.413860714924438,,0.33325597560601083,1.82907,,0.8789949394496134,,1.3540324697248067,,Neutral,,Neutral,,0.2500319109389704,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.3926,0.4684,-6.1145,-2.49849240637548,0.0681571255012605,Benign,0.8897,pathogenic,-3.966,available,https://doi.org/10.1101/2022.10.22.513328 +C141V,NP_000537:p.Cys141Val,,,,,saturation_mutlist,,,,,,,,-0.85834,-0.3190002965927124,,-0.36324276240501163,,-0.6107913812025059,,Neutral,Neutral,,Neutral,0.3027268765002634,,0.41169427838784467,1.64509,,0.14540888536570082,,0.8952494426828503,,Neutral,,Neutral,,0.32908839118493,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.4712,0.4684,-22.2096,-3.09081985626779,0.4041984094139376,Uncertain,0.7556,pathogenic,-3.88,available,https://doi.org/10.1101/2022.10.22.513328 +C141W,NP_000537:p.Cys141Trp,"hg19,17:g.7578507G>C, hg19,17:g.7675189G>C, hg38,17:g.7675189G>C",,,0.808,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376564,Pathogenic,2,,,Tier I - Strong,1,11.63515,0.23945386648178102,5.952723333333334,1.8851302234907497,8.793936666666667,6.7601401117453745,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,0.3328184986763484,2.405664535526283,0.05657990955678161,24.01076,3.7236966666666667,2.03899926653735,13.867228333333333,13.024879633268675,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.8149832797603206,1.6278982788287142,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.4464,0.4684,-22.2096,-6.35585448522327,0.8408086220705873,Pathogenic,0.9877,pathogenic,-4.355,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C141Y,NP_000537:p.Cys141Tyr,"hg19,17:g.7578508C>T, hg19,17:g.7675190C>T, hg38,17:g.7675190C>T",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",140801,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,7.18438,0.35598392963409425,5.08787,1.579933994116195,6.136125,4.382156997058098,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,0.23300525359443472,2.2160140000009028,0.4845573779024748,19.60113,4.681633333333333,2.2225593319376755,12.141381666666668,10.911844665968838,Destabilizing,Uncertain,Destabilizing,Destabilizing,2.4117375323244072,1.4839386101512633,0.35,0.621,0.485,0.67,,True,0.35,,neutral,neutral,neutral,,True,0.485,,neutral,neutral,neutral,neutral,,-0.3847,0.4684,-8.9217,-2.49137110623133,0.8675460438380658,Pathogenic,0.9774,pathogenic,-4.352,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142A,NP_000537:p.Pro142Ala,"hg19,17:g.7578506G>C, hg38,17:g.7675188G>C",,,0.901,"COSMIC,ClinVar,saturation_mutlist",3809688,Uncertain significance,1,,,,,1.34988,0.8907198023796081,1.4680266666666666,-0.22148896413292518,1.4089533333333333,0.5641955179335374,Neutral,Neutral,Neutral,Neutral,Neutral,0.5077055294289693,0.4602226639597644,0.09682144807626553,1.66887,0.8783466666666667,0.2197577223140059,1.2736083333333335,0.944313861157003,Neutral,Neutral,Neutral,Neutral,0.7363158337893385,0.22763093656187366,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3162,0.1232,-22.2096,-6.68937636218592,0.6917196255738904,Pathogenic,0.6572,pathogenic,-4.032,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142C,NP_000537:p.Pro142Cys,,,,,saturation_mutlist,,,,,,,,1.65842,0.5544876837730408,,0.519360503140668,,1.088890251570334,,Neutral,Neutral,,Neutral,0.3575454674098644,,0.11260498771622443,2.42159,,0.75128116373412,,1.5864355818670601,,Uncertain,,Neutral,,0.29931495080867254,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3489,0.1232,-22.2096,-7.06923434007735,0.86164411926317,Pathogenic,0.9781,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +P142D,NP_000537:p.Pro142Asp,,,,,saturation_mutlist,,,,,,,,3.25986,2.1123961448669433,,0.26831065587285874,,1.7640853279364295,,Uncertain,Destabilizing,,Neutral,0.51505871310746,,0.29918571323817544,3.63672,,0.1342645248517325,,1.8854922624258663,,Uncertain,,Neutral,,0.22228217125315355,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3748,0.1232,-22.2096,-7.2245436950871,0.8551026739346033,Pathogenic,0.9952,pathogenic,-4.532,available,https://doi.org/10.1101/2022.10.22.513328 +P142E,NP_000537:p.Pro142Glu,,,,,saturation_mutlist,,,,,,,,1.67777,1.445092351436615,,-0.010049141648103202,,0.8338604291759484,,Neutral,Uncertain,,Neutral,0.5267620040906623,,0.16334052079870937,2.28804,,-0.006648326983814706,,1.1406958365080926,,Uncertain,,Neutral,,0.24052671733295566,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3586,0.1232,-22.2096,-7.2245436950871,0.8373644554961168,Pathogenic,0.9805,pathogenic,-4.448,available,https://doi.org/10.1101/2022.10.22.513328 +P142F,NP_000537:p.Pro142Phe,"hg19,17:g.7578505_7578506delinsAA, hg38,17:g.7675187_7675188delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.79195,0.7934300637245179,1.5471666666666666,-0.38836218430456443,2.1695583333333333,1.2017939078477178,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.46102736735805044,1.6213459005269526,0.2885240349330222,5.04939,-0.33582666666666666,-0.5056395131816172,2.3567816666666666,2.271875243409191,Uncertain,Uncertain,Uncertain,Uncertain,0.22531074960793346,0.21870522615994303,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3773,0.1232,-22.2096,-7.11434995405517,0.8509624119019747,Pathogenic,0.9934,pathogenic,-4.552,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142G,NP_000537:p.Pro142Gly,,,,,saturation_mutlist,,,,,,,,2.26964,1.6779375576972961,,0.9051031576121011,,1.5873715788060505,,Uncertain,Uncertain,,Neutral,0.44294761427468454,,0.16021650698247322,2.3067,,1.2306370026262934,,1.768668501313147,,Uncertain,,Neutral,,0.3855862205325821,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3306,0.1232,-22.2096,-7.91085924218022,0.8678062587772928,Pathogenic,0.9686,pathogenic,-4.38,available,https://doi.org/10.1101/2022.10.22.513328 +P142H,NP_000537:p.Pro142His,"hg38,17:g.7675187G>T",,,0.914,"COSMIC,saturation_mutlist",,,,,,,,4.04224,1.2306370449066162,2.3747166666666666,-0.2670913842743044,3.208478333333333,1.8875743078628475,Uncertain,Uncertain,Uncertain,Destabilizing,Neutral,0.5853094519348802,1.3039644270539832,0.13602245373231867,5.20619,0.7112266666666666,-0.3173841193591294,2.9587083333333335,2.4444029403204355,Uncertain,Uncertain,Uncertain,Uncertain,0.710995206000403,0.21183321244681755,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3549,0.1232,-22.2096,-6.89061955736869,0.0928330591734472,Benign,0.9499,pathogenic,-4.065,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142I,NP_000537:p.Pro142Ile,,,,,saturation_mutlist,,,,,,,,1.21768,0.7215520048141479,,-0.2800339215938452,,0.46882303920307744,,Neutral,Neutral,,Neutral,0.4037521016820354,,0.31787505466483673,2.39559,,-0.4347338383574817,,0.9804280808212591,,Uncertain,,Neutral,,0.10911338432254973,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3603,0.1232,-22.2096,-6.6210502474622,0.8168382547942192,Pathogenic,0.9726,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +P142K,NP_000537:p.Pro142Lys,,,,,saturation_mutlist,,,,,,,,1.12501,1.0515584111213685,,0.27121860735152364,,0.6981143036757619,,Neutral,Uncertain,,Neutral,0.4243928818153922,,0.23325175717877097,1.86535,,0.11077710420648419,,0.9880635521032421,,Neutral,,Neutral,,0.2451093750974468,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.2722,0.1232,-6.9218,-4.83433291949262,0.0204288664631773,Benign,0.9794,pathogenic,-4.001,available,https://doi.org/10.1101/2022.10.22.513328 +P142L,NP_000537:p.Pro142Leu,"hg19,17:g.7578505G>A, hg38,17:g.7675187G>A",,3.9800678204e-06,0.879,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",864520,Conflicting classifications of pathogenicity,1,,,,,1.04546,0.8666141963005066,1.1517033333333333,-0.5539370356924358,1.0985816666666666,0.24576148215378213,Neutral,Neutral,Neutral,Neutral,Neutral,0.4254800413860546,0.814628795682767,0.285389389278208,1.84385,-0.0029499999999999943,-0.7433359817778832,0.92045,0.5502570091110583,Neutral,Neutral,Neutral,Neutral,0.20736772764021566,0.1923728770093801,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.289,0.1232,-7.3368,-4.58121343403265,0.2239602580117152,Benign,0.8091,pathogenic,-3.843,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142M,NP_000537:p.Pro142Met,,,,,saturation_mutlist,,,,,,,,0.98733,0.8996468734741211,,-0.3224244190552363,,0.33245279047238185,,Neutral,Neutral,,Neutral,0.4159147300297402,,0.17843301464421132,1.52978,,-0.314032432940353,,0.6078737835298235,,Neutral,,Neutral,,0.12888145109415178,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3159,0.1232,-22.2096,-6.6210502474622,0.5065179429060667,Uncertain,0.958,pathogenic,-4.283,available,https://doi.org/10.1101/2022.10.22.513328 +P142N,NP_000537:p.Pro142Asn,,,,,saturation_mutlist,,,,,,,,3.02236,1.656527943611145,,0.0773004810212798,,1.54983024051064,,Uncertain,Uncertain,,Neutral,0.4932171825645355,,0.16311302928375862,3.54015,,-0.08091178911650321,,1.7296191054417485,,Uncertain,,Neutral,,0.16452784739426618,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3429,0.1232,-22.2096,-6.8749353022228,0.7917373049770209,Pathogenic,0.99,pathogenic,-4.173,available,https://doi.org/10.1101/2022.10.22.513328 +P142Q,NP_000537:p.Pro142Gln,,,,,saturation_mutlist,,,,,,,,1.56599,1.301850118637085,,0.04161392809352883,,0.8038019640467644,,Neutral,Uncertain,,Neutral,0.5261833485390792,,0.07260880312865414,2.38594,,0.12801182409702497,,1.2569759120485127,,Uncertain,,Neutral,,0.19909362702347005,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3446,0.1232,-22.2096,-6.95843459535208,0.7123606444264704,Pathogenic,0.9289,pathogenic,-4.054,available,https://doi.org/10.1101/2022.10.22.513328 +P142R,NP_000537:p.Pro142Arg,"hg19,17:g.7578505G>C, hg19,17:g.7675187G>C",,,0.907,"cBioPortal,saturation_mutlist",,,,,,,,1.48811,1.0924065828323364,2.0684766666666667,-0.018042024751505792,1.7782933333333335,0.7350339876242471,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.4406689942953375,0.5718862248345868,0.25140984535391625,2.09844,1.1716533333333334,-0.1650942928496287,1.6350466666666668,0.9666728535751857,Uncertain,Uncertain,Neutral,Neutral,0.5757462679765184,0.16837174186674708,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.386,0.1232,-22.2096,-7.02887704815977,0.4914263239347376,Uncertain,0.9261,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142S,NP_000537:p.Pro142Ser,"hg19,17:g.7578506G>A, hg38,17:g.7675188G>A",,,0.887,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",824720,Uncertain significance,2,,,,,2.56859,1.2998092722892762,2.262356666666667,0.21760737489217608,2.4154733333333334,1.393098687446088,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.49833002193929476,0.5212201132812212,0.22289489877138263,2.78872,1.61553,0.38500643671714685,2.202125,1.5868632183585736,Uncertain,Uncertain,Uncertain,Neutral,0.8390496889139919,0.21917756148091141,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3159,0.1232,-22.2096,-6.24313249476341,0.3751484077586338,Uncertain,0.8928,pathogenic,-3.922,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142T,NP_000537:p.Pro142Thr,"hg19,17:g.7578506G>T, hg38,17:g.7675188G>T",,,0.891,"COSMIC,ClinVar,saturation_mutlist",3972446,Uncertain significance,1,,,,,2.24097,1.2121413493156432,2.1802733333333335,0.08520035220707232,2.2106216666666665,1.1630851761035361,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.49905924606680885,0.5013015002526479,0.15160346779140924,3.34154,1.2967133333333332,0.21393368367095242,2.3191266666666666,1.7777368418354762,Uncertain,Uncertain,Uncertain,Neutral,0.17700066540992312,0.2091350304271831,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.328,0.1232,-22.2096,-7.06923434007735,0.6110879105811937,Uncertain,0.8496,pathogenic,-3.993,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142V,NP_000537:p.Pro142Val,,,,,saturation_mutlist,,,,,,,,1.45294,0.6874969220161438,,-0.289813215899734,,0.581563392050133,,Neutral,Neutral,,Neutral,0.44251762403468925,,0.2596878308839989,2.47521,,-0.2518573727167169,,1.1116763136416417,,Uncertain,,Neutral,,0.11314983807579283,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3157,0.1232,-22.2096,-6.6210502474622,0.8054277960443847,Pathogenic,0.9207,pathogenic,-4.169,available,https://doi.org/10.1101/2022.10.22.513328 +P142W,NP_000537:p.Pro142Trp,,,,,saturation_mutlist,,,,,,,,3.30268,0.7426393246650695,,-0.6840875568017223,,1.3092962215991388,,Uncertain,Neutral,,Neutral,0.5234193581020344,,0.39589343976197927,4.95681,,-0.8126512930500592,,2.07207935347497,,Uncertain,,Uncertain,,0.18790061521216322,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3898,0.1232,-22.2096,-7.11434995405517,0.8512998771061207,Pathogenic,0.995,pathogenic,-4.668,available,https://doi.org/10.1101/2022.10.22.513328 +P142Y,NP_000537:p.Pro142Tyr,,,,,saturation_mutlist,,,,,,,,3.17127,0.7125232434272766,,-0.13395066441855455,,1.5186596677907227,,Uncertain,Neutral,,Neutral,0.563609142010146,,0.27125103096112424,5.11829,,-0.3276690288626236,,2.395310485568688,,Uncertain,,Uncertain,,0.22362818827388756,13.769,5.69,17.94,8.458,,True,13.769,,neutral,neutral,neutral,,True,17.94,,neutral,neutral,neutral,uncertain,,-0.3783,0.1232,-22.2096,-7.11434995405517,0.851405311774105,Pathogenic,0.993,pathogenic,-4.387,available,https://doi.org/10.1101/2022.10.22.513328 +V143A,NP_000537:p.Val143Ala,"hg19,17:g.7578502A>G, hg19,17:g.7675184A>G, hg38,17:g.7675184A>G",,,0.574,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",804214,Pathogenic,3,,,,,3.1698,2.3691560220718384,2.890473333333334,2.6002047199802396,3.030136666666667,2.8850023599901196,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,0.27949909744524143,0.3528401409829795,0.24379175881303478,0.02606,2.4619033333333333,2.116844272391852,1.2439816666666668,1.0714521361959262,Uncertain,Uncertain,Neutral,Neutral,0.33572657548798385,0.3761786934344164,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,uncertain,,-0.2549,1.0422,-22.2096,-5.41695611372048,0.5729001861951852,Uncertain,0.9245,pathogenic,-3.942,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V143C,NP_000537:p.Val143Cys,,,,,saturation_mutlist,,,,,,,,2.15838,1.3147726774215698,,2.4461931322851935,,2.302286566142597,,Uncertain,Uncertain,,Uncertain,0.21879503252564933,,0.14432872848852032,0.14251,,2.2787188149368998,,1.21061440746845,,Uncertain,,Neutral,,0.13767670894220713,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,uncertain,,-0.2828,1.0422,-22.2096,-6.58221124789451,0.8616209873815309,Pathogenic,0.9765,pathogenic,-4.307,available,https://doi.org/10.1101/2022.10.22.513328 +V143D,NP_000537:p.Val143Asp,,,,,saturation_mutlist,,,,,,,,3.38297,3.5010134506225588,,3.8499789578481436,,3.6164744789240717,,Destabilizing,Destabilizing,,Destabilizing,0.22954185142912054,,0.20903396782376488,2.42281,,3.3553806824978145,,2.8890953412489075,,Uncertain,,Uncertain,,0.310060303511668,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,uncertain,,-0.4215,1.0422,-22.2096,-7.13843299043174,0.8581243590003009,Pathogenic,0.9995,pathogenic,-4.729,available,https://doi.org/10.1101/2022.10.22.513328 +V143E,NP_000537:p.Val143Glu,"hg19,17:g.7578502A>T, hg19,17:g.7675184A>T, hg38,17:g.7675184A>T",,,0.683,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2687706,Uncertain significance,0,,,,,3.19166,3.3430129718780517,3.87551,3.473345098977521,3.533585,3.3325025494887606,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.23640888929172674,0.4380158793925169,0.1667603914117727,3.08037,4.237073333333333,2.7641747321992667,3.6587216666666666,2.9222723660996333,Destabilizing,Uncertain,Destabilizing,Uncertain,0.8595974256333927,0.41016721024786573,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,uncertain,,-0.3788,1.0422,-22.2096,-7.13843299043174,0.8429763782590516,Pathogenic,0.997,pathogenic,-4.671,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V143F,NP_000537:p.Val143Phe,,,,,saturation_mutlist,,,,,,,,4.14117,1.8770114183425903,,1.2625880189683747,,2.701879009484187,,Uncertain,Uncertain,,Uncertain,0.44915627726157625,,0.2892588372812039,4.72403,,0.36420794639566556,,2.5441189731978326,,Uncertain,,Uncertain,,0.8455508819671261,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,neutral,,-0.3321,1.0422,-22.2096,-4.98535794148785,0.0222921461268485,Benign,0.8238,pathogenic,-3.648,available,https://doi.org/10.1101/2022.10.22.513328 +V143G,NP_000537:p.Val143Gly,"hg19,17:g.7578502A>C, hg19,17:g.7675184A>C, hg38,17:g.7675184A>C",,,0.692,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",486556,Conflicting classifications of pathogenicity,1,,,,,4.66748,3.1517412757873533,5.238433333333334,4.655278323422915,4.952956666666667,4.661379161711458,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.3103781656051779,0.5237796903491223,0.43869984070184637,0.43139,4.87143,4.018358763987106,2.6514100000000003,2.224874381993553,Uncertain,Uncertain,Uncertain,Uncertain,0.3698969021227402,0.5502655597233983,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,uncertain,,-0.3807,1.0422,-22.2096,-7.13843299043174,0.8544908051467128,Pathogenic,0.9773,pathogenic,-4.532,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V143H,NP_000537:p.Val143His,,,,,saturation_mutlist,,,,,,,,4.7218,3.1199318408966064,,2.3264990228649416,,3.524149511432471,,Uncertain,Destabilizing,,Destabilizing,0.3815771923228317,,0.2913252457396056,6.4345,,1.6977376242035913,,4.066118812101796,,Uncertain,,Destabilizing,,0.5470199826963409,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,neutral,,-0.4245,1.0422,-22.2096,-5.80054592106197,0.8615191977464012,Pathogenic,0.9989,pathogenic,-4.484,available,https://doi.org/10.1101/2022.10.22.513328 +V143I,NP_000537:p.Val143Ile,,,,,saturation_mutlist,,,,,,,,-0.72774,0.0001115894317626917,,0.043395364587034975,,-0.34217231770648254,,Neutral,Neutral,,Neutral,0.1542582768376688,,0.16866058893234645,0.23872,,0.03775427087188587,,0.13823713543594293,,Neutral,,Neutral,,0.1935367143834054,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,neutral,,-0.0808,1.0422,-0.7173,-1.95319441454293,9.14274242289026e-05,Benign,0.1019,benign,-3.112,available,https://doi.org/10.1101/2022.10.22.513328 +V143K,NP_000537:p.Val143Lys,,,,,saturation_mutlist,,,,,,,,4.86304,3.115291748046875,,4.606576532620658,,4.7348082663103295,,Destabilizing,Destabilizing,,Destabilizing,0.32077793437924745,,0.4573051759505161,4.41523,,3.111544883132551,,3.763387441566276,,Destabilizing,,Destabilizing,,1.1432463440871727,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,neutral,,-0.4178,1.0422,-22.2096,-7.13843299043174,0.8694876056189005,Pathogenic,0.998,pathogenic,-4.695,available,https://doi.org/10.1101/2022.10.22.513328 +V143L,NP_000537:p.Val143Leu,"hg19,17:g.7578503C>A, hg19,17:g.7578503C>G, hg38,17:g.7675185C>A, hg38,17:g.7675185C>G",,,0.607,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2687704, 185729","Uncertain significance, Uncertain significance","0, 2",,,,,-0.36613,0.9196978569030761,0.8752833333333333,0.3176835714221807,0.2545766666666667,-0.024223214288909667,Neutral,Neutral,Neutral,Neutral,Neutral,0.31376348615720395,0.31840456365378234,0.1436522101012046,-0.218,1.3931966666666666,-0.036718924271209076,0.5875983333333333,-0.12735946213560453,Neutral,Neutral,Neutral,Neutral,0.6160304338982685,0.286408759324496,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,neutral,,-0.1775,1.0422,-6.9218,-2.09599099504191,0.123077284755386,Benign,0.5804,pathogenic,-3.398,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V143M,NP_000537:p.Val143Met,"hg19,17:g.7578503C>T, hg19,17:g.7675185C>T, hg38,17:g.7675185C>T",,,0.659,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142657,Pathogenic/Likely pathogenic,2,,,,,-0.2137,1.7176611042022705,1.4595266666666664,1.1695953355025852,0.6229133333333332,0.4779476677512926,Neutral,Neutral,Uncertain,Neutral,Neutral,0.3565573442768506,0.23447492294249483,0.13447484613744662,-0.54202,1.5282333333333333,0.6325878300814792,0.4931066666666667,0.04528391504073964,Neutral,Neutral,Neutral,Neutral,0.8915712520538607,0.25695488816544576,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,neutral,,-0.1968,1.0422,-8.9217,-2.51110586768785,0.2056673421361044,Benign,0.6458,pathogenic,-3.594,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V143N,NP_000537:p.Val143Asn,,,,,saturation_mutlist,,,,,,,,2.75159,3.3210294246673584,,2.3580250989219285,,2.554807549460964,,Uncertain,Destabilizing,,Uncertain,0.28870527563114695,,0.10782765773045212,1.77748,,2.17961300172906,,1.97854650086453,,Uncertain,,Neutral,,0.17013296198098005,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,uncertain,,-0.4094,1.0422,-22.2096,-7.13843299043174,0.8623320274808599,Pathogenic,0.9975,pathogenic,-4.567,available,https://doi.org/10.1101/2022.10.22.513328 +V143P,NP_000537:p.Val143Pro,,,,,saturation_mutlist,,,,,,,,6.9142,2.9109199333190916,,6.264125831737395,,6.589162915868698,,Destabilizing,Destabilizing,,Destabilizing,0.20868957532031018,,0.4191200390425743,3.93087,,6.617402881644043,,5.274136440822022,,Destabilizing,,Destabilizing,,0.33604260212608145,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,uncertain,,-0.4593,1.0422,-22.2096,-7.13843299043174,0.8700024669657285,Pathogenic,0.9976,pathogenic,-4.549,available,https://doi.org/10.1101/2022.10.22.513328 +V143Q,NP_000537:p.Val143Gln,,,,,saturation_mutlist,,,,,,,,3.14202,3.267083177566528,,2.436925341977174,,2.7894726709885873,,Uncertain,Destabilizing,,Uncertain,0.29672844137469184,,0.11311077598516289,2.20278,,1.9950538311032648,,2.0989169155516327,,Uncertain,,Uncertain,,0.23024520614750912,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,uncertain,,-0.3894,1.0422,-22.2096,-7.13843299043174,0.869880225197027,Pathogenic,0.9952,pathogenic,-4.478,available,https://doi.org/10.1101/2022.10.22.513328 +V143R,NP_000537:p.Val143Arg,,,,,saturation_mutlist,,,,,,,,7.78814,3.192344388961792,,3.5131771856925167,,5.650658592846258,,Destabilizing,Destabilizing,,Destabilizing,0.3413300453455788,,0.5455908131486188,6.32924,,2.0806583242490224,,4.204949162124511,,Uncertain,,Destabilizing,,0.9949074741532651,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,neutral,,-0.4388,1.0422,-22.2096,-7.13843299043174,0.8636938516303572,Pathogenic,0.9952,pathogenic,-4.548,available,https://doi.org/10.1101/2022.10.22.513328 +V143S,NP_000537:p.Val143Ser,,,,,saturation_mutlist,,,,,,,,3.90256,3.1435156440734864,,3.4480066284096402,,3.67528331420482,,Destabilizing,Destabilizing,,Destabilizing,0.27364848473905845,,0.25584989837827066,1.24612,,3.0251445473801923,,2.135632273690096,,Uncertain,,Uncertain,,0.41571273545307175,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,uncertain,,-0.3586,1.0422,-22.2096,-6.58221124789451,0.86703187301884,Pathogenic,0.9884,pathogenic,-4.43,available,https://doi.org/10.1101/2022.10.22.513328 +V143T,NP_000537:p.Val143Thr,,,,,saturation_mutlist,,,,,,,,1.95157,2.4017799949645995,,1.9656634011965262,,1.958616700598263,,Neutral,Destabilizing,,Neutral,0.19286095918704993,,0.1252187436966163,1.18841,,1.953531166174347,,1.5709705830871736,,Neutral,,Neutral,,0.17667250182015956,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,uncertain,,-0.274,1.0422,-22.2096,-6.58221124789451,0.8702844570409342,Pathogenic,0.9674,pathogenic,-4.193,available,https://doi.org/10.1101/2022.10.22.513328 +V143W,NP_000537:p.Val143Trp,,,,,saturation_mutlist,,,,,,,,9.79259,2.2524181604385376,,2.6022801421284965,,6.197435071064248,,Uncertain,Destabilizing,,Destabilizing,0.4694316913751892,,0.49086509255016464,11.42385,,0.7656762611682657,,6.094763130584132,,Uncertain,,Destabilizing,,1.2265159471665643,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,neutral,,-0.3726,1.0422,-22.2096,-5.80054592106197,0.8570448113633149,Pathogenic,0.9981,pathogenic,-4.573,available,https://doi.org/10.1101/2022.10.22.513328 +V143Y,NP_000537:p.Val143Tyr,,,,,saturation_mutlist,,,,,,,,5.64857,2.317739362716675,,2.478023664930044,,4.0632968324650225,,Uncertain,Destabilizing,,Destabilizing,0.4794196171086425,,0.28775803372424874,6.31643,,1.0444612549425634,,3.680445627471282,,Uncertain,,Destabilizing,,1.0983835885219715,0.405,0.73,3.615,2.884,,True,0.405,,neutral,neutral,neutral,,True,3.615,,neutral,neutral,neutral,neutral,,-0.3755,1.0422,-22.2096,-5.80054592106197,0.8500562584249854,Pathogenic,0.9934,pathogenic,-4.455,available,https://doi.org/10.1101/2022.10.22.513328 +Q144A,NP_000537:p.Gln144Ala,,,,,saturation_mutlist,,,,,,,,0.4431,0.6112229335308075,,0.6198476652494032,,0.5314738326247016,,Neutral,Neutral,,Neutral,0.3181151887694621,,0.2076290195528853,0.00797,,0.5639732243977168,,0.2859716121988584,,Neutral,,Neutral,,0.08531135198609609,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.2207,0.8595,-22.2125,-5.47584171679879,0.4485586435951262,Uncertain,0.6137,pathogenic,-3.871,available,https://doi.org/10.1101/2022.10.22.513328 +Q144C,NP_000537:p.Gln144Cys,,,,,saturation_mutlist,,,,,,,,0.35754,-0.06634608030319213,,0.9551309906395279,,0.656335495319764,,Neutral,Neutral,,Neutral,0.34152964401162605,,0.28409840683780013,0.1203,,1.249612571912577,,0.6849562859562885,,Neutral,,Neutral,,0.08979246654782645,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.2669,0.8595,-22.2125,-5.98492240284396,0.7848878441158132,Pathogenic,0.8954,pathogenic,-4.186,available,https://doi.org/10.1101/2022.10.22.513328 +Q144D,NP_000537:p.Gln144Asp,,,,,saturation_mutlist,,,,,,,,1.13845,1.7912906980514527,,1.2076576793595482,,1.173053839679774,,Neutral,Uncertain,,Neutral,0.509030541541058,,0.31742149956641286,0.50287,,0.8914615258299662,,0.6971657629149831,,Neutral,,Neutral,,0.13344117097117214,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.2251,0.8595,-6.1174,-2.26007412279668,0.0245010837691705,Benign,0.8812,pathogenic,-3.757,available,https://doi.org/10.1101/2022.10.22.513328 +Q144E,NP_000537:p.Gln144Glu,,,,,saturation_mutlist,,,,,,,,0.38226,0.7404696798324585,,0.9909772290203329,,0.6866186145101665,,Neutral,Neutral,,Neutral,0.27673436775857746,,0.3696358635611998,0.17367,,0.4763430122286973,,0.32500650611434867,,Neutral,,Neutral,,0.05583989795605377,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.1308,0.8595,-3.6029,-2.21335131323574,0.0002972095025136,Benign,0.1697,benign,-3.423,available,https://doi.org/10.1101/2022.10.22.513328 +Q144F,NP_000537:p.Gln144Phe,,,,,saturation_mutlist,,,,,,,,0.53229,0.18504468679428102,,-0.25798107364828776,,0.13715446317585614,,Neutral,Neutral,,Neutral,0.502013113127848,,0.24805952352269925,-0.96077,,-0.6346836816329479,,-0.7977268408164739,,Neutral,,Neutral,,0.22316718152112527,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.2749,0.8595,-22.2125,-5.80797337508587,0.8261174098147788,Pathogenic,0.9385,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328 +Q144G,NP_000537:p.Gln144Gly,,,,,saturation_mutlist,,,,,,,,1.67619,1.7858007049560547,,2.2543328955285458,,1.965261447764273,,Uncertain,Uncertain,,Neutral,0.35264455440520337,,0.42269224249494364,0.30991,,1.7272167921704007,,1.0185633960852003,,Neutral,,Neutral,,0.2260495287787402,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.2154,0.8595,-7.3398,-4.12015796705344,0.0169859823897434,Benign,0.7243,pathogenic,-3.822,available,https://doi.org/10.1101/2022.10.22.513328 +Q144H,NP_000537:p.Gln144His,"hg19,17:g.7578498C>A, hg19,17:g.7578498C>G, hg19,17:g.7675180C>A, hg38,17:g.7675180C>A, hg38,17:g.7675180C>G",,,0.708,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376648,Uncertain significance,1,,,Tier I - Strong,1,1.79401,0.6358018517494202,1.3323133333333332,0.39288931523632226,1.5631616666666668,1.0934496576181612,Neutral,Neutral,Neutral,Neutral,Neutral,0.35295837466638663,0.39179717153422916,0.3485925233557143,0.33629,2.5162166666666668,-0.02840535075988064,1.4262533333333334,0.15394232462005966,Uncertain,Neutral,Neutral,Neutral,2.287196253878437,0.13067671810893308,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.1458,0.8595,-7.3398,-3.77890391248845,0.0130463691698117,Benign,0.628,pathogenic,-3.513,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q144I,NP_000537:p.Gln144Ile,,,,,saturation_mutlist,,,,,,,,-0.28489,-0.11562230110168457,,-0.29248196534927345,,-0.28868598267463674,,Neutral,Neutral,,Neutral,0.5482973910590438,,0.2664051671002596,0.18366,,-0.3201770902471858,,-0.06825854512359292,,Neutral,,Neutral,,0.3431582875867568,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.2563,0.8595,-22.2125,-5.43354396044127,0.7763431997302048,Pathogenic,0.7989,pathogenic,-4.158,available,https://doi.org/10.1101/2022.10.22.513328 +Q144K,NP_000537:p.Gln144Lys,"hg19,17:g.7578500G>T, hg38,17:g.7675180_7675182delinsTTT, hg38,17:g.7675182G>T",,,0.763,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.2887,0.5890760660171509,1.2459166666666668,1.1085414872897812,0.4786083333333334,0.4099207436448906,Neutral,Neutral,Neutral,Neutral,Neutral,0.20263733669142686,0.3828689986869602,0.48626207024271295,-0.69894,2.774713333333333,0.490905348916477,1.0378866666666666,-0.10401732554176149,Uncertain,Neutral,Neutral,Neutral,2.398015876640983,0.05153543640000813,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.186,0.8595,-8.9247,-3.95325504913402,0.0718912139524061,Benign,0.335,benign,-3.602,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q144L,NP_000537:p.Gln144Leu,"hg19,17:g.7578499T>A, hg38,17:g.7675181T>A",,,0.764,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376647,Uncertain significance,3,,,,,-1.03555,0.3495530819892883,-0.7132666666666667,-0.6530388692551138,-0.8744083333333333,-0.8442944346275569,Neutral,Neutral,Neutral,Neutral,Neutral,0.4050198913438205,0.35180190300161196,0.13754473540371545,-0.89178,0.0787966666666667,-0.7182869179276788,-0.40649166666666664,-0.8050334589638395,Neutral,Neutral,Neutral,Neutral,1.1919812482119376,0.2612674253527857,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.1541,0.8595,-5.4654,-3.41436173687567,3.806050357246926e-05,Benign,0.344,ambiguous,-3.501,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q144M,NP_000537:p.Gln144Met,,,,,saturation_mutlist,,,,,,,,-1.00313,0.04006380319595337,,-0.14015484755744137,,-0.5716424237787208,,Neutral,Neutral,,Neutral,0.2779059071863867,,0.20668617829833347,-0.63842,,-0.16443049685800679,,-0.4014252484290034,,Neutral,,Neutral,,0.14445260931624937,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.2106,0.8595,-22.2125,-4.81881838143923,0.172650180305833,Benign,0.6092,pathogenic,-3.99,available,https://doi.org/10.1101/2022.10.22.513328 +Q144N,NP_000537:p.Gln144Asn,,,,,saturation_mutlist,,,,,,,,0.73114,1.3377632236480712,,0.5360322616217092,,0.6335861308108546,,Neutral,Uncertain,,Neutral,0.35336089761069844,,0.2554731313770197,0.09179,,0.5689951132798224,,0.33039255663991124,,Neutral,,Neutral,,0.08825714443408111,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.2363,0.8595,-22.2125,-3.49462640305761,0.3237152411138149,Uncertain,0.6816,pathogenic,-3.779,available,https://doi.org/10.1101/2022.10.22.513328 +Q144P,NP_000537:p.Gln144Pro,"hg19,17:g.7578498_7578499delinsCC, hg19,17:g.7578498_7578499delinsGG, hg19,17:g.7578499T>G, hg19,17:g.7675181T>G, hg38,17:g.7675181T>G",,,0.801,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",186594,Conflicting classifications of pathogenicity,1,,,,,1.21667,2.7601092767715456,3.3785733333333337,4.262563512650652,2.2976216666666667,2.7396167563253258,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,0.7627137010064994,1.8637296347974466,1.6006434356680572,1.13599,5.4705200000000005,2.397444650142901,3.303255,1.7667173250714505,Uncertain,Uncertain,Destabilizing,Neutral,0.7233602019740926,0.5507371764277134,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.3943,0.8595,-22.2125,-6.98438276993221,0.8401005732634821,Pathogenic,0.9497,pathogenic,-4.194,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q144R,NP_000537:p.Gln144Arg,"hg19,17:g.7578499T>C, hg38,17:g.7675181T>C",,,0.751,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2080519,Uncertain significance,2,,,,,-0.08262,0.7972820544242859,0.8569133333333334,0.47957681156240345,0.3871466666666667,0.19847840578120174,Neutral,Neutral,Neutral,Neutral,Neutral,0.24012829524391893,0.11680838278517894,0.3945089464507877,-0.1899,2.1248333333333336,0.0677164046191993,0.9674666666666668,-0.06109179769040036,Uncertain,Neutral,Neutral,Neutral,1.6715537388775616,0.14132734666977745,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.1846,0.8595,-8.9247,-4.06059577501546,0.0341927398105603,Benign,0.3028,benign,-3.554,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q144S,NP_000537:p.Gln144Ser,,,,,saturation_mutlist,,,,,,,,1.29815,0.6360795497894287,,1.3349765006425816,,1.3165632503212907,,Neutral,Neutral,,Neutral,0.38201764283611517,,0.23395083008525203,0.80319,,0.9237955911179383,,0.8634927955589691,,Neutral,,Neutral,,0.05522222163383825,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.1713,0.8595,-8.9247,-5.53088336738831,0.2756069615069493,Benign,0.6153,pathogenic,-3.73,available,https://doi.org/10.1101/2022.10.22.513328 +Q144T,NP_000537:p.Gln144Thr,,,,,saturation_mutlist,,,,,,,,1.82209,0.6140223968029023,,0.7660462699221356,,1.2940681349610679,,Neutral,Neutral,,Neutral,0.4233720703763279,,0.3121998496167767,1.55269,,0.5554169760370488,,1.0540534880185244,,Neutral,,Neutral,,0.17176639104542415,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.249,0.8595,-22.2125,-5.61368540392061,0.6134612442818825,Uncertain,0.5895,pathogenic,-3.847,available,https://doi.org/10.1101/2022.10.22.513328 +Q144V,NP_000537:p.Gln144Val,,,,,saturation_mutlist,,,,,,,,-0.0707,-0.05263810157775879,,-0.03162014186289421,,-0.0511600709314471,,Neutral,Neutral,,Neutral,0.46706989016972067,,0.3745610238747156,0.32069,,-0.13251976116828432,,0.09408511941585783,,Neutral,,Neutral,,0.31638867204682825,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.2563,0.8595,-22.2125,-5.68478873430795,0.8628468816897723,Pathogenic,0.6377,pathogenic,-4.071,available,https://doi.org/10.1101/2022.10.22.513328 +Q144W,NP_000537:p.Gln144Trp,,,,,saturation_mutlist,,,,,,,,1.63759,0.6055494689941406,,-0.22540411402301527,,0.7060929429884925,,Neutral,Neutral,,Neutral,0.4978432484941447,,0.21207161869910834,-0.1416,,-0.8990401132837603,,-0.5203200566418802,,Neutral,,Neutral,,0.26454703877411107,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.2743,0.8595,-22.2125,-5.80797337508587,0.7773268836725387,Pathogenic,0.9178,pathogenic,-4.244,available,https://doi.org/10.1101/2022.10.22.513328 +Q144Y,NP_000537:p.Gln144Tyr,,,,,saturation_mutlist,,,,,,,,1.17965,0.4386735010147095,,0.19434738591696119,,0.6869986929584806,,Neutral,Neutral,,Neutral,0.5387625813938826,,0.32369491379342447,-0.84511,,-0.4879800807913559,,-0.666545040395678,,Neutral,,Neutral,,0.2771311748350402,25.66,6.386,34.45,11.833,,True,25.66,,neutral,neutral,neutral,,True,34.45,,neutral,neutral,neutral,uncertain,,-0.2094,0.8595,-8.9247,-5.33989406687137,0.6409621918004836,Uncertain,0.8611,pathogenic,-4.095,available,https://doi.org/10.1101/2022.10.22.513328 +L145A,NP_000537:p.Leu145Ala,,,,,saturation_mutlist,,,,,,,,4.06359,1.9266765546798705,,3.4556856267317726,,3.7596378133658863,,Destabilizing,Uncertain,,Destabilizing,0.19970394222414828,,0.11264488041581701,1.34109,,2.6949309332943763,,2.018010466647188,,Uncertain,,Uncertain,,0.280929462529526,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.2729,1.5915,-22.2125,-4.11494634629023,0.602466209859354,Uncertain,0.9049,pathogenic,-3.668,available,https://doi.org/10.1101/2022.10.22.513328 +L145C,NP_000537:p.Leu145Cys,,,,,saturation_mutlist,,,,,,,,3.29959,0.9966254377365112,,3.298860426264017,,3.2992252131320083,,Destabilizing,Neutral,,Destabilizing,0.16962474586794113,,0.16167338450438562,1.6293,,2.5954699802370027,,2.1123849901185014,,Uncertain,,Uncertain,,0.1921858697256415,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.2622,1.5915,-22.2125,-5.68189181564467,0.5671343599064492,Uncertain,0.8445,pathogenic,-3.916,available,https://doi.org/10.1101/2022.10.22.513328 +L145D,NP_000537:p.Leu145Asp,,,,,saturation_mutlist,,,,,,,,4.30354,3.0824675941467286,,4.385358336317016,,4.3444491681585085,,Destabilizing,Destabilizing,,Destabilizing,0.3106740766258807,,0.09772726431722198,3.96796,,3.6290024523997406,,3.79848122619987,,Destabilizing,,Destabilizing,,0.4319718195792391,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.3944,1.5915,-22.2125,-6.46205310741211,0.6007461132985379,Uncertain,0.9993,pathogenic,-4.395,available,https://doi.org/10.1101/2022.10.22.513328 +L145E,NP_000537:p.Leu145Glu,,,,,saturation_mutlist,,,,,,,,3.70287,2.8018591022491455,,3.9408346616476178,,3.821852330823809,,Destabilizing,Destabilizing,,Destabilizing,0.29261849285029085,,0.22451150816894336,3.4845,,3.315605931870158,,3.400052965935079,,Destabilizing,,Destabilizing,,0.3523937451733754,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.3625,1.5915,-22.2125,-6.46205310741211,0.6855090378534573,Pathogenic,0.9948,pathogenic,-4.27,available,https://doi.org/10.1101/2022.10.22.513328 +L145F,NP_000537:p.Leu145Phe,,,,,saturation_mutlist,,,,,,,,0.57344,0.601822419166565,,1.1325535427692712,,0.8529967713846356,,Neutral,Neutral,,Neutral,0.30245444593816073,,0.33081578557539615,4.22872,,0.7498709026929933,,2.4892954513464964,,Uncertain,,Uncertain,,0.6528954857184919,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.2064,1.5915,-22.2125,-3.55424145494716,0.0480485800956523,Benign,0.4941,ambiguous,-3.351,available,https://doi.org/10.1101/2022.10.22.513328 +L145G,NP_000537:p.Leu145Gly,,,,,saturation_mutlist,,,,,,,,5.06744,2.5716551876068117,,5.346149626236122,,5.206794813118061,,Destabilizing,Destabilizing,,Destabilizing,0.2249726223158971,,0.1670308856672336,1.91219,,4.626025071434119,,3.2691075357170596,,Uncertain,,Destabilizing,,0.5479520206545666,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.3478,1.5915,-22.2125,-6.46205310741211,0.7598256505962272,Pathogenic,0.9865,pathogenic,-4.157,available,https://doi.org/10.1101/2022.10.22.513328 +L145H,NP_000537:p.Leu145His,,,,,saturation_mutlist,,,,,,,,2.5627,2.3498283863067626,,2.5147835604968587,,2.5387417802484293,,Uncertain,Destabilizing,,Uncertain,0.27903751369929175,,0.2893322674918707,5.41482,,2.001757813879572,,3.708288906939786,,Uncertain,,Destabilizing,,0.44295846820503704,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.3153,1.5915,-22.2125,-4.66303097954973,0.4946614943882225,Uncertain,0.9861,pathogenic,-4.281,available,https://doi.org/10.1101/2022.10.22.513328 +L145I,NP_000537:p.Leu145Ile,,,,,saturation_mutlist,,,,,,,,1.0137,-0.3126317262649536,,1.1441527440809827,,1.0789263720404914,,Neutral,Neutral,,Neutral,0.27962043574598355,,0.10207856250369521,1.69142,,1.1034065658932573,,1.3974132829466286,,Neutral,,Neutral,,0.062326847041923455,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,uncertain,,-0.0374,1.5915,-0.7202,-1.68455958088278,1.280998235892722e-06,Benign,0.1191,benign,-2.908,available,https://doi.org/10.1101/2022.10.22.513328 +L145K,NP_000537:p.Leu145Lys,,,,,saturation_mutlist,,,,,,,,3.44887,2.44564914226532,,5.135400642813836,,4.292135321406918,,Destabilizing,Destabilizing,,Destabilizing,0.2754389683450441,,0.14890835058095261,3.6563,,4.041064360051268,,3.848682180025634,,Destabilizing,,Destabilizing,,0.26290816316908067,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,uncertain,,-0.3615,1.5915,-22.2125,-6.46205310741211,0.6447415176660134,Uncertain,0.9946,pathogenic,-4.267,available,https://doi.org/10.1101/2022.10.22.513328 +L145M,NP_000537:p.Leu145Met,"hg19,17:g.7578497G>T, hg38,17:g.7675179G>T",,,0.505,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.16542,0.7480208063125611,0.6261899999999999,1.4616858613796333,0.23038499999999995,0.6481329306898167,Neutral,Neutral,Neutral,Neutral,Neutral,0.14300236711031655,0.33610936979897876,0.3550201217063728,-0.21174,1.3137166666666669,1.0355168725960648,0.5509883333333334,0.4118884362980324,Neutral,Neutral,Neutral,Neutral,0.5003163832571902,0.26281154846278,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,uncertain,,-0.077,1.5915,-3.9248,-1.64445050242912,5.912657478302182e-05,Benign,0.2145,benign,-3.025,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L145N,NP_000537:p.Leu145Asn,,,,,saturation_mutlist,,,,,,,,3.63436,2.7520212173461913,,3.009265417140423,,3.321812708570212,,Destabilizing,Destabilizing,,Destabilizing,0.2623618632319431,,0.18553281120592904,2.99444,,2.3291970140635776,,2.661818507031789,,Uncertain,,Uncertain,,0.2701789344221757,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.3407,1.5915,-22.2125,-6.46205310741211,0.5817329726016456,Uncertain,0.9951,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328 +L145P,NP_000537:p.Leu145Pro,"hg19,17:g.7578496A>G, hg19,17:g.7675178A>G, hg38,17:g.7675178A>G",,0.0,0.818,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142050,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,5.32037,2.505885238647461,4.954763333333333,7.245123851962649,5.137566666666666,6.282746925981325,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.25463299286958085,0.8969575532258417,0.32836614588044033,4.79053,3.670633333333333,6.58691453378692,4.230581666666667,5.6887222668934605,Destabilizing,Destabilizing,Destabilizing,Destabilizing,1.0475202249863986,0.2255073673472493,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.2885,1.5915,-8.9247,-4.11807604586948,0.1509902756751129,Benign,0.9946,pathogenic,-4.03,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L145Q,NP_000537:p.Leu145Gln,"hg19,17:g.7578496A>T, hg19,17:g.7675178A>T, hg38,17:g.7675178A>T",,,0.846,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480760,Conflicting classifications of pathogenicity,1,,,,,3.19831,2.5797881412506105,2.3661000000000003,2.863124266299529,2.7822050000000003,3.0307171331497647,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,0.2739771349031204,0.5387632497365301,0.2004307340400894,2.8597,1.8384366666666667,2.4110217481676677,2.3490683333333333,2.635360874083834,Uncertain,Uncertain,Uncertain,Uncertain,0.3919443336609026,0.2817061506902958,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.2937,1.5915,-22.2125,-6.46205310741211,0.6961265374088593,Pathogenic,0.9799,pathogenic,-4.188,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L145R,NP_000537:p.Leu145Arg,"hg19,17:g.7578495_7578496delinsAC, hg19,17:g.7578496A>C, hg19,17:g.7675177_7675178delinsAC, hg19,17:g.7675178A>C, hg38,17:g.7675177_7675178delinsAC, hg38,17:g.7675178A>C",,,0.845,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1027110,Uncertain significance,1,,,,,4.64517,2.4533749866485595,5.379476666666666,4.105744606026154,5.012323333333333,4.375457303013077,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.2599868242656077,0.2616152264087256,0.25732391725967485,4.94679,4.44592,2.98766345987493,4.6963550000000005,3.9672267299374653,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.41800896792612785,0.331494584037021,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.2853,1.5915,-8.9247,-6.46205310741211,0.0354268228068004,Benign,0.9863,pathogenic,-3.964,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L145S,NP_000537:p.Leu145Ser,,,,,saturation_mutlist,,,,,,,,4.7197,2.4396604442596437,,4.262356489407002,,4.4910282447035,,Destabilizing,Destabilizing,,Destabilizing,0.2666941385574759,,0.10267359246754644,2.46213,,3.536264595825005,,2.9991972979125023,,Uncertain,,Uncertain,,0.35638225341423174,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.3033,1.5915,-22.2125,-5.68189181564467,0.4704830036412578,Uncertain,0.9872,pathogenic,-4.13,available,https://doi.org/10.1101/2022.10.22.513328 +L145T,NP_000537:p.Leu145Thr,,,,,saturation_mutlist,,,,,,,,3.72946,1.973359799385071,,3.1836731811810277,,3.456566590590514,,Destabilizing,Uncertain,,Destabilizing,0.2642853266098043,,0.07860018502065025,2.42376,,2.6569026102668603,,2.54033130513343,,Uncertain,,Uncertain,,0.10685983505975147,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.2082,1.5915,-8.9247,-4.10483296448931,0.3989900369135243,Uncertain,0.9443,pathogenic,-3.857,available,https://doi.org/10.1101/2022.10.22.513328 +L145V,NP_000537:p.Leu145Val,"hg19,17:g.7578497G>C, hg38,17:g.7675179G>C",,,0.462,"COSMIC,ClinVar,saturation_mutlist",2774652,Conflicting classifications of pathogenicity,1,,,,,2.30112,0.2523801231384277,1.5572566666666665,1.596503354083425,1.9291883333333333,1.9488116770417125,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.23949403208951148,0.4203450471801576,0.12226817779029214,1.28916,1.01406,1.3754623087773525,1.15161,1.3323111543886763,Neutral,Neutral,Neutral,Neutral,0.46335788637581926,0.18379457755280137,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.0848,1.5915,-2.9024,-0.436000769096075,9.085797244172356e-07,Benign,0.1076,benign,-2.912,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L145W,NP_000537:p.Leu145Trp,,,,,saturation_mutlist,,,,,,,,5.54339,1.2072578382492065,,2.7695023165663373,,4.156446158283169,,Uncertain,Uncertain,,Destabilizing,0.27549232466464857,,0.37093142830191606,13.96738,,1.6624647728888646,,7.814922386444432,,Uncertain,,Destabilizing,,0.5846015279767901,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.3055,1.5915,-22.2125,-4.66303097954973,0.7512209210830842,Pathogenic,0.9454,pathogenic,-4.201,available,https://doi.org/10.1101/2022.10.22.513328 +L145Y,NP_000537:p.Leu145Tyr,,,,,saturation_mutlist,,,,,,,,1.85747,1.2144772100448609,,2.300701401740033,,2.0790857008700163,,Uncertain,Uncertain,,Uncertain,0.2724355306393888,,0.4255499992973596,7.35502,,1.5979445790255449,,4.476482289512772,,Uncertain,,Destabilizing,,0.6302193452741965,0.585,0.766,1.34,1.235,,False,0.585,,neutral,neutral,neutral,,False,1.34,,neutral,neutral,neutral,neutral,,-0.2984,1.5915,-22.2125,-3.81897848775477,0.0532419531893655,Benign,0.9558,pathogenic,-3.866,available,https://doi.org/10.1101/2022.10.22.513328 +W146A,NP_000537:p.Trp146Ala,,,,,saturation_mutlist,,,,,,,,1.07514,1.3944412398338317,,2.5454998109650155,,1.8103199054825079,,Uncertain,Uncertain,,Neutral,0.40499476977275395,,0.4406482294995491,0.71622,,2.0098359872501286,,1.3630279936250642,,Uncertain,,Neutral,,0.10481970482482353,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.3301,1.8527,-7.3368,-2.33091563655778,0.0151140715084037,Benign,0.5144,ambiguous,-3.24,available,https://doi.org/10.1101/2022.10.22.513328 +W146C,NP_000537:p.Trp146Cys,"hg19,17:g.7578492C>A, hg19,17:g.7578492C>G, hg38,17:g.7675174C>A, hg38,17:g.7675174C>G",,,0.629,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","1740219, 824855","Uncertain significance, Uncertain significance","1, 2",,,,,0.86757,-0.3081779479980469,2.4445566666666667,2.9489623300320793,1.6560633333333334,1.9082661650160397,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.3968110296438855,0.17936508585068126,0.4217034086832824,0.41616,2.269503333333333,2.318640155867667,1.3428316666666666,1.3674000779338336,Uncertain,Uncertain,Neutral,Neutral,0.3034044738555374,0.1080872353714411,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.3418,1.8527,-22.2096,-4.39907503912101,0.1421786878392424,Benign,0.6342,pathogenic,-3.606,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +W146D,NP_000537:p.Trp146Asp,,,,,saturation_mutlist,,,,,,,,1.64052,2.2279481506347656,,2.8268962047792647,,2.2337081023896324,,Uncertain,Destabilizing,,Uncertain,0.5387436592344084,,0.28303710239759833,1.88168,,2.203517208712508,,2.042598604356254,,Uncertain,,Uncertain,,0.297764468021756,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.4303,1.8527,-22.2096,-4.31205841423562,0.2443854002501679,Benign,0.8742,pathogenic,-3.664,available,https://doi.org/10.1101/2022.10.22.513328 +W146E,NP_000537:p.Trp146Glu,,,,,saturation_mutlist,,,,,,,,0.84278,1.5444199633598328,,2.3893533174880512,,1.6160666587440256,,Uncertain,Uncertain,,Neutral,0.44073168581482236,,0.19364569655180752,0.84599,,2.0287898426181745,,1.4373899213090873,,Uncertain,,Neutral,,0.1996186376720771,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.3688,1.8527,-6.3369,-2.51043412235874,0.0031625471499654,Benign,0.7421,pathogenic,-3.298,available,https://doi.org/10.1101/2022.10.22.513328 +W146F,NP_000537:p.Trp146Phe,,,,,saturation_mutlist,,,,,,,,-0.26658,0.12329361915588377,,0.7749591292804504,,0.25418956464022524,,Neutral,Neutral,,Neutral,0.10287900247966573,,0.06196493977902978,-0.16609,,0.6770589918548828,,0.25548449592744144,,Neutral,,Neutral,,0.09419395705015335,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.1908,1.8527,-8.9217,-1.69430611884554,0.0062870663276241,Benign,0.2585,benign,-3.327,available,https://doi.org/10.1101/2022.10.22.513328 +W146G,NP_000537:p.Trp146Gly,"hg19,17:g.7578494A>C, hg38,17:g.7675176A>C",,,0.536,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",186587,Uncertain significance,3,,,,,1.84513,1.9577249383926392,3.6602033333333335,3.8592776000871716,2.752666666666667,2.852203800043586,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.4659847935313172,0.3435853074403632,0.3380360677970381,1.34397,3.6212000000000004,3.0891644319709286,2.4825850000000003,2.2165672159854646,Uncertain,Uncertain,Uncertain,Uncertain,0.7780587213486312,0.26233745193503194,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.3912,1.8527,-22.2096,-4.88435409899919,0.0244414092070777,Benign,0.5479,ambiguous,-3.628,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +W146H,NP_000537:p.Trp146His,,,,,saturation_mutlist,,,,,,,,1.05206,0.5602450799942017,,1.489840770125446,,1.270950385062723,,Neutral,Neutral,,Neutral,0.41418611569223374,,0.3225853482616563,0.80265,,1.2053480036341575,,1.0039990018170788,,Neutral,,Neutral,,0.04557491948803135,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.3943,1.8527,-22.2096,-1.73419688470807,2.4505945825635267e-05,Benign,0.5021,ambiguous,-3.182,available,https://doi.org/10.1101/2022.10.22.513328 +W146I,NP_000537:p.Trp146Ile,,,,,saturation_mutlist,,,,,,,,-0.47776,-0.40686546087265013,,1.1993548108526773,,0.36079740542633865,,Neutral,Neutral,,Neutral,0.6159483736515681,,0.1347318850957933,-0.49225,,1.2209205190897439,,0.3643352595448719,,Neutral,,Neutral,,0.3361937415185404,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.3189,1.8527,-7.9218,-2.3525230187613,0.0269628373788254,Benign,0.5628,ambiguous,-3.441,available,https://doi.org/10.1101/2022.10.22.513328 +W146K,NP_000537:p.Trp146Lys,,,,,saturation_mutlist,,,,,,,,0.35774,0.6918854117393494,,2.276012977070746,,1.316876488535373,,Uncertain,Neutral,,Neutral,0.5059177907257234,,0.3645786031032304,-0.09494,,1.7244855382672546,,0.8147727691336273,,Neutral,,Neutral,,0.03881760762100633,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.3521,1.8527,-0.7124,-1.02914875730179,2.477580449200688e-07,Benign,0.675,pathogenic,-2.973,available,https://doi.org/10.1101/2022.10.22.513328 +W146L,NP_000537:p.Trp146Leu,,,,,saturation_mutlist,,,,,,,,-0.46573,0.029378125667572016,1.1493200000000001,1.0813747491624437,0.34179500000000007,0.30782237458122186,Neutral,Neutral,Neutral,Neutral,Neutral,0.6268604806139154,0.27376664746945834,0.20928654919344292,-0.49644,1.424603333333333,0.8982298615271076,0.4640816666666665,0.2008949307635538,Neutral,Neutral,Neutral,Neutral,0.3694803390649569,0.2476837461052957,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.2574,1.8527,-3.3983,-0.453222983900895,5.442517842699088e-05,Benign,0.3508,ambiguous,-3.072,available,https://doi.org/10.1101/2022.10.22.513328 +W146M,NP_000537:p.Trp146Met,,,,,saturation_mutlist,,,,,,,,-0.02351,0.17399165391921997,,1.5922606410647395,,0.7843753205323698,,Neutral,Neutral,,Neutral,0.4806699332729504,,0.18839112212339099,-0.31638,,1.2372186057060335,,0.46041930285301674,,Neutral,,Neutral,,0.17479067568513723,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.2926,1.8527,-7.9218,-1.86333475052515,0.0043266556808526,Benign,0.514,ambiguous,-3.42,available,https://doi.org/10.1101/2022.10.22.513328 +W146N,NP_000537:p.Trp146Asn,,,,,saturation_mutlist,,,,,,,,1.23095,1.0668710219860076,,2.355440753234989,,1.7931953766174944,,Uncertain,Uncertain,,Neutral,0.6034787972493642,,0.2224292497449291,0.97472,,1.6752225076522915,,1.3249712538261458,,Neutral,,Neutral,,0.1051795575410212,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.4385,1.8527,-22.2096,-4.57329976438315,0.0881462176403514,Benign,0.805,pathogenic,-3.474,available,https://doi.org/10.1101/2022.10.22.513328 +W146P,NP_000537:p.Trp146Pro,,,,,saturation_mutlist,,,,,,,,3.34757,2.5453908824920655,,5.635700446240051,,4.491635223120026,,Destabilizing,Destabilizing,,Destabilizing,0.47977967716385916,,0.5115916130979734,3.7536,,5.216161506445892,,4.484880753222946,,Destabilizing,,Destabilizing,,0.8062124596808857,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.4767,1.8527,-22.2096,-5.68979558297274,0.3400819381345366,Uncertain,0.9937,pathogenic,-3.884,available,https://doi.org/10.1101/2022.10.22.513328 +W146Q,NP_000537:p.Trp146Gln,,,,,saturation_mutlist,,,,,,,,0.62337,0.882989741563797,,2.3574884924759636,,1.4904292462379818,,Uncertain,Neutral,,Neutral,0.44924105076948534,,0.24926143320650132,0.33944,,1.7738082098559218,,1.056624104927961,,Neutral,,Neutral,,0.07701110627350764,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.3513,1.8527,-6.9218,-2.48562344942259,0.0012831561340812,Benign,0.5876,pathogenic,-3.136,available,https://doi.org/10.1101/2022.10.22.513328 +W146R,NP_000537:p.Trp146Arg,"hg38,17:g.7675176A>G, hg38,17:g.7675176A>T",,,0.464,"COSMIC,saturation_mutlist",,,,,,,,0.51326,0.694124345779419,1.6068033333333334,1.7352293424150045,1.0600316666666667,1.1242446712075023,Neutral,Neutral,Neutral,Neutral,Neutral,0.5010624165803422,0.20902256613953327,0.373962752482394,0.21409,1.9691599999999998,1.2318616481006412,1.0916249999999998,0.7229758240503206,Neutral,Neutral,Neutral,Neutral,0.38037798893556746,0.05088339680966366,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.3031,1.8527,-5.2214,-1.04959842261786,1.2106439667860752e-05,Benign,0.5671,pathogenic,-2.98,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +W146S,NP_000537:p.Trp146Ser,"hg19,17:g.7578493C>G, hg19,17:g.7675175C>G, hg38,17:g.7675175C>G",,,0.521,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.62254,1.206399998664856,2.7087299999999996,3.0711539012799545,2.165635,2.346846950639977,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.403487047214876,0.28620302339423326,0.4629746407455429,0.94686,3.1185966666666665,2.244847449530186,2.032728333333333,1.595853724765093,Uncertain,Uncertain,Uncertain,Neutral,0.3242706466655422,0.18766751854195346,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.4041,1.8527,-22.2096,-3.56781936813426,0.002140907001527,Benign,0.3925,ambiguous,-3.262,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +W146T,NP_000537:p.Trp146Thr,,,,,saturation_mutlist,,,,,,,,1.33281,1.0250706028938295,,2.454032808199839,,1.8934214040999193,,Uncertain,Uncertain,,Neutral,0.38938076818174816,,0.40264922817731874,0.68969,,1.9623334490852955,,1.3260117245426477,,Neutral,,Neutral,,0.21831409383671407,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.3718,1.8527,-7.3368,-2.18213104316455,0.0001103002188972,Benign,0.4427,ambiguous,-3.099,available,https://doi.org/10.1101/2022.10.22.513328 +W146V,NP_000537:p.Trp146Val,,,,,saturation_mutlist,,,,,,,,0.25728,-0.19596675157546997,,1.4454633485032051,,0.8513716742516025,,Neutral,Neutral,,Neutral,0.5760144698416401,,0.18761606569145747,-0.11166,,1.3615955724892856,,0.6249677862446428,,Neutral,,Neutral,,0.24935795998245372,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.2944,1.8527,-4.7519,-1.76708133306087,1.990571766854424e-05,Benign,0.4597,ambiguous,-3.12,available,https://doi.org/10.1101/2022.10.22.513328 +W146Y,NP_000537:p.Trp146Tyr,,,,,saturation_mutlist,,,,,,,,-0.42899,0.1321257448196411,,0.9814174994617181,,0.27621374973085905,,Neutral,Neutral,,Neutral,0.06740857824467603,,0.05990319662497449,-0.04295,,0.8003745383014716,,0.3787122691507358,,Neutral,,Neutral,,0.034230908690428455,34.597,4.982,47.395,9.486,,False,34.597,,neutral,neutral,neutral,,False,47.395,,neutral,neutral,neutral,uncertain,,-0.2387,1.8527,-8.9217,-1.52105448558601,0.1925520307473832,Benign,0.3846,ambiguous,-3.372,available,https://doi.org/10.1101/2022.10.22.513328 +V147A,NP_000537:p.Val147Ala,"hg19,17:g.7578490A>G, hg38,17:g.7675172A>G",,,0.812,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",842812,Uncertain significance,2,,,,,1.85701,1.2397593140602112,1.69195,2.1067408272138173,1.77448,1.9818754136069088,Neutral,Uncertain,Uncertain,Neutral,Neutral,0.30758464707599226,0.411485590837233,0.32507008321338327,-3.33894,1.8260766666666666,2.1198669139775745,-0.7564316666666667,-0.6095365430112127,Uncertain,Uncertain,Neutral,Neutral,0.323030877815453,0.3019083424433389,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,neutral,,-0.3045,0.5036,-22.2096,-4.29904961719234,0.1554233101588092,Benign,0.5938,pathogenic,-3.678,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V147C,NP_000537:p.Val147Cys,,,,,saturation_mutlist,,,,,,,,1.12495,0.7067752885818481,,1.9741398318905021,,1.549544915945251,,Neutral,Neutral,,Neutral,0.19963664566447079,,0.23185318766785284,-2.05634,,2.162971823554395,,0.05331591177719752,,Uncertain,,Neutral,,0.16563655978853037,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,neutral,,-0.3324,0.5036,-22.2096,-3.83219042712051,0.4191857340062551,Uncertain,0.8732,pathogenic,-3.691,available,https://doi.org/10.1101/2022.10.22.513328 +V147D,NP_000537:p.Val147Asp,"hg19,17:g.7578490A>T, hg19,17:g.7675172A>T, hg38,17:g.7675172A>T",,,0.896,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1351017,Conflicting classifications of pathogenicity,1,,,,,2.75581,2.6831548595428467,2.6242633333333334,3.430609467850514,2.690036666666667,3.093209733925257,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,0.28988442740910414,0.6641193433077789,0.10820483247541583,2.88637,3.980046666666667,3.5537015074692655,3.4332083333333334,3.2200357537346327,Uncertain,Uncertain,Destabilizing,Destabilizing,1.2959085696744026,0.5056227650488532,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,neutral,,-0.4711,0.5036,-22.2096,-6.60001975419788,0.8378373379244817,Pathogenic,0.9858,pathogenic,-4.354,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V147E,NP_000537:p.Val147Glu,"hg38,17:g.7675171_7675172inv",,,,"COSMIC,saturation_mutlist",,,,,,,,1.87051,2.6282481384277343,2.6783433333333337,3.149826401047722,2.274426666666667,2.510168200523861,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,0.3411337452326987,1.2030289503951639,0.20423373806062375,5.44294,4.881403333333333,3.7397401393372274,5.162171666666667,4.591340069668614,Destabilizing,Destabilizing,Destabilizing,Destabilizing,1.5465375679095401,0.7109806524808417,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,uncertain,,-0.4284,0.5036,-22.2096,-6.60001975419788,0.8526580998730378,Pathogenic,0.9668,pathogenic,-4.306,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V147F,NP_000537:p.Val147Phe,"hg38,17:g.7675173C>A",,,0.747,"COSMIC,saturation_mutlist",,,,,,,,0.68429,1.063595404624939,0.5263,0.43987034431482447,0.6052949999999999,0.5620801721574122,Neutral,Neutral,Uncertain,Neutral,Neutral,0.45266537296827813,0.6416815020449528,0.4499369465256093,12.07297,3.857483333333333,1.8438743147559709,7.965226666666666,6.958422157377985,Destabilizing,Uncertain,Destabilizing,Destabilizing,3.2326030188104173,1.4420738320039723,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,uncertain,,-0.3057,0.5036,-7.3368,-1.76724972552787,0.6789632646602263,Uncertain,0.6895,pathogenic,-3.739,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V147G,NP_000537:p.Val147Gly,"hg19,17:g.7578490A>C, hg19,17:g.7675172A>C, hg38,17:g.7675172A>C",,,0.895,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3602769,Pathogenic/Likely pathogenic,2,,,,,2.92752,2.229746446609497,3.5849200000000003,3.9303407872204175,3.25622,3.4289303936102087,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.27625117024887075,0.5347752724899185,0.42021462127348164,-3.7068,4.306916666666667,3.926905159260143,0.30005833333333354,0.11005257963007153,Uncertain,Uncertain,Neutral,Neutral,0.7190510568952823,0.087821388350541,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,neutral,,-0.4303,0.5036,-22.2096,-6.60001975419788,0.8137922732719153,Pathogenic,0.6169,pathogenic,-4.106,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V147H,NP_000537:p.Val147His,,,,,saturation_mutlist,,,,,,,,2.03916,2.1662914180755615,,1.4982110826546007,,1.7686855413273004,,Uncertain,Destabilizing,,Neutral,0.2986976473498688,,0.06188749402154232,10.29129,,2.716930048906828,,6.504110024453414,,Uncertain,,Destabilizing,,1.2482546195756874,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,uncertain,,-0.4741,0.5036,-22.2096,-5.32163014695496,0.8036522917447922,Pathogenic,0.9883,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328 +V147I,NP_000537:p.Val147Ile,"hg19,17:g.7578491C>T, hg38,17:g.7675173C>T",,,0.549,"COSMIC,ClinVar,saturation_mutlist",528255,Uncertain significance,1,,,,,0.29346,0.5257226753234864,1.2196166666666668,0.7043538728609088,0.7565383333333334,0.49890693643045436,Neutral,Neutral,Neutral,Neutral,Neutral,0.2618589448104561,0.4582583940917565,0.35120024061275723,2.0972,0.6648499999999999,1.2212554480188922,1.381025,1.6592277240094462,Uncertain,Uncertain,Neutral,Neutral,1.0649752851905374,0.12524929075172453,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,uncertain,,-0.1671,0.5036,-7.9218,-2.44074556637347,0.3450712461101911,Uncertain,0.2039,benign,-3.514,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V147K,NP_000537:p.Val147Lys,,,,,saturation_mutlist,,,,,,,,2.3159,2.329533939361572,,3.307561687461584,,2.8117308437307917,,Uncertain,Destabilizing,,Uncertain,0.33137725805268875,,0.1660581952634918,6.67751,,4.88112045919828,,5.77931522959914,,Destabilizing,,Destabilizing,,1.482555000579982,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,uncertain,,-0.4673,0.5036,-22.2096,-6.60001975419788,0.8612447946939559,Pathogenic,0.9786,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +V147L,NP_000537:p.Val147Leu,,,,,saturation_mutlist,,,,,,,,-0.71836,0.9710064649581909,,0.6571500724741877,,-0.030604963762906168,,Neutral,Neutral,,Neutral,0.437228369285644,,0.27599257368626984,2.24385,,1.388883607639423,,1.8163668038197116,,Uncertain,,Neutral,,0.44439820996953827,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,uncertain,,-0.2152,0.5036,-4.5999,-2.1594368414436,0.000619043819819,Benign,0.4268,ambiguous,-3.189,available,https://doi.org/10.1101/2022.10.22.513328 +V147M,NP_000537:p.Val147Met,,,,,saturation_mutlist,,,,,,,,-0.92595,1.1028699803352355,,1.139705021141437,,0.10687751057071848,,Neutral,Uncertain,,Neutral,0.4117670887410329,,0.26553029443310305,1.82833,,1.8971848013890693,,1.8627574006945347,,Neutral,,Neutral,,0.7372943056528505,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,uncertain,,-0.2332,0.5036,-6.3369,-2.08304348806462,0.0004735383653707,Benign,0.3729,ambiguous,-3.383,available,https://doi.org/10.1101/2022.10.22.513328 +V147N,NP_000537:p.Val147Asn,,,,,saturation_mutlist,,,,,,,,1.77506,2.3782444763183594,,2.0082883607833666,,1.8916741803916834,,Uncertain,Destabilizing,,Neutral,0.3274800251988582,,0.218407834289847,1.44996,,2.2762193788833813,,1.8630896894416906,,Uncertain,,Neutral,,0.524354067528293,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,neutral,,-0.4589,0.5036,-22.2096,-6.60001975419788,0.8002469178034609,Pathogenic,0.9533,pathogenic,-4.287,available,https://doi.org/10.1101/2022.10.22.513328 +V147P,NP_000537:p.Val147Pro,,,,,saturation_mutlist,,,,,,,,2.74161,2.350509843826294,,5.742348615185655,,4.241979307592827,,Uncertain,Destabilizing,,Destabilizing,0.2748510958005444,,0.7010800416676588,-1.47705,,5.821978947940209,,2.1724644739701042,,Uncertain,,Uncertain,,0.3289763490396593,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,neutral,,-0.5088,0.5036,-22.2096,-6.60001975419788,0.8112710505848709,Pathogenic,0.9883,pathogenic,-4.11,available,https://doi.org/10.1101/2022.10.22.513328 +V147Q,NP_000537:p.Val147Gln,,,,,saturation_mutlist,,,,,,,,1.50386,2.1586640071868897,,2.121745537403036,,1.812802768701518,,Uncertain,Destabilizing,,Neutral,0.3666527125212778,,0.3400334476465543,3.94426,,2.805121582438892,,3.3746907912194457,,Uncertain,,Destabilizing,,0.684313049367053,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,uncertain,,-0.439,0.5036,-22.2096,-6.60001975419788,0.8273378144396569,Pathogenic,0.9648,pathogenic,-4.104,available,https://doi.org/10.1101/2022.10.22.513328 +V147R,NP_000537:p.Val147Arg,,,,,saturation_mutlist,,,,,,,,3.51257,2.2759248876571654,,2.282233733503011,,2.8974018667515056,,Uncertain,Destabilizing,,Uncertain,0.3148035081810106,,0.1849967550081798,10.48643,,3.8228288572898816,,7.154629428644941,,Destabilizing,,Destabilizing,,1.6267437340466042,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,uncertain,,-0.4884,0.5036,-22.2096,-6.60001975419788,0.8539653538854353,Pathogenic,0.9647,pathogenic,-4.26,available,https://doi.org/10.1101/2022.10.22.513328 +V147S,NP_000537:p.Val147Ser,,,,,saturation_mutlist,,,,,,,,2.20278,1.595462818145752,,3.0252308697643144,,2.6140054348821575,,Uncertain,Uncertain,,Uncertain,0.37111336774870474,,0.3250346732981999,-1.95173,,2.935236377117049,,0.49175318855852446,,Uncertain,,Neutral,,0.13585685929372868,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,neutral,,-0.4081,0.5036,-22.2096,-3.95248303533272,0.496367070951342,Uncertain,0.8128,pathogenic,-3.888,available,https://doi.org/10.1101/2022.10.22.513328 +V147T,NP_000537:p.Val147Thr,,,,,saturation_mutlist,,,,,,,,1.16166,0.8687254953384399,,1.8707220837950926,,1.5161910418975464,,Neutral,Neutral,,Neutral,0.35882012122307166,,0.30108995040097514,-0.67852,,2.1147276625672093,,0.7181038312836047,,Uncertain,,Neutral,,0.14296635730668883,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,neutral,,-0.2455,0.5036,-6.9218,-2.61569002291227,0.002320868353933,Benign,0.3624,ambiguous,-3.366,available,https://doi.org/10.1101/2022.10.22.513328 +V147W,NP_000537:p.Val147Trp,,,,,saturation_mutlist,,,,,,,,3.88141,1.8841350269317627,,1.2333479053619605,,2.5573789526809803,,Uncertain,Uncertain,,Uncertain,0.48712725840125837,,0.16636029585440568,21.6221,,3.158393321568804,,12.390246660784403,,Destabilizing,,Destabilizing,,2.0834661153772536,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,uncertain,,-0.4222,0.5036,-22.2096,-4.98433149263082,0.2327838000471104,Benign,0.9882,pathogenic,-3.96,available,https://doi.org/10.1101/2022.10.22.513328 +V147Y,NP_000537:p.Val147Tyr,,,,,saturation_mutlist,,,,,,,,2.09651,1.6299936771392822,,1.0732318912493677,,1.584870945624684,,Uncertain,Uncertain,,Neutral,0.43848204993773165,,0.32234898475321555,14.87174,,2.6686916582239157,,8.770215829111958,,Uncertain,,Destabilizing,,1.810156698585059,12.69,7.979,0.295,0.551,,True,12.69,,neutral,neutral,neutral,,True,0.295,,neutral,neutral,neutral,uncertain,,-0.4251,0.5036,-22.2096,-5.10837726795603,0.6503537677826763,Uncertain,0.9724,pathogenic,-3.99,available,https://doi.org/10.1101/2022.10.22.513328 +D148A,NP_000537:p.Asp148Ala,"hg19,17:g.7578487T>G, hg38,17:g.7675169T>G",,,0.404,"ClinVar,saturation_mutlist",485032,Conflicting classifications of pathogenicity,1,,,,,0.1493,0.2285824680328369,1.3670066666666667,0.17180646721719448,0.7581533333333333,0.16055323360859725,Neutral,Neutral,Neutral,Neutral,Neutral,0.1773379000450186,0.17355310932263807,0.13762501426109588,-0.09842,0.9469366666666668,0.7282117788079864,0.4242583333333334,0.3148958894039932,Neutral,Neutral,Neutral,Neutral,0.4987564299557673,0.27880202096166395,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.0152,2.6864,-5.3369,-0.334270581908593,6.617034226686461e-10,Benign,0.1061,benign,-2.956,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D148C,NP_000537:p.Asp148Cys,,,,,saturation_mutlist,,,,,,,,0.30136,-0.01278294324874879,,0.7950860980574271,,0.5482230490287135,,Neutral,Neutral,,Neutral,0.1151052835155644,,0.11483035282294393,0.19921,,1.2536026912051765,,0.7264063456025882,,Neutral,,Neutral,,0.10475434358579243,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.075,2.6864,-8.9217,-1.20584410401836,0.0008610289024357,Benign,0.339,benign,-3.332,available,https://doi.org/10.1101/2022.10.22.513328 +D148E,NP_000537:p.Asp148Glu,"hg19,17:g.7578486A>C, hg19,17:g.7578486A>T, hg38,17:g.7675168A>C, hg38,17:g.7675168A>T",,,0.289,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1478891,Uncertain significance,1,,,,,0.06593,0.13989129781723023,0.9803866666666666,-0.0346522899313815,0.5231583333333333,0.01563885503430925,Neutral,Neutral,Neutral,Neutral,Neutral,0.09392269111546052,0.05901548064326473,0.079317092608055,-0.16555,0.12335666666666667,0.4587352828893762,-0.021096666666666666,0.1465926414446881,Neutral,Neutral,Neutral,Neutral,0.6263561564229164,0.47158652667099915,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,0.0392,2.6864,-5.4624,-0.292296604278704,1.588519523802838e-08,Benign,0.1156,benign,-2.87,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D148F,NP_000537:p.Asp148Phe,,,,,saturation_mutlist,,,,,,,,0.21255,0.4376565670967102,,-0.17371040928627401,,0.019419795356862987,,Neutral,Neutral,,Neutral,0.12816166934595602,,0.16824412905691685,-0.43351,,-0.18673918462304395,,-0.310124592311522,,Neutral,,Neutral,,0.33058236835967986,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.2015,2.6864,-22.2096,-3.47422679014876,0.005093223166417,Benign,0.4713,ambiguous,-3.587,available,https://doi.org/10.1101/2022.10.22.513328 +D148G,NP_000537:p.Asp148Gly,"hg19,17:g.7578487T>C, hg19,17:g.7675169T>C, hg38,17:g.7675169T>C",,,0.467,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.19605,0.7875899493694305,2.1615633333333335,0.8485084650147746,1.1788066666666668,0.5222792325073873,Uncertain,Neutral,Neutral,Neutral,Neutral,0.21636574797767202,0.20323097817234684,0.06618758507441487,-0.30797,1.1410433333333334,1.2435151131047961,0.41653666666666667,0.467772556552398,Neutral,Neutral,Neutral,Neutral,0.7205270445691512,0.26795624563151355,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.0294,2.6864,-5.9218,-1.80105349013127,2.1571931350358533e-08,Benign,0.1079,benign,-3.002,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D148H,NP_000537:p.Asp148His,"hg19,17:g.7578488C>G, hg19,17:g.7675170C>G, hg38,17:g.7675170C>G",,,0.482,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.44052,0.33849080562591555,1.6168933333333333,-0.2085376185202549,1.0287066666666667,0.11599119073987256,Neutral,Neutral,Neutral,Neutral,Neutral,0.15443183680975767,0.1929397834098043,0.05507076497095118,0.14267,-0.003739999999999991,0.020854136552040364,0.069465,0.08176206827602017,Neutral,Neutral,Neutral,Neutral,0.289515034612482,0.12146976033640301,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.1107,2.6864,-22.2096,-2.84148321697135,0.0001859009476552,Benign,0.1571,benign,-3.238,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D148I,NP_000537:p.Asp148Ile,,,,,saturation_mutlist,,,,,,,,0.31257,0.30159304857254027,,-0.19743664244483886,,0.05756667877758058,,Neutral,Neutral,,Neutral,0.14181657503075884,,0.18141731520704452,0.3045,,0.3165810046842498,,0.31054050234212494,,Neutral,,Neutral,,0.26010392365080787,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.1259,2.6864,-8.9217,-1.2262573792571,0.0001583770400177,Benign,0.2932,benign,-3.392,available,https://doi.org/10.1101/2022.10.22.513328 +D148K,NP_000537:p.Asp148Lys,,,,,saturation_mutlist,,,,,,,,0.01401,0.35470679998397825,,-0.040396571228182465,,-0.013193285614091232,,Neutral,Neutral,,Neutral,0.1728037821607985,,0.028439320969076323,-0.26594,,0.467073423142657,,0.10056671157132849,,Neutral,,Neutral,,0.34361257319545335,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.0992,2.6864,-7.9218,-1.60860474942785,9.758280601214073e-08,Benign,0.2374,benign,-3.133,available,https://doi.org/10.1101/2022.10.22.513328 +D148L,NP_000537:p.Asp148Leu,,,,,saturation_mutlist,,,,,,,,0.05367,0.19379265308380128,,-0.47963802778993836,,-0.21298401389496918,,Neutral,Neutral,,Neutral,0.11148582824813902,,0.15508155208670593,-0.40185,,-0.1526690125765588,,-0.2772595062882794,,Neutral,,Neutral,,0.167381359153994,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.0889,2.6864,-2.9218,-1.27920062530759,1.0836121455665938e-05,Benign,0.2614,benign,-3.168,available,https://doi.org/10.1101/2022.10.22.513328 +D148M,NP_000537:p.Asp148Met,,,,,saturation_mutlist,,,,,,,,0.01305,0.2711688661575317,,-0.07615796184124111,,-0.031553980920620554,,Neutral,Neutral,,Neutral,0.1373538354544575,,0.14086123379568577,-0.52552,,0.18104601137947926,,-0.17223699431026035,,Neutral,,Neutral,,0.14691395024223997,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.0217,2.6864,-1.7519,-1.28055057566239,0.0001163911311489,Benign,0.4263,ambiguous,-3.306,available,https://doi.org/10.1101/2022.10.22.513328 +D148N,NP_000537:p.Asp148Asn,"hg19,17:g.7578488C>T, hg19,17:g.7675170C>T, hg38,17:g.7675170C>T",,,0.277,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",568069,Uncertain significance,1,,,,,-0.16914,-0.00342049837112427,1.1777766666666667,-0.043681644320441436,0.5043183333333333,-0.10641082216022073,Neutral,Neutral,Neutral,Neutral,Neutral,0.16418532826137344,0.15460682915777757,0.021660768329251505,0.06165,-0.10124666666666665,0.45953753197738073,-0.019798333333333324,0.2605937659886904,Neutral,Neutral,Neutral,Neutral,0.31182352448495965,0.07641038963099857,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,0.0222,2.6864,-4.5295,-0.336671300426911,1.632867440977589e-09,Benign,0.0719,benign,-2.869,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D148P,NP_000537:p.Asp148Pro,,,,,saturation_mutlist,,,,,,,,2.09954,2.508330211639404,,4.251869490317538,,3.175704745158769,,Uncertain,Destabilizing,,Destabilizing,0.2817122595359934,,0.8498007960083959,3.44662,,3.2478504363064062,,3.347235218153203,,Destabilizing,,Destabilizing,,1.9890561063391894,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.2383,2.6864,-22.2096,-3.91190764584153,5.193254412519911e-05,Benign,0.6418,pathogenic,-3.351,available,https://doi.org/10.1101/2022.10.22.513328 +D148Q,NP_000537:p.Asp148Gln,,,,,saturation_mutlist,,,,,,,,0.06841,0.2177506136894226,,0.17735313759902183,,0.12288156879951091,,Neutral,Neutral,,Neutral,0.1335956532805348,,0.10217781217416713,-0.26823,,0.553655105098325,,0.1427125525491625,,Neutral,,Neutral,,0.2433338133215326,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.0605,2.6864,-8.9217,-1.28091288379219,3.536137760973022e-06,Benign,0.1844,benign,-3.088,available,https://doi.org/10.1101/2022.10.22.513328 +D148R,NP_000537:p.Asp148Arg,,,,,saturation_mutlist,,,,,,,,0.06583,0.20879860162734987,,-0.26010393611033295,,-0.09713696805516647,,Neutral,Neutral,,Neutral,0.18024141374038846,,0.06075384903712302,-0.18237,,0.22966491775475364,,0.02364745887737682,,Neutral,,Neutral,,0.24119000757110493,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.1251,2.6864,-6.9218,-0.680094235195205,1.1249936849555423e-06,Benign,0.2281,benign,-3.162,available,https://doi.org/10.1101/2022.10.22.513328 +D148S,NP_000537:p.Asp148Ser,,,,,saturation_mutlist,,,,,,,,0.10528,0.0756062078475952,,0.28320213717349507,,0.19424106858674753,,Neutral,Neutral,,Neutral,0.23963495446610766,,0.028109841955205654,0.12083,,0.804529733196977,,0.4626798665984885,,Neutral,,Neutral,,0.41453406922372527,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.0038,2.6864,-1.8344,0.0247349799681672,5.0862238466257574e-14,Benign,0.0713,benign,-2.779,available,https://doi.org/10.1101/2022.10.22.513328 +D148T,NP_000537:p.Asp148Thr,,,,,saturation_mutlist,,,,,,,,0.46064,0.02546379327774046,,0.09108582130534375,,0.2758629106526719,,Neutral,Neutral,,Neutral,0.24647770219666368,,0.10623350747304683,0.5209,,0.7896299065243849,,0.6552649532621925,,Neutral,,Neutral,,0.4344397576351356,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.0469,2.6864,-4.3983,-0.0770725391737,3.2718042238375694e-13,Benign,0.1162,benign,-2.852,available,https://doi.org/10.1101/2022.10.22.513328 +D148V,NP_000537:p.Asp148Val,"hg19,17:g.7578487T>A, hg38,17:g.7675169T>A",,,0.551,"COSMIC,ClinVar,saturation_mutlist",2687708,Uncertain significance,0,,,,,0.48751,0.31183648347854614,1.3314033333333335,-0.022955777509579934,0.9094566666666668,0.23227711124521003,Neutral,Neutral,Neutral,Neutral,Neutral,0.148818611065388,0.3863714418650645,0.10628375900361457,0.4795,1.9450100000000001,0.43420789226544554,1.212255,0.4568539461327228,Neutral,Neutral,Neutral,Neutral,1.9575929817508033,0.23298456738141904,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.1484,2.6864,-22.2096,-1.36574732863833,1.7556134673725282e-05,Benign,0.1965,benign,-3.218,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D148W,NP_000537:p.Asp148Trp,,,,,saturation_mutlist,,,,,,,,0.39926,0.6074911975860595,,-0.6117523104684875,,-0.10624615523424377,,Neutral,Neutral,,Neutral,0.13598523976475457,,0.1756850320994041,-0.19415,,-0.5418796311037322,,-0.3680148155518661,,Neutral,,Neutral,,0.1744908938637227,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.1819,2.6864,-22.2096,-3.47422679014876,0.0069127030284249,Benign,0.7607,pathogenic,-3.7,available,https://doi.org/10.1101/2022.10.22.513328 +D148Y,NP_000537:p.Asp148Tyr,"hg19,17:g.7578488C>A, hg38,17:g.7675170C>A",,3.9790859244e-06,0.531,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428863,Conflicting classifications of pathogenicity,1,,,,,0.22632,0.5221109795570373,1.4683666666666666,-0.12304282985176328,0.8473433333333333,0.05163858507411836,Neutral,Neutral,Neutral,Neutral,Neutral,0.15035260694028743,0.12328413180760754,0.13758307252797122,-0.26725,-0.3454633333333333,-0.09168436165071088,-0.3063566666666666,-0.17946718082535543,Neutral,Neutral,Neutral,Neutral,0.842335221327524,0.24877292556375039,74.959,6.239,69.145,16.194,,True,74.959,,neutral,neutral,neutral,,True,69.145,,neutral,neutral,neutral,uncertain,,-0.1463,2.6864,-22.2096,-3.47422679014876,0.0298127752522772,Benign,0.208,benign,-3.641,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S149A,NP_000537:p.Ser149Ala,,,,,saturation_mutlist,,,,,,,,0.34596,0.1792666113376617,,-0.19106502177131143,,0.07744748911434428,,Neutral,Neutral,,Neutral,0.19386425213793365,,0.05980627656594291,0.42968,,0.2712044185243021,,0.3504422092621511,,Neutral,,Neutral,,0.13410450130260948,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.003,2.0855,-5.4654,-0.441886299497982,0.0001505148817471,Benign,0.0651,benign,-3.138,available,https://doi.org/10.1101/2022.10.22.513328 +S149C,NP_000537:p.Ser149Cys,"hg19,17:g.7578484G>C, hg38,17:g.7675166G>C",,,0.482,"ClinVar,saturation_mutlist",3328163,Uncertain significance,1,,,,,0.27842,-0.1861910939216614,,0.4711319379322054,,0.3747759689661027,,Neutral,Neutral,,Neutral,0.15578007382310038,,0.068427781448727,0.5849,,0.8530362039942121,,0.718968101997106,,Neutral,,Neutral,,0.11840103811607598,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.1389,2.0855,-22.2125,-2.47381113141007,0.2357008286893609,Benign,0.0758,benign,-3.57,available,https://doi.org/10.1101/2022.10.22.513328 +S149D,NP_000537:p.Ser149Asp,,,,,saturation_mutlist,,,,,,,,0.37207,1.0993502616882325,,0.2105420138372125,,0.29130600691860625,,Neutral,Uncertain,,Neutral,0.19435896350392456,,0.15001566304506797,-0.07511,,0.0457994379655652,,-0.014655281017217397,,Neutral,,Neutral,,0.13779859989750168,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.1112,2.0855,-7.3398,-1.31671889963374,0.0635294872058832,Benign,0.2592,benign,-3.541,available,https://doi.org/10.1101/2022.10.22.513328 +S149E,NP_000537:p.Ser149Glu,,,,,saturation_mutlist,,,,,,,,0.13305,0.6509010171890259,,-0.16255012920199982,,-0.01475006460099991,,Neutral,Neutral,,Neutral,0.21920721165096402,,0.11261618036720046,0.60527,,0.025588301822693033,,0.3154291509113465,,Neutral,,Neutral,,0.046799494853808306,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.0844,2.0855,-7.3398,-2.46496811433743,0.0047011292292298,Benign,0.3048,benign,-3.427,available,https://doi.org/10.1101/2022.10.22.513328 +S149F,NP_000537:p.Ser149Phe,"hg19,17:g.7578484G>A, hg38,17:g.7675165_7675166delinsAA, hg38,17:g.7675166G>A",,,0.457,"COSMIC,ClinVar,saturation_mutlist",486559,Uncertain significance,2,,,,,-0.0598,0.1475665521621704,-0.22846,-0.7212448945427653,-0.14413,-0.39052244727138263,Neutral,Neutral,Neutral,Neutral,Neutral,0.2158111382930707,0.09434066072837664,0.1302394397488669,0.3823,1.69263,-0.27679673197027127,1.037465,0.05275163401486435,Neutral,Neutral,Neutral,Neutral,2.233739853922117,0.16969888932742047,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.0906,2.0855,-7.3398,-2.29251350000616,0.0174306977084863,Benign,0.1304,benign,-3.408,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S149G,NP_000537:p.Ser149Gly,,,,,saturation_mutlist,,,,,,,,0.74412,0.863496584892273,,0.7368827134000254,,0.7405013567000127,,Neutral,Neutral,,Neutral,0.11721726870889973,,0.10667123092891505,-0.5006,,0.5527719235616969,,0.026085961780848432,,Neutral,,Neutral,,0.3647243623735639,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,neutral,,-0.018,2.0855,-6.6029,-2.69038127217085,0.0005422564016362,Benign,0.0908,benign,-3.234,available,https://doi.org/10.1101/2022.10.22.513328 +S149H,NP_000537:p.Ser149His,,,,,saturation_mutlist,,,,,,,,0.37014,0.10049001455307006,,-0.4862574518991057,,-0.05805872594955283,,Neutral,Neutral,,Neutral,0.21880625124174718,,0.0949457906715868,0.45634,,-0.32636769604300897,,0.06498615197849553,,Neutral,,Neutral,,0.08649910515750266,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.0881,2.0855,-6.6029,-2.28467469963585,0.0001606034394828,Benign,0.195,benign,-3.26,available,https://doi.org/10.1101/2022.10.22.513328 +S149I,NP_000537:p.Ser149Ile,,,,,saturation_mutlist,,,,,,,,0.09746,-0.15691744089126586,,-0.7423645640013742,,-0.3224522820006871,,Neutral,Neutral,,Neutral,0.3469846430952161,,0.23924123374167355,1.35404,,0.33810122545393023,,0.846070612726965,,Neutral,,Neutral,,0.5022952965280117,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.1696,2.0855,-22.2125,-3.57240385221268,0.0543290273440125,Benign,0.1517,benign,-3.64,available,https://doi.org/10.1101/2022.10.22.513328 +S149K,NP_000537:p.Ser149Lys,,,,,saturation_mutlist,,,,,,,,-0.29789,-0.14153779506683348,,-0.3400957657474466,,-0.3189928828737233,,Neutral,Neutral,,Neutral,0.16084418978009085,,0.08085222638809939,0.19661,,-0.1441197366326563,,0.02624513168367186,,Neutral,,Neutral,,0.10159682556255253,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.0833,2.0855,-3.8374,-2.25649660515639,0.0003346668722222,Benign,0.3828,ambiguous,-3.246,available,https://doi.org/10.1101/2022.10.22.513328 +S149L,NP_000537:p.Ser149Leu,,,,,saturation_mutlist,,,,,,,,-0.09446,0.1913788914680481,,-0.8692787627595617,,-0.48186938137978086,,Neutral,Neutral,,Neutral,0.25180522053542076,,0.1063676313716616,0.54483,,-0.4011750180901143,,0.07182749095494287,,Neutral,,Neutral,,0.16404885084271836,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.09,2.0855,-7.3398,-1.20887317566972,0.0002326407701198,Benign,0.0907,benign,-3.29,available,https://doi.org/10.1101/2022.10.22.513328 +S149M,NP_000537:p.Ser149Met,,,,,saturation_mutlist,,,,,,,,-0.33118,0.07808329820632935,,-0.4112460739788017,,-0.37121303698940084,,Neutral,Neutral,,Neutral,0.18897920601832432,,0.12669349531593002,0.59024,,-0.04396881042194508,,0.27313559478902744,,Neutral,,Neutral,,0.12864630570631327,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.064,2.0855,-7.9247,-2.33079840305445,0.0670440033658271,Benign,0.1457,benign,-3.616,available,https://doi.org/10.1101/2022.10.22.513328 +S149N,NP_000537:p.Ser149Asn,,,,,saturation_mutlist,,,,,,,,0.38432,0.25229803800582884,,-0.011141623829892066,,0.18658918808505395,,Neutral,Neutral,,Neutral,0.2281938505682203,,0.07190451898866977,0.31765,,-0.09352803643195089,,0.11206098178402454,,Neutral,,Neutral,,0.1329871624575117,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.0311,2.0855,-6.6029,-2.17419214764211,0.0003529237507555,Benign,0.1281,benign,-3.171,available,https://doi.org/10.1101/2022.10.22.513328 +S149P,NP_000537:p.Ser149Pro,"hg19,17:g.7578485A>G, hg38,17:g.7675167A>G",,,0.558,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2679232,Uncertain significance,2,,,,,2.9562,2.1484002017974855,5.425623333333334,3.4228646572549537,4.190911666666667,3.189532328627477,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.36910769919183,0.2663373151141653,1.0726542654324493,1.53466,4.92608,3.680745624231379,3.2303699999999997,2.6077028121156896,Uncertain,Uncertain,Destabilizing,Uncertain,0.31332863780169634,1.4582507317247577,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,uncertain,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.2419,2.0855,-22.2125,-3.23974064391757,0.178062403996352,Benign,0.5992,pathogenic,-3.482,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S149Q,NP_000537:p.Ser149Gln,,,,,saturation_mutlist,,,,,,,,-0.02471,0.16920024156570432,,-0.07400893404868897,,-0.04935946702434448,,Neutral,Neutral,,Neutral,0.14872830624107902,,0.09048904769448855,0.35051,,0.17455063420888148,,0.26253031710444075,,Neutral,,Neutral,,0.11329901325512033,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.0507,2.0855,-6.6029,-2.16255306307816,0.0001592529843122,Benign,0.2758,benign,-3.198,available,https://doi.org/10.1101/2022.10.22.513328 +S149R,NP_000537:p.Ser149Arg,,,,,saturation_mutlist,,,,,,,,-0.44659,-0.3445818543434143,,-0.6617029097154004,,-0.5541464548577002,,Neutral,Neutral,,Neutral,0.16936086536614786,,0.04185056221451255,0.23984,,-0.3150261365443409,,-0.03759306827217046,,Neutral,,Neutral,,0.11741826748344164,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.0983,2.0855,-5.7549,-2.1182382503908,0.0001924324827332,Benign,0.3187,benign,-3.288,available,https://doi.org/10.1101/2022.10.22.513328 +S149T,NP_000537:p.Ser149Thr,"hg38,17:g.7675167A>T",,,0.327,"COSMIC,saturation_mutlist",,,,,,,,0.17539,-0.1594007444381714,-0.29807,-0.2000039276695185,-0.061340000000000006,-0.012306963834759252,Neutral,Neutral,Neutral,Neutral,Neutral,0.20711605819396345,0.21347150676378338,0.1400401829127467,0.90011,-0.46814,0.3985245869922706,0.21598499999999998,0.6493172934961353,Neutral,Neutral,Neutral,Neutral,0.5872986638840582,0.273260567427665,51.213,4.564,75.8,12.788,P,True,51.213,0.15,neutral,neutral,potentially_damaging,P,True,75.8,0.583,neutral,neutral,potentially_damaging,uncertain,,0.0298,2.0855,-0.8587,-1.28064812545963,0.0004273463182668,Benign,0.0641,benign,-3.08,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S149V,NP_000537:p.Ser149Val,,,,,saturation_mutlist,,,,,,,,0.25519,-0.2601910448074341,,-0.5548084012797293,,-0.14980920063986466,,Neutral,Neutral,,Neutral,0.28949145452652914,,0.20782365078443946,1.41508,,0.28566424705901666,,0.8503721235295083,,Neutral,,Neutral,,0.3976639866402862,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.0578,2.0855,-5.3398,-2.06093296271041,0.0002813740895691,Benign,0.1229,benign,-3.21,available,https://doi.org/10.1101/2022.10.22.513328 +S149W,NP_000537:p.Ser149Trp,,,,,saturation_mutlist,,,,,,,,0.19857,0.38722334265708924,,-1.106737625650843,,-0.4540838128254215,,Neutral,Neutral,,Neutral,0.3066098717174869,,0.11595549365941867,0.86839,,-0.6075649855094689,,0.13041250724526554,,Neutral,,Neutral,,0.2506396528293436,51.213,4.564,75.8,12.788,P,True,51.213,0.15,damaging,neutral,potentially_damaging,P,True,75.8,0.583,damaging,neutral,potentially_damaging,uncertain,,-0.1762,2.0855,-22.2125,-3.93529936534686,0.3687759200559155,Uncertain,0.27,benign,-3.946,available,https://doi.org/10.1101/2022.10.22.513328 +S149Y,NP_000537:p.Ser149Tyr,"hg19,17:g.7578484G>T, hg38,17:g.7675166G>T",,,0.448,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2754115,Uncertain significance,1,,,,,0.05518,0.17667904615402222,-0.4442166666666667,-0.633427937418746,-0.19451833333333335,-0.289123968709373,Neutral,Neutral,Neutral,Neutral,Neutral,0.29600937707747205,0.07077208599126886,0.10191882960066173,0.567,2.415646666666667,-0.24869631436987483,1.4913233333333333,0.15915184281506256,Uncertain,Neutral,Neutral,Neutral,2.877983265811129,0.16464593971656863,51.213,4.564,75.8,12.788,P,True,51.213,0.15,uncertain,neutral,potentially_damaging,P,True,75.8,0.583,uncertain,neutral,potentially_damaging,uncertain,,-0.1713,2.0855,-22.2125,-3.6432437730098,0.1688355168999101,Benign,0.1357,benign,-3.568,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T150A,NP_000537:p.Thr150Ala,"hg38,17:g.7675164T>C",,,0.333,"COSMIC,saturation_mutlist",,,,,,,,0.51467,0.43704067945480346,0.7905899999999999,0.43277501541421953,0.6526299999999999,0.4737225077071098,Neutral,Neutral,Neutral,Neutral,Neutral,0.1604217933854127,0.14937973378831101,0.3486252921765668,-1.35488,-0.39886666666666665,0.201113609147366,-0.8768733333333334,-0.576883195426317,Neutral,Neutral,Neutral,Neutral,0.4776229277950918,0.09915375172089406,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.04,2.0879,-4.4654,-0.0583395233845751,1.1272819687196609e-08,Benign,0.0591,benign,-2.8,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T150C,NP_000537:p.Thr150Cys,,,,,saturation_mutlist,,,,,,,,-0.10616,0.2092952847480774,,0.7530256184888073,,0.32343280924440365,,Neutral,Neutral,,Neutral,0.11240886919005141,,0.2756602539969444,-0.84812,,0.7091060645879984,,-0.06950696770600079,,Neutral,,Neutral,,0.0387808265220736,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.1664,2.0879,-22.2125,-2.3012366863889,0.0049915791095936,Benign,0.1784,benign,-3.305,available,https://doi.org/10.1101/2022.10.22.513328 +T150D,NP_000537:p.Thr150Asp,,,,,saturation_mutlist,,,,,,,,0.46574,0.5289824044704438,,0.62432802178743,,0.545034010893715,,Neutral,Neutral,,Neutral,0.28927516079559984,,0.4935876699214506,0.34013,,0.16954175104693323,,0.2548358755234666,,Neutral,,Neutral,,0.10978433566078333,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.163,2.0879,-5.9248,-1.44127999418459,6.484501307435367e-07,Benign,0.2075,benign,-3.126,available,https://doi.org/10.1101/2022.10.22.513328 +T150E,NP_000537:p.Thr150Glu,,,,,saturation_mutlist,,,,,,,,0.03469,0.5737488806247711,,0.3797051000065988,,0.2071975500032994,,Neutral,Neutral,,Neutral,0.3423693758186722,,0.4273404344868535,0.3595,,-0.027847512052425,,0.16582624397378748,,Neutral,,Neutral,,0.16232212875064264,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.1273,2.0879,-3.7549,-1.46975084596866,4.4576088901927806e-08,Benign,0.1734,benign,-3.027,available,https://doi.org/10.1101/2022.10.22.513328 +T150F,NP_000537:p.Thr150Phe,,,,,saturation_mutlist,,,,,,,,-0.74747,0.4124863874912262,,-0.6566837365572018,,-0.7020768682786009,,Neutral,Neutral,,Neutral,0.20565513978077757,,0.16969915409785785,1.64667,,-0.22245839424569916,,0.7121058028771504,,Neutral,,Neutral,,0.09487298868839322,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.2378,2.0879,-22.2125,-2.94300550062853,0.0053734573450688,Benign,0.14,benign,-3.423,available,https://doi.org/10.1101/2022.10.22.513328 +T150G,NP_000537:p.Thr150Gly,,,,,saturation_mutlist,,,,,,,,1.15225,1.1669819951057434,,1.5248793520952935,,1.3385646760476466,,Neutral,Uncertain,,Neutral,0.22844032074262116,,0.425614415335672,-1.5254,,0.8540357455258797,,-0.3356821272370602,,Neutral,,Neutral,,0.061332070006453396,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.1362,2.0879,-8.9247,-2.52309798408859,2.48702865458978e-05,Benign,0.1689,benign,-3.102,available,https://doi.org/10.1101/2022.10.22.513328 +T150H,NP_000537:p.Thr150His,,,,,saturation_mutlist,,,,,,,,0.19333,0.3918205463886261,,-0.17362703034626079,,0.009851484826869608,,Neutral,Neutral,,Neutral,0.22287434459526026,,0.29773209961114083,1.47543,,-0.2131984180502183,,0.6311157909748909,,Neutral,,Neutral,,0.06936905790921025,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.2181,2.0879,-22.2125,-3.26204842079165,0.0015876434830574,Benign,0.1355,benign,-3.274,available,https://doi.org/10.1101/2022.10.22.513328 +T150I,NP_000537:p.Thr150Ile,"hg19,17:g.7578481G>A, hg38,17:g.7675163G>A",,,0.381,"COSMIC,ClinVar,saturation_mutlist",1350373,Conflicting classifications of pathogenicity,1,,,,,-0.76649,0.04367400169372559,-0.41598666666666667,-0.772307997384153,-0.5912383333333333,-0.7693989986920765,Neutral,Neutral,Neutral,Neutral,Neutral,0.3262924930832093,0.3651078227349042,0.1946101442622231,0.74771,-0.026076666666666637,-0.1994563858954945,0.3608166666666667,0.27412680705225273,Neutral,Neutral,Neutral,Neutral,0.927507691875862,0.05816132781559544,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.1564,2.0879,-22.2125,-3.1252856324116,0.0029552703372262,Benign,0.0817,benign,-3.418,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T150K,NP_000537:p.Thr150Lys,"hg38,17:g.7675163G>T",,,0.394,"COSMIC,saturation_mutlist",,,,,,,,-0.36087,0.8733101511001586,0.8568033333333333,0.44241480697154206,0.2479666666666666,0.04077240348577102,Neutral,Neutral,Neutral,Neutral,Neutral,0.3146571421376385,0.2985947825323737,0.3925227478687328,-0.20618,-0.040929999999999994,-0.08124095566146423,-0.123555,-0.14371047783073213,Neutral,Neutral,Neutral,Neutral,0.20764436343581943,0.09873378657063046,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.1407,2.0879,-7.9247,-1.92414956095744,3.769194876056462e-05,Benign,0.1507,benign,-3.112,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T150L,NP_000537:p.Thr150Leu,,,,,saturation_mutlist,,,,,,,,-1.25622,0.07956254482269287,,-0.897387978728851,,-1.0768039893644255,,Neutral,Neutral,,Neutral,0.42824035483582773,,0.06933226402942812,-0.13924,,-0.3502572237817247,,-0.24474861189086233,,Neutral,,Neutral,,0.02831819367886263,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.1355,2.0879,-7.9247,-0.837289512398319,8.721763057193193e-08,Benign,0.0579,benign,-3.002,available,https://doi.org/10.1101/2022.10.22.513328 +T150M,NP_000537:p.Thr150Met,,,,,saturation_mutlist,,,,,,,,-1.34939,0.31617783308029174,,-0.5092474464726694,,-0.9293187232363347,,Neutral,Neutral,,Neutral,0.31079423390905686,,0.1048683674240434,-0.4706,,-0.014396022454877635,,-0.24249801122743883,,Neutral,,Neutral,,0.089261256412395,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.1024,2.0879,-7.9247,-1.81763674032839,8.166705578117588e-05,Benign,0.0712,benign,-3.186,available,https://doi.org/10.1101/2022.10.22.513328 +T150N,NP_000537:p.Thr150Asn,,,,,saturation_mutlist,,,,,,,,0.04992,0.6074509882926941,,0.29590699380967217,,0.1729134969048361,,Neutral,Neutral,,Neutral,0.23413605788977582,,0.300933069071306,-0.18074,,0.18041163015357164,,-0.00016418492321418343,,Neutral,,Neutral,,0.04881720246351923,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.0941,2.0879,-4.1699,-1.60949400738253,0.0003228007104106,Benign,0.0873,benign,-3.168,available,https://doi.org/10.1101/2022.10.22.513328 +T150P,NP_000537:p.Thr150Pro,,,,,saturation_mutlist,,,,,,,,-0.37586,0.2701170516014099,,0.9514021053918237,,0.28777105269591186,,Neutral,Neutral,,Neutral,0.3446705517588862,,0.4835699853684637,-0.47122,,1.2688118720810144,,0.3987959360405072,,Neutral,,Neutral,,0.702709401293151,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.1854,2.0879,-0.7549,-0.0596061249256362,1.4246130708016462e-16,Benign,0.0473,benign,-2.674,available,https://doi.org/10.1101/2022.10.22.513328 +T150Q,NP_000537:p.Thr150Gln,,,,,saturation_mutlist,,,,,,,,-0.31962,0.6271208727359772,,0.2708514291599906,,-0.024384285420004703,,Neutral,Neutral,,Neutral,0.23783225264838995,,0.23067114335734035,0.09206,,0.17399430762615312,,0.13302715381307656,,Neutral,,Neutral,,0.07601600727604359,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.1125,2.0879,-5.9248,-1.20236455542424,1.0653459022365548e-06,Benign,0.1288,benign,-2.974,available,https://doi.org/10.1101/2022.10.22.513328 +T150R,NP_000537:p.Thr150Arg,"hg38,17:g.7675163G>C",,,0.441,"COSMIC,saturation_mutlist",,,,,,,,-0.32598,0.8123119997978211,0.8501133333333333,-0.017204626187186472,0.26206666666666667,-0.17159231309359324,Neutral,Neutral,Neutral,Neutral,Neutral,0.2824582991355879,0.3118902606509041,0.27653386474448155,0.19453,0.061676666666666664,-0.22194279832039768,0.12810333333333335,-0.013706399160198834,Neutral,Neutral,Neutral,Neutral,0.25997287837174266,0.07968690814033778,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.2165,2.0879,-22.2125,-2.56508867935359,0.0006001931308391,Benign,0.123,benign,-3.143,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T150S,NP_000537:p.Thr150Ser,,,,,saturation_mutlist,,,,,,,,0.44928,0.29183591961860655,,0.6455808249147944,,0.5474304124573972,,Neutral,Neutral,,Neutral,0.19823842752822432,,0.3782525811141946,-0.8941,,0.2636368673335639,,-0.315231566333218,,Neutral,,Neutral,,0.06378669772317036,52.804,13.301,48.44,24.795,P,True,52.804,0.627,neutral,neutral,potentially_damaging,P,True,48.44,4.024,neutral,damaging,potentially_damaging,uncertain,,-0.0065,2.0879,-5.0179,-1.18291027179086,1.6273476702270094e-07,Benign,0.0791,benign,-2.846,available,https://doi.org/10.1101/2022.10.22.513328 +T150V,NP_000537:p.Thr150Val,,,,,saturation_mutlist,,,,,,,,-0.04186,0.08893138408660889,,-0.6203239572966673,,-0.3310919786483337,,Neutral,Neutral,,Neutral,0.2040934731223385,,0.21251337273758636,0.05912,,-0.12026708086475967,,-0.030573540432379833,,Neutral,,Neutral,,0.06129912459448692,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,damaging,potentially_damaging,uncertain,,-0.066,2.0879,-6.9248,-1.94571387094201,1.6237545491750614e-07,Benign,0.0733,benign,-3.015,available,https://doi.org/10.1101/2022.10.22.513328 +T150W,NP_000537:p.Thr150Trp,,,,,saturation_mutlist,,,,,,,,-0.38936,0.12738390922546386,,-0.8826339707240374,,-0.6359969853620187,,Neutral,Neutral,,Neutral,0.26019157327450365,,0.18631712996343994,2.94136,,-0.5365264118363733,,1.2024167940818133,,Uncertain,,Neutral,,0.06573114916463983,52.804,13.301,48.44,24.795,P,True,52.804,0.627,damaging,neutral,potentially_damaging,P,True,48.44,4.024,damaging,uncertain,potentially_damaging,uncertain,,-0.2307,2.0879,-22.2125,-3.461339694155,0.0037853430596953,Benign,0.3901,ambiguous,-3.545,available,https://doi.org/10.1101/2022.10.22.513328 +T150Y,NP_000537:p.Thr150Tyr,,,,,saturation_mutlist,,,,,,,,-0.43074,0.22563856720924377,,-0.422763121128024,,-0.426751560564012,,Neutral,Neutral,,Neutral,0.25051814054730925,,0.20057915864025022,2.44847,,-0.20659748877711062,,1.1209362556114446,,Uncertain,,Neutral,,0.07793857144146701,52.804,13.301,48.44,24.795,P,True,52.804,0.627,uncertain,neutral,potentially_damaging,P,True,48.44,4.024,uncertain,uncertain,potentially_damaging,uncertain,,-0.2392,2.0879,-22.2125,-3.461339694155,0.0024173161784223,Benign,0.1817,benign,-3.44,available,https://doi.org/10.1101/2022.10.22.513328 +P151A,NP_000537:p.Pro151Ala,"hg19,17:g.7578479G>C, hg19,17:g.7675161G>C, hg38,17:g.7675161G>C",,,0.889,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376641,Pathogenic,2,,,,,3.30549,1.4215346813201903,1.24297,0.17790807731196803,2.2742299999999998,1.7416990386559839,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.719148615173414,0.15794228397318646,0.24119294716237688,1.42414,-0.8606566666666667,0.2925793306989369,0.2817416666666666,0.8583596653494684,Neutral,Neutral,Neutral,Neutral,1.7019531136772115,0.5664219468893935,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.3057,0.2371,-22.2096,-4.63399215214883,0.3922748470932101,Uncertain,0.6047,pathogenic,-3.65,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151C,NP_000537:p.Pro151Cys,,,,,saturation_mutlist,,,,,,,,3.0271,0.9932581996917724,,0.6845691414412283,,1.855834570720614,,Uncertain,Neutral,,Neutral,0.6543777837766144,,0.2675129652153896,1.84149,,0.896912949266539,,1.3692014746332695,,Neutral,,Neutral,,0.4189043625796072,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,uncertain,,-0.3384,0.2371,-22.2096,-6.16363153915127,0.8549852279033611,Pathogenic,0.9338,pathogenic,-4.065,available,https://doi.org/10.1101/2022.10.22.513328 +P151D,NP_000537:p.Pro151Asp,,,,,saturation_mutlist,,,,,,,,5.10659,2.0829528522491456,,1.9748600723033392,,3.5407250361516693,,Uncertain,Destabilizing,,Destabilizing,0.4928787777884583,,0.059383984777201186,3.77264,,1.0564893994026294,,2.4145646997013146,,Uncertain,,Uncertain,,1.1075732388787858,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,uncertain,,-0.3643,0.2371,-22.2096,-6.04162002975824,0.5194523335672228,Uncertain,0.9991,pathogenic,-4.27,available,https://doi.org/10.1101/2022.10.22.513328 +P151E,NP_000537:p.Pro151Glu,,,,,saturation_mutlist,,,,,,,,3.17983,1.8291498470306395,,1.6787688908342224,,2.429299445417111,,Uncertain,Uncertain,,Uncertain,0.5238468200680736,,0.16779602349867614,3.29432,,0.9778083362080373,,2.1360641681040184,,Uncertain,,Uncertain,,1.1858720977657544,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.3481,0.2371,-22.2096,-6.63561000906772,0.6378211624082941,Uncertain,0.9961,pathogenic,-4.249,available,https://doi.org/10.1101/2022.10.22.513328 +P151F,NP_000537:p.Pro151Phe,"hg19,17:g.7578478_7578479delinsAA, hg38,17:g.7675160_7675161delinsAA",,,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",824960,Likely pathogenic,1,,,,,7.45064,0.7995189476013184,5.2619066666666665,-0.12716925256672654,6.356273333333333,3.6617353737166365,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,1.0927942912666284,1.4889484484098912,0.20041596863243294,3.87802,-0.9307266666666667,-0.4376279030332175,1.4736466666666665,1.7201960484833911,Uncertain,Uncertain,Neutral,Neutral,1.9649641000000202,0.119658274205367,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.3668,0.2371,-22.2096,-6.4931966516819,0.5886171425541176,Uncertain,0.9875,pathogenic,-4.129,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151G,NP_000537:p.Pro151Gly,,,,,saturation_mutlist,,,,,,,,5.03593,1.74890589594841,,2.13038711427861,,3.5831585571393045,,Uncertain,Uncertain,,Destabilizing,0.7018423022085469,,0.19965156361205735,0.80005,,1.6395238758210369,,1.2197869379105184,,Neutral,,Neutral,,0.6173021765933823,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.3201,0.2371,-22.2096,-7.06411280791238,0.6840883236950395,Pathogenic,0.9777,pathogenic,-4.08,available,https://doi.org/10.1101/2022.10.22.513328 +P151H,NP_000537:p.Pro151His,"hg19,17:g.7578477_7578478delinsAT, hg19,17:g.7578478G>T, hg19,17:g.7675160G>T, hg38,17:g.7675159_7675160delinsAT, hg38,17:g.7675160G>T",,,0.870,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376639,Uncertain significance,1,Likely oncogenic,1,Tier I - Strong,1,8.38567,1.884842357635498,4.783446666666666,0.7852647169649595,6.584558333333333,4.58546735848248,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.7105071160336599,1.9354363799469674,0.1076754832279521,4.47946,0.74796,0.05408359967800258,2.61371,2.2667717998390016,Uncertain,Uncertain,Uncertain,Uncertain,3.9444964248431007,0.5146929326976789,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.2766,0.2371,-8.9217,-6.83338577080362,0.777237693318333,Pathogenic,0.992,pathogenic,-4.273,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151I,NP_000537:p.Pro151Ile,,,,,saturation_mutlist,,,,,,,,2.82139,1.3783760690689086,,0.08058177784621604,,1.450985888923108,,Uncertain,Uncertain,,Neutral,0.7951925590395666,,0.08634451618592966,3.83705,,-0.045895211653471955,,1.895577394173264,,Uncertain,,Neutral,,0.6061360047411828,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.2821,0.2371,-8.9217,-4.13924626261262,0.2755533318288037,Benign,0.733,pathogenic,-3.946,available,https://doi.org/10.1101/2022.10.22.513328 +P151K,NP_000537:p.Pro151Lys,,,,,saturation_mutlist,,,,,,,,6.00507,1.9455886554718018,,3.2982316158743465,,4.651650807937173,,Destabilizing,Uncertain,,Destabilizing,0.48258826800311805,,0.437306523953301,2.33278,,1.1619296809276236,,1.747354840463812,,Uncertain,,Neutral,,1.1423504350436773,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.3398,0.2371,-22.2096,-6.3532726475116,0.5063367787410941,Uncertain,0.9968,pathogenic,-4.22,available,https://doi.org/10.1101/2022.10.22.513328 +P151L,NP_000537:p.Pro151Leu,"hg19,17:g.7578478G>A, hg19,17:g.7675160G>A, hg38,17:g.7675159_7675160delinsAA, hg38,17:g.7675160G>A",,,0.771,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.77633,1.2523846173286437,2.7834466666666664,-0.13740606333917252,2.279888333333333,0.8194619683304137,Uncertain,Neutral,Uncertain,Uncertain,Neutral,0.7377319059281886,0.7043863430596087,0.1790496008404856,3.03633,-0.7907000000000001,-0.3596317486052831,1.122815,1.3383491256973585,Uncertain,Uncertain,Neutral,Neutral,2.090134511668248,0.4361425742814894,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.2734,0.2371,-6.3369,-3.56420144651336,0.0001429264660025,Benign,0.5469,ambiguous,-3.346,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151M,NP_000537:p.Pro151Met,,,,,saturation_mutlist,,,,,,,,1.53852,1.3144026589393616,,0.07181687261712459,,0.8051684363085624,,Neutral,Uncertain,,Neutral,0.7725484534753954,,0.08720200208844502,1.87854,,-0.005144854638501876,,0.9366975726807492,,Neutral,,Neutral,,0.40961906934434555,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.3054,0.2371,-22.2096,-5.56005426138843,0.4024047053152033,Uncertain,0.9153,pathogenic,-3.956,available,https://doi.org/10.1101/2022.10.22.513328 +P151N,NP_000537:p.Pro151Asn,,,,,saturation_mutlist,,,,,,,,4.08253,2.0878802347183227,,0.9622083274089595,,2.5223691637044796,,Uncertain,Destabilizing,,Uncertain,0.4954564812859412,,0.20775568967060065,2.74812,,0.3431091414840355,,1.5456145707420177,,Uncertain,,Neutral,,0.47303087300553526,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,uncertain,,-0.3324,0.2371,-22.2096,-5.98155647386477,0.6995185679855449,Pathogenic,0.9971,pathogenic,-4.08,available,https://doi.org/10.1101/2022.10.22.513328 +P151Q,NP_000537:p.Pro151Gln,,,,,saturation_mutlist,,,,,,,,3.76146,1.9388776588439942,,0.9204153011886351,,2.3409376505943174,,Uncertain,Uncertain,,Uncertain,0.5684249162752739,,0.18044726004969527,2.60376,,0.5600688992066485,,1.5819144496033242,,Uncertain,,Neutral,,0.6537371141804087,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.3341,0.2371,-22.2096,-6.63561000906772,0.5956876763329336,Uncertain,0.9907,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328 +P151R,NP_000537:p.Pro151Arg,"hg19,17:g.7578478G>C, hg19,17:g.7675160G>C, hg38,17:g.7675160G>C",,,0.912,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376640,Pathogenic/Likely pathogenic,2,,,,,6.86531,1.9975080680847168,7.34875,2.112881625156725,7.10703,4.489095812578363,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.5322960938737313,2.152308132819276,0.34265567419539733,2.6252,0.6153066666666668,0.5226723839456863,1.6202533333333333,1.5739361919728432,Uncertain,Uncertain,Neutral,Neutral,3.8402759347155717,0.6573739951606222,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.3755,0.2371,-22.2096,-6.73559736215129,0.8632261666675214,Pathogenic,0.9897,pathogenic,-4.315,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151S,NP_000537:p.Pro151Ser,"hg19,17:g.7578478_7578479delinsCT, hg19,17:g.7578479G>A, hg19,17:g.7578479_7578480delinsAA, hg19,17:g.7675161G>A, hg38,17:g.7675160_7675161delinsCT, hg38,17:g.7675161G>A",,,0.898,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2700111, 12370","Pathogenic, Pathogenic/Likely pathogenic","1, 2",,,Tier I - Strong,1,4.07136,1.8192879962921142,2.543766666666667,1.3269280314059648,3.3075633333333334,2.6991440157029825,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.6087845508746956,0.060128143345876024,0.20344795800310855,2.08325,-0.38492333333333334,0.6943869372817999,0.8491633333333334,1.3888184686409,Uncertain,Uncertain,Neutral,Neutral,2.1755736839177744,0.6916973942900396,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.2325,0.2371,-7.9218,-4.23585533397574,0.342498808788838,Uncertain,0.961,pathogenic,-3.755,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151T,NP_000537:p.Pro151Thr,"hg19,17:g.7578479G>T, hg19,17:g.7675161G>T, hg38,17:g.7675161G>T",,,0.911,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12369,Pathogenic/Likely pathogenic,2,,,,,3.43116,1.9211003661155701,1.9748299999999999,0.6512657775665898,2.702995,2.0412128887832948,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.7228941799142166,0.7827910537727591,0.27983506005120595,3.4468,-1.0107733333333333,0.466349329316546,1.2180133333333334,1.9565746646582731,Uncertain,Uncertain,Neutral,Neutral,1.6740524228417166,0.606482681899191,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,uncertain,,-0.2497,0.2371,-8.9217,-5.74914592533455,0.332737805680815,Uncertain,0.8944,pathogenic,-3.691,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151V,NP_000537:p.Pro151Val,,,,,saturation_mutlist,,,,,,,,2.47167,1.5845142459869386,,-0.23873471201874663,,1.1164676439906267,,Uncertain,Uncertain,,Neutral,0.822629795297231,,0.22229507386006034,3.22646,,0.040430942418789285,,1.6334454712093947,,Uncertain,,Neutral,,0.668617320360869,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.2323,0.2371,-7.9218,-4.01796100280007,0.2030272121211438,Benign,0.587,pathogenic,-3.659,available,https://doi.org/10.1101/2022.10.22.513328 +P151W,NP_000537:p.Pro151Trp,,,,,saturation_mutlist,,,,,,,,11.34424,1.447057020664215,,1.16354927117477,,6.253894635587384,,Uncertain,Uncertain,,Destabilizing,0.8941459003151803,,0.10617893680104681,5.09156,,-0.43993330355548993,,2.325813348222255,,Uncertain,,Uncertain,,0.34723817810816276,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.3793,0.2371,-22.2096,-6.83338577080362,0.8706225980560897,Pathogenic,0.998,pathogenic,-4.524,available,https://doi.org/10.1101/2022.10.22.513328 +P151Y,NP_000537:p.Pro151Tyr,,,,,saturation_mutlist,,,,,,,,9.70555,1.118359375,,0.6251052462947988,,5.1653276231474,,Uncertain,Uncertain,,Destabilizing,0.9292882715525227,,0.1266143750014664,4.1076,,-0.1775463159482665,,1.9650268420258665,,Uncertain,,Neutral,,0.1690267877558955,1.986,1.691,25.88,18.572,,True,1.986,,neutral,neutral,neutral,,True,25.88,,neutral,neutral,neutral,damaging,,-0.3678,0.2371,-22.2096,-6.47872592104193,0.6212405679009481,Uncertain,0.9965,pathogenic,-4.27,available,https://doi.org/10.1101/2022.10.22.513328 +P152A,NP_000537:p.Pro152Ala,"hg38,17:g.7675158G>C",,,0.803,"COSMIC,saturation_mutlist",,,,,,,,2.17716,1.0828391790390015,1.4600899999999999,0.06538592990482976,1.818625,1.121272964952415,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.4709884468132955,0.186164133137043,0.03738534976338785,1.69444,-0.5768699999999999,0.47891097719225734,0.5587850000000001,1.0866754885961287,Neutral,Neutral,Neutral,Neutral,2.5419728970362105,0.21827728293669268,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,uncertain,,-0.3216,0.0642,-22.2096,-5.61534998839996,0.4881995273608804,Uncertain,0.3011,benign,-3.685,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152C,NP_000537:p.Pro152Cys,,,,,saturation_mutlist,,,,,,,,2.25474,0.8688600850105286,,0.6867724102587811,,1.4707562051293905,,Uncertain,Neutral,,Neutral,0.3095444526768654,,0.02580184776998452,2.48685,,1.0951807924181625,,1.7910153962090813,,Uncertain,,Neutral,,0.1613985310196487,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,uncertain,,-0.3543,0.0642,-22.2096,-6.34524994707572,0.7823151535316585,Pathogenic,0.8229,pathogenic,-4.168,available,https://doi.org/10.1101/2022.10.22.513328 +P152D,NP_000537:p.Pro152Asp,,,,,saturation_mutlist,,,,,,,,1.94221,1.2243050694465638,,-0.27444651291261085,,0.8338817435436946,,Neutral,Uncertain,,Neutral,0.4394800303694171,,0.09779830672745862,4.1933,,1.4411533546083273,,2.8172266773041637,,Uncertain,,Uncertain,,0.34691916029350045,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,uncertain,,-0.3802,0.0642,-22.2096,-6.31870877375324,0.3979095024570115,Uncertain,0.9006,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +P152E,NP_000537:p.Pro152Glu,,,,,saturation_mutlist,,,,,,,,1.52493,1.2312540340423583,,-0.3433695944265948,,0.5907802027867025,,Neutral,Uncertain,,Neutral,0.5045609513797304,,0.10482211410205099,3.98406,,1.4490550780500546,,2.716557539025027,,Uncertain,,Uncertain,,0.7827201083142732,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,neutral,,-0.2962,0.0642,-8.9217,-6.19005314131496,0.0917633181737498,Benign,0.7486,pathogenic,-3.812,available,https://doi.org/10.1101/2022.10.22.513328 +P152F,NP_000537:p.Pro152Phe,,,,,saturation_mutlist,,,,,,,,1.68236,1.2630849480628967,,-0.19550051124852785,,0.7434297443757361,,Neutral,Uncertain,,Neutral,0.36553958368271544,,0.010874061618989319,4.66142,,0.09816762038452459,,2.379793810192262,,Uncertain,,Uncertain,,0.36712204838666446,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,neutral,,-0.3827,0.0642,-22.2096,-6.97284644458033,0.8463963320576667,Pathogenic,0.8822,pathogenic,-4.112,available,https://doi.org/10.1101/2022.10.22.513328 +P152G,NP_000537:p.Pro152Gly,,,,,saturation_mutlist,,,,,,,,2.31151,1.372078664302826,,0.47570954187351705,,1.3936097709367585,,Uncertain,Uncertain,,Neutral,0.43907382787990845,,0.12415475197448082,1.13144,,1.6906891534179633,,1.4110645767089816,,Neutral,,Neutral,,0.14746982144923626,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,uncertain,,-0.336,0.0642,-22.2096,-7.61017213781414,0.7625043073916675,Pathogenic,0.698,pathogenic,-3.908,available,https://doi.org/10.1101/2022.10.22.513328 +P152H,NP_000537:p.Pro152His,,,,,saturation_mutlist,,,,,,,,1.98242,1.326907112598419,,-0.39599592036482667,,0.7932120398175867,,Neutral,Uncertain,,Neutral,0.43540280639268586,,0.056798769319352425,5.23688,,0.5169836393969466,,2.8769318196984734,,Uncertain,,Uncertain,,0.36603849394538623,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,neutral,,-0.2925,0.0642,-8.9217,-6.85045828881582,0.167658588089582,Benign,0.6865,pathogenic,-3.826,available,https://doi.org/10.1101/2022.10.22.513328 +P152I,NP_000537:p.Pro152Ile,,,,,saturation_mutlist,,,,,,,,2.07114,1.32512038230896,,-0.12175105996058155,,0.9746944700197093,,Uncertain,Uncertain,,Neutral,0.38957772020426845,,0.028484668991419066,4.61418,,0.3596611563386916,,2.4869205781693458,,Uncertain,,Uncertain,,0.7402468346124337,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,neutral,,-0.3658,0.0642,-22.2096,-6.0987285320018,0.4066861299350841,Uncertain,0.7032,pathogenic,-3.957,available,https://doi.org/10.1101/2022.10.22.513328 +P152K,NP_000537:p.Pro152Lys,"hg19,17:g.7578475_7578476delinsTT, hg38,17:g.7675157_7675158delinsTT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.53407,1.2019463515281676,1.2863933333333335,-0.29110999875429233,1.4102316666666668,0.6214800006228538,Neutral,Neutral,Uncertain,Neutral,Neutral,0.35972148772070905,0.2526361560734242,0.06184854997668375,2.73265,2.9163266666666665,0.9853219260169911,2.824488333333333,1.8589859630084955,Uncertain,Uncertain,Uncertain,Neutral,2.6692714797653854,0.4355883952294447,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,neutral,,-0.3557,0.0642,-22.2096,-7.28055381223327,0.7691636867311082,Pathogenic,0.7899,pathogenic,-4.206,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152L,NP_000537:p.Pro152Leu,"hg19,17:g.7578475G>A, hg19,17:g.7578475_7578476delinsAA, hg19,17:g.7675157G>A, hg38,17:g.7675157G>A, hg38,17:g.7675157_7675158delinsAA",,7.9594387004e-06,0.878,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142766,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,1.79721,1.1666066598892213,1.33458,-0.3745095549588225,1.565895,0.7113502225205888,Neutral,Neutral,Uncertain,Neutral,Neutral,0.3533069398324193,0.17482135624688416,0.04822326129953022,3.11986,1.5088466666666667,-0.02815633030949254,2.3143533333333335,1.5458518348452537,Uncertain,Uncertain,Uncertain,Neutral,1.1278643528762176,0.6037652801762597,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,neutral,,-0.3026,0.0642,-8.9217,-4.24497340682494,0.0987159823410947,Benign,0.3559,ambiguous,-3.698,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152M,NP_000537:p.Pro152Met,,,,,saturation_mutlist,,,,,,,,1.6524,1.2019628405570983,,-0.07744837526214184,,0.7874758123689292,,Neutral,Uncertain,,Neutral,0.35605667077312686,,0.0571776190815679,2.34167,,0.3013295999202181,,1.321499799960109,,Uncertain,,Neutral,,0.4207281539664128,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,neutral,,-0.3213,0.0642,-22.2096,-5.82982202233048,0.7007870610599661,Pathogenic,0.7186,pathogenic,-3.944,available,https://doi.org/10.1101/2022.10.22.513328 +P152N,NP_000537:p.Pro152Asn,,,,,saturation_mutlist,,,,,,,,2.16784,1.2947697377204894,,-0.11965791018562057,,1.0240910449071896,,Uncertain,Uncertain,,Neutral,0.4212391650822268,,0.05679727345985376,3.2815,,0.7824139459382494,,2.0319569729691245,,Uncertain,,Uncertain,,0.10615142687343437,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,uncertain,,-0.3484,0.0642,-22.2096,-6.00049827692235,0.4872572343487852,Uncertain,0.8625,pathogenic,-3.965,available,https://doi.org/10.1101/2022.10.22.513328 +P152Q,NP_000537:p.Pro152Gln,"hg19,17:g.7578475G>T, hg19,17:g.7675157G>T, hg38,17:g.7675157G>T",,,0.843,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1058730,Uncertain significance,2,,,,,1.79979,1.2103842663764954,1.2642833333333334,-0.027170275561282167,1.5320366666666667,0.8863098622193589,Neutral,Neutral,Uncertain,Neutral,Neutral,0.4298554613800212,0.03038875486462417,0.013958663732729805,2.90708,1.5498833333333335,1.0305695058421618,2.2284816666666667,1.968824752921081,Uncertain,Uncertain,Uncertain,Neutral,1.2792348438118086,0.4082798234420924,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,neutral,,-0.35,0.0642,-22.2096,-5.21034163519331,0.355603825326182,Uncertain,0.5994,pathogenic,-3.7,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152R,NP_000537:p.Pro152Arg,"hg19,17:g.7578475G>C, hg19,17:g.7675157G>C, hg38,17:g.7675157G>C",,,0.853,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",824998,Pathogenic/Likely pathogenic,2,,,Tier II - Potential,1,1.41685,1.2611729764938355,1.39093,-0.3349514760956486,1.40389,0.5409492619521756,Neutral,Neutral,Uncertain,Neutral,Neutral,0.34564081213495496,0.3553396348096658,0.05634499752940124,2.94926,1.4236966666666664,0.34886803580040043,2.1864783333333335,1.6490640179002003,Uncertain,Uncertain,Uncertain,Neutral,0.7111364700408932,0.3660710990316703,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,neutral,,-0.3914,0.0642,-22.2096,-7.52848769412826,0.7960856561445921,Pathogenic,0.6385,pathogenic,-4.184,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152S,NP_000537:p.Pro152Ser,"hg19,17:g.7578476G>A, hg19,17:g.7675158G>A, hg38,17:g.7675158G>A",,3.9791175909e-06,0.863,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",482230,Conflicting classifications of pathogenicity,1,,,,,2.19754,1.1367256736755371,1.48424,-0.05023619032352653,1.84089,1.0736519048382367,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.4296946089046902,0.2388985032742287,0.10453546578312743,2.31925,1.0998866666666667,1.063837437370049,1.7095683333333334,1.6915437186850244,Uncertain,Uncertain,Neutral,Neutral,0.8639591863945633,0.08239819751250997,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,uncertain,,-0.3213,0.0642,-22.2096,-5.6228131894386,0.5117945789926174,Uncertain,0.4796,ambiguous,-3.712,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152T,NP_000537:p.Pro152Thr,"hg19,17:g.7578476G>T, hg38,17:g.7675158G>T",,,0.866,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2687709,Uncertain significance,0,,,,,2.57816,1.3883116507530213,1.677436666666667,-0.06367398838884,2.1277983333333337,1.25724300580558,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.4878168234935538,0.28516550718642125,0.007383799873737942,3.48005,0.9882066666666667,0.9099549483622674,2.2341283333333335,2.1950024741811336,Uncertain,Uncertain,Uncertain,Uncertain,0.8957181755564761,0.21322688677122276,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,uncertain,,-0.3335,0.0642,-22.2096,-5.99199484505145,0.0946032624124289,Benign,0.4973,ambiguous,-3.762,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152V,NP_000537:p.Pro152Val,,,,,saturation_mutlist,,,,,,,,2.39466,1.4192971634864806,,0.010263286679200899,,1.2024616433396005,,Uncertain,Uncertain,,Neutral,0.4565122497658242,,0.042557953217535936,3.701,,0.4482264357985907,,2.0746132178992953,,Uncertain,,Uncertain,,0.4930022246265722,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,neutral,,-0.3212,0.0642,-22.2096,-5.93961873685791,0.4630593926742973,Uncertain,0.5521,ambiguous,-3.814,available,https://doi.org/10.1101/2022.10.22.513328 +P152W,NP_000537:p.Pro152Trp,,,,,saturation_mutlist,,,,,,,,1.97993,1.3306645250320435,,-0.5988601432837898,,0.690534928358105,,Neutral,Uncertain,,Neutral,0.40809695060265927,,0.021311720601463913,6.27407,,-0.14470170325863074,,3.064684148370685,,Uncertain,,Destabilizing,,0.6032627769723131,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,neutral,,-0.3953,0.0642,-22.2096,-7.20207466639269,0.7975974424294667,Pathogenic,0.9495,pathogenic,-4.403,available,https://doi.org/10.1101/2022.10.22.513328 +P152Y,NP_000537:p.Pro152Tyr,,,,,saturation_mutlist,,,,,,,,1.70783,1.2258496642112733,,-0.19757894723514222,,0.7551255263824289,,Neutral,Uncertain,,Neutral,0.38518060224068124,,0.01534734792464322,4.94818,,0.2719481000681821,,2.610064050034091,,Uncertain,,Uncertain,,0.4621034522667355,47.147,7.067,23.055,20.929,,True,47.147,,neutral,neutral,neutral,,True,23.055,,neutral,neutral,neutral,neutral,,-0.3837,0.0642,-22.2096,-7.20207466639269,0.6590475960225636,Uncertain,0.8867,pathogenic,-4.162,available,https://doi.org/10.1101/2022.10.22.513328 +P153A,NP_000537:p.Pro153Ala,"hg19,17:g.7578473G>C, hg38,17:g.7675155G>C",,,0.369,"COSMIC,ClinVar,saturation_mutlist",2687700,Uncertain significance,0,,,,,1.7006,0.2569800043106079,1.04195,0.11463783178410474,1.3712749999999998,0.9076189158920523,Neutral,Neutral,Neutral,Neutral,Neutral,0.15002526436395483,0.06090314934385576,0.05046355878368017,1.37961,0.33514666666666665,-0.17402164296445996,0.8573783333333334,0.6027941785177701,Neutral,Neutral,Neutral,Neutral,1.2511564875301924,0.33886818201882046,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,uncertain,,-0.0671,1.8236,-4.0639,-0.874315076869635,2.249786532269203e-07,Benign,0.0565,benign,-3.029,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P153C,NP_000537:p.Pro153Cys,,,,,saturation_mutlist,,,,,,,,1.82946,0.3917557716369629,,0.7060883048353941,,1.267774152417697,,Neutral,Neutral,,Neutral,0.09381586981879747,,0.060171421672806716,1.54395,,0.516307138564979,,1.0301285692824895,,Neutral,,Neutral,,0.29694056370746014,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,uncertain,,-0.1246,1.8236,-8.9217,-3.37086280585557,0.0453353286221627,Benign,0.2572,benign,-3.718,available,https://doi.org/10.1101/2022.10.22.513328 +P153D,NP_000537:p.Pro153Asp,,,,,saturation_mutlist,,,,,,,,1.6692,0.60557532787323,,0.09462804504604981,,0.8819140225230249,,Neutral,Neutral,,Neutral,0.23956430152727232,,0.3822468643409355,1.2413,,-0.5336044828055991,,0.35384775859720047,,Neutral,,Neutral,,0.3261215649482432,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,uncertain,,-0.2183,1.8236,-22.2096,-2.32569864445034,0.0326449822076869,Benign,0.2563,benign,-3.528,available,https://doi.org/10.1101/2022.10.22.513328 +P153E,NP_000537:p.Pro153Glu,,,,,saturation_mutlist,,,,,,,,1.36124,0.33368958711624147,,-0.10791503389582346,,0.6266624830520883,,Neutral,Neutral,,Neutral,0.11714381650109108,,0.25884146395428853,1.26099,,-0.6031503086868436,,0.3289198456565782,,Neutral,,Neutral,,0.23366557414239522,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,neutral,,-0.2021,1.8236,-22.2096,-2.18010110490429,0.0088438823980619,Benign,0.1445,benign,-3.398,available,https://doi.org/10.1101/2022.10.22.513328 +P153F,NP_000537:p.Pro153Phe,"hg38,17:g.7675154_7675155delinsAA",,,,"COSMIC,saturation_mutlist",,,,,,,,1.43641,0.7954010152816773,1.4363933333333332,-0.3367713390063481,1.4364016666666666,0.549819330496826,Neutral,Neutral,Neutral,Neutral,Neutral,0.1746098960727243,0.3305606536712371,0.08347259113744669,1.15815,0.4883200000000001,-0.4666027761082843,0.823235,0.3457736119458579,Neutral,Neutral,Neutral,Neutral,1.3209815609866276,0.33013365390934346,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,neutral,,-0.2208,1.8236,-22.2096,-1.24668585809957,0.1578705838212771,Benign,0.2715,benign,-3.702,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P153G,NP_000537:p.Pro153Gly,,,,,saturation_mutlist,,,,,,,,1.92644,0.7904413294792175,,0.7675071793991246,,1.3469735896995623,,Neutral,Neutral,,Neutral,0.10725515404365067,,0.3931940122132852,1.08212,,0.34544838046190957,,0.7137841902309547,,Neutral,,Neutral,,0.310591251832632,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,uncertain,,-0.1741,1.8236,-22.2096,-3.95116626630119,0.0007385346702957,Benign,0.2054,benign,-3.628,available,https://doi.org/10.1101/2022.10.22.513328 +P153H,NP_000537:p.Pro153His,"hg19,17:g.7578472G>T, hg38,17:g.7675154G>T",,,0.391,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.76612,0.6819423246383667,1.0480733333333332,-0.2657703190679195,1.4070966666666664,0.7501748404660402,Neutral,Neutral,Neutral,Neutral,Neutral,0.11790759583814761,0.3243919882213835,0.11530650269484435,1.45756,0.36372000000000004,-0.64072600698039,0.91064,0.408416996509805,Neutral,Neutral,Neutral,Neutral,1.251860297077913,0.3580286503616199,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,neutral,,-0.1163,1.8236,-6.1145,-1.71797211950995,0.0018338198631235,Benign,0.1129,benign,-3.326,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P153I,NP_000537:p.Pro153Ile,,,,,saturation_mutlist,,,,,,,,1.63533,0.6722035527229309,,-0.2334703102684356,,0.7009298448657821,,Neutral,Neutral,,Neutral,0.20259946815743393,,0.14251159632316582,2.06737,,-0.4392701117237836,,0.8140499441381082,,Uncertain,,Neutral,,0.23707708853130002,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,neutral,,-0.2039,1.8236,-22.2096,-2.97840143274698,0.2020382289582234,Benign,0.1665,benign,-3.62,available,https://doi.org/10.1101/2022.10.22.513328 +P153K,NP_000537:p.Pro153Lys,,,,,saturation_mutlist,,,,,,,,1.38586,0.6394352889060975,,0.007973540377263314,,0.6969167701886317,,Neutral,Neutral,,Neutral,0.11949695085997261,,0.1802499843502822,1.15811,,-0.4302458363561536,,0.36393208182192316,,Neutral,,Neutral,,0.2523058132072183,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,neutral,,-0.1209,1.8236,-7.9218,-2.60138236025987,0.0041695979268936,Benign,0.1727,benign,-3.443,available,https://doi.org/10.1101/2022.10.22.513328 +P153L,NP_000537:p.Pro153Leu,"hg19,17:g.7578472G>A, hg38,17:g.7675154G>A",,,0.370,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",645432,Uncertain significance,1,,,,,1.39362,0.6688943862915039,1.1665533333333333,-0.4210363319461828,1.2800866666666666,0.4862918340269087,Neutral,Neutral,Neutral,Neutral,Neutral,0.12641817184117338,0.1458715883538974,0.08366559918923511,1.33271,0.12482666666666664,-0.6197583550763908,0.7287683333333334,0.35647582246180465,Neutral,Neutral,Neutral,Neutral,1.2567689481718145,0.2974453205015614,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,neutral,,-0.1182,1.8236,-4.5295,-1.05022549185284,5.174614441888086e-06,Benign,0.0741,benign,-3.076,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P153M,NP_000537:p.Pro153Met,,,,,saturation_mutlist,,,,,,,,1.30548,0.6477467608451843,,-0.08379770165998794,,0.610841149170006,,Neutral,Neutral,,Neutral,0.12720044101746142,,0.026972953669532503,1.42042,,-0.34491724911579186,,0.537751375442104,,Neutral,,Neutral,,0.3322285335262335,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,neutral,,-0.0814,1.8236,-6.9218,-1.97094944864724,0.0001097600894624,Benign,0.1725,benign,-3.308,available,https://doi.org/10.1101/2022.10.22.513328 +P153N,NP_000537:p.Pro153Asn,,,,,saturation_mutlist,,,,,,,,1.85141,0.7713795566558838,,0.16185678545238516,,1.0066333927261926,,Neutral,Neutral,,Neutral,0.11666326789011652,,0.23848191215193196,1.15384,,-0.3554214317026647,,0.39920928414866763,,Neutral,,Neutral,,0.31920630016421647,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,uncertain,,-0.1865,1.8236,-22.2096,-1.72835991884289,0.0302591926167483,Benign,0.1908,benign,-3.581,available,https://doi.org/10.1101/2022.10.22.513328 +P153Q,NP_000537:p.Pro153Gln,,,,,saturation_mutlist,,,,,,,,1.49588,0.5112540125846863,,0.1670172925596567,,0.8314486462798284,,Neutral,Neutral,,Neutral,0.09199236178086555,,0.10097752800665934,1.25042,,-0.21889358395305017,,0.515763208023475,,Neutral,,Neutral,,0.28268982568742046,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,neutral,,-0.08,1.8236,-1.021,-0.384785883446999,7.423362940393784e-05,Benign,0.0872,benign,-3.087,available,https://doi.org/10.1101/2022.10.22.513328 +P153R,NP_000537:p.Pro153Arg,,,,,saturation_mutlist,,,,,,,,1.48961,0.7470243763923645,,-0.12417440820179071,,0.6827177958991046,,Neutral,Neutral,,Neutral,0.1210101062841586,,0.07355644975287576,1.11436,,-0.4929463064276865,,0.3107068467861568,,Neutral,,Neutral,,0.28796690986963475,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,neutral,,-0.1537,1.8236,-7.3368,-0.956192601333636,0.0022283586598844,Benign,0.0975,benign,-3.478,available,https://doi.org/10.1101/2022.10.22.513328 +P153S,NP_000537:p.Pro153Ser,"hg19,17:g.7578473G>A, hg38,17:g.7675155G>A",,,0.359,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",422563,Conflicting classifications of pathogenicity,1,,,,,1.86592,0.38622541666030885,1.1390033333333334,0.24605187994505465,1.5024616666666666,1.0559859399725273,Neutral,Neutral,Neutral,Neutral,Neutral,0.10807900764454786,0.19672875223402292,0.32849248338157444,1.26474,0.35283333333333333,-0.27567319856782235,0.8087866666666667,0.4945334007160888,Neutral,Neutral,Neutral,Neutral,1.4657570871358216,0.3545058369780374,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,uncertain,,-0.0835,1.8236,-7.3368,-2.15873427907793,0.0003502422905545,Benign,0.0929,benign,-3.192,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P153T,NP_000537:p.Pro153Thr,"hg38,17:g.7675155G>T",,,0.382,"COSMIC,saturation_mutlist",,,,,,,,1.81335,0.6452148699760437,1.0819699999999999,0.12323049555844622,1.44766,0.9682902477792231,Neutral,Neutral,Neutral,Neutral,Neutral,0.10384621475855069,0.13497512388090882,0.1886363547969591,1.99812,0.51338,-0.25368507650307776,1.25575,0.872217461748461,Neutral,Neutral,Neutral,Neutral,1.8303436186865751,0.24056387529871973,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,uncertain,,-0.0957,1.8236,-7.3368,-1.49432397380345,0.00257968891441,Benign,0.0862,benign,-3.471,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P153V,NP_000537:p.Pro153Val,,,,,saturation_mutlist,,,,,,,,1.67283,0.6675758624076843,,-0.0613232820745398,,0.8057533589627301,,Neutral,Neutral,,Neutral,0.19807984330420067,,0.1342032930200041,2.16135,,-0.25796060572817225,,0.9516946971359139,,Uncertain,,Neutral,,0.2123275496941039,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,neutral,,-0.0915,1.8236,-8.9217,-1.49025938301281,0.0009013492003504,Benign,0.1116,benign,-3.41,available,https://doi.org/10.1101/2022.10.22.513328 +P153W,NP_000537:p.Pro153Trp,,,,,saturation_mutlist,,,,,,,,1.45872,0.7530018973350525,,-0.6149864729773818,,0.4218667635113091,,Neutral,Neutral,,Neutral,0.13269306866399316,,0.09371418470632761,1.43863,,-0.8216684405302676,,0.30848077973486626,,Neutral,,Neutral,,0.36677547148282225,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,neutral,,-0.2334,1.8236,-22.2096,-3.25959204981253,0.5377588861213921,Uncertain,0.3747,ambiguous,-4.002,available,https://doi.org/10.1101/2022.10.22.513328 +P153Y,NP_000537:p.Pro153Tyr,,,,,saturation_mutlist,,,,,,,,1.4326,0.7150468730926514,,-0.2830806786073599,,0.5747596606963201,,Neutral,Neutral,,Neutral,0.15652430878453516,,0.03297716518567065,1.17904,,-0.44082605269960884,,0.3691069736501956,,Neutral,,Neutral,,0.3505727834641073,83.457,12.768,70.925,23.828,,False,83.457,,neutral,neutral,neutral,,False,70.925,,neutral,neutral,neutral,neutral,,-0.2218,1.8236,-22.2096,-3.25959204981253,0.2359348155010482,Benign,0.2758,benign,-3.86,available,https://doi.org/10.1101/2022.10.22.513328 +G154A,NP_000537:p.Gly154Ala,"hg19,17:g.7578469C>G, hg38,17:g.7675151C>G",,,0.728,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2840669,Uncertain significance,1,,,,,3.22417,1.40707200050354,1.8336733333333335,1.6001802303732475,2.5289216666666667,2.4121751151866238,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.20162492096117063,0.09650705857892246,0.2828541580549345,1.65432,0.5003433333333333,1.4657403836936893,1.0773316666666666,1.5600301918468447,Neutral,Neutral,Neutral,Neutral,0.46152223849151863,0.5345248882468412,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.3571,0.2867,-22.2096,-4.06697645914284,0.0048197395846311,Benign,0.2768,benign,-3.708,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154C,NP_000537:p.Gly154Cys,"hg19,17:g.7578470C>A, hg38,17:g.7675152C>A",,,0.715,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1741887,Uncertain significance,1,,,,,3.20221,0.6955515575408936,2.4328800000000004,1.980337970683605,2.817545,2.5912739853418025,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.10372530155900628,0.121674839634166,0.29588501712399606,1.69576,0.6243766666666667,1.961970706565242,1.1600683333333333,1.828865353282621,Neutral,Neutral,Neutral,Neutral,1.0461660977535492,0.5041711711852475,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.3491,0.2867,-8.9217,-4.08463118414522,0.7262429897836769,Pathogenic,0.3408,ambiguous,-4.008,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154D,NP_000537:p.Gly154Asp,"hg19,17:g.7578468_7578469delinsAT, hg19,17:g.7578469C>T, hg38,17:g.7675150_7675151delinsAT, hg38,17:g.7675151C>T",,7.9595020536e-06,0.721,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2687710, 237950","Uncertain significance, Uncertain significance","0, 3",,,,,3.21043,1.1002883696556092,1.1970500000000002,0.8670244574176594,2.2037400000000003,2.03872722870883,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.15715902074312682,0.07018433490934184,0.3089946791203187,1.49281,0.24274666666666667,0.7330141922005319,0.8677783333333333,1.1129120961002659,Neutral,Neutral,Neutral,Neutral,0.5801203593125214,0.6437265411751334,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.3415,0.2867,-7.3368,-1.7982562863318,0.0048849083524315,Benign,0.261,benign,-3.496,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154E,NP_000537:p.Gly154Glu,,,,,saturation_mutlist,,,,,,,,3.18646,1.271516616344452,,1.2230332694827037,,2.204746634741352,,Uncertain,Uncertain,,Uncertain,0.16044749703512726,,0.3308100699165021,1.57269,,1.1546237716565309,,1.3636568858282654,,Neutral,,Neutral,,0.5741402678061995,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.4167,0.2867,-22.2096,-5.5249117406559,0.4687762801003565,Uncertain,0.3976,ambiguous,-3.74,available,https://doi.org/10.1101/2022.10.22.513328 +G154F,NP_000537:p.Gly154Phe,,,,,saturation_mutlist,,,,,,,,3.17455,1.2469673609733583,,1.202101823114767,,2.1883259115573837,,Uncertain,Uncertain,,Uncertain,0.1702589910860108,,0.37723171399562794,1.43757,,0.7269031248732186,,1.0822365624366093,,Neutral,,Neutral,,0.4336882464532899,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.455,0.2867,-22.2096,-6.2525132521354,0.5858204996671974,Uncertain,0.6849,pathogenic,-4.115,available,https://doi.org/10.1101/2022.10.22.513328 +G154H,NP_000537:p.Gly154His,,,,,saturation_mutlist,,,,,,,,3.25821,1.2284024453163147,,0.7112037800724188,,1.9847068900362095,,Uncertain,Uncertain,,Neutral,0.15938441907671505,,0.32167603837947034,1.68578,,0.6607874965088807,,1.1732837482544403,,Neutral,,Neutral,,0.48107162223791256,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.4297,0.2867,-22.2096,-2.76642961177661,0.2059169021416705,Benign,0.479,ambiguous,-3.839,available,https://doi.org/10.1101/2022.10.22.513328 +G154I,NP_000537:p.Gly154Ile,"hg19,17:g.7578469_7578470delinsAT, hg38,17:g.7675151_7675152delinsAT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,4.92565,1.9256968593597412,5.49671,2.745051432703105,5.211180000000001,3.8353507163515523,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.31869816445267135,0.14996967493463464,0.44963250647907627,3.48323,3.825396666666667,2.235875930753446,3.6543133333333335,2.859552965376723,Destabilizing,Uncertain,Destabilizing,Uncertain,1.3234538448653541,0.7171337538159314,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.5007,0.2867,-22.2096,-6.63131476926816,0.824655192806746,Pathogenic,0.7892,pathogenic,-4.296,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154K,NP_000537:p.Gly154Lys,,,,,saturation_mutlist,,,,,,,,2.92565,1.4904424858093261,,0.9366920117658437,,1.931171005882922,,Uncertain,Uncertain,,Neutral,0.19121580924955034,,0.26529196207464856,1.3387,,1.0530670808179596,,1.1958835404089798,,Neutral,,Neutral,,0.38690179998370766,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.4496,0.2867,-22.2096,-5.36388597125634,0.1566504546564236,Benign,0.7454,pathogenic,-3.793,available,https://doi.org/10.1101/2022.10.22.513328 +G154L,NP_000537:p.Gly154Leu,,,,,saturation_mutlist,,,,,,,,3.16485,1.4414742088317871,,1.2366636464275413,,2.2007568232137706,,Uncertain,Uncertain,,Uncertain,0.19207006020557021,,0.351665244164741,1.69532,,0.8570493043994601,,1.27618465219973,,Neutral,,Neutral,,0.5973267459815571,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.4689,0.2867,-22.2096,-6.29531104381167,0.5919993205407742,Uncertain,0.6683,pathogenic,-3.999,available,https://doi.org/10.1101/2022.10.22.513328 +G154M,NP_000537:p.Gly154Met,,,,,saturation_mutlist,,,,,,,,2.9544,1.3164429545402527,,1.2487417256535072,,2.1015708628267538,,Uncertain,Uncertain,,Uncertain,0.16231189356112177,,0.28943834447846145,1.86674,,1.08006950344006,,1.4734047517200302,,Neutral,,Neutral,,0.5275006567270856,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.4071,0.2867,-22.2096,-6.63131476926816,0.7870712756526672,Pathogenic,0.6961,pathogenic,-4.139,available,https://doi.org/10.1101/2022.10.22.513328 +G154N,NP_000537:p.Gly154Asn,,,,,saturation_mutlist,,,,,,,,2.72156,0.9712605166435242,,0.5266782667115879,,1.624119133355794,,Uncertain,Neutral,,Neutral,0.17234560745010374,,0.1495438549001782,1.32056,,0.6323260302381543,,0.976443015119077,,Neutral,,Neutral,,0.4193425665339773,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.3397,0.2867,-6.9218,-1.81209055051064,0.0095337485631653,Benign,0.2439,benign,-3.436,available,https://doi.org/10.1101/2022.10.22.513328 +G154P,NP_000537:p.Gly154Pro,,,,,saturation_mutlist,,,,,,,,6.03088,2.099575233459473,,6.68861515761128,,6.35974757880564,,Destabilizing,Destabilizing,,Destabilizing,0.343421747019069,,0.3315312514911453,3.26098,,5.614495679403293,,4.437737839701647,,Destabilizing,,Destabilizing,,0.8773375351434033,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.5148,0.2867,-22.2096,-5.79795393822105,0.0258027473354065,Benign,0.94,pathogenic,-3.802,available,https://doi.org/10.1101/2022.10.22.513328 +G154Q,NP_000537:p.Gly154Gln,,,,,saturation_mutlist,,,,,,,,2.89033,1.4181983184814453,,1.257990252874165,,2.0741601264370826,,Uncertain,Uncertain,,Uncertain,0.1616660762104605,,0.27627998975223905,1.39253,,1.3148000935283626,,1.3536650467641813,,Neutral,,Neutral,,0.5247018446633749,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.4206,0.2867,-22.2096,-4.56866968611123,0.1354306687201455,Benign,0.4827,ambiguous,-3.738,available,https://doi.org/10.1101/2022.10.22.513328 +G154R,NP_000537:p.Gly154Arg,"hg19,17:g.7578470C>G, hg38,17:g.7675152C>G",,,0.711,"COSMIC,ClinVar,saturation_mutlist",482229,Uncertain significance,3,,,,,2.61594,1.5125912761688232,1.6967133333333333,0.9465890255918098,2.1563266666666667,1.781264512795905,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.215416887363098,0.1009418123915402,0.3231537401287079,1.43336,0.5400233333333334,0.9773126800770466,0.9866916666666667,1.2053363400385233,Neutral,Neutral,Neutral,Neutral,0.3664791044824005,0.3691844607268091,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.4337,0.2867,-22.2096,-5.51523440597117,0.051699364391038,Benign,0.5843,pathogenic,-3.662,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154S,NP_000537:p.Gly154Ser,"hg19,17:g.7578470C>T, hg19,17:g.7675152C>T, hg38,17:g.7675152C>T",0.0001593371574251,3.9800678204e-06,0.638,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",133284,Uncertain significance,2,,,Tier I - Strong,1,3.46787,1.3942234230041504,1.49297,1.3833009779344965,2.48042,2.4255854889672483,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.18254935426468807,0.2141207511351169,0.2236773418546765,1.90543,0.3680266666666667,1.2835409624119325,1.1367283333333333,1.5944854812059663,Neutral,Neutral,Neutral,Neutral,0.5351366236350822,0.5194425970034001,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.2799,0.2867,-5.9218,-2.15790889825012,8.703142915299439e-06,Benign,0.1525,benign,-3.21,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154T,NP_000537:p.Gly154Thr,,,,,saturation_mutlist,,,,,,,,5.02847,1.6695435571670532,,2.2046690747546447,,3.6165695373773223,,Uncertain,Uncertain,,Destabilizing,0.2509499163763332,,0.39547074628798645,3.05497,,2.0284746308048063,,2.541722315402403,,Uncertain,,Uncertain,,0.6268925351076101,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.4399,0.2867,-22.2096,-5.6807562113225,0.4636622333212558,Uncertain,0.3805,ambiguous,-3.851,available,https://doi.org/10.1101/2022.10.22.513328 +G154V,NP_000537:p.Gly154Val,"hg19,17:g.7578468_7578469delinsAA, hg19,17:g.7578469C>A, hg19,17:g.7675150_7675151delinsAA, hg19,17:g.7675151C>A, hg38,17:g.7675151C>A",,,0.754,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",651769,Conflicting classifications of pathogenicity,1,,,,,5.03213,1.9483468770980834,5.6866200000000005,2.568385705096327,5.359375,3.800257852548164,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.3067112704472858,0.11962285261047177,0.3550960235007091,3.2883,3.26474,2.185048073094549,3.27652,2.7366740365472744,Destabilizing,Uncertain,Destabilizing,Uncertain,1.8360454155784565,0.719898913888067,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.4439,0.2867,-22.2096,-6.63131476926816,0.5039223527564188,Uncertain,0.5817,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154W,NP_000537:p.Gly154Trp,,,,,saturation_mutlist,,,,,,,,3.36151,1.4423013162612914,,1.0239160328467445,,2.1927130164233724,,Uncertain,Uncertain,,Uncertain,0.18702967442590648,,0.34658920841256174,2.05951,,0.5437915111244757,,1.3016507555622379,,Uncertain,,Neutral,,0.5487490885819122,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.387,0.2867,-8.9217,-4.4684824170351,0.0020514383442931,Benign,0.6447,pathogenic,-3.978,available,https://doi.org/10.1101/2022.10.22.513328 +G154Y,NP_000537:p.Gly154Tyr,,,,,saturation_mutlist,,,,,,,,3.22033,1.348734655380249,,1.2340864623771655,,2.227208231188583,,Uncertain,Uncertain,,Uncertain,0.17563544465890613,,0.3581528792297433,1.5914,,0.9114781927333256,,1.2514390963666628,,Neutral,,Neutral,,0.4881876124084369,49.693,11.134,85.115,25.705,,False,49.693,,neutral,neutral,neutral,,False,85.115,,neutral,neutral,neutral,uncertain,,-0.4554,0.2867,-22.2096,-6.2525132521354,0.7516188939142655,Pathogenic,0.5469,ambiguous,-4.181,available,https://doi.org/10.1101/2022.10.22.513328 +T155A,NP_000537:p.Thr155Ala,"hg19,17:g.7578467T>C, hg38,17:g.7675149T>C",,7.9589319113e-06,0.337,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458544,Conflicting classifications of pathogenicity,1,,,,,1.23969,1.595731258392334,0.17686666666666664,1.2342425256721714,0.7082783333333333,1.2369662628360856,Neutral,Neutral,Uncertain,Neutral,Neutral,0.450778786986588,0.1207184029973153,0.35348374047479164,-0.84627,0.11916,0.12653585250309662,-0.36355499999999996,-0.35986707374845167,Neutral,Neutral,Neutral,Neutral,0.9313272391950461,0.08493990891470087,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,damaging,uncertain,P,False,1.375,14.358,uncertain,damaging,uncertain,neutral,,-0.0844,1.4012,-0.7926,-0.502175641617173,5.17365220891069e-10,Benign,0.086,benign,-2.922,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155C,NP_000537:p.Thr155Cys,,,,,saturation_mutlist,,,,,,,,0.86432,1.2786222505569458,,1.275697858469582,,1.070008929234791,,Neutral,Uncertain,,Neutral,0.36926092043798125,,0.17623923370341096,-0.3069,,0.6539319873715097,,0.17351599368575485,,Neutral,,Neutral,,0.13696747772555182,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,damaging,uncertain,P,False,1.375,14.358,uncertain,damaging,uncertain,neutral,,-0.1617,1.4012,-8.9217,-2.12783777709344,0.0002307191847469,Benign,0.2118,benign,-3.298,available,https://doi.org/10.1101/2022.10.22.513328 +T155D,NP_000537:p.Thr155Asp,,,,,saturation_mutlist,,,,,,,,3.95794,3.0134024238586425,,2.8367516725689286,,3.3973458362844644,,Uncertain,Destabilizing,,Destabilizing,0.20743815142073976,,0.06152150307047765,4.26602,,1.8374343706258252,,3.0517271853129126,,Uncertain,,Destabilizing,,0.2806540439319708,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,neutral,uncertain,P,False,1.375,14.358,uncertain,neutral,uncertain,uncertain,,-0.3093,1.4012,-22.2096,-5.25779070973747,0.43338854297156,Uncertain,0.9629,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328 +T155E,NP_000537:p.Thr155Glu,,,,,saturation_mutlist,,,,,,,,4.10881,3.0794961738586424,,2.47860845159486,,3.2937092257974303,,Uncertain,Destabilizing,,Destabilizing,0.19510064962881746,,0.10464870788986803,5.83141,,1.5655789463160688,,3.6984944731580343,,Uncertain,,Destabilizing,,0.5671449421754834,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,neutral,uncertain,P,False,1.375,14.358,uncertain,neutral,uncertain,neutral,,-0.2846,1.4012,-22.2096,-5.25779070973747,0.6595253329014732,Uncertain,0.9695,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +T155F,NP_000537:p.Thr155Phe,"hg19,17:g.7578466_7578467delinsAA",,,,"cBioPortal,saturation_mutlist",,,,,,,,2.32027,1.617471284866333,7.289113333333333,1.3522975186115034,4.804691666666667,1.8362837593057515,Uncertain,Uncertain,Uncertain,Destabilizing,Neutral,0.414065194910232,1.0054220288791949,0.42321218145330136,11.14318,1.8213133333333333,0.14619013907862763,6.482246666666667,5.644685069539314,Uncertain,Uncertain,Destabilizing,Destabilizing,2.095851439174277,0.29004411288159665,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,uncertain,uncertain,P,False,1.375,14.358,uncertain,neutral,uncertain,neutral,,-0.301,1.4012,-22.2096,-4.17937261647989,0.0084138522792774,Benign,0.8902,pathogenic,-3.608,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155G,NP_000537:p.Thr155Gly,,,,,saturation_mutlist,,,,,,,,3.02471,2.542743501663208,,3.3665037255547197,,3.1956068627773595,,Destabilizing,Destabilizing,,Destabilizing,0.4113971226666919,,0.549858889396921,-0.33395,,1.8022683899405931,,0.7341591949702966,,Neutral,,Neutral,,0.363198896575295,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,neutral,uncertain,P,False,1.375,14.358,uncertain,damaging,uncertain,neutral,,-0.1994,1.4012,-8.9217,-3.6640752121291,0.6432123765778344,Uncertain,0.3793,ambiguous,-3.866,available,https://doi.org/10.1101/2022.10.22.513328 +T155H,NP_000537:p.Thr155His,,,,,saturation_mutlist,,,,,,,,5.09032,2.4559095811843874,,1.8852298834240926,,3.4877749417120465,,Uncertain,Destabilizing,,Destabilizing,0.3165409073008786,,0.24831842808386212,10.69513,,0.6548803265050885,,5.6750051632525444,,Uncertain,,Destabilizing,,0.3844413421566472,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,neutral,uncertain,P,False,1.375,14.358,uncertain,neutral,uncertain,neutral,,-0.2813,1.4012,-22.2096,-4.89973092444482,0.2478314655462414,Benign,0.8989,pathogenic,-3.82,available,https://doi.org/10.1101/2022.10.22.513328 +T155I,NP_000537:p.Thr155Ile,"hg19,17:g.7578466G>A, hg19,17:g.7675148G>A, hg38,17:g.7675148G>A",,,0.597,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1005876,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,-0.36205,1.0613718986511231,0.5298166666666667,-0.28202109976428597,0.08388333333333337,-0.322035549882143,Neutral,Neutral,Uncertain,Neutral,Neutral,0.4082438025309486,0.6754934355137897,0.26184162331232314,1.7577,0.13163333333333335,-0.173969809700627,0.9446666666666667,0.7918650951496865,Neutral,Neutral,Neutral,Neutral,0.912694812276018,0.7257418642066967,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,damaging,uncertain,P,False,1.375,14.358,uncertain,damaging,uncertain,neutral,,-0.2196,1.4012,-22.2096,-4.0458363280804,0.0970850981108774,Benign,0.833,pathogenic,-3.74,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155K,NP_000537:p.Thr155Lys,,,,,saturation_mutlist,,,,,,,,2.20153,2.831649694442749,,3.229835445560188,,2.7156827227800937,,Uncertain,Destabilizing,,Uncertain,0.24488721910256311,,0.3246781561063856,3.70143,,1.882946352572055,,2.7921881762860274,,Uncertain,,Uncertain,,0.2756661312508888,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,uncertain,uncertain,P,False,1.375,14.358,uncertain,neutral,uncertain,neutral,,-0.2768,1.4012,-22.2096,-5.80513631646375,0.5115064373436632,Uncertain,0.974,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328 +T155L,NP_000537:p.Thr155Leu,"hg38,17:g.7675147_7675149delinsAAG",,,,"COSMIC,saturation_mutlist",,,,,,,,-0.39151,1.6095757818222045,3.0948966666666666,0.05309858973372993,1.3516933333333334,-0.16920570513313504,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.29854157920344815,1.560482547170016,0.12811340991406112,0.79578,0.12879666666666667,-0.37917901797123116,0.46228833333333336,0.20830049101438444,Neutral,Neutral,Neutral,Neutral,1.5499192099446846,0.8331413099891121,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,damaging,uncertain,P,False,1.375,14.358,uncertain,damaging,uncertain,neutral,,-0.2716,1.4012,-22.2096,-3.85120811517604,0.0077627384209902,Benign,0.581,pathogenic,-3.426,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155M,NP_000537:p.Thr155Met,,,,,saturation_mutlist,,,,,,,,0.12358,1.614674711227417,,0.8205667782357894,,0.4720733891178947,,Neutral,Uncertain,,Neutral,0.25749366092570225,,0.21715685551788652,0.96866,,0.1448815727574058,,0.5567707863787029,,Neutral,,Neutral,,0.6173200512976539,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,damaging,uncertain,P,False,1.375,14.358,uncertain,damaging,uncertain,neutral,,-0.2385,1.4012,-22.2096,-4.35519053423558,0.270420382624247,Benign,0.4361,ambiguous,-3.558,available,https://doi.org/10.1101/2022.10.22.513328 +T155N,NP_000537:p.Thr155Asn,"hg19,17:g.7578466G>C, hg19,17:g.7578466G>T, hg19,17:g.7675148G>T, hg38,17:g.7675148G>T",3.18775900542e-05,,0.548,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406564,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,2.08508,2.539779462814331,2.351246666666667,1.6404109534140332,2.2181633333333335,1.8627454767070166,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,0.21337613643982192,0.4747813943513607,0.0854389806491691,1.18408,1.1730166666666666,0.6923503569917514,1.1785483333333333,0.9382151784958757,Neutral,Neutral,Neutral,Neutral,0.46836074076387835,0.2716536621838929,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,uncertain,uncertain,P,False,1.375,14.358,uncertain,damaging,uncertain,uncertain,,-0.2493,1.4012,-22.2096,-4.96926233526373,0.6662515345562836,Uncertain,0.7722,pathogenic,-3.902,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155P,NP_000537:p.Thr155Pro,"hg19,17:g.7578467T>G, hg19,17:g.7675149T>G, hg38,17:g.7675149T>G",,,0.581,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2768025,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,3.55489,2.8219685840606687,8.66848,5.674851654215871,6.1116850000000005,4.614870827107936,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.2860456744706218,1.0052149546572948,0.7806723384756111,1.30063,5.231176666666667,4.606440551392961,3.2659033333333336,2.9535352756964803,Uncertain,Uncertain,Destabilizing,Uncertain,2.5609973103764787,0.6340005450402513,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,neutral,uncertain,P,False,1.375,14.358,uncertain,damaging,uncertain,uncertain,,-0.358,1.4012,-22.2096,-5.80513631646375,0.5827820910167374,Uncertain,0.9028,pathogenic,-3.827,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155Q,NP_000537:p.Thr155Gln,,,,,saturation_mutlist,,,,,,,,2.56061,2.5631813430786132,,1.7670827081897222,,2.1638463540948614,,Uncertain,Destabilizing,,Uncertain,0.19348675943780902,,0.07872070953529055,3.35057,,0.857482282357313,,2.1040261411786565,,Uncertain,,Uncertain,,0.47141063807592964,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,uncertain,uncertain,P,False,1.375,14.358,uncertain,neutral,uncertain,neutral,,-0.2588,1.4012,-22.2096,-5.25779070973747,0.4677811848233746,Uncertain,0.9165,pathogenic,-3.924,available,https://doi.org/10.1101/2022.10.22.513328 +T155R,NP_000537:p.Thr155Arg,,,,,saturation_mutlist,,,,,,,,2.89302,2.495144176483154,,2.3730453182007807,,2.6330326591003903,,Uncertain,Destabilizing,,Uncertain,0.2400978424916727,,0.34614749777017184,6.49604,,0.9512071870159415,,3.7236235935079707,,Uncertain,,Destabilizing,,0.29639229614219204,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,uncertain,uncertain,P,False,1.375,14.358,uncertain,neutral,uncertain,neutral,,-0.2796,1.4012,-22.2096,-5.80513631646375,0.5146723951322584,Uncertain,0.9479,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +T155S,NP_000537:p.Thr155Ser,"hg19,17:g.7578466G>C, hg38,17:g.7675148G>C, hg38,17:g.7675149T>A",3.18775900542e-05,,"0.359, 0.424","cBioPortal,COSMIC,ClinVar,saturation_mutlist",186179,Conflicting classifications of pathogenicity,1,,,,,1.52811,1.0578882551193238,1.0548766666666667,2.154122160035613,1.2914933333333334,1.8411160800178066,Neutral,Uncertain,Uncertain,Neutral,Neutral,0.2813594852146521,0.17195695087886254,0.3813786373002626,-0.56271,0.8351466666666667,0.9843173732094987,0.13621833333333333,0.21080368660474935,Neutral,Neutral,Neutral,Neutral,1.2596181625750278,0.11661569696937342,3.248,2.376,1.375,1.921,P,False,3.248,9.196,neutral,damaging,uncertain,P,False,1.375,14.358,neutral,damaging,uncertain,neutral,,-0.0588,1.4012,-2.8775,-0.0793354338503833,1.381761769595731e-10,Benign,0.0875,benign,-2.882,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155V,NP_000537:p.Thr155Val,,,,,saturation_mutlist,,,,,,,,-0.25264,0.9599983882904053,,-0.29272062519464087,,-0.2726803125973204,,Neutral,Neutral,,Neutral,0.405140432686857,,0.1832240837539866,0.31153,,-0.39228882648526686,,-0.040379413242633444,,Neutral,,Neutral,,0.5072788197759321,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,damaging,uncertain,P,False,1.375,14.358,uncertain,damaging,uncertain,neutral,,-0.2072,1.4012,-22.2096,-4.11351162520015,0.0237703039281077,Benign,0.517,ambiguous,-3.446,available,https://doi.org/10.1101/2022.10.22.513328 +T155W,NP_000537:p.Thr155Trp,,,,,saturation_mutlist,,,,,,,,7.35056,1.9461833238601685,,2.2567369592568305,,4.803648479628415,,Uncertain,Uncertain,,Destabilizing,0.36412244006107336,,0.5025994027052886,20.00389,,0.5823208586864923,,10.293105429343246,,Uncertain,,Destabilizing,,0.0568952694149104,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,neutral,uncertain,P,False,1.375,14.358,uncertain,neutral,uncertain,neutral,,-0.2939,1.4012,-22.2096,-4.89973092444482,0.7255516461548432,Pathogenic,0.9699,pathogenic,-4.034,available,https://doi.org/10.1101/2022.10.22.513328 +T155Y,NP_000537:p.Thr155Tyr,,,,,saturation_mutlist,,,,,,,,3.68543,1.7819746160507202,,2.2128331885494674,,2.949131594274734,,Uncertain,Uncertain,,Uncertain,0.4365254961813055,,0.48346065108417285,14.79555,,0.6579869435431233,,7.726768471771562,,Uncertain,,Destabilizing,,0.053910379401292535,3.248,2.376,1.375,1.921,P,False,3.248,9.196,uncertain,neutral,uncertain,P,False,1.375,14.358,uncertain,neutral,uncertain,neutral,,-0.3024,1.4012,-22.2096,-4.52348740602341,0.0277192915295778,Benign,0.9178,pathogenic,-3.77,available,https://doi.org/10.1101/2022.10.22.513328 +R156A,NP_000537:p.Arg156Ala,,,,,saturation_mutlist,,,,,,,,1.28777,1.240013689994812,,1.1043745045677482,,1.1960722522838743,,Neutral,Uncertain,,Neutral,0.3185608911153355,,0.2431218038300243,0.92371,,0.8985290004424772,,0.9111195002212387,,Neutral,,Neutral,,0.05761274247377857,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.1423,1.8853,-3.7926,-1.75738707360167,0.0018230464683667,Benign,0.6224,pathogenic,-3.322,available,https://doi.org/10.1101/2022.10.22.513328 +R156C,NP_000537:p.Arg156Cys,"hg19,17:g.7578464G>A, hg19,17:g.7675146G>A, hg38,17:g.7675146G>A",,3.9795926489e-06,0.493,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127810,Conflicting classifications of pathogenicity,1,,,Tier II - Potential,1,1.10026,0.32212793350219726,0.8243766666666666,1.57893951136409,0.9623183333333334,1.3395997556820451,Neutral,Neutral,Neutral,Neutral,Neutral,0.3437266997915168,0.10490579911944278,0.2750834824049855,0.65753,1.13696,1.2871310774352989,0.897245,0.9723305387176494,Neutral,Neutral,Neutral,Neutral,0.13199930631130863,0.15836311701510422,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.1596,1.8853,-5.4624,-0.336239047499407,1.8857099437031558e-07,Benign,0.1809,benign,-3.093,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R156D,NP_000537:p.Arg156Asp,,,,,saturation_mutlist,,,,,,,,2.55013,2.300440731048584,,1.811770574941308,,2.1809502874706537,,Uncertain,Destabilizing,,Uncertain,0.3719201515499935,,0.519937516550481,1.55921,,0.8619001585574514,,1.2105550792787256,,Neutral,,Neutral,,0.11620941343988443,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.3273,1.8853,-22.2096,-3.99777403960999,0.0416513387702734,Benign,0.9323,pathogenic,-3.954,available,https://doi.org/10.1101/2022.10.22.513328 +R156E,NP_000537:p.Arg156Glu,,,,,saturation_mutlist,,,,,,,,1.64313,1.5425394487380981,,1.456701779101283,,1.5499158895506415,,Neutral,Uncertain,,Neutral,0.42394607875426915,,0.3336149110349146,0.75826,,0.6774130349866786,,0.7178365174933393,,Neutral,,Neutral,,0.11892994278199033,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.2725,1.8853,-22.2096,-3.99777403960999,0.0234122196083114,Benign,0.6494,pathogenic,-3.656,available,https://doi.org/10.1101/2022.10.22.513328 +R156F,NP_000537:p.Arg156Phe,,,,,saturation_mutlist,,,,,,,,0.4852,0.26330831050872805,,0.1819523613018675,,0.33357618065093375,,Neutral,Neutral,,Neutral,0.3413451520587549,,0.010438079097775282,-0.32147,,0.052237855436335766,,-0.13461607228183212,,Neutral,,Neutral,,0.10575549679894639,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.1925,1.8853,-7.3368,-1.95874375949082,5.2824297054384814e-05,Benign,0.5958,pathogenic,-3.321,available,https://doi.org/10.1101/2022.10.22.513328 +R156G,NP_000537:p.Arg156Gly,"hg19,17:g.7578464G>C, hg19,17:g.7675146G>C, hg38,17:g.7675146G>C",,,0.580,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1517870,Conflicting classifications of pathogenicity,1,,,,,2.4499,1.9645683717727662,1.9448999999999999,2.2264583339431154,2.1974,2.3381791669715577,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.39463265214055177,0.5365468869229107,0.3935261590957794,1.88278,2.591156666666667,1.7998930745525994,2.2369683333333334,1.8413365372762995,Uncertain,Neutral,Uncertain,Neutral,0.43173330999073456,0.17966107981990076,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.2716,1.8853,-22.2096,-2.72461497518018,0.029281218090832,Benign,0.6544,pathogenic,-3.652,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R156H,NP_000537:p.Arg156His,"hg19,17:g.7578463C>T, hg19,17:g.7675145C>T, hg38,17:g.7675145C>T",,1.59192575258e-05,0.627,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127811,Uncertain significance,3,,,,,1.29271,0.7759644436836243,0.15136000000000002,0.731167546668674,0.722035,1.011938773334337,Neutral,Neutral,Neutral,Neutral,Neutral,0.29062197766521597,0.10695044304100226,0.23521032550253398,0.59364,0.8339,0.2881278070947903,0.71377,0.44088390354739515,Neutral,Neutral,Neutral,Neutral,0.37463553337432726,0.06936576839420204,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.1382,1.8853,-8.9217,-1.69809690112553,0.000146432999198,Benign,0.1586,benign,-3.206,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R156I,NP_000537:p.Arg156Ile,,,,,saturation_mutlist,,,,,,,,0.08688,0.3540168738365173,,0.4867903051827755,,0.28683515259138775,,Neutral,Neutral,,Neutral,0.2595326449456371,,0.419711976975454,-0.17237,,-0.1318063525626269,,-0.15208817628131344,,Neutral,,Neutral,,0.060928559566876844,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.1702,1.8853,-3.4956,-0.789150660647624,6.029404715997523e-08,Benign,0.3879,ambiguous,-3.026,available,https://doi.org/10.1101/2022.10.22.513328 +R156K,NP_000537:p.Arg156Lys,,,,,saturation_mutlist,,,,,,,,-0.02596,0.3304894876480102,,0.9491724756500678,,0.4616062378250339,,Neutral,Neutral,,Neutral,0.15580478576327114,,0.3070067853850228,-0.24652,,0.6019029668184463,,0.1776914834092232,,Neutral,,Neutral,,0.026068292585761883,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.1265,1.8853,-22.2096,-2.63040850174089,0.0343168503203364,Benign,0.18,benign,-3.268,available,https://doi.org/10.1101/2022.10.22.513328 +R156L,NP_000537:p.Arg156Leu,"hg19,17:g.7578463C>A, hg38,17:g.7675145C>A",,,0.512,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.15649,0.34609417915344237,-0.26315000000000005,0.12653151931473128,-0.20982,-0.014979240342634356,Neutral,Neutral,Neutral,Neutral,Neutral,0.4628832841583285,0.3282772038993874,0.12471749058543313,-0.69038,-0.2599766666666667,-0.15271311340066498,-0.47517833333333337,-0.4215465567003325,Neutral,Neutral,Neutral,Neutral,0.20148991775162242,0.0420291259748166,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.1539,1.8853,-5.5999,-0.83890271459001,2.1034771397284842e-08,Benign,0.3339,benign,-3.058,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R156M,NP_000537:p.Arg156Met,,,,,saturation_mutlist,,,,,,,,-0.30128,0.3682043766975403,,0.5323665025936933,,0.11554325129684667,,Neutral,Neutral,,Neutral,0.3337419405503526,,0.09734305024609348,-0.53274,,0.29615578564236167,,-0.11829210717881916,,Neutral,,Neutral,,0.08812024749074897,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.1206,1.8853,-5.7519,-0.862060368096797,7.089547537643953e-07,Benign,0.4523,ambiguous,-3.16,available,https://doi.org/10.1101/2022.10.22.513328 +R156N,NP_000537:p.Arg156Asn,,,,,saturation_mutlist,,,,,,,,1.38882,1.2596425819396972,,1.151926062239249,,1.2703730311196244,,Neutral,Uncertain,,Neutral,0.25955113515113265,,0.36999945849974963,0.81238,,0.6113803008711397,,0.7118801504355698,,Neutral,,Neutral,,0.16510046833892764,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.2511,1.8853,-22.2096,-3.99777403960999,0.0245698465096838,Benign,0.8244,pathogenic,-3.482,available,https://doi.org/10.1101/2022.10.22.513328 +R156P,NP_000537:p.Arg156Pro,"hg19,17:g.7578463C>G, hg19,17:g.7675145C>G, hg38,17:g.7675145C>G",,,0.609,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634768,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,2.98159,2.535810236930847,3.1345799999999997,4.422155802019631,3.058085,3.701872901009816,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.46597466307429164,1.8235646087996626,0.40167335709959473,3.75729,4.439453333333334,2.7587195051026687,4.098371666666667,3.2580047525513343,Destabilizing,Uncertain,Destabilizing,Destabilizing,2.1939482846735983,0.9723714760027401,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.3783,1.8853,-22.2096,-4.67495615038927,0.0728951347826166,Benign,0.9793,pathogenic,-3.644,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R156Q,NP_000537:p.Arg156Gln,,,,,saturation_mutlist,,,,,,,,0.80834,0.8768375825881958,,1.0848008901585893,,0.9465704450792947,,Neutral,Neutral,,Neutral,0.3563633272889377,,0.1814654342352296,0.25478,,0.7332495605623107,,0.49401478028115536,,Neutral,,Neutral,,0.03902438786245789,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.211,1.8853,-22.2096,-3.27661061520608,0.0007299895989928,Benign,0.1429,benign,-3.218,available,https://doi.org/10.1101/2022.10.22.513328 +R156S,NP_000537:p.Arg156Ser,"hg19,17:g.7578464G>T, hg38,17:g.7675146G>T",,,0.523,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1742298,Uncertain significance,1,,,,,1.92011,1.1240950918197632,1.0274366666666668,1.6294264434674595,1.4737733333333334,1.7747682217337297,Neutral,Neutral,Uncertain,Neutral,Neutral,0.28945281019604086,0.16196340663523007,0.15817016055426106,1.2846,1.5998866666666667,1.0639567768582487,1.4422433333333333,1.1742783884291244,Neutral,Neutral,Neutral,Neutral,0.3849676991933508,0.1347700209294016,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.169,1.8853,-8.9217,-2.74605685958695,0.0038579046441381,Benign,0.6905,pathogenic,-3.33,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R156T,NP_000537:p.Arg156Thr,,,,,saturation_mutlist,,,,,,,,1.68393,0.7014709508419037,,1.2838272739907415,,1.4838786369953707,,Neutral,Neutral,,Neutral,0.2689443404353727,,0.27382954100856116,0.73811,,0.6508228280126055,,0.6944664140063028,,Neutral,,Neutral,,0.0805698512939448,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.2411,1.8853,-22.2096,-1.82458859592878,0.001184489018864,Benign,0.4236,ambiguous,-3.285,available,https://doi.org/10.1101/2022.10.22.513328 +R156V,NP_000537:p.Arg156Val,,,,,saturation_mutlist,,,,,,,,0.59694,0.3322271466255188,,0.5932255072565639,,0.5950827536282819,,Neutral,Neutral,,Neutral,0.27125176789422445,,0.3335047249026763,0.15884,,0.04312102998184907,,0.10098051499092454,,Neutral,,Neutral,,0.08585447634219988,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.1432,1.8853,-0.737,-0.821931873321886,1.965324480471501e-09,Benign,0.3593,ambiguous,-2.918,available,https://doi.org/10.1101/2022.10.22.513328 +R156W,NP_000537:p.Arg156Trp,,,,,saturation_mutlist,,,,,,,,0.89702,0.21927471160888673,,0.10879102929028496,,0.5029055146451425,,Neutral,Neutral,,Neutral,0.4963814549136351,,0.15498064988323582,0.11572,,-0.2309597138348891,,-0.057619856917444555,,Neutral,,Neutral,,0.08800476241239015,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.254,1.8853,-22.2096,-3.07237716340324,0.0137224585611587,Benign,0.2709,benign,-3.562,available,https://doi.org/10.1101/2022.10.22.513328 +R156Y,NP_000537:p.Arg156Tyr,,,,,saturation_mutlist,,,,,,,,0.67242,0.24999971628189088,,0.33154571152028356,,0.5019828557601418,,Neutral,Neutral,,Neutral,0.4062767186666557,,0.08272815462792048,-0.1231,,0.15952173954500454,,0.018210869772502268,,Neutral,,Neutral,,0.12097358672375415,28.475,6.204,48.855,7.856,,False,28.475,,neutral,neutral,neutral,,False,48.855,,neutral,neutral,neutral,uncertain,,-0.2577,1.8853,-22.2096,-2.68529061448795,0.0001505148817471,Benign,0.4762,ambiguous,-3.375,available,https://doi.org/10.1101/2022.10.22.513328 +V157A,NP_000537:p.Val157Ala,"hg19,17:g.7578460A>G, hg38,17:g.7675142A>G",,,0.848,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428887,Conflicting classifications of pathogenicity,1,,,,,3.12431,2.089348387718201,2.9853733333333334,2.9127212278866548,3.0548416666666665,3.018515613943327,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.20540874789440333,0.23047346591069628,0.03319185518540168,1.62747,2.42823,2.2443479948885767,2.02785,1.9359089974442885,Uncertain,Uncertain,Uncertain,Neutral,0.18292164952970075,0.12260947690863408,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.2201,1.4207,-22.2096,-6.03177136945862,0.8506491824178575,Pathogenic,0.9464,pathogenic,-4.026,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157C,NP_000537:p.Val157Cys,,,,,saturation_mutlist,,,,,,,,2.18812,1.2629429531097411,,2.7389252378852524,,2.4635226189426263,,Uncertain,Uncertain,,Uncertain,0.18414024820340938,,0.00964177751242438,1.36626,,2.3728283119939735,,1.8695441559969868,,Uncertain,,Neutral,,0.2582741561539069,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.248,1.4207,-22.2096,-6.03177136945862,0.8340472145442,Pathogenic,0.9744,pathogenic,-4.118,available,https://doi.org/10.1101/2022.10.22.513328 +V157D,NP_000537:p.Val157Asp,"hg19,17:g.7578460A>T, hg19,17:g.7675142A>T, hg38,17:g.7675142A>T",,,0.863,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",482231,Conflicting classifications of pathogenicity,1,,,,,3.35087,3.276381015777588,4.157936666666667,4.284753869681277,3.7544033333333333,3.8178119348406385,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.17390474853298,0.49687737255338527,0.3689788736804985,3.82497,4.07812,3.454388592263159,3.9515450000000003,3.63967929613158,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.424049771371239,0.2960789065362937,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.3867,1.4207,-22.2096,-6.54106190246927,0.8343084508991363,Pathogenic,0.9992,pathogenic,-4.568,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157E,NP_000537:p.Val157Glu,"hg38,17:g.7675141_7675142delinsTT",,,,"COSMIC,saturation_mutlist",,,,,,,,3.02531,3.118176155090332,3.9150799999999997,4.1550240130481235,3.470195,3.590167006524062,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.205514090328384,0.11946619856679128,0.2724923072577248,3.91019,3.6478466666666662,2.926092470505147,3.779018333333333,3.4181412352525733,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.16965704275259413,0.3455490158133955,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,uncertain,,-0.344,1.4207,-22.2096,-6.54106190246927,0.8255579501020398,Pathogenic,0.9966,pathogenic,-4.515,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157F,NP_000537:p.Val157Phe,"hg19,17:g.7578461C>A, hg19,17:g.7675143C>A, hg38,17:g.7675143C>A, hg38,17:g.7675143_7675144delinsAA, hg38,17:g.7675143_7675144delinsAT",,,0.708,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12353,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,2.62893,1.2094540119171142,3.7871900000000003,1.873670789500138,3.20806,2.251300394750069,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.4442330527638171,1.4851241859858053,0.5413203947114018,3.66326,0.2192733333333333,0.10971114000000788,1.9412666666666667,1.886485570000004,Uncertain,Uncertain,Neutral,Neutral,1.2086694689156703,0.5754185064955387,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.2214,1.4207,-7.3368,-3.18514303664848,0.8019161184297998,Pathogenic,0.9349,pathogenic,-4.016,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157G,NP_000537:p.Val157Gly,"hg19,17:g.7578459_7578460delinsAC, hg19,17:g.7578460A>C, hg19,17:g.7675142A>C, hg38,17:g.7675141_7675142delinsAC, hg38,17:g.7675142A>C",,,0.872,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","3148383, 915695","Likely pathogenic, Pathogenic/Likely pathogenic","1, 2",,,Tier I - Strong,1,4.4681,2.9586009883880617,5.599543333333334,4.968091602625364,5.033821666666666,4.718095801312682,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.1551713689913388,0.4265691538569358,0.3644925011929364,2.53686,4.812016666666666,4.1426953921294,3.674438333333333,3.3397776960647,Uncertain,Uncertain,Destabilizing,Destabilizing,0.19486383234339688,0.15388573185724813,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.3459,1.4207,-22.2096,-6.54106190246927,0.7995863355789101,Pathogenic,0.9524,pathogenic,-4.427,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157H,NP_000537:p.Val157His,,,,,saturation_mutlist,,,,,,,,4.25462,2.744153699874878,,2.860155351062673,,3.5573876755313365,,Uncertain,Destabilizing,,Destabilizing,0.31638497386005415,,0.4785293967016609,4.842,,1.4293951281495276,,3.1356975640747637,,Uncertain,,Destabilizing,,0.31387782090237215,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.3897,1.4207,-22.2096,-5.9252980949022,0.8362842528324033,Pathogenic,0.9988,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328 +V157I,NP_000537:p.Val157Ile,"hg19,17:g.7578461C>T, hg38,17:g.7675143C>T",,3.97921259341e-05,0.425,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",185404,Likely benign,3,,,,,-0.98498,-0.30687042236328127,-0.12812,0.36870228978155933,-0.55655,-0.30813885510922034,Neutral,Neutral,Neutral,Neutral,Neutral,0.10192770875758148,0.4829010918052129,0.22593367583810317,-0.31561,0.27891,0.38459401515223846,-0.018350000000000005,0.03449200757611923,Neutral,Neutral,Neutral,Neutral,0.504591475420133,0.5349704978268569,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.0461,1.4207,-0.737,-0.27683081420522,4.169943083037448e-08,Benign,0.1052,benign,-2.904,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157K,NP_000537:p.Val157Lys,,,,,saturation_mutlist,,,,,,,,3.30406,2.8832352638244627,,5.224027587366884,,4.2640437936834426,,Destabilizing,Destabilizing,,Destabilizing,0.2433884959042205,,0.6118735452560078,3.59327,,3.355399494479921,,3.4743347472399604,,Destabilizing,,Destabilizing,,0.19631221179706068,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.383,1.4207,-22.2096,-6.54106190246927,0.8337409124340375,Pathogenic,0.9971,pathogenic,-4.538,available,https://doi.org/10.1101/2022.10.22.513328 +V157L,NP_000537:p.Val157Leu,"hg19,17:g.7578461C>G, hg19,17:g.7675143C>G, hg38,17:g.7675143C>G",,,0.546,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1515529,Uncertain significance,1,,,,,-0.37936,0.5230686378479004,1.5302699999999998,0.7921182700373212,0.5754549999999999,0.2063791350186606,Neutral,Neutral,Neutral,Neutral,Neutral,0.24218708541827524,0.38200563250646785,0.31318680905073776,0.48924,1.2571433333333333,0.14761516054406087,0.8731916666666666,0.31842758027203044,Neutral,Neutral,Neutral,Neutral,0.730350058594431,0.3396684726922862,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.1216,1.4207,-2.7926,-1.65744017387142,2.1357464196808862e-06,Benign,0.6073,pathogenic,-3.005,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157M,NP_000537:p.Val157Met,,,,,saturation_mutlist,,,,,,,,-0.33065,1.3782098197937012,,1.6849955703165795,,0.6771727851582898,,Neutral,Uncertain,,Neutral,0.2751325960619877,,0.3535022038542504,0.40174,,0.7232350484724493,,0.5624875242362246,,Neutral,,Neutral,,0.26008326434808277,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.2298,1.4207,-22.2096,-3.92629450142789,0.7838199736330359,Pathogenic,0.856,pathogenic,-4.016,available,https://doi.org/10.1101/2022.10.22.513328 +V157N,NP_000537:p.Val157Asn,,,,,saturation_mutlist,,,,,,,,2.54306,3.074934234619141,,2.7749659758597773,,2.6590129879298887,,Uncertain,Destabilizing,,Uncertain,0.2202050317383451,,0.22522776860776417,2.74718,,2.308259367581712,,2.527719683790856,,Uncertain,,Uncertain,,0.21968270680147292,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.3746,1.4207,-22.2096,-6.54106190246927,0.7447682330697962,Pathogenic,0.997,pathogenic,-4.464,available,https://doi.org/10.1101/2022.10.22.513328 +V157P,NP_000537:p.Val157Pro,,,,,saturation_mutlist,,,,,,,,4.32497,3.0001340389251707,,5.778415223564818,,5.051692611782409,,Destabilizing,Destabilizing,,Destabilizing,0.14743846033536906,,0.4342247934485222,3.12504,,5.931564789541284,,4.528302394770642,,Destabilizing,,Destabilizing,,0.3787767626973703,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.4244,1.4207,-22.2096,-6.54106190246927,0.823675674972593,Pathogenic,0.9948,pathogenic,-4.258,available,https://doi.org/10.1101/2022.10.22.513328 +V157Q,NP_000537:p.Val157Gln,,,,,saturation_mutlist,,,,,,,,2.72531,3.040139636993408,,3.0503766877956244,,2.887843343897812,,Uncertain,Destabilizing,,Uncertain,0.2739728067031197,,0.2548340311711648,2.77598,,2.125150466245362,,2.4505652331226813,,Uncertain,,Uncertain,,0.20199249649159143,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,uncertain,,-0.3546,1.4207,-22.2096,-6.54106190246927,0.8315062836184418,Pathogenic,0.9957,pathogenic,-4.419,available,https://doi.org/10.1101/2022.10.22.513328 +V157R,NP_000537:p.Val157Arg,,,,,saturation_mutlist,,,,,,,,4.23764,2.8449759006500246,,4.160331678117049,,4.198985839058524,,Destabilizing,Destabilizing,,Destabilizing,0.23185490160259745,,0.6593063820337527,5.78932,,2.165278790192159,,3.9772993950960798,,Uncertain,,Destabilizing,,0.16742871467968867,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.404,1.4207,-22.2096,-6.54106190246927,0.8271034459001179,Pathogenic,0.9941,pathogenic,-4.37,available,https://doi.org/10.1101/2022.10.22.513328 +V157S,NP_000537:p.Val157Ser,,,,,saturation_mutlist,,,,,,,,4.00218,2.8983062744140624,,3.8380660705814207,,3.92012303529071,,Destabilizing,Destabilizing,,Destabilizing,0.21864428674079783,,0.20912271048869496,2.59565,,3.1207005852382586,,2.858175292619129,,Uncertain,,Uncertain,,0.32470124798807415,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.3238,1.4207,-22.2096,-6.03177136945862,0.8303028750561633,Pathogenic,0.9901,pathogenic,-4.244,available,https://doi.org/10.1101/2022.10.22.513328 +V157T,NP_000537:p.Val157Thr,,,,,saturation_mutlist,,,,,,,,2.22163,2.1150920963287354,,2.3946732384399096,,2.308151619219955,,Uncertain,Destabilizing,,Uncertain,0.17888554556998393,,0.08379376584946575,1.6243,,2.0308276868248543,,1.827563843412427,,Uncertain,,Neutral,,0.3071740320647533,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.1662,1.4207,-7.9218,-4.43536378738608,0.7963706965341553,Pathogenic,0.9748,pathogenic,-4.09,available,https://doi.org/10.1101/2022.10.22.513328 +V157W,NP_000537:p.Val157Trp,,,,,saturation_mutlist,,,,,,,,7.84414,1.6351368856430053,,3.355097574633568,,5.599618787316784,,Destabilizing,Uncertain,,Destabilizing,0.44506498979612263,,0.7730002418645208,10.0141,,0.4941101964233765,,5.254105098211688,,Uncertain,,Destabilizing,,0.7220145155471944,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.3378,1.4207,-22.2096,-5.9252980949022,0.8090995667678536,Pathogenic,0.9983,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328 +V157Y,NP_000537:p.Val157Tyr,,,,,saturation_mutlist,,,,,,,,4.60467,1.5695085430145264,,2.9674976511320814,,3.7860838255660405,,Uncertain,Uncertain,,Destabilizing,0.4597908993037276,,0.6640215408107883,5.64618,,0.6784339249327717,,3.1623069624663858,,Uncertain,,Destabilizing,,0.7845042942944823,0.549,0.852,3.995,2.771,,False,0.549,,neutral,neutral,neutral,,False,3.995,,neutral,neutral,neutral,neutral,,-0.3407,1.4207,-22.2096,-5.9252980949022,0.8193908616849128,Pathogenic,0.9927,pathogenic,-4.37,available,https://doi.org/10.1101/2022.10.22.513328 +R158A,NP_000537:p.Arg158Ala,,,,,saturation_mutlist,,,,,,,,1.4096,1.2469738817214966,,1.4311894506355678,,1.420394725317784,,Neutral,Uncertain,,Neutral,0.369226361165942,,0.158948161637514,0.63386,,1.5737716430899826,,1.1038158215449914,,Neutral,,Neutral,,0.23738134667747002,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.4001,0.1043,-22.2096,-7.1028394778161,0.8050741506879635,Pathogenic,0.9977,pathogenic,-4.342,available,https://doi.org/10.1101/2022.10.22.513328 +R158C,NP_000537:p.Arg158Cys,"hg19,17:g.7578458G>A, hg19,17:g.7578458_7578459delinsAA, hg19,17:g.7675140G>A, hg38,17:g.7675138_7675140delinsACA, hg38,17:g.7675140G>A, hg38,17:g.7675140_7675141delinsAA",,7.9593753482e-06,0.835,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127812,Uncertain significance,3,,,,,1.04437,0.6130520558357239,1.5507966666666666,1.872877568921756,1.2975833333333333,1.458623784460878,Neutral,Neutral,Neutral,Neutral,Neutral,0.3667747473755992,0.2842750731636917,0.2372602020442286,0.40408,0.4248333333333334,1.8492347115651089,0.4144566666666667,1.1266573557825543,Neutral,Neutral,Neutral,Neutral,0.6744678229208237,0.21151083957099642,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.409,0.1043,-22.2096,-6.77998842762731,0.0402279186236466,Benign,0.9622,pathogenic,-3.874,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158D,NP_000537:p.Arg158Asp,,,,,saturation_mutlist,,,,,,,,2.50967,2.5440502977371215,,2.839091187282092,,2.674380593641046,,Uncertain,Destabilizing,,Uncertain,0.3639151291134499,,0.3742601718365477,3.30598,,2.3599070401212754,,2.8329435200606374,,Uncertain,,Uncertain,,0.3620476483882345,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.4912,0.1043,-22.2096,-7.8974356797228,0.7960539498923963,Pathogenic,0.9994,pathogenic,-4.604,available,https://doi.org/10.1101/2022.10.22.513328 +R158E,NP_000537:p.Arg158Glu,,,,,saturation_mutlist,,,,,,,,1.88759,1.8958616542816162,,2.321596343176914,,2.104593171588457,,Uncertain,Uncertain,,Uncertain,0.4268699355348396,,0.4331804938902315,1.69072,,1.9009425564277604,,1.7958312782138801,,Neutral,,Neutral,,0.3499096715084132,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.4364,0.1043,-22.2096,-7.8974356797228,0.8383647753557675,Pathogenic,0.9952,pathogenic,-4.456,available,https://doi.org/10.1101/2022.10.22.513328 +R158F,NP_000537:p.Arg158Phe,"hg19,17:g.7578456_7578458delinsAAA, hg19,17:g.7578457_7578458delinsAA, hg38,17:g.7675139_7675140delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,3.1097,0.46758891820907594,0.5792533333333333,0.6539340826774592,1.8444766666666668,1.8818170413387296,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.29949475973744083,0.8568546323359381,0.5115616563948839,4.51811,-0.035486666666666666,0.5412478363317129,2.241311666666667,2.5296789181658563,Uncertain,Uncertain,Uncertain,Uncertain,0.3485929753866089,0.25726770618038475,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.4323,0.1043,-22.2096,-6.94790315070581,0.6834057698841777,Pathogenic,0.9992,pathogenic,-4.331,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158G,NP_000537:p.Arg158Gly,"hg19,17:g.7578458G>C, hg19,17:g.7675140G>C, hg38,17:g.7675140G>C",,,0.862,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",856171,Pathogenic,2,,,Tier I - Strong,1,2.61947,2.2245520544052124,3.4168966666666667,3.0472127381893084,3.0181833333333334,2.8333413690946543,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,0.36651621496060693,0.07760324062534724,0.1590064673406942,1.77562,2.7452400000000003,2.93429617705621,2.2604300000000004,2.3549580885281047,Uncertain,Uncertain,Uncertain,Uncertain,0.3997806054158537,0.36798237185933097,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.4355,0.1043,-22.2096,-7.8974356797228,0.7385355247444985,Pathogenic,0.9963,pathogenic,-4.418,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158H,NP_000537:p.Arg158His,"hg19,17:g.7578457C>T, hg19,17:g.7675139C>T, hg38,17:g.7675139C>T",,3.9798143815e-06,0.844,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141963,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,3.18564,1.1035969352722168,1.6783466666666669,1.2782683754602269,2.4319933333333332,2.2319541877301132,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.32368099770116504,0.5914557427417728,0.3586068212447856,5.08948,0.75,1.0928795577054566,2.91974,3.0911797788527284,Uncertain,Uncertain,Uncertain,Destabilizing,0.3778740118963815,0.2465672851468756,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.2902,0.1043,-6.5999,-4.0144422087353,0.001325604384502,Benign,0.9236,pathogenic,-3.528,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158I,NP_000537:p.Arg158Ile,"hg19,17:g.7578456_7578458delinsAAT, hg38,17:g.7675138_7675140delinsAAT",,,,"ClinVar,saturation_mutlist",958850,Uncertain significance,1,,,,,-0.34355,-0.3895813703536987,0.37970333333333334,0.1849204039834855,0.018076666666666658,-0.07931479800825726,Neutral,Neutral,Neutral,Neutral,Neutral,0.36920237017294066,0.2656471587567907,0.43294513353772657,-0.49001,-1.0031733333333333,0.6662480219311051,-0.7465916666666667,0.08811901096555255,Neutral,Neutral,Neutral,Neutral,1.2169692248185882,0.35908446281965095,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.4295,0.1043,-22.2096,-7.28243726462348,0.796711831584717,Pathogenic,0.9971,pathogenic,-4.418,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158K,NP_000537:p.Arg158Lys,,,,,saturation_mutlist,,,,,,,,0.33581,0.43379794716835024,,1.7292190942253463,,1.032514547112673,,Neutral,Neutral,,Neutral,0.07393226126018053,,0.2295400359508381,0.03121,,1.3082668398983344,,0.6697384199491672,,Neutral,,Neutral,,0.12114947398910765,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,uncertain,,-0.2226,0.1043,-8.9217,-2.91084196007257,0.0429422234378775,Benign,0.9285,pathogenic,-3.656,available,https://doi.org/10.1101/2022.10.22.513328 +R158L,NP_000537:p.Arg158Leu,"hg19,17:g.7578456_7578457delinsAA, hg19,17:g.7578457C>A, hg19,17:g.7675139C>A, hg38,17:g.7675138_7675139delinsAA, hg38,17:g.7675139C>A",,3.9798143815e-06,0.891,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","568285, 528248","Pathogenic/Likely pathogenic, Pathogenic","2, 3",,,Tier I - Strong,1,-0.35477,0.49963741302490233,0.48197666666666666,0.07098524049689993,0.06360333333333335,-0.14189237975155003,Neutral,Neutral,Neutral,Neutral,Neutral,0.3204786865832532,0.2955910876344023,0.21140756249024728,-0.78806,-0.83095,0.3662084536721147,-0.8095049999999999,-0.21092577316394265,Neutral,Neutral,Neutral,Neutral,0.5907866210965399,0.15529708887055207,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,neutral,-0.4026,0.1043,-22.2096,-7.28243726462348,0.6435048833731373,Uncertain,0.9902,pathogenic,-4.204,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158M,NP_000537:p.Arg158Met,,,,,saturation_mutlist,,,,,,,,-0.40333,0.5961823225021362,,0.6479109073006909,,0.12229045365034544,,Neutral,Neutral,,Neutral,0.2900374434413787,,0.108768298392906,-1.11536,,0.9840239493859081,,-0.06566802530704591,,Neutral,,Neutral,,0.2353763144194958,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.3684,0.1043,-22.2096,-7.28243726462348,0.7715392029099782,Pathogenic,0.9989,pathogenic,-4.373,available,https://doi.org/10.1101/2022.10.22.513328 +R158N,NP_000537:p.Arg158Asn,,,,,saturation_mutlist,,,,,,,,1.51751,1.665932641029358,,1.7280081269957623,,1.622759063497881,,Neutral,Uncertain,,Neutral,0.30322565531613166,,0.30239676843480173,1.3414,,1.5529110854608865,,1.4471555427304432,,Neutral,,Neutral,,0.25216647859892405,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.415,0.1043,-22.2096,-7.8974356797228,0.8354581091440914,Pathogenic,0.9989,pathogenic,-4.331,available,https://doi.org/10.1101/2022.10.22.513328 +R158P,NP_000537:p.Arg158Pro,"hg19,17:g.7578456_7578457delinsAG, hg19,17:g.7578457C>G, hg19,17:g.7578457_7578459delinsGGA, hg19,17:g.7675139C>G, hg38,17:g.7675139C>G",,,0.916,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",246118,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,4.28128,2.550253782272339,2.6145133333333335,5.336550437513632,3.447896666666667,4.808915218756816,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.295001297248631,0.3355119813392991,0.33070555658393885,5.39146,3.1451233333333337,4.745185674300916,4.268291666666667,5.068322837150458,Destabilizing,Destabilizing,Destabilizing,Destabilizing,1.122287630551495,1.282599906091461,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.5422,0.1043,-22.2096,-7.8974356797228,0.7643157860762336,Pathogenic,0.9986,pathogenic,-4.48,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158Q,NP_000537:p.Arg158Gln,,,,,saturation_mutlist,,,,,,,,1.07217,1.2213736736774445,,1.5674746767348078,,1.319822338367404,,Neutral,Uncertain,,Neutral,0.28580654471836014,,0.1803089471217079,0.33282,,1.6759919852046556,,1.0044059926023279,,Neutral,,Neutral,,0.22781382139905923,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.3748,0.1043,-22.2096,-7.8974356797228,0.7280116113949682,Pathogenic,0.9552,pathogenic,-4.004,available,https://doi.org/10.1101/2022.10.22.513328 +R158S,NP_000537:p.Arg158Ser,"hg19,17:g.7578458G>T, hg19,17:g.7675140G>T, hg38,17:g.7675140G>T",,,0.864,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1067910,Pathogenic,1,,,Tier I - Strong,1,1.933,1.1321544682979583,2.2210866666666664,2.226566480608561,2.077043333333333,2.0797832403042804,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.3494867518069055,0.20493621273188614,0.1133771539264119,1.03652,1.31417,1.938021932503581,1.175345,1.4872709662517907,Neutral,Neutral,Neutral,Neutral,0.6112167597505814,0.26996758649951896,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.4007,0.1043,-22.2096,-7.1028394778161,0.3648532772081086,Uncertain,0.9981,pathogenic,-4.09,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158T,NP_000537:p.Arg158Thr,,,,,saturation_mutlist,,,,,,,,1.07598,0.5507839012145996,,1.4556389586183078,,1.2658094793091539,,Neutral,Neutral,,Neutral,0.3447510224245778,,0.2467667540565322,0.76387,,1.5747070556487166,,1.1692885278243583,,Neutral,,Neutral,,0.23381173724820653,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.405,0.1043,-22.2096,-7.1028394778161,0.8311202221216565,Pathogenic,0.9979,pathogenic,-4.126,available,https://doi.org/10.1101/2022.10.22.513328 +R158V,NP_000537:p.Arg158Val,,,,,saturation_mutlist,,,,,,,,-0.22565,-0.25703929901123046,,0.33669586182160893,,0.05552293091080447,,Neutral,Neutral,,Neutral,0.33731267929883785,,0.4370447123776918,-0.23271,,0.7590460549113521,,0.2631680274556761,,Neutral,,Neutral,,0.2752973830164895,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.4166,0.1043,-22.2096,-6.70684669011845,0.4215891016473184,Uncertain,0.9953,pathogenic,-4.059,available,https://doi.org/10.1101/2022.10.22.513328 +R158W,NP_000537:p.Arg158Trp,,,,,saturation_mutlist,,,,,,,,2.88634,0.7027670764923095,,0.6158115232276606,,1.7510757616138304,,Uncertain,Neutral,,Neutral,0.37798868703241756,,0.375961287918023,5.32529,,0.5887439411372596,,2.9570169705686298,,Uncertain,,Uncertain,,0.37610401458297243,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.4179,0.1043,-22.2096,-6.94790315070581,0.7744905473454666,Pathogenic,0.9826,pathogenic,-4.356,available,https://doi.org/10.1101/2022.10.22.513328 +R158Y,NP_000537:p.Arg158Tyr,,,,,saturation_mutlist,,,,,,,,3.30784,0.5109761309623718,,0.9806586828968623,,2.144249341448431,,Uncertain,Neutral,,Uncertain,0.33039461407292303,,0.4596096065055258,5.89344,,0.7026257111836794,,3.2980328555918397,,Uncertain,,Destabilizing,,0.26148352045360895,23.245,5.646,23.425,8.171,,False,23.245,,neutral,neutral,neutral,,False,23.425,,neutral,neutral,neutral,damaging,,-0.4216,0.1043,-22.2096,-6.94790315070581,0.7780450112465993,Pathogenic,0.9961,pathogenic,-4.408,available,https://doi.org/10.1101/2022.10.22.513328 +A159C,NP_000537:p.Ala159Cys,,,,,saturation_mutlist,,,,,,,,0.06036,-0.9932851648330688,,0.9832826526641506,,0.5218213263320753,,Neutral,Neutral,,Neutral,0.11153476333926737,,0.21574230267867578,0.66431,,0.905080082579406,,0.7846950412897029,,Neutral,,Neutral,,0.23400696761351217,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3172,0.2526,-22.2096,-3.75335838591384,0.3050808316386852,Benign,0.7688,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328 +A159D,NP_000537:p.Ala159Asp,"hg19,17:g.7578454G>T, hg19,17:g.7675136G>T, hg38,17:g.7675136G>T",,,0.836,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1026335,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,2.63296,2.1063504314422605,2.8628133333333334,2.7277033921449108,2.747886666666667,2.6803316960724555,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,0.35940518779291436,0.6181190718264205,0.07654372490899707,3.73302,2.6356,2.2264964082563523,3.18431,2.979758204128176,Uncertain,Uncertain,Destabilizing,Uncertain,0.5322436207226913,0.034923156324907924,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3989,0.2526,-22.2096,-7.56118054309627,0.7783769042694721,Pathogenic,0.9985,pathogenic,-4.448,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159E,NP_000537:p.Ala159Glu,,,,,saturation_mutlist,,,,,,,,2.18122,1.6030721879005432,,3.062687988392053,,2.6219539941960264,,Uncertain,Uncertain,,Uncertain,0.35152065863254156,,0.36764209659496855,3.8446,,2.0481415120533706,,2.946370756026685,,Uncertain,,Uncertain,,0.31541747001753717,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3846,0.2526,-22.2096,-7.56118054309627,0.7696593704216773,Pathogenic,0.9976,pathogenic,-4.44,available,https://doi.org/10.1101/2022.10.22.513328 +A159F,NP_000537:p.Ala159Phe,"hg19,17:g.7578454_7578455delinsAA, hg38,17:g.7675136_7675137delinsAA",,,,"ClinVar,saturation_mutlist",182961,Uncertain significance,1,,,,,6.98837,-1.3415327763557434,1.40714,1.8354646109090773,4.197755,4.411917305454539,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.5583206809616523,0.973248769534285,0.8723050375590274,8.37902,4.198413333333334,-0.6722122341377091,6.288716666666668,3.8534038829311457,Destabilizing,Uncertain,Destabilizing,Destabilizing,2.9778471983670047,0.7255820213699286,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3673,0.2526,-22.2096,-7.56118054309627,0.756637955227241,Pathogenic,0.979,pathogenic,-4.203,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159G,NP_000537:p.Ala159Gly,,,,,saturation_mutlist,,,,,,,,1.88394,0.9839895844459534,,2.460551118617259,,2.1722455593086294,,Uncertain,Neutral,,Uncertain,0.20905242903289914,,0.5964093289080705,0.69272,,2.653486872464675,,1.6731034362323376,,Uncertain,,Neutral,,0.3540446382218718,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,neutral,,-0.3107,0.2526,-22.2096,-5.92587399176263,0.0737808386571025,Benign,0.5551,ambiguous,-3.672,available,https://doi.org/10.1101/2022.10.22.513328 +A159H,NP_000537:p.Ala159His,,,,,saturation_mutlist,,,,,,,,7.29849,1.0857284843921662,,2.430065168575218,,4.864277584287609,,Uncertain,Uncertain,,Destabilizing,0.25295841322508295,,0.7415187625761703,8.83562,,0.3440012263164449,,4.589810613158223,,Uncertain,,Destabilizing,,0.4111222782170539,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3036,0.2526,-8.9217,-7.56118054309627,0.4037162014164137,Uncertain,0.9973,pathogenic,-4.184,available,https://doi.org/10.1101/2022.10.22.513328 +A159I,NP_000537:p.Ala159Ile,"hg19,17:g.7578454_7578455delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,-0.89094,-2.2210981941223142,0.41406000000000004,0.38261360138439793,-0.23843999999999996,-0.254163199307801,Neutral,Neutral,Stabilizing,Neutral,Neutral,0.34264671743635056,1.9913118362694142,0.6889480290777987,1.43518,0.8628133333333333,-0.1711626697660826,1.1489966666666667,0.6320086651169586,Neutral,Neutral,Neutral,Neutral,2.032505446919037,0.5551597740699413,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3568,0.2526,-22.2096,-4.90453163501885,0.0157143104023936,Benign,0.9256,pathogenic,-3.786,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159K,NP_000537:p.Ala159Lys,,,,,saturation_mutlist,,,,,,,,4.40269,1.301975884437561,,4.476931475590529,,4.4398107377952645,,Destabilizing,Uncertain,,Destabilizing,0.33692812268367206,,0.509838160256792,6.17946,,2.6849032789629272,,4.432181639481463,,Uncertain,,Destabilizing,,0.5952814849399887,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3892,0.2526,-22.2096,-7.56118054309627,0.7825933181932001,Pathogenic,0.9994,pathogenic,-4.595,available,https://doi.org/10.1101/2022.10.22.513328 +A159L,NP_000537:p.Ala159Leu,,,,,saturation_mutlist,,,,,,,,-0.35283,-1.3793712496757506,,0.5235061835743371,,0.08533809178716856,,Neutral,Uncertain,,Neutral,0.4735161733000319,,0.6805017636679973,0.86486,,-0.7439170532899225,,0.06047147335503872,,Neutral,,Neutral,,0.6766612997921971,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3616,0.2526,-22.2096,-5.96592803911561,0.0502942583274685,Benign,0.8367,pathogenic,-3.998,available,https://doi.org/10.1101/2022.10.22.513328 +A159M,NP_000537:p.Ala159Met,,,,,saturation_mutlist,,,,,,,,-0.57417,-1.1525927424430846,,1.02863564046649,,0.22723282023324504,,Neutral,Uncertain,,Neutral,0.4094607078592818,,0.44996987367969493,1.11185,,-0.47728537522572384,,0.3172823123871381,,Neutral,,Neutral,,0.5577632035012234,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3203,0.2526,-22.2096,-5.96592803911561,0.7734323157306574,Pathogenic,0.8932,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328 +A159N,NP_000537:p.Ala159Asn,,,,,saturation_mutlist,,,,,,,,1.97585,1.4441759943962098,,1.4168001297698316,,1.696325064884916,,Neutral,Uncertain,,Neutral,0.2988363708671479,,0.08649866423880032,2.50515,,0.8970746519965614,,1.7011123259982808,,Uncertain,,Neutral,,0.0795954594201438,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3015,0.2526,-8.9217,-7.56118054309627,0.7279914176699548,Pathogenic,0.9914,pathogenic,-4.402,available,https://doi.org/10.1101/2022.10.22.513328 +A159P,NP_000537:p.Ala159Pro,"hg19,17:g.7578455C>G, hg19,17:g.7675137C>G, hg38,17:g.7675137C>G",,,0.815,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182929,Conflicting classifications of pathogenicity,1,Oncogenic,2,,,1.95024,1.006061546728015,3.640133333333333,5.086201739312274,2.7951866666666665,3.518220869656137,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,0.4052709453741534,1.1668998031345945,0.5748298214033211,2.20598,3.0477333333333334,4.712699787685556,2.626856666666667,3.4593398938427775,Uncertain,Uncertain,Uncertain,Destabilizing,0.9700566065040857,0.5729233710056439,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.4387,0.2526,-22.2096,-7.56118054309627,0.7604955788970156,Pathogenic,0.9973,pathogenic,-4.248,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159Q,NP_000537:p.Ala159Gln,,,,,saturation_mutlist,,,,,,,,1.79388,1.2722301614284515,,1.9626053130718064,,1.8782426565359032,,Neutral,Uncertain,,Neutral,0.2923005311989017,,0.3337406325028012,3.62194,,0.8855736387010852,,2.2537568193505426,,Uncertain,,Uncertain,,0.3482070222191125,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3668,0.2526,-22.2096,-7.56118054309627,0.7759311807133028,Pathogenic,0.9938,pathogenic,-4.432,available,https://doi.org/10.1101/2022.10.22.513328 +A159R,NP_000537:p.Ala159Arg,,,,,saturation_mutlist,,,,,,,,8.53678,1.160092601776123,,3.205582912837778,,5.871181456418889,,Destabilizing,Uncertain,,Destabilizing,0.30935019983961426,,0.688726847765044,10.09165,,1.435186094869816,,5.763418047434908,,Uncertain,,Destabilizing,,0.6714333959657616,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3999,0.2526,-22.2096,-7.56118054309627,0.7621906723278383,Pathogenic,0.9967,pathogenic,-4.475,available,https://doi.org/10.1101/2022.10.22.513328 +A159S,NP_000537:p.Ala159Ser,"hg38,17:g.7675137C>A",,,0.727,"COSMIC,saturation_mutlist",,,,,,,,0.53467,0.8878367924690247,1.1418366666666666,1.3771088167150498,0.8382533333333333,0.9558894083575249,Neutral,Neutral,Neutral,Neutral,Neutral,0.18810185331656692,0.16264363525477682,0.4334980815389684,1.56651,1.6802733333333333,1.5561962620219802,1.6233916666666666,1.56135313101099,Neutral,Neutral,Neutral,Neutral,0.33321119192221343,0.38688947427663034,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.2819,0.2526,-22.2096,-3.62081775220914,0.0835691784716668,Benign,0.4783,ambiguous,-3.582,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159T,NP_000537:p.Ala159Thr,"hg19,17:g.7578455C>T, hg38,17:g.7675137C>T",,0.0,0.715,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1909172,Conflicting classifications of pathogenicity,1,,,,,-0.39666,0.29815258920192717,0.39592000000000005,0.7972183787202,-0.00036999999999998145,0.20027918936009997,Neutral,Neutral,Neutral,Neutral,Neutral,0.210625691448492,0.608629488167199,0.10590242953382452,2.17613,0.10680333333333332,0.8143647471759676,1.1414666666666666,1.4952473735879839,Uncertain,Uncertain,Neutral,Neutral,0.10318411290288615,0.14848219078494654,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.2006,0.2526,-5.1145,-0.819721990404372,3.507067245615645e-09,Benign,0.4315,ambiguous,-3.202,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159V,NP_000537:p.Ala159Val,"hg19,17:g.7578453_7578454delinsAA, hg19,17:g.7578454G>A, hg19,17:g.7675136G>A, hg38,17:g.7675135_7675136delinsAA, hg38,17:g.7675136G>A",,,0.774,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458545,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,-1.01486,-1.9201922225952148,-0.2678,-0.15088729836756373,-0.6413300000000001,-0.5828736491837819,Neutral,Neutral,Uncertain,Neutral,Neutral,0.24850578011638427,0.8145048142685632,0.4593608638550074,1.14669,-0.4955766666666666,-0.21370112885651646,0.3255566666666667,0.46649443557174175,Neutral,Neutral,Neutral,Neutral,1.2241393910099545,0.19907279607730102,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.2171,0.2526,-8.9217,-4.45460517452887,0.0025011567623869,Benign,0.6808,pathogenic,-3.412,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159W,NP_000537:p.Ala159Trp,,,,,saturation_mutlist,,,,,,,,13.475,-0.2232040810585022,,3.288762010226467,,8.381881005113232,,Destabilizing,Neutral,,Destabilizing,0.3143617883572413,,1.0484989201119386,16.26391,,-0.06244220191235228,,8.100733899043824,,Uncertain,,Destabilizing,,0.8271203206339576,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3782,0.2526,-22.2096,-7.56118054309627,0.6802380398553227,Pathogenic,0.999,pathogenic,-4.546,available,https://doi.org/10.1101/2022.10.22.513328 +A159Y,NP_000537:p.Ala159Tyr,,,,,saturation_mutlist,,,,,,,,9.77214,-0.1764132308959961,,2.791362732239259,,6.28175136611963,,Uncertain,Neutral,,Destabilizing,0.2734853170224865,,0.8722972680381265,9.94431,,0.017937915137202776,,4.9811239575686015,,Uncertain,,Destabilizing,,0.7368247648095881,0.309,0.504,6.605,6.839,,False,0.309,,neutral,neutral,neutral,,False,6.605,,neutral,neutral,neutral,uncertain,,-0.3865,0.2526,-22.2096,-7.56118054309627,0.7954557153601984,Pathogenic,0.9967,pathogenic,-4.441,available,https://doi.org/10.1101/2022.10.22.513328 +M160A,NP_000537:p.Met160Ala,,,,,saturation_mutlist,,,,,,,,1.991,1.0767398869991303,,1.7196504708887985,,1.8553252354443992,,Neutral,Uncertain,,Neutral,0.3444206341793681,,0.03873117009156832,1.9059,,1.232466939842778,,1.5691834699213891,,Neutral,,Neutral,,0.0615022655026153,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.319,0.8986,-22.2419,-4.77197012238704,0.2406404998338247,Benign,0.9231,pathogenic,-3.858,available,https://doi.org/10.1101/2022.10.22.513328 +M160C,NP_000537:p.Met160Cys,,,,,saturation_mutlist,,,,,,,,1.64573,0.0917027473449707,,1.9749350936624444,,1.8103325468312221,,Neutral,Neutral,,Neutral,0.18101578984829328,,0.06625172071470252,1.694,,1.5931072280602134,,1.6435536140301066,,Neutral,,Neutral,,0.12947276809028124,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.3245,0.8986,-22.2419,-4.94159724921602,0.830441929306543,Pathogenic,0.9567,pathogenic,-3.993,available,https://doi.org/10.1101/2022.10.22.513328 +M160D,NP_000537:p.Met160Asp,,,,,saturation_mutlist,,,,,,,,2.83227,1.1059154641628266,,2.3253775529633276,,2.5788237764816637,,Uncertain,Uncertain,,Uncertain,0.4384687731888768,,0.19024428867568632,2.05779,,1.889817381910121,,1.9738036909550605,,Uncertain,,Neutral,,0.17814569429075183,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.4305,0.8986,-22.2419,-6.3898967312866,0.8073356203134741,Pathogenic,0.9993,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328 +M160E,NP_000537:p.Met160Glu,,,,,saturation_mutlist,,,,,,,,1.82451,0.30941312074661254,,1.9173033029117288,,1.8709066514558645,,Neutral,Neutral,,Neutral,0.2924772265470674,,0.23549982922328425,1.16821,,1.4295708415238455,,1.2988904207619227,,Neutral,,Neutral,,0.06046940348540345,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.4207,0.8986,-22.2419,-6.3898967312866,0.495560462399917,Uncertain,0.9884,pathogenic,-4.227,available,https://doi.org/10.1101/2022.10.22.513328 +M160F,NP_000537:p.Met160Phe,,,,,saturation_mutlist,,,,,,,,1.0852,0.03642983198165894,,0.20258575775429755,,0.6438928788771487,,Neutral,Neutral,,Neutral,0.4284816475566248,,0.1721199045887844,2.48336,,-0.5460148931304846,,0.9686725534347576,,Uncertain,,Neutral,,0.32737657390615965,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.3241,0.8986,-22.2419,-6.56200410044584,0.7661135055131366,Pathogenic,0.9205,pathogenic,-4.014,available,https://doi.org/10.1101/2022.10.22.513328 +M160G,NP_000537:p.Met160Gly,,,,,saturation_mutlist,,,,,,,,2.53929,2.1404270696640015,,3.0021219035764077,,2.770705951788204,,Uncertain,Destabilizing,,Uncertain,0.4317093007551201,,0.17166940041522555,2.73962,,2.676148424377106,,2.707884212188553,,Uncertain,,Uncertain,,0.2026932498379099,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.327,0.8986,-7.9541,-4.11470891517805,0.2375769303336883,Benign,0.9861,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328 +M160H,NP_000537:p.Met160His,,,,,saturation_mutlist,,,,,,,,2.08432,1.1517130041122436,,1.1533935909495125,,1.6188567954747564,,Uncertain,Uncertain,,Neutral,0.3551811503073934,,0.22082548674515776,2.67449,,0.5641116310060142,,1.619300815503007,,Uncertain,,Neutral,,0.20400806563092658,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.3773,0.8986,-22.2419,-6.56200410044584,0.7557188852588048,Pathogenic,0.9933,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +M160I,NP_000537:p.Met160Ile,"hg19,17:g.7578450C>A, hg19,17:g.7578450C>G, hg19,17:g.7578450C>T, hg19,17:g.7675132C>A, hg38,17:g.7675132C>A, hg38,17:g.7675132C>G, hg38,17:g.7675132C>T",,1.19374477737e-05,"0.656, 0.657","cBioPortal,COSMIC,ClinVar,saturation_mutlist",230758,Likely benign,3,,,,,1.3069,0.08085883140563965,-0.5574833333333333,0.18396886698744716,0.3747083333333333,0.7454344334937235,Neutral,Neutral,Neutral,Neutral,Neutral,0.3111866789970214,0.27298681608377273,0.20632512038663714,0.34767,-0.038433333333333354,0.027791372434673833,0.1546183333333333,0.1877306862173369,Neutral,Neutral,Neutral,Neutral,0.4804376757591861,0.23368470509265205,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,uncertain,,-0.1634,0.8986,-7.9541,-1.85806821306715,0.0241597896788447,Benign,0.9318,pathogenic,-3.424,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160K,NP_000537:p.Met160Lys,"hg19,17:g.7578451A>T, hg38,17:g.7675133A>T",,,0.860,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.85417,1.9943678522109984,2.61803,1.8594941901073934,2.2361,1.8568320950536967,Uncertain,Neutral,Uncertain,Uncertain,Neutral,0.3891693923946916,1.0966255972147774,0.15612314503800115,2.38713,3.4688200000000005,1.2217906565490226,2.927975,1.8044603282745113,Uncertain,Uncertain,Uncertain,Neutral,0.5272575777233238,0.1794827595886252,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.3816,0.8986,-22.2419,-6.49813689004754,0.4216083122230772,Uncertain,0.9752,pathogenic,-4.028,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160L,NP_000537:p.Met160Leu,"hg19,17:g.7578452T>G, hg38,17:g.7675134T>G",,,0.569,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.31725,0.3933210039138794,-0.21632666666666667,0.07130161412799706,0.050461666666666655,0.19427580706399852,Neutral,Neutral,Neutral,Neutral,Neutral,0.16976266931845668,0.25127832806582334,0.11611628049404475,-0.04598,0.4956933333333333,-0.39015735029085336,0.22485666666666665,-0.2180686751454267,Neutral,Neutral,Neutral,Neutral,0.7263842638866994,0.16328898788148338,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,uncertain,,-0.1253,0.8986,-6.9542,-0.71506230071988,0.0089578048694624,Benign,0.4727,ambiguous,-3.342,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160N,NP_000537:p.Met160Asn,"hg19,17:g.7578450_7578451delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,2.47023,1.605393340587616,1.8820866666666667,1.752576450403864,2.1761583333333334,2.111403225201932,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.411119791515708,0.33933105578803463,0.02947746061641778,2.34954,2.320066666666667,1.239823866097966,2.3348033333333333,1.7946819330489832,Uncertain,Uncertain,Uncertain,Neutral,0.28177623064331664,0.15901081080563947,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.3721,0.8986,-22.2419,-6.3898967312866,0.8246781190807602,Pathogenic,0.9874,pathogenic,-4.28,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160P,NP_000537:p.Met160Pro,,,,,saturation_mutlist,,,,,,,,3.90606,2.830192985534668,,4.370442919846135,,4.138251459923067,,Destabilizing,Destabilizing,,Destabilizing,0.49235778375063993,,0.682599292120468,4.84893,,4.167638211966916,,4.508284105983458,,Destabilizing,,Destabilizing,,1.2170326700515717,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.49,0.8986,-22.2419,-6.9321485527439,0.7607710446302134,Pathogenic,0.9996,pathogenic,-4.461,available,https://doi.org/10.1101/2022.10.22.513328 +M160Q,NP_000537:p.Met160Gln,,,,,saturation_mutlist,,,,,,,,1.68994,0.9311154866218567,,1.548289450619885,,1.6191147253099425,,Neutral,Neutral,,Neutral,0.2447915373303072,,0.11302485332452276,1.63118,,0.9313261194749497,,1.281253059737475,,Neutral,,Neutral,,0.05997356291579936,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.3642,0.8986,-22.2419,-5.93922847820589,0.3415850343102615,Uncertain,0.9302,pathogenic,-3.95,available,https://doi.org/10.1101/2022.10.22.513328 +M160R,NP_000537:p.Met160Arg,"hg19,17:g.7578451A>C, hg38,17:g.7675133A>C",,,0.865,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.22534,1.7590256452560424,1.6514766666666665,1.2074880960325842,1.9384083333333333,1.7164140480162922,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.37147242612318737,0.9490517988088016,0.15970029100911573,3.18341,2.44093,0.6625310537861515,2.81217,1.9229705268930757,Uncertain,Uncertain,Uncertain,Neutral,0.3871239714441184,0.11664878018134549,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.4089,0.8986,-22.2419,-6.69861340466964,0.7302922830871812,Pathogenic,0.978,pathogenic,-3.957,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160S,NP_000537:p.Met160Ser,,,,,saturation_mutlist,,,,,,,,1.97465,1.0519418156147002,,2.248499000941131,,2.1115745004705655,,Uncertain,Uncertain,,Uncertain,0.3239205574495911,,0.12872262417728803,2.56843,,1.9544219660165598,,2.26142598300828,,Uncertain,,Uncertain,,0.28148890430589507,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.3504,0.8986,-22.2419,-4.77991809731783,0.4813826400138841,Uncertain,0.9369,pathogenic,-3.926,available,https://doi.org/10.1101/2022.10.22.513328 +M160T,NP_000537:p.Met160Thr,"hg19,17:g.7578451A>G, hg38,17:g.7675133A>G",,,0.669,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2915501,Uncertain significance,1,,,,,1.77028,0.7102491402626038,1.0341266666666666,1.4670476172330602,1.4022033333333335,1.6186638086165301,Neutral,Neutral,Neutral,Neutral,Neutral,0.31520737526929415,0.2879642494400226,0.1092562968333891,1.87332,0.7996599999999999,1.2589480812737313,1.33649,1.5661340406368658,Neutral,Neutral,Neutral,Neutral,0.5801778462391224,0.23100477599328656,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.1894,0.8986,-2.4948,-2.5259026466363,6.161701149059683e-06,Benign,0.5246,ambiguous,-3.189,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160V,NP_000537:p.Met160Val,"hg19,17:g.7578452T>C, hg38,17:g.7675134T>C",,3.979370941e-06,0.689,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",444396,Conflicting classifications of pathogenicity,1,,,,,1.64334,0.14683712244033814,-0.04047666666666666,0.47603665563208525,0.8014316666666667,1.0596883278160427,Neutral,Neutral,Neutral,Neutral,Neutral,0.32738864839496895,0.3095251712255761,0.21146545601069208,0.56812,0.5230166666666667,0.3048980526886422,0.5455683333333333,0.4365090263443211,Neutral,Neutral,Neutral,Neutral,0.4827980516622752,0.18776334189570593,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.1904,0.8986,-6.9542,-1.85792401129712,0.0001529524193019,Benign,0.2649,benign,-3.319,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160W,NP_000537:p.Met160Trp,,,,,saturation_mutlist,,,,,,,,2.48474,0.1254397463798523,,0.2652885071325522,,1.3750142535662762,,Uncertain,Neutral,,Neutral,0.4499245468265726,,0.10667399921970674,3.4472,,-0.601587838010941,,1.4228060809945295,,Uncertain,,Neutral,,0.31428134681505493,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.319,0.8986,-8.9541,-6.56200410044584,0.7911684008175226,Pathogenic,0.9944,pathogenic,-4.312,available,https://doi.org/10.1101/2022.10.22.513328 +M160Y,NP_000537:p.Met160Tyr,,,,,saturation_mutlist,,,,,,,,2.11056,0.2938493990898132,,0.519420720052028,,1.314990360026014,,Uncertain,Neutral,,Neutral,0.5415089696988515,,0.12281757374878856,3.60588,,-0.2233389869665059,,1.691270506516747,,Uncertain,,Neutral,,0.3397092691705707,12.073,5.262,7.535,6.377,,False,12.073,,neutral,neutral,neutral,,False,7.535,,neutral,neutral,neutral,damaging,,-0.3664,0.8986,-22.2419,-6.13525996681711,0.6736527943234092,Uncertain,0.9933,pathogenic,-4.153,available,https://doi.org/10.1101/2022.10.22.513328 +A161C,NP_000537:p.Ala161Cys,,,,,saturation_mutlist,,,,,,,,-0.19068,-0.5561150741577149,,0.9431471255362961,,0.37623356276814807,,Neutral,Neutral,,Neutral,0.24548389960471523,,0.2732768108882035,0.97688,,0.9334758938995261,,0.955177946949763,,Neutral,,Neutral,,0.13215660639162152,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.2503,0.9816,-22.239,-4.49556005485196,0.7267499076720001,Pathogenic,0.9503,pathogenic,-4.182,available,https://doi.org/10.1101/2022.10.22.513328 +A161D,NP_000537:p.Ala161Asp,"hg19,17:g.7578448G>T, hg19,17:g.7675130G>T, hg38,17:g.7675130G>T",,,0.908,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",422295,Conflicting classifications of pathogenicity,1,,,,,2.12785,1.861752257347107,2.405556666666667,2.019568336778308,2.2667033333333335,2.073709168389154,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.29737218215583383,1.4383775369105598,0.3298728533603616,4.22045,3.21372,1.9793940925316909,3.717085,3.099922046265845,Destabilizing,Uncertain,Destabilizing,Destabilizing,1.0720562366779085,0.33631145123442663,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.332,0.9816,-22.239,-6.93735650167601,0.8705275416768172,Pathogenic,0.9987,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161E,NP_000537:p.Ala161Glu,,,,,saturation_mutlist,,,,,,,,1.94816,1.64998281955719,,1.8779552173889051,,1.9130576086944524,,Neutral,Uncertain,,Neutral,0.37577938273857736,,0.6609011685234354,4.67456,,1.6892739303160254,,3.1819169651580124,,Uncertain,,Destabilizing,,0.23111558339909188,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.3176,0.9816,-22.239,-6.93735650167601,0.8707342242878764,Pathogenic,0.9983,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +A161F,NP_000537:p.Ala161Phe,"hg38,17:g.7675130_7675131delinsAA",,,,"COSMIC,saturation_mutlist",,,,,,,,4.0291,0.10588201761245727,4.734806666666667,0.10775593926097989,4.381953333333334,2.06842796963049,Destabilizing,Uncertain,Neutral,Destabilizing,Uncertain,0.4088656274586392,4.824459563946573,1.4712909563911363,12.38022,6.425056666666667,0.7532403456013466,9.402638333333334,6.566730172800673,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.5555600012199902,0.300483426103662,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.3004,0.9816,-22.239,-6.93735650167601,0.86057056466432,Pathogenic,0.995,pathogenic,-4.393,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161G,NP_000537:p.Ala161Gly,"hg19,17:g.7578447_7578448delinsTC, hg19,17:g.7578448G>C, hg38,17:g.7675129_7675130delinsTC, hg38,17:g.7675130G>C",,,0.809,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3460338,Uncertain significance,1,,,,,1.68881,1.0820348381996154,2.5506833333333336,2.4548868771835166,2.119746666666667,2.071848438591758,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.31060728959609035,0.4110887497311932,0.2966183793935749,0.46692,2.15023,2.6881415979737846,1.308575,1.5775307989868923,Uncertain,Uncertain,Neutral,Neutral,0.24191595496508,0.4778389729936543,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.2438,0.9816,-22.239,-6.51573930634988,0.7869818846508665,Pathogenic,0.7679,pathogenic,-4.063,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161H,NP_000537:p.Ala161His,,,,,saturation_mutlist,,,,,,,,3.61023,1.2761953806877135,,0.9472342411870861,,2.278732120593543,,Uncertain,Uncertain,,Uncertain,0.37848251853901566,,1.0881054939595896,12.54607,,1.2273260736937186,,6.88669803684686,,Uncertain,,Destabilizing,,0.31452556891850336,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.3045,0.9816,-22.239,-6.93735650167601,0.8667690769504365,Pathogenic,0.999,pathogenic,-4.393,available,https://doi.org/10.1101/2022.10.22.513328 +A161I,NP_000537:p.Ala161Ile,,,,,saturation_mutlist,,,,,,,,-0.9444,-0.6424124431610108,,-0.20913381539325457,,-0.5767669076966273,,Neutral,Neutral,,Neutral,0.3866945370063603,,0.9121112301675314,2.36064,,-0.3397749391478084,,1.010432530426096,,Uncertain,,Neutral,,0.26857919683357856,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.2899,0.9816,-22.239,-5.38283723695913,0.7672439487367823,Pathogenic,0.984,pathogenic,-4.076,available,https://doi.org/10.1101/2022.10.22.513328 +A161K,NP_000537:p.Ala161Lys,,,,,saturation_mutlist,,,,,,,,3.04128,1.757379150390625,,2.7708727045311505,,2.9060763522655755,,Uncertain,Uncertain,,Uncertain,0.35108568543116764,,1.6724495797453771,7.03288,,2.976746585962889,,5.004813292981444,,Uncertain,,Destabilizing,,0.40419576121383605,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.3223,0.9816,-22.239,-6.68621541521553,0.8199796158353415,Pathogenic,0.9996,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328 +A161L,NP_000537:p.Ala161Leu,,,,,saturation_mutlist,,,,,,,,-0.8858,-0.24215599298477172,,-0.14571439240158932,,-0.5157571962007946,,Neutral,Neutral,,Neutral,0.46496380589512315,,1.0083312139401162,2.63981,,-0.569050493903185,,1.0353797530484077,,Uncertain,,Neutral,,0.36878915448318916,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.2946,0.9816,-22.239,-5.03374028199389,0.2302807973793351,Benign,0.8551,pathogenic,-3.778,available,https://doi.org/10.1101/2022.10.22.513328 +A161M,NP_000537:p.Ala161Met,,,,,saturation_mutlist,,,,,,,,-0.59979,-0.0008384203910827637,,0.35411588962901436,,-0.12283705518549284,,Neutral,Neutral,,Neutral,0.39872266125153133,,0.8901934868851218,2.80554,,0.10439573323677398,,1.4549678666183872,,Uncertain,,Neutral,,0.21467351078359015,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.2534,0.9816,-22.239,-4.89819363771835,0.5579765632502982,Uncertain,0.9748,pathogenic,-3.895,available,https://doi.org/10.1101/2022.10.22.513328 +A161N,NP_000537:p.Ala161Asn,,,,,"COSMIC,saturation_mutlist",,,,,,,,1.43499,1.5359785127639771,1.5300433333333334,1.1238723795821393,1.4825166666666667,1.2794311897910697,Neutral,Neutral,Uncertain,Neutral,Neutral,0.32162807073282296,0.4924492824195762,0.40515507916580606,3.5257,3.0045366666666666,0.8757105587010111,3.2651183333333336,2.2007052793505055,Destabilizing,Uncertain,Destabilizing,Uncertain,0.9949688027381672,0.29954155063317056,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.3024,0.9816,-22.239,-6.93735650167601,0.869962268212941,Pathogenic,0.996,pathogenic,-4.35,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161P,NP_000537:p.Ala161Pro,"hg19,17:g.7578449C>G, hg38,17:g.7675131C>G",,,0.641,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3258033,,,Uncertain significance,1,,,-0.55014,1.370311963558197,1.2150800000000002,3.8565320690056972,0.3324700000000001,1.6531960345028487,Neutral,Uncertain,Uncertain,Neutral,Neutral,0.4845867304141727,1.3164858370930799,0.7365525157070814,1.20883,2.81372,3.664919012278459,2.011275,2.4368745061392296,Uncertain,Uncertain,Uncertain,Uncertain,1.8161250953059374,0.9003785351850143,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.2622,0.9816,-0.7864,-1.97218037891763,0.0062827088077968,Benign,0.6616,pathogenic,-3.236,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161Q,NP_000537:p.Ala161Gln,,,,,saturation_mutlist,,,,,,,,1.73279,1.47272540807724,,1.1933459474464698,,1.463067973723235,,Neutral,Uncertain,,Neutral,0.35557945659763385,,0.6295448750131137,4.51855,,0.9654994062911558,,2.742024703145578,,Uncertain,,Uncertain,,0.195040255234269,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.2998,0.9816,-22.239,-6.93735650167601,0.8693768162184736,Pathogenic,0.9959,pathogenic,-4.363,available,https://doi.org/10.1101/2022.10.22.513328 +A161R,NP_000537:p.Ala161Arg,,,,,saturation_mutlist,,,,,,,,5.82826,1.8009799909591675,,1.7531357747405873,,3.790697887370294,,Uncertain,Uncertain,,Destabilizing,0.35762430947230217,,1.6160025115518935,10.88417,,1.8741124137567784,,6.379141206878389,,Uncertain,,Destabilizing,,0.26717407124280707,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.333,0.9816,-22.239,-6.68621541521553,0.8678597531210588,Pathogenic,0.9971,pathogenic,-4.434,available,https://doi.org/10.1101/2022.10.22.513328 +A161S,NP_000537:p.Ala161Ser,"hg19,17:g.7578449C>A, hg19,17:g.7675131C>A, hg38,17:g.7675131C>A",,,0.752,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.81807,0.7948656475543976,1.4522700000000002,1.5170555405658679,1.13517,1.1675627702829339,Neutral,Neutral,Neutral,Neutral,Neutral,0.22203018447537473,0.22226656668664022,0.22634014665187854,1.29959,1.52687,1.4758385418877478,1.41323,1.387714270943874,Neutral,Neutral,Neutral,Neutral,0.5160069449791027,0.3513128132681692,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,uncertain,,-0.215,0.9816,-22.239,-2.6744212924387,0.6274457528900252,Uncertain,0.782,pathogenic,-3.941,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161T,NP_000537:p.Ala161Thr,"hg19,17:g.7578449C>T, hg19,17:g.7675131C>T, hg38,17:g.7675129_7675131delinsAGT, hg38,17:g.7675131C>T",,,0.790,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",161518,Pathogenic/Likely pathogenic,2,,,,,0.27702,0.3908150064945221,1.40578,0.7805216013218986,0.8414,0.5287708006609493,Neutral,Neutral,Neutral,Neutral,Neutral,0.28636169347515955,0.264048212390591,0.2829300354511663,1.67013,1.9995433333333335,0.7290243000431533,1.8348366666666667,1.1995771500215766,Neutral,Neutral,Neutral,Neutral,0.7730409946151339,0.09451951962540975,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.2209,0.9816,-22.239,-4.49556005485196,0.8467989928906021,Pathogenic,0.9563,pathogenic,-3.885,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161V,NP_000537:p.Ala161Val,"hg19,17:g.7578448G>A, hg19,17:g.7675130G>A, hg38,17:g.7675130G>A",,,0.803,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2019530,Uncertain significance,2,,,,,-1.26952,-0.8586918878555297,0.6908166666666666,-0.29685575406024417,-0.2893516666666667,-0.783187877030122,Neutral,Neutral,Neutral,Neutral,Neutral,0.36748711863353206,0.6432135289483751,0.6291622614233602,0.7516,1.3290266666666666,-0.31986686210594467,1.0403133333333332,0.2158665689470277,Neutral,Neutral,Neutral,Neutral,0.36954241049648895,0.12284398642109945,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.218,0.9816,-22.239,-4.45493542331487,0.4081706732339358,Uncertain,0.8937,pathogenic,-3.604,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161W,NP_000537:p.Ala161Trp,,,,,saturation_mutlist,,,,,,,,9.37482,0.4831125628948212,,0.8888060714804177,,5.131813035740208,,Uncertain,Neutral,,Destabilizing,0.40826397552869065,,1.9778328959004776,19.92512,,1.77863746481687,,10.851878732408435,,Uncertain,,Destabilizing,,0.4793507116951764,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.3113,0.9816,-22.239,-6.93735650167601,0.8703795534490344,Pathogenic,0.9997,pathogenic,-4.642,available,https://doi.org/10.1101/2022.10.22.513328 +A161Y,NP_000537:p.Ala161Tyr,,,,,saturation_mutlist,,,,,,,,7.25648,0.5275073575973511,,0.7008876081168364,,3.9786838040584183,,Uncertain,Neutral,,Destabilizing,0.41574958806383383,,1.613375386955682,16.78077,,1.621272309988706,,9.201021154994354,,Uncertain,,Destabilizing,,0.3973077157848081,7.495,2.584,1.27,1.295,,False,7.495,,neutral,neutral,neutral,,False,1.27,,neutral,neutral,neutral,neutral,,-0.3195,0.9816,-22.239,-6.93735650167601,0.8704707130705853,Pathogenic,0.9988,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328 +I162A,NP_000537:p.Ile162Ala,,,,,saturation_mutlist,,,,,,,,2.69592,1.5185804176330566,,1.6911905043318798,,2.19355525216594,,Uncertain,Uncertain,,Uncertain,0.43014583070941154,,0.31775397563888436,1.44441,,2.058806443491713,,1.7516082217458564,,Uncertain,,Neutral,,0.2953159221740165,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.3426,0.9099,-22.239,-5.52849042925434,0.1171671181663313,Benign,0.95,pathogenic,-3.632,available,https://doi.org/10.1101/2022.10.22.513328 +I162C,NP_000537:p.Ile162Cys,,,,,saturation_mutlist,,,,,,,,2.16284,0.8428062057495117,,1.7060223018223655,,1.9344311509111827,,Uncertain,Neutral,,Neutral,0.29694350273681636,,0.3226905897734271,1.05952,,2.1640604566161508,,1.6117902283080754,,Uncertain,,Neutral,,0.221111487384166,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.3226,0.9099,-22.239,-5.75718582247629,0.7386498378221988,Pathogenic,0.956,pathogenic,-3.965,available,https://doi.org/10.1101/2022.10.22.513328 +I162D,NP_000537:p.Ile162Asp,,,,,saturation_mutlist,,,,,,,,2.68168,2.6456957626342774,,2.7254024792157945,,2.7035412396078975,,Uncertain,Destabilizing,,Uncertain,0.513488165664849,,0.4802323736284692,3.38248,,2.896910934651656,,3.1396954673258284,,Uncertain,,Destabilizing,,0.3468804281303845,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.4666,0.9099,-22.239,-6.17096696338336,0.7526404753076472,Pathogenic,0.9994,pathogenic,-4.432,available,https://doi.org/10.1101/2022.10.22.513328 +I162E,NP_000537:p.Ile162Glu,,,,,saturation_mutlist,,,,,,,,2.94663,2.0746144533157347,,2.3694506254789673,,2.658040312739484,,Uncertain,Destabilizing,,Uncertain,0.40845393189516294,,0.46141483941559114,3.85593,,2.4464053176403002,,3.15116765882015,,Uncertain,,Destabilizing,,0.41860900508811716,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.4475,0.9099,-22.239,-6.17096696338336,0.7414635729319449,Pathogenic,0.9975,pathogenic,-4.22,available,https://doi.org/10.1101/2022.10.22.513328 +I162F,NP_000537:p.Ile162Phe,"hg19,17:g.7578446T>A, hg19,17:g.7675128T>A, hg38,17:g.7675128T>A",,,0.676,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",948225,Conflicting classifications of pathogenicity,1,,,,,5.23527,1.1262222194671632,1.8763033333333334,0.6616986365673491,3.5557866666666667,2.9484843182836746,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.24187653950127055,0.6372135165093583,0.31053847923938255,3.74441,0.8907033333333333,0.8774294363881753,2.3175566666666665,2.3109197181940875,Uncertain,Uncertain,Uncertain,Uncertain,0.48933909887611565,0.2288619749410899,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.3035,0.9099,-22.239,-5.55546634057379,0.5610062374276473,Uncertain,0.7741,pathogenic,-3.864,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I162G,NP_000537:p.Ile162Gly,,,,,saturation_mutlist,,,,,,,,3.48362,2.531654887199402,,3.165768448443792,,3.324694224221896,,Destabilizing,Destabilizing,,Destabilizing,0.5265565339385183,,0.48363172204276883,1.91974,,3.4261139246010495,,2.672926962300525,,Uncertain,,Uncertain,,0.3762345606374055,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.4332,0.9099,-22.239,-6.17096696338336,0.3185698272600161,Benign,0.9946,pathogenic,-4.054,available,https://doi.org/10.1101/2022.10.22.513328 +I162H,NP_000537:p.Ile162His,,,,,saturation_mutlist,,,,,,,,5.86107,1.9501556301116942,,1.3542713708567506,,3.607670685428375,,Uncertain,Uncertain,,Destabilizing,0.33030203768637806,,0.39390621556321737,4.46557,,1.624527067738665,,3.0450485338693323,,Uncertain,,Destabilizing,,0.24599374265230858,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.4332,0.9099,-22.239,-5.8430531674617,0.7600855709718031,Pathogenic,0.9946,pathogenic,-4.196,available,https://doi.org/10.1101/2022.10.22.513328 +I162K,NP_000537:p.Ile162Lys,,,,,saturation_mutlist,,,,,,,,3.02653,2.2727113151550293,,2.4306062906375314,,2.728568145318766,,Uncertain,Destabilizing,,Uncertain,0.39184237030786884,,0.8587244492927483,2.86579,,2.101178810246983,,2.4834844051234914,,Uncertain,,Uncertain,,0.5418019044482374,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,uncertain,,-0.44,0.9099,-22.239,-5.39971652932221,0.3743779722378239,Uncertain,0.9923,pathogenic,-4.074,available,https://doi.org/10.1101/2022.10.22.513328 +I162L,NP_000537:p.Ile162Leu,,,,,saturation_mutlist,,,,,,,,0.56212,0.7877714300155639,,0.13005688740652607,,0.346088443703263,,Neutral,Neutral,,Neutral,0.2680794696178997,,0.25999940602392324,0.52686,,0.533280749943423,,0.5300703749717115,,Neutral,,Neutral,,0.12135649251955341,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,uncertain,,-0.2278,0.9099,-22.239,-2.64933215783147,0.0456621295224262,Benign,0.4472,ambiguous,-3.391,available,https://doi.org/10.1101/2022.10.22.513328 +I162M,NP_000537:p.Ile162Met,"hg19,17:g.7578444G>C, hg38,17:g.7675126G>C",,,0.629,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.0438,0.9247933983802795,1.0836733333333333,0.6720180823469031,0.5199366666666666,0.31410904117345156,Neutral,Neutral,Neutral,Neutral,Neutral,0.34645820261321775,0.5581041894564929,0.21476346875803193,0.16284,2.2486366666666666,1.085743391567935,1.2057383333333334,0.6242916957839676,Uncertain,Neutral,Neutral,Neutral,0.8008262600311976,0.16918729535016291,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,uncertain,,-0.2334,0.9099,-22.239,-2.83824126760049,0.0113200841889445,Benign,0.4763,ambiguous,-3.401,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I162N,NP_000537:p.Ile162Asn,"hg19,17:g.7578445A>T, hg19,17:g.7675127A>T, hg38,17:g.7675127A>T",,,0.800,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1408611,Conflicting classifications of pathogenicity,1,,,,,2.8608,2.5398181772232054,2.80374,1.6922403914388784,2.83227,2.276520195719439,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,0.4646807887871657,0.3533487949132793,0.2968406282748054,1.89976,2.5130366666666664,1.9037204281519085,2.206398333333333,1.901740214075954,Uncertain,Neutral,Uncertain,Neutral,0.18120573672547519,0.3228750791068052,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.3797,0.9099,-22.239,-6.17096696338336,0.7569032171412376,Pathogenic,0.9882,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I162P,NP_000537:p.Ile162Pro,,,,,saturation_mutlist,,,,,,,,4.34075,3.0404512739181517,,5.45600731053576,,4.89837865526788,,Destabilizing,Destabilizing,,Destabilizing,0.39468297317377043,,1.0400618767999317,2.50868,,5.382380984308544,,3.945530492154272,,Uncertain,,Destabilizing,,0.1944969862389114,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.4866,0.9099,-22.239,-6.17096696338336,0.7652740247519739,Pathogenic,0.9976,pathogenic,-4.302,available,https://doi.org/10.1101/2022.10.22.513328 +I162Q,NP_000537:p.Ile162Gln,,,,,saturation_mutlist,,,,,,,,2.79026,1.9668628525733949,,1.6628421678349088,,2.2265510839174545,,Uncertain,Uncertain,,Uncertain,0.43493869843912,,0.390219719859265,2.44076,,1.8718892867632695,,2.1563246433816348,,Uncertain,,Uncertain,,0.3226853374511963,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.4073,0.9099,-22.239,-6.17096696338336,0.2661369884207849,Benign,0.9926,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328 +I162R,NP_000537:p.Ile162Arg,,,,,saturation_mutlist,,,,,,,,4.5663,2.126627836227417,,1.6070950772579813,,3.0866975386289908,,Uncertain,Destabilizing,,Destabilizing,0.3968099657277595,,0.7651460186971965,4.48946,,1.4869898552840588,,2.9882249276420296,,Uncertain,,Uncertain,,0.4885866090782862,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.4668,0.9099,-22.239,-5.69058193528002,0.6978860813106065,Pathogenic,0.9843,pathogenic,-4.05,available,https://doi.org/10.1101/2022.10.22.513328 +I162S,NP_000537:p.Ile162Ser,"hg19,17:g.7578445A>C, hg38,17:g.7675127A>C",,,0.865,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127813,Conflicting classifications of pathogenicity,1,,,,,2.99182,1.8247846508026122,2.9973933333333336,2.361176029143739,2.994606666666667,2.6764980145718695,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.4850230155298215,0.2512584785081335,0.422479160548861,1.74195,3.63696,2.5326799921906726,2.689455,2.1373149960953364,Uncertain,Uncertain,Uncertain,Uncertain,0.6345199840824558,0.29133280990979427,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.3153,0.9099,-8.9511,-5.75718582247629,0.0534169987640842,Benign,0.9693,pathogenic,-3.764,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I162T,NP_000537:p.Ile162Thr,"hg19,17:g.7578445A>G, hg38,17:g.7675127A>G",,,0.798,"ClinVar,saturation_mutlist",1992967,Uncertain significance,1,,,,,1.90076,1.2416539430618285,1.40635,1.2920648103025938,1.6535549999999999,1.596412405151297,Neutral,Neutral,Uncertain,Neutral,Neutral,0.37716365857944434,0.18548046312213054,0.3918751172942464,1.5039,1.9125833333333333,1.8532783411360463,1.7082416666666667,1.6785891705680231,Neutral,Neutral,Neutral,Neutral,0.36349307965290834,0.28280895721056687,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.2999,0.9099,-22.239,-5.75718582247629,0.5196488408575574,Uncertain,0.9144,pathogenic,-3.726,available,https://doi.org/10.1101/2022.10.22.513328 +I162V,NP_000537:p.Ile162Val,"hg19,17:g.7578446T>C, hg38,17:g.7675128T>C",,,0.498,"COSMIC,ClinVar,saturation_mutlist",1743548,Uncertain significance,1,,,,,0.69335,0.2865275192260742,-0.011450000000000016,0.16980577776831707,0.34095,0.43157788888415854,Neutral,Neutral,Neutral,Neutral,Neutral,0.15320279618686078,0.281395693759991,0.2545736087680326,0.11207,0.20408333333333337,0.8043973878594523,0.1580766666666667,0.4582336939297261,Neutral,Neutral,Neutral,Neutral,0.3135631096853639,0.34742424359507657,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.077,0.9099,-0.5042,-0.462147024394601,2.876198913679699e-09,Benign,0.0931,benign,-2.83,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I162W,NP_000537:p.Ile162Trp,,,,,saturation_mutlist,,,,,,,,7.76836,1.231652228832245,,1.0637352510798543,,4.416047625539927,,Uncertain,Uncertain,,Destabilizing,0.27657994565755567,,0.8390026777625269,8.65759,,0.8839926164455703,,4.770791308222785,,Uncertain,,Destabilizing,,0.2820035725271633,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.3246,0.9099,-8.9511,-5.8430531674617,0.8045207572051666,Pathogenic,0.9929,pathogenic,-4.374,available,https://doi.org/10.1101/2022.10.22.513328 +I162Y,NP_000537:p.Ile162Tyr,,,,,saturation_mutlist,,,,,,,,7.29718,1.2457841229438782,,1.2111132355039522,,4.254146617751976,,Uncertain,Uncertain,,Destabilizing,0.29192790910226424,,0.573273630360553,6.53433,,1.2026355595695946,,3.868482779784797,,Uncertain,,Destabilizing,,0.2253916836328785,0.487,1.093,4.525,4.415,,False,0.487,,neutral,neutral,neutral,,False,4.525,,neutral,neutral,neutral,neutral,,-0.4013,0.9099,-22.239,-5.8430531674617,0.7454748767414325,Pathogenic,0.9763,pathogenic,-4.182,available,https://doi.org/10.1101/2022.10.22.513328 +Y163A,NP_000537:p.Tyr163Ala,,,,,saturation_mutlist,,,,,,,,2.6241,2.2295392417907713,,3.6896804820015343,,3.156890241000767,,Uncertain,Destabilizing,,Destabilizing,0.5996976397204946,,0.1706232826286165,-2.73289,,2.689379785828067,,-0.021755107085966507,,Uncertain,,Neutral,,0.6213454163822502,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.442,0.1096,-22.2419,-7.83850975984194,0.8692588042206815,Pathogenic,0.9992,pathogenic,-4.482,available,https://doi.org/10.1101/2022.10.22.513328 +Y163C,NP_000537:p.Tyr163Cys,"hg19,17:g.7578442T>C, hg19,17:g.7675124T>C, hg38,17:g.7675124T>C",,,0.872,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127814,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,2.57223,1.3342476797103882,3.0871866666666663,3.97445906141392,2.829708333333333,3.27334453070696,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,0.6162170485739525,0.38922845188340954,0.1850470579162662,-2.77974,2.9155333333333338,2.9917199787254276,0.06789666666666694,0.10598998936271387,Uncertain,Uncertain,Neutral,Neutral,1.6633412809228965,0.44645429534521874,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.3448,0.1096,-8.9541,-7.83850975984194,0.4586809845101737,Uncertain,0.9824,pathogenic,-3.814,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y163D,NP_000537:p.Tyr163Asp,"hg19,17:g.7578443A>C, hg19,17:g.7675125A>C, hg38,17:g.7675125A>C",,,0.906,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",187052,Conflicting classifications of pathogenicity,1,,,,,3.12515,2.7265891456604003,3.675056666666667,4.484456496611471,3.4001033333333335,3.8048032483057357,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.5036518464795161,0.702652977428324,0.19946987149151252,-0.74788,4.888776666666666,3.909124103034335,2.070448333333333,1.5806220515171676,Uncertain,Uncertain,Uncertain,Neutral,1.2001154715091191,0.7488194476684977,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.4562,0.1096,-22.2419,-7.83850975984194,0.8692680938652717,Pathogenic,0.9992,pathogenic,-4.596,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y163E,NP_000537:p.Tyr163Glu,,,,,saturation_mutlist,,,,,,,,3.11787,2.4145927572250367,,4.005219993437346,,3.561544996718673,,Destabilizing,Destabilizing,,Destabilizing,0.5571880955212952,,0.2795394200492213,-0.5391,,3.3842900628194763,,1.4225950314097382,,Uncertain,,Neutral,,0.8096534606276591,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.4849,0.1096,-22.2419,-7.83850975984194,0.8706025804523456,Pathogenic,0.9998,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328 +Y163F,NP_000537:p.Tyr163Phe,"hg19,17:g.7578442T>A",,,0.723,"cBioPortal,saturation_mutlist",,,,,,,,-0.47063,0.36117676019668576,-0.41825666666666667,0.07127961667522034,-0.4444433333333333,-0.19967519166238984,Neutral,Neutral,Neutral,Neutral,Neutral,0.32123643610809116,0.1383861075236801,0.1654137990426687,-0.88428,0.41507999999999995,1.0095035730633466,-0.2346,0.06261178653167332,Neutral,Neutral,Neutral,Neutral,0.33601637936267337,0.6212530653191605,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.2015,0.1096,-6.9542,-2.74211411025487,0.0025652413863638,Benign,0.2372,benign,-3.306,available,https://doi.org/10.1101/2022.10.22.513328 +Y163G,NP_000537:p.Tyr163Gly,,,,,saturation_mutlist,,,,,,,,3.52846,2.2711584115028383,,5.371246027015581,,4.4498530135077905,,Destabilizing,Destabilizing,,Destabilizing,0.6091972282164317,,0.31437761544720544,-2.4804,,4.3495310575917,,0.9345655287958501,,Uncertain,,Neutral,,0.7558787766489939,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.5125,0.1096,-22.2419,-7.83850975984194,0.8696756315287439,Pathogenic,0.9958,pathogenic,-4.59,available,https://doi.org/10.1101/2022.10.22.513328 +Y163H,NP_000537:p.Tyr163His,"hg19,17:g.7578443A>G, hg19,17:g.7675125A>G, hg38,17:g.7675125A>G",,,0.904,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376680,Pathogenic,3,,,,,2.03383,1.2622168374061584,2.1916100000000003,2.1283370512359014,2.1127200000000004,2.0810835256179505,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.422134437058381,0.2218119965195751,0.12642754345151372,-1.01024,2.9333333333333336,2.266814703382814,0.9615466666666668,0.6282873516914069,Uncertain,Uncertain,Neutral,Neutral,0.7628761655005933,0.7127894432989269,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.3497,0.1096,-22.2419,-4.63018780181566,0.8549106552265939,Pathogenic,0.9929,pathogenic,-3.94,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y163I,NP_000537:p.Tyr163Ile,,,,,saturation_mutlist,,,,,,,,1.27959,1.4212494659423829,,2.0461053129902553,,1.6628476564951278,,Uncertain,Uncertain,,Neutral,0.7634737517053617,,0.25702000551396614,-3.16396,,1.2437318960297865,,-0.9601140519851067,,Uncertain,,Neutral,,0.357287634197198,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.454,0.1096,-22.2419,-7.83850975984194,0.8663560522415912,Pathogenic,0.9983,pathogenic,-4.482,available,https://doi.org/10.1101/2022.10.22.513328 +Y163K,NP_000537:p.Tyr163Lys,,,,,saturation_mutlist,,,,,,,,3.65861,1.7556754446029663,,4.408529035749564,,4.033569517874782,,Destabilizing,Uncertain,,Destabilizing,0.9251782865684732,,0.412391049971123,-1.78318,,3.309547476304546,,0.7631837381522729,,Uncertain,,Neutral,,0.9974398985368185,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.5102,0.1096,-22.2419,-7.83850975984194,0.8680679157940165,Pathogenic,0.9996,pathogenic,-4.616,available,https://doi.org/10.1101/2022.10.22.513328 +Y163L,NP_000537:p.Tyr163Leu,,,,,saturation_mutlist,,,,,,,,0.46629,1.0724946403503417,,1.4998389635031508,,0.9830644817515755,,Neutral,Uncertain,,Neutral,0.8792286332452974,,0.09907125828959672,-3.80141,,0.9530147060149096,,-1.4241976469925453,,Uncertain,,Neutral,,0.4863021559448724,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.3633,0.1096,-8.9541,-7.83850975984194,0.8571578588117306,Pathogenic,0.9894,pathogenic,-4.276,available,https://doi.org/10.1101/2022.10.22.513328 +Y163M,NP_000537:p.Tyr163Met,,,,,saturation_mutlist,,,,,,,,0.08293,1.3963337802886964,,2.024958860570078,,1.0539444302850391,,Uncertain,Uncertain,,Neutral,0.7751998220278167,,0.058584788430691336,-3.59222,,1.560909002424512,,-1.0156554987877442,,Uncertain,,Neutral,,0.41588035977340326,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.3832,0.1096,-22.2419,-7.83850975984194,0.8547996128182295,Pathogenic,0.9977,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328 +Y163N,NP_000537:p.Tyr163Asn,"hg19,17:g.7578443A>T, hg19,17:g.7578443_7578444delinsTA, hg19,17:g.7675125A>T, hg38,17:g.7675125A>T",,,0.907,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376679,Conflicting classifications of pathogenicity,1,,,,,2.7361,2.0529820799827574,3.346826666666667,3.5353318332769224,3.0414633333333336,3.1357159166384614,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.576739471591397,0.414854612391163,0.11832647160113549,-1.83691,3.493766666666667,2.9504433205125373,0.8284283333333335,0.5567666602562686,Uncertain,Uncertain,Neutral,Neutral,1.2556551946117835,0.5684221113185419,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.4352,0.1096,-22.2419,-7.83850975984194,0.8569736234526466,Pathogenic,0.9958,pathogenic,-4.412,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y163P,NP_000537:p.Tyr163Pro,,,,,saturation_mutlist,,,,,,,,0.49104,1.8861542773246764,,6.075712811268663,,3.2833764056343315,,Uncertain,Uncertain,,Destabilizing,0.6304356517647495,,0.33855632202196934,-1.16929,,6.735021348465292,,2.782865674232646,,Uncertain,,Uncertain,,0.7134085782640824,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.5662,0.1096,-22.2419,-7.83850975984194,0.8696300503786667,Pathogenic,0.9985,pathogenic,-4.563,available,https://doi.org/10.1101/2022.10.22.513328 +Y163Q,NP_000537:p.Tyr163Gln,,,,,saturation_mutlist,,,,,,,,3.12653,2.0638514494895936,,3.3815187543454677,,3.2540243771727337,,Destabilizing,Destabilizing,,Destabilizing,0.7269886076170939,,0.24275851419294767,-1.75546,,2.6794978521762247,,0.46201892608811235,,Uncertain,,Neutral,,0.6596390045044334,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.4597,0.1096,-22.2419,-7.83850975984194,0.8699101773433094,Pathogenic,0.9995,pathogenic,-4.413,available,https://doi.org/10.1101/2022.10.22.513328 +Y163R,NP_000537:p.Tyr163Arg,,,,,saturation_mutlist,,,,,,,,4.90422,1.5872032642364502,,3.4353174548364453,,4.169768727418223,,Destabilizing,Uncertain,,Destabilizing,0.8729464729133388,,0.2740117027300309,-0.19863,,2.4339038674898497,,1.1176369337449248,,Uncertain,,Neutral,,0.85205091690105,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.5055,0.1096,-22.2419,-7.83850975984194,0.8705766682395808,Pathogenic,0.9974,pathogenic,-4.454,available,https://doi.org/10.1101/2022.10.22.513328 +Y163S,NP_000537:p.Tyr163Ser,"hg19,17:g.7578442T>G, hg38,17:g.7675124T>G",,,0.901,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2757988,Uncertain significance,1,,,,,3.40079,2.276040725708008,3.990816666666667,4.447860156957379,3.6958033333333336,3.92432507847869,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.643070091365311,0.5535562408243228,0.23479760155320598,-2.18693,3.8672299999999997,3.5299162754967557,0.84015,0.6714931377483779,Uncertain,Uncertain,Neutral,Neutral,1.5624124076141568,0.7116864104979401,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.4467,0.1096,-22.2419,-7.83850975984194,0.8701990254434995,Pathogenic,0.9949,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y163T,NP_000537:p.Tyr163Thr,,,,,saturation_mutlist,,,,,,,,3.48322,2.0488611888885497,,3.5996023857684,,3.5414111928842003,,Destabilizing,Destabilizing,,Destabilizing,0.6819572457561348,,0.18327333819774683,-2.71216,,2.721130211056914,,0.004485105528457156,,Uncertain,,Neutral,,0.5612283486579379,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.4653,0.1096,-22.2419,-7.83850975984194,0.8684686729564621,Pathogenic,0.999,pathogenic,-4.472,available,https://doi.org/10.1101/2022.10.22.513328 +Y163V,NP_000537:p.Tyr163Val,,,,,saturation_mutlist,,,,,,,,2.04809,1.7194598698616028,,2.5224434223509906,,2.2852667111754954,,Uncertain,Uncertain,,Uncertain,0.6583366380574434,,0.16044776817340323,-3.36733,,1.5228558428265557,,-0.9222370785867221,,Uncertain,,Neutral,,0.3575113629685074,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,uncertain,,-0.4436,0.1096,-22.2419,-7.83850975984194,0.8642682821084049,Pathogenic,0.9965,pathogenic,-4.432,available,https://doi.org/10.1101/2022.10.22.513328 +Y163W,NP_000537:p.Tyr163Trp,,,,,saturation_mutlist,,,,,,,,2.36096,0.5208133912086487,,0.6416218965021909,,1.5012909482510954,,Uncertain,Neutral,,Neutral,0.28941861809472663,,0.22415733635482007,2.04167,,1.1815860408105958,,1.611628020405298,,Uncertain,,Neutral,,1.0458404873043554,1.21,1.097,5.11,3.435,,False,1.21,,uncertain,,,,False,5.11,,uncertain,,,neutral,,-0.3595,0.1096,-22.2419,-4.70351320819519,0.870302303289236,Pathogenic,0.8813,pathogenic,-4.332,available,https://doi.org/10.1101/2022.10.22.513328 +K164A,NP_000537:p.Lys164Ala,,,,,saturation_mutlist,,,,,,,,0.57633,-0.01409241437911986,,0.2541026273515125,,0.4152163136757563,,Neutral,Neutral,,Neutral,0.3027381562992158,,0.0610276883005643,0.49472,,0.187039930483594,,0.340879965241797,,Neutral,,Neutral,,0.15904060139910128,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3163,0.0678,-22.2419,-5.10596589958081,0.1391736952409238,Benign,0.9414,pathogenic,-4.004,available,https://doi.org/10.1101/2022.10.22.513328 +K164C,NP_000537:p.Lys164Cys,,,,,saturation_mutlist,,,,,,,,0.66008,-0.23235219478607178,,0.7977107050136779,,0.7288953525068389,,Neutral,Neutral,,Neutral,0.3320821667418491,,0.04257838326067447,0.7487,,0.7752084386457048,,0.7619542193228523,,Neutral,,Neutral,,0.2083812550098588,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3865,0.0678,-22.2419,-5.44896686250668,0.5013011992055324,Uncertain,0.9482,pathogenic,-4.21,available,https://doi.org/10.1101/2022.10.22.513328 +K164D,NP_000537:p.Lys164Asp,,,,,saturation_mutlist,,,,,,,,1.18122,0.8153292143344879,,0.7408102837020726,,0.9610151418510362,,Neutral,Neutral,,Neutral,0.40655329136088586,,0.06188767123121865,1.29978,,0.596901137210802,,0.948340568605401,,Neutral,,Neutral,,0.2369021616335016,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.4253,0.0678,-22.2419,-6.9942592743991,0.837169630482437,Pathogenic,0.9935,pathogenic,-4.5,available,https://doi.org/10.1101/2022.10.22.513328 +K164E,NP_000537:p.Lys164Glu,"hg19,17:g.7578440T>C, hg19,17:g.7675122T>C, hg38,17:g.7675122T>C",,,0.875,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",246416,Pathogenic,3,,,,,0.90789,0.538736447095871,1.1697266666666668,0.5434660212717767,1.0388083333333333,0.7256780106358883,Neutral,Neutral,Neutral,Neutral,Neutral,0.32189622771959553,0.08279254247146227,0.08466053912696979,1.23157,1.37381,0.4581284941951635,1.3026900000000001,0.8448492470975818,Neutral,Neutral,Neutral,Neutral,0.8099939517469664,0.15015260808821285,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3412,0.0678,-22.2419,-6.13403327025882,0.3646032755188367,Uncertain,0.9696,pathogenic,-4.122,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K164F,NP_000537:p.Lys164Phe,,,,,saturation_mutlist,,,,,,,,-0.055,0.2304955780506134,,-0.1793237035575397,,-0.11716185177876985,,Neutral,Neutral,,Neutral,0.2461688540219554,,0.317564029288597,-0.02453,,-0.25548232591051007,,-0.14000616295525503,,Neutral,,Neutral,,0.0575772653122571,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,neutral,,-0.3874,0.0678,-22.2419,-7.56538754350299,0.8669078559905607,Pathogenic,0.9952,pathogenic,-4.636,available,https://doi.org/10.1101/2022.10.22.513328 +K164G,NP_000537:p.Lys164Gly,,,,,saturation_mutlist,,,,,,,,1.20954,0.5410065019130706,,1.1042931943770442,,1.156916597188522,,Neutral,Neutral,,Neutral,0.332814635312393,,0.0472930589862185,1.05398,,1.0298786227099719,,1.041929311354986,,Neutral,,Neutral,,0.30498253123985763,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3755,0.0678,-22.2419,-7.82858939090521,0.7863547222567662,Pathogenic,0.9522,pathogenic,-4.28,available,https://doi.org/10.1101/2022.10.22.513328 +K164H,NP_000537:p.Lys164His,,,,,saturation_mutlist,,,,,,,,0.96125,0.20772089958190917,,-0.019274654960278432,,0.4709876725198608,,Neutral,Neutral,,Neutral,0.24715674941046242,,0.11045070218842958,0.62343,,-0.09077443291939484,,0.2663277835403026,,Neutral,,Neutral,,0.05702857252111489,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3264,0.0678,-22.2419,-7.56538754350299,0.8675117059848358,Pathogenic,0.8487,pathogenic,-4.33,available,https://doi.org/10.1101/2022.10.22.513328 +K164I,NP_000537:p.Lys164Ile,,,,,saturation_mutlist,,,,,,,,0.15113,-0.09144482374191285,,-0.0476061504797796,,0.0517619247601102,,Neutral,Neutral,,Neutral,0.38596570886648546,,0.29980817954034455,1.9286,,-0.1179801538468322,,0.905309923076584,,Neutral,,Neutral,,0.05109113524444075,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3546,0.0678,-22.2419,-5.96296308666808,0.5449997164933468,Uncertain,0.9769,pathogenic,-4.347,available,https://doi.org/10.1101/2022.10.22.513328 +K164L,NP_000537:p.Lys164Leu,,,,,saturation_mutlist,,,,,,,,-0.27425,-0.08444711208343506,,-0.43416180364717594,,-0.35420590182358797,,Neutral,Neutral,,Neutral,0.3225094341397282,,0.1481106180007056,-0.24249,,-0.6712471347733309,,-0.4568685673866654,,Neutral,,Neutral,,0.01931763213975929,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3533,0.0678,-22.2419,-5.07410976626896,0.503376901087779,Uncertain,0.9306,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328 +K164M,NP_000537:p.Lys164Met,"hg19,17:g.7578439T>A, hg38,17:g.7675121T>A",,,0.925,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.2209,-0.06978188514709473,0.3266466666666667,-0.043809664842528295,0.05287333333333334,-0.13235483242126417,Neutral,Neutral,Neutral,Neutral,Neutral,0.28092988334395647,0.11602201409885778,0.2398347110232596,-0.03385,0.39093,-0.19798717775685903,0.17854,-0.11591858887842951,Neutral,Neutral,Neutral,Neutral,0.5292706153440475,0.10892853289803445,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3264,0.0678,-22.2419,-4.95330904216767,0.2508344765534155,Benign,0.901,pathogenic,-4.007,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K164N,NP_000537:p.Lys164Asn,"hg19,17:g.7578438C>A, hg19,17:g.7578438C>G, hg19,17:g.7675120C>A, hg38,17:g.7675120C>A, hg38,17:g.7675120C>G",,,0.794,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2848594, 428899","Uncertain significance, Uncertain significance","1, 1",,,,,0.93566,0.41100292921066284,0.48344999999999994,0.3033149049022878,0.7095549999999999,0.6194874524511439,Neutral,Neutral,Neutral,Neutral,Neutral,0.25506042189867595,0.19130589971735493,0.042873466768656866,0.51968,-0.15419666666666668,0.14518218894970514,0.1827416666666667,0.3324310944748526,Neutral,Neutral,Neutral,Neutral,0.5432246609726853,0.21688760153959527,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3345,0.0678,-22.2419,-6.9942592743991,0.7698240855821997,Pathogenic,0.983,pathogenic,-4.238,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K164P,NP_000537:p.Lys164Pro,,,,,saturation_mutlist,,,,,,,,0.63384,0.8815787053108215,,1.8890610578590545,,1.2614505289295272,,Neutral,Neutral,,Neutral,0.6693063793607507,,0.3781939071680797,1.99791,,5.468819920590352,,3.733364960295176,,Uncertain,,Destabilizing,,0.534774595553744,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.4906,0.0678,-22.2419,-7.82858939090521,0.7722193709959284,Pathogenic,0.9931,pathogenic,-4.366,available,https://doi.org/10.1101/2022.10.22.513328 +K164Q,NP_000537:p.Lys164Gln,"hg19,17:g.7578440T>G, hg38,17:g.7675122T>G",,,0.899,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2687712,Uncertain significance,0,,,,,0.54847,0.10625141620635986,0.6530633333333333,0.40870314943636893,0.6007666666666667,0.47858657471818444,Neutral,Neutral,Neutral,Neutral,Neutral,0.19198568061161042,0.22470671260309266,0.15157212771786954,0.57637,0.21088666666666667,0.32731192516956203,0.39362833333333336,0.451840962584781,Neutral,Neutral,Neutral,Neutral,0.06897463801201778,0.10576084991996276,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3155,0.0678,-22.2419,-4.46414505079612,0.6164651683915742,Uncertain,0.5962,pathogenic,-3.98,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K164R,NP_000537:p.Lys164Arg,"hg19,17:g.7578439T>C, hg38,17:g.7675121T>C",,,0.906,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.48279,0.06558998227119446,-0.008956666666666668,-0.09830661295178493,0.23691666666666666,0.19224169352410753,Neutral,Neutral,Neutral,Neutral,Neutral,0.062318538182732135,0.17461360949886529,0.18131731434947135,0.1685,0.5191600000000001,-0.18037098838372398,0.34383,-0.005935494191861984,Neutral,Neutral,Neutral,Neutral,0.17242240708987525,0.08627413782379695,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.1719,0.0678,-6.9542,-1.79641753144727,0.0029539731212726,Benign,0.1385,benign,-3.382,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K164S,NP_000537:p.Lys164Ser,,,,,saturation_mutlist,,,,,,,,1.09736,0.1353403401374817,,0.4827786184151477,,0.7900693092075738,,Neutral,Neutral,,Neutral,0.28349786882262484,,0.049340743318141776,1.22288,,0.6402408007947044,,0.9315604003973521,,Neutral,,Neutral,,0.21518859857175504,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3264,0.0678,-22.2419,-5.05904966575694,0.0382170755871565,Benign,0.9419,pathogenic,-3.776,available,https://doi.org/10.1101/2022.10.22.513328 +K164T,NP_000537:p.Lys164Thr,"hg19,17:g.7578439T>G, hg38,17:g.7675121T>G",,,0.927,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.09697,0.11944700956344605,0.11746000000000001,0.3743480111593492,0.6072150000000001,0.7356590055796746,Neutral,Neutral,Neutral,Neutral,Neutral,0.3652686872556355,0.4210797698773951,0.14661271075120527,2.06495,1.94898,0.48385193940679344,2.006965,1.2744009697033967,Uncertain,Uncertain,Uncertain,Neutral,0.21218560758606286,0.17587226290627164,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3383,0.0678,-22.2419,-4.89004485921964,0.3095712567729934,Benign,0.8969,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K164V,NP_000537:p.Lys164Val,,,,,saturation_mutlist,,,,,,,,0.60145,-0.09323461413383484,,-0.04973341764057009,,0.275858291179715,,Neutral,Neutral,,Neutral,0.4454784641621649,,0.2740177945253094,1.5822,,-0.06147824556327581,,0.7603608772183621,,Neutral,,Neutral,,0.14504392987640283,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,uncertain,,-0.3385,0.0678,-22.2419,-6.17425991523464,0.5084372117824716,Uncertain,0.952,pathogenic,-4.123,available,https://doi.org/10.1101/2022.10.22.513328 +K164W,NP_000537:p.Lys164Trp,,,,,saturation_mutlist,,,,,,,,0.80936,0.24574466586112975,,-0.47881750049879207,,0.16527124975060395,,Neutral,Neutral,,Neutral,0.2632837721235775,,0.29670317509353245,0.57159,,-0.5662101242523888,,0.0026899378738056146,,Neutral,,Neutral,,0.17413481630167935,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,neutral,,-0.3964,0.0678,-22.2419,-7.56538754350299,0.8274083640378417,Pathogenic,0.9896,pathogenic,-4.558,available,https://doi.org/10.1101/2022.10.22.513328 +K164Y,NP_000537:p.Lys164Tyr,,,,,saturation_mutlist,,,,,,,,0.15852,0.21765438675880433,,-0.0495850330965806,,0.054467483451709695,,Neutral,Neutral,,Neutral,0.2904154690799786,,0.2622323593319545,0.22644,,-0.1072206385948254,,0.0596096807025873,,Neutral,,Neutral,,0.07229736242482998,43.48,6.818,51.515,8.188,,False,43.48,,neutral,neutral,neutral,,False,51.515,,neutral,neutral,neutral,neutral,,-0.3723,0.0678,-22.2419,-7.56538754350299,0.8680802653289659,Pathogenic,0.9784,pathogenic,-4.503,available,https://doi.org/10.1101/2022.10.22.513328 +Q165A,NP_000537:p.Gln165Ala,,,,,saturation_mutlist,,,,,,,,0.24634,0.003926486968994137,,0.120451450376447,,0.1833957251882235,,Neutral,Neutral,,Neutral,0.06696750750971785,,0.1875992808799721,-0.13135,,0.23320053563273202,,0.05092526781636601,,Neutral,,Neutral,,0.22111581718000697,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,damaging,,-0.2507,0.5346,-22.239,-4.6221152236935,5.868975472295857e-06,Benign,0.3009,benign,-3.106,available,https://doi.org/10.1101/2022.10.22.513328 +Q165C,NP_000537:p.Gln165Cys,,,,,saturation_mutlist,,,,,,,,0.33677,-0.35918038606643676,,0.6911842790142811,,0.5139771395071406,,Neutral,Neutral,,Neutral,0.0945035017866824,,0.14848071528484794,-0.0604,,0.6173623680395361,,0.27848118401976807,,Neutral,,Neutral,,0.1706782910490852,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,damaging,,-0.2969,0.5346,-22.239,-4.94605015438188,2.028080132610777e-07,Benign,0.8166,pathogenic,-3.118,available,https://doi.org/10.1101/2022.10.22.513328 +Q165D,NP_000537:p.Gln165Asp,,,,,saturation_mutlist,,,,,,,,0.04012,-0.47620916843414307,,-0.12678329173978173,,-0.04333164586989086,,Neutral,Neutral,,Neutral,0.16827876765758898,,0.14735164186246247,-0.32604,,0.16734088849653972,,-0.07934955575173014,,Neutral,,Neutral,,0.1732404390912431,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,damaging,,-0.3372,0.5346,-22.239,-3.82900690144397,1.187126582962172e-06,Benign,0.6544,pathogenic,-3.097,available,https://doi.org/10.1101/2022.10.22.513328 +Q165E,NP_000537:p.Gln165Glu,"hg19,17:g.7578437G>C, hg38,17:g.7675119G>C",,,0.572,"COSMIC,ClinVar,saturation_mutlist",3634431,Uncertain significance,1,,,,,-0.09642,-0.3701895523071289,-0.13752666666666666,-0.21521512075340174,-0.11697333333333333,-0.15581756037670086,Neutral,Neutral,Neutral,Neutral,Neutral,0.16296213922207076,0.15616694002110548,0.19215728147581193,-0.41284,0.24625666666666665,0.12178917966720122,-0.08329166666666667,-0.1455254101663994,Neutral,Neutral,Neutral,Neutral,0.38323863839069716,0.15759225677880767,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,damaging,,-0.188,0.5346,-8.9511,-3.79832456836452,9.176279346988106e-08,Benign,0.238,benign,-2.951,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q165F,NP_000537:p.Gln165Phe,,,,,saturation_mutlist,,,,,,,,-0.58475,-0.016417266130447396,,-0.6737798757696319,,-0.629264937884816,,Neutral,Neutral,,Neutral,0.13401786957350745,,0.03260157518020708,-0.21483,,-0.14102105096203743,,-0.1779255254810187,,Neutral,,Neutral,,0.26680510860996426,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,neutral,,-0.3049,0.5346,-22.239,-5.91989421718138,0.0001193992474123,Benign,0.8864,pathogenic,-3.488,available,https://doi.org/10.1101/2022.10.22.513328 +Q165G,NP_000537:p.Gln165Gly,,,,,saturation_mutlist,,,,,,,,0.4455,0.10106678009033203,,0.8490790994564392,,0.6472895497282196,,Neutral,Neutral,,Neutral,0.35998574679034645,,0.2232893172760039,-1.09704,,0.534431028806298,,-0.281304485596851,,Neutral,,Neutral,,0.1820583358227944,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,damaging,,-0.3213,0.5346,-22.239,-4.12485339031954,1.245270409518038e-07,Benign,0.4131,ambiguous,-3.096,available,https://doi.org/10.1101/2022.10.22.513328 +Q165H,NP_000537:p.Gln165His,"hg19,17:g.7578435C>A, hg38,17:g.7675117C>A, hg38,17:g.7675117C>G",,,0.600,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.36951,-0.1035852551460266,-0.13367333333333334,-0.5436700251840038,0.11791833333333333,-0.08708001259200188,Neutral,Neutral,Neutral,Neutral,Neutral,0.09859113411783225,0.5007519115845246,0.12203285030708867,0.1424,0.38515000000000005,-0.19161272082919378,0.26377500000000004,-0.024606360414596892,Neutral,Neutral,Neutral,Neutral,0.3136836056708522,0.1560617265019207,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,neutral,,-0.2518,0.5346,-22.239,-5.91989421718138,1.6049705327078507e-05,Benign,0.3948,ambiguous,-3.229,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q165I,NP_000537:p.Gln165Ile,,,,,saturation_mutlist,,,,,,,,-0.11919,0.15521332144737243,,-0.5475764198957006,,-0.3333832099478503,,Neutral,Neutral,,Neutral,0.1681972224932074,,0.031758112936106496,1.43164,,0.19217773714091943,,0.8119088685704597,,Neutral,,Neutral,,0.5173998877421183,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,neutral,,-0.2863,0.5346,-22.239,-4.61721972138562,2.4726695642988905e-05,Benign,0.7338,pathogenic,-3.296,available,https://doi.org/10.1101/2022.10.22.513328 +Q165K,NP_000537:p.Gln165Lys,"hg19,17:g.7578437G>T, hg38,17:g.7675119G>T",,,0.481,"cBioPortal,ClinVar,saturation_mutlist",482232,Conflicting classifications of pathogenicity,1,,,,,-0.17222,0.22967971324920655,0.21723333333333336,-0.06982750046599225,0.022506666666666675,-0.12102375023299614,Neutral,Neutral,Neutral,Neutral,Neutral,0.18972668513296315,0.36179879328464076,0.24006539122176127,-0.00099,0.96043,0.036870466778693066,0.47972,0.017940233389346534,Neutral,Neutral,Neutral,Neutral,0.6322266182311529,0.11753917463126608,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,neutral,,-0.171,0.5346,-0.1311,0.597145055795084,1.595742701002255e-23,Benign,0.1186,benign,-2.698,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q165L,NP_000537:p.Gln165Leu,"hg19,17:g.7578436T>A, hg38,17:g.7675118T>A",,,0.574,"COSMIC,ClinVar,saturation_mutlist",2505496,Pathogenic,0,,,,,-0.60308,0.10454549312591553,-0.55839,-0.786187824585455,-0.580735,-0.6946339122927274,Neutral,Neutral,Neutral,Neutral,Neutral,0.10342873789753526,0.18723266755563786,0.06109826938090025,-0.3397,-0.12199666666666666,-0.40660635699722186,-0.23084833333333332,-0.37315317849861096,Neutral,Neutral,Neutral,Neutral,0.4498614257993479,0.30404342916330296,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,neutral,,-0.2696,0.5346,-22.239,-3.1479277378225,4.5110084836118185e-08,Benign,0.2476,benign,-3.032,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q165M,NP_000537:p.Gln165Met,,,,,saturation_mutlist,,,,,,,,-0.78885,0.10045890450477599,,-0.37040773872174354,,-0.5796288693608718,,Neutral,Neutral,,Neutral,0.04861270239780255,,0.03362271612708774,-0.29428,,-0.13635434881552164,,-0.21531717440776083,,Neutral,,Neutral,,0.20788699223159435,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,neutral,,-0.2406,0.5346,-22.239,-4.45370527071802,5.094235296928069e-06,Benign,0.4253,ambiguous,-3.177,available,https://doi.org/10.1101/2022.10.22.513328 +Q165N,NP_000537:p.Gln165Asn,,,,,saturation_mutlist,,,,,,,,0.34734,-0.14541379928588866,,-0.1555676340639026,,0.0958861829680487,,Neutral,Neutral,,Neutral,0.19907739400088936,,0.11024287137699551,-0.04616,,-0.15973179328068057,,-0.10294589664034029,,Neutral,,Neutral,,0.07443202428842322,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,damaging,,-0.1985,0.5346,-8.9511,-0.728888358913719,1.226965580192127e-12,Benign,0.3741,ambiguous,-2.838,available,https://doi.org/10.1101/2022.10.22.513328 +Q165P,NP_000537:p.Gln165Pro,"hg38,17:g.7675118T>G",,,0.653,"COSMIC,saturation_mutlist",,,,,,,,1.15115,0.5187793540954589,2.283106666666667,2.0732245722589124,1.7171283333333334,1.6121872861294562,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.22610136061870653,0.4371812823328809,0.23350103594280475,7.22426,5.391496666666666,5.013256353773334,6.307878333333333,6.118758176886667,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.6718997468042057,0.506927654928801,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,damaging,,-0.4243,0.5346,-22.239,-6.30577079745317,0.0004309376365346,Benign,0.5766,pathogenic,-3.41,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q165R,NP_000537:p.Gln165Arg,"hg38,17:g.7675118T>C",,,0.475,"COSMIC,saturation_mutlist",,,,,,,,-0.00073,0.25446829199790955,0.26973,-0.3096960334188488,0.1345,-0.15521301670942442,Neutral,Neutral,Neutral,Neutral,Neutral,0.19091726935572415,0.22148078803062507,0.1666400453986952,0.13491,1.2334466666666666,-0.19820777065598705,0.6841783333333333,-0.03164888532799352,Neutral,Neutral,Neutral,Neutral,0.5575497328689364,0.23618485076992732,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,neutral,,-0.1993,0.5346,-5.9513,-0.744174817524804,2.855191870853627e-13,Benign,0.2235,benign,-2.686,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q165S,NP_000537:p.Gln165Ser,,,,,saturation_mutlist,,,,,,,,0.57168,-0.1262919783592224,,0.18314920390280917,,0.3774146019514046,,Neutral,Neutral,,Neutral,0.15730496335969002,,0.26184052232029564,0.01088,,0.38876742063188613,,0.19982371031594306,,Neutral,,Neutral,,0.15902834702710666,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,damaging,,-0.1962,0.5346,-7.9512,-3.25589551056651,7.583367232924971e-10,Benign,0.3367,benign,-2.905,available,https://doi.org/10.1101/2022.10.22.513328 +Q165T,NP_000537:p.Gln165Thr,,,,,saturation_mutlist,,,,,,,,0.75315,-0.11850408792495726,,0.04625459661593797,,0.399702298307969,,Neutral,Neutral,,Neutral,0.1815150299710561,,0.15161074261546076,0.65452,,0.45379140797832834,,0.5541557039891641,,Neutral,,Neutral,,0.3567452487937359,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,damaging,,-0.279,0.5346,-22.239,-4.49684013715844,2.6779692222751912e-06,Benign,0.3102,benign,-3.016,available,https://doi.org/10.1101/2022.10.22.513328 +Q165V,NP_000537:p.Gln165Val,,,,,saturation_mutlist,,,,,,,,0.48079,0.20647188305854797,,-0.37751597591804414,,0.051637012040977925,,Neutral,Neutral,,Neutral,0.19760381732225735,,0.05783930828715046,1.50401,,0.27850433567449856,,0.8912571678372493,,Neutral,,Neutral,,0.48077125635492757,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,uncertain,,-0.2864,0.5346,-22.239,-4.73702447938161,1.879993012737302e-05,Benign,0.5143,ambiguous,-3.244,available,https://doi.org/10.1101/2022.10.22.513328 +Q165W,NP_000537:p.Gln165Trp,,,,,saturation_mutlist,,,,,,,,-0.75278,-0.021033458709716776,,-0.9980147155758486,,-0.8753973577879244,,Neutral,Neutral,,Neutral,0.12537912967673606,,0.11085455533032466,0.07034,,-0.3496092448308114,,-0.1396346224154057,,Neutral,,Neutral,,0.24557536589138998,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,neutral,,-0.3043,0.5346,-22.239,-5.91989421718138,0.002444726602777,Benign,0.8866,pathogenic,-3.536,available,https://doi.org/10.1101/2022.10.22.513328 +Q165Y,NP_000537:p.Gln165Tyr,,,,,saturation_mutlist,,,,,,,,-0.48083,-0.05917418479919432,,-0.5745824754179306,,-0.5277062377089653,,Neutral,Neutral,,Neutral,0.1104453483275676,,0.10004447701999564,-0.08017,,-0.019208499019003133,,-0.04968924950950157,,Neutral,,Neutral,,0.23191578396564946,66.717,12.887,53.4,9.686,,False,66.717,,neutral,neutral,neutral,,False,53.4,,neutral,neutral,neutral,neutral,,-0.3072,0.5346,-22.239,-5.91989421718138,3.5163131553633387e-06,Benign,0.7491,pathogenic,-3.322,available,https://doi.org/10.1101/2022.10.22.513328 +S166A,NP_000537:p.Ser166Ala,"hg19,17:g.7578434A>C, hg38,17:g.7675116A>C",,,0.487,"COSMIC,ClinVar,saturation_mutlist",2687713,Uncertain significance,0,,,,,-0.25308,-0.016598505973815913,-0.15918333333333334,-0.22926325996717897,-0.20613166666666669,-0.24117162998358949,Neutral,Neutral,Neutral,Neutral,Neutral,0.0487176721643112,0.06639277889114817,0.19845839155130168,-0.05186,-0.08129333333333333,0.22453868138844535,-0.06657666666666667,0.08633934069422267,Neutral,Neutral,Neutral,Neutral,0.0073479263892762435,0.28663525080284036,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.0352,1.4753,-0.7705,-1.6681715036531,0.000147551899433,Benign,0.0945,benign,-3.0,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S166C,NP_000537:p.Ser166Cys,,,,,saturation_mutlist,,,,,,,,0.15084,-0.11594286203384398,,0.6456576891550483,,0.39824884457752413,,Neutral,Neutral,,Neutral,0.05292614916283365,,0.20583622959268782,0.16287,,0.8759300206640624,,0.5194000103320312,,Neutral,,Neutral,,0.20179320204129858,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.1274,1.4753,-8.9453,-1.66978399331955,0.2685763719008316,Benign,0.3307,benign,-3.808,available,https://doi.org/10.1101/2022.10.22.513328 +S166D,NP_000537:p.Ser166Asp,,,,,saturation_mutlist,,,,,,,,-0.19921,0.3358824300765991,,-0.4682926829978283,,-0.33375134149891417,,Neutral,Neutral,,Neutral,0.14366364825072184,,0.3225689164197979,-0.09786,,-0.18129728836394846,,-0.13957864418197424,,Neutral,,Neutral,,0.1872540664707361,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.2434,1.4753,-22.2332,-4.83317350903605,0.0795670691728424,Benign,0.8878,pathogenic,-3.689,available,https://doi.org/10.1101/2022.10.22.513328 +S166E,NP_000537:p.Ser166Glu,,,,,saturation_mutlist,,,,,,,,-0.54772,0.0056138038635253976,,-0.5072215463650034,,-0.5274707731825017,,Neutral,Neutral,,Neutral,0.08642082956782987,,0.21658886459487375,-0.08193,,-0.07459337581993224,,-0.07826168790996613,,Neutral,,Neutral,,0.1556676620523804,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.2166,1.4753,-22.2332,-4.96003878416074,0.1591370218912332,Benign,0.8608,pathogenic,-3.746,available,https://doi.org/10.1101/2022.10.22.513328 +S166F,NP_000537:p.Ser166Phe,,,,,saturation_mutlist,,,,,,,,-0.5674,0.14224538087844849,,-0.4759106724323882,,-0.5216553362161941,,Neutral,Neutral,,Neutral,0.14828699960752312,,0.20784536232316114,-0.05505,,-0.0813390188021031,,-0.06819450940105155,,Neutral,,Neutral,,0.3295897468608179,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.2228,1.4753,-22.2332,-5.72708266180734,0.4638692962826835,Uncertain,0.5969,pathogenic,-3.948,available,https://doi.org/10.1101/2022.10.22.513328 +S166G,NP_000537:p.Ser166Gly,"hg38,17:g.7675115_7675116delinsCC",,,,"COSMIC,saturation_mutlist",,,,,,,,0.08454,0.31848140954971316,0.5715433333333334,0.29364579978631,0.3280416666666667,0.189092899893155,Neutral,Neutral,Neutral,Neutral,Neutral,0.0720822106779194,0.0816843552272336,0.266994114886896,-0.18669,0.6928566666666667,0.5484110819265337,0.2530833333333333,0.1808605409632668,Neutral,Neutral,Neutral,Neutral,0.0121053716267706,0.12509111207216406,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,neutral,,-0.1539,1.4753,-22.2332,-6.3247105867852,0.7514509966966355,Pathogenic,0.3208,benign,-3.823,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S166H,NP_000537:p.Ser166His,,,,,saturation_mutlist,,,,,,,,0.1057,-0.029931347370147705,,-0.626924038307679,,-0.26061201915383947,,Neutral,Neutral,,Neutral,0.1308586861095342,,0.31118343345478217,0.29134,,-0.23750552721013188,,0.026917236394934055,,Neutral,,Neutral,,0.19751142333307625,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.224,1.4753,-22.2332,-5.07831126174798,0.2524368444732401,Benign,0.7686,pathogenic,-3.711,available,https://doi.org/10.1101/2022.10.22.513328 +S166I,NP_000537:p.Ser166Ile,"hg38,17:g.7675114_7675116delinsGAT",,,,"COSMIC,saturation_mutlist",,,,,,,,-0.20887,0.08177982091903684,-0.11394666666666665,-0.2936799427435856,-0.16140833333333332,-0.2512749713717928,Neutral,Neutral,Neutral,Neutral,Neutral,0.10227688290161614,0.1431121458468459,0.047496938568961755,0.53463,0.2466,0.1386290429680768,0.39061500000000005,0.3366295214840384,Neutral,Neutral,Neutral,Neutral,0.0836635272983395,0.26500132714868224,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.1581,1.4753,-8.9453,-3.49392141879354,0.312513367970137,Benign,0.5185,ambiguous,-3.863,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S166K,NP_000537:p.Ser166Lys,,,,,saturation_mutlist,,,,,,,,-0.5446,-0.10594927072525023,,-0.34550113688182443,,-0.4450505684409122,,Neutral,Neutral,,Neutral,0.09115998588486349,,0.24756264516560697,-0.00947,,0.012497698671108374,,0.0015138493355541871,,Neutral,,Neutral,,0.19325480277483595,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.2333,1.4753,-22.2332,-6.3247105867852,0.815608427253362,Pathogenic,0.9574,pathogenic,-3.982,available,https://doi.org/10.1101/2022.10.22.513328 +S166L,NP_000537:p.Ser166Leu,"hg19,17:g.7578433G>A, hg38,17:g.7675115G>A",,,0.613,"COSMIC,ClinVar,saturation_mutlist",528239,Uncertain significance,2,,,,,-0.60038,0.12478969097137449,-0.45430666666666664,-0.7438188492160361,-0.5273433333333333,-0.6720994246080181,Neutral,Neutral,Neutral,Neutral,Neutral,0.09343030959081165,0.16747623519638707,0.2407672512254234,0.02246,0.05805,-0.272827983675981,0.040255,-0.1251839918379905,Neutral,Neutral,Neutral,Neutral,0.0872581014385866,0.343398244646369,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.1361,1.4753,-5.3605,-1.83955355180868,5.412090413575097e-05,Benign,0.1355,benign,-3.348,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S166M,NP_000537:p.Ser166Met,,,,,saturation_mutlist,,,,,,,,-0.72584,0.11019523859024045,,-0.3901579893389986,,-0.5579989946694993,,Neutral,Neutral,,Neutral,0.08179203615467745,,0.2467160646178832,0.00803,,0.05944518182528927,,0.03373759091264463,,Neutral,,Neutral,,0.26165157041110426,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.1932,1.4753,-22.2332,-5.12945473682947,0.4403665723890536,Uncertain,0.2784,benign,-3.774,available,https://doi.org/10.1101/2022.10.22.513328 +S166N,NP_000537:p.Ser166Asn,,,,,saturation_mutlist,,,,,,,,0.05447,0.14123479366302488,,-0.30646752765520685,,-0.12599876382760342,,Neutral,Neutral,,Neutral,0.07497886156641008,,0.3101501471718842,0.09586,,0.024320740515958228,,0.060090370257979114,,Neutral,,Neutral,,0.19553969638969423,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.167,1.4753,-22.2332,-5.21572547745391,0.3342154321828632,Uncertain,0.5809,pathogenic,-3.66,available,https://doi.org/10.1101/2022.10.22.513328 +S166P,NP_000537:p.Ser166Pro,"hg38,17:g.7675116A>G",,,0.707,"COSMIC,saturation_mutlist",,,,,,,,-1.4972,-0.2968620729446411,-0.9937633333333332,0.39800479792451454,-1.2454816666666666,-0.5495976010377428,Neutral,Neutral,Neutral,Neutral,Neutral,0.08592934910405363,0.2721184867336694,0.5797711318164301,-0.389,-0.6742633333333333,0.49344606652249007,-0.5316316666666667,0.05222303326124503,Neutral,Neutral,Neutral,Neutral,0.19915057826233448,0.22985149137904,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.216,1.4753,-6.1381,-2.90524947974682,0.0001486018049043,Benign,0.3253,benign,-3.253,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S166Q,NP_000537:p.Ser166Gln,,,,,saturation_mutlist,,,,,,,,-0.27188,-0.05205900907516479,,-0.1967998868355989,,-0.23433994341779946,,Neutral,Neutral,,Neutral,0.056447534423662835,,0.2638802770927541,0.06319,,0.23210435759032455,,0.14764717879516226,,Neutral,,Neutral,,0.15734838574231266,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.1866,1.4753,-22.2332,-5.21572547745391,0.5059740437916836,Uncertain,0.7497,pathogenic,-3.823,available,https://doi.org/10.1101/2022.10.22.513328 +S166R,NP_000537:p.Ser166Arg,,,,,saturation_mutlist,,,,,,,,-0.26471,-0.030475556850433332,,-0.4460395069442733,,-0.35537475347213665,,Neutral,Neutral,,Neutral,0.12235215562004927,,0.2000184108943739,0.04432,,-0.0832399294230024,,-0.0194599647115012,,Neutral,,Neutral,,0.20689632168836455,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.2386,1.4753,-22.2332,-6.3247105867852,0.6705894350091829,Uncertain,0.9586,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328 +S166T,NP_000537:p.Ser166Thr,"hg19,17:g.7578434A>T, hg38,17:g.7675116A>T",,,0.512,"COSMIC,ClinVar,saturation_mutlist",3809673,Likely benign,1,,,,,0.13989,0.131437212228775,0.20589666666666664,-0.1889466932266417,0.17289333333333332,-0.02452834661332086,Neutral,Neutral,Neutral,Neutral,Neutral,0.050122272441702746,0.13119694720364322,0.22681560814913673,0.33098,0.028913333333333336,0.11304641998786817,0.17994666666666667,0.2220132099939341,Neutral,Neutral,Neutral,Neutral,0.09845838963180786,0.15768541598620597,70.666,10.032,91.64,14.359,,False,70.666,,neutral,,,,False,91.64,,neutral,,,uncertain,,-0.0425,1.4753,-4.0386,-1.79366907215294,5.393523103078352e-05,Benign,0.157,benign,-3.18,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S166V,NP_000537:p.Ser166Val,,,,,saturation_mutlist,,,,,,,,0.14295,0.14578556537628173,,-0.13165776549776645,,0.005646117251116772,,Neutral,Neutral,,Neutral,0.08507020999987086,,0.059372765657244794,0.56633,,0.22538302567059132,,0.39585651283529566,,Neutral,,Neutral,,0.17010666070785374,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.2002,1.4753,-22.2332,-5.12945473682947,0.3066744558141589,Benign,0.3909,ambiguous,-3.791,available,https://doi.org/10.1101/2022.10.22.513328 +S166W,NP_000537:p.Ser166Trp,,,,,saturation_mutlist,,,,,,,,-0.7514,0.09870155572891236,,-0.9350125989254795,,-0.8432062994627397,,Neutral,Neutral,,Neutral,0.14110999841106392,,0.18502668811825293,0.11552,,-0.5213503576284728,,-0.2029151788142364,,Neutral,,Neutral,,0.3627442519979304,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.2325,1.4753,-22.2332,-5.72708266180734,0.7556672233700359,Pathogenic,0.6894,pathogenic,-4.211,available,https://doi.org/10.1101/2022.10.22.513328 +S166Y,NP_000537:p.Ser166Tyr,,,,,saturation_mutlist,,,,,,,,-0.46909,0.04824636220932007,,-0.414022295730444,,-0.441556147865222,,Neutral,Neutral,,Neutral,0.16765118835353687,,0.1535702297886559,0.02545,,-0.09701286239076996,,-0.03578143119538498,,Neutral,,Neutral,,0.34921247275330725,70.666,10.032,91.64,14.359,,False,70.666,,uncertain,,,,False,91.64,,uncertain,,,uncertain,,-0.2276,1.4753,-22.2332,-5.03590427425324,0.1766604311795214,Benign,0.5873,pathogenic,-3.878,available,https://doi.org/10.1101/2022.10.22.513328 +Q167A,NP_000537:p.Gln167Ala,,,,,saturation_mutlist,,,,,,,,0.1538,-0.036465070247650146,,0.0679174641538449,,0.11085873207692246,,Neutral,Neutral,,Neutral,0.07156468740932445,,0.09909538125274348,0.29223,,0.27560648058547793,,0.28391824029273893,,Neutral,,Neutral,,0.11589157430972707,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2297,0.7627,-22.2419,-5.05240105698553,0.0027501768451349,Benign,0.2839,benign,-3.22,available,https://doi.org/10.1101/2022.10.22.513328 +Q167C,NP_000537:p.Gln167Cys,,,,,saturation_mutlist,,,,,,,,0.25549,-0.07618730783462524,,0.7650582022182043,,0.5102741011091021,,Neutral,Neutral,,Neutral,0.08804161470449884,,0.11364423129135137,0.2043,,0.5458755620816739,,0.37508778104083695,,Neutral,,Neutral,,0.0864240930165369,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2759,0.7627,-22.2419,-5.5948838562905,0.2353664813145259,Benign,0.883,pathogenic,-3.712,available,https://doi.org/10.1101/2022.10.22.513328 +Q167D,NP_000537:p.Gln167Asp,,,,,saturation_mutlist,,,,,,,,0.11934,0.053788032531738264,,-0.2789539807495736,,-0.07980699037478681,,Neutral,Neutral,,Neutral,0.1403188168251389,,0.09076557148092722,-0.08931,,-0.36939217823210263,,-0.22935108911605132,,Neutral,,Neutral,,0.06511538508667788,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2341,0.7627,-6.1468,-2.00908986839085,1.5345097554704166e-08,Benign,0.6807,pathogenic,-2.86,available,https://doi.org/10.1101/2022.10.22.513328 +Q167E,NP_000537:p.Gln167Glu,"hg38,17:g.7675113G>C",,,0.467,"COSMIC,saturation_mutlist",,,,,,,,-0.25626,-0.16953891754150388,0.017913333333333333,-0.2782936630145125,-0.11917333333333333,-0.26727683150725623,Neutral,Neutral,Neutral,Neutral,Neutral,0.07170476163092616,0.00714206474969871,0.10344925626103633,-0.01027,0.15668666666666667,-0.04991796041978524,0.07320833333333333,-0.03009398020989262,Neutral,Neutral,Neutral,Neutral,0.30762146656059114,0.13268908216697478,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.1226,0.7627,-0.2468,-0.362404426258414,6.128985523826569e-13,Benign,0.0935,benign,-2.658,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q167F,NP_000537:p.Gln167Phe,,,,,saturation_mutlist,,,,,,,,0.17818,0.21550096511840816,,-0.2264970385905446,,-0.024158519295272296,,Neutral,Neutral,,Neutral,0.07159277328682478,,0.1352348829947987,-0.03214,,0.07056525393365694,,0.019212626966828468,,Neutral,,Neutral,,0.2944523342860038,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2839,0.7627,-22.2419,-6.36881646439402,0.2201780926149382,Benign,0.9381,pathogenic,-3.846,available,https://doi.org/10.1101/2022.10.22.513328 +Q167G,NP_000537:p.Gln167Gly,,,,,saturation_mutlist,,,,,,,,0.38967,0.2625331175327301,,0.548454126721898,,0.469062063360949,,Neutral,Neutral,,Neutral,0.10690296896200162,,0.08319081494117626,-1.09687,,0.07339063405121153,,-0.5117396829743942,,Neutral,,Neutral,,0.022704803839416657,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2326,0.7627,-8.9541,-4.90006830275617,0.000237491982194,Benign,0.466,ambiguous,-3.283,available,https://doi.org/10.1101/2022.10.22.513328 +Q167H,NP_000537:p.Gln167His,"hg19,17:g.7578429C>A, hg19,17:g.7578429C>G, hg38,17:g.7675111C>A, hg38,17:g.7675111C>G",,,"0.589, 0.592","cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.47627,0.007809729576110833,0.2300433333333333,-0.3881782667915097,0.3531566666666667,0.04404586660424517,Neutral,Neutral,Neutral,Neutral,Neutral,0.07993128477658351,0.1800222749797616,0.0654747800224336,0.16549,-0.43594333333333335,-0.30790760766685055,-0.13522666666666666,-0.07120880383342527,Neutral,Neutral,Neutral,Neutral,0.05432997965109953,0.18957761958981836,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2308,0.7627,-22.2419,-6.04298878400287,0.0021673175787741,Benign,0.5183,ambiguous,-3.251,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q167I,NP_000537:p.Gln167Ile,,,,,saturation_mutlist,,,,,,,,0.15322,0.2702159774303436,,-0.04251940567035686,,0.055350297164821566,,Neutral,Neutral,,Neutral,0.0927830843004345,,0.12202461934413418,1.65028,,1.1172539391720846,,1.3837669695860422,,Neutral,,Neutral,,0.5640193492983848,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2653,0.7627,-22.2419,-6.48335161373988,0.1760475847152851,Benign,0.6934,pathogenic,-3.662,available,https://doi.org/10.1101/2022.10.22.513328 +Q167K,NP_000537:p.Gln167Lys,"hg19,17:g.7578431G>T, hg38,17:g.7675113G>T",,,0.647,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2736423,Uncertain significance,2,,,,,-0.11524,0.16017325162887575,0.12074999999999998,-0.12883612982123224,0.0027549999999999936,-0.12203806491061611,Neutral,Neutral,Neutral,Neutral,Neutral,0.07152097829659981,0.17166569274804638,0.12559500116814468,-0.13037,-0.03151666666666666,-0.20131482699998426,-0.08094333333333334,-0.16584241349999213,Neutral,Neutral,Neutral,Neutral,0.2982541136160386,0.08429415132129338,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2629,0.7627,-22.2419,-6.65723665606982,0.0080379362292281,Benign,0.3089,benign,-3.526,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q167L,NP_000537:p.Gln167Leu,"hg38,17:g.7675112T>A",,,0.569,"COSMIC,saturation_mutlist",,,,,,,,-0.11997,0.270051691532135,-0.00022666666666666668,-0.3825139760673509,-0.06009833333333333,-0.2512419880336754,Neutral,Neutral,Neutral,Neutral,Neutral,0.0719404125368163,0.06192669555387419,0.07391768537356624,0.09164,-0.03310333333333334,-0.08402455525798803,0.02926833333333333,0.0038077223710059824,Neutral,Neutral,Neutral,Neutral,0.3358042894637027,0.36358471355835653,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2487,0.7627,-22.2419,-6.48335161373988,0.0981542411945038,Benign,0.3813,ambiguous,-3.654,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q167M,NP_000537:p.Gln167Met,,,,,saturation_mutlist,,,,,,,,-0.18151,0.2399522185325622,,-0.09081718091735413,,-0.13616359045867707,,Neutral,Neutral,,Neutral,0.04300727669304961,,0.07089889638366209,0.11211,,0.06308375039667083,,0.08759687519833542,,Neutral,,Neutral,,0.25070325944678973,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2196,0.7627,-22.2419,-6.48335161373988,0.0448589465979961,Benign,0.5716,pathogenic,-3.578,available,https://doi.org/10.1101/2022.10.22.513328 +Q167N,NP_000537:p.Gln167Asn,,,,,saturation_mutlist,,,,,,,,0.31026,0.1492611241340637,,-0.10742721018006901,,0.10141639490996548,,Neutral,Neutral,,Neutral,0.08066049603102544,,0.09828983175148673,-0.15407,,-0.44160758682273443,,-0.2978387934113672,,Neutral,,Neutral,,0.016677513440993757,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2454,0.7627,-22.2419,-3.43255365511228,0.0005376168063681,Benign,0.4789,ambiguous,-3.236,available,https://doi.org/10.1101/2022.10.22.513328 +Q167P,NP_000537:p.Gln167Pro,"hg19,17:g.7578430T>G, hg38,17:g.7675112T>G",3.18735258494e-05,,0.633,"ClinVar,saturation_mutlist",490173,Uncertain significance,2,,,,,-0.32452,0.20856133580207822,3.4435366666666667,1.535757631201088,1.5595083333333333,0.6056188156005441,Uncertain,Neutral,Neutral,Neutral,Neutral,0.16792861601043554,0.2169088271345564,0.35915151407682655,3.19175,6.1920633333333335,4.122729128129482,4.691906666666666,3.657239564064741,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.6588399224057052,0.683551357451261,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.4033,0.7627,-22.2419,-7.03120427913244,0.318063924172586,Benign,0.287,benign,-3.588,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q167R,NP_000537:p.Gln167Arg,"hg19,17:g.7578430T>C, hg38,17:g.7675112T>C",,,0.566,"COSMIC,ClinVar,saturation_mutlist",653104,Uncertain significance,1,,,,,0.07957,0.23176105856895446,-0.11882,-0.23158887364810712,-0.019624999999999997,-0.07600943682405356,Neutral,Neutral,Neutral,Neutral,Neutral,0.07031473297144382,0.16028037954368174,0.11220841591151669,-0.00347,0.10261000000000002,-0.24638619420361144,0.04957000000000001,-0.12492809710180572,Neutral,Neutral,Neutral,Neutral,0.04447888487810818,0.17781252377040804,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.1936,0.7627,-8.9541,-6.23323076244701,0.0006004832881894,Benign,0.3113,benign,-3.294,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q167S,NP_000537:p.Gln167Ser,,,,,saturation_mutlist,,,,,,,,0.30252,-0.030306386947631814,,-0.017462676457725704,,0.14252866177113716,,Neutral,Neutral,,Neutral,0.0835738029583807,,0.08228607977206508,0.2359,,0.07250920746643777,,0.15420460373321887,,Neutral,,Neutral,,0.10113354530990352,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.1722,0.7627,-7.3692,-3.27845643129039,0.0002277684968011,Benign,0.3445,ambiguous,-3.088,available,https://doi.org/10.1101/2022.10.22.513328 +Q167T,NP_000537:p.Gln167Thr,,,,,saturation_mutlist,,,,,,,,0.6792,0.1553011393547058,,-0.024973567686014834,,0.32711321615699257,,Neutral,Neutral,,Neutral,0.06201418396253334,,0.07693620655551185,0.44891,,0.6833973969411152,,0.5661536984705576,,Neutral,,Neutral,,0.3495715945777765,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2581,0.7627,-22.2419,-4.799030939519,0.0023535444557513,Benign,0.3604,ambiguous,-3.313,available,https://doi.org/10.1101/2022.10.22.513328 +Q167V,NP_000537:p.Gln167Val,,,,,saturation_mutlist,,,,,,,,0.4763,0.3077200520038605,,-0.018753017325944032,,0.22877349133702798,,Neutral,Neutral,,Neutral,0.11677540128812412,,0.16351985367159708,0.95887,,0.8211492224748663,,0.8900096112374332,,Neutral,,Neutral,,0.45438323435426853,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2654,0.7627,-22.2419,-5.97060422663239,0.1068066770839584,Benign,0.4895,ambiguous,-3.376,available,https://doi.org/10.1101/2022.10.22.513328 +Q167W,NP_000537:p.Gln167Trp,,,,,saturation_mutlist,,,,,,,,0.2621,0.15679278135299682,,-0.5622415321618291,,-0.15007076608091457,,Neutral,Neutral,,Neutral,0.09520241383803296,,0.10576472119321358,0.11402,,-0.09400273339604932,,0.010008633301975337,,Neutral,,Neutral,,0.2958061516255664,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2833,0.7627,-22.2419,-6.36881646439402,0.1905905899709199,Benign,0.9049,pathogenic,-3.904,available,https://doi.org/10.1101/2022.10.22.513328 +Q167Y,NP_000537:p.Gln167Tyr,,,,,saturation_mutlist,,,,,,,,0.2058,0.09764578819274901,,-0.21261716629155836,,-0.003408583145779173,,Neutral,Neutral,,Neutral,0.09283761663098723,,0.1340975075541481,-0.00778,,0.0975834459153156,,0.044901722957657805,,Neutral,,Neutral,,0.22658623779908502,95.515,10.916,100.62,6.669,,False,95.515,,neutral,neutral,neutral,,False,100.62,,neutral,neutral,neutral,uncertain,,-0.2862,0.7627,-22.2419,-6.36881646439402,0.2522644223292603,Benign,0.8878,pathogenic,-3.818,available,https://doi.org/10.1101/2022.10.22.513328 +H168A,NP_000537:p.His168Ala,,,,,saturation_mutlist,,,,,,,,0.70937,0.9444526648521423,,1.006179884263697,,0.8577749421318486,,Neutral,Neutral,,Neutral,0.15868340199144967,,0.3611487553971363,-0.17765,,1.160001263804406,,0.491175631902203,,Neutral,,Neutral,,0.2137319805779625,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.2584,0.4206,-22.2419,-5.86696975564203,0.5420297420236151,Uncertain,0.9222,pathogenic,-4.106,available,https://doi.org/10.1101/2022.10.22.513328 +H168C,NP_000537:p.His168Cys,,,,,saturation_mutlist,,,,,,,,0.74877,0.3065268230438232,,1.4861709032246182,,1.117470451612309,,Neutral,Neutral,,Neutral,0.10881580432007616,,0.35239602849515755,0.06079,,1.5453414745198435,,0.8030657372599217,,Neutral,,Neutral,,0.24104798471615216,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.3129,0.4206,-22.2419,-6.18696950119922,0.836989219904867,Pathogenic,0.5888,pathogenic,-4.149,available,https://doi.org/10.1101/2022.10.22.513328 +H168D,NP_000537:p.His168Asp,"hg38,17:g.7675110G>C",,,0.551,"COSMIC,saturation_mutlist",,,,,,,,0.16587,1.231568329334259,1.3120200000000002,1.347731087952587,0.7389450000000001,0.7568005439762935,Neutral,Neutral,Uncertain,Neutral,Neutral,0.24612323782447637,0.20231364956423478,0.691980989469767,1.0967,3.7332200000000006,1.4643087842186437,2.41496,1.280504392109322,Uncertain,Neutral,Uncertain,Neutral,1.0886705045451848,0.3228544070598719,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.2297,0.4206,-7.3692,-3.20664808123884,0.0009146526920434,Benign,0.6778,pathogenic,-3.703,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H168E,NP_000537:p.His168Glu,,,,,saturation_mutlist,,,,,,,,0.82822,0.9580588746070862,,1.2018623986262735,,1.0150411993131367,,Neutral,Neutral,,Neutral,0.18689654333922676,,0.6802404989942287,0.95305,,1.257456531243739,,1.1052532656218694,,Neutral,,Neutral,,0.44336732675063006,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.3171,0.4206,-22.2419,-5.59248666879771,0.8286014951367308,Pathogenic,0.9297,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328 +H168F,NP_000537:p.His168Phe,,,,,saturation_mutlist,,,,,,,,-0.824,0.293070969581604,,-0.3696139181070593,,-0.5968069590535297,,Neutral,Neutral,,Neutral,0.1986995632807163,,0.13740403032457627,-0.63686,,0.4910468687122691,,-0.07290656564386544,,Neutral,,Neutral,,0.08009681282986886,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.1945,0.4206,-5.4948,-0.474417244883146,0.0105351595136972,Benign,0.304,benign,-3.64,available,https://doi.org/10.1101/2022.10.22.513328 +H168G,NP_000537:p.His168Gly,,,,,saturation_mutlist,,,,,,,,1.44625,1.2642904949188232,,2.1988890949089366,,1.8225695474544683,,Uncertain,Uncertain,,Neutral,0.17053550799902054,,0.5169874741486661,-0.62671,,2.117199464924913,,0.7452447324624565,,Uncertain,,Neutral,,0.45322499601345745,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.3409,0.4206,-22.2419,-7.23727323630724,0.8215326963108431,Pathogenic,0.9164,pathogenic,-4.34,available,https://doi.org/10.1101/2022.10.22.513328 +H168I,NP_000537:p.His168Ile,,,,,saturation_mutlist,,,,,,,,1.61387,1.3443612623214722,,0.5586220387197497,,1.0862460193598749,,Neutral,Uncertain,,Neutral,0.2408798568544202,,0.5207894379606219,3.02546,,0.6548411117448582,,1.840150555872429,,Uncertain,,Neutral,,0.07595555716038123,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.3446,0.4206,-22.2419,-6.75123843329861,0.8704798263868494,Pathogenic,0.9492,pathogenic,-4.437,available,https://doi.org/10.1101/2022.10.22.513328 +H168K,NP_000537:p.His168Lys,,,,,saturation_mutlist,,,,,,,,0.62457,0.9417885589599609,,1.202751380147484,,0.9136606900737421,,Neutral,Neutral,,Neutral,0.16500363333811444,,0.5770068097522821,-0.04594,,1.1088809538089992,,0.5314704769044996,,Neutral,,Neutral,,0.22811685869854323,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.3013,0.4206,-22.2419,-6.60908236639589,0.8222713856449133,Pathogenic,0.9385,pathogenic,-4.096,available,https://doi.org/10.1101/2022.10.22.513328 +H168L,NP_000537:p.His168Leu,"hg19,17:g.7578427T>A, hg19,17:g.7675109T>A, hg38,17:g.7675109T>A",,,0.550,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1744933,Pathogenic,1,,,Tier I - Strong,1,-0.03173,0.7420078444480896,0.15329,0.18588904741242204,0.06078,0.07707952370621102,Neutral,Neutral,Neutral,Neutral,Neutral,0.17780256388901827,0.3365502807407337,0.36262779558669683,0.02502,0.41655333333333333,0.24434440915106512,0.22078666666666666,0.13468220457553257,Neutral,Neutral,Neutral,Neutral,0.6937930438938946,0.09255338273915512,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.3082,0.4206,-22.2419,-6.60832493435264,0.7549936755082538,Pathogenic,0.7531,pathogenic,-4.002,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H168M,NP_000537:p.His168Met,,,,,saturation_mutlist,,,,,,,,-0.09781,0.6652526926994323,,0.5071288834661519,,0.20465944173307596,,Neutral,Neutral,,Neutral,0.15250945605133337,,0.29685681913049844,-0.12884,,0.6240789283531036,,0.2476194641765518,,Neutral,,Neutral,,0.11022864683955769,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.2583,0.4206,-22.2419,-6.75123843329861,0.8512185381819232,Pathogenic,0.922,pathogenic,-4.342,available,https://doi.org/10.1101/2022.10.22.513328 +H168N,NP_000537:p.His168Asn,"hg19,17:g.7578428G>T, hg38,17:g.7675110G>T",,,0.566,"COSMIC,ClinVar,saturation_mutlist",2687697,Uncertain significance,0,,,,,0.04468,0.6381944131851196,1.0988666666666667,1.0520263188715897,0.5717733333333334,0.5483531594357949,Neutral,Neutral,Neutral,Neutral,Neutral,0.18362312496550548,0.054992575458470284,0.4784263570038606,-0.05177,0.8651933333333334,0.9833136251868178,0.4067116666666667,0.4657718125934089,Neutral,Neutral,Neutral,Neutral,0.5646273238360169,0.08485513862891375,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.2651,0.4206,-22.2419,-4.72985914704594,0.1486518005591041,Benign,0.4148,ambiguous,-3.688,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H168P,NP_000537:p.His168Pro,"hg19,17:g.7578426_7578427delinsCG, hg19,17:g.7578427T>G, hg19,17:g.7675109T>G, hg38,17:g.7675109T>G",,,0.526,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3328154,Likely pathogenic,1,,,Tier I - Strong,1,3.57943,1.8506410789489747,6.027886666666666,3.7110411884341503,4.803658333333333,3.645235594217075,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.32176938592805,0.2642391349180175,0.7163686656386677,4.06421,6.9914966666666665,5.306351144075784,5.527853333333333,4.685280572037891,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.5362126156251412,0.6762073964612725,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.4216,0.4206,-22.2419,-7.23727323630724,0.8676805747380067,Pathogenic,0.9646,pathogenic,-4.254,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H168Q,NP_000537:p.His168Gln,"hg19,17:g.7578426G>C, hg19,17:g.7578426G>T, hg19,17:g.7675108G>C, hg38,17:g.7675108G>C, hg38,17:g.7675108G>T",,,0.568,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1745001,Uncertain significance,1,,,,,0.68068,0.7097304606437683,0.8739266666666667,1.0713579432122968,0.7773033333333333,0.8760189716061484,Neutral,Neutral,Neutral,Neutral,Neutral,0.1310912790337344,0.6583810927992658,0.49180676264844714,0.74198,1.1992066666666668,1.0267088832709212,0.9705933333333334,0.8843444416354607,Neutral,Neutral,Neutral,Neutral,0.49523069050920315,0.33539397447898267,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.2266,0.4206,-22.2419,-5.46615266747081,0.4951019121086106,Uncertain,0.8384,pathogenic,-3.718,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H168R,NP_000537:p.His168Arg,"hg19,17:g.7578426_7578427delinsTC, hg19,17:g.7578427T>C, hg19,17:g.7675109T>C, hg38,17:g.7675109T>C",,,0.562,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428866,Conflicting classifications of pathogenicity,1,,,,,0.83746,0.908110659122467,0.8631533333333333,0.6499221358184321,0.8503066666666667,0.743691067909216,Neutral,Neutral,Neutral,Neutral,Neutral,0.1609975532359256,0.14639021309120664,0.4665939101022701,0.20308,0.2928566666666667,0.7122509194657957,0.24796833333333335,0.45766545973289785,Neutral,Neutral,Neutral,Neutral,0.13520351113126547,0.0936695171980716,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.2947,0.4206,-22.2419,-3.66624520956463,0.7544042602940518,Pathogenic,0.8669,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H168S,NP_000537:p.His168Ser,,,,,saturation_mutlist,,,,,,,,0.804,1.0189542007446288,,1.4933106313476963,,1.1486553156738482,,Neutral,Uncertain,,Neutral,0.17604980560905673,,0.6188823441025273,0.12354,,1.5414511306981342,,0.8324955653490671,,Neutral,,Neutral,,0.25944059384682827,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.2643,0.4206,-22.2419,-5.62823134186807,0.4313199013049166,Uncertain,0.8036,pathogenic,-3.88,available,https://doi.org/10.1101/2022.10.22.513328 +H168T,NP_000537:p.His168Thr,,,,,saturation_mutlist,,,,,,,,1.11757,1.2004812955856323,,1.0633796765629666,,1.0904748382814833,,Neutral,Uncertain,,Neutral,0.25669430507802676,,0.5211376379314406,2.08702,,1.2399059565026602,,1.6634629782513302,,Uncertain,,Neutral,,0.17203514447575788,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.3092,0.4206,-22.2419,-6.18696950119922,0.7245305599908903,Pathogenic,0.9415,pathogenic,-4.281,available,https://doi.org/10.1101/2022.10.22.513328 +H168V,NP_000537:p.His168Val,,,,,saturation_mutlist,,,,,,,,1.50049,1.3594471645355224,0.22165333333333334,0.5475713166636403,0.8610716666666667,1.0240306583318202,Neutral,Neutral,Uncertain,Neutral,Neutral,0.22657437538198863,0.08465629818402302,0.4743963763732044,2.31635,1.10578,0.6768878004563227,1.711065,1.4966189002281614,Uncertain,Uncertain,Neutral,Neutral,0.3492249811606648,0.07006401932701074,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.301,0.4206,-22.2419,-6.41564740878293,0.7516366221533969,Pathogenic,0.9113,pathogenic,-4.191,available,https://doi.org/10.1101/2022.10.22.513328 +H168W,NP_000537:p.His168Trp,,,,,saturation_mutlist,,,,,,,,0.32096,0.3367997145652771,,-0.5714141424948312,,-0.1252270712474156,,Neutral,Neutral,,Neutral,0.23688127294647765,,0.2543014570540844,0.73552,,0.32803495917955966,,0.5317774795897798,,Neutral,,Neutral,,0.10412813305582504,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.2963,0.4206,-22.2419,-4.0859338287686,0.7395136862693565,Pathogenic,0.5773,pathogenic,-4.218,available,https://doi.org/10.1101/2022.10.22.513328 +H168Y,NP_000537:p.His168Tyr,"hg19,17:g.7578428G>A, hg38,17:g.7675110G>A",,,0.501,"COSMIC,ClinVar,saturation_mutlist",4552487,Uncertain significance,1,,,,,-0.50403,-0.13164740085601806,-0.10975,-0.1881179998404936,-0.30689,-0.3460739999202468,Neutral,Neutral,Neutral,Neutral,Neutral,0.2201106999980499,0.12917713755408372,0.18190076569955937,-0.10751,-0.58118,0.6634479117225545,-0.344345,0.27796895586127723,Neutral,Neutral,Neutral,Neutral,0.5586380499631821,0.1173575906264681,26.753,6.155,43.425,10.846,,True,26.753,,neutral,neutral,neutral,,True,43.425,,neutral,neutral,neutral,damaging,,-0.1415,0.4206,-4.8667,-0.238274744609607,0.0033759433076676,Benign,0.1263,benign,-3.41,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M169A,NP_000537:p.Met169Ala,,,,,saturation_mutlist,,,,,,,,1.17389,0.4614786458015442,,0.9238922198667363,,1.0488911099333682,,Neutral,Neutral,,Neutral,0.2883925591272978,,0.3907482216374767,0.69686,,0.8582980447966477,,0.7775790223983239,,Neutral,,Neutral,,0.07993238677266414,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.2481,0.9321,-8.9541,-3.99597960154925,0.0027815006924094,Benign,0.7727,pathogenic,-3.365,available,https://doi.org/10.1101/2022.10.22.513328 +M169C,NP_000537:p.Met169Cys,,,,,saturation_mutlist,,,,,,,,1.39204,0.4246311116218567,,1.534677181888885,,1.4633585909444424,,Neutral,Neutral,,Neutral,0.21718430606380887,,0.30517130324318,1.08567,,1.3774073576346506,,1.2315386788173253,,Neutral,,Neutral,,0.05772811725440966,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.3214,0.9321,-22.2419,-5.6705964229845,0.7608210513954525,Pathogenic,0.8643,pathogenic,-3.91,available,https://doi.org/10.1101/2022.10.22.513328 +M169D,NP_000537:p.Met169Asp,,,,,saturation_mutlist,,,,,,,,2.54498,1.2610698652267456,,1.6646357810241164,,2.104807890512058,,Uncertain,Uncertain,,Uncertain,0.3103385964741923,,0.42896301571622314,1.37771,,0.977068617098155,,1.1773893085490774,,Neutral,,Neutral,,0.19288070176234806,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.4274,0.9321,-22.2419,-6.97309884514643,0.7870781404526453,Pathogenic,0.9912,pathogenic,-4.182,available,https://doi.org/10.1101/2022.10.22.513328 +M169E,NP_000537:p.Met169Glu,,,,,saturation_mutlist,,,,,,,,1.3989,0.865314245223999,,1.1881127284095792,,1.2935063642047897,,Neutral,Neutral,,Neutral,0.23867337328983745,,0.41716433217205473,0.76743,,0.6036375862463267,,0.6855337931231633,,Neutral,,Neutral,,0.09456846882698712,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.4176,0.9321,-22.2419,-6.97309884514643,0.5070434088837751,Uncertain,0.9216,pathogenic,-4.024,available,https://doi.org/10.1101/2022.10.22.513328 +M169F,NP_000537:p.Met169Phe,,,,,saturation_mutlist,,,,,,,,2.02261,0.7302804040908814,,0.35275971265393785,,1.1876848563269689,,Uncertain,Neutral,,Neutral,0.29744088669506125,,0.25713343722057935,0.76699,,0.02819238325400227,,0.39759119162700113,,Neutral,,Neutral,,0.1596094364503282,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,neutral,,-0.321,0.9321,-22.2419,-5.09771817264625,0.1152076591401682,Benign,0.688,pathogenic,-3.638,available,https://doi.org/10.1101/2022.10.22.513328 +M169G,NP_000537:p.Met169Gly,,,,,saturation_mutlist,,,,,,,,1.95809,0.7729109144210815,,1.9948773266270703,,1.9764836633135352,,Neutral,Neutral,,Neutral,0.3626403071515427,,0.41252395843691186,0.85626,,1.7377892435504423,,1.297024621775221,,Neutral,,Neutral,,0.2545627697413743,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.3968,0.9321,-22.2419,-7.21542309947019,0.6674679097821479,Uncertain,0.9474,pathogenic,-4.16,available,https://doi.org/10.1101/2022.10.22.513328 +M169H,NP_000537:p.Met169His,,,,,saturation_mutlist,,,,,,,,2.94318,0.6895124197006226,,0.7330952581213501,,1.838137629060675,,Uncertain,Neutral,,Neutral,0.28327703716735425,,0.3044508829793911,1.57197,,0.4007585382023282,,0.9863642691011641,,Neutral,,Neutral,,0.1547034525778606,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.3742,0.9321,-22.2419,-5.99304405598151,0.6189120159262327,Uncertain,0.9264,pathogenic,-4.077,available,https://doi.org/10.1101/2022.10.22.513328 +M169I,NP_000537:p.Met169Ile,"hg19,17:g.7578423C>A, hg19,17:g.7578423C>T, hg19,17:g.7675105C>T, hg38,17:g.7675105C>A, hg38,17:g.7675105C>T",,,0.597,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",919322,Uncertain significance,2,,,,,0.86244,0.6604710197448731,0.09262999999999999,0.5175785317061802,0.477535,0.6900092658530901,Neutral,Neutral,Neutral,Neutral,Neutral,0.2998947918365933,0.14766918500486148,0.24900913208058326,0.87084,0.17743999999999996,0.13847832844982066,0.5241399999999999,0.5046591642249103,Neutral,Neutral,Neutral,Neutral,0.16692306491315093,0.0556737039788478,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.1501,0.9321,-5.9542,-1.84578901987421,7.352173913828294e-05,Benign,0.6481,pathogenic,-3.026,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M169K,NP_000537:p.Met169Lys,,,,,saturation_mutlist,,,,,,,,0.91482,0.494938383102417,0.93628,1.124148787043388,0.92555,1.019484393521694,Neutral,Neutral,Neutral,Neutral,Neutral,0.49104704182799824,0.39554793245151304,0.44458431556455036,0.65142,0.8756233333333334,0.7400460622487927,0.7635216666666667,0.6957330311243963,Neutral,Neutral,Neutral,Neutral,0.2827382781930235,0.08783021108204132,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,neutral,,-0.3785,0.9321,-22.2419,-5.98260746006438,0.2028107539774008,Benign,0.7249,pathogenic,-3.796,available,https://doi.org/10.1101/2022.10.22.513328 +M169L,NP_000537:p.Met169Leu,"hg19,17:g.7578425T>A, hg38,17:g.7675107T>A",,,0.562,"cBioPortal,ClinVar,saturation_mutlist",2886753,Uncertain significance,1,,,,,0.33953,0.38115315437316893,-0.09127,0.1542340693972403,0.12412999999999999,0.24688203469862013,Neutral,Neutral,Neutral,Neutral,Neutral,0.2726975722501425,0.09387725425611183,0.15595499565734058,0.04558,-0.46066,-0.15873321429298917,-0.20754,-0.05657660714649458,Neutral,Neutral,Neutral,Neutral,0.26289429104997064,0.11856052156680609,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.1273,0.9321,-7.9541,-2.49460539608368,0.0012754521597114,Benign,0.3431,ambiguous,-3.216,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M169N,NP_000537:p.Met169Asn,,,,,saturation_mutlist,,,,,,,,1.95848,0.9121339726448059,,1.1588360540102827,,1.5586580270051413,,Neutral,Neutral,,Neutral,0.3508857870572744,,0.3334929599014787,1.1555,,0.900981987128667,,1.0282409935643335,,Neutral,,Neutral,,0.11018100984948072,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.369,0.9321,-22.2419,-6.97309884514643,0.5247185419481961,Uncertain,0.9339,pathogenic,-3.89,available,https://doi.org/10.1101/2022.10.22.513328 +M169P,NP_000537:p.Met169Pro,,,,,saturation_mutlist,,,,,,,,3.13223,1.7769637680053711,,5.065099957395588,,4.098664978697794,,Destabilizing,Uncertain,,Destabilizing,0.3543711063840571,,1.3038466855987914,0.76437,,2.6186563285126296,,1.6915131642563148,,Uncertain,,Neutral,,0.6410814664744159,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.4869,0.9321,-22.2419,-7.21542309947019,0.6361762605733088,Uncertain,0.9904,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328 +M169Q,NP_000537:p.Met169Gln,,,,,saturation_mutlist,,,,,,,,1.18671,0.1731377911567688,,0.9779434175027554,,1.0823267087513777,,Neutral,Neutral,,Neutral,0.28409927017040576,,0.30950388955312075,0.87886,,0.67117251465712,,0.7750162573285599,,Neutral,,Neutral,,0.060298680620706355,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.3611,0.9321,-22.2419,-6.97309884514643,0.1593509397416876,Benign,0.6168,pathogenic,-3.694,available,https://doi.org/10.1101/2022.10.22.513328 +M169R,NP_000537:p.Met169Arg,"hg19,17:g.7578424A>C, hg38,17:g.7675106A>C",,,0.740,"ClinVar,saturation_mutlist",568736,Uncertain significance,1,,,,,1.23377,0.49522947788238525,0.6112266666666667,0.5989692120825453,0.9224983333333334,0.9163696060412727,Neutral,Neutral,Neutral,Neutral,Neutral,0.4395445513217362,0.7331609707894228,0.3259050296473433,0.93676,1.11406,0.4906048767648092,1.02541,0.7136824383824046,Neutral,Neutral,Neutral,Neutral,0.2578427687564652,0.040963402682217924,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,neutral,,-0.3329,0.9321,-7.9541,-4.27667041598335,0.0005118065385488,Benign,0.6324,pathogenic,-3.413,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M169S,NP_000537:p.Met169Ser,,,,,saturation_mutlist,,,,,,,,1.81994,0.7139295935630798,,1.3895559006499856,,1.6047479503249926,,Neutral,Neutral,,Neutral,0.310220678256683,,0.38069148710906814,1.29294,,1.1407569545888274,,1.2168484772944137,,Neutral,,Neutral,,0.09940103722031421,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.3473,0.9321,-22.2419,-5.26013122331273,0.2042207786376711,Benign,0.8511,pathogenic,-3.616,available,https://doi.org/10.1101/2022.10.22.513328 +M169T,NP_000537:p.Met169Thr,"hg19,17:g.7578424A>G, hg19,17:g.7675106A>G, hg38,17:g.7675106A>G",,,0.726,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.82154,0.9165821480751037,1.2363933333333332,1.1181685973731461,1.5289666666666666,1.469854298686573,Neutral,Neutral,Neutral,Neutral,Neutral,0.3640627910307804,0.5874761818907119,0.3486161156588776,1.30134,0.8731300000000001,0.8755012138323462,1.087235,1.088420606916173,Neutral,Neutral,Neutral,Neutral,0.27367964885975715,0.030748834921751497,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.2871,0.9321,-22.2419,-5.6705964229845,0.3075462258504925,Benign,0.7014,pathogenic,-3.497,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M169V,NP_000537:p.Met169Val,"hg19,17:g.7578425T>C, hg38,17:g.7675107T>C",,,0.503,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",844926,Uncertain significance,2,,,,,1.26332,0.7690718626976013,0.43197,0.6765066927294074,0.847645,0.9699133463647037,Neutral,Neutral,Neutral,Neutral,Neutral,0.2956806654641909,0.4065717187245894,0.22151703314037724,1.19106,0.7702966666666667,0.3426680618145072,0.9806783333333333,0.7668640309072536,Neutral,Neutral,Neutral,Neutral,0.2970280693058411,0.10508898633107791,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,uncertain,,-0.1537,0.9321,-0.373,-0.50685064374124,9.488448037917104e-08,Benign,0.1036,benign,-2.812,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M169W,NP_000537:p.Met169Trp,,,,,saturation_mutlist,,,,,,,,2.6154,0.8148856925964355,,-0.005060551522382471,,1.305169724238809,,Uncertain,Neutral,,Neutral,0.43156164375277467,,0.09382470140598921,1.36036,,-0.4144800098690978,,0.47293999506545115,,Neutral,,Neutral,,0.24080737949230885,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,neutral,,-0.3838,0.9321,-22.2419,-5.99304405598151,0.5508821553828736,Uncertain,0.9349,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328 +M169Y,NP_000537:p.Met169Tyr,,,,,saturation_mutlist,,,,,,,,2.73896,0.8383637833595275,,0.5365534023696551,,1.6377567011848275,,Uncertain,Neutral,,Neutral,0.3687944535771548,,0.1849719373266695,1.0104,,0.14006278119669568,,0.5752313905983478,,Neutral,,Neutral,,0.14977280010607819,14.534,11.062,48.685,12.924,,True,14.534,,neutral,neutral,neutral,,True,48.685,,neutral,neutral,neutral,neutral,,-0.3633,0.9321,-22.2419,-5.11695802785901,0.2960674681770635,Benign,0.9203,pathogenic,-3.774,available,https://doi.org/10.1101/2022.10.22.513328 +T170A,NP_000537:p.Thr170Ala,"hg19,17:g.7578422T>C, hg38,17:g.7675104T>C",,,0.518,"COSMIC,ClinVar,saturation_mutlist",135949,Uncertain significance,2,,,,,-0.63037,0.45977612733840945,0.01031666666666666,0.4366574153430676,-0.3100266666666667,-0.09685629232846618,Neutral,Neutral,Neutral,Neutral,Neutral,0.2866588748204052,0.3652612340351613,0.22497796445350912,-1.21476,-0.83356,0.24137096680889236,-1.02416,-0.48669451659555385,Neutral,Neutral,Neutral,Neutral,0.30296192268996447,0.1134406122994984,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.1312,0.9789,-2.3395,-1.63523202592168,2.7914554906054854e-08,Benign,0.2803,benign,-3.019,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T170C,NP_000537:p.Thr170Cys,,,,,saturation_mutlist,,,,,,,,-0.5545,0.292793173789978,,0.8989398220090186,,0.17221991100450929,,Neutral,Neutral,,Neutral,0.18364346193722952,,0.07576744086972224,-0.7485,,0.7205117107631641,,-0.01399414461841797,,Neutral,,Neutral,,0.1506933453587595,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.2686,0.9789,-22.2419,-3.58873454267009,0.3745127351272354,Uncertain,0.8137,pathogenic,-3.82,available,https://doi.org/10.1101/2022.10.22.513328 +T170D,NP_000537:p.Thr170Asp,,,,,saturation_mutlist,,,,,,,,-0.2518,0.9007649385929107,,0.2925750825752061,,0.020387541287603034,,Neutral,Neutral,,Neutral,0.387892920929083,,0.1775515918762801,0.21949,,0.3684320604252583,,0.29396103021262915,,Neutral,,Neutral,,0.08841237130039056,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.3483,0.9789,-22.2419,-4.93597296061548,0.6335371677960596,Uncertain,0.9157,pathogenic,-3.966,available,https://doi.org/10.1101/2022.10.22.513328 +T170E,NP_000537:p.Thr170Glu,,,,,saturation_mutlist,,,,,,,,-0.86586,0.9028724944591522,,0.1138107460386406,,-0.3760246269806797,,Neutral,Neutral,,Neutral,0.32920908775397123,,0.2700320071248142,-0.57663,,0.17951747799814544,,-0.19855626100092727,,Neutral,,Neutral,,0.10654466076360189,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.3236,0.9789,-22.2419,-4.23336195320994,0.0954653957150425,Benign,0.8414,pathogenic,-3.718,available,https://doi.org/10.1101/2022.10.22.513328 +T170F,NP_000537:p.Thr170Phe,,,,,saturation_mutlist,,,,,,,,-1.09497,0.5836609292030335,,-0.4229170698325359,,-0.758943534916268,,Neutral,Neutral,,Neutral,0.26361023682816404,,0.038861541434062945,-0.13134,,-0.4257480628712038,,-0.2785440314356019,,Neutral,,Neutral,,0.09331366871813286,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.34,0.9789,-22.2419,-5.19110274730106,0.3158368324363094,Benign,0.9103,pathogenic,-4.088,available,https://doi.org/10.1101/2022.10.22.513328 +T170G,NP_000537:p.Thr170Gly,,,,,saturation_mutlist,,,,,,,,-0.15602,0.48086094856262207,,1.105453850985093,,0.4747169254925465,,Neutral,Neutral,,Neutral,0.34340118003955744,,0.19523847469417113,-1.0385,,1.1678504724865029,,0.06467523624325144,,Neutral,,Neutral,,0.14321681990510413,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.2384,0.9789,-8.9541,-3.9733966694728,0.0079987080558211,Benign,0.5247,ambiguous,-3.525,available,https://doi.org/10.1101/2022.10.22.513328 +T170H,NP_000537:p.Thr170His,,,,,saturation_mutlist,,,,,,,,-0.39926,0.4396162748336792,,-0.13105064734899766,,-0.26515532367449884,,Neutral,Neutral,,Neutral,0.23999077620275744,,0.07846215401933022,0.51216,,-0.21357788175453027,,0.14929105912273483,,Neutral,,Neutral,,0.034288436742150756,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.3203,0.9789,-22.2419,-4.46118124137844,0.0588190390235162,Benign,0.8188,pathogenic,-3.79,available,https://doi.org/10.1101/2022.10.22.513328 +T170I,NP_000537:p.Thr170Ile,,,,,saturation_mutlist,,,,,,,,-0.77547,0.540548312664032,,-0.19809993402450762,,-0.4867849670122538,,Neutral,Neutral,,Neutral,0.3117006187404708,,0.19903435217482696,-0.17624,,-0.4012402114291262,,-0.2887401057145631,,Neutral,,Neutral,,0.14573295064214292,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.2586,0.9789,-22.2419,-5.08873994947393,0.5547452012373151,Uncertain,0.8872,pathogenic,-3.901,available,https://doi.org/10.1101/2022.10.22.513328 +T170K,NP_000537:p.Thr170Lys,"hg19,17:g.7578421G>T",,,0.827,"cBioPortal,saturation_mutlist",,,,,,,,-1.03495,0.44728091478347776,0.08265333333333334,0.1355046667403144,-0.47614833333333334,-0.44972266662984284,Neutral,Neutral,Neutral,Neutral,Neutral,0.26681516557201196,0.20878769605085024,0.1833804954150534,-0.73303,-0.39195,0.23362565220697307,-0.5624899999999999,-0.24970217389651345,Neutral,Neutral,Neutral,Neutral,0.37717297923720183,0.07749682110431919,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.248,0.9789,-8.9541,-4.11631657448966,0.0034044676136095,Benign,0.7513,pathogenic,-3.782,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T170L,NP_000537:p.Thr170Leu,,,,,saturation_mutlist,,,,,,,,-1.24812,0.582415738105774,,-0.3455410826204844,,-0.7968305413102421,,Neutral,Neutral,,Neutral,0.27668775965040054,,0.17806361080670577,-0.95516,,-0.49309256298110044,,-0.7241262814905502,,Neutral,,Neutral,,0.10214282419602135,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.3106,0.9789,-22.2419,-4.93825803368832,0.1181013369654958,Benign,0.4268,ambiguous,-3.767,available,https://doi.org/10.1101/2022.10.22.513328 +T170M,NP_000537:p.Thr170Met,"hg19,17:g.7578421G>A, hg38,17:g.7675103G>A",3.186336987e-05,4.7747511161e-05,0.868,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",184014,Likely benign,3,,,,,-1.34803,0.6228877902030945,-0.11337666666666664,-0.005980923132199435,-0.7307033333333334,-0.6770054615660998,Neutral,Neutral,Neutral,Neutral,Neutral,0.2463531806120785,0.5868665661138163,0.08179236575998636,-1.35808,-0.6312933333333334,-0.1309294688021232,-0.9946866666666667,-0.7445047344010616,Neutral,Neutral,Neutral,Neutral,0.47948346265075253,0.05188583867002459,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.1995,0.9789,-6.9542,-2.97207536319492,0.0028438986608866,Benign,0.2516,benign,-3.499,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T170N,NP_000537:p.Thr170Asn,,,,,saturation_mutlist,,,,,,,,-0.57965,0.4641256213188171,,0.24129725570132707,,-0.16917637214933645,,Neutral,Neutral,,Neutral,0.2572220279131954,,0.08389732308549586,-0.34997,,0.17340110181943882,,-0.08828444909028059,,Neutral,,Neutral,,0.06275685021613861,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.2884,0.9789,-22.2419,-4.3449282684324,0.0743072165059813,Benign,0.5438,ambiguous,-3.47,available,https://doi.org/10.1101/2022.10.22.513328 +T170P,NP_000537:p.Thr170Pro,"hg38,17:g.7675104T>G",,,0.808,"COSMIC,saturation_mutlist",,,,,,,,-0.92918,0.8079829502105713,3.1512466666666668,2.430429375651294,1.1110333333333333,0.7506246878256468,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.3465050252085567,0.4327188573298936,0.8333013186366033,-0.19343,3.2362800000000003,2.5536223344048845,1.5214250000000002,1.1800961672024424,Uncertain,Uncertain,Neutral,Neutral,1.0193223965295117,1.103367737956934,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.397,0.9789,-22.2419,-5.92405679685997,0.2455088462568569,Benign,0.6747,pathogenic,-3.997,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T170Q,NP_000537:p.Thr170Gln,,,,,saturation_mutlist,,,,,,,,-0.82071,0.6526635241508484,,0.3450421551271277,,-0.23783392243643617,,Neutral,Neutral,,Neutral,0.27296155673602635,,0.1771978916357519,-0.75332,,0.27325565098060517,,-0.2400321745096974,,Neutral,,Neutral,,0.03369368032573709,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.2978,0.9789,-22.2419,-3.93212575064101,0.0435043919668773,Benign,0.6245,pathogenic,-3.663,available,https://doi.org/10.1101/2022.10.22.513328 +T170R,NP_000537:p.Thr170Arg,"hg19,17:g.7578421G>C, hg38,17:g.7675103G>C",,,0.867,"COSMIC,ClinVar,saturation_mutlist",490174,Uncertain significance,2,,,,,-0.88165,0.39211824893951414,0.3149666666666667,-0.0788636095092715,-0.2833416666666667,-0.4802568047546358,Neutral,Neutral,Neutral,Neutral,Neutral,0.2325676012262657,0.21858607600261787,0.19367137962043326,-0.2989,-0.4158733333333333,-0.07033285267937356,-0.35738666666666663,-0.18461642633968678,Neutral,Neutral,Neutral,Neutral,0.5630412543993163,0.05606383937322787,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.3187,0.9789,-22.2419,-4.25530568069192,0.0118087553459044,Benign,0.6801,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T170S,NP_000537:p.Thr170Ser,"hg19,17:g.7578422T>A, hg38,17:g.7675104T>A",,,0.629,"COSMIC,ClinVar,saturation_mutlist",3460324,Uncertain significance,1,,,,,-0.393,0.261637065410614,0.025169999999999998,0.44078511037174994,-0.183915,0.023892555185874964,Neutral,Neutral,Neutral,Neutral,Neutral,0.2220645468750622,0.17572291275376317,0.1417278795562324,-0.58155,-0.34920666666666667,0.38376270089569037,-0.46537833333333334,-0.09889364955215482,Neutral,Neutral,Neutral,Neutral,0.2013516493324276,0.07811903843162857,48.889,15.884,33.135,17.677,,True,48.889,,neutral,,,,True,33.135,,neutral,,,uncertain,,-0.1104,0.9789,-5.3692,-2.03573026158437,2.5391025555328576e-05,Benign,0.4327,ambiguous,-3.127,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T170V,NP_000537:p.Thr170Val,,,,,saturation_mutlist,,,,,,,,-0.49084,0.5523690986633301,,-0.0952780552761116,,-0.2930590276380558,,Neutral,Neutral,,Neutral,0.2643650875200081,,0.142754329224792,-0.17404,,-0.29176168511879724,,-0.23290084255939864,,Neutral,,Neutral,,0.1886306054687553,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.2462,0.9789,-22.2419,-5.15187958193741,0.4969348465075562,Uncertain,0.6648,pathogenic,-3.835,available,https://doi.org/10.1101/2022.10.22.513328 +T170W,NP_000537:p.Thr170Trp,,,,,saturation_mutlist,,,,,,,,-0.79667,0.46128666639328003,,-0.6812889711592344,,-0.7389794855796172,,Neutral,Neutral,,Neutral,0.28910248063327343,,0.09465812523583961,0.47174,,-0.7277281665039311,,-0.12799408325196557,,Neutral,,Neutral,,0.0741819065408987,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.3329,0.9789,-22.2419,-5.19110274730106,0.7188222046554987,Pathogenic,0.9631,pathogenic,-4.368,available,https://doi.org/10.1101/2022.10.22.513328 +T170Y,NP_000537:p.Thr170Tyr,,,,,saturation_mutlist,,,,,,,,-1.00979,0.43523999214172365,,-0.31773606307946933,,-0.6637630315397347,,Neutral,Neutral,,Neutral,0.27822586592786486,,0.052267249912551376,0.12485,,-0.3141127299311129,,-0.09463136496555644,,Neutral,,Neutral,,0.06621735466748843,48.889,15.884,33.135,17.677,,True,48.889,,uncertain,,,,True,33.135,,uncertain,,,uncertain,,-0.3414,0.9789,-22.2419,-4.79566905823871,0.4748619590827574,Uncertain,0.925,pathogenic,-4.052,available,https://doi.org/10.1101/2022.10.22.513328 +E171A,NP_000537:p.Glu171Ala,"hg38,17:g.7675100T>G",,,0.896,"COSMIC,saturation_mutlist",,,,,,,,1.22116,0.6803071641921997,1.0721100000000001,0.7158063643443694,1.146635,0.9684831821721847,Neutral,Neutral,Neutral,Neutral,Neutral,0.19017318547578355,0.19561645653335677,0.36432737222352246,-0.68589,0.08129333333333329,0.4637692548506547,-0.30229833333333334,-0.11106037257467266,Neutral,Neutral,Neutral,Neutral,1.273415153680143,0.21825494561962924,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,uncertain,,-0.272,0.5293,-22.2419,-6.20129813780346,0.8373121047413129,Pathogenic,0.8731,pathogenic,-4.196,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E171C,NP_000537:p.Glu171Cys,,,,,saturation_mutlist,,,,,,,,1.42413,0.12113948106765747,,1.149102464734381,,1.2866162323671904,,Neutral,Neutral,,Neutral,0.19190678560405794,,0.34664390846538057,-0.15362,,0.8799073506282991,,0.36314367531414954,,Neutral,,Neutral,,0.2504163843755258,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,uncertain,,-0.3413,0.5293,-22.2419,-6.20129813780346,0.8483112769064071,Pathogenic,0.9944,pathogenic,-4.558,available,https://doi.org/10.1101/2022.10.22.513328 +E171D,NP_000537:p.Glu171Asp,"hg19,17:g.7578417C>A, hg19,17:g.7578417C>G, hg38,17:g.7675099C>A, hg38,17:g.7675099C>G",,,0.597,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2446885,Pathogenic,0,,,,,0.64685,0.9776002526283264,0.58787,0.7374299149522847,0.61736,0.6921399574761424,Neutral,Neutral,Neutral,Neutral,Neutral,0.21210860702835496,0.3615836379963378,0.31649024957081656,0.00391,-0.08480666666666668,0.7358999253629951,-0.04044833333333334,0.36990496268149753,Neutral,Neutral,Neutral,Neutral,0.34402352674716236,0.16457882427092543,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,uncertain,,-0.1402,0.5293,-3.1468,-1.85058558362392,0.0002006478202313,Benign,0.3892,ambiguous,-3.196,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E171F,NP_000537:p.Glu171Phe,,,,,saturation_mutlist,,,,,,,,1.1312,0.4872730040550232,,0.032449370923678396,,0.5818246854618392,,Neutral,Neutral,,Neutral,0.24910763576779155,,0.2591452431834376,0.8647,,-0.6833375253984051,,0.09068123730079747,,Neutral,,Neutral,,0.26382579826621205,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,neutral,,-0.3189,0.5293,-22.2419,-6.11269247840749,0.8645037634523982,Pathogenic,0.9972,pathogenic,-4.672,available,https://doi.org/10.1101/2022.10.22.513328 +E171G,NP_000537:p.Glu171Gly,"hg19,17:g.7578418T>C, hg38,17:g.7675100T>C",,,0.917,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1745525,Pathogenic,1,,,,,1.96515,0.9114997816085816,1.8734666666666666,1.6600156446411063,1.9193083333333334,1.8125828223205531,Neutral,Neutral,Neutral,Neutral,Neutral,0.3535940118369041,0.6613164498348898,0.35794113827623164,-0.78163,2.06871,1.4920839902528307,0.6435399999999999,0.3552269951264153,Uncertain,Neutral,Neutral,Neutral,1.3036902510182395,0.3410073270115928,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,uncertain,,-0.2977,0.5293,-22.2419,-6.9789271754094,0.8596835406908515,Pathogenic,0.9178,pathogenic,-4.153,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E171H,NP_000537:p.Glu171His,,,,,saturation_mutlist,,,,,,,,1.71171,0.5174295353889465,,0.2809961386827213,,0.9963530693413607,,Neutral,Neutral,,Neutral,0.20674142069835966,,0.36554953485362407,1.6903,,-0.1469858352029805,,0.7716570823985097,,Neutral,,Neutral,,0.16505305669180156,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,neutral,,-0.3102,0.5293,-22.2419,-5.57283775201868,0.3275589846958389,Uncertain,0.9814,pathogenic,-4.166,available,https://doi.org/10.1101/2022.10.22.513328 +E171I,NP_000537:p.Glu171Ile,,,,,saturation_mutlist,,,,,,,,0.72687,0.5817274832725525,,-0.16893280070851965,,0.27896859964574017,,Neutral,Neutral,,Neutral,0.27433860427612916,,0.29091183512370605,0.81013,,-0.2521039186707907,,0.27901304066460464,,Neutral,,Neutral,,0.20346988536486396,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,neutral,,-0.3243,0.5293,-22.2419,-5.68046272627712,0.6877757892867329,Pathogenic,0.9846,pathogenic,-4.461,available,https://doi.org/10.1101/2022.10.22.513328 +E171K,NP_000537:p.Glu171Lys,"hg19,17:g.7578419C>T, hg19,17:g.7675101C>T, hg38,17:g.7675101C>T",,,0.873,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141566,Likely benign,3,,,,,1.37132,0.6026776671409607,1.0512466666666667,0.6255679333842957,1.2112833333333333,0.9984439666921479,Neutral,Neutral,Neutral,Neutral,Neutral,0.19271654902593646,0.12336738475878556,0.4535372884537441,0.52385,0.8472766666666667,0.5040250137089196,0.6855633333333333,0.5139375068544598,Neutral,Neutral,Neutral,Neutral,1.612087241070477,0.20925868004333298,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,neutral,,-0.294,0.5293,-22.2419,-5.44074972072355,0.3133525086165007,Benign,0.926,pathogenic,-4.017,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E171L,NP_000537:p.Glu171Leu,,,,,saturation_mutlist,,,,,,,,0.6471,0.3666825222969055,,-0.15750418039466582,,0.24479790980266708,,Neutral,Neutral,,Neutral,0.24376490161163697,,0.26808598926423827,-0.50165,,-0.6705638711922844,,-0.5861069355961422,,Neutral,,Neutral,,0.20229000043927423,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,neutral,,-0.2586,0.5293,-8.9541,-4.34211159717172,0.038424368418548,Benign,0.976,pathogenic,-4.122,available,https://doi.org/10.1101/2022.10.22.513328 +E171M,NP_000537:p.Glu171Met,,,,,saturation_mutlist,,,,,,,,0.60015,0.3785196661949158,,0.2977425873623106,,0.44894629368115524,,Neutral,Neutral,,Neutral,0.19425304000056623,,0.36667429495435505,-0.84038,,-0.365186449334231,,-0.6027832246671155,,Neutral,,Neutral,,0.17337538860964827,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,neutral,,-0.2753,0.5293,-22.2419,-5.25379652477179,0.8166192332781916,Pathogenic,0.9731,pathogenic,-4.401,available,https://doi.org/10.1101/2022.10.22.513328 +E171N,NP_000537:p.Glu171Asn,,,,,saturation_mutlist,,,,,,,,1.66859,0.7662233328819275,,0.7150177749651282,,1.191803887482564,,Neutral,Neutral,,Neutral,0.18855893011227184,,0.34949212061997104,0.62145,,0.4865462390922542,,0.5539981195461271,,Neutral,,Neutral,,0.3297351466211265,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,uncertain,,-0.2982,0.5293,-22.2419,-3.51262689647183,0.4683069683176472,Uncertain,0.9208,pathogenic,-4.095,available,https://doi.org/10.1101/2022.10.22.513328 +E171P,NP_000537:p.Glu171Pro,,,,,saturation_mutlist,,,,,,,,2.49062,1.949463677406311,,3.8418918410353347,,3.166255920517667,,Uncertain,Uncertain,,Destabilizing,0.39582952750765715,,0.7308113806626799,1.85612,,5.876108142021057,,3.866114071010528,,Uncertain,,Destabilizing,,0.9304061194005707,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,uncertain,,-0.4289,0.5293,-22.2419,-6.9789271754094,0.8667667634642175,Pathogenic,0.9985,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328 +E171Q,NP_000537:p.Glu171Gln,"hg38,17:g.7675101C>G",,,0.849,"COSMIC,saturation_mutlist",,,,,,,,0.67436,0.21666163921356202,0.3840133333333333,0.5459101987547715,0.5291866666666667,0.6101350993773857,Neutral,Neutral,Neutral,Neutral,Neutral,0.17105988777065811,0.0664363787560868,0.35417853658879567,0.66392,-0.80998,0.34474047488724374,-0.07303000000000004,0.5043302374436218,Neutral,Neutral,Neutral,Neutral,0.6322921002722292,0.20869005997583276,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,neutral,,-0.2445,0.5293,-22.2419,-3.43028631755335,0.4445999987901167,Uncertain,0.8251,pathogenic,-3.892,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E171R,NP_000537:p.Glu171Arg,,,,,saturation_mutlist,,,,,,,,1.76631,0.7815825533866883,,0.3933637839213173,,1.0798368919606587,,Neutral,Neutral,,Neutral,0.2093514199581725,,0.4271067472650485,0.97852,,0.006053627899894619,,0.4922868139499473,,Neutral,,Neutral,,0.22246911619339615,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,neutral,,-0.3545,0.5293,-22.2419,-6.16910998387994,0.6827825182287437,Pathogenic,0.9552,pathogenic,-4.291,available,https://doi.org/10.1101/2022.10.22.513328 +E171S,NP_000537:p.Glu171Ser,,,,,saturation_mutlist,,,,,,,,1.56529,0.7787193202972412,,1.0084859477073522,,1.286887973853676,,Neutral,Neutral,,Neutral,0.17391030450821102,,0.3512432067325833,-0.11862,,0.9138453878253648,,0.3976126939126824,,Neutral,,Neutral,,0.24657845359790873,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,uncertain,,-0.2854,0.5293,-22.2419,-5.84841661659109,0.3858493506300259,Uncertain,0.8916,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328 +E171T,NP_000537:p.Glu171Thr,,,,,saturation_mutlist,,,,,,,,1.65182,0.5639509725570678,,0.5786464896084883,,1.1152332448042441,,Neutral,Neutral,,Neutral,0.22854447641801298,,0.33928248439643083,0.57635,,0.5146921642779162,,0.5455210821389581,,Neutral,,Neutral,,0.20621712963640457,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,uncertain,,-0.3013,0.5293,-22.2419,-5.98009043541364,0.3577504317662678,Uncertain,0.9385,pathogenic,-4.148,available,https://doi.org/10.1101/2022.10.22.513328 +E171V,NP_000537:p.Glu171Val,"hg38,17:g.7675099_7675100delinsGA, hg38,17:g.7675100T>A",,,0.922,"COSMIC,saturation_mutlist",,,,,,,,1.10116,0.5956200218200683,0.8426300000000001,-0.036621456584061296,0.971895,0.5322692717079693,Neutral,Neutral,Neutral,Neutral,Neutral,0.22749965295252783,0.7762930942627275,0.25627561658344616,0.76584,-0.5496599999999999,-0.10113154900315631,0.10809000000000002,0.3323542254984218,Neutral,Neutral,Neutral,Neutral,0.9543111311307229,0.2400289910919436,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,uncertain,,-0.2852,0.5293,-22.2419,-4.31924205743371,0.1830653811838435,Benign,0.9389,pathogenic,-4.167,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E171W,NP_000537:p.Glu171Trp,,,,,saturation_mutlist,,,,,,,,1.6797,0.7595169615745544,,-0.24075350824085295,,0.7194732458795735,,Neutral,Neutral,,Neutral,0.28555733771250097,,0.3537229600337753,2.11765,,-0.9972685851409798,,0.56019070742951,,Uncertain,,Neutral,,0.17695194519611854,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,neutral,,-0.329,0.5293,-22.2419,-6.11269247840749,0.838151485614168,Pathogenic,0.9985,pathogenic,-4.803,available,https://doi.org/10.1101/2022.10.22.513328 +E171Y,NP_000537:p.Glu171Tyr,,,,,saturation_mutlist,,,,,,,,1.34477,0.5507518839836121,,0.147391370244186,,0.746080685122093,,Neutral,Neutral,,Neutral,0.28085276712300494,,0.27537700826460193,1.26011,,-0.5393590308139945,,0.3603754845930028,,Neutral,,Neutral,,0.17653009306355122,32.224,9.942,18.585,12.708,,True,32.224,,neutral,neutral,neutral,,True,18.585,,neutral,neutral,neutral,neutral,,-0.3198,0.5293,-22.2419,-5.7872977344495,0.682059763144565,Pathogenic,0.9934,pathogenic,-4.49,available,https://doi.org/10.1101/2022.10.22.513328 +V172A,NP_000537:p.Val172Ala,"hg19,17:g.7578415A>G, hg38,17:g.7675097A>G",,,0.850,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528245,Uncertain significance,1,,,,,1.05794,1.1398166155815124,1.07755,1.129421774147514,1.067745,1.093680887073757,Neutral,Neutral,Uncertain,Neutral,Neutral,0.3354320437128478,0.3020235874894542,0.4654230343640504,-0.41202,1.4492066666666668,1.643145839520823,0.5185933333333334,0.6155629197604114,Neutral,Neutral,Neutral,Neutral,0.15507550856133134,0.1781118187577723,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,uncertain,,-0.2594,0.2583,-8.9541,-4.14941940549315,0.0108297785586636,Benign,0.7232,pathogenic,-3.474,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V172C,NP_000537:p.Val172Cys,,,,,saturation_mutlist,,,,,,,,0.94002,0.7346626687049865,,1.433639076527414,,1.186829538263707,,Neutral,Neutral,,Neutral,0.27298181273159633,,0.35577311505252956,-0.29475,,1.944621015178946,,0.824935507589473,,Neutral,,Neutral,,0.15270402774525052,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,uncertain,,-0.3551,0.2583,-22.2419,-6.0281969995146,0.6795332426518242,Pathogenic,0.9718,pathogenic,-4.153,available,https://doi.org/10.1101/2022.10.22.513328 +V172D,NP_000537:p.Val172Asp,"hg19,17:g.7578415A>T, hg19,17:g.7675097A>T, hg38,17:g.7675097A>T",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",836761,Conflicting classifications of pathogenicity,1,,,,,1.88591,1.8142073774337768,3.203063333333333,1.4464964486108265,2.544486666666667,1.6662032243054132,Uncertain,Neutral,Uncertain,Uncertain,Neutral,0.39519348034534685,0.2562894054688089,0.8064816773783735,0.76335,3.2047633333333336,2.885986696292885,1.9840566666666668,1.8246683481464425,Uncertain,Uncertain,Neutral,Neutral,0.3220943460471723,0.26514684659360177,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,uncertain,,-0.4938,0.2583,-22.2419,-6.47107433973364,0.8192479048304208,Pathogenic,0.9749,pathogenic,-4.461,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V172E,NP_000537:p.Val172Glu,,,,,saturation_mutlist,,,,,,,,1.45817,1.7926739287376403,,1.2394933239339336,,1.3488316619669667,,Neutral,Uncertain,,Neutral,0.43759115845671187,,0.7941093700697514,1.9048,,2.4235015978380523,,2.1641507989190263,,Uncertain,,Uncertain,,0.25692921345220066,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,uncertain,,-0.4511,0.2583,-22.2419,-6.47107433973364,0.7258366335076318,Pathogenic,0.9553,pathogenic,-4.31,available,https://doi.org/10.1101/2022.10.22.513328 +V172F,NP_000537:p.Val172Phe,"hg19,17:g.7578416C>A, hg19,17:g.7675098C>A, hg38,17:g.7675098C>A",,,0.917,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428909,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,3.77541,1.225887544155121,0.9859400000000001,0.3265522180045366,2.380675,2.0509811090022683,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.2900858416715507,0.8692776073269115,0.667422176474744,7.42464,0.7853733333333334,0.8935890687093632,4.105006666666667,4.159114534354682,Uncertain,Uncertain,Destabilizing,Destabilizing,0.8782374090693752,0.7476138554568362,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,neutral,,-0.4044,0.2583,-22.2419,-6.57026057590032,0.8285234603317373,Pathogenic,0.9499,pathogenic,-4.239,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V172G,NP_000537:p.Val172Gly,"hg19,17:g.7578415A>C, hg19,17:g.7675097A>C, hg38,17:g.7675097A>C",,,0.953,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428883,Uncertain significance,1,,,,,1.93666,1.8486444687843322,2.6519266666666668,2.3960542565516096,2.2942933333333335,2.1663571282758047,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.43354734123195493,0.28333027868941607,0.7164700706585586,-0.18551,3.13288,3.2019716734526606,1.4736850000000001,1.5082308367263304,Uncertain,Uncertain,Neutral,Neutral,0.18767470598529432,0.36469972995431876,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,uncertain,,-0.453,0.2583,-22.2419,-7.50111738309872,0.7032589524280239,Pathogenic,0.8569,pathogenic,-4.31,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V172H,NP_000537:p.Val172His,,,,,saturation_mutlist,,,,,,,,4.06639,1.4275377655029298,,0.7976082894826044,,2.4319991447413023,,Uncertain,Uncertain,,Uncertain,0.37940096823766567,,0.6977921931919978,7.18124,,1.6139915420457076,,4.397615771022854,,Uncertain,,Destabilizing,,0.6830633117163267,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,neutral,,-0.4968,0.2583,-22.2419,-6.63881417978547,0.651782729806701,Uncertain,0.9935,pathogenic,-4.299,available,https://doi.org/10.1101/2022.10.22.513328 +V172I,NP_000537:p.Val172Ile,"hg19,17:g.7578416C>T, hg38,17:g.7675098C>T",,,0.645,"COSMIC,ClinVar,saturation_mutlist",825481,Uncertain significance,2,,,,,-0.32811,0.29745872735977175,0.48322,-0.1819909950714621,0.07755499999999999,-0.25505049753573106,Neutral,Neutral,Neutral,Neutral,Neutral,0.29565167457900304,0.5333877637016682,0.1266675491241932,0.3889,0.3451233333333333,0.4141096900125609,0.3670116666666666,0.4015048450062805,Neutral,Neutral,Neutral,Neutral,0.44056761095457553,0.22847440612412928,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,neutral,,-0.175,0.2583,-5.0473,-1.78606063993282,0.0012689668146295,Benign,0.1538,benign,-3.458,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V172K,NP_000537:p.Val172Lys,,,,,saturation_mutlist,,,,,,,,2.2185,1.5923998403549193,,1.294871061686045,,1.7566855308430225,,Uncertain,Uncertain,,Neutral,0.4140399579177277,,0.9343361418032824,3.39156,,2.4757434026581167,,2.933651701329058,,Uncertain,,Uncertain,,0.5958117698391681,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,neutral,,-0.4901,0.2583,-22.2419,-7.50111738309872,0.8583125612510184,Pathogenic,0.9808,pathogenic,-4.493,available,https://doi.org/10.1101/2022.10.22.513328 +V172L,NP_000537:p.Val172Leu,"hg38,17:g.7675098C>G",,,0.815,"COSMIC,saturation_mutlist",,,,,,,,0.50011,0.935449345111847,,-0.11777507608455506,,0.1911674619577225,,Neutral,Neutral,,Neutral,0.3249484355073528,,0.09875556540272364,0.63323,,0.33919835639844553,,0.48621417819922275,,Neutral,,Neutral,,0.09496551605813998,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,neutral,,-0.26,0.2583,-8.9541,-2.31769997335832,0.1190957505289,Benign,0.9284,pathogenic,-3.71,available,https://doi.org/10.1101/2022.10.22.513328 +V172M,NP_000537:p.Val172Met,,,,,saturation_mutlist,,,,,,,,0.2115,1.181457667350769,,0.3905428388411188,,0.3010214194205594,,Neutral,Uncertain,,Neutral,0.32736181216788446,,0.2711220554899297,0.40745,,0.9414241684754443,,0.6744370842377221,,Neutral,,Neutral,,0.23805928000073331,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,neutral,,-0.3369,0.2583,-22.2419,-4.51094561034991,0.784579648811563,Pathogenic,0.8346,pathogenic,-4.098,available,https://doi.org/10.1101/2022.10.22.513328 +V172N,NP_000537:p.Val172Asn,,,,,saturation_mutlist,,,,,,,,1.64105,1.7034993886947631,,0.9448514213829305,,1.2929507106914653,,Neutral,Uncertain,,Neutral,0.43435499099559094,,0.47545313869500133,1.00671,,1.858099191429818,,1.432404595714909,,Neutral,,Neutral,,0.18785825464952674,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,uncertain,,-0.4817,0.2583,-22.2419,-5.92344084955504,0.2964712037998355,Benign,0.9103,pathogenic,-4.048,available,https://doi.org/10.1101/2022.10.22.513328 +V172P,NP_000537:p.Val172Pro,,,,,saturation_mutlist,,,,,,,,0.00516,1.2524191856384277,,2.42709307200292,,1.21612653600146,,Uncertain,Uncertain,,Neutral,0.6999797314216786,,0.5627469001628737,0.0939,,6.287793738870378,,3.190846869435189,,Uncertain,,Destabilizing,,0.906552862390903,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,uncertain,,-0.5316,0.2583,-22.2419,-4.76107805621625,0.1236054865349592,Benign,0.8202,pathogenic,-3.889,available,https://doi.org/10.1101/2022.10.22.513328 +V172Q,NP_000537:p.Val172Gln,,,,,saturation_mutlist,,,,,,,,1.5495,1.5159321784973145,,1.0037648488243118,,1.2766324244121559,,Neutral,Uncertain,,Neutral,0.3696495151677115,,0.5170964417429591,2.20695,,1.7543585393691343,,1.980654269684567,,Uncertain,,Neutral,,0.2775637345050545,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,uncertain,,-0.4617,0.2583,-22.2419,-5.54356968062171,0.7047432573276154,Pathogenic,0.9691,pathogenic,-4.258,available,https://doi.org/10.1101/2022.10.22.513328 +V172R,NP_000537:p.Val172Arg,,,,,saturation_mutlist,,,,,,,,2.79676,1.5899166178703308,,0.815091583050024,,1.805925791525012,,Uncertain,Uncertain,,Neutral,0.38266526558801367,,0.6878587539967052,4.67825,,1.724885399825906,,3.201567699912953,,Uncertain,,Destabilizing,,0.5278496666277438,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,neutral,,-0.5111,0.2583,-22.2419,-7.50111738309872,0.8324630560743803,Pathogenic,0.9689,pathogenic,-4.258,available,https://doi.org/10.1101/2022.10.22.513328 +V172S,NP_000537:p.Val172Ser,,,,,saturation_mutlist,,,,,,,,1.8519,1.4287996411323547,,1.4361973047533023,,1.644048652376651,,Neutral,Uncertain,,Neutral,0.38366467546937333,,0.63474677507646,-0.12532,,2.4875908361851717,,1.181135418092586,,Uncertain,,Neutral,,0.25528489311231867,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,uncertain,,-0.4309,0.2583,-22.2419,-6.11716716831782,0.5199876439087296,Uncertain,0.8663,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +V172T,NP_000537:p.Val172Thr,,,,,saturation_mutlist,,,,,,,,1.14768,0.9673215746879578,,0.9214958684002753,,1.0345879342001376,,Neutral,Neutral,,Neutral,0.27880442104079145,,0.3891147173232494,0.01009,,1.5976296137130472,,0.8038598068565236,,Neutral,,Neutral,,0.10295650685510124,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,uncertain,,-0.2784,0.2583,-8.9541,-5.09449455334904,0.0165052159307684,Benign,0.6829,pathogenic,-3.598,available,https://doi.org/10.1101/2022.10.22.513328 +V172W,NP_000537:p.Val172Trp,,,,,saturation_mutlist,,,,,,,,4.54701,1.3353647875785828,,0.2215805338088188,,2.3842952669044095,,Uncertain,Uncertain,,Uncertain,0.3570104760327285,,0.9068148098361323,13.06291,,1.1140425010692871,,7.088476250534644,,Uncertain,,Destabilizing,,1.0184094689288965,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,neutral,,-0.4449,0.2583,-22.2419,-6.99711620516997,0.846602792519322,Pathogenic,0.9974,pathogenic,-4.573,available,https://doi.org/10.1101/2022.10.22.513328 +V172Y,NP_000537:p.Val172Tyr,,,,,saturation_mutlist,,,,,,,,4.92353,1.3113363361358643,,0.5708186750056533,,2.747174337502827,,Uncertain,Uncertain,,Uncertain,0.3546165236358944,,0.8236300717805112,10.76463,,1.398142151206386,,6.081386075603193,,Uncertain,,Destabilizing,,0.97647775026432,14.86,13.567,3.945,2.562,,True,14.86,,neutral,neutral,neutral,,True,3.945,,neutral,neutral,neutral,neutral,,-0.4478,0.2583,-22.2419,-6.99711620516997,0.838955915607335,Pathogenic,0.9897,pathogenic,-4.468,available,https://doi.org/10.1101/2022.10.22.513328 +V173A,NP_000537:p.Val173Ala,"hg19,17:g.7578412A>G, hg19,17:g.7675094A>G, hg38,17:g.7675094A>G",,,0.758,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376017,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,2.13364,1.1388463163375855,2.2234700000000003,2.5452337133067107,2.1785550000000002,2.3394368566533554,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.3010305377515276,0.2152847732655517,0.2706431024368658,-0.73939,2.293763333333333,1.8637097381957453,0.7771866666666666,0.5621598690978726,Uncertain,Neutral,Neutral,Neutral,0.9623017179773826,0.1967068274876161,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,damaging,,-0.3471,0.042,-22.2419,-7.45707742763203,0.6276495518844947,Uncertain,0.9926,pathogenic,-3.983,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173C,NP_000537:p.Val173Cys,,,,,saturation_mutlist,,,,,,,,1.32375,0.6473431873321533,,2.399755783673727,,1.8617528918368635,,Uncertain,Neutral,,Neutral,0.2492257343566696,,0.09633371318984257,0.23426,,2.182589388228351,,1.2084246941141754,,Uncertain,,Neutral,,0.09841295258645297,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,damaging,,-0.375,0.042,-22.2419,-7.92827937545306,0.8599035716700802,Pathogenic,0.9952,pathogenic,-4.433,available,https://doi.org/10.1101/2022.10.22.513328 +V173D,NP_000537:p.Val173Asp,,,,,saturation_mutlist,,,,,,,,2.46994,1.6322455263137818,,3.7912957792001385,,3.130617889600069,,Uncertain,Uncertain,,Destabilizing,0.319058205357583,,0.2035821863423493,2.65325,,3.526204643775721,,3.0897273218878603,,Uncertain,,Destabilizing,,0.03414835170719977,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,damaging,,-0.5137,0.042,-22.2419,-8.2032647249248,0.8560824997304848,Pathogenic,0.9997,pathogenic,-4.652,available,https://doi.org/10.1101/2022.10.22.513328 +V173E,NP_000537:p.Val173Glu,"hg19,17:g.7578412A>T, hg38,17:g.7675094A>T",,,0.749,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376669,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,2.77599,1.7559156656265258,5.24286,3.607071973830647,4.009425,3.191530986915324,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.3977562337362238,0.5365486773816519,0.1768365295440422,3.88814,5.2822000000000005,3.869819382661022,4.58517,3.8789796913305112,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.108963965603313,0.5084397039073526,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,uncertain,,-0.471,0.042,-22.2419,-8.2032647249248,0.8706375538640991,Pathogenic,0.9987,pathogenic,-4.526,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173F,NP_000537:p.Val173Phe,,,,,saturation_mutlist,,,,,,,,3.75464,1.13382572889328,,1.7322834636264748,,2.7434617318132375,,Uncertain,Uncertain,,Uncertain,0.49594642651468734,,0.4099572833839177,13.71381,,3.2088812807410156,,8.461345640370508,,Destabilizing,,Destabilizing,,1.157714750095196,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,neutral,,-0.4243,0.042,-22.2419,-8.2032647249248,0.8686032996129327,Pathogenic,0.9982,pathogenic,-4.486,available,https://doi.org/10.1101/2022.10.22.513328 +V173G,NP_000537:p.Val173Gly,"hg19,17:g.7578412A>C, hg19,17:g.7675094A>C, hg38,17:g.7675094A>C",,,0.769,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376016,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,3.13531,1.8309247970581055,5.0253966666666665,4.568414632205627,4.080353333333333,3.851862316102814,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.374650809423751,0.3788159044824924,0.28402009187725846,0.00634,4.151016666666667,3.889807622295917,2.0786783333333334,1.9480738111479583,Uncertain,Uncertain,Uncertain,Neutral,0.2683647662334897,0.4445855352433344,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,damaging,,-0.4729,0.042,-22.2419,-8.2032647249248,0.8666219235926084,Pathogenic,0.9863,pathogenic,-4.476,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173H,NP_000537:p.Val173His,,,,,saturation_mutlist,,,,,,,,4.8179,1.669151358604431,,2.721941978388602,,3.7699209891943006,,Uncertain,Uncertain,,Destabilizing,0.4068004115756091,,0.29703842164548383,11.42038,,3.4925521439749665,,7.456466071987483,,Destabilizing,,Destabilizing,,0.8177877953953622,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,neutral,,-0.5167,0.042,-22.2419,-8.2032647249248,0.8652570263269959,Pathogenic,0.9998,pathogenic,-4.605,available,https://doi.org/10.1101/2022.10.22.513328 +V173I,NP_000537:p.Val173Ile,,,,,saturation_mutlist,,,,,,,,0.24269,0.009054627418518065,,0.2419910807060742,,0.2423405403530371,,Neutral,Neutral,,Neutral,0.28576365558340994,,0.20427193343552472,0.96977,,1.6415398128918088,,1.3056549064459044,,Neutral,,Neutral,,1.0031772224138378,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,neutral,,-0.2827,0.042,-22.2419,-4.69066437486283,0.0797206325882215,Benign,0.6823,pathogenic,-3.558,available,https://doi.org/10.1101/2022.10.22.513328 +V173K,NP_000537:p.Val173Lys,,,,,saturation_mutlist,,,,,,,,4.4598,1.693692569732666,,4.266427335088828,,4.363113667544415,,Destabilizing,Uncertain,,Destabilizing,0.38507866779059857,,0.13799047549405666,7.10024,,6.683852089998667,,6.892046044999334,,Destabilizing,,Destabilizing,,0.9911136324700379,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,neutral,,-0.51,0.042,-22.2419,-8.2032647249248,0.8660616517158137,Pathogenic,0.9991,pathogenic,-4.636,available,https://doi.org/10.1101/2022.10.22.513328 +V173L,NP_000537:p.Val173Leu,"hg19,17:g.7578413C>A, hg19,17:g.7578413C>G, hg19,17:g.7675095C>A, hg19,17:g.7675095C>G, hg38,17:g.7675095C>A, hg38,17:g.7675095C>G",,,0.880,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2185665, 376668","Conflicting classifications of pathogenicity, Pathogenic/Likely pathogenic","1, 2","Oncogenic, Oncogenic","1, 1",Tier III - Unknown,1,0.20545,0.2876782155036926,2.25374,0.9243411411761726,1.229595,0.5648955705880863,Uncertain,Neutral,Neutral,Neutral,Neutral,0.38458394542125734,0.6080710952402414,0.11252296496889208,1.88289,3.204876666666667,1.8563307277901002,2.5438833333333335,1.86961036389505,Uncertain,Neutral,Uncertain,Neutral,0.23795197573366675,0.9319056696651009,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,neutral,,-0.2799,0.042,-8.9541,-4.92238514285954,0.18337153375386,Benign,0.9942,pathogenic,-3.778,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173M,NP_000537:p.Val173Met,"hg19,17:g.7578413C>T, hg19,17:g.7675095C>T, hg38,17:g.7675095C>T",,,0.892,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",233951,Pathogenic,3,Oncogenic,1,,,0.43371,0.855936942100525,3.127776666666667,1.7917566080017788,1.7807433333333336,1.1127333040008893,Uncertain,Neutral,Neutral,Neutral,Neutral,0.46669354182417383,1.3278122902562528,0.19994191655539426,2.50181,3.7596399999999996,2.2191047406417073,3.130725,2.3604573703208533,Uncertain,Uncertain,Destabilizing,Uncertain,0.6580004674770377,0.8669353206999951,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,neutral,,-0.289,0.042,-8.9541,-4.92238514285954,0.8355857013153355,Pathogenic,0.9974,pathogenic,-4.18,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173N,NP_000537:p.Val173Asn,,,,,saturation_mutlist,,,,,,,,2.23356,1.7023486399650574,,2.5864947074588414,,2.410027353729421,,Uncertain,Uncertain,,Uncertain,0.3313252152794051,,0.06590711287799779,2.2368,,2.4040874719786487,,2.3204437359893246,,Uncertain,,Uncertain,,0.2031916938717381,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,damaging,,-0.5016,0.042,-22.2419,-8.2032647249248,0.8698594361961508,Pathogenic,0.9992,pathogenic,-4.558,available,https://doi.org/10.1101/2022.10.22.513328 +V173P,NP_000537:p.Val173Pro,,,,,saturation_mutlist,,,,,,,,0.58854,1.0186345314979552,,5.060772971236389,,2.8246564856181946,,Uncertain,Uncertain,,Uncertain,0.4829316001558231,,0.34292924056836194,-1.84668,,6.276156062144023,,2.2147380310720113,,Uncertain,,Uncertain,,0.41303137188917854,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,damaging,,-0.5515,0.042,-22.2419,-8.2032647249248,0.8706754345595297,Pathogenic,0.9825,pathogenic,-4.568,available,https://doi.org/10.1101/2022.10.22.513328 +V173Q,NP_000537:p.Val173Gln,"hg19,17:g.7578412_7578413delinsTG",,,,"cBioPortal,saturation_mutlist",,,,,,,,3.05374,1.6771723794937134,4.169046666666667,2.774235093743236,3.611393333333333,2.913987546871618,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,0.40096069002447776,0.8385591866343656,0.10354695858565613,4.72142,3.9846966666666668,3.076885707444603,4.353058333333333,3.8991528537223017,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.524262754753971,0.5189128688106333,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,uncertain,,-0.4816,0.042,-22.2419,-8.2032647249248,0.8704965255436059,Pathogenic,0.9983,pathogenic,-4.513,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173R,NP_000537:p.Val173Arg,"hg19,17:g.7578412_7578413delinsCT",,,,"cBioPortal,saturation_mutlist",,,,,,,,6.14468,1.856111571788788,6.888323333333333,3.3165708198444883,6.516501666666667,4.7306254099222445,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.4083223356371833,0.3589679757613793,0.2306312762868004,11.62871,9.693086666666668,5.804408037341269,10.660898333333334,8.716559018670635,Destabilizing,Destabilizing,Destabilizing,Destabilizing,1.046766376874781,1.1430731752648204,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,neutral,,-0.531,0.042,-22.2419,-8.2032647249248,0.8679917307216993,Pathogenic,0.9955,pathogenic,-4.574,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173S,NP_000537:p.Val173Ser,,,,,saturation_mutlist,,,,,,,,2.79403,1.6143084716796876,,3.3295057102410492,,3.0617678551205243,,Uncertain,Uncertain,,Destabilizing,0.36743809199813526,,0.195575885010893,0.8708,,2.9258902813654566,,1.8983451406827283,,Uncertain,,Neutral,,0.1813795163625867,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,damaging,,-0.4508,0.042,-22.2419,-7.92827937545306,0.8691313114589929,Pathogenic,0.9936,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +V173T,NP_000537:p.Val173Thr,,,,,saturation_mutlist,,,,,,,,1.71048,1.3876164865493774,,2.0494528990260386,,1.8799664495130193,,Uncertain,Uncertain,,Neutral,0.2882278393590625,,0.07966833894298134,0.81727,,2.2386825345275594,,1.5279762672637798,,Uncertain,,Neutral,,0.2478499456284463,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,damaging,,-0.3662,0.042,-22.2419,-7.92827937545306,0.8707680835818348,Pathogenic,0.9878,pathogenic,-4.237,available,https://doi.org/10.1101/2022.10.22.513328 +V173W,NP_000537:p.Val173Trp,"hg38,17:g.7675094_7675095delinsCA",,,,"COSMIC,saturation_mutlist",,,,,,,,7.84875,1.2324069380760192,7.606346666666667,2.8183524172777283,7.727548333333333,5.333551208638864,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.45472080168364526,2.464224977098389,0.48239448612583513,22.04155,9.63209,4.942767270276863,15.83682,13.492158635138432,Destabilizing,Destabilizing,Destabilizing,Destabilizing,2.9396487678746017,1.3902436846647634,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,neutral,,-0.4648,0.042,-22.2419,-8.2032647249248,0.8683166845262927,Pathogenic,0.9999,pathogenic,-4.706,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173Y,NP_000537:p.Val173Tyr,,,,,saturation_mutlist,,,,,,,,5.26311,1.3734377527236938,,2.5056943204437356,,3.884402160221868,,Uncertain,Uncertain,,Destabilizing,0.4725347408095202,,0.44277380073701406,17.03152,,4.365919321071804,,10.698719660535902,,Destabilizing,,Destabilizing,,1.2347566175493523,7.345,4.11,1.17,1.663,,True,7.345,,neutral,neutral,neutral,,True,1.17,,neutral,neutral,neutral,neutral,,-0.4677,0.042,-22.2419,-8.2032647249248,0.8619052369021458,Pathogenic,0.9996,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328 +R174A,NP_000537:p.Arg174Ala,,,,,saturation_mutlist,,,,,,,,0.71395,1.2435365009307862,,1.1394352760877375,,0.9266926380438687,,Neutral,Uncertain,,Neutral,0.3767280217105255,,0.33798695736631135,-0.40621,,0.8083082523249624,,0.2010491261624812,,Neutral,,Neutral,,0.3491142915828305,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.3081,1.1062,-22.2419,-4.72992187798467,0.3665833124970366,Uncertain,0.9391,pathogenic,-4.063,available,https://doi.org/10.1101/2022.10.22.513328 +R174C,NP_000537:p.Arg174Cys,,,,,saturation_mutlist,,,,,,,,0.49492,1.183848123550415,,1.485973488278308,,0.990446744139154,,Neutral,Uncertain,,Neutral,0.41049081005404875,,0.37509272922606995,-0.4385,,1.3158191821819039,,0.43865959109095193,,Neutral,,Neutral,,0.2759027813795274,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.317,1.1062,-22.2419,-5.48056831453056,0.1838537252419541,Benign,0.5178,ambiguous,-3.971,available,https://doi.org/10.1101/2022.10.22.513328 +R174D,NP_000537:p.Arg174Asp,,,,,saturation_mutlist,,,,,,,,1.74195,2.2553595304489136,,1.6015288880490377,,1.671739444024519,,Neutral,Destabilizing,,Neutral,0.5504961491583346,,0.34265901820708194,0.62425,,1.3428771780542281,,0.983563589027114,,Neutral,,Neutral,,0.5459538256180865,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.3991,1.1062,-22.2419,-5.13791349909677,0.6032543399281365,Uncertain,0.9914,pathogenic,-4.303,available,https://doi.org/10.1101/2022.10.22.513328 +R174E,NP_000537:p.Arg174Glu,"hg19,17:g.7578409_7578410delinsTC",,,,"cBioPortal,saturation_mutlist",,,,,,,,1.31585,2.0432702827453615,2.4861666666666666,1.3403995501463017,1.9010083333333334,1.3281247750731509,Uncertain,Neutral,Destabilizing,Neutral,Neutral,0.5464678965692086,0.19427834264843388,0.43904250715636417,0.34254,1.14161,1.0810279606899769,0.742075,0.7117839803449885,Neutral,Neutral,Neutral,Neutral,0.589232817540458,0.48350785021045745,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.3444,1.1062,-22.2419,-4.63478741191056,0.058597875804278,Benign,0.9157,pathogenic,-3.924,available,https://doi.org/10.1101/2022.10.22.513328 +R174F,NP_000537:p.Arg174Phe,,,,,saturation_mutlist,,,,,,,,0.67998,1.2641674089431763,,0.6833918781534614,,0.6816859390767307,,Neutral,Uncertain,,Neutral,0.4048213073872883,,0.17496963357178763,1.62776,,0.23029239718488914,,0.9290261985924446,,Neutral,,Neutral,,0.33815654987353594,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.3403,1.1062,-22.2419,-5.76486560057875,0.512784914601213,Uncertain,0.9662,pathogenic,-4.338,available,https://doi.org/10.1101/2022.10.22.513328 +R174G,NP_000537:p.Arg174Gly,"hg19,17:g.7578410T>C, hg38,17:g.7675092T>C",,,0.724,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",219487,Uncertain significance,2,,,,,0.88084,1.4009053134918212,2.2202966666666666,1.999076736187763,1.5505683333333333,1.4399583680938814,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.458232158506746,0.46685334666133527,0.15908079901521063,-0.77976,0.7010200000000001,1.6948881633658486,-0.03936999999999996,0.4575640816829243,Neutral,Neutral,Neutral,Neutral,1.0862170353110836,0.4267475451331727,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.3435,1.1062,-22.2419,-6.76261649386947,0.4914079234965727,Uncertain,0.8976,pathogenic,-4.201,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174H,NP_000537:p.Arg174His,,,,,"COSMIC,saturation_mutlist",,,,,,,,1.43779,1.1728504490852356,0.9538566666666667,0.821019209368111,1.1958233333333332,1.1294046046840553,Neutral,Neutral,Uncertain,Neutral,Neutral,0.3328914376072061,0.6358794330863533,0.26263087186110523,1.36254,0.29977333333333334,0.3999199075200304,0.8311566666666668,0.8812299537600152,Neutral,Neutral,Neutral,Neutral,0.580491185481935,0.3826321529287066,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.2778,1.1062,-22.2419,-5.18977860616817,0.0137402385614702,Benign,0.4461,ambiguous,-3.666,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174I,NP_000537:p.Arg174Ile,,,,,saturation_mutlist,,,,,,,,0.51476,1.3656215381622314,,0.6272314728040189,,0.5709957364020095,,Neutral,Uncertain,,Neutral,0.4659317227090068,,0.44257153853562026,0.19424,,0.36283149916602664,,0.2785357495830133,,Neutral,,Neutral,,0.12170274496618029,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.2697,1.1062,-8.9541,-4.16514624065316,0.0195735368174557,Benign,0.8266,pathogenic,-3.88,available,https://doi.org/10.1101/2022.10.22.513328 +R174K,NP_000537:p.Arg174Lys,"hg19,17:g.7578409C>T, hg38,17:g.7675091C>T",,,0.381,"COSMIC,ClinVar,saturation_mutlist",423887,Likely benign,2,,,,,0.16775,0.39394357681274417,1.07585,1.0149346670626904,0.6218,0.5913423335313452,Neutral,Neutral,Neutral,Neutral,Neutral,0.1589096759048097,0.8156761924113434,0.30350930937454745,-0.20618,0.42868666666666666,0.984242279745442,0.11125333333333333,0.389031139872721,Neutral,Neutral,Neutral,Neutral,0.8983971327623188,0.2587196593112023,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.0882,1.1062,-0.6596,-0.580394831201181,6.672566297598946e-10,Benign,0.1746,benign,-2.805,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174L,NP_000537:p.Arg174Leu,,,,,saturation_mutlist,,,,,,,,-0.06193,1.4061631178855896,,0.2582289214303082,,0.0981494607151541,,Neutral,Uncertain,,Neutral,0.44952914980367215,,0.3459915100370909,-0.84205,,-0.1003512931243102,,-0.4712006465621551,,Neutral,,Neutral,,0.22693701930185062,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.2284,1.1062,-6.1468,-3.65349349166278,0.0016282937568124,Benign,0.7229,pathogenic,-3.602,available,https://doi.org/10.1101/2022.10.22.513328 +R174M,NP_000537:p.Arg174Met,"hg38,17:g.7675091C>A",,,0.628,"COSMIC,saturation_mutlist",,,,,,,,-0.22107,1.1757748126983643,0.78934,0.6924320296784013,0.284135,0.23568101483920068,Neutral,Neutral,Uncertain,Neutral,Neutral,0.38625137544112587,0.25949998034682004,0.3889221100074183,-1.17718,-0.4933133333333333,0.27143204164372464,-0.8352466666666666,-0.45287397917813765,Neutral,Neutral,Neutral,Neutral,0.2127734327609744,0.29359041130585795,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.2764,1.1062,-22.2419,-5.36599101832737,0.1173513300980949,Benign,0.8398,pathogenic,-3.987,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174N,NP_000537:p.Arg174Asn,"hg19,17:g.7578408_7578409delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,0.70487,1.4494193840026854,2.2466000000000004,1.0266343560616953,1.4757350000000002,0.8657521780308477,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.38356472697026334,0.6449207286170914,0.3377789548819445,-0.03548,0.37392333333333333,0.748360917767683,0.16922166666666666,0.3564404588838415,Neutral,Neutral,Neutral,Neutral,0.4886454888316841,0.43413127403347396,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.323,1.1062,-22.2419,-5.17496189296656,0.0157746898877589,Benign,0.9769,pathogenic,-3.785,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174P,NP_000537:p.Arg174Pro,,,,,saturation_mutlist,,,,,,,,2.17312,2.079827780723572,,3.0390296906630785,,2.6060748453315394,,Uncertain,Destabilizing,,Uncertain,0.6686886417813352,,0.07701210871331758,3.09574,,2.933930705980419,,3.0148353529902097,,Uncertain,,Destabilizing,,1.0401818159199947,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.4502,1.1062,-22.2419,-6.76261649386947,0.6374389555567551,Uncertain,0.9894,pathogenic,-4.378,available,https://doi.org/10.1101/2022.10.22.513328 +R174Q,NP_000537:p.Arg174Gln,,,,,saturation_mutlist,,,,,,,,0.26137,1.1806307005882264,,1.0069464766319909,,0.6341582383159954,,Neutral,Uncertain,,Neutral,0.3977233975793318,,0.3963839433258656,-0.18615,,0.8883133110584343,,0.3510816555292171,,Neutral,,Neutral,,0.34641283528970856,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.215,1.1062,-8.9541,-3.1896095242181,0.0012307020225878,Benign,0.3163,benign,-3.462,available,https://doi.org/10.1101/2022.10.22.513328 +R174S,NP_000537:p.Arg174Ser,"hg19,17:g.7578408C>G, hg38,17:g.7675090C>A, hg38,17:g.7675090C>G",,,0.639,"COSMIC,ClinVar,saturation_mutlist",1058186,Uncertain significance,2,,,,,0.43545,1.2180088138580323,1.6793666666666667,1.3499648888550457,1.0574083333333333,0.8927074444275229,Neutral,Neutral,Uncertain,Neutral,Neutral,0.41038242025964033,0.5472304865613961,0.25228479563770356,-0.13179,0.44943333333333335,1.0687913156999376,0.1588216666666667,0.4685006578499688,Neutral,Neutral,Neutral,Neutral,0.8894673212034767,0.37055386880028723,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.2408,1.1062,-8.9541,-3.60738461544447,0.022393961740522,Benign,0.9558,pathogenic,-3.76,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174T,NP_000537:p.Arg174Thr,"hg19,17:g.7578409C>G",,,0.633,"cBioPortal,saturation_mutlist",,,,,,,,0.7341,1.2134413051605224,1.0766433333333334,1.081679008281302,0.9053716666666667,0.907889504140651,Neutral,Neutral,Uncertain,Neutral,Neutral,0.45568329723581774,0.40055088168948305,0.33709604175698404,0.53029,-0.21904666666666664,0.9365228182018298,0.1556216666666667,0.7334064091009149,Neutral,Neutral,Neutral,Neutral,0.6832985214547316,0.3147643270043614,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.313,1.1062,-22.2419,-4.42681812986421,0.0067137816840347,Benign,0.8583,pathogenic,-3.728,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174V,NP_000537:p.Arg174Val,,,,,saturation_mutlist,,,,,,,,0.74881,1.3875810265541078,,0.6898751604926873,,0.7193425802463436,,Neutral,Uncertain,,Neutral,0.5037601335722097,,0.4107931177623196,0.18599,,0.4910030889537022,,0.33849654447685107,,Neutral,,Neutral,,0.1536533896332679,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.2568,1.1062,-8.9541,-5.04406001025876,0.0510996475633867,Benign,0.8273,pathogenic,-3.892,available,https://doi.org/10.1101/2022.10.22.513328 +R174W,NP_000537:p.Arg174Trp,"hg19,17:g.7578410T>A, hg19,17:g.7675092T>A, hg38,17:g.7675092T>A",,,0.634,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",964680,Uncertain significance,1,,,,,1.27546,1.307388620376587,0.9346966666666668,0.513948015269076,1.1050783333333334,0.8947040076345381,Neutral,Neutral,Uncertain,Neutral,Neutral,0.47668699098058825,0.38176448117771367,0.1975379637985492,2.3521,-0.24059000000000005,0.05121540405821523,1.055755,1.2016577020291077,Uncertain,Uncertain,Neutral,Neutral,0.8897127599774359,0.3987509492296477,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.3258,1.1062,-22.2419,-5.76486560057875,0.7016290767739689,Pathogenic,0.7385,pathogenic,-4.242,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174Y,NP_000537:p.Arg174Tyr,,,,,saturation_mutlist,,,,,,,,1.23705,1.2626256680488586,,0.8086333097086662,,1.022841654854333,,Neutral,Uncertain,,Neutral,0.4100018351848377,,0.16884733176460745,2.06328,,0.4302676981043759,,1.2467738490521878,,Uncertain,,Neutral,,0.31895805079691375,36.309,12.888,35.85,10.832,,True,36.309,,neutral,neutral,neutral,,True,35.85,,neutral,neutral,neutral,uncertain,,-0.3296,1.1062,-22.2419,-5.38008969887271,0.4425989469620988,Uncertain,0.9223,pathogenic,-4.114,available,https://doi.org/10.1101/2022.10.22.513328 +R175A,NP_000537:p.Arg175Ala,,,,,saturation_mutlist,,,,,,,,0.25062,-0.12166633903980255,,1.4611994292556156,,0.8559097146278078,,Neutral,Neutral,,Neutral,0.42220939306607663,,0.12086216171023442,-6.26101,,0.8184032234806056,,-2.721303388259697,,Uncertain,,Uncertain,,0.36747116257562623,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.4005,0.1023,-22.2419,-6.55462687626449,0.7557877418565699,Pathogenic,0.9957,pathogenic,-4.308,available,https://doi.org/10.1101/2022.10.22.513328 +R175C,NP_000537:p.Arg175Cys,"hg19,17:g.7578407G>A, hg19,17:g.7675089G>A, hg38,17:g.7675089G>A",3.18613394507e-05,1.59182438993e-05,0.833,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",245851,Uncertain significance,3,,,,,0.0869,-0.5389821124076843,0.3914933333333333,1.646581778381325,0.23919666666666667,0.8667408891906625,Neutral,Neutral,Neutral,Neutral,Neutral,0.4485567400939084,1.5804058508356502,0.22567926846711556,-5.29931,0.6561233333333333,1.156718328735992,-2.3215933333333334,-2.071295835632004,Uncertain,Uncertain,Uncertain,Uncertain,0.5924582199802972,0.22816840294690546,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.4093,0.1023,-22.2419,-2.9230705029414,3.6822646623389545e-05,Benign,0.9186,pathogenic,-3.643,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R175D,NP_000537:p.Arg175Asp,,,,,saturation_mutlist,,,,,,,,0.41141,0.5009897275269032,,2.7934508437813244,,1.6024304218906622,,Uncertain,Neutral,,Neutral,0.42231596266559074,,0.06466053056082072,-1.85677,,1.8388220448978105,,-0.008973977551094747,,Neutral,,Neutral,,0.264504337531002,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.4915,0.1023,-22.2419,-7.61120498653563,0.8013447186274274,Pathogenic,0.9996,pathogenic,-4.629,available,https://doi.org/10.1101/2022.10.22.513328 +R175E,NP_000537:p.Arg175Glu,,,,,saturation_mutlist,,,,,,,,1.33733,0.5257162433862687,,2.3620440978507733,,1.8496870489253867,,Uncertain,Neutral,,Neutral,0.452801324278646,,0.1310148891319656,-0.84867,,1.61194066725713,,0.38163533362856494,,Neutral,,Neutral,,0.1947615163626369,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.4368,0.1023,-22.2419,-7.61120498653563,0.5684115075558539,Uncertain,0.9975,pathogenic,-4.567,available,https://doi.org/10.1101/2022.10.22.513328 +R175F,NP_000537:p.Arg175Phe,,,,,saturation_mutlist,,,,,,,,3.24064,-0.010242395997047415,,0.4759507694769636,,1.8582953847384818,,Uncertain,Neutral,,Neutral,0.3366500674167346,,0.25600091301027367,9.61307,,0.14423598825303044,,4.878652994126515,,Uncertain,,Destabilizing,,0.5559196274329882,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,neutral,,-0.4326,0.1023,-22.2419,-6.99788038686524,0.7528685102312314,Pathogenic,0.9995,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328 +R175G,NP_000537:p.Arg175Gly,"hg19,17:g.7578407G>C, hg19,17:g.7675089G>C, hg38,17:g.7675089G>C",,,0.829,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376649,Pathogenic,3,Oncogenic,1,,,0.57493,0.09077447533607483,2.2540833333333334,2.867146237128697,1.4145066666666668,1.7210381185643486,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.3016397827784851,1.0021120180010927,0.11873904359399201,-6.65208,2.31508,2.1876446098995848,-2.1685,-2.2322176950502075,Uncertain,Uncertain,Uncertain,Uncertain,0.2967324789548098,0.20783762222358684,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.4358,0.1023,-22.2419,-7.87534951410341,0.7317191252905382,Pathogenic,0.9953,pathogenic,-4.462,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R175H,NP_000537:p.Arg175His,"hg19,17:g.7578405_7578406delinsAT, hg19,17:g.7578406C>T, hg19,17:g.7675088C>T, hg38,17:g.7675088C>T",,3.9796876741e-06,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12374,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,3.46111,0.08535353243350981,1.2938766666666666,1.2406649308039428,2.3774933333333332,2.3508874654019714,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.24564538074807096,2.37662852882444,0.23836878389284857,6.64887,0.9945566666666666,0.7369180723655031,3.8217133333333333,3.6928940361827514,Uncertain,Uncertain,Destabilizing,Destabilizing,0.3955797647616583,0.3944620864742858,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.2906,0.1023,-6.6322,-4.07240332268089,0.0026003506839338,Benign,0.9857,pathogenic,-3.658,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R175I,NP_000537:p.Arg175Ile,,,,,saturation_mutlist,,,,,,,,0.18307,-0.16269485592842103,,0.25354790476822137,,0.2183089523841107,,Neutral,Neutral,,Neutral,0.5874536515051599,,0.18390290073734586,-1.6889,,0.28423350400129127,,-0.7023332479993544,,Neutral,,Neutral,,0.055803049096690927,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.4299,0.1023,-22.2419,-7.34706045896784,0.5849863638265376,Uncertain,0.9939,pathogenic,-4.471,available,https://doi.org/10.1101/2022.10.22.513328 +R175K,NP_000537:p.Arg175Lys,,,,,saturation_mutlist,,,,,,,,-0.89385,-0.06840843975543975,,1.7464607489232769,,0.4263053744616384,,Neutral,Neutral,,Neutral,0.120190001315135,,0.4276279768923388,-1.5029,,1.6664294022567245,,0.08176470112836232,,Neutral,,Neutral,,0.5505291424406484,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,uncertain,,-0.2907,0.1023,-22.2419,-4.72832862028865,0.532865516440628,Uncertain,0.9728,pathogenic,-3.912,available,https://doi.org/10.1101/2022.10.22.513328 +R175L,NP_000537:p.Arg175Leu,"hg19,17:g.7578406C>A, hg19,17:g.7675088C>A, hg38,17:g.7675088C>A",,,0.960,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182963,Likely pathogenic,3,,,,,-1.5264,-0.5360838663578034,-1.2283433333333333,-0.19922629726594185,-1.3773716666666667,-0.8628131486329709,Neutral,Neutral,Neutral,Neutral,Neutral,0.7844247220727362,1.37570958578554,0.3363942412042515,-2.39537,-0.07585000000000004,-0.053903424717859166,-1.23561,-1.2246367123589297,Uncertain,Uncertain,Neutral,Neutral,0.719495826997396,0.2033254218253715,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.4029,0.1023,-22.2419,-7.34706045896784,0.8105074130572403,Pathogenic,0.9907,pathogenic,-4.308,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R175M,NP_000537:p.Arg175Met,,,,,saturation_mutlist,,,,,,,,-1.36811,-0.2607311618328094,,0.4535965034385346,,-0.4572567482807327,,Neutral,Neutral,,Neutral,0.4335028510362033,,0.3268633243508622,-3.5384,,0.18892671594894037,,-1.6747366420255299,,Uncertain,,Neutral,,0.24653137327544622,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.3688,0.1023,-22.2419,-6.69015758080641,0.4882548951975969,Uncertain,0.999,pathogenic,-4.286,available,https://doi.org/10.1101/2022.10.22.513328 +R175N,NP_000537:p.Arg175Asn,,,,,saturation_mutlist,,,,,,,,0.1954,0.2144597715139389,,1.5505637178805387,,0.8729818589402694,,Neutral,Neutral,,Neutral,0.3438420786199602,,0.1676363672982536,-2.38131,,0.965782659938632,,-0.707763670030684,,Uncertain,,Neutral,,0.24709814876955152,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.4154,0.1023,-22.2419,-7.61120498653563,0.8135016207819172,Pathogenic,0.9985,pathogenic,-4.43,available,https://doi.org/10.1101/2022.10.22.513328 +R175P,NP_000537:p.Arg175Pro,"hg38,17:g.7675088C>G",,,0.966,"COSMIC,saturation_mutlist",,,,,,,,-0.81976,-0.22850192725658416,0.04432999999999998,3.9564474558346547,-0.38771500000000003,1.5683437279173273,Neutral,Uncertain,Neutral,Neutral,Neutral,0.3968535950643914,2.1664905349589385,1.0307875665965258,-5.01139,2.07347,3.4596785731331416,-1.4689599999999998,-0.775855713433429,Uncertain,Uncertain,Neutral,Neutral,1.3777289743148564,1.8647394486384101,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.4747,0.1023,-8.9541,-7.87534951410341,0.0379669720197514,Benign,0.9906,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R175Q,NP_000537:p.Arg175Gln,,,,,saturation_mutlist,,,,,,,,0.48199,0.0648195832967758,,1.341295612235177,,0.9116428061175884,,Neutral,Neutral,,Neutral,0.24429864594294887,,0.25560652587137306,-1.59487,,0.9767917860712929,,-0.30903910696435355,,Neutral,,Neutral,,0.13957939400987374,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.3752,0.1023,-22.2419,-7.29394435525091,0.3424605894188586,Uncertain,0.9764,pathogenic,-4.011,available,https://doi.org/10.1101/2022.10.22.513328 +R175S,NP_000537:p.Arg175Ser,"hg19,17:g.7578407G>T, hg38,17:g.7675089G>T",,,0.831,"COSMIC,ClinVar,saturation_mutlist",4189264,Conflicting classifications of pathogenicity,1,,,,,0.40082,0.04935024797916413,1.2106566666666667,2.1363381731794617,0.8057383333333333,1.2685790865897308,Neutral,Uncertain,Neutral,Neutral,Neutral,0.30670495699538275,1.7908934080384449,0.08350781909201517,-5.92651,1.38322,1.4259843351014452,-2.2716450000000004,-2.2502628324492777,Uncertain,Uncertain,Uncertain,Uncertain,0.8270496503838206,0.21941750665905527,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.401,0.1023,-22.2419,-6.55462687626449,0.532830462460785,Uncertain,0.9988,pathogenic,-4.155,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R175T,NP_000537:p.Arg175Thr,,,,,saturation_mutlist,,,,,,,,0.56218,0.23257579863071443,,1.441617683587524,,1.001898841793762,,Neutral,Neutral,,Neutral,0.4040764037776835,,0.04098830623504775,-3.95075,,1.0044499841767236,,-1.4731500079116384,,Uncertain,,Neutral,,0.1627675069982617,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.4054,0.1023,-22.2419,-6.55462687626449,0.4978131721281743,Uncertain,0.997,pathogenic,-4.212,available,https://doi.org/10.1101/2022.10.22.513328 +R175V,NP_000537:p.Arg175Val,,,,,saturation_mutlist,,,,,,,,-0.11099,-0.27996445059776304,,0.3968975713122755,,0.14295378565613776,,Neutral,Neutral,,Neutral,0.7908171042856915,,0.1629002585623551,-3.61917,,0.24962885714048125,,-1.6847705714297594,,Uncertain,,Neutral,,0.04229924788304358,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,damaging,,-0.417,0.1023,-22.2419,-7.34706045896784,0.6659790426552431,Uncertain,0.9898,pathogenic,-4.288,available,https://doi.org/10.1101/2022.10.22.513328 +R175W,NP_000537:p.Arg175Trp,,,,,saturation_mutlist,,,,,,,,4.82713,-0.005346788763999942,,0.6098503773413756,,2.718490188670688,,Uncertain,Neutral,,Uncertain,0.2768588858505935,,0.2521467032104718,13.14074,,0.2301752212428598,,6.685457610621429,,Uncertain,,Destabilizing,,0.6805610769796956,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,neutral,,-0.4182,0.1023,-22.2419,-6.99788038686524,0.7456304957975548,Pathogenic,0.9938,pathogenic,-4.319,available,https://doi.org/10.1101/2022.10.22.513328 +R175Y,NP_000537:p.Arg175Tyr,,,,,saturation_mutlist,,,,,,,,5.0811,0.12271281987428663,,0.8987372212699944,,2.989918610634997,,Uncertain,Neutral,,Uncertain,0.277340437161046,,0.25271611111333764,13.57188,,0.5029770328183985,,7.037428516409199,,Uncertain,,Destabilizing,,0.6543830327565815,7.859,3.126,5.835,8.493,,True,7.859,,neutral,neutral,neutral,,True,5.835,,neutral,neutral,neutral,neutral,,-0.4219,0.1023,-22.2419,-6.99788038686524,0.7297744245899348,Pathogenic,0.9977,pathogenic,-4.49,available,https://doi.org/10.1101/2022.10.22.513328 +C176A,NP_000537:p.Cys176Ala,,,,,saturation_mutlist,,,,,,,,-0.155,0.3946684217453003,,-0.136953649719944,,-0.145976824859972,,Neutral,Neutral,,Neutral,0.1131037335177607,,0.2152518425148938,2.44891,,0.05974230329051061,,1.2543261516452553,,Uncertain,,Neutral,,0.4947546438206372,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.4887,0.042,-22.2419,-4.93975593132497,0.8475624041160869,Pathogenic,0.9997,pathogenic,-4.581,available,https://doi.org/10.1101/2022.10.22.513328 +C176D,NP_000537:p.Cys176Asp,,,,,saturation_mutlist,,,,,,,,-0.25681,-0.02007525205612182,,-0.3358080356444302,,-0.2963090178222151,,Neutral,Neutral,,Neutral,0.2759143691763836,,0.19436895771602317,2.53063,,0.4662084062137093,,1.4984192031068546,,Uncertain,,Neutral,,0.9458665728549214,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,uncertain,,-0.5959,0.042,-22.2419,-8.23221353167741,0.8675522644058249,Pathogenic,0.9998,pathogenic,-4.8,available,https://doi.org/10.1101/2022.10.22.513328 +C176E,NP_000537:p.Cys176Glu,,,,,saturation_mutlist,,,,,,,,-0.69944,0.27651955366134645,,-0.49325646972802023,,-0.5963482348640101,,Neutral,Neutral,,Neutral,0.35996682959518334,,0.11086431578626052,3.65295,,0.8840243615649076,,2.268487180782454,,Uncertain,,Uncertain,,1.3705104431288817,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.5835,0.042,-22.2419,-8.23221353167741,0.8689997824316511,Pathogenic,1.0,pathogenic,-4.832,available,https://doi.org/10.1101/2022.10.22.513328 +C176F,NP_000537:p.Cys176Phe,"hg19,17:g.7578402_7578403delinsAA, hg19,17:g.7578403C>A, hg19,17:g.7675085C>A, hg38,17:g.7675084_7675085delinsAA, hg38,17:g.7675085C>A",,3.9795609748e-06,0.951,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376569,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,1.88552,0.4156827199459076,-1.2269833333333333,-0.6710653650113269,0.3292683333333334,0.6072273174943366,Neutral,Neutral,Neutral,Neutral,Neutral,0.11824473543473626,0.9687986395646012,0.27406123375121727,21.91096,3.4954666666666667,0.5731268345696153,12.703213333333332,11.242043417284806,Destabilizing,Uncertain,Destabilizing,Destabilizing,3.0800950041227986,1.742487383892717,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.4826,0.042,-22.2419,-7.79483400731286,0.8702760474222173,Pathogenic,0.999,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176G,NP_000537:p.Cys176Gly,"hg19,17:g.7578404A>C, hg19,17:g.7675086A>C, hg38,17:g.7675086A>C",,,0.946,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376571,Conflicting classifications of pathogenicity,1,,,,,0.53382,1.0303720021247864,0.3397966666666667,0.8344426141390117,0.43680833333333335,0.6841313070695059,Neutral,Neutral,Uncertain,Neutral,Neutral,0.2164657662420886,0.5335404637159418,0.35444163276788937,1.06955,0.8295933333333334,1.0085418098215275,0.9495716666666667,1.0390459049107639,Neutral,Neutral,Neutral,Neutral,1.0294551908763305,0.4766492578700613,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.4811,0.042,-22.2419,-8.23221353167741,0.8578531622345413,Pathogenic,0.999,pathogenic,-4.632,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176H,NP_000537:p.Cys176His,,,,,saturation_mutlist,,,,,,,,3.1681,0.04311163902282713,,-0.5999448547488093,,1.2840775726255953,,Uncertain,Neutral,,Neutral,0.19458060526348384,,0.21400018152831057,19.61855,,0.5994190133739262,,10.108984506686962,,Uncertain,,Destabilizing,,1.463803138767725,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.5266,0.042,-8.9541,-7.32313789200967,0.1293479251583714,Benign,0.9995,pathogenic,-4.272,available,https://doi.org/10.1101/2022.10.22.513328 +C176I,NP_000537:p.Cys176Ile,,,,,saturation_mutlist,,,,,,,,-0.1105,0.5005458331108094,,-0.5545224361945919,,-0.33251121809729595,,Neutral,Neutral,,Neutral,0.20009537213574258,,0.23685576019789997,10.66997,,0.6707444196905921,,5.670357209845296,,Uncertain,,Destabilizing,,1.6231073081369853,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.5125,0.042,-22.2419,-8.23221353167741,0.869842654789464,Pathogenic,0.9998,pathogenic,-4.722,available,https://doi.org/10.1101/2022.10.22.513328 +C176K,NP_000537:p.Cys176Lys,,,,,saturation_mutlist,,,,,,,,0.04538,0.68351149559021,,0.009694353690506438,,0.027537176845253218,,Neutral,Neutral,,Neutral,0.24150864543915995,,0.21893009573619834,12.33999,,2.035007192404595,,7.187498596202298,,Uncertain,,Destabilizing,,1.8064772220632692,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.5841,0.042,-22.2419,-8.23221353167741,0.8670218090629438,Pathogenic,1.0,pathogenic,-4.792,available,https://doi.org/10.1101/2022.10.22.513328 +C176L,NP_000537:p.Cys176Leu,"hg19,17:g.7578402_7578403delinsTA, hg19,17:g.7578403_7578404delinsAG",,,,"cBioPortal,saturation_mutlist",,,,,,,,-0.67369,0.4573924803733826,-0.7952400000000001,-0.7842926881746238,-0.734465,-0.7289913440873119,Neutral,Neutral,Neutral,Neutral,Neutral,0.15528268760927022,0.17144615656234466,0.20985934099667722,11.62804,0.55306,0.38018514628436745,6.09055,6.004112573142184,Uncertain,Uncertain,Destabilizing,Destabilizing,0.5988332205770374,1.2965778695283736,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.5456,0.042,-22.2419,-8.23221353167741,0.8677963051580875,Pathogenic,0.9993,pathogenic,-4.602,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176M,NP_000537:p.Cys176Met,,,,,saturation_mutlist,,,,,,,,-0.97233,0.6098867702484131,,-0.5341594226332155,,-0.7532447113166078,,Neutral,Neutral,,Neutral,0.16477151491946374,,0.32036971711085893,9.01274,,0.4377012013807147,,4.725220600690358,,Uncertain,,Destabilizing,,1.2158983766438116,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.5128,0.042,-22.2419,-8.23221353167741,0.870007911639635,Pathogenic,0.9998,pathogenic,-4.711,available,https://doi.org/10.1101/2022.10.22.513328 +C176N,NP_000537:p.Cys176Asn,,,,,saturation_mutlist,,,,,,,,0.73786,0.09540755987167358,,-0.18968864567966884,,0.2740856771601656,,Neutral,Neutral,,Neutral,0.16462679519033815,,0.24599562553505672,8.37829,,0.34526260434458217,,4.361776302172291,,Uncertain,,Destabilizing,,0.7444949499482698,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.5383,0.042,-22.2419,-8.23221353167741,0.8705661557306118,Pathogenic,0.9999,pathogenic,-4.68,available,https://doi.org/10.1101/2022.10.22.513328 +C176P,NP_000537:p.Cys176Pro,,,,,saturation_mutlist,,,,,,,,-1.96937,-0.14255768299102783,,1.9176309890952654,,-0.025869505452367325,,Neutral,Neutral,,Neutral,0.3617050992692705,,0.7287647126660152,4.07535,,2.8937653023218743,,3.4845576511609373,,Uncertain,,Destabilizing,,1.2925637049065681,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,uncertain,,-0.607,0.042,-22.2419,-8.23221353167741,0.8705425558578439,Pathogenic,0.9997,pathogenic,-4.76,available,https://doi.org/10.1101/2022.10.22.513328 +C176Q,NP_000537:p.Cys176Gln,,,,,saturation_mutlist,,,,,,,,0.25804,0.4887996220588684,,-0.25963784905100246,,-0.0007989245255012323,,Neutral,Neutral,,Neutral,0.2332313254333466,,0.21514045017954422,10.01373,,0.900609518257728,,5.457169759128864,,Uncertain,,Destabilizing,,1.3242294645040558,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.5623,0.042,-22.2419,-8.23221353167741,0.8694632753052041,Pathogenic,1.0,pathogenic,-4.73,available,https://doi.org/10.1101/2022.10.22.513328 +C176R,NP_000537:p.Cys176Arg,"hg19,17:g.7578402_7578404delinsCCG, hg19,17:g.7578404A>G, hg19,17:g.7675086A>G, hg38,17:g.7675084_7675086delinsCCG, hg38,17:g.7675086A>G",,,0.940,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","634759, 376573","Likely pathogenic, Conflicting classifications of pathogenicity","0, 1",,,,,0.59956,0.7392142093181611,-1.7676866666666669,-0.1660285097496346,-0.5840633333333334,0.2167657451251827,Neutral,Neutral,Neutral,Neutral,Neutral,0.2698962497669853,1.985818876372051,0.2683277685853706,13.67204,1.8800433333333333,1.3114839078291027,7.776041666666667,7.491761953914552,Uncertain,Uncertain,Destabilizing,Destabilizing,0.8124297566080542,1.6709875509401961,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.5409,0.042,-22.2419,-8.23221353167741,0.7787886911920763,Pathogenic,0.9999,pathogenic,-4.472,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176S,NP_000537:p.Cys176Ser,"hg19,17:g.7578402_7578403delinsAG, hg19,17:g.7578403C>G, hg19,17:g.7578404A>T, hg19,17:g.7675085C>G, hg19,17:g.7675086A>T, hg38,17:g.7675085C>G, hg38,17:g.7675086A>T, hg38,17:g.7675086_7675087delinsTA",,,"0.945, 0.946","cBioPortal,COSMIC,ClinVar,saturation_mutlist",376570,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,Tier I - Strong,1,0.68921,0.38874210596084596,-0.19308666666666666,0.08444221329648617,0.24806166666666668,0.3868261066482431,Neutral,Neutral,Neutral,Neutral,Neutral,0.09835398600776721,0.2679433293731261,0.2204053122525917,1.72955,-0.53798,0.30044702907062004,0.595785,1.01499851453531,Neutral,Neutral,Neutral,Neutral,0.29997460303610146,0.6796782070519174,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.4116,0.042,-8.9541,-4.93975593132497,0.8708488859765695,Pathogenic,0.9997,pathogenic,-4.462,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176T,NP_000537:p.Cys176Thr,,,,,saturation_mutlist,,,,,,,,0.72787,0.896516854763031,,-0.04173649882737344,,0.3430667505863133,,Neutral,Neutral,,Neutral,0.20722683064441247,,0.2764605432704291,4.51273,,0.4834357853092084,,2.4980828926546046,,Uncertain,,Uncertain,,0.9427075437433314,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.5141,0.042,-22.2419,-4.93975593132497,0.8708611291193729,Pathogenic,0.9999,pathogenic,-4.643,available,https://doi.org/10.1101/2022.10.22.513328 +C176V,NP_000537:p.Cys176Val,"hg19,17:g.7578403_7578404delinsAC",,,,"cBioPortal,saturation_mutlist",,,,,,,,-0.02749,0.605621509552002,-0.58753,-0.48296470220933735,-0.30751,-0.25522735110466865,Neutral,Neutral,Neutral,Neutral,Neutral,0.22165985401527416,0.15808143492095036,0.2069251363819983,8.32117,0.6701799999999999,0.32641761179349654,4.495675,4.323793805896749,Uncertain,Uncertain,Destabilizing,Destabilizing,1.6884445106073223,1.2087729120191086,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.5106,0.042,-22.2419,-8.23221353167741,0.8708143264476187,Pathogenic,0.9997,pathogenic,-4.627,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176W,NP_000537:p.Cys176Trp,"hg19,17:g.7578402G>C, hg19,17:g.7675084G>C, hg38,17:g.7675084G>C",,0.0,0.863,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376572,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,Tier I - Strong,1,2.82774,0.3470002853870392,-1.0402500000000001,-0.9689383363231595,0.8937449999999999,0.9294008318384201,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.1313620948437659,0.5807956319280188,0.2952316439063708,27.08701,2.4713133333333333,0.6362284493987199,14.779161666666667,13.861619224699359,Uncertain,Uncertain,Destabilizing,Destabilizing,2.1663686060061176,2.044285095668448,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.4858,0.042,-22.2419,-7.79483400731286,0.8629961834897071,Pathogenic,0.9993,pathogenic,-4.652,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176Y,NP_000537:p.Cys176Tyr,"hg19,17:g.7578403C>T, hg19,17:g.7675085C>T, hg38,17:g.7675085C>T",,,0.949,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",186451,Pathogenic,2,,,,,2.78901,0.13094130516052246,-0.4263066666666666,-0.46224982497927986,1.1813516666666668,1.1633800875103602,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.14523090482514056,0.5147928182828073,0.2829906744792488,23.84814,2.455896666666667,0.9336832118651888,13.152018333333334,12.390911605932594,Uncertain,Uncertain,Destabilizing,Destabilizing,1.8611824266011352,1.941742878464153,5.236,3.854,2.51,3.025,,False,5.236,,neutral,neutral,neutral,,False,2.51,,neutral,neutral,neutral,neutral,,-0.492,0.042,-22.2419,-7.79483400731286,0.8684118041381633,Pathogenic,0.9994,pathogenic,-4.51,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177A,NP_000537:p.Pro177Ala,"hg19,17:g.7578401G>C, hg38,17:g.7675083G>C",,,0.866,"ClinVar,saturation_mutlist",2585883,Uncertain significance,1,,,,,1.6932,0.39314125299453734,,-0.6022814202663064,,0.5454592898668469,,Neutral,Neutral,,Neutral,0.1946964811831383,,0.021064731909461964,1.64624,,-0.15654230420509394,,0.744848847897453,,Neutral,,Neutral,,0.17389692518878136,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,neutral,,-0.3223,0.0589,-22.2419,-5.74498225218225,0.5352815203588073,Uncertain,0.9442,pathogenic,-3.804,available,https://doi.org/10.1101/2022.10.22.513328 +P177C,NP_000537:p.Pro177Cys,,,,,saturation_mutlist,,,,,,,,2.37558,0.26848034620285033,,0.27513724064773215,,1.325358620323866,,Uncertain,Neutral,,Neutral,0.1871759870623089,,0.11209739509577495,2.01442,,0.5547274542780757,,1.2845737271390378,,Uncertain,,Neutral,,0.16367602985475363,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.355,0.0589,-22.2419,-6.36602491297949,0.8664227059498215,Pathogenic,0.9933,pathogenic,-4.311,available,https://doi.org/10.1101/2022.10.22.513328 +P177D,NP_000537:p.Pro177Asp,,,,,saturation_mutlist,,,,,,,,2.10821,0.6688288056850433,,-0.7275246271618458,,0.6903426864190771,,Uncertain,Neutral,,Neutral,0.1905051879619014,,0.10264152499561864,1.55678,,-0.25101089591766446,,0.6528845520411678,,Neutral,,Neutral,,0.1964761943194996,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.3809,0.0589,-22.2419,-7.48295067145383,0.8704042824955825,Pathogenic,0.9991,pathogenic,-4.324,available,https://doi.org/10.1101/2022.10.22.513328 +P177E,NP_000537:p.Pro177Glu,,,,,saturation_mutlist,,,,,,,,1.37511,0.3858095061779022,,-0.8401746898601449,,0.2674676550699276,,Neutral,Neutral,,Neutral,0.20028016758834258,,0.09770586188808952,1.38298,,-0.40991615813933047,,0.4865319209303348,,Neutral,,Neutral,,0.17840640487826495,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.3647,0.0589,-22.2419,-6.6080401806179,0.730669776976751,Pathogenic,0.9968,pathogenic,-4.207,available,https://doi.org/10.1101/2022.10.22.513328 +P177F,NP_000537:p.Pro177Phe,"hg19,17:g.7578400_7578401delinsAA, hg38,17:g.7675082_7675083delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.92238,0.4951261281967163,0.6312933333333333,-0.7833225854394673,1.2768366666666666,0.5695287072802664,Neutral,Neutral,Neutral,Neutral,Neutral,0.2622186223768108,0.20251908639818508,0.16807911649752122,1.75805,0.92619,-0.6327247354634727,1.34212,0.5626626322682635,Neutral,Neutral,Neutral,Neutral,0.3415119483512497,0.12322756607600507,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.3834,0.0589,-22.2419,-5.67897689218301,0.747731497163068,Pathogenic,0.9953,pathogenic,-4.288,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177G,NP_000537:p.Pro177Gly,,,,,saturation_mutlist,,,,,,,,2.15743,0.9547076392173767,,0.2090467492024587,,1.1832383746012294,,Uncertain,Neutral,,Neutral,0.19239849259549896,,0.061890351977527416,1.98543,,0.5212319125867291,,1.2533309562933646,,Neutral,,Neutral,,0.09925523310427828,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,neutral,,-0.3366,0.0589,-22.2419,-8.0218864672828,0.8523687485385587,Pathogenic,0.993,pathogenic,-4.38,available,https://doi.org/10.1101/2022.10.22.513328 +P177H,NP_000537:p.Pro177His,"hg19,17:g.7578400G>T, hg19,17:g.7675082G>T, hg38,17:g.7675081_7675082delinsAT, hg38,17:g.7675082G>T",,,0.844,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",956854,Uncertain significance,2,,,,,2.63639,0.4097080087661743,0.7778899999999999,-1.0326762424967153,1.7071399999999999,0.8018568787516424,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.2217780631821731,0.15382823082906463,0.024106390250070976,2.29553,1.2207466666666666,-0.6256978676553038,1.7581383333333331,0.834916066172348,Uncertain,Uncertain,Neutral,Neutral,0.5378765085242356,0.13560944798390528,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.361,0.0589,-22.2419,-5.18672710714455,0.5803738565829757,Uncertain,0.9769,pathogenic,-3.985,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177I,NP_000537:p.Pro177Ile,"hg38,17:g.7675082_7675083delinsAT",,,,"COSMIC,saturation_mutlist",,,,,,,,1.80975,0.44498188734054567,0.7221100000000001,-0.6423937920569731,1.26593,0.5836781039715134,Neutral,Neutral,Neutral,Neutral,Neutral,0.21283698154976832,0.32369362582540917,0.1420076768815648,1.88765,1.1062366666666665,-0.515222916576385,1.4969433333333333,0.6862135417118076,Neutral,Neutral,Neutral,Neutral,0.486130021313457,0.13008352148597305,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.3664,0.0589,-22.2419,-5.53892850552698,0.7858770196504259,Pathogenic,0.9819,pathogenic,-4.188,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177K,NP_000537:p.Pro177Lys,,,,,saturation_mutlist,,,,,,,,1.78212,0.5679191422462463,,-0.5463766871869847,,0.6178716564065077,,Neutral,Neutral,,Neutral,0.20309352050916804,,0.07751485107108382,1.77404,,-0.38873684430564986,,0.6926515778471751,,Neutral,,Neutral,,0.12304491699630844,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.3563,0.0589,-22.2419,-6.92303379444111,0.869440850396133,Pathogenic,0.9954,pathogenic,-4.377,available,https://doi.org/10.1101/2022.10.22.513328 +P177L,NP_000537:p.Pro177Leu,"hg19,17:g.7578399_7578400delinsAA, hg19,17:g.7578400G>A, hg19,17:g.7675082G>A, hg38,17:g.7675081_7675082delinsAA, hg38,17:g.7675082G>A",,3.9793076005e-06,0.865,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406583,Conflicting classifications of pathogenicity,1,Uncertain significance,1,,,1.52429,0.40891422510147096,0.6464866666666667,-1.0543435582171654,1.0853883333333334,0.23497322089141726,Neutral,Neutral,Neutral,Neutral,Neutral,0.2080231487994394,0.07903114421261756,0.1653229124585606,1.48204,0.6636066666666667,-0.8045203228527443,1.0728233333333335,0.33875983857362785,Neutral,Neutral,Neutral,Neutral,0.3316402871921457,0.13265511487188286,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.371,0.0589,-22.2419,-5.21377652326031,0.1751516844548883,Benign,0.9256,pathogenic,-3.776,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177M,NP_000537:p.Pro177Met,,,,,saturation_mutlist,,,,,,,,1.55499,0.5001780533790589,,-0.7247335706033803,,0.4151282146983099,,Neutral,Neutral,,Neutral,0.2049797221209104,,0.06365660589346533,1.51811,,-0.46921113470372083,,0.5244494326481396,,Neutral,,Neutral,,0.18254259016647054,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.322,0.0589,-22.2419,-5.8221259721004,0.7745890402522604,Pathogenic,0.9905,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328 +P177N,NP_000537:p.Pro177Asn,,,,,saturation_mutlist,,,,,,,,2.39485,0.5992067730426789,,-0.6352700499739631,,0.8797899750130185,,Uncertain,Neutral,,Neutral,0.19154826477855955,,0.08193465934799726,1.98108,,-0.23712361080427416,,0.8719781945978629,,Neutral,,Neutral,,0.2312838092755333,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.349,0.0589,-22.2419,-7.48295067145383,0.8703397884371771,Pathogenic,0.9975,pathogenic,-4.311,available,https://doi.org/10.1101/2022.10.22.513328 +P177Q,NP_000537:p.Pro177Gln,,,,,saturation_mutlist,,,,,,,,1.63967,0.5062478017807007,,-0.589122664654648,,0.5252736676726759,,Neutral,Neutral,,Neutral,0.18670965367746079,,0.04017241720446792,1.84498,,-0.18686646714269353,,0.8290567664286532,,Neutral,,Neutral,,0.15672265865503948,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.3507,0.0589,-22.2419,-7.48295067145383,0.8625492575619975,Pathogenic,0.9875,pathogenic,-4.069,available,https://doi.org/10.1101/2022.10.22.513328 +P177R,NP_000537:p.Pro177Arg,"hg19,17:g.7578400G>C, hg19,17:g.7675082G>C, hg38,17:g.7675082G>C",,0.0,0.893,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458547,Pathogenic/Likely pathogenic,2,,,,,2.03933,0.6275108885765076,1.1730133333333332,-0.7347393186320228,1.6061716666666666,0.6522953406839886,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.22712446060570604,0.14081743957652718,0.13477403551808295,2.00102,1.2058966666666666,-0.5287996454157246,1.6034583333333332,0.7361101772921377,Uncertain,Uncertain,Neutral,Neutral,0.327357926061911,0.10332808285584183,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.3243,0.0589,-8.9541,-6.44304391163323,0.817385674750621,Pathogenic,0.9661,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177S,NP_000537:p.Pro177Ser,"hg19,17:g.7578401G>A, hg19,17:g.7675083G>A, hg38,17:g.7675083G>A",,,0.877,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",646495,Uncertain significance,2,,,,,2.31456,0.5493718683719635,0.9954666666666666,-0.5339969280458741,1.6550133333333334,0.890281535977063,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.18787517544585008,0.29391556625821796,0.10701922122860077,1.82582,1.2571433333333333,-0.11829180219559608,1.5414816666666666,0.853764098902202,Neutral,Neutral,Neutral,Neutral,0.5639732349638196,0.1924410395014095,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,neutral,,-0.2491,0.0589,-7.9541,-5.86050146488935,0.7119701149400479,Pathogenic,0.9845,pathogenic,-3.885,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177T,NP_000537:p.Pro177Thr,"hg19,17:g.7578401G>T, hg19,17:g.7675083G>T, hg38,17:g.7675083G>T",,,0.878,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",482220,Uncertain significance,2,,,,,2.38959,0.7266888296604157,1.3133766666666666,-0.4616931623766285,1.8514833333333334,0.9639484188116858,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.18595852530876586,0.1862581794773647,0.03968450467747966,2.1887,1.0481833333333335,-0.23327461750022016,1.6184416666666666,0.9777126912498899,Uncertain,Uncertain,Neutral,Neutral,0.6501037057953821,0.16484179102861507,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.3341,0.0589,-22.2419,-6.28883422013193,0.7732105001708429,Pathogenic,0.978,pathogenic,-4.044,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177V,NP_000537:p.Pro177Val,"hg38,17:g.7675081_7675083delinsCAC",,,,"COSMIC,saturation_mutlist",,,,,,,,2.03861,0.5535071086883545,,-0.4936623398075737,,0.7724738300962131,,Uncertain,Neutral,,Neutral,0.21230938006936845,,0.14496799792344825,2.07041,,-0.3520745264110951,,0.8591677367944524,,Uncertain,,Neutral,,0.10198758193965703,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.3218,0.0589,-22.2419,-5.46003183608147,0.4374821948059262,Uncertain,0.9678,pathogenic,-4.082,available,https://doi.org/10.1101/2022.10.22.513328 +P177W,NP_000537:p.Pro177Trp,,,,,saturation_mutlist,,,,,,,,2.09721,0.17785549640655518,,-1.3377135927483164,,0.37974820362584183,,Uncertain,Neutral,,Neutral,0.2940634100560856,,0.22143649853054567,2.09606,,-1.0308117114909874,,0.5326241442545063,,Uncertain,,Neutral,,0.17710452401450774,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.3959,0.0589,-22.2419,-6.55968231030577,0.8707412256392333,Pathogenic,0.9959,pathogenic,-4.659,available,https://doi.org/10.1101/2022.10.22.513328 +P177Y,NP_000537:p.Pro177Tyr,,,,,saturation_mutlist,,,,,,,,2.08247,0.20990561246871947,,-0.7618328180408591,,0.6603185909795704,,Uncertain,Neutral,,Neutral,0.27926152358777473,,0.17589735939783296,1.81117,,-0.647246566860832,,0.581961716569584,,Neutral,,Neutral,,0.16560698232262674,46.264,12.434,51.485,7.38,,False,46.264,,neutral,neutral,neutral,,False,51.485,,neutral,neutral,neutral,uncertain,,-0.3844,0.0589,-22.2419,-6.3926303538684,0.8135704555410429,Pathogenic,0.9945,pathogenic,-4.298,available,https://doi.org/10.1101/2022.10.22.513328 +H178A,NP_000537:p.His178Ala,,,,,saturation_mutlist,,,,,,,,-0.15101,0.33863881587982175,,0.415734864412091,,0.1323624322060455,,Neutral,Neutral,,Neutral,0.1368085432623043,,0.06375868546446826,-0.07663,,0.39147310559161186,,0.15742155279580594,,Neutral,,Neutral,,0.08568085288461184,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2016,1.0379,-22.2419,-4.95611026951591,0.6555096965378207,Uncertain,0.9942,pathogenic,-3.977,available,https://doi.org/10.1101/2022.10.22.513328 +H178C,NP_000537:p.His178Cys,,,,,saturation_mutlist,,,,,,,,-0.06557,0.31360635042190554,,1.1507434602390403,,0.5425867301195202,,Neutral,Neutral,,Neutral,0.14143995685201546,,0.015298643582134126,0.0014,,1.0589828812432562,,0.5301914406216282,,Neutral,,Neutral,,0.19756642999633645,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2561,1.0379,-22.2419,-5.6845487765731,0.8324060212218808,Pathogenic,0.942,pathogenic,-4.133,available,https://doi.org/10.1101/2022.10.22.513328 +H178D,NP_000537:p.His178Asp,"hg19,17:g.7578398G>C, hg19,17:g.7675080G>C, hg38,17:g.7675080G>C",,,0.892,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",482223,Pathogenic,3,,,,,-0.44979,0.800893075466156,-0.3445566666666667,0.0159798134426094,-0.3971733333333334,-0.2169050932786953,Neutral,Neutral,Neutral,Neutral,Neutral,0.20583484008892988,0.28169110533032854,0.07996339522454468,-0.40593,-0.2964833333333334,0.1952192615563667,-0.35120666666666667,-0.10535536922181665,Neutral,Neutral,Neutral,Neutral,0.477884157883012,0.10902824316831483,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2488,1.0379,-22.2419,-4.01982276158121,0.8674708756181666,Pathogenic,0.9988,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H178E,NP_000537:p.His178Glu,,,,,saturation_mutlist,,,,,,,,-0.82626,0.448408842086792,,-0.12489064066719413,,-0.47557532033359706,,Neutral,Neutral,,Neutral,0.09307906743569755,,0.0489758953163536,-0.37301,,0.08680235304914201,,-0.143103823475429,,Neutral,,Neutral,,0.1383386935586286,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2603,1.0379,-22.2419,-4.01982276158121,0.8707319850721207,Pathogenic,0.9991,pathogenic,-4.245,available,https://doi.org/10.1101/2022.10.22.513328 +H178F,NP_000537:p.His178Phe,,,,,saturation_mutlist,,,,,,,,-0.75849,0.45998928546905515,,-0.2317469930085421,,-0.49511849650427103,,Neutral,Neutral,,Neutral,0.11009565576032763,,0.08589354449230731,-0.54778,,-0.002388895929009871,,-0.27508444796450493,,Neutral,,Neutral,,0.14517749838010247,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2232,1.0379,-22.2419,-4.31420048674115,0.8314027261379388,Pathogenic,0.9358,pathogenic,-4.037,available,https://doi.org/10.1101/2022.10.22.513328 +H178G,NP_000537:p.His178Gly,,,,,saturation_mutlist,,,,,,,,0.24078,0.918368057012558,,1.0651700597540756,,0.6529750298770378,,Neutral,Neutral,,Neutral,0.17549697466767417,,0.05985983290675195,-1.59414,,0.9154019850735228,,-0.33936900746323856,,Neutral,,Neutral,,0.3112842840680107,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2841,1.0379,-22.2419,-5.86878639637885,0.8024246580066932,Pathogenic,0.9965,pathogenic,-4.02,available,https://doi.org/10.1101/2022.10.22.513328 +H178I,NP_000537:p.His178Ile,,,,,saturation_mutlist,,,,,,,,-0.46084,0.5443597340583801,,0.1340089690185514,,-0.1634155154907243,,Neutral,Neutral,,Neutral,0.1424895165853653,,0.0707140799655878,0.5945,,0.1592537538999944,,0.3768768769499972,,Neutral,,Neutral,,0.16793066461823775,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2878,1.0379,-22.2419,-4.80953211986514,0.4572442716686671,Uncertain,0.9893,pathogenic,-3.926,available,https://doi.org/10.1101/2022.10.22.513328 +H178K,NP_000537:p.His178Lys,,,,,saturation_mutlist,,,,,,,,-0.57603,0.5156052660942078,,0.17922034737501755,,-0.19840482631249123,,Neutral,Neutral,,Neutral,0.15472006898848803,,0.05147773782895713,-0.3332,,0.21114581087799733,,-0.06102709456100133,,Neutral,,Neutral,,0.1404448088577957,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2445,1.0379,-22.2419,-6.54826484089745,0.8701766080400031,Pathogenic,0.9974,pathogenic,-4.09,available,https://doi.org/10.1101/2022.10.22.513328 +H178L,NP_000537:p.His178Leu,"hg19,17:g.7578397T>A, hg38,17:g.7675079T>A",,,0.843,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.74682,0.5965651059150696,-0.34240333333333334,-0.13163208580143573,-0.5446116666666667,-0.4392260429007179,Neutral,Neutral,Neutral,Neutral,Neutral,0.17267740148713373,0.29393345146289307,0.10138934266233389,-0.42858,0.5115633333333333,-0.2095481199109528,0.04149166666666662,-0.3190640599554764,Neutral,Neutral,Neutral,Neutral,0.20332406323130786,0.11753986642062025,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2514,1.0379,-22.2419,-4.78633146478376,0.2352829985126827,Benign,0.9223,pathogenic,-3.776,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H178M,NP_000537:p.His178Met,,,,,saturation_mutlist,,,,,,,,-0.86549,0.5982705307006836,,0.14756947788773392,,-0.35896026105613305,,Neutral,Neutral,,Neutral,0.12170183041630928,,0.06268658568978497,-0.50497,,0.11935727537590886,,-0.1928063623120456,,Neutral,,Neutral,,0.16929042659425222,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2015,1.0379,-22.2419,-5.61236611934688,0.8369289085395977,Pathogenic,0.99,pathogenic,-4.123,available,https://doi.org/10.1101/2022.10.22.513328 +H178N,NP_000537:p.His178Asn,"hg19,17:g.7578398G>T, hg38,17:g.7675080G>T",,,0.722,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",421546,Uncertain significance,2,,,,,0.03063,0.47551565408706664,-0.32177000000000006,0.27909974301499346,-0.14557000000000003,0.15486487150749673,Neutral,Neutral,Neutral,Neutral,Neutral,0.12946678794967548,0.1806014536670917,0.03838429201204933,-0.16064,-0.021656666666666668,0.2693071999880344,-0.09114833333333333,0.054333599994017184,Neutral,Neutral,Neutral,Neutral,0.22933576873706862,0.19764619555341553,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.0989,1.0379,-0.8147,-2.16847537029545,0.0274639830779874,Benign,0.9457,pathogenic,-3.29,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H178P,NP_000537:p.His178Pro,"hg19,17:g.7578397T>G, hg38,17:g.7675079T>G",,,0.918,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",485030,Conflicting classifications of pathogenicity,1,,,,,-1.08638,0.3241828393936157,3.357143333333333,1.2105919677728831,1.1353816666666665,0.06210598388644162,Uncertain,Neutral,Neutral,Neutral,Neutral,0.1913551302257077,0.26309742635676897,0.12732106331333465,2.44692,13.852946666666666,3.2717101175502914,8.149933333333333,2.8593150587751457,Uncertain,Uncertain,Destabilizing,Uncertain,7.035231555773807,1.444633195785344,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.3648,1.0379,-22.2419,-6.94912649278667,0.8226450287003313,Pathogenic,0.9813,pathogenic,-4.325,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H178Q,NP_000537:p.His178Gln,"hg19,17:g.7578396G>C, hg19,17:g.7578396G>T, hg19,17:g.7675078G>T, hg38,17:g.7675078G>C, hg38,17:g.7675078G>T",,,0.814,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","947223, 575702","Pathogenic/Likely pathogenic, Pathogenic/Likely pathogenic","2, 2",,,,,-0.41607,0.42243984699249265,-2.0222200000000004,0.32799004753388966,-1.2191450000000001,-0.04403997623305517,Uncertain,Neutral,Neutral,Neutral,Neutral,0.08756411641232989,2.7871862367030067,0.05646980009066076,-0.32503,0.1788,0.3626940705739982,-0.073115,0.018832035286999116,Neutral,Neutral,Neutral,Neutral,0.1812436450380169,0.12435619697140905,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.1698,1.0379,-22.2419,-3.64554007785688,0.4295374303540418,Uncertain,0.9953,pathogenic,-3.823,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H178R,NP_000537:p.His178Arg,"hg19,17:g.7578397T>C, hg38,17:g.7675079T>C",,,0.882,"cBioPortal,ClinVar,saturation_mutlist",2780373,Uncertain significance,2,,,,,-0.2224,0.5393702793121338,,0.11907330935252441,,-0.051663345323737786,,Neutral,Neutral,,Neutral,0.13992017134730084,,0.04785518302951332,-0.10402,,0.06626457430262334,,-0.018877712848688333,,Neutral,,Neutral,,0.16200805471568291,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2379,1.0379,-22.2419,-5.86482744817569,0.8174109132435935,Pathogenic,0.9907,pathogenic,-4.101,available,https://doi.org/10.1101/2022.10.22.513328 +H178S,NP_000537:p.His178Ser,,,,,saturation_mutlist,,,,,,,,0.03156,0.4670140862464905,,0.40286460936619917,,0.21721230468309957,,Neutral,Neutral,,Neutral,0.1542734617083483,,0.039377812100986745,0.02053,,0.4823752759232664,,0.2514526379616332,,Neutral,,Neutral,,0.10893449593635611,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2075,1.0379,-22.2419,-5.02560375433689,0.4869245274539865,Uncertain,0.9867,pathogenic,-3.78,available,https://doi.org/10.1101/2022.10.22.513328 +H178T,NP_000537:p.His178Thr,,,,,saturation_mutlist,,,,,,,,0.24735,0.7517575192451477,,0.33917774966172964,,0.2932638748308648,,Neutral,Neutral,,Neutral,0.16979651855327269,,0.06321148528744015,0.21636,,0.47989809909670206,,0.348129049548351,,Neutral,,Neutral,,0.177106854806759,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.1846,1.0379,-8.9541,-3.73985535730397,0.1076288212504749,Benign,0.9929,pathogenic,-3.708,available,https://doi.org/10.1101/2022.10.22.513328 +H178V,NP_000537:p.His178Val,,,,,saturation_mutlist,,,,,,,,-0.24848,0.6180525541305542,,0.2760359274514275,,0.013777963725713757,,Neutral,Neutral,,Neutral,0.17287310111848725,,0.05455696180864867,0.6177,,0.2709769076335346,,0.4443384538167673,,Neutral,,Neutral,,0.1260046802343466,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2442,1.0379,-22.2419,-4.95214696049574,0.5670510901653264,Uncertain,0.9864,pathogenic,-3.969,available,https://doi.org/10.1101/2022.10.22.513328 +H178W,NP_000537:p.His178Trp,,,,,saturation_mutlist,,,,,,,,-0.82499,0.34483429193496706,,-0.6466651160998397,,-0.7358275580499198,,Neutral,Neutral,,Neutral,0.13253226364922086,,0.08592994206653047,-0.44926,,-0.32150082849286604,,-0.385380414246433,,Neutral,,Neutral,,0.1981985269725044,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.2395,1.0379,-22.2419,-4.5273237823316,0.868863205936934,Pathogenic,0.9512,pathogenic,-4.427,available,https://doi.org/10.1101/2022.10.22.513328 +H178Y,NP_000537:p.His178Tyr,"hg38,17:g.7675080G>A, hg38,17:g.7675080_7675081delinsAA",,,0.870,"COSMIC,saturation_mutlist",,,,,,,,-0.68554,0.09513010740280149,-0.030383333333333335,-0.16306762590895654,-0.3579616666666667,-0.4243038129544783,Neutral,Neutral,Neutral,Neutral,Neutral,0.052655581066094456,0.138703060849027,0.08627433500916176,-0.45147,0.12108666666666666,0.07361516956988017,-0.16519166666666665,-0.1889274152150599,Neutral,Neutral,Neutral,Neutral,0.2491108005598223,0.15724720961594635,68.68,10.31,79.065,9.693,,False,68.68,,neutral,neutral,neutral,,False,79.065,,neutral,neutral,neutral,uncertain,,-0.1005,1.0379,-7.9541,-2.74682518781133,0.5859165950189872,Uncertain,0.9159,pathogenic,-3.802,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179A,NP_000537:p.His179Ala,,,,,saturation_mutlist,,,,,,,,-0.40257,0.6314687204360961,,0.6503742805744787,,0.12390214028723934,,Neutral,Neutral,,Neutral,0.2740585697172621,,0.046644988628504976,0.15083,,0.8608364584518937,,0.5058332292259469,,Neutral,,Neutral,,0.19315802027927695,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.2877,0.1023,-22.2419,-7.96459988094222,0.8199062659917653,Pathogenic,0.9996,pathogenic,-4.138,available,https://doi.org/10.1101/2022.10.22.513328 +H179C,NP_000537:p.His179Cys,,,,,saturation_mutlist,,,,,,,,-0.08192,0.5364290881156921,,1.1649210801223349,,0.5415005400611674,,Neutral,Neutral,,Neutral,0.2127841169137241,,0.07449728682343462,-6.49171,,1.2040458898346174,,-2.6438320550826915,,Uncertain,,Uncertain,,0.14144127557615377,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.3422,0.1023,-22.2419,-7.96459988094222,0.8608753046783912,Pathogenic,0.9878,pathogenic,-4.092,available,https://doi.org/10.1101/2022.10.22.513328 +H179D,NP_000537:p.His179Asp,"hg19,17:g.7578395G>C, hg19,17:g.7675077G>C, hg38,17:g.7675077G>C",,,0.916,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376610,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,-0.7104,1.4387731623649598,0.01519666666666667,0.4221723085941998,-0.3476016666666667,-0.14411384570290012,Neutral,Neutral,Uncertain,Neutral,Neutral,0.31144690965334415,0.1961342697122447,0.12768175753249167,-4.64798,-0.11394666666666668,1.1720901398221881,-2.3809633333333333,-1.7379449300889056,Uncertain,Uncertain,Uncertain,Neutral,1.7830438616652766,0.40270041443021537,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.3349,0.1023,-22.2419,-7.69757186110331,0.8073299519110599,Pathogenic,0.9985,pathogenic,-4.021,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179E,NP_000537:p.His179Glu,,,,,saturation_mutlist,,,,,,,,-0.88268,0.9812894248962403,,0.26148796305444894,,-0.3105960184727755,,Neutral,Neutral,,Neutral,0.27900267239801996,,0.09955224791258915,-3.8602,,0.9311928619380686,,-1.4645035690309656,,Uncertain,,Neutral,,0.330631721653901,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.3464,0.1023,-22.2419,-7.69757186110331,0.8646702189840025,Pathogenic,0.9992,pathogenic,-4.358,available,https://doi.org/10.1101/2022.10.22.513328 +H179F,NP_000537:p.His179Phe,,,,,saturation_mutlist,,,,,,,,-0.55442,0.6091020059585571,,-0.03656646427654339,,-0.2954932321382717,,Neutral,Neutral,,Neutral,0.18122748010809578,,0.11502462415884575,7.62803,,-0.6099503848538949,,3.5090398075730524,,Uncertain,,Destabilizing,,0.3507387828186315,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.3093,0.1023,-22.2419,-4.77994467744306,0.8625773414660352,Pathogenic,0.9988,pathogenic,-4.264,available,https://doi.org/10.1101/2022.10.22.513328 +H179G,NP_000537:p.His179Gly,,,,,saturation_mutlist,,,,,,,,0.04951,1.359295859336853,,1.3212046800488884,,0.6853573400244442,,Neutral,Uncertain,,Neutral,0.31342284179907326,,0.09372793441066875,-0.66497,,1.9135889663823733,,0.6243094831911866,,Neutral,,Neutral,,0.5371672047893624,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.3702,0.1023,-22.2419,-7.96459988094222,0.8656727466100131,Pathogenic,0.9994,pathogenic,-4.322,available,https://doi.org/10.1101/2022.10.22.513328 +H179I,NP_000537:p.His179Ile,,,,,saturation_mutlist,,,,,,,,0.31957,0.7128196310997009,,0.17874486502503137,,0.2491574325125157,,Neutral,Neutral,,Neutral,0.43530425343564516,,0.18649720429798716,5.14349,,0.10658866426704029,,2.62503933213352,,Uncertain,,Uncertain,,0.17802811730746795,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.3739,0.1023,-22.2419,-6.97647879047374,0.852473096295685,Pathogenic,0.9998,pathogenic,-4.443,available,https://doi.org/10.1101/2022.10.22.513328 +H179K,NP_000537:p.His179Lys,,,,,saturation_mutlist,,,,,,,,-0.38658,0.4853710293769836,,0.4477491692424806,,0.030584584621240307,,Neutral,Neutral,,Neutral,0.29456255884530175,,0.07169618725338017,3.11038,,1.1056757952422798,,2.10802789762114,,Uncertain,,Uncertain,,0.43033861696411096,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.3306,0.1023,-22.2419,-7.96459988094222,0.838518660770261,Pathogenic,0.9972,pathogenic,-4.389,available,https://doi.org/10.1101/2022.10.22.513328 +H179L,NP_000537:p.His179Leu,"hg19,17:g.7578394T>A, hg19,17:g.7675076T>A, hg38,17:g.7675076T>A",,,0.882,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376608,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,-0.91661,0.7448261618614197,-0.5496566666666667,-0.15751847027971277,-0.7331333333333334,-0.5370642351398565,Neutral,Neutral,Neutral,Neutral,Neutral,0.2415391070587833,0.39643574631402195,0.13302383962462888,2.23431,0.6309499999999999,-0.6088738909743854,1.4326299999999998,0.8127180545128072,Uncertain,Uncertain,Neutral,Neutral,1.1835527179076843,0.11397119511304867,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.2578,0.1023,-6.6322,-4.01906621514473,0.0017068321623512,Benign,0.996,pathogenic,-3.642,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179M,NP_000537:p.His179Met,,,,,saturation_mutlist,,,,,,,,-0.75945,0.6407993173599243,,0.1807428091461514,,-0.2893535954269243,,Neutral,Neutral,,Neutral,0.19777247539272436,,0.1339343532855924,1.495,,-0.13481035676561073,,0.6800948216171947,,Neutral,,Neutral,,0.11634951392379554,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.2876,0.1023,-22.2419,-6.97647879047374,0.8672856496971705,Pathogenic,0.9994,pathogenic,-4.303,available,https://doi.org/10.1101/2022.10.22.513328 +H179N,NP_000537:p.His179Asn,"hg19,17:g.7578395G>T, hg19,17:g.7675077G>T, hg38,17:g.7675077G>T",,3.9792442619e-06,0.902,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376609,Conflicting classifications of pathogenicity,1,,,,,0.02579,0.7028130793571472,0.23639666666666667,0.5335793217421008,0.13109333333333334,0.2796846608710504,Neutral,Neutral,Neutral,Neutral,Neutral,0.2230647395112755,0.0798042038714475,0.024709740412442033,1.01804,1.2501133333333334,0.771077291126808,1.1340766666666666,0.894558645563404,Neutral,Neutral,Neutral,Neutral,0.41562902692451864,0.2673503770102668,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.2944,0.1023,-22.2419,-7.69757186110331,0.5807464034444547,Uncertain,0.9987,pathogenic,-3.971,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179P,NP_000537:p.His179Pro,"hg19,17:g.7578394T>G, hg19,17:g.7675076T>G, hg38,17:g.7675076T>G",,,0.911,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376611,Conflicting classifications of pathogenicity,1,,,,,-0.2794,0.6625285625457764,5.311903333333333,3.5038171553382624,2.5162516666666668,1.6122085776691313,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.31239305812123735,0.41995815921218754,0.657050604016234,4.91827,7.835146666666667,4.898054477292309,6.376708333333333,4.908162238646154,Destabilizing,Destabilizing,Destabilizing,Destabilizing,1.0403486606048105,0.5376836184389888,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.4509,0.1023,-22.2419,-7.96459988094222,0.8061541515835262,Pathogenic,0.9947,pathogenic,-4.291,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179Q,NP_000537:p.His179Gln,"hg19,17:g.7578393A>C, hg19,17:g.7578393A>T, hg19,17:g.7675075A>C, hg19,17:g.7675075A>T, hg38,17:g.7675075A>C, hg38,17:g.7675075A>T",,0.0,0.790,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","406578, 376607","Pathogenic, Pathogenic/Likely pathogenic","3, 2",,,,,-0.36407,0.5219841289520264,-0.29456,0.46880023567434576,-0.329315,0.052365117837172875,Neutral,Neutral,Neutral,Neutral,Neutral,0.17191228766427094,0.6360516270450589,0.04745415542108265,1.99881,0.17516999999999994,0.6935205718282363,1.08699,1.3461652859141182,Neutral,Neutral,Neutral,Neutral,1.18052674618861,0.1943624647350548,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.1881,0.1023,-8.9541,-7.69757186110331,0.8620551083824842,Pathogenic,0.999,pathogenic,-4.083,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179R,NP_000537:p.His179Arg,"hg19,17:g.7578394T>C, hg19,17:g.7675076T>C, hg38,17:g.7675076T>C",,3.9786743057e-06,0.935,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376606,Conflicting classifications of pathogenicity,1,Oncogenic,1,Tier I - Strong,1,-0.05779,0.4707136106491089,0.3384366666666667,0.28938615589905364,0.14032333333333336,0.11579807794952682,Neutral,Neutral,Neutral,Neutral,Neutral,0.2882525963592707,0.2096260229286643,0.08027452356684249,4.05075,2.4633800000000003,0.5039287141420753,3.257065,2.2773393570710376,Uncertain,Uncertain,Destabilizing,Uncertain,0.942689804371866,0.36449079355854225,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.324,0.1023,-22.2419,-7.96459988094222,0.8467102023767425,Pathogenic,0.9963,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179S,NP_000537:p.His179Ser,"hg19,17:g.7578394_7578395delinsCT",,,,"cBioPortal,saturation_mutlist",,,,,,,,-0.17903,0.8407975769042969,,0.8107785357374069,,0.31587426786870343,,Neutral,Neutral,,Neutral,0.25860885701190356,,0.11354376425483462,-0.62363,,1.4209316233112126,,0.3986508116556063,,Neutral,,Neutral,,0.3658824107771697,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.2936,0.1023,-22.2419,-7.96459988094222,0.830593271067767,Pathogenic,0.9994,pathogenic,-4.132,available,https://doi.org/10.1101/2022.10.22.513328 +H179T,NP_000537:p.His179Thr,,,,,saturation_mutlist,,,,,,,,0.14713,1.2666627335548402,,0.5930594714427622,,0.3700947357213811,,Neutral,Uncertain,,Neutral,0.3302418583632326,,0.08798632585606476,2.01333,,1.0954299757070327,,1.5543799878535163,,Uncertain,,Neutral,,0.24855699755699168,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.3384,0.1023,-22.2419,-7.96459988094222,0.8562595611296209,Pathogenic,0.9997,pathogenic,-4.299,available,https://doi.org/10.1101/2022.10.22.513328 +H179V,NP_000537:p.His179Val,,,,,saturation_mutlist,,,,,,,,0.2182,0.9594799089431763,,0.36916130186089985,,0.2936806509304499,,Neutral,Neutral,,Neutral,0.39562495446137197,,0.16697196506688064,4.44151,,0.3407132546274094,,2.3911116273137045,,Uncertain,,Uncertain,,0.15005187961572852,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.3303,0.1023,-22.2419,-6.97647879047374,0.8369816923507047,Pathogenic,0.9997,pathogenic,-4.273,available,https://doi.org/10.1101/2022.10.22.513328 +H179W,NP_000537:p.His179Trp,,,,,saturation_mutlist,,,,,,,,-0.511,0.4832382583618164,,-0.3327204776744784,,-0.4218602388372392,,Neutral,Neutral,,Neutral,0.19013393604910342,,0.0333904822717823,6.91314,,-0.578077195673307,,3.1675314021633465,,Uncertain,,Destabilizing,,0.39683757136171005,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.3255,0.1023,-22.2419,-4.77994467744306,0.855720128041686,Pathogenic,0.9918,pathogenic,-4.376,available,https://doi.org/10.1101/2022.10.22.513328 +H179Y,NP_000537:p.His179Tyr,"hg19,17:g.7578395G>A, hg19,17:g.7578395_7578396delinsAA, hg19,17:g.7675077G>A, hg38,17:g.7675077G>A, hg38,17:g.7675077_7675078delinsAA",,,0.948,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127815,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,-0.51809,0.07545303344726562,-0.7524966666666667,0.08856462374862888,-0.6352933333333334,-0.21476268812568558,Neutral,Neutral,Neutral,Neutral,Neutral,0.14020618886250882,0.40454175015963706,0.06573487579210698,10.62925,1.0055533333333333,-0.29088129865823614,5.817401666666667,5.169184350670882,Uncertain,Uncertain,Destabilizing,Destabilizing,1.8623971224443217,0.39660130181565545,41.379,11.793,11.98,6.79,,False,41.379,,neutral,neutral,neutral,,False,11.98,,neutral,neutral,neutral,damaging,,-0.2595,0.1023,-22.2419,-4.77994467744306,0.8518424845510366,Pathogenic,0.9976,pathogenic,-4.201,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E180A,NP_000537:p.Glu180Ala,,,,,saturation_mutlist,,,,,,,,0.76302,0.4112661838531494,,0.7727684263939656,,0.7678942131969828,,Neutral,Neutral,,Neutral,0.2787339732441169,,0.23250502584069743,-0.05562,,0.7847797111081919,,0.36457985555409594,,Neutral,,Neutral,,0.31244640448568367,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.2742,0.5049,-22.2419,-4.24894450660188,0.4085367068285335,Uncertain,0.8966,pathogenic,-3.695,available,https://doi.org/10.1101/2022.10.22.513328 +E180C,NP_000537:p.Glu180Cys,,,,,saturation_mutlist,,,,,,,,1.16998,0.4309132790565491,,1.359027942917175,,1.2645039714585875,,Neutral,Neutral,,Neutral,0.24322233621347464,,0.17007713387919776,0.58394,,1.3847364833988884,,0.9843382416994442,,Neutral,,Neutral,,0.20741126105252747,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.3436,0.5049,-22.2419,-4.84480144585992,0.8201895045962253,Pathogenic,0.9957,pathogenic,-4.168,available,https://doi.org/10.1101/2022.10.22.513328 +E180D,NP_000537:p.Glu180Asp,"hg19,17:g.7578390C>A, hg19,17:g.7578390C>G, hg38,17:g.7675072C>A, hg38,17:g.7675072C>G",,,0.798,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","1521256, 1509915","Uncertain significance, Uncertain significance","2, 2",,,,,1.01514,0.5980303120613099,0.8088433333333334,0.8467299446856486,0.9119916666666666,0.9309349723428242,Neutral,Neutral,Neutral,Neutral,Neutral,0.2623331916671995,0.24632502015742444,0.2427260108388187,0.83756,1.2137166666666668,0.8258696813559605,1.0256383333333334,0.8317148406779802,Neutral,Neutral,Neutral,Neutral,0.3156958198787068,0.32450157619956527,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.2399,0.5049,-22.2419,-4.01310292969903,0.8680269035924145,Pathogenic,0.9843,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E180F,NP_000537:p.Glu180Phe,,,,,saturation_mutlist,,,,,,,,0.92697,0.5930647158622742,,0.12398151158363013,,0.525475755791815,,Neutral,Neutral,,Neutral,0.33439787942111787,,0.19612197364510375,1.21354,,0.33642466541291033,,0.7749823327064552,,Neutral,,Neutral,,0.3443304652473159,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.3212,0.5049,-22.2419,-7.17653783134478,0.8546346991778355,Pathogenic,0.9983,pathogenic,-4.302,available,https://doi.org/10.1101/2022.10.22.513328 +E180G,NP_000537:p.Glu180Gly,"hg19,17:g.7578391T>C, hg38,17:g.7675073T>C",,,0.915,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.51698,1.0673929643630982,1.9588433333333333,1.9263006816132062,1.7379116666666667,1.7216403408066032,Neutral,Neutral,Uncertain,Neutral,Neutral,0.33131979933563016,0.3753514385508896,0.28010971815527747,0.35563,1.9970533333333333,1.6397216479742263,1.1763416666666666,0.9976758239871131,Neutral,Neutral,Neutral,Neutral,0.25203440840929275,0.21771752533865388,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.3,0.5049,-22.2419,-7.17653783134478,0.8623303232396292,Pathogenic,0.9391,pathogenic,-4.038,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E180H,NP_000537:p.Glu180His,,,,,saturation_mutlist,,,,,,,,1.95176,0.6520179224014282,,0.4679332717219831,,1.2098466358609916,,Neutral,Neutral,,Neutral,0.2475998005610245,,0.14768445978032751,1.30565,,0.5463915659241986,,0.9260207829620992,,Neutral,,Neutral,,0.3585757276005624,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.3125,0.5049,-22.2419,-7.17653783134478,0.8690976436163388,Pathogenic,0.9961,pathogenic,-4.157,available,https://doi.org/10.1101/2022.10.22.513328 +E180I,NP_000537:p.Glu180Ile,,,,,saturation_mutlist,,,,,,,,0.81059,0.4629335761070251,,0.19344846726798257,,0.5020192336339913,,Neutral,Neutral,,Neutral,0.29850923469675517,,0.26771882903438404,0.2013,,0.2298101296159906,,0.2155550648079953,,Neutral,,Neutral,,0.19710625924823072,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.3265,0.5049,-22.2419,-4.60879661175175,0.5260646786796487,Uncertain,0.9876,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328 +E180K,NP_000537:p.Glu180Lys,"hg19,17:g.7578392C>T, hg19,17:g.7675074C>T, hg38,17:g.7675074C>T",,,0.823,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",245711,Likely pathogenic,3,,,,,0.93248,0.9461219382286071,1.3612266666666668,1.0133726492969715,1.1468533333333335,0.9729263246484857,Neutral,Neutral,Neutral,Neutral,Neutral,0.35985235316909053,0.7699582240759705,0.23959749170020275,0.26282,1.00771,0.9591614233850274,0.6352650000000001,0.6109907116925137,Neutral,Neutral,Neutral,Neutral,0.40972798155198864,0.3493686298893483,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.2962,0.5049,-22.2419,-4.89923646247751,0.3452811995524725,Uncertain,0.9545,pathogenic,-3.778,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E180L,NP_000537:p.Glu180Leu,,,,,saturation_mutlist,,,,,,,,-0.29072,0.5924082589149475,,-0.07685640618848451,,-0.18378820309424224,,Neutral,Neutral,,Neutral,0.24996454709955257,,0.2772910383654528,-0.19191,,-0.04684865535166933,,-0.11937932767583466,,Neutral,,Neutral,,0.13430508127214713,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.2609,0.5049,-8.9541,-5.14403974319505,0.5822336053576234,Uncertain,0.9876,pathogenic,-3.893,available,https://doi.org/10.1101/2022.10.22.513328 +E180M,NP_000537:p.Glu180Met,,,,,saturation_mutlist,,,,,,,,-0.0975,0.5213738107681274,,0.28638771831444026,,0.09444385915722013,,Neutral,Neutral,,Neutral,0.22229282042638512,,0.20927097795933006,-0.33737,,0.31863676931669693,,-0.009366615341651535,,Neutral,,Neutral,,0.21894932993829563,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.2775,0.5049,-22.2419,-4.68654595280717,0.5819912889764463,Uncertain,0.9785,pathogenic,-3.974,available,https://doi.org/10.1101/2022.10.22.513328 +E180N,NP_000537:p.Glu180Asn,,,,,saturation_mutlist,,,,,,,,1.5471,0.9422546696662902,,0.8828099832055051,,1.2149549916027524,,Neutral,Neutral,,Neutral,0.25323267758868484,,0.20193109539922255,1.02663,,0.8228703497185711,,0.9247501748592855,,Neutral,,Neutral,,0.263291443727892,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.3004,0.5049,-22.2419,-3.81278750080609,0.8698214707781948,Pathogenic,0.9947,pathogenic,-4.195,available,https://doi.org/10.1101/2022.10.22.513328 +E180P,NP_000537:p.Glu180Pro,,,,,saturation_mutlist,,,,,,,,5.39139,1.5631774377822876,,5.060280839001419,,5.22583541950071,,Destabilizing,Uncertain,,Destabilizing,0.3646774406249773,,0.6542185423392187,5.77237,,4.799879418310031,,5.286124709155015,,Destabilizing,,Destabilizing,,1.935945118408843,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.4312,0.5049,-22.2419,-7.17653783134478,0.8691903460644173,Pathogenic,0.9995,pathogenic,-4.286,available,https://doi.org/10.1101/2022.10.22.513328 +E180Q,NP_000537:p.Glu180Gln,"hg19,17:g.7675074C>G, hg38,17:g.7675074C>G",,,0.659,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.83628,0.43334914088249205,0.18968333333333334,0.675948066997942,0.5129816666666667,0.756114033498971,Neutral,Neutral,Neutral,Neutral,Neutral,0.267264969748864,0.3718743108751785,0.1595188983624806,0.32885,0.3230166666666667,0.7127987404484081,0.3259333333333333,0.520824370224204,Neutral,Neutral,Neutral,Neutral,0.2751032738607247,0.29661508251315755,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.1498,0.5049,-3.2538,-1.95332187981058,0.0001743311622279,Benign,0.6972,pathogenic,-3.327,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E180R,NP_000537:p.Glu180Arg,,,,,saturation_mutlist,,,,,,,,1.37367,0.9055135822296143,,0.6619423817464004,,1.0178061908732001,,Neutral,Neutral,,Neutral,0.3445203081512719,,0.2579937904745524,0.61944,,0.5767693337240728,,0.5981046668620364,,Neutral,,Neutral,,0.3425807330029695,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.3567,0.5049,-22.2419,-4.93206584285295,0.5420297420236151,Uncertain,0.9686,pathogenic,-3.83,available,https://doi.org/10.1101/2022.10.22.513328 +E180S,NP_000537:p.Glu180Ser,,,,,saturation_mutlist,,,,,,,,1.38693,0.7115175867080689,,1.3031474338082096,,1.3450387169041047,,Neutral,Neutral,,Neutral,0.2545274857073956,,0.20947553234820301,0.52785,,1.1530404248529516,,0.8404452124264759,,Neutral,,Neutral,,0.32165144970532294,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.2877,0.5049,-22.2419,-4.40461122679346,0.3506083855064047,Uncertain,0.939,pathogenic,-3.79,available,https://doi.org/10.1101/2022.10.22.513328 +E180T,NP_000537:p.Glu180Thr,,,,,saturation_mutlist,,,,,,,,1.31897,0.69950519323349,,0.8845843568386483,,1.1017771784193242,,Neutral,Neutral,,Neutral,0.2411956428565105,,0.28228307755588444,0.88823,,0.8339155582607379,,0.861072779130369,,Neutral,,Neutral,,0.25630099303741877,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.3035,0.5049,-22.2419,-4.13869447516391,0.6174368821993717,Uncertain,0.9784,pathogenic,-3.847,available,https://doi.org/10.1101/2022.10.22.513328 +E180V,NP_000537:p.Glu180Val,,,,,saturation_mutlist,,,,,,,,0.88919,0.43444500207901,,0.4108273620170278,,0.6500086810085139,,Neutral,Neutral,,Neutral,0.32132083127766986,,0.24013642407284166,0.38089,,0.419043979367365,,0.3999669896836825,,Neutral,,Neutral,,0.26592580757371104,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.2874,0.5049,-22.2419,-4.6438588596269,0.4989284553408514,Uncertain,0.9619,pathogenic,-3.828,available,https://doi.org/10.1101/2022.10.22.513328 +E180W,NP_000537:p.Glu180Trp,,,,,saturation_mutlist,,,,,,,,0.88412,0.40720042228698733,,-0.2244747244473392,,0.3298226377763304,,Neutral,Neutral,,Neutral,0.29146306058180355,,0.16175141000343504,1.26725,,-0.007588040378931404,,0.6298309798105343,,Neutral,,Neutral,,0.4333950652798284,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.3313,0.5049,-22.2419,-7.17653783134478,0.8483671215329049,Pathogenic,0.9995,pathogenic,-4.451,available,https://doi.org/10.1101/2022.10.22.513328 +E180Y,NP_000537:p.Glu180Tyr,,,,,saturation_mutlist,,,,,,,,1.21941,0.4195873498916626,,0.34642941881991396,,0.782919709409957,,Neutral,Neutral,,Neutral,0.34070246884859917,,0.14684244262115254,1.0995,,0.474277934482948,,0.786888967241474,,Neutral,,Neutral,,0.3724698898113678,19.762,12.281,44.6,11.19,,False,19.762,,neutral,neutral,neutral,,False,44.6,,neutral,neutral,neutral,uncertain,,-0.322,0.5049,-22.2419,-7.17653783134478,0.8708251560894527,Pathogenic,0.9977,pathogenic,-4.379,available,https://doi.org/10.1101/2022.10.22.513328 +R181A,NP_000537:p.Arg181Ala,,,,,saturation_mutlist,,,,,,,,0.69215,-0.11667644023895261,,0.573535905798757,,0.6328429528993785,,Neutral,Neutral,,Neutral,0.0818762543295125,,0.05015216354948636,-0.17796,,0.42534343461562657,,0.12369171730781328,,Neutral,,Neutral,,0.023986474480145712,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.2828,1.3753,-22.1457,-2.99280489319979,0.0619878403162466,Benign,0.9365,pathogenic,-3.692,available,https://doi.org/10.1101/2022.10.22.513328 +R181C,NP_000537:p.Arg181Cys,"hg19,17:g.7578389G>A, hg19,17:g.7675071G>A, hg38,17:g.7675066_7675071delinsACAGCA, hg38,17:g.7675071G>A",,,0.891,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142624,Likely pathogenic,3,Likely oncogenic,1,Tier I - Strong,1,0.80679,-0.3793389296531677,0.6903633333333333,1.000810253571048,0.7485766666666667,0.903800126785524,Neutral,Neutral,Neutral,Neutral,Neutral,0.13923230341087944,0.111312213865126,0.07553372618534654,0.4101,0.5925133333333333,1.0890169195827977,0.5013066666666667,0.7495584597913989,Neutral,Neutral,Neutral,Neutral,0.05969725919634464,0.023993378838304148,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.2121,1.3753,-6.536,-1.68475225689632,0.000101097600815,Benign,0.7821,pathogenic,-3.339,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R181D,NP_000537:p.Arg181Asp,,,,,saturation_mutlist,,,,,,,,0.70492,0.09358372449874879,,0.3863035087803999,,0.5456117543901999,,Neutral,Neutral,,Neutral,0.12496809122364559,,0.07616590432758803,0.00177,,0.3921570665838267,,0.19696353329191335,,Neutral,,Neutral,,0.1246284309204625,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.3739,1.3753,-22.1457,-3.56772637753279,0.030766082322392,Benign,0.969,pathogenic,-3.941,available,https://doi.org/10.1101/2022.10.22.513328 +R181E,NP_000537:p.Arg181Glu,,,,,saturation_mutlist,,,,,,,,0.68411,0.012037944793701173,,0.40701189781475006,,0.545560948907375,,Neutral,Neutral,,Neutral,0.1452318228718082,,0.02481692271086794,-0.08314,,0.19465674177021863,,0.055758370885109314,,Neutral,,Neutral,,0.08401613979313438,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.2513,1.3753,-8.8578,-3.46318427497821,0.1114022919730102,Benign,0.918,pathogenic,-3.844,available,https://doi.org/10.1101/2022.10.22.513328 +R181F,NP_000537:p.Arg181Phe,,,,,saturation_mutlist,,,,,,,,0.00962,-0.11424428224563599,,0.1445320759216828,,0.07707603796084139,,Neutral,Neutral,,Neutral,0.20031543952326697,,0.02172927345599638,-0.21873,,0.08018795943655731,,-0.06927102028172136,,Neutral,,Neutral,,0.059686229990024244,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.315,1.3753,-22.1457,-4.74866784766429,0.1690713846894409,Benign,0.9698,pathogenic,-3.8,available,https://doi.org/10.1101/2022.10.22.513328 +R181G,NP_000537:p.Arg181Gly,"hg38,17:g.7675071G>C",,,0.886,"COSMIC,saturation_mutlist",,,,,,,,0.58934,0.07467904567718504,0.7789133333333332,0.9323962514957941,0.6841266666666665,0.7608681257478971,Neutral,Neutral,Neutral,Neutral,Neutral,0.14927855910876375,0.210635446420798,0.2768493486674242,-0.32233,0.7638333333333334,0.9701978207725838,0.22075166666666668,0.3239339103862919,Neutral,Neutral,Neutral,Neutral,0.12196100041497783,0.04782787273984278,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.3182,1.3753,-22.1457,-3.40908290573761,0.107222187780725,Benign,0.8319,pathogenic,-3.671,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R181H,NP_000537:p.Arg181His,"hg19,17:g.7578388C>T, hg19,17:g.7675070C>T, hg38,17:g.7675070C>T",3.1843077315e-05,1.19367827983e-05,0.797,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142320,Pathogenic/Likely pathogenic,2,,,,,0.33734,-0.17999683380126952,0.14637,0.06361849904065484,0.241855,0.20047924952032742,Neutral,Neutral,Neutral,Neutral,Neutral,0.18011929012769984,0.2235000601043916,0.04969693043616623,0.25649,-0.03798333333333331,0.048263437402785735,0.10925333333333334,0.15237671870139285,Neutral,Neutral,Neutral,Neutral,0.3270108097431779,0.06868578952313403,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,destabilizing,-0.2526,1.3753,-22.1457,-4.6132577539881,0.3965586030513996,Uncertain,0.5897,pathogenic,-3.598,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R181I,NP_000537:p.Arg181Ile,,,,,saturation_mutlist,,,,,,,,0.8812,0.11219801425933836,,0.44872718106837334,,0.6649635905341866,,Neutral,Neutral,,Neutral,0.18962284727240025,,0.22809313931646333,0.26785,,0.1290648685672272,,0.1984574342836136,,Neutral,,Neutral,,0.06774651905829052,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.3123,1.3753,-22.1457,-1.85661734121558,0.0897232349098313,Benign,0.8978,pathogenic,-3.77,available,https://doi.org/10.1101/2022.10.22.513328 +R181K,NP_000537:p.Arg181Lys,,,,,saturation_mutlist,,,,,,,,0.16346,-0.01786649465560912,,0.20247317246889163,,0.1829665862344458,,Neutral,Neutral,,Neutral,0.027768340987704317,,0.11029741061984129,-0.04839,,0.12772776777852968,,0.03966888388926484,,Neutral,,Neutral,,0.0410512314358283,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.0972,1.3753,-7.273,-1.81007855970178,0.0004786670712739,Benign,0.5021,ambiguous,-3.337,available,https://doi.org/10.1101/2022.10.22.513328 +R181L,NP_000537:p.Arg181Leu,"hg19,17:g.7578388C>A, hg38,17:g.7675070C>A",,,0.680,"COSMIC,ClinVar,saturation_mutlist",39420,Conflicting classifications of pathogenicity,1,,,,,0.25853,-0.14062217473983765,-0.12653,-0.1027640804460372,0.06599999999999999,0.0778829597769814,Neutral,Neutral,Neutral,Neutral,Neutral,0.09874147042426984,0.41390875572602553,0.05388389110433343,-0.04706,-0.10929666666666667,-0.22667301764202277,-0.07817833333333334,-0.1368665088210114,Neutral,Neutral,Neutral,Neutral,0.1322290803450167,0.05938373251380051,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.1811,1.3753,-1.7184,-1.78372764631026,0.0043008187038406,Benign,0.7789,pathogenic,-3.412,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R181M,NP_000537:p.Arg181Met,,,,,saturation_mutlist,,,,,,,,0.25296,-0.07365809440612792,,0.20666018577628473,,0.22981009288814236,,Neutral,Neutral,,Neutral,0.061401624133910454,,0.04655474231695713,-0.15165,,0.0958991340800378,,-0.0278754329599811,,Neutral,,Neutral,,0.027306306298101716,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.2511,1.3753,-22.1457,-2.83108413970769,0.1861717151039591,Benign,0.92,pathogenic,-3.786,available,https://doi.org/10.1101/2022.10.22.513328 +R181N,NP_000537:p.Arg181Asn,,,,,saturation_mutlist,,,,,,,,0.24389,-0.18669067144393917,,0.21265611228660586,,0.22827305614330293,,Neutral,Neutral,,Neutral,0.14311666421950797,,0.10797869479610185,0.10816,,0.32457009357013805,,0.21636504678506902,,Neutral,,Neutral,,0.051890254203387116,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.2146,1.3753,-5.858,-2.40137883804777,0.0002277299330921,Benign,0.9303,pathogenic,-3.434,available,https://doi.org/10.1101/2022.10.22.513328 +R181P,NP_000537:p.Arg181Pro,"hg19,17:g.7578388C>G, hg19,17:g.7675070C>G, hg38,17:g.7675070C>G",,,0.894,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",825729,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,3.04802,0.9001771855354309,5.0369633333333335,4.326882122916716,4.042491666666667,3.687451061458358,Destabilizing,Destabilizing,Neutral,Destabilizing,Destabilizing,0.29684297588527825,0.5877809650050109,0.17361604206095482,2.36753,5.851473333333334,4.06026686332441,4.109501666666667,3.213898431662205,Uncertain,Uncertain,Destabilizing,Destabilizing,2.51776064508832,1.8208165128776737,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.4249,1.3753,-22.1457,-5.89424882966398,0.7018334935995721,Pathogenic,0.9881,pathogenic,-4.159,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R181Q,NP_000537:p.Arg181Gln,,,,,saturation_mutlist,,,,,,,,0.17029,0.006242861747741703,,0.4834641814446307,,0.32687709072231536,,Neutral,Neutral,,Neutral,0.0696399131986178,,0.08498342795681939,-0.03455,,0.3651442267061527,,0.16529711335307634,,Neutral,,Neutral,,0.03860017847541384,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.1817,1.3753,-7.273,-2.10064191078992,0.0055681241093766,Benign,0.5038,ambiguous,-3.462,available,https://doi.org/10.1101/2022.10.22.513328 +R181S,NP_000537:p.Arg181Ser,"hg19,17:g.7578389G>T, hg38,17:g.7675071G>T",,,0.778,"COSMIC,ClinVar,saturation_mutlist",230764,Uncertain significance,3,,,,,0.56483,-0.09832932472229002,0.2592966666666667,0.5452995554245597,0.41206333333333334,0.5550647777122799,Neutral,Neutral,Neutral,Neutral,Neutral,0.11115197033263374,0.14730450758736324,0.10255889117693635,0.20335,0.06814333333333333,0.5705505051561787,0.13574666666666668,0.38695025257808935,Neutral,Neutral,Neutral,Neutral,0.08084797640565215,0.1726420001283209,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.2003,1.3753,-5.858,-1.95985419143055,0.0001757125516154,Benign,0.9524,pathogenic,-3.302,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R181T,NP_000537:p.Arg181Thr,,,,,saturation_mutlist,,,,,,,,0.92923,-0.006060372591018686,,0.46997539837599245,,0.6996026991879962,,Neutral,Neutral,,Neutral,0.16453950489588037,,0.08056273853702392,0.36112,,0.41470788560023136,,0.3879139428001157,,Neutral,,Neutral,,0.10927104935861608,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.2118,1.3753,-7.273,-2.36815356608492,0.0159835905115538,Benign,0.9137,pathogenic,-3.516,available,https://doi.org/10.1101/2022.10.22.513328 +R181V,NP_000537:p.Arg181Val,,,,,saturation_mutlist,,,,,,,,1.19001,0.16726167917251586,,0.46396042368027685,,0.8269852118401384,,Neutral,Neutral,,Neutral,0.1932647767402227,,0.13611333116734733,0.46849,,0.2708341987997514,,0.3696620993998757,,Neutral,,Neutral,,0.04086476791392912,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.2993,1.3753,-22.1457,-2.5224692505029,0.115550468681366,Benign,0.9178,pathogenic,-3.764,available,https://doi.org/10.1101/2022.10.22.513328 +R181W,NP_000537:p.Arg181Trp,,,,,saturation_mutlist,,,,,,,,0.38408,-0.144001190662384,,-0.07635474308054167,,0.15386262845972914,,Neutral,Neutral,,Neutral,0.19738235119252243,,0.10005741555555125,0.1178,,-0.38647164747205603,,-0.134335823736028,,Neutral,,Neutral,,0.07937884671924171,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.3006,1.3753,-22.1457,-5.03969650820416,0.6411163165895126,Uncertain,0.8386,pathogenic,-4.079,available,https://doi.org/10.1101/2022.10.22.513328 +R181Y,NP_000537:p.Arg181Tyr,,,,,"COSMIC,saturation_mutlist",,,,,,,,0.14938,-0.21761325836181641,0.07573666666666667,0.25895583198818567,0.11255833333333334,0.20416791599409284,Neutral,Neutral,Neutral,Neutral,Neutral,0.23412535132605042,0.3915214104263293,0.020708308305262733,-0.12802,-0.12007,0.12255298090921556,-0.12404499999999999,-0.0027335095453922195,Neutral,Neutral,Neutral,Neutral,0.36747904493544475,0.07033920681515744,78.107,9.459,86.88,8.008,,True,78.107,,neutral,neutral,neutral,,True,86.88,,neutral,neutral,neutral,uncertain,,-0.3043,1.3753,-22.1457,-4.7566485774957,0.3591119399125625,Uncertain,0.9175,pathogenic,-3.899,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C182A,NP_000537:p.Cys182Ala,,,,,saturation_mutlist,,,,,,,,-0.02863,-0.04757617235183715,,0.002566471518090104,,-0.013031764240954948,,Neutral,Neutral,,Neutral,0.18810522522854561,,0.10642798549007551,-0.18879,,-0.3692313316796028,,-0.2790106658398014,,Neutral,,Neutral,,0.09052979680408048,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.1743,2.5602,-6.0413,-1.40169309573315,7.640333182724883e-07,Benign,0.303,benign,-3.03,available,https://doi.org/10.1101/2022.10.22.513328 +C182D,NP_000537:p.Cys182Asp,,,,,saturation_mutlist,,,,,,,,-0.12199,0.16070698261260985,,0.6147447855746068,,0.2463773927873034,,Neutral,Neutral,,Neutral,0.13078937085279202,,0.23572018136634523,-0.37069,,-0.15421795647799877,,-0.2624539782389994,,Neutral,,Neutral,,0.12206178493448001,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.3637,2.5602,-22.1363,-3.64964588715357,0.0337831422603337,Benign,0.6467,pathogenic,-3.4,available,https://doi.org/10.1101/2022.10.22.513328 +C182E,NP_000537:p.Cys182Glu,,,,,saturation_mutlist,,,,,,,,0.05419,0.16316592931747437,,0.1632155977735198,,0.1087027988867599,,Neutral,Neutral,,Neutral,0.18742394986165706,,0.12338408715405236,-0.31846,,-0.3368702891546887,,-0.32766514457734436,,Neutral,,Neutral,,0.14168112762176815,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.247,2.5602,-1.6989,-2.61964780497236,9.259827978399064e-05,Benign,0.8029,pathogenic,-3.2,available,https://doi.org/10.1101/2022.10.22.513328 +C182F,NP_000537:p.Cys182Phe,,,,,saturation_mutlist,,,,,,,,-0.18009,0.2893554925918579,,-0.7138860743481358,,-0.4469880371740679,,Neutral,Neutral,,Neutral,0.1031953599498534,,0.22177606096112018,-0.49332,,-0.7551294693352739,,-0.624224734667637,,Neutral,,Neutral,,0.05281824310593838,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.1826,2.5602,-8.8485,-4.62916087876924,0.1083533310360335,Benign,0.2808,benign,-3.679,available,https://doi.org/10.1101/2022.10.22.513328 +C182G,NP_000537:p.Cys182Gly,"hg19,17:g.7578386A>C, hg38,17:g.7675068A>C",,,0.644,"ClinVar,saturation_mutlist",1489700,Uncertain significance,1,,,,,0.29062,0.2521113336086273,0.9595266666666666,1.3261489773111077,0.6250733333333334,0.8083844886555538,Neutral,Neutral,Neutral,Neutral,Neutral,0.20087344623413006,0.3612583143526096,0.32064748384350306,-0.36786,1.0240366666666667,0.25486147378942664,0.3280883333333333,-0.05649926310528669,Neutral,Neutral,Neutral,Neutral,0.320085041859538,0.13670731527350058,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.1494,2.5602,-2.6392,-2.06513563086665,2.313041774144643e-06,Benign,0.1252,benign,-3.152,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C182H,NP_000537:p.Cys182His,,,,,saturation_mutlist,,,,,,,,0.22249,0.1541184329986572,,-0.22114269498775188,,0.0006736525061240561,,Neutral,Neutral,,Neutral,0.07612607203385578,,0.2692967354771547,-0.17087,,-0.6670967441489015,,-0.41898337207445074,,Neutral,,Neutral,,0.05581447821041743,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.2892,2.5602,-7.8486,-3.21479375180572,0.0010122956634087,Benign,0.56,ambiguous,-3.327,available,https://doi.org/10.1101/2022.10.22.513328 +C182I,NP_000537:p.Cys182Ile,,,,,saturation_mutlist,,,,,,,,0.61378,0.13196238040924071,,-0.6422859755266616,,-0.014252987763330782,,Neutral,Neutral,,Neutral,0.23819452352502465,,0.09114088737849817,0.27875,,-0.6497277856585563,,-0.18548889282927813,,Neutral,,Neutral,,0.26316547583551486,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.1981,2.5602,-6.0413,-2.69484183510495,3.757687414509226e-06,Benign,0.5509,ambiguous,-3.27,available,https://doi.org/10.1101/2022.10.22.513328 +C182K,NP_000537:p.Cys182Lys,,,,,saturation_mutlist,,,,,,,,-0.36854,-0.055669348239898664,,0.24084026594953653,,-0.06384986702523172,,Neutral,Neutral,,Neutral,0.2041908794048572,,0.16900407974807777,-0.37484,,-0.49076138873449365,,-0.43280069436724683,,Neutral,,Neutral,,0.1046741554262829,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.2841,2.5602,-8.8485,-3.9008857468304,0.0014970021626311,Benign,0.8636,pathogenic,-3.284,available,https://doi.org/10.1101/2022.10.22.513328 +C182L,NP_000537:p.Cys182Leu,,,,,saturation_mutlist,,,,,,,,-0.22569,-0.005375068187713623,,-1.1802226425500297,,-0.7029563212750148,,Neutral,Neutral,,Neutral,0.19963265955848708,,0.16065964369975969,-0.4426,,-1.2120232556530142,,-0.8273116278265071,,Neutral,,Neutral,,0.09292478278943592,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.3133,2.5602,-22.1363,-3.68642896791747,0.0036471676624154,Benign,0.4904,ambiguous,-3.306,available,https://doi.org/10.1101/2022.10.22.513328 +C182M,NP_000537:p.Cys182Met,,,,,saturation_mutlist,,,,,,,,-0.30406,-0.03896841049194335,,-0.7358824236516875,,-0.5199712118258437,,Neutral,Neutral,,Neutral,0.19408158887410007,,0.1738758787525424,-0.46114,,-0.7920666856373245,,-0.6266033428186623,,Neutral,,Neutral,,0.07185239770787215,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.2806,2.5602,-22.1363,-3.79588949024381,0.0094789820175674,Benign,0.5763,pathogenic,-3.371,available,https://doi.org/10.1101/2022.10.22.513328 +C182N,NP_000537:p.Cys182Asn,,,,,saturation_mutlist,,,,,,,,-0.21396,0.02543716192245483,,0.01840216685685773,,-0.09777891657157115,,Neutral,Neutral,,Neutral,0.12334419462150942,,0.164157299164937,-0.30515,,-0.4532521183153273,,-0.37920105915766367,,Neutral,,Neutral,,0.17412766979915872,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.2302,2.5602,-7.2636,-2.11975898210649,2.508595334841552e-06,Benign,0.2772,benign,-3.078,available,https://doi.org/10.1101/2022.10.22.513328 +C182P,NP_000537:p.Cys182Pro,,,,,saturation_mutlist,,,,,,,,3.52078,1.1181804728507996,,3.3233095529015464,,3.422044776450773,,Destabilizing,Uncertain,,Destabilizing,0.29578347276147254,,1.622506553110516,3.61093,,4.563978524171397,,4.087454262085698,,Destabilizing,,Destabilizing,,0.5729257028186592,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.3747,2.5602,-22.1363,-3.37186841537745,0.0048656164633919,Benign,0.8677,pathogenic,-3.251,available,https://doi.org/10.1101/2022.10.22.513328 +C182Q,NP_000537:p.Cys182Gln,,,,,saturation_mutlist,,,,,,,,-0.18587,-0.13658233642578124,,-0.1026858639996495,,-0.14427793199982475,,Neutral,Neutral,,Neutral,0.2242969734899303,,0.014411276949375908,-0.23451,,-0.3988766941887963,,-0.3166933470943981,,Neutral,,Neutral,,0.12450615753939123,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.2622,2.5602,-8.8485,-2.67364994098795,0.0004155100475135,Benign,0.6167,pathogenic,-3.247,available,https://doi.org/10.1101/2022.10.22.513328 +C182R,NP_000537:p.Cys182Arg,"hg19,17:g.7578386A>G, hg38,17:g.7675068A>G",,,0.644,"COSMIC,ClinVar,saturation_mutlist",2774651,Uncertain significance,1,,,,,-0.50035,-0.02184437990188597,-0.31825333333333333,-0.3063960594160621,-0.4093016666666667,-0.403373029708031,Neutral,Neutral,Neutral,Neutral,Neutral,0.20636258220432702,0.8733443514190469,0.18710964753808618,-0.27656,-0.9783466666666666,-0.8421611188624728,-0.6274533333333333,-0.5593605594312364,Neutral,Neutral,Neutral,Neutral,0.38414406519198263,0.059388547433797914,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.2328,2.5602,-7.2636,-2.38440899215391,3.3750833254013484e-06,Benign,0.577,pathogenic,-2.999,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C182S,NP_000537:p.Cys182Ser,"hg19,17:g.7578386A>T, hg38,17:g.7675067C>G, hg38,17:g.7675068A>T",,,"0.438, 0.455","COSMIC,ClinVar,saturation_mutlist",3572141,Uncertain significance,1,,,,,-0.06702,-0.02646680831909178,0.17018000000000003,0.6836249904038286,0.051580000000000015,0.30830249520191433,Neutral,Neutral,Neutral,Neutral,Neutral,0.1857846217193559,0.6576217341805748,0.19136757230747548,-0.0658,0.001813333333333331,-0.05613786124489,-0.03199333333333333,-0.060968930622445,Neutral,Neutral,Neutral,Neutral,0.0901765573133555,0.017217681094305742,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.1458,2.5602,-2.2788,-0.344315653188998,1.3941014372976027e-11,Benign,0.1432,benign,-2.836,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C182T,NP_000537:p.Cys182Thr,,,,,saturation_mutlist,,,,,,,,0.28787,0.06718804597854612,,0.18333402815505254,,0.2356020140775263,,Neutral,Neutral,,Neutral,0.20696828497165046,,0.2258531933028548,0.52031,,-0.15472574919769275,,0.18279212540115364,,Neutral,,Neutral,,0.10186548669512098,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.1898,2.5602,-4.0937,-1.33982175602423,1.0723087595584234e-07,Benign,0.2763,benign,-2.957,available,https://doi.org/10.1101/2022.10.22.513328 +C182V,NP_000537:p.Cys182Val,,,,,saturation_mutlist,,,,,,,,0.76628,0.18526177406311034,,-0.4313369686683151,,0.16747151566584242,,Neutral,Neutral,,Neutral,0.2258650750129993,,0.10483729293576959,0.55268,,-0.5665077681208434,,-0.0069138840604217044,,Neutral,,Neutral,,0.1662924122894336,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.2024,2.5602,-7.2636,-2.78982489009814,0.0001042574263544,Benign,0.3973,ambiguous,-3.212,available,https://doi.org/10.1101/2022.10.22.513328 +C182W,NP_000537:p.Cys182Trp,"hg19,17:g.7578384G>C, hg38,17:g.7675066G>C",,,0.659,"COSMIC,ClinVar,saturation_mutlist",423137,Uncertain significance,2,,,,,0.12752,0.3408293128013611,0.03231333333333338,-0.8953045728213521,0.07991666666666669,-0.3838922864106761,Neutral,Neutral,Neutral,Neutral,Neutral,0.10552879120520924,0.7965754191677159,0.22313316640480735,-0.19087,-0.5679133333333333,-1.1343499850414895,-0.3793916666666666,-0.6626099925207448,Neutral,Neutral,Neutral,Neutral,0.3441659449871368,0.1102221780428376,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.2535,2.5602,-22.1363,-4.62916087876924,0.2466861246727657,Benign,0.6232,pathogenic,-3.77,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C182Y,NP_000537:p.Cys182Tyr,"hg38,17:g.7675067C>T",,,0.634,"COSMIC,saturation_mutlist",,,,,,,,-0.06463,0.3945618999004364,0.07415333333333333,-0.3792436609009917,0.004761666666666664,-0.22193683045049586,Neutral,Neutral,Neutral,Neutral,Neutral,0.12445752445558383,0.795149116846785,0.20924829441666412,-0.47147,-0.5166666666666667,-0.6147677547851785,-0.49406833333333333,-0.5431188773925892,Neutral,Neutral,Neutral,Neutral,0.667918338438332,0.1288394481636356,48.348,18.57,65.1,15.756,,True,48.348,,neutral,neutral,neutral,,True,65.1,,neutral,neutral,neutral,uncertain,,-0.1919,2.5602,-8.8485,-4.62916087876924,0.0065436094973952,Benign,0.4342,ambiguous,-3.495,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S183A,NP_000537:p.Ser183Ala,,,,,saturation_mutlist,,,,,,,,0.09807,0.09522532224655152,,0.4548873510285991,,0.27647867551429955,,Neutral,Neutral,,Neutral,0.11590079024024685,,0.21905915895372302,-0.18249,,0.1473713930663439,,-0.01755930346682806,,Neutral,,Neutral,,0.13722960114353588,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,0.0407,2.5172,-4.6818,-1.50041483373061,8.08465906524806e-07,Benign,0.0844,benign,-2.991,available,https://doi.org/10.1101/2022.10.22.513328 +S183C,NP_000537:p.Ser183Cys,,,,,saturation_mutlist,,,,,,,,0.31694,0.0036707139015197676,,0.9581898189394823,,0.6375649094697411,,Neutral,Neutral,,Neutral,0.06691734871934224,,0.10465392831751205,-0.10204,,0.6035519689776357,,0.25075598448881786,,Neutral,,Neutral,,0.13636766286786642,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.0988,2.5172,-22.1395,-1.40670628281605,0.0293441388240085,Benign,0.1329,benign,-3.48,available,https://doi.org/10.1101/2022.10.22.513328 +S183D,NP_000537:p.Ser183Asp,,,,,saturation_mutlist,,,,,,,,-0.00856,0.11999785423278807,,-0.038124825055483466,,-0.023342412527741732,,Neutral,Neutral,,Neutral,0.13420340336370756,,0.1320002129872016,0.68163,,0.15202946160609787,,0.4168297308030489,,Neutral,,Neutral,,0.4364065147356636,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.0649,2.5172,-6.0444,-0.92525206734369,9.836407936122858e-06,Benign,0.5895,pathogenic,-3.133,available,https://doi.org/10.1101/2022.10.22.513328 +S183E,NP_000537:p.Ser183Glu,,,,,saturation_mutlist,,,,,,,,-0.01997,0.167039897441864,,0.11944974266803743,,0.04973987133401871,,Neutral,Neutral,,Neutral,0.08769853305484636,,0.21094908259285078,0.62652,,0.10819718085575626,,0.3673585904278781,,Neutral,,Neutral,,0.388837348413,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.0355,2.5172,-5.5298,-1.90539837217322,0.0002356916117145,Benign,0.6969,pathogenic,-3.282,available,https://doi.org/10.1101/2022.10.22.513328 +S183F,NP_000537:p.Ser183Phe,,,,,saturation_mutlist,,,,,,,,0.07798,0.2660678386688232,,0.01964915191681903,,0.04881457595840951,,Neutral,Neutral,,Neutral,0.12541528968429808,,0.14535133844217865,1.50404,,-0.46010417139485127,,0.5219679143025744,,Neutral,,Neutral,,0.17718278115077657,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.0222,2.5172,-1.7225,-4.67543076910183,0.1651011140202038,Benign,0.3462,ambiguous,-3.756,available,https://doi.org/10.1101/2022.10.22.513328 +S183G,NP_000537:p.Ser183Gly,,,,,saturation_mutlist,,,,,,,,0.1209,0.23062198400497436,,0.6672610180223923,,0.3940805090111962,,Neutral,Neutral,,Neutral,0.13003258444541105,,0.10962511534059419,-0.76407,,0.5675864245146017,,-0.09824178774269915,,Neutral,,Neutral,,0.2448253951089527,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,0.0246,2.5172,-6.0444,-2.36193507984271,4.226465861858864e-06,Benign,0.0997,benign,-3.104,available,https://doi.org/10.1101/2022.10.22.513328 +S183H,NP_000537:p.Ser183His,,,,,saturation_mutlist,,,,,,,,0.14078,0.1884986424446106,,-0.0745142556741988,,0.033132872162900597,,Neutral,Neutral,,Neutral,0.11588306074615363,,0.10299757447598587,1.72706,,-0.4375668172468898,,0.6447465913765551,,Neutral,,Neutral,,0.2235957052318957,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.1276,2.5172,-22.1395,-4.40292473143752,0.0002054561086059,Benign,0.5481,ambiguous,-3.47,available,https://doi.org/10.1101/2022.10.22.513328 +S183I,NP_000537:p.Ser183Ile,,,,,saturation_mutlist,,,,,,,,0.2225,0.23520010352134704,,0.30308877099507553,,0.26279438549753775,,Neutral,Neutral,,Neutral,0.11624917358964425,,0.26204034537191906,1.0182,,-0.15975075590455967,,0.42922462204772016,,Neutral,,Neutral,,0.2198764133446145,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.1295,2.5172,-22.1395,-3.72579747263335,0.0299087116066322,Benign,0.302,benign,-3.579,available,https://doi.org/10.1101/2022.10.22.513328 +S183K,NP_000537:p.Ser183Lys,,,,,saturation_mutlist,,,,,,,,-0.23776,0.1484205186367035,,0.24564311778667594,,0.003941558893337971,,Neutral,Neutral,,Neutral,0.12899083510077747,,0.1466342134539204,0.4789,,-0.18278635113753497,,0.14805682443123253,,Neutral,,Neutral,,0.25977420708984805,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.137,2.5172,-22.1395,-1.63696792972833,0.0022530878462351,Benign,0.8672,pathogenic,-3.439,available,https://doi.org/10.1101/2022.10.22.513328 +S183L,NP_000537:p.Ser183Leu,"hg19,17:g.7578382G>A, hg38,17:g.7675064G>A",,,0.556,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480735,Conflicting classifications of pathogenicity,1,,,,,-0.04014,0.1988162541389465,0.93492,-0.08796574921440296,0.44739,-0.06405287460720148,Neutral,Neutral,Neutral,Neutral,Neutral,0.09581284286796075,0.7426345311569256,0.14671372968783747,0.45631,0.38412666666666667,-0.7397514254081047,0.42021833333333336,-0.14172071270405234,Neutral,Neutral,Neutral,Neutral,0.3201110757568726,0.18056751003676685,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.0529,2.5172,-7.8517,-1.1839784203177,0.0011439951820378,Benign,0.1353,benign,-3.347,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S183M,NP_000537:p.Ser183Met,,,,,saturation_mutlist,,,,,,,,0.41856,0.258162248134613,,0.1890668473424371,,0.30381342367121855,,Neutral,Neutral,,Neutral,0.09786588629332543,,0.16771704856177325,0.0745,,-0.31134045666068716,,-0.11842022833034357,,Neutral,,Neutral,,0.1709194632506827,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.0239,2.5172,-7.8517,-2.50927661332166,0.0003663828388805,Benign,0.2572,benign,-3.516,available,https://doi.org/10.1101/2022.10.22.513328 +S183N,NP_000537:p.Ser183Asn,,,,,saturation_mutlist,,,,,,,,0.02889,0.11525117635726928,,0.09770315391515533,,0.06329657695757766,,Neutral,Neutral,,Neutral,0.09578177408282598,,0.09140763652175822,0.4843,,-0.22866174600744396,,0.127819126996278,,Neutral,,Neutral,,0.1760751163519146,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,0.009,2.5172,-6.5298,-1.99451645324493,0.000104074367558,Benign,0.2328,benign,-3.212,available,https://doi.org/10.1101/2022.10.22.513328 +S183P,NP_000537:p.Ser183Pro,"hg19,17:g.7578383A>G, hg38,17:g.7675065A>G",,,0.457,"COSMIC,ClinVar,saturation_mutlist",3328150,Likely benign,1,,,,,0.51667,0.25390516996383666,2.58651,1.5213187193555362,1.55159,1.0189943596777682,Uncertain,Neutral,Neutral,Neutral,Neutral,0.2855396386482402,2.388617833364447,0.8275497263035828,2.31251,1.7168966666666667,2.961123160142659,2.0147033333333333,2.6368165800713292,Uncertain,Uncertain,Uncertain,Uncertain,0.5310181825093709,1.6365908299631435,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.1123,2.5172,-4.6038,-0.917250040714386,4.95141882247614e-07,Benign,0.1431,benign,-3.002,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S183Q,NP_000537:p.Ser183Gln,,,,,saturation_mutlist,,,,,,,,-0.20937,0.1558860445022583,,0.4009631278116228,,0.0957965639058114,,Neutral,Neutral,,Neutral,0.10269218832831332,,0.16120129149712606,0.69763,,0.07849256653599576,,0.3880612832679979,,Neutral,,Neutral,,0.2352163021409997,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.0174,2.5172,-7.8517,-1.99930412205824,0.0019536878296764,Benign,0.6339,pathogenic,-3.31,available,https://doi.org/10.1101/2022.10.22.513328 +S183R,NP_000537:p.Ser183Arg,,,,,saturation_mutlist,,,,,,,,-0.16005,0.20637815952301025,,0.0824772466051286,,-0.0387863766974357,,Neutral,Neutral,,Neutral,0.13240780074197186,,0.1343534265533548,0.93698,,-0.47674422457312055,,0.23011788771343974,,Neutral,,Neutral,,0.1672003732564126,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.038,2.5172,-1.7122,-1.57237522379816,0.0003056708184241,Benign,0.8145,pathogenic,-3.276,available,https://doi.org/10.1101/2022.10.22.513328 +S183T,NP_000537:p.Ser183Thr,,,,,saturation_mutlist,,,,,,,,0.12028,0.06797172307968138,,0.37334835753336765,,0.24681417876668382,,Neutral,Neutral,,Neutral,0.0931323175591283,,0.2630939234158095,0.5184,,0.2361327730968774,,0.3772663865484387,,Neutral,,Neutral,,0.21693055400805972,85.11,19.336,35.24,24.938,P,True,85.11,0.282,neutral,neutral,potentially_damaging,P,True,35.24,2.106,neutral,uncertain,potentially_damaging,uncertain,,0.0431,2.5172,-6.0444,-0.543773160589435,2.7714036358741894e-07,Benign,0.0928,benign,-3.048,available,https://doi.org/10.1101/2022.10.22.513328 +S183V,NP_000537:p.Ser183Val,,,,,saturation_mutlist,,,,,,,,0.29986,0.2618670320510864,,0.4301780053976369,,0.3650190026988185,,Neutral,Neutral,,Neutral,0.10004676457429071,,0.3072906697598297,0.84166,,-0.07057019120742543,,0.38554490439628725,,Neutral,,Neutral,,0.2233191412671056,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.0258,2.5172,-6.8517,-2.38764090355794,0.0005199387227,Benign,0.2396,benign,-3.285,available,https://doi.org/10.1101/2022.10.22.513328 +S183W,NP_000537:p.Ser183Trp,,,,,saturation_mutlist,,,,,,,,0.16958,0.2755177664756775,,-0.20544040375652958,,-0.017930201878264787,,Neutral,Neutral,,Neutral,0.08426692817288858,,0.24298930205129202,2.82305,,-0.805174718991938,,1.008937640504031,,Uncertain,,Neutral,,0.23971175646045756,85.11,19.336,35.24,24.938,P,True,85.11,0.282,damaging,neutral,potentially_damaging,P,True,35.24,2.106,damaging,uncertain,potentially_damaging,uncertain,,-0.1361,2.5172,-22.1395,-4.67543076910183,0.4994582358179026,Uncertain,0.5124,ambiguous,-3.941,available,https://doi.org/10.1101/2022.10.22.513328 +S183Y,NP_000537:p.Ser183Tyr,,,,,saturation_mutlist,,,,,,,,0.11615,0.3068088507652283,,0.10869687103691812,,0.11242343551845907,,Neutral,Neutral,,Neutral,0.13460828174221515,,0.1513264699655181,2.07294,,-0.31088386161209364,,0.8810280691939532,,Uncertain,,Neutral,,0.20959717535895278,85.11,19.336,35.24,24.938,P,True,85.11,0.282,uncertain,neutral,potentially_damaging,P,True,35.24,2.106,uncertain,uncertain,potentially_damaging,uncertain,,-0.1312,2.5172,-22.1395,-4.11716354669042,0.146856848063954,Benign,0.4008,ambiguous,-3.748,available,https://doi.org/10.1101/2022.10.22.513328 +D184A,NP_000537:p.Asp184Ala,,,,,saturation_mutlist,,,,,,,,0.31024,0.05193026542663571,2.2417233333333333,0.21198948303178108,1.2759816666666666,0.26111474151589054,Uncertain,Neutral,Neutral,Neutral,Neutral,0.0655102031877507,2.677157114855649,0.06725119172583081,0.23509,0.12426333333333332,0.638897754042132,0.17967666666666665,0.436993877021066,Neutral,Neutral,Neutral,Neutral,0.3599614066658937,0.3546000033013319,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.1843,1.7859,-22.2332,-4.13100823428518,0.0785305757985768,Benign,0.3377,benign,-3.544,available,https://doi.org/10.1101/2022.10.22.513328 +D184C,NP_000537:p.Asp184Cys,"hg19,17:g.7578379_7578380delinsCA",,,,"cBioPortal,saturation_mutlist",,,,,,,,0.33255,-0.18407855272293086,2.8265266666666666,0.809172048843931,1.5795383333333333,0.5708610244219655,Uncertain,Neutral,Neutral,Neutral,Neutral,0.08856922852935312,2.7658440729047293,0.08693145829314396,0.37067,0.7316333333333334,1.2897922951905165,0.5511516666666667,0.8302311475952583,Neutral,Neutral,Neutral,Neutral,0.19219324239478924,0.4665383697925318,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.158,1.7859,-8.9453,-4.35135669521169,0.0005981641593137,Benign,0.702,pathogenic,-3.644,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D184E,NP_000537:p.Asp184Glu,"hg19,17:g.7578378A>T, hg38,17:g.7675060A>T",,,0.558,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.14423,0.04644348382949826,1.1407033333333332,-0.14716844779001148,0.4982366666666666,-0.14569922389500573,Neutral,Neutral,Neutral,Neutral,Neutral,0.05790995575283319,1.4460491025395905,0.02043957227094758,-0.17181,0.43492,0.7924130901085018,0.13155499999999998,0.3103015450542509,Neutral,Neutral,Neutral,Neutral,0.14208686380755495,0.43116019489050966,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.0271,1.7859,-2.2175,-0.343448415506865,5.7841641899049986e-09,Benign,0.1615,benign,-2.859,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D184F,NP_000537:p.Asp184Phe,,,,,saturation_mutlist,,,,,,,,0.06358,0.018289484977722145,,-0.17830681993091768,,-0.05736340996545884,,Neutral,Neutral,,Neutral,0.13330652043349311,,0.11888680652630286,0.00292,,0.0749539377382286,,0.038936968869114304,,Neutral,,Neutral,,0.9441431967791564,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.2845,1.7859,-22.2332,-4.55387540351303,0.2385008318923899,Benign,0.7036,pathogenic,-3.956,available,https://doi.org/10.1101/2022.10.22.513328 +D184G,NP_000537:p.Asp184Gly,"hg19,17:g.7578379T>C, hg38,17:g.7675061T>C",,,0.666,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406606,Uncertain significance,1,,,,,0.40164,0.1983385968208313,2.8283466666666666,0.8468934622932678,1.6149933333333333,0.6242667311466339,Uncertain,Neutral,Neutral,Neutral,Neutral,0.09420089911930907,2.7911704044520262,0.05394709957629679,-0.23507,1.3225666666666667,1.3732116809244033,0.5437483333333333,0.5690708404622016,Neutral,Neutral,Neutral,Neutral,0.26170544948259844,0.467242625410686,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.1196,1.7859,-7.3604,-2.86758815566188,8.665341501275222e-05,Benign,0.2792,benign,-3.123,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D184H,NP_000537:p.Asp184His,"hg19,17:g.7578380C>G, hg19,17:g.7675062C>G, hg38,17:g.7675062C>G",,,0.700,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2687701,Uncertain significance,0,,,,,0.45453,-0.008523221015930189,1.6854866666666668,-0.22585946176507368,1.0700083333333335,0.11433526911746315,Neutral,Neutral,Neutral,Neutral,Neutral,0.1088434092766081,2.2833303098958084,0.054420717317499284,0.45829,0.28492,0.31290187590880697,0.37160499999999996,0.3855959379544035,Neutral,Neutral,Neutral,Neutral,0.23232532635652675,0.7890147196326106,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.1258,1.7859,-8.9453,-3.90031923608068,0.0051032790297124,Benign,0.5343,ambiguous,-3.458,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D184I,NP_000537:p.Asp184Ile,,,,,saturation_mutlist,,,,,,,,0.41458,0.05446618556976318,,-0.2801105259237964,,0.06723473703810179,,Neutral,Neutral,,Neutral,0.10980592514604674,,0.1519577569341249,0.80311,,0.7239105355789831,,0.7635102677894916,,Neutral,,Neutral,,0.7296331359367106,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.2767,1.7859,-22.2332,-4.15409404302754,0.1145243634211208,Benign,0.5842,pathogenic,-3.808,available,https://doi.org/10.1101/2022.10.22.513328 +D184K,NP_000537:p.Asp184Lys,,,,,saturation_mutlist,,,,,,,,0.11377,0.1875944423675537,,-0.0829695761090993,,0.015400211945450347,,Neutral,Neutral,,Neutral,0.07810558091693053,,0.07823724837168552,-0.06837,,0.9029192857485621,,0.417274642874281,,Neutral,,Neutral,,0.5140043802816371,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.2551,1.7859,-22.2332,-4.5543551955672,0.1081488927739461,Benign,0.6912,pathogenic,-3.56,available,https://doi.org/10.1101/2022.10.22.513328 +D184L,NP_000537:p.Asp184Leu,,,,,saturation_mutlist,,,,,,,,0.15979,0.03038044929504394,,-0.34498784961360435,,-0.09259892480680218,,Neutral,Neutral,,Neutral,0.06197625774681546,,0.11615542013632159,-0.20109,,-0.07622093614678964,,-0.13865546807339482,,Neutral,,Neutral,,0.7982409404071162,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.2703,1.7859,-22.2332,-3.12135022782395,0.0494995396543588,Benign,0.5756,pathogenic,-3.645,available,https://doi.org/10.1101/2022.10.22.513328 +D184M,NP_000537:p.Asp184Met,,,,,saturation_mutlist,,,,,,,,0.23037,0.11790863037109373,,-0.006667300768213101,,0.11185134961589345,,Neutral,Neutral,,Neutral,0.06817644945417344,,0.08796953881771323,-0.34548,,0.21645797657199162,,-0.0645110117140042,,Neutral,,Neutral,,0.6761589305884935,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.2091,1.7859,-22.2332,-3.16389501613802,0.1623383646307422,Benign,0.7759,pathogenic,-3.825,available,https://doi.org/10.1101/2022.10.22.513328 +D184N,NP_000537:p.Asp184Asn,"hg19,17:g.7578380C>T, hg38,17:g.7675062C>T",,,0.433,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.27568,0.07919522762298582,1.5891166666666665,0.026048995241659063,0.9323983333333332,0.1508644976208295,Neutral,Neutral,Neutral,Neutral,Neutral,0.05716307393127793,2.0193519364775314,0.1337076492163823,0.16514,-0.007143333333333353,0.5084729126129757,0.07899833333333332,0.33680645630648787,Neutral,Neutral,Neutral,Neutral,0.42102600999093737,0.466408011314688,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.0449,1.7859,-1.4456,-2.67346273286837,0.0014756214431764,Benign,0.1931,benign,-3.33,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D184P,NP_000537:p.Asp184Pro,,,,,saturation_mutlist,,,,,,,,0.78088,0.2817526376247406,,1.4898195676249386,,1.1353497838124693,,Neutral,Neutral,,Neutral,0.16964661792678895,,0.4591790690225512,1.07124,,4.584116027790412,,2.8276780138952056,,Uncertain,,Uncertain,,1.9687704882993293,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.3213,1.7859,-22.2332,-5.37161229502735,0.3924484246597846,Uncertain,0.7166,pathogenic,-3.616,available,https://doi.org/10.1101/2022.10.22.513328 +D184Q,NP_000537:p.Asp184Gln,,,,,saturation_mutlist,,,,,,,,0.10263,0.09239090919494627,,0.18173422265236713,,0.14218211132618358,,Neutral,Neutral,,Neutral,0.06124733382442176,,0.02206996288406621,0.07776,,0.8240455347896627,,0.45090276739483137,,Neutral,,Neutral,,0.5364683227868072,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.1435,1.7859,-8.9453,-2.55781556587848,0.0719210154757306,Benign,0.5513,ambiguous,-3.482,available,https://doi.org/10.1101/2022.10.22.513328 +D184R,NP_000537:p.Asp184Arg,,,,,saturation_mutlist,,,,,,,,0.18192,0.21956591486930846,,-0.1865915948072283,,-0.0023357974036141566,,Neutral,Neutral,,Neutral,0.08251073780201022,,0.11261512406043343,0.13931,,0.38469082455020637,,0.2620004122751032,,Neutral,,Neutral,,0.5965864912877763,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.2183,1.7859,-8.9453,-4.27329689644672,0.0142855921563028,Benign,0.6854,pathogenic,-3.514,available,https://doi.org/10.1101/2022.10.22.513328 +D184S,NP_000537:p.Asp184Ser,,,,,saturation_mutlist,,,,,,,,0.38276,0.038224954605102515,,0.1816462735387064,,0.2822031367693532,,Neutral,Neutral,,Neutral,0.056809481522052,,0.03025722557574619,0.47935,,0.952024954943219,,0.7156874774716095,,Neutral,,Neutral,,0.4059154740775272,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.1127,1.7859,-6.9454,-3.74160804452424,0.0363100307482636,Benign,0.2213,benign,-3.406,available,https://doi.org/10.1101/2022.10.22.513328 +D184T,NP_000537:p.Asp184Thr,,,,,saturation_mutlist,,,,,,,,0.39261,0.05974615335464477,,-0.020065437158074934,,0.18627228142096253,,Neutral,Neutral,,Neutral,0.10024111278938347,,0.10322061409948878,0.91776,,1.0314431067491552,,0.9746015533745775,,Neutral,,Neutral,,0.4173155322242095,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.153,1.7859,-8.9453,-3.90179158913291,0.0416324070219145,Benign,0.3938,ambiguous,-3.614,available,https://doi.org/10.1101/2022.10.22.513328 +D184V,NP_000537:p.Asp184Val,,,,,saturation_mutlist,,,,,,,,0.50453,0.09453762769699095,2.4206333333333334,-0.1571063156207575,1.4625816666666667,0.17371184218962127,Uncertain,Neutral,Neutral,Neutral,Neutral,0.10910000432871454,3.2250942600832957,0.13424011585620038,0.66512,-0.012243333333333337,0.8100625054198578,0.32643833333333333,0.7375912527099289,Neutral,Neutral,Neutral,Neutral,0.21928049105097233,0.5907217588002986,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.2314,1.7859,-22.2332,-3.10883732625192,0.0268363840903444,Benign,0.3933,ambiguous,-3.586,available,https://doi.org/10.1101/2022.10.22.513328 +D184W,NP_000537:p.Asp184Trp,,,,,saturation_mutlist,,,,,,,,0.29211,-0.029835445880889887,,-0.5064513955879882,,-0.10717069779399413,,Neutral,Neutral,,Neutral,0.1504511819241092,,0.052642766271006614,0.55641,,-0.29105269528198546,,0.13267865235900725,,Neutral,,Neutral,,0.9319902303706227,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.2649,1.7859,-22.2332,-4.55387540351303,0.5412330812257584,Uncertain,0.9257,pathogenic,-4.127,available,https://doi.org/10.1101/2022.10.22.513328 +D184Y,NP_000537:p.Asp184Tyr,"hg38,17:g.7675062C>A",,,0.715,"COSMIC,saturation_mutlist",,,,,,,,0.11313,0.030371162891387922,1.98367,-0.08877177024902556,1.0484,0.012179114875487215,Neutral,Neutral,Neutral,Neutral,Neutral,0.1646114396907952,3.12695812333115,0.0976733403950137,0.14576,-0.22653,0.19961075667055947,-0.040385000000000004,0.17268537833527975,Neutral,Neutral,Neutral,Neutral,0.25745899026187974,0.8685688768747796,86.489,7.794,58.725,22.554,,True,86.489,,neutral,neutral,neutral,,True,58.725,,neutral,neutral,neutral,uncertain,,-0.1513,1.7859,-6.9454,-1.812225626061,0.0548764689083884,Benign,0.451,ambiguous,-3.81,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185A,NP_000537:p.Ser185Ala,,,,,saturation_mutlist,,,,,,,,0.44878,0.19832315564155578,,0.08895543173898328,,0.26886771586949165,,Neutral,Neutral,,Neutral,0.1279608626448662,,0.14161851768653605,-0.22218,,0.337728067822134,,0.057774033911067,,Neutral,,Neutral,,0.25993998231297916,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,0.0073,2.3904,-8.9541,-1.62880461624935,5.112932982034425e-05,Benign,0.1073,benign,-3.111,available,https://doi.org/10.1101/2022.10.22.513328 +S185C,NP_000537:p.Ser185Cys,"hg38,17:g.7675059T>A",,,0.425,"COSMIC,saturation_mutlist",,,,,,,,0.34999,0.1937626314163208,0.6839,0.6826729780558013,0.516945,0.5163314890279007,Neutral,Neutral,Neutral,Neutral,Neutral,0.24286003856491833,0.3333166966514979,0.09756082986625506,0.15585,0.5574833333333333,0.7659343181066202,0.3566666666666667,0.46089215905331005,Neutral,Neutral,Neutral,Neutral,0.137113023046277,0.37039889785165764,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.111,2.3904,-22.2419,-3.51485496891826,0.1296969203286025,Benign,0.1144,benign,-3.638,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185D,NP_000537:p.Ser185Asp,,,,,saturation_mutlist,,,,,,,,1.53416,0.2347070622444153,,0.36013616071845017,,0.947148080359225,,Neutral,Neutral,,Neutral,0.1695896571438151,,0.28480303112688493,0.04195,,0.17123156226052424,,0.10659078113026213,,Neutral,,Neutral,,0.6837224132941045,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.0914,2.3904,-8.9541,-2.13912657237141,0.0005427836939308,Benign,0.3869,ambiguous,-3.354,available,https://doi.org/10.1101/2022.10.22.513328 +S185E,NP_000537:p.Ser185Glu,,,,,saturation_mutlist,,,,,,,,1.46453,0.5933081781864167,,0.4173935487367915,,0.9409617743683958,,Neutral,Neutral,,Neutral,0.23593965854069004,,0.2736568662810158,0.05326,,0.3458104200711572,,0.19953521003557861,,Neutral,,Neutral,,0.6867439390834034,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.0268,2.3904,-1.5448,-1.31715398243916,3.6905182346360975e-06,Benign,0.5751,pathogenic,-3.17,available,https://doi.org/10.1101/2022.10.22.513328 +S185F,NP_000537:p.Ser185Phe,,,,,saturation_mutlist,,,,,,,,0.84835,0.49744707584381104,,-0.18003628806747737,,0.3341568559662613,,Neutral,Neutral,,Neutral,0.4188603602114867,,0.36566726387631965,0.35821,,-0.422215969915346,,-0.03200298495767301,,Neutral,,Neutral,,0.2279128799900797,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.0433,2.3904,-3.5619,-3.22749031943694,0.0075187856799294,Benign,0.376,ambiguous,-3.392,available,https://doi.org/10.1101/2022.10.22.513328 +S185G,NP_000537:p.Ser185Gly,"hg38,17:g.7675059T>C",,,0.497,"COSMIC,saturation_mutlist",,,,,,,,1.03968,0.4506505584716797,1.4590699999999999,0.6934241335806561,1.249375,0.866552066790328,Neutral,Neutral,Neutral,Neutral,Neutral,0.12666743872681457,0.07582889466863321,0.15260782555720198,-0.82122,0.6538533333333333,0.6527262964900388,-0.08368333333333333,-0.08424685175498059,Neutral,Neutral,Neutral,Neutral,0.6564243461020892,0.8852061655925281,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,0.0231,2.3904,-4.0473,-0.766135825224233,6.980049260636952e-10,Benign,0.0635,benign,-2.834,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185H,NP_000537:p.Ser185His,,,,,saturation_mutlist,,,,,,,,1.47869,0.39900258779525755,,-0.1624645279317303,,0.6581127360341349,,Neutral,Neutral,,Neutral,0.3500360354250492,,0.2131291840726946,0.29833,,-0.3765475780383271,,-0.039108789019163565,,Neutral,,Neutral,,0.20211828338111193,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.1398,2.3904,-22.2419,-3.71634779464388,0.0047648113307593,Benign,0.3539,ambiguous,-3.344,available,https://doi.org/10.1101/2022.10.22.513328 +S185I,NP_000537:p.Ser185Ile,"hg38,17:g.7675058C>A",,,0.452,"COSMIC,saturation_mutlist",,,,,,,,1.10454,0.6988883948326111,1.80975,0.09084398890809653,1.4571450000000001,0.5976919944540483,Neutral,Neutral,Neutral,Neutral,Neutral,0.38170311796123196,1.688434391105164,0.3500819216474828,0.95922,1.39286,0.6823833310622883,1.17604,0.8208016655311441,Neutral,Neutral,Neutral,Neutral,2.2313843313960957,0.66731103793191,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.1417,2.3904,-22.2419,-1.77177164818091,0.0176949123262931,Benign,0.2053,benign,-3.308,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185K,NP_000537:p.Ser185Lys,,,,,saturation_mutlist,,,,,,,,0.58054,0.7228817641735077,,0.25949916922241584,,0.4200195846112079,,Neutral,Neutral,,Neutral,0.3783304415482889,,0.20549367176622016,0.1864,,0.019174811139262383,,0.1027874055696312,,Neutral,,Neutral,,0.5154857986493986,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.0695,2.3904,-6.6322,-1.60686075827579,3.7038293967409643e-07,Benign,0.7004,pathogenic,-3.178,available,https://doi.org/10.1101/2022.10.22.513328 +S185L,NP_000537:p.Ser185Leu,,,,,saturation_mutlist,,,,,,,,1.61555,0.6782327389717102,,-0.33289711485986084,,0.6413264425700695,,Neutral,Neutral,,Neutral,0.3979555275439429,,0.38317949617270064,0.30744,,-0.21113155719644316,,0.04815422140177841,,Neutral,,Neutral,,0.1808615476512471,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.138,2.3904,-22.2419,-4.41582752221782,0.0164444188381301,Benign,0.1892,benign,-3.445,available,https://doi.org/10.1101/2022.10.22.513328 +S185M,NP_000537:p.Ser185Met,,,,,saturation_mutlist,,,,,,,,0.12089,0.5897622394561768,,-0.0726480120749482,,0.0241209939625259,,Neutral,Neutral,,Neutral,0.32560016029760536,,0.36027406071570756,0.16195,,0.018123093698713174,,0.0900365468493566,,Neutral,,Neutral,,0.17031179113040898,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.0361,2.3904,-7.9541,-2.62492258047863,0.0007586823517706,Benign,0.2443,benign,-3.287,available,https://doi.org/10.1101/2022.10.22.513328 +S185N,NP_000537:p.Ser185Asn,"hg19,17:g.7578376C>T, hg38,17:g.7675058C>T",,3.9786743057e-06,0.325,"COSMIC,ClinVar,saturation_mutlist",141359,Likely benign,3,,,,,1.04212,0.3299357807636261,0.9230166666666667,-0.06368675956441067,0.9825683333333333,0.48921662021779466,Neutral,Neutral,Neutral,Neutral,Neutral,0.22385771623342793,0.18298688046475411,0.1964598201263153,0.00421,-0.30441999999999997,-0.20517593714681057,-0.150105,-0.10048296857340529,Neutral,Neutral,Neutral,Neutral,0.5033180891510524,0.44217407840831957,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,0.0213,2.3904,-1.8249,0.116493607243856,1.4102517015406523e-10,Benign,0.0957,benign,-2.803,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185P,NP_000537:p.Ser185Pro,,,,,saturation_mutlist,,,,,,,,1.61788,0.3430907225608826,,1.7085836687408065,,1.6632318343704031,,Neutral,Neutral,,Neutral,0.4212892464461901,,1.0098840691624968,1.9507,,3.9874916308201223,,2.969095815410061,,Uncertain,,Uncertain,,1.8755925892111098,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.1462,2.3904,-8.9541,-3.21676365750743,0.0031768670953529,Benign,0.3448,ambiguous,-3.322,available,https://doi.org/10.1101/2022.10.22.513328 +S185Q,NP_000537:p.Ser185Gln,,,,,saturation_mutlist,,,,,,,,1.25359,0.5189852130413055,,0.3116181299632922,,0.7826040649816461,,Neutral,Neutral,,Neutral,0.26871618209445863,,0.26833906963389165,0.14996,,0.23157232398553848,,0.19076616199276925,,Neutral,,Neutral,,0.3440279555636519,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.0347,2.3904,-8.9541,-1.56781595013197,0.0002662976257084,Benign,0.4911,ambiguous,-3.204,available,https://doi.org/10.1101/2022.10.22.513328 +S185R,NP_000537:p.Ser185Arg,"hg19,17:g.7578375G>C, hg38,17:g.7675057G>C, hg38,17:g.7675057G>T",,,0.520,"COSMIC,ClinVar,saturation_mutlist",1748280,Likely benign,1,,,,,0.83904,0.7228137373924255,0.5345799999999999,-0.09838786387028912,0.6868099999999999,0.37032606806485546,Neutral,Neutral,Neutral,Neutral,Neutral,0.3791662784328985,0.45520964027577443,0.2264125970678836,0.03379,0.13401333333333335,-0.250329526358401,0.08390166666666668,-0.1082697631792005,Neutral,Neutral,Neutral,Neutral,0.18335592751682603,0.3013998974455016,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.0785,2.3904,-7.3692,-2.1883691405826,0.0023156931656036,Benign,0.6104,pathogenic,-3.306,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185T,NP_000537:p.Ser185Thr,"hg38,17:g.7675057_7675058delinsCG",,,,"COSMIC,saturation_mutlist",,,,,,,,0.14471,0.315857367515564,0.24262999999999998,0.12688379201147995,0.19367,0.13579689600573996,Neutral,Neutral,Neutral,Neutral,Neutral,0.15443825194253025,0.2184257971638576,0.17954531512017424,0.60194,0.30657666666666666,0.5049445399601821,0.4542583333333333,0.553442269980091,Neutral,Neutral,Neutral,Neutral,0.48034878510885765,0.36178042276508565,44.34,14.201,73.26,32.473,P,True,44.34,3.325,neutral,damaging,potentially_damaging,P,True,73.26,0.814,neutral,neutral,potentially_damaging,uncertain,,0.0309,2.3904,-6.1468,-1.53198523946946,1.0979120339077929e-05,Benign,0.0858,benign,-3.06,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185V,NP_000537:p.Ser185Val,,,,,saturation_mutlist,,,,,,,,1.09169,0.6334453701972962,,0.10731717442937126,,0.5995035872146857,,Neutral,Neutral,,Neutral,0.31016081211847957,,0.22679339233136367,0.58695,,0.5350420053315798,,0.5609960026657899,,Neutral,,Neutral,,0.5001273180260065,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.0482,2.3904,-8.9541,-2.83257197794757,0.0028330619426754,Benign,0.2128,benign,-3.322,available,https://doi.org/10.1101/2022.10.22.513328 +S185W,NP_000537:p.Ser185Trp,,,,,saturation_mutlist,,,,,,,,1.73802,0.11271271467208863,,-0.5161660181015356,,0.6109269909492321,,Neutral,Neutral,,Neutral,0.2906609808163641,,0.2465004770504613,0.84382,,-0.6414620704140522,,0.10117896479297389,,Neutral,,Neutral,,0.10133244378220674,44.34,14.201,73.26,32.473,P,True,44.34,3.325,damaging,damaging,potentially_damaging,P,True,73.26,0.814,damaging,neutral,potentially_damaging,uncertain,,-0.1483,2.3904,-22.2419,-4.22792953630984,0.1951451222165565,Benign,0.5161,ambiguous,-3.774,available,https://doi.org/10.1101/2022.10.22.513328 +S185Y,NP_000537:p.Ser185Tyr,,,,,saturation_mutlist,,,,,,,,0.84375,0.39265318632125856,,-0.06637899580292628,,0.38868550209853686,,Neutral,Neutral,,Neutral,0.4314514801273379,,0.377948338181299,0.74346,,-0.3661818878140169,,0.18863905609299156,,Neutral,,Neutral,,0.19666794156822182,44.34,14.201,73.26,32.473,P,True,44.34,3.325,uncertain,damaging,potentially_damaging,P,True,73.26,0.814,uncertain,neutral,potentially_damaging,uncertain,,-0.0705,2.3904,-7.9541,-2.60875622288036,0.0314546800465435,Benign,0.3444,ambiguous,-3.388,available,https://doi.org/10.1101/2022.10.22.513328 +D186A,NP_000537:p.Asp186Ala,,,,,saturation_mutlist,,,,,,,,0.51815,0.26326847076416016,,0.6947340506052307,,0.6064420253026154,,Neutral,Neutral,,Neutral,0.21970366684426354,,0.620017351995929,0.34816,,0.2945016609899064,,0.3213308304949532,,Neutral,,Neutral,,0.2622336084747244,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.2046,1.5659,-22.239,-4.30897925100973,0.1067054553804836,Benign,0.6348,pathogenic,-3.593,available,https://doi.org/10.1101/2022.10.22.513328 +D186C,NP_000537:p.Asp186Cys,,,,,saturation_mutlist,,,,,,,,0.45914,0.10957541227340699,,1.4629202659082814,,0.9610301329541406,,Neutral,Neutral,,Neutral,0.1879747171982395,,0.5781132551597616,0.46644,,0.7894451169349302,,0.6279425584674652,,Neutral,,Neutral,,0.16955386484560694,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,uncertain,,-0.2461,1.5659,-22.239,-5.31085808942199,0.8118718569204268,Pathogenic,0.8978,pathogenic,-3.893,available,https://doi.org/10.1101/2022.10.22.513328 +D186E,NP_000537:p.Asp186Glu,"hg19,17:g.7578372A>T, hg38,17:g.7675054A>T",,3.9784843566e-06,0.643,"COSMIC,ClinVar,saturation_mutlist",230006,Likely benign,2,,,,,0.07479,0.25923039436340334,1.05941,0.4073800582781722,0.5670999999999999,0.24108502913908608,Neutral,Neutral,Neutral,Neutral,Neutral,0.19500195059881392,0.8177585882153731,0.5989019668951291,0.21769,0.40068,0.12508704444786528,0.309185,0.17138852222393264,Neutral,Neutral,Neutral,Neutral,0.47124466603524195,0.322251842219731,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.0604,1.5659,-4.7814,-0.647375049671803,2.796792722946493e-05,Benign,0.4078,ambiguous,-2.947,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D186F,NP_000537:p.Asp186Phe,,,,,saturation_mutlist,,,,,,,,0.39061,0.45196329593658446,,0.6681163466153861,,0.5293631733076931,,Neutral,Neutral,,Neutral,0.2533551835167106,,0.5962422108809131,0.3374,,-0.08660128168455183,,0.12539935915772407,,Neutral,,Neutral,,0.16076792751649877,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.3047,1.5659,-22.239,-5.48755082177828,0.8136444300467076,Pathogenic,0.9112,pathogenic,-4.068,available,https://doi.org/10.1101/2022.10.22.513328 +D186G,NP_000537:p.Asp186Gly,"hg38,17:g.7675055T>C",,,0.680,"COSMIC,saturation_mutlist",,,,,,,,0.52505,0.45283949613571167,3.0773233333333336,1.308339835812219,1.8011866666666667,0.9166949179061095,Uncertain,Neutral,Neutral,Neutral,Neutral,0.2041018535384608,1.996618244938732,0.6646355610888739,0.2288,1.2747166666666667,0.768142046140004,0.7517583333333333,0.498471023070002,Neutral,Neutral,Neutral,Neutral,0.4628046032854711,0.1938660111392873,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.1116,1.5659,-1.822,-5.69946724771392,0.7663948996261345,Pathogenic,0.5048,ambiguous,-3.684,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D186H,NP_000537:p.Asp186His,"hg38,17:g.7675056C>G",,,0.692,"COSMIC,saturation_mutlist",,,,,,,,0.61492,0.36454512357711794,2.217006666666667,0.34226899101816793,1.4159633333333335,0.47859449550908395,Uncertain,Neutral,Neutral,Neutral,Neutral,0.23256086051647015,1.738259151763306,0.6004648284516089,0.72528,0.19626000000000002,-0.22147758429893097,0.46077,0.25190120785053455,Neutral,Neutral,Neutral,Neutral,0.502351852854816,0.2051640328908561,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.2139,1.5659,-22.239,-3.91172505625663,0.0687013020967681,Benign,0.803,pathogenic,-3.53,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D186I,NP_000537:p.Asp186Ile,,,,,saturation_mutlist,,,,,,,,0.5905,0.5195196270942688,,0.7998567326324051,,0.6951783663162026,,Neutral,Neutral,,Neutral,0.2589060479838902,,0.6546813310558037,1.29919,,0.20563938195398423,,0.7524146909769922,,Neutral,,Neutral,,0.24369455323463504,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.297,1.5659,-22.239,-5.46714163006275,0.7399772064464887,Pathogenic,0.8904,pathogenic,-3.864,available,https://doi.org/10.1101/2022.10.22.513328 +D186K,NP_000537:p.Asp186Lys,,,,,saturation_mutlist,,,,,,,,0.36062,0.5100756859779358,,0.6834990580719124,,0.5220595290359562,,Neutral,Neutral,,Neutral,0.24515058387314545,,0.6267020777171901,0.16251,,0.10604828471748153,,0.13427914235874075,,Neutral,,Neutral,,0.22916523646561865,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.2753,1.5659,-22.239,-4.50583806841955,0.1293246949331405,Benign,0.8827,pathogenic,-3.657,available,https://doi.org/10.1101/2022.10.22.513328 +D186L,NP_000537:p.Asp186Leu,,,,,saturation_mutlist,,,,,,,,0.26658,0.38442044258117675,,0.3462660231497958,,0.30642301157489793,,Neutral,Neutral,,Neutral,0.2513116348710432,,0.568185992451285,0.29747,,-0.2799933562901818,,0.008738321854909109,,Neutral,,Neutral,,0.2870723654936507,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.2906,1.5659,-22.239,-5.25471483154328,0.5170391673677945,Uncertain,0.8285,pathogenic,-3.699,available,https://doi.org/10.1101/2022.10.22.513328 +D186M,NP_000537:p.Asp186Met,,,,,saturation_mutlist,,,,,,,,0.19979,0.481716251373291,,0.637828812526578,,0.418809406263289,,Neutral,Neutral,,Neutral,0.2418189642958916,,0.5695100887477532,0.04625,,0.013115090304903413,,0.029682545152451705,,Neutral,,Neutral,,0.32355406732578373,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.2294,1.5659,-22.239,-5.75187386230467,0.8705122248767049,Pathogenic,0.9369,pathogenic,-4.086,available,https://doi.org/10.1101/2022.10.22.513328 +D186N,NP_000537:p.Asp186Asn,"hg19,17:g.7578374C>T, hg38,17:g.7675056C>T",,7.957728546e-06,0.532,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406601,Likely benign,3,,,,,0.39003,0.21071183919906614,1.8261900000000002,0.4647122105475034,1.1081100000000002,0.42737110527375166,Neutral,Neutral,Neutral,Neutral,Neutral,0.11942344024101673,1.6688479046535865,0.4524173794553166,0.32195,-0.059186666666666644,-0.1185169993618775,0.13138166666666667,0.10171650031906126,Neutral,Neutral,Neutral,Neutral,0.41698394807900646,0.18904187075489995,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,uncertain,,-0.0732,1.5659,-3.0206,-1.78942865852632,0.0576889928369687,Benign,0.3448,ambiguous,-3.262,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D186P,NP_000537:p.Asp186Pro,,,,,saturation_mutlist,,,,,,,,0.26775,0.25927349090576174,,2.219922375775578,,1.243836187887789,,Uncertain,Neutral,,Neutral,0.2970603235515073,,0.7013583803752319,2.64285,,3.6656160836389358,,3.154233041819468,,Uncertain,,Destabilizing,,0.46402431041218606,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,uncertain,,-0.3416,1.5659,-22.239,-5.08249865396284,0.4575278139407727,Uncertain,0.8725,pathogenic,-3.635,available,https://doi.org/10.1101/2022.10.22.513328 +D186Q,NP_000537:p.Asp186Gln,,,,,saturation_mutlist,,,,,,,,0.3755,0.43057225227355955,,0.7393790289125822,,0.5574395144562911,,Neutral,Neutral,,Neutral,0.22807510719852256,,0.5127275904971739,0.29854,,0.28155594802961775,,0.29004797401480886,,Neutral,,Neutral,,0.30555214550658,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.2316,1.5659,-22.239,-3.05957110403163,0.3526359081521077,Uncertain,0.8221,pathogenic,-3.497,available,https://doi.org/10.1101/2022.10.22.513328 +D186R,NP_000537:p.Asp186Arg,,,,,saturation_mutlist,,,,,,,,0.47219,0.5455892038345337,,0.6287892200608814,,0.5504896100304407,,Neutral,Neutral,,Neutral,0.2351044841643125,,0.6003706378367661,0.39458,,-0.11427399924704428,,0.14015300037647785,,Neutral,,Neutral,,0.17233616075651623,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.3063,1.5659,-22.239,-3.45618973141325,0.0322971714307329,Benign,0.8559,pathogenic,-3.564,available,https://doi.org/10.1101/2022.10.22.513328 +D186S,NP_000537:p.Asp186Ser,,,,,saturation_mutlist,,,,,,,,0.51622,0.22104252815246578,,0.564047779599521,,0.5401338897997605,,Neutral,Neutral,,Neutral,0.11381527592945649,,0.5996017554318568,0.42188,,0.40256671037112285,,0.4122233551855614,,Neutral,,Neutral,,0.18664748796661645,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.1381,1.5659,-7.9512,-3.5823531868822,0.0572049065537213,Benign,0.4325,ambiguous,-3.446,available,https://doi.org/10.1101/2022.10.22.513328 +D186T,NP_000537:p.Asp186Thr,,,,,saturation_mutlist,,,,,,,,0.65195,0.370274977684021,,0.7475744770757772,,0.6997622385378885,,Neutral,Neutral,,Neutral,0.17584555215735465,,0.5938417280222399,1.01509,,0.36993969474535054,,0.6925148473726753,,Neutral,,Neutral,,0.21888778018372063,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,uncertain,,-0.241,1.5659,-22.239,-4.44569198926029,0.6668990342487736,Uncertain,0.659,pathogenic,-3.614,available,https://doi.org/10.1101/2022.10.22.513328 +D186V,NP_000537:p.Asp186Val,"hg38,17:g.7675055T>A",,,0.800,"COSMIC,saturation_mutlist",,,,,,,,0.7075,0.5450811648368835,2.7366233333333336,0.7184261000392529,1.7220616666666668,0.7129630500196265,Uncertain,Neutral,Neutral,Neutral,Neutral,0.28345012773593314,1.934178851646237,0.5647177997091736,1.22599,0.45147333333333334,0.23420752463153902,0.8387316666666667,0.7300987623157694,Neutral,Neutral,Neutral,Neutral,0.8775760647500718,0.20179123224087944,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.2517,1.5659,-22.239,-5.75187386230467,0.7577473521752536,Pathogenic,0.7499,pathogenic,-3.76,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D186W,NP_000537:p.Asp186Trp,,,,,saturation_mutlist,,,,,,,,0.43171,0.4385539722442627,,0.240015344824,,0.33586267241199996,,Neutral,Neutral,,Neutral,0.2286114830775488,,0.5641405911404027,0.99592,,-0.36463839607912885,,0.3156408019604356,,Neutral,,Neutral,,0.2343223707655778,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.2852,1.5659,-22.239,-5.48755082177828,0.8608548765921111,Pathogenic,0.9714,pathogenic,-4.302,available,https://doi.org/10.1101/2022.10.22.513328 +D186Y,NP_000537:p.Asp186Tyr,,,,,saturation_mutlist,,,,,,,,0.4177,0.5243215322494507,2.38197,0.6932710037110065,1.399835,0.5554855018555033,Uncertain,Neutral,Neutral,Neutral,Neutral,0.2794158966688215,2.037023739691481,0.5395099537890488,0.39366,0.30476333333333333,0.004246091393550301,0.3492116666666667,0.19895304569677516,Neutral,Neutral,Neutral,Neutral,0.15298472959380255,0.1297153270150877,84.35,13.986,53.435,23.888,,True,84.35,,neutral,neutral,neutral,,True,53.435,,neutral,neutral,neutral,damaging,,-0.2496,1.5659,-22.239,-5.48755082177828,0.8507373884401419,Pathogenic,0.7262,pathogenic,-4.159,available,https://doi.org/10.1101/2022.10.22.513328 +G187A,NP_000537:p.Gly187Ala,"hg19,17:g.7578289C>G, hg38,17:g.7674971C>G",,,0.610,"ClinVar,saturation_mutlist",1479275,Uncertain significance,2,,,,,1.51195,0.66107262134552,1.18594,1.1149725951953622,1.348945,1.313461297597681,Neutral,Neutral,Neutral,Neutral,Neutral,0.20280866988274626,0.8537445576986129,0.9332829779828823,2.05337,1.74603,1.0760513040897601,1.8997000000000002,1.5647106520448801,Uncertain,Uncertain,Neutral,Neutral,1.7597150162455282,0.8285782355834919,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.1286,1.8092,-4.8667,-1.7231937485443,6.24067825606827e-05,Benign,0.2047,benign,-3.14,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G187C,NP_000537:p.Gly187Cys,"hg19,17:g.7578371C>A, hg19,17:g.7675053C>A, hg38,17:g.7675053C>A",,,0.705,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.04533,0.46691415548324583,1.4209733333333334,1.4536471809286364,1.7331516666666666,1.7494885904643183,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.16116645530401194,1.2043910078634026,0.7323535743814593,2.40676,2.4812933333333334,1.802139221182843,2.444026666666667,2.1044496105914217,Uncertain,Uncertain,Uncertain,Uncertain,1.7540155021423145,0.7939545547918971,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.2011,1.8092,-7.3692,-2.23517995208198,0.0178272437190742,Benign,0.2974,benign,-3.536,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G187D,NP_000537:p.Gly187Asp,"hg19,17:g.7578289C>T, hg38,17:g.7674971C>T",,,0.625,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",422532,Uncertain significance,2,,,,,1.19759,0.6137686753273011,1.1634933333333333,0.8034536637607892,1.1805416666666666,1.0005218318803946,Neutral,Neutral,Neutral,Neutral,Neutral,0.25587440674689854,1.6356465850000181,0.5149629097466365,2.54481,2.19796,1.033068775572829,2.371385,1.7889393877864146,Uncertain,Uncertain,Uncertain,Neutral,2.204887643456389,1.023368830997163,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.1935,1.8092,-5.7843,-2.47844934009982,2.268585438648931e-07,Benign,0.4916,ambiguous,-3.198,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G187E,NP_000537:p.Gly187Glu,,,,,saturation_mutlist,,,,,,,,2.17308,0.9838860154151916,,1.2418528161662568,,1.7074664080831283,,Uncertain,Neutral,,Neutral,0.3073381066876914,,0.8162425375612966,2.63824,,1.3554206497965582,,1.996830324898279,,Uncertain,,Neutral,,1.3890164100274776,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.2009,1.8092,-7.3692,-3.0470884145673,0.0079618195335704,Benign,0.5275,ambiguous,-3.358,available,https://doi.org/10.1101/2022.10.22.513328 +G187F,NP_000537:p.Gly187Phe,,,,,saturation_mutlist,,,,,,,,2.04794,1.004362576007843,,0.6178084803400831,,1.3328742401700415,,Uncertain,Uncertain,,Neutral,0.291379960252242,,0.8472444778270435,2.3146,,0.6839184964558802,,1.49925924822794,,Uncertain,,Neutral,,1.0496314969510587,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.3151,1.8092,-22.2419,-5.57393330133001,0.538141978151259,Uncertain,0.6951,pathogenic,-4.022,available,https://doi.org/10.1101/2022.10.22.513328 +G187H,NP_000537:p.Gly187His,,,,,saturation_mutlist,,,,,,,,2.35356,0.861828019618988,,0.5516652239072376,,1.4526126119536187,,Uncertain,Neutral,,Neutral,0.2283858137494967,,0.734656612767031,2.92946,,0.5943345141956704,,1.7618972570978353,,Uncertain,,Neutral,,0.9106273860128218,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.2898,1.8092,-22.2419,-4.72958727003029,0.1985824591031813,Benign,0.627,pathogenic,-3.625,available,https://doi.org/10.1101/2022.10.22.513328 +G187I,NP_000537:p.Gly187Ile,,,,,saturation_mutlist,,,,,,,,3.50823,1.3689043807983399,,1.909423028797261,,2.7088265143986305,,Uncertain,Uncertain,,Uncertain,0.37381725167284213,,1.2440394040149554,3.41767,,1.828142944357536,,2.622906472178768,,Uncertain,,Uncertain,,1.627991996502616,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.3607,1.8092,-22.2419,-5.2907994651809,0.338428186929777,Uncertain,0.4464,ambiguous,-3.958,available,https://doi.org/10.1101/2022.10.22.513328 +G187K,NP_000537:p.Gly187Lys,,,,,saturation_mutlist,,,,,,,,1.82698,1.1919203352928163,,1.023597010742433,,1.4252885053712165,,Neutral,Uncertain,,Neutral,0.3659032434634789,,0.8672342089314685,2.29603,,1.107465454928946,,1.701747727464473,,Uncertain,,Neutral,,1.224239614283686,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.3097,1.8092,-22.2419,-4.47806056422347,0.0273552140375972,Benign,0.8056,pathogenic,-3.623,available,https://doi.org/10.1101/2022.10.22.513328 +G187L,NP_000537:p.Gly187Leu,,,,,saturation_mutlist,,,,,,,,1.90035,1.3461558794975281,,0.7655993871582621,,1.3329746935791311,,Neutral,Uncertain,,Neutral,0.4604846155137756,,0.9413965570443139,2.50019,,0.6209797072666162,,1.560584853633308,,Uncertain,,Neutral,,1.0398021735224248,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.2612,1.8092,-8.9541,-3.66741501508662,0.08723123090266,Benign,0.5779,pathogenic,-3.682,available,https://doi.org/10.1101/2022.10.22.513328 +G187M,NP_000537:p.Gly187Met,,,,,saturation_mutlist,,,,,,,,1.5803,1.0859767031669616,,0.9147571619893675,,1.2475285809946839,,Neutral,Uncertain,,Neutral,0.32699821851429595,,0.9222410729393874,2.26548,,0.860753456998419,,1.5631167284992096,,Uncertain,,Neutral,,0.9306879116391253,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.1994,1.8092,-8.9541,-3.76120818651042,0.1917569780868795,Benign,0.6439,pathogenic,-3.826,available,https://doi.org/10.1101/2022.10.22.513328 +G187N,NP_000537:p.Gly187Asn,,,,,saturation_mutlist,,,,,,,,1.55534,0.6804030823707581,,0.5508460294266458,,1.0530930147133228,,Neutral,Neutral,,Neutral,0.18327311522658848,,0.7024740908375412,2.38871,,0.7396542284724205,,1.5641821142362102,,Uncertain,,Neutral,,0.6855670707231271,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.1957,1.8092,-6.1468,-2.59666971362815,0.0048306567758203,Benign,0.3905,ambiguous,-3.415,available,https://doi.org/10.1101/2022.10.22.513328 +G187P,NP_000537:p.Gly187Pro,,,,,saturation_mutlist,,,,,,,,3.44522,1.4092980003356934,,5.941838046134795,,4.693529023067398,,Destabilizing,Uncertain,,Destabilizing,0.327496075010813,,1.0820882086528623,4.94928,,5.075175664475366,,5.0122278322376825,,Destabilizing,,Destabilizing,,2.5743726234939492,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.3071,1.8092,-8.9541,-3.96536114774247,0.0206818584737298,Benign,0.8414,pathogenic,-3.648,available,https://doi.org/10.1101/2022.10.22.513328 +G187Q,NP_000537:p.Gly187Gln,,,,,saturation_mutlist,,,,,,,,1.99032,1.049795582294464,,1.2125449900791545,,1.6014324950395773,,Neutral,Uncertain,,Neutral,0.296722920408764,,0.8550640531304122,2.48361,,1.3534631959310293,,1.9185365979655147,,Uncertain,,Neutral,,1.0990978714020958,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.1746,1.8092,-1.4464,-3.84952316833349,0.0508804604056052,Benign,0.6098,pathogenic,-3.574,available,https://doi.org/10.1101/2022.10.22.513328 +G187R,NP_000537:p.Gly187Arg,"hg19,17:g.7578371C>G, hg19,17:g.7675053C>G, hg38,17:g.7675053C>G",,,0.700,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",635392,Conflicting classifications of pathogenicity,1,,,,,2.3941,1.1280981802940369,2.697843333333333,0.8034552596722705,2.5459716666666665,1.5987776298361351,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.3243171205308283,2.5968816287531387,0.9648881280908717,2.36441,1.82721,0.7438116352225789,2.09581,1.5541108176112894,Uncertain,Uncertain,Uncertain,Neutral,2.4451053298784493,1.005423066444265,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.2938,1.8092,-22.2419,-5.04099022305313,0.3075091274997505,Benign,0.6489,pathogenic,-3.662,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G187S,NP_000537:p.Gly187Ser,"hg19,17:g.7578371C>T, hg19,17:g.7675053C>T, hg38,17:g.7675053C>T",,,0.649,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",840399,Conflicting classifications of pathogenicity,1,,,Tier II - Potential,1,1.34138,0.5933551216125488,1.1600899999999998,1.1081993392649443,1.250735,1.224789669632472,Neutral,Neutral,Neutral,Neutral,Neutral,0.23359383599754685,1.0172722775474945,0.693281214944737,2.42654,1.15261,1.2274934270262847,1.7895750000000001,1.8270167135131423,Uncertain,Uncertain,Neutral,Neutral,1.5897882623796165,0.9532952592804894,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.1359,1.8092,-5.1468,-2.60475214338246,0.0001467881703475,Benign,0.1262,benign,-3.23,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G187T,NP_000537:p.Gly187Thr,,,,,saturation_mutlist,,,,,,,,3.00036,0.7924707198143005,,1.6221501193668626,,2.3112550596834316,,Uncertain,Neutral,,Uncertain,0.26442962333240194,,1.050066335779758,3.27856,,1.720207622937366,,2.4993838114686833,,Uncertain,,Uncertain,,1.327809492520626,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.2179,1.8092,-6.1468,-2.86096275188464,0.0101284754094703,Benign,0.2514,benign,-3.462,available,https://doi.org/10.1101/2022.10.22.513328 +G187V,NP_000537:p.Gly187Val,"hg19,17:g.7578289C>A, hg19,17:g.7674971C>A, hg38,17:g.7674971C>A, hg38,17:g.7674972del",,,0.666,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2032550,Uncertain significance,1,,,,,3.35889,1.2766177344322205,2.70839,1.6950900740634778,3.03364,2.526990037031739,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.33104542795324277,2.29030097499579,1.2182786595811796,3.51954,3.5513600000000003,1.7547528765067109,3.53545,2.6371464382533554,Destabilizing,Uncertain,Destabilizing,Uncertain,3.552734945446958,1.420003005779992,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.2281,1.8092,-7.3692,-3.18355446101431,0.0138205652241666,Benign,0.3175,benign,-3.549,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G187W,NP_000537:p.Gly187Trp,,,,,saturation_mutlist,,,,,,,,2.59929,0.9358730483055114,,0.48565646420660674,,1.5424732321033032,,Uncertain,Neutral,,Neutral,0.2765616276339779,,0.9803088659385076,2.62331,,0.3480767556355448,,1.4856933778177723,,Uncertain,,Neutral,,1.2186563174869007,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.3148,1.8092,-22.2419,-5.57393330133001,0.5533694911349891,Uncertain,0.6932,pathogenic,-4.192,available,https://doi.org/10.1101/2022.10.22.513328 +G187Y,NP_000537:p.Gly187Tyr,,,,,saturation_mutlist,,,,,,,,2.33148,0.9656296467781067,,0.8502906524774666,,1.5908853262387332,,Uncertain,Neutral,,Neutral,0.2845207161671523,,0.850823246200271,2.43248,,0.786462952933323,,1.6094714764666616,,Uncertain,,Neutral,,1.1303794063099615,56.367,18.283,109.675,27.215,,True,56.367,,neutral,neutral,neutral,,True,109.675,,neutral,neutral,neutral,uncertain,,-0.3154,1.8092,-22.2419,-5.57393330133001,0.4024047053152033,Uncertain,0.6616,pathogenic,-3.899,available,https://doi.org/10.1101/2022.10.22.513328 +L188A,NP_000537:p.Leu188Ala,,,,,saturation_mutlist,,,,,,,,0.64684,0.01951513528823854,,1.2167267207662362,,0.931783360383118,,Neutral,Neutral,,Neutral,0.1690696311664286,,0.7124975129429325,0.29653,,1.8531912102463297,,1.0748606051231648,,Neutral,,Neutral,,0.8030045129108072,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.0949,2.5085,-3.8667,-1.88041290835708,0.0001031998719289,Benign,0.2332,benign,-3.133,available,https://doi.org/10.1101/2022.10.22.513328 +L188C,NP_000537:p.Leu188Cys,,,,,saturation_mutlist,,,,,,,,0.75744,-0.07581145763397217,,1.6814279324788872,,1.2194339662394436,,Neutral,Neutral,,Neutral,0.11949335225305288,,0.5980321260591328,0.61213,,2.003673741614703,,1.3079018708073515,,Uncertain,,Neutral,,0.6523830054139758,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.1779,2.5085,-22.2419,-3.76520430130737,0.183021669992604,Benign,0.5863,pathogenic,-3.891,available,https://doi.org/10.1101/2022.10.22.513328 +L188D,NP_000537:p.Leu188Asp,,,,,saturation_mutlist,,,,,,,,0.32009,0.06608247756958008,,1.310939239721086,,0.815514619860543,,Neutral,Neutral,,Neutral,0.18597673860909206,,1.0483975291346201,0.66769,,2.3018695327660166,,1.4847797663830082,,Uncertain,,Neutral,,1.2289558799229343,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.3102,2.5085,-22.2419,-3.88352603194585,0.1801055762532335,Benign,0.6577,pathogenic,-3.684,available,https://doi.org/10.1101/2022.10.22.513328 +L188E,NP_000537:p.Leu188Glu,,,,,saturation_mutlist,,,,,,,,0.23512,0.2507084929943085,,1.208820984400301,,0.7219704922001505,,Neutral,Neutral,,Neutral,0.1749684319680825,,1.0876649255428477,0.88822,,2.1242718517623644,,1.5062459258811822,,Uncertain,,Neutral,,1.186033632295571,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.2783,2.5085,-22.2419,-3.06959987779917,0.0155423694041354,Benign,0.4127,ambiguous,-3.47,available,https://doi.org/10.1101/2022.10.22.513328 +L188F,NP_000537:p.Leu188Phe,,,,,saturation_mutlist,,,,,,,,0.19909,0.08451967716217039,,0.2916519337185406,,0.2453709668592703,,Neutral,Neutral,,Neutral,0.13401814608719698,,0.07845808932576011,1.45679,,1.4257340300491237,,1.4412620150245619,,Neutral,,Neutral,,1.0149150563271465,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,neutral,,-0.0544,2.5085,-8.9541,-3.85313818661833,0.0025842669878029,Benign,0.2063,benign,-3.392,available,https://doi.org/10.1101/2022.10.22.513328 +L188G,NP_000537:p.Leu188Gly,,,,,saturation_mutlist,,,,,,,,0.84299,0.2624826204776764,,1.840313483504147,,1.3416517417520735,,Neutral,Neutral,,Neutral,0.24010511436498888,,0.8580817596389079,0.51597,,3.0304567464416188,,1.7732133732208095,,Uncertain,,Neutral,,1.2962982954064959,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.1957,2.5085,-8.9541,-4.80408334732493,0.1419804086848305,Benign,0.5033,ambiguous,-3.542,available,https://doi.org/10.1101/2022.10.22.513328 +L188H,NP_000537:p.Leu188His,,,,,saturation_mutlist,,,,,,,,0.61691,0.04156518220901488,,0.5600757192518591,,0.5884928596259296,,Neutral,Neutral,,Neutral,0.124591444642188,,0.4614275791603475,1.34216,,1.6846672755978886,,1.5134136377989442,,Neutral,,Neutral,,0.950718895190044,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.2311,2.5085,-22.2419,-3.35316717660366,0.0291104950210152,Benign,0.2979,benign,-3.45,available,https://doi.org/10.1101/2022.10.22.513328 +L188I,NP_000537:p.Leu188Ile,,,,,saturation_mutlist,,,,,,,,0.35302,-0.02730067491531371,,0.5276625912007269,,0.44034129560036345,,Neutral,Neutral,,Neutral,0.08170644238860383,,0.4286149321079595,0.90217,,1.1255490726867468,,1.0138595363433733,,Neutral,,Neutral,,0.47837597976612384,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,0.0439,2.5085,-1.3321,-2.11522420262571,0.0120451884270478,Benign,0.1269,benign,-3.189,available,https://doi.org/10.1101/2022.10.22.513328 +L188K,NP_000537:p.Leu188Lys,,,,,saturation_mutlist,,,,,,,,0.19686,0.027678091526031495,,0.9283684876375053,,0.5626142438187527,,Neutral,Neutral,,Neutral,0.20288740560343194,,0.7612724759120979,0.69955,,2.579308428224731,,1.6394292141123654,,Uncertain,,Neutral,,1.6931884336668572,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.2095,2.5085,-8.9541,-3.64485453337967,0.0400993514253363,Benign,0.3779,ambiguous,-3.474,available,https://doi.org/10.1101/2022.10.22.513328 +L188M,NP_000537:p.Leu188Met,"hg38,17:g.7674969G>T",,,0.473,"COSMIC,saturation_mutlist",,,,,,,,0.2043,0.11145631551742553,1.3454633333333332,0.6169589160279765,0.7748816666666666,0.41062945801398826,Neutral,Neutral,Neutral,Neutral,Neutral,0.10384095295637384,0.18505291897784867,0.3701674875488453,-0.05956,1.32528,1.2671747131527598,0.63286,0.6038073565763799,Neutral,Neutral,Neutral,Neutral,0.4927704788912041,0.5016646954201798,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.004,2.5085,-6.1468,-2.03246337702532,0.0179310171339625,Benign,0.1544,benign,-3.266,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L188N,NP_000537:p.Leu188Asn,,,,,saturation_mutlist,,,,,,,,0.6839,0.044838697910308846,,1.0298957372826603,,0.8568978686413301,,Neutral,Neutral,,Neutral,0.15152087103657355,,0.7614153563037975,0.49743,,1.7357451135547628,,1.1165875567773813,,Neutral,,Neutral,,0.7126922671668335,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.1836,2.5085,-7.9541,-2.69445479080042,0.0057044195774277,Benign,0.3632,ambiguous,-3.415,available,https://doi.org/10.1101/2022.10.22.513328 +L188P,NP_000537:p.Leu188Pro,"hg19,17:g.7578286A>G, hg38,17:g.7674968A>G",,,0.617,"ClinVar,saturation_mutlist",4189268,Uncertain significance,1,,,,,0.64867,0.17143792748451234,3.11882,3.0314928284803337,1.883745,1.840081414240167,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.33604169726677424,2.066143932756541,0.658200121245837,0.66335,5.177436666666666,4.677656953078794,2.920393333333333,2.6705034765393973,Uncertain,Uncertain,Uncertain,Uncertain,2.0382726896457095,2.05389060707253,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.1839,2.5085,-4.9542,-2.07287529396529,9.920129325962272e-07,Benign,0.1339,benign,-3.047,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L188Q,NP_000537:p.Leu188Gln,"hg19,17:g.7578286A>T, hg38,17:g.7674968A>T",,,0.581,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.39753,0.09782953262329101,1.4480700000000002,1.146583697791612,0.9228000000000001,0.772056848895806,Neutral,Neutral,Neutral,Neutral,Neutral,0.16538371541792862,0.22744774887139826,0.83945706063082,0.78134,0.9782299999999999,1.7270555449370264,0.879785,1.2541977724685132,Neutral,Neutral,Neutral,Neutral,0.7486076436959482,0.6570006025961307,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.1204,2.5085,-4.7843,-4.02237159951265,0.1326427980461458,Benign,0.1893,benign,-3.521,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L188R,NP_000537:p.Leu188Arg,,,,,saturation_mutlist,,,,,,,,0.26062,0.05787497043609617,,0.6472238127745301,,0.45392190638726504,,Neutral,Neutral,,Neutral,0.22994218013431203,,0.6486739304230777,1.38886,,2.129340630151398,,1.759100315075699,,Uncertain,,Neutral,,1.427441605727146,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,neutral,,-0.193,2.5085,-7.3692,-2.17875171420542,0.0628984413568821,Benign,0.2609,benign,-3.514,available,https://doi.org/10.1101/2022.10.22.513328 +L188S,NP_000537:p.Leu188Ser,,,,,saturation_mutlist,,,,,,,,0.71289,-0.07872242927551269,,1.2861047090173237,,0.9994973545086618,,Neutral,Neutral,,Neutral,0.2150121817821116,,0.8776386255744061,0.94157,,2.3478844033329103,,1.6447272016664551,,Uncertain,,Neutral,,1.1023776939752516,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.1228,2.5085,-3.3692,-1.80905429493487,6.01470442142463e-05,Benign,0.2905,benign,-3.173,available,https://doi.org/10.1101/2022.10.22.513328 +L188T,NP_000537:p.Leu188Thr,,,,,saturation_mutlist,,,,,,,,0.68551,-0.04318527698516844,,1.1034884151921263,,0.8944992075960632,,Neutral,Neutral,,Neutral,0.21080090482276634,,0.7724531447492562,1.30623,,1.8512945811456152,,1.5787622905728076,,Neutral,,Neutral,,0.7759441765715128,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.1122,2.5085,-6.6322,-1.91715341693648,0.0002229552270836,Benign,0.2467,benign,-3.167,available,https://doi.org/10.1101/2022.10.22.513328 +L188V,NP_000537:p.Leu188Val,"hg19,17:g.7578287G>C, hg38,17:g.7674969G>C",,,0.572,"COSMIC,ClinVar,saturation_mutlist",933702,Uncertain significance,1,,,,,0.57748,0.10455204606056212,1.15839,0.663956435431018,0.867935,0.6207182177155091,Neutral,Neutral,Neutral,Neutral,Neutral,0.07335962400551425,0.42002580309627,0.4523107031542012,0.78909,0.9473933333333333,1.2730932848512093,0.8682416666666666,1.0310916424256047,Neutral,Neutral,Neutral,Neutral,0.41772279519104805,0.5541107894893516,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,uncertain,,-0.0053,2.5085,-3.8667,-1.55449930492216,6.715738354807394e-06,Benign,0.1186,benign,-3.056,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L188W,NP_000537:p.Leu188Trp,,,,,saturation_mutlist,,,,,,,,0.57171,0.05736483573913573,,0.12575915018832426,,0.34873457509416217,,Neutral,Neutral,,Neutral,0.20189926515803572,,0.2587525117290646,3.75338,,1.8260813042436401,,2.78973065212182,,Uncertain,,Uncertain,,1.6540970759261961,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,neutral,,-0.2213,2.5085,-22.2419,-4.37635006954498,0.5545923119647456,Uncertain,0.3995,ambiguous,-4.048,available,https://doi.org/10.1101/2022.10.22.513328 +L188Y,NP_000537:p.Leu188Tyr,,,,,saturation_mutlist,,,,,,,,0.25506,0.06507481813430784,,0.44382138468541105,,0.34944069234270553,,Neutral,Neutral,,Neutral,0.15119656148807725,,0.1918313890961844,2.72909,,1.8778474149811928,,2.3034687074905964,,Uncertain,,Uncertain,,1.3844513302738213,74.43,14.759,38.72,22.565,,True,74.43,,neutral,neutral,neutral,,True,38.72,,neutral,neutral,neutral,neutral,,-0.2142,2.5085,-22.2419,-4.0093896326611,0.0828497298309643,Benign,0.5037,ambiguous,-3.61,available,https://doi.org/10.1101/2022.10.22.513328 +A189C,NP_000537:p.Ala189Cys,,,,,saturation_mutlist,,,,,,,,0.854,0.43234006404876707,,1.1411362095367494,,0.9975681047683747,,Neutral,Neutral,,Neutral,0.22136649464759972,,0.14104389322705874,0.55075,,0.908219221714558,,0.729484610857279,,Neutral,,Neutral,,0.1540529610752511,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.2711,0.7558,-22.2419,-3.86452100200476,0.7140128768112822,Pathogenic,0.7797,pathogenic,-3.894,available,https://doi.org/10.1101/2022.10.22.513328 +A189D,NP_000537:p.Ala189Asp,"hg19,17:g.7578283G>T, hg38,17:g.7674965G>T",,,0.817,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2137906,Uncertain significance,1,,,,,2.00456,1.4519320297241212,3.804873333333333,2.1517970436697933,2.9047166666666664,2.0781785218348965,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.49614543826777807,1.357616876180054,0.9174322759523261,2.24961,1.61168,1.0715212208880904,1.9306450000000002,1.6605656104440452,Uncertain,Uncertain,Neutral,Neutral,0.8294495490785843,0.866079440049904,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.2731,0.7558,-6.6322,-2.40147207040067,0.0034621877763093,Benign,0.9857,pathogenic,-3.492,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A189E,NP_000537:p.Ala189Glu,,,,,saturation_mutlist,,,,,,,,2.9765,1.1203619289398192,,2.280278547527195,,2.628389273763598,,Uncertain,Uncertain,,Uncertain,0.38783730625278856,,0.9989448161450619,2.83187,,0.9176187836728102,,1.874744391836405,,Uncertain,,Neutral,,0.6653842980825421,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.2451,0.7558,-3.9542,-3.04270652728897,0.0015664828591481,Benign,0.9731,pathogenic,-3.572,available,https://doi.org/10.1101/2022.10.22.513328 +A189F,NP_000537:p.Ala189Phe,,,,,saturation_mutlist,,,,,,,,2.84971,1.0514094305038453,,1.703013314520654,,2.276361657260327,,Uncertain,Uncertain,,Uncertain,0.4745070860750509,,1.0602368150254802,9.79734,,-0.3007988190908332,,4.748270590454584,,Uncertain,,Destabilizing,,0.24334654708026815,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.3212,0.7558,-22.2419,-4.92023944126789,0.2060104340334921,Benign,0.8472,pathogenic,-3.98,available,https://doi.org/10.1101/2022.10.22.513328 +A189G,NP_000537:p.Ala189Gly,"hg19,17:g.7578283G>C, hg38,17:g.7674965G>C",,,0.754,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1378428,Uncertain significance,1,,,,,1.43856,1.1869027757644652,1.7848033333333333,1.8269496035074546,1.6116816666666667,1.6327548017537272,Neutral,Neutral,Uncertain,Neutral,Neutral,0.3609871639356016,0.38820729044616814,0.35449237423428887,-0.18559,3.2675700000000005,1.6170602389311022,1.5409900000000003,0.7157351194655511,Uncertain,Neutral,Neutral,Neutral,0.9031657516019231,0.8491532127537859,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,damaging,,-0.2646,0.7558,-22.2419,-5.8316505052007,0.3429367489301889,Uncertain,0.6979,pathogenic,-3.724,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A189H,NP_000537:p.Ala189His,,,,,saturation_mutlist,,,,,,,,6.61025,0.7671575617790222,,1.9786061080279023,,4.294428054013951,,Uncertain,Neutral,,Destabilizing,0.36157973485666983,,1.0917110892170512,8.90738,,0.12930961785717712,,4.518344808928589,,Uncertain,,Destabilizing,,0.1844568377457342,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.3253,0.7558,-22.2419,-4.69013369362578,0.3720478102901257,Uncertain,0.956,pathogenic,-3.824,available,https://doi.org/10.1101/2022.10.22.513328 +A189I,NP_000537:p.Ala189Ile,,,,,saturation_mutlist,,,,,,,,3.63164,1.2277821588516236,,0.9023850061641618,,2.267012503082081,,Uncertain,Uncertain,,Uncertain,0.45491710674815417,,0.5024146529966373,3.05286,,-0.16529983217350364,,1.4437800839132482,,Uncertain,,Neutral,,0.358431627246813,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.2378,0.7558,-7.9541,-3.43688509217169,0.0904796685619637,Benign,0.798,pathogenic,-3.788,available,https://doi.org/10.1101/2022.10.22.513328 +A189K,NP_000537:p.Ala189Lys,,,,,saturation_mutlist,,,,,,,,4.66434,1.357308979034424,,3.14706448382267,,3.905702241911335,,Destabilizing,Uncertain,,Destabilizing,0.33399994843990494,,1.4281224200906353,4.08787,,0.9355026953273139,,2.5116863476636566,,Uncertain,,Uncertain,,0.7958446567400531,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.3431,0.7558,-22.2419,-6.004820990505,0.5242219220407693,Uncertain,0.9917,pathogenic,-3.926,available,https://doi.org/10.1101/2022.10.22.513328 +A189L,NP_000537:p.Ala189Leu,,,,,saturation_mutlist,,,,,,,,2.27979,1.3115646028518677,,0.8627440008938932,,1.5712670004469467,,Uncertain,Uncertain,,Neutral,0.41811659115518246,,0.4627514370328748,2.28902,,-0.5405275043812228,,0.8742462478093885,,Uncertain,,Neutral,,0.340625806356786,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.3154,0.7558,-22.2419,-4.39216905711053,0.5244701268616785,Uncertain,0.6483,pathogenic,-3.801,available,https://doi.org/10.1101/2022.10.22.513328 +A189M,NP_000537:p.Ala189Met,,,,,saturation_mutlist,,,,,,,,0.80253,1.1090764665603638,,1.1370276830876207,,0.9697788415438103,,Neutral,Uncertain,,Neutral,0.3422830976206198,,0.5997522168328046,1.74441,,-0.09509549580993039,,0.8246572520950348,,Neutral,,Neutral,,0.21648854610525844,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.2064,0.7558,-8.9541,-4.65583039918258,0.5882663799147319,Uncertain,0.8523,pathogenic,-3.891,available,https://doi.org/10.1101/2022.10.22.513328 +A189N,NP_000537:p.Ala189Asn,,,,,saturation_mutlist,,,,,,,,2.28683,1.308432595729828,,1.2303846055027712,,1.7586073027513858,,Uncertain,Uncertain,,Neutral,0.3564822340836539,,0.5564460855804219,2.55827,,0.4657530334141895,,1.5120115167070947,,Uncertain,,Neutral,,0.40523833333083975,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.2554,0.7558,-8.9541,-3.17248839464023,0.0946032624124289,Benign,0.959,pathogenic,-3.687,available,https://doi.org/10.1101/2022.10.22.513328 +A189P,NP_000537:p.Ala189Pro,"hg19,17:g.7578284C>G, hg38,17:g.7674966C>G",,,0.721,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.24092,0.8899094724655151,4.69025,3.1657970360568655,2.465585,1.7033585180284327,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.24696457492943097,3.498438045309173,1.7110930377286993,2.66738,5.06247,4.8126954623255775,3.8649250000000004,3.740037731162789,Uncertain,Uncertain,Destabilizing,Destabilizing,2.54136148772005,1.1207610688307659,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.3925,0.7558,-22.2419,-3.86587816946943,0.1983686632226752,Benign,0.7205,pathogenic,-3.503,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A189Q,NP_000537:p.Ala189Gln,,,,,saturation_mutlist,,,,,,,,3.47061,1.0604688215255738,,1.516790450994713,,2.4937002254973564,,Uncertain,Uncertain,,Uncertain,0.34667625626223514,,0.6834530153180088,3.14481,,0.5553569115991827,,1.8500834557995913,,Uncertain,,Neutral,,0.306757497715939,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.3206,0.7558,-22.2419,-4.38722572508395,0.5910490022299049,Uncertain,0.9461,pathogenic,-3.81,available,https://doi.org/10.1101/2022.10.22.513328 +A189R,NP_000537:p.Ala189Arg,,,,,saturation_mutlist,,,,,,,,6.57797,1.284566466808319,,2.3518562715997433,,4.464913135799872,,Uncertain,Uncertain,,Destabilizing,0.36808229940372716,,1.3055521534689134,5.92694,,0.34276098783922865,,3.1348504939196142,,Uncertain,,Destabilizing,,0.5314278723313969,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.3538,0.7558,-22.2419,-5.78252468356624,0.7110451905600786,Pathogenic,0.9618,pathogenic,-4.011,available,https://doi.org/10.1101/2022.10.22.513328 +A189S,NP_000537:p.Ala189Ser,"hg19,17:g.7578284C>A, hg38,17:g.7674966C>A",,,0.700,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528262,Uncertain significance,2,,,,,0.83245,0.6641248488426208,1.30363,1.1409016041648845,1.06804,0.9866758020824422,Neutral,Neutral,Neutral,Neutral,Neutral,0.2033042382346554,0.34580260881992586,0.32790375709054137,0.33548,0.2383233333333333,0.9438584211029831,0.28690166666666667,0.6396692105514916,Neutral,Neutral,Neutral,Neutral,0.6181325640094436,0.5530600884078951,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,uncertain,,-0.1578,0.7558,-6.9542,-2.63286801121178,0.0234409041587351,Benign,0.3994,ambiguous,-3.38,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A189T,NP_000537:p.Ala189Thr,"hg19,17:g.7578284C>T, hg38,17:g.7674966C>T",,,0.728,"COSMIC,ClinVar,saturation_mutlist",3972441,Uncertain significance,1,,,,,1.768,0.8379678416252136,1.6832200000000002,0.9940408380526481,1.72561,1.381020419026324,Neutral,Neutral,Neutral,Neutral,Neutral,0.26288139108787395,0.4067238044012997,0.4631382190347734,1.77482,1.3741466666666664,0.5696349190905524,1.5744833333333332,1.1722274595452762,Neutral,Neutral,Neutral,Neutral,1.4229662410924895,0.1599214422478602,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.1596,0.7558,-6.1468,-1.81167935946565,0.002830983688912,Benign,0.7003,pathogenic,-3.32,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A189V,NP_000537:p.Ala189Val,"hg19,17:g.7578283G>A, hg38,17:g.7674965G>A",,2.38617924979e-05,0.790,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12382,Conflicting classifications of pathogenicity,1,,,,,1.70237,0.6703456425666809,1.3209733333333336,0.36594227520067407,1.5116716666666667,1.034156137600337,Neutral,Neutral,Neutral,Neutral,Neutral,0.427586773084195,1.196630578870893,0.246514895926461,2.06915,1.2112233333333333,0.027117819293543954,1.6401866666666667,1.048133909646772,Uncertain,Uncertain,Neutral,Neutral,1.275447137603994,0.246817041070098,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.1591,0.7558,-6.6322,-2.91132196336471,0.0009732444417626,Benign,0.5887,pathogenic,-3.382,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A189W,NP_000537:p.Ala189Trp,,,,,saturation_mutlist,,,,,,,,6.90445,1.011071376800537,,2.41216505709964,,4.65830752854982,,Uncertain,Uncertain,,Destabilizing,0.5910754825576274,,1.657451914565964,15.04519,,-0.23191922919058286,,7.406635385404709,,Uncertain,,Destabilizing,,0.38873666218759356,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.3321,0.7558,-22.2419,-5.48234082674817,0.7889385000717355,Pathogenic,0.9773,pathogenic,-4.359,available,https://doi.org/10.1101/2022.10.22.513328 +A189Y,NP_000537:p.Ala189Tyr,,,,,saturation_mutlist,,,,,,,,3.47074,0.8349506878852844,,2.3537925346234636,,2.9122662673117317,,Uncertain,Neutral,,Uncertain,0.522736309625513,,1.331145364480697,11.18595,,0.018434245350095965,,5.602192122675048,,Uncertain,,Destabilizing,,0.06887287164479731,5.172,5.008,11.645,18.822,,False,5.172,,neutral,neutral,neutral,,False,11.645,,neutral,neutral,neutral,neutral,,-0.3403,0.7558,-22.2419,-4.69421519135877,0.4909475052359561,Uncertain,0.932,pathogenic,-4.054,available,https://doi.org/10.1101/2022.10.22.513328 +P190A,NP_000537:p.Pro190Ala,"hg19,17:g.7578281G>C, hg38,17:g.7674963G>C",,,0.757,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1021934,Uncertain significance,1,,,,,2.22507,1.299532573223114,1.14626,-0.22417842894076334,1.6856650000000002,1.0004457855296183,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.3640416944849301,0.32085820866337,0.08072920437916162,1.25862,0.5476199999999999,0.26266886589520616,0.9031199999999999,0.7606444329476031,Neutral,Neutral,Neutral,Neutral,0.9925948732824821,0.3691852049531381,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.1984,0.6122,-7.9483,-2.99567003362681,0.0256344382178636,Benign,0.4869,ambiguous,-3.395,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190C,NP_000537:p.Pro190Cys,,,,,saturation_mutlist,,,,,,,,2.6882,0.9577443170547485,,0.4596540847635879,,1.573927042381794,,Uncertain,Neutral,,Neutral,0.23281453411309497,,0.06712353067522374,2.15285,,0.7360484517694474,,1.4444492258847237,,Uncertain,,Neutral,,0.28136062232063275,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,uncertain,,-0.304,0.6122,-22.2361,-5.39324183254635,0.7982646144368102,Pathogenic,0.9435,pathogenic,-4.252,available,https://doi.org/10.1101/2022.10.22.513328 +P190D,NP_000537:p.Pro190Asp,,,,,saturation_mutlist,,,,,,,,2.61031,1.2844054317474365,,-0.3200020571310965,,1.1451539714344519,,Uncertain,Uncertain,,Neutral,0.273164413011489,,0.16611423656361993,2.56211,,0.6954122221340461,,1.628761111067023,,Uncertain,,Neutral,,0.2601435988812413,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,uncertain,,-0.3299,0.6122,-22.2361,-5.69329186827132,0.5860607029495021,Uncertain,0.9678,pathogenic,-4.256,available,https://doi.org/10.1101/2022.10.22.513328 +P190E,NP_000537:p.Pro190Glu,,,,,saturation_mutlist,,,,,,,,2.32396,1.6308633375167847,,-0.4888983705632776,,0.9175308147183612,,Uncertain,Uncertain,,Neutral,0.31824908168168387,,0.16107149650588695,2.74464,,0.7087546857929984,,1.7266973428964991,,Uncertain,,Neutral,,0.23440640422666467,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.3137,0.6122,-22.2361,-5.08079228164532,0.5154080921594626,Uncertain,0.9358,pathogenic,-3.988,available,https://doi.org/10.1101/2022.10.22.513328 +P190F,NP_000537:p.Pro190Phe,"hg38,17:g.7674962_7674963delinsAA",,,,"COSMIC,saturation_mutlist",,,,,,,,2.0293,1.5286181712150573,1.38934,-0.6328708194888899,1.70932,0.6982145902555551,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.32452822897710154,0.07865467945392698,0.18114880908869604,3.78094,3.480836666666667,-0.12060923496471844,3.6308883333333335,1.830165382517641,Destabilizing,Uncertain,Destabilizing,Neutral,2.4427272767998933,0.22285326734538866,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.3324,0.6122,-22.2361,-4.64609065702091,0.1673133879220692,Benign,0.966,pathogenic,-4.01,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190G,NP_000537:p.Pro190Gly,,,,,saturation_mutlist,,,,,,,,2.91011,1.7806654167175293,,0.5483762285705749,,1.7292431142852873,,Uncertain,Uncertain,,Neutral,0.3730681872197946,,0.0801943943644555,1.03939,,1.1142852770716136,,1.0768376385358067,,Neutral,,Neutral,,0.22732756671584067,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.2857,0.6122,-22.2361,-7.17116440263594,0.6999879865191387,Pathogenic,0.8994,pathogenic,-4.16,available,https://doi.org/10.1101/2022.10.22.513328 +P190H,NP_000537:p.Pro190His,"hg38,17:g.7674962G>T",,,0.731,"COSMIC,saturation_mutlist",,,,,,,,2.55686,1.175716860294342,1.2438766666666667,-0.674295310146642,1.9003683333333332,0.941282344926679,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.35280990830046044,0.36210456062057855,0.1019855768565734,4.37177,3.6252866666666663,0.100782357766457,3.998528333333333,2.2362761788832284,Destabilizing,Uncertain,Destabilizing,Uncertain,3.6860524638365573,0.056496987799995985,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.2151,0.6122,-3.6264,-3.24502230725534,0.000298703906099,Benign,0.7649,pathogenic,-3.575,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190I,NP_000537:p.Pro190Ile,"hg19,17:g.7578280_7578281delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,2.60739,1.68097398519516,,-0.5121713249026943,,1.0476093375486528,,Uncertain,Uncertain,,Neutral,0.3066677623864524,,0.15320197234068608,4.24564,,0.34895202967475036,,2.297296014837375,,Uncertain,,Uncertain,,0.36080586177078317,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.3155,0.6122,-22.2361,-5.72574202809181,0.6672094455933184,Uncertain,0.953,pathogenic,-4.004,available,https://doi.org/10.1101/2022.10.22.513328 +P190K,NP_000537:p.Pro190Lys,,,,,saturation_mutlist,,,,,,,,2.02178,1.43892662525177,,-0.343075460796702,,0.8393522696016491,,Uncertain,Uncertain,,Neutral,0.32701233082859754,,0.07049786760613502,2.78151,,0.6092042177031338,,1.6953571088515669,,Uncertain,,Neutral,,0.12967437926837752,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.3054,0.6122,-22.2361,-5.53443142894499,0.5577572913227822,Uncertain,0.9297,pathogenic,-3.996,available,https://doi.org/10.1101/2022.10.22.513328 +P190L,NP_000537:p.Pro190Leu,"hg19,17:g.7578280G>A, hg19,17:g.7674962G>A, hg38,17:g.7674962G>A",,,0.824,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",418517,Likely pathogenic,3,,,,,1.81919,1.4289805245399476,1.1264166666666666,-0.8222244311650356,1.4728033333333332,0.4984827844174822,Neutral,Neutral,Uncertain,Neutral,Neutral,0.2840641016428524,0.23508895484239345,0.09249970334253432,2.19419,1.5832233333333334,-0.36605566391975297,1.8887066666666668,0.9140671680401234,Uncertain,Uncertain,Neutral,Neutral,2.2932150740875183,0.3026031492361511,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.2523,0.6122,-8.9482,-5.71134636968457,0.1464515347828913,Benign,0.7083,pathogenic,-3.592,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190M,NP_000537:p.Pro190Met,,,,,saturation_mutlist,,,,,,,,1.82934,1.58764164686203,,-0.469854643449192,,0.679742678275404,,Neutral,Uncertain,,Neutral,0.2705151261252082,,0.07076468090643857,1.73671,,0.0023237556972265927,,0.8695168778486133,,Neutral,,Neutral,,0.2344776421163302,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.271,0.6122,-22.2361,-6.04764798472395,0.7422488729533716,Pathogenic,0.9414,pathogenic,-4.082,available,https://doi.org/10.1101/2022.10.22.513328 +P190N,NP_000537:p.Pro190Asn,"hg38,17:g.7674962_7674963delinsTT",,,,"COSMIC,saturation_mutlist",,,,,,,,2.55055,1.095666425228119,1.5261933333333333,-0.3120142689001004,2.0383716666666665,1.1192678655499497,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.3025885048061045,0.5314173481883665,0.12033092740053618,2.36641,2.3493166666666667,0.2796479146696221,2.3578633333333334,1.323028957334811,Uncertain,Uncertain,Uncertain,Neutral,1.5689900012924096,0.11606104833952133,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,uncertain,,-0.2222,0.6122,-7.3634,-3.83177689961355,0.0033214946249771,Benign,0.9398,pathogenic,-3.781,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190Q,NP_000537:p.Pro190Gln,,,,,saturation_mutlist,,,,,,,,2.34455,1.4723064494132996,,-0.25139034563051493,,1.0465798271847424,,Uncertain,Uncertain,,Neutral,0.309180998055279,,0.0673103763643932,2.70482,,0.45730682237269654,,1.5810634111863482,,Uncertain,,Neutral,,0.21622589879013665,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.2319,0.6122,-8.9482,-4.57232831602291,0.178679502272349,Benign,0.8424,pathogenic,-3.762,available,https://doi.org/10.1101/2022.10.22.513328 +P190R,NP_000537:p.Pro190Arg,"hg19,17:g.7578280G>C, hg19,17:g.7674962G>C, hg38,17:g.7674962G>C",,,0.846,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",234061,Conflicting classifications of pathogenicity,1,,,,,1.96427,1.5576887488365174,1.4692733333333334,-0.4917193178321879,1.7167716666666668,0.736275341083906,Neutral,Neutral,Uncertain,Neutral,Neutral,0.32306959147774295,0.18488335139276935,0.05168907023959062,3.47107,4.328456666666667,0.23094775734852413,3.8997633333333335,1.851008878674262,Destabilizing,Uncertain,Destabilizing,Neutral,3.182427121997018,0.22175509546442115,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.3412,0.6122,-22.2361,-5.59560735149418,0.2192902661998612,Benign,0.8268,pathogenic,-3.896,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190S,NP_000537:p.Pro190Ser,"hg19,17:g.7578281G>A, hg19,17:g.7674963G>A, hg38,17:g.7674963G>A",,,0.788,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",646725,Uncertain significance,2,,,,,2.71924,1.1952535820007324,1.57075,-0.19019224470125784,2.144995,1.264523877649371,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.31082631914551345,0.5487205432640554,0.16115479762596197,1.73787,1.4023833333333335,0.6462074995800936,1.570126666666667,1.1920387497900469,Neutral,Neutral,Neutral,Neutral,1.1391399695774391,0.18346490931631407,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.1981,0.6122,-7.9483,-3.5530655746616,0.0251230944650167,Benign,0.6927,pathogenic,-3.55,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190T,NP_000537:p.Pro190Thr,"hg19,17:g.7578281G>T, hg19,17:g.7674963G>T, hg38,17:g.7674963G>T",,,0.822,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",233197,Uncertain significance,2,,,,,3.29498,1.6353503274917602,1.41587,-0.21213894905842445,2.355425,1.5414205254707878,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.3758493142098249,0.38008216225793423,0.11516650530616346,3.39348,1.6998866666666668,0.6179071501615586,2.546683333333333,2.0056935750807794,Uncertain,Uncertain,Uncertain,Uncertain,0.7336105679143095,0.12831028663227906,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,uncertain,,-0.2832,0.6122,-22.2361,-5.26746995626814,0.0759742996170473,Benign,0.8083,pathogenic,-4.005,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190V,NP_000537:p.Pro190Val,,,,,saturation_mutlist,,,,,,,,2.97212,1.7418414855003357,,-0.35774317566190444,,1.3071884121690478,,Uncertain,Uncertain,,Neutral,0.35305782475603087,,0.1064910448435748,3.44917,,0.28014662540713875,,1.8646583127035694,,Uncertain,,Neutral,,0.3671959864730776,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.2709,0.6122,-22.2361,-5.61288001436523,0.4415117329516,Uncertain,0.8915,pathogenic,-3.816,available,https://doi.org/10.1101/2022.10.22.513328 +P190W,NP_000537:p.Pro190Trp,,,,,saturation_mutlist,,,,,,,,2.34225,1.618057243824005,,-1.0602640201245817,,0.6409929899377091,,Uncertain,Uncertain,,Neutral,0.3014460065354009,,0.2494151051110596,6.36722,,-0.3262900173483106,,3.0204649913258446,,Uncertain,,Destabilizing,,0.2635708054106895,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.345,0.6122,-22.2361,-5.29985898511672,0.8521025564993261,Pathogenic,0.9834,pathogenic,-4.59,available,https://doi.org/10.1101/2022.10.22.513328 +P190Y,NP_000537:p.Pro190Tyr,,,,,saturation_mutlist,,,,,,,,2.20665,1.3845783853530884,,-0.5935054829739893,,0.8065722585130053,,Uncertain,Uncertain,,Neutral,0.3271671161085957,,0.16443356314339008,5.01778,,0.0389064252985464,,2.5283432126492733,,Uncertain,,Uncertain,,0.22655491868737906,33.768,7.235,16.27,12.117,,False,33.768,,neutral,neutral,neutral,,False,16.27,,neutral,neutral,neutral,damaging,,-0.2605,0.6122,-7.9483,-3.50805252659365,0.0454933653739958,Benign,0.9581,pathogenic,-3.962,available,https://doi.org/10.1101/2022.10.22.513328 +P191A,NP_000537:p.Pro191Ala,"hg38,17:g.7674960G>C",,,0.598,"COSMIC,saturation_mutlist",,,,,,,,1.85188,0.6364661431312562,0.8213133333333333,-0.040373826929793535,1.3365966666666667,0.9057530865351032,Neutral,Neutral,Neutral,Neutral,Neutral,0.28484600984983854,0.29831278018586843,0.12342074209484752,1.66456,1.0055566666666667,0.22301244316807126,1.3350583333333335,0.9437862215840357,Neutral,Neutral,Neutral,Neutral,0.184589767562801,0.12034036177098102,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.105,1.3131,-2.2759,-1.57010272545414,3.446713775396139e-07,Benign,0.1423,benign,-3.14,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P191C,NP_000537:p.Pro191Cys,,,,,saturation_mutlist,,,,,,,,2.33522,0.5193735480308532,,0.7878929028607194,,1.5615564514303597,,Uncertain,Neutral,,Neutral,0.24804855377212004,,0.14151889473337032,2.1903,,0.7514229575034831,,1.4708614787517416,,Uncertain,,Neutral,,0.031122780486077115,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.2395,1.3131,-22.2361,-3.53127984662828,0.2023007847588735,Benign,0.8088,pathogenic,-4.004,available,https://doi.org/10.1101/2022.10.22.513328 +P191D,NP_000537:p.Pro191Asp,,,,,saturation_mutlist,,,,,,,,3.37995,1.2842239046096802,,0.7765450434683508,,2.0782475217341756,,Uncertain,Uncertain,,Uncertain,0.3891311620200394,,0.05865744458503804,2.25605,,0.11170482697399804,,1.1838774134869992,,Uncertain,,Neutral,,0.2077401377840544,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.2654,1.3131,-22.2361,-4.88970838450263,0.5556604817528131,Uncertain,0.945,pathogenic,-4.104,available,https://doi.org/10.1101/2022.10.22.513328 +P191E,NP_000537:p.Pro191Glu,,,,,saturation_mutlist,,,,,,,,2.29299,1.2646242904663085,,0.2830018503804825,,1.2879959251902413,,Uncertain,Uncertain,,Neutral,0.407791530852948,,0.030920424880175608,1.38047,,-0.011621735709543267,,0.6844241321452285,,Neutral,,Neutral,,0.05622880004596792,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.2492,1.3131,-22.2361,-4.79966390505317,0.2481910502566461,Benign,0.8377,pathogenic,-4.086,available,https://doi.org/10.1101/2022.10.22.513328 +P191F,NP_000537:p.Pro191Phe,,,,,saturation_mutlist,,,,,,,,3.21554,1.054395821094513,,-0.5607012647036976,,1.3274193676481512,,Uncertain,Uncertain,,Neutral,0.37921146527543204,,0.13160084661431537,2.45666,,-0.2662572511362948,,1.0952013744318525,,Uncertain,,Neutral,,0.1204981733368067,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.268,1.3131,-22.2361,-5.36434554185942,0.8001188617172952,Pathogenic,0.9425,pathogenic,-4.293,available,https://doi.org/10.1101/2022.10.22.513328 +P191G,NP_000537:p.Pro191Gly,,,,,saturation_mutlist,,,,,,,,2.41332,1.3879901361465454,,1.3177087564240422,,1.8655143782120212,,Uncertain,Uncertain,,Neutral,0.47727592921597195,,0.26068882666676496,1.79281,,0.7800888471207252,,1.2864494235603625,,Neutral,,Neutral,,0.11655468515803755,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.2212,1.3131,-22.2361,-4.6525734700151,0.1876182964457253,Benign,0.6704,pathogenic,-3.928,available,https://doi.org/10.1101/2022.10.22.513328 +P191H,NP_000537:p.Pro191His,"hg19,17:g.7578277G>T, hg38,17:g.7674959G>T",,3.9765226105e-06,0.797,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",853530,Uncertain significance,2,,,,,4.16784,0.6784083223342896,2.323583333333333,-0.16357687258501155,3.2457116666666668,2.0021315637074943,Uncertain,Uncertain,Neutral,Destabilizing,Uncertain,0.34023632067920634,0.5971984078084007,0.06312115129398797,2.72315,1.08855,-0.2888859174724086,1.90585,1.2171320412637956,Uncertain,Uncertain,Neutral,Neutral,0.28442641473674696,0.06002378338438375,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.2456,1.3131,-22.2361,-5.0015821412385,0.2613204073418738,Benign,0.6467,pathogenic,-3.944,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P191I,NP_000537:p.Pro191Ile,,,,,saturation_mutlist,,,,,,,,2.94039,1.1893755722045898,,-0.5671314665308888,,1.1866292667345555,,Uncertain,Uncertain,,Neutral,0.37332557559482504,,0.21736889493918735,2.02694,,-0.09272266879917947,,0.9671086656004103,,Uncertain,,Neutral,,0.4155879249637907,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.251,1.3131,-22.2361,-4.38680537016079,0.2245637859921811,Benign,0.8878,pathogenic,-4.01,available,https://doi.org/10.1101/2022.10.22.513328 +P191K,NP_000537:p.Pro191Lys,,,,,saturation_mutlist,,,,,,,,2.33146,0.917830069065094,,0.18421129918743281,,1.2578356495937164,,Uncertain,Neutral,,Neutral,0.49290416025402073,,0.041400933637521,1.67702,,-0.022506039231945562,,0.8272569803840272,,Neutral,,Neutral,,0.06197311383894186,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.1629,1.3131,-6.9483,-2.88333205684934,0.0103107752436759,Benign,0.7883,pathogenic,-3.838,available,https://doi.org/10.1101/2022.10.22.513328 +P191L,NP_000537:p.Pro191Leu,"hg19,17:g.7578277G>A, hg19,17:g.7674959G>A, hg38,17:g.7674959G>A",,3.9765226105e-06,0.748,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2703874,Uncertain significance,1,,,,,2.54642,1.0427678275108336,1.2263033333333333,-0.8325881714923525,1.8863616666666667,0.8569159142538236,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.37187165163525837,0.5988707468969318,0.025826956745794154,1.79815,0.7879833333333334,-0.41644286916748335,1.2930666666666666,0.6908535654162583,Neutral,Neutral,Neutral,Neutral,0.23704053694580504,0.3199196217900892,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.2556,1.3131,-22.2361,-4.30289476148818,0.1725939363228339,Benign,0.5851,pathogenic,-3.809,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P191M,NP_000537:p.Pro191Met,,,,,saturation_mutlist,,,,,,,,1.96913,1.079283392429352,,-0.3964447054122216,,0.7863426472938893,,Neutral,Uncertain,,Neutral,0.3116066022431499,,0.012693831169802347,1.95514,,-0.0786544727817721,,0.938242763609114,,Neutral,,Neutral,,0.208774800605523,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.2065,1.3131,-22.2361,-4.60463896300342,0.4343262898123536,Uncertain,0.8586,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328 +P191N,NP_000537:p.Pro191Asn,,,,,saturation_mutlist,,,,,,,,2.81201,0.8228482222557068,,0.3540880440591592,,1.5830490220295796,,Uncertain,Neutral,,Neutral,0.4165427796323805,,0.01926414704959837,2.20842,,0.03437427330246456,,1.121397136651232,,Uncertain,,Neutral,,0.11719246132111022,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.2336,1.3131,-22.2361,-4.37829278852242,0.222625439275989,Benign,0.8511,pathogenic,-3.953,available,https://doi.org/10.1101/2022.10.22.513328 +P191Q,NP_000537:p.Pro191Gln,,,,,saturation_mutlist,,,,,,,,2.52687,1.0197653698921203,,0.20773784975520013,,1.3673039248776002,,Uncertain,Uncertain,,Neutral,0.4009448145860639,,0.05809410719785802,1.73261,,0.15019803844848334,,0.9414040192242417,,Neutral,,Neutral,,0.14225001826908037,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.2353,1.3131,-22.2361,-4.99633471671181,0.0775838803730872,Benign,0.5141,ambiguous,-3.828,available,https://doi.org/10.1101/2022.10.22.513328 +P191R,NP_000537:p.Pro191Arg,"hg19,17:g.7578277G>C, hg38,17:g.7674959G>C",,1.19295678315e-05,0.617,"COSMIC,ClinVar,saturation_mutlist",127816,Likely benign,3,,,,,2.68085,0.9713789105415345,2.928343333333333,-0.38012486218531,2.8045966666666664,1.150362568907345,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.5184696562286224,1.8574530333108172,0.12985915696505532,1.7258,0.9692766666666667,-0.1958696710993455,1.3475383333333333,0.7649651644503273,Neutral,Neutral,Neutral,Neutral,0.3374947822148102,0.13470505875354985,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.1802,1.3131,-3.3337,-2.35161070148448,6.022513884568006e-06,Benign,0.5246,ambiguous,-3.579,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P191S,NP_000537:p.Pro191Ser,"hg19,17:g.7578278G>A, hg38,17:g.7674960G>A",,,0.722,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1024017,Uncertain significance,1,,,,,2.44844,0.7078486227989197,1.7713166666666667,0.37434086823294166,2.1098783333333335,1.411390434116471,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.31817009963493165,0.20256170489233363,0.14566973209590997,2.10683,0.9111066666666666,0.1816051709124351,1.5089683333333332,1.1442175854562175,Uncertain,Uncertain,Neutral,Neutral,0.2210255973612307,0.07043945528654104,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.1285,1.3131,-6.9483,-1.80852078612712,0.0055084348798353,Benign,0.3445,ambiguous,-3.499,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P191T,NP_000537:p.Pro191Thr,"hg38,17:g.7674960G>T",,,0.727,"COSMIC,saturation_mutlist",,,,,,,,2.93812,1.0929022598266602,1.7604300000000002,0.10846486328591341,2.349275,1.5232924316429568,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.3938241905680629,0.29064043295224207,0.06133728522180128,2.31206,1.0274400000000001,0.16227032946255526,1.66975,1.2371651647312776,Uncertain,Uncertain,Neutral,Neutral,0.2262150485710445,0.11940183116589025,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.2187,1.3131,-22.2361,-3.21332629010937,0.1440979354551821,Benign,0.5102,ambiguous,-3.75,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P191V,NP_000537:p.Pro191Val,,,,,saturation_mutlist,,,,,,,,2.48439,1.121042513847351,,-0.48729898522420356,,0.9985455073878982,,Uncertain,Uncertain,,Neutral,0.3423106180545364,,0.18340525013869752,2.20884,,-0.01882355377915648,,1.0950082231104217,,Uncertain,,Neutral,,0.3329630821527838,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.1386,1.3131,-8.9482,-3.95358254067611,0.0371820931343541,Benign,0.7007,pathogenic,-3.774,available,https://doi.org/10.1101/2022.10.22.513328 +P191W,NP_000537:p.Pro191Trp,,,,,saturation_mutlist,,,,,,,,4.35204,0.9540968918800354,,-1.140281380467142,,1.6058793097664288,,Uncertain,Neutral,,Neutral,0.35323357186160803,,0.14886181098684337,2.79329,,-0.5479070162850561,,1.1226914918574717,,Uncertain,,Neutral,,0.15646762770710007,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.2805,1.3131,-22.2361,-5.546325080267,0.8025260948811298,Pathogenic,0.9586,pathogenic,-4.48,available,https://doi.org/10.1101/2022.10.22.513328 +P191Y,NP_000537:p.Pro191Tyr,,,,,saturation_mutlist,,,,,,,,3.25968,0.8655650639533996,,-0.4064687664259819,,1.426605616787009,,Uncertain,Neutral,,Neutral,0.3249470482537759,,0.1399679809512988,2.41424,,-0.21149897167301046,,1.1013705141634946,,Uncertain,,Neutral,,0.03871671309595653,16.952,10.757,54.75,12.286,,False,16.952,,neutral,neutral,neutral,,False,54.75,,neutral,neutral,neutral,uncertain,,-0.2689,1.3131,-22.2361,-5.546325080267,0.7527720311309269,Pathogenic,0.9189,pathogenic,-4.373,available,https://doi.org/10.1101/2022.10.22.513328 +Q192A,NP_000537:p.Gln192Ala,,,,,saturation_mutlist,,,,,,,,0.58747,0.23411091804504394,,0.4281571412395346,,0.5078135706197673,,Neutral,Neutral,,Neutral,0.12663557861113695,,0.026335261338719867,0.00878,,0.25640518189535794,,0.13259259094767897,,Neutral,,Neutral,,0.25992397783228166,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.082,1.4461,-5.6264,-1.21954171838872,0.0020181554319966,Benign,0.2354,benign,-3.395,available,https://doi.org/10.1101/2022.10.22.513328 +Q192C,NP_000537:p.Gln192Cys,,,,,saturation_mutlist,,,,,,,,0.64666,0.06928117275238037,,1.014502706005693,,0.8305813530028465,,Neutral,Neutral,,Neutral,0.1805464833663168,,0.11791656730692028,0.12054,,0.7334249697105545,,0.42698248485527723,,Neutral,,Neutral,,0.18507456331044927,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.213,1.4461,-22.2361,-1.80142958859435,0.2424503298952133,Benign,0.7827,pathogenic,-3.72,available,https://doi.org/10.1101/2022.10.22.513328 +Q192D,NP_000537:p.Gln192Asp,,,,,saturation_mutlist,,,,,,,,1.66125,0.6504839670658111,,0.7049084791216057,,1.1830792395608027,,Neutral,Neutral,,Neutral,0.30570275758849325,,0.26410762548757566,-0.04665,,0.32040106303623767,,0.13687553151811882,,Neutral,,Neutral,,0.1852001985553903,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.1737,1.4461,-6.6264,-2.21723682565024,0.0012593948276139,Benign,0.5891,pathogenic,-3.38,available,https://doi.org/10.1101/2022.10.22.513328 +Q192E,NP_000537:p.Gln192Glu,"hg19,17:g.7578275G>C, hg38,17:g.7674957G>C",,,0.557,"ClinVar,saturation_mutlist",2679236,Uncertain significance,2,,,,,0.5081,0.37398176074028017,,0.4944487476462755,,0.5012743738231378,,Neutral,Neutral,,Neutral,0.1657254998657406,,0.18178100592978486,0.0204,,0.14628754689371248,,0.08334377344685624,,Neutral,,Neutral,,0.23348480528591767,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.0898,1.4461,-6.141,-1.16249853220175,0.0007421921406419,Benign,0.1097,benign,-3.264,available,https://doi.org/10.1101/2022.10.22.513328 +Q192F,NP_000537:p.Gln192Phe,,,,,saturation_mutlist,,,,,,,,0.0496,0.21127270698547362,,-0.38717927081015996,,-0.16878963540508,,Neutral,Neutral,,Neutral,0.2054502077454787,,0.22614699090187443,-0.30533,,-0.45245064597774737,,-0.3788903229888737,,Neutral,,Neutral,,0.1838272935249715,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.221,1.4461,-22.2361,-5.1254221930891,0.3981216306880295,Uncertain,0.8753,pathogenic,-4.05,available,https://doi.org/10.1101/2022.10.22.513328 +Q192G,NP_000537:p.Gln192Gly,,,,,saturation_mutlist,,,,,,,,1.24428,0.41120933532714843,,1.3293732206858235,,1.2868266103429118,,Neutral,Neutral,,Neutral,0.2703963122987318,,0.1926290697042333,0.25899,,1.1860050846999108,,0.7224975423499554,,Neutral,,Neutral,,0.40705702878348793,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.1492,1.4461,-4.9484,-2.51864708332323,2.804078525566736e-05,Benign,0.261,benign,-3.271,available,https://doi.org/10.1101/2022.10.22.513328 +Q192H,NP_000537:p.Gln192His,"hg19,17:g.7578273C>A, hg19,17:g.7578273C>G, hg19,17:g.7674955C>A, hg38,17:g.7674955C>A, hg38,17:g.7674955C>G",,,"0.534, 0.537","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","988617, 922531","Likely benign, Uncertain significance","1, 2",,,,,1.05918,-0.2965130853652954,0.38389999999999996,0.04747327080174516,0.72154,0.5533266354008726,Neutral,Neutral,Neutral,Neutral,Neutral,0.16497521495714085,0.47429280133689566,0.18676231873886928,0.2128,0.2649666666666667,-0.21415449042022602,0.23888333333333334,-0.0006772452101130172,Neutral,Neutral,Neutral,Neutral,0.4578999761471446,0.20717260599544768,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.0899,1.4461,-6.9483,-1.73335343456233,0.0084400897537684,Benign,0.3598,ambiguous,-3.366,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q192I,NP_000537:p.Gln192Ile,,,,,saturation_mutlist,,,,,,,,-0.00931,0.5992871499061585,,-0.036754712089807635,,-0.023032356044903817,,Neutral,Neutral,,Neutral,0.28426499650324494,,0.10331149847574425,0.09606,,-0.10887893603660494,,-0.006409468018302465,,Neutral,,Neutral,,0.22344546277213054,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.2024,1.4461,-22.2361,-5.24208629151928,0.4362013442337831,Uncertain,0.7849,pathogenic,-4.172,available,https://doi.org/10.1101/2022.10.22.513328 +Q192K,NP_000537:p.Gln192Lys,"hg38,17:g.7674957G>T",,,0.640,"COSMIC,saturation_mutlist",,,,,,,,-0.14611,-0.012416481971740714,0.72778,0.40599826238032616,0.290835,0.12994413119016307,Neutral,Neutral,Neutral,Neutral,Neutral,0.1923279690764424,0.3330228251436629,0.29720217164651647,-0.20787,0.6851466666666667,0.3036666296376673,0.23863833333333334,0.04789831481883364,Neutral,Neutral,Neutral,Neutral,0.15476377210302011,0.2662991808847576,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.2,1.4461,-22.2361,-3.90293857336837,0.1038913167874694,Benign,0.2843,benign,-3.626,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q192L,NP_000537:p.Gln192Leu,"hg19,17:g.7578274T>A, hg38,17:g.7674956T>A",,,0.718,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.41362,0.5280687928199768,0.31576333333333334,-0.27093818582992496,-0.048928333333333324,-0.3422790929149625,Neutral,Neutral,Neutral,Neutral,Neutral,0.22434885343665661,0.5564078315009194,0.0355041246193926,-0.50162,-0.17199333333333333,-0.4898325371504649,-0.33680666666666664,-0.4957262685752324,Neutral,Neutral,Neutral,Neutral,0.6256926732474622,0.20745665575485875,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.1857,1.4461,-22.2361,-4.30901436282833,0.2076676840873783,Benign,0.3186,benign,-3.672,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q192M,NP_000537:p.Gln192Met,,,,,saturation_mutlist,,,,,,,,-0.52106,0.45107603430747983,,0.16104209543320644,,-0.18000895228339675,,Neutral,Neutral,,Neutral,0.1553765460682201,,0.08085641769692628,-0.76982,,-0.19173418771997072,,-0.48077709385998535,,Neutral,,Neutral,,0.15485397186610228,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.1567,1.4461,-22.2361,-4.87898623365176,0.1590701352797799,Benign,0.5933,pathogenic,-3.78,available,https://doi.org/10.1101/2022.10.22.513328 +Q192N,NP_000537:p.Gln192Asn,,,,,saturation_mutlist,,,,,,,,0.90609,0.12139503240585327,,0.5279882986963109,,0.7170391493481554,,Neutral,Neutral,,Neutral,0.18611266023802073,,0.19751699523804986,-0.00258,,0.17369189882996294,,0.08555594941498147,,Neutral,,Neutral,,0.28946629776452715,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.1095,1.4461,-7.9483,-2.00161405568868,0.0004740024170053,Benign,0.3832,ambiguous,-3.424,available,https://doi.org/10.1101/2022.10.22.513328 +Q192P,NP_000537:p.Gln192Pro,"hg19,17:g.7578274T>G, hg38,17:g.7674956T>G",,,0.769,"ClinVar,saturation_mutlist",1036209,Uncertain significance,1,,,,,-0.12162,0.27278079628944396,4.403743333333334,1.977452481959266,2.141061666666667,0.927916240979633,Uncertain,Neutral,Neutral,Uncertain,Neutral,0.30980480310839664,1.0585279517749586,0.6218719104770293,-0.31147,5.428796666666667,2.2460107309142088,2.5586633333333335,0.9672703654571044,Uncertain,Uncertain,Uncertain,Neutral,0.45616028077371606,0.760418145798577,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.3404,1.4461,-22.2361,-5.41081355098746,0.1406338125413811,Benign,0.3204,benign,-3.549,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q192R,NP_000537:p.Gln192Arg,"hg19,17:g.7578274T>C, hg19,17:g.7674956T>C, hg38,17:g.7674956T>C",,,0.677,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182931,Conflicting classifications of pathogenicity,1,,,,,0.04788,0.0026626396179199275,0.5175733333333333,0.10639015971098616,0.2827266666666667,0.07713507985549307,Neutral,Neutral,Neutral,Neutral,Neutral,0.18051378164768692,0.25811942614912875,0.1981658123949254,0.14236,0.6018133333333333,-0.09851244938349842,0.3720866666666667,0.021923775308250786,Neutral,Neutral,Neutral,Neutral,0.4986382475859183,0.21475610432432857,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.1188,1.4461,-6.6264,-2.49721471871481,0.0020839843485994,Benign,0.2727,benign,-3.46,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q192S,NP_000537:p.Gln192Ser,,,,,saturation_mutlist,,,,,,,,1.03357,0.20149853706359863,,0.6823230344206559,,0.857946517210328,,Neutral,Neutral,,Neutral,0.20992111238099803,,0.16739752686515513,0.44713,,0.5833494916314755,,0.5152397458157378,,Neutral,,Neutral,,0.1865257995557247,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.0745,1.4461,-0.539,-1.25501259388064,3.394137530607636e-06,Benign,0.2403,benign,-3.092,available,https://doi.org/10.1101/2022.10.22.513328 +Q192T,NP_000537:p.Gln192Thr,,,,,saturation_mutlist,,,,,,,,1.34925,0.31756843090057374,,0.5378527560947755,,0.9435513780473878,,Neutral,Neutral,,Neutral,0.32226412431079476,,0.0904962881891599,0.74558,,0.3619741967449884,,0.5537770983724942,,Neutral,,Neutral,,0.19451572117766844,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.1951,1.4461,-22.2361,-2.58105989531754,0.0457492482205241,Benign,0.3754,ambiguous,-3.552,available,https://doi.org/10.1101/2022.10.22.513328 +Q192V,NP_000537:p.Gln192Val,,,,,saturation_mutlist,,,,,,,,0.37936,0.6225553047657013,,0.06914087196636699,,0.22425043598318348,,Neutral,Neutral,,Neutral,0.24785498891919247,,0.16190637616976308,0.18164,,-0.06315355658410866,,0.059243221707945666,,Neutral,,Neutral,,0.2164793900485305,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,uncertain,,-0.2025,1.4461,-22.2361,-4.57586104055003,0.2636363463082882,Benign,0.5828,pathogenic,-3.854,available,https://doi.org/10.1101/2022.10.22.513328 +Q192W,NP_000537:p.Gln192Trp,,,,,saturation_mutlist,,,,,,,,0.4171,0.2741312801837921,,-0.7908419392222333,,-0.18687096961111666,,Neutral,Neutral,,Neutral,0.23657095163051156,,0.25714667266474595,-0.00582,,-0.7335165662762906,,-0.3696682831381453,,Neutral,,Neutral,,0.20924416690477443,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.2204,1.4461,-22.2361,-5.1254221930891,0.7627597111538336,Pathogenic,0.8096,pathogenic,-4.266,available,https://doi.org/10.1101/2022.10.22.513328 +Q192Y,NP_000537:p.Gln192Tyr,,,,,saturation_mutlist,,,,,,,,0.21826,-0.11841007232666013,,-0.28856001299041795,,-0.03515000649520897,,Neutral,Neutral,,Neutral,0.2310949112909943,,0.20759142204060435,-0.31334,,-0.31818188920371043,,-0.3157609446018552,,Neutral,,Neutral,,0.17770043164971958,38.844,13.448,32.735,12.022,,False,38.844,,neutral,neutral,neutral,,False,32.735,,neutral,neutral,neutral,damaging,,-0.1555,1.4461,-8.9482,-4.80763491374168,0.2022236172012396,Benign,0.7393,pathogenic,-3.798,available,https://doi.org/10.1101/2022.10.22.513328 +H193A,NP_000537:p.His193Ala,,,,,saturation_mutlist,,,,,,,,0.53669,1.0325311183929444,,1.7479692469101942,,1.142329623455097,,Neutral,Uncertain,,Neutral,0.6927418504971609,,0.0731836057778838,-3.44149,,1.2080461041856527,,-1.1167219479071737,,Uncertain,,Neutral,,0.2382521800708923,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.2971,0.0001,-22.2419,-8.25135518731248,0.8650119547224437,Pathogenic,0.9991,pathogenic,-4.536,available,https://doi.org/10.1101/2022.10.22.513328 +H193C,NP_000537:p.His193Cys,,,,,saturation_mutlist,,,,,,,,0.18284,0.5567670321464538,,1.9803354259066168,,1.0815877129533085,,Neutral,Neutral,,Neutral,0.48453948959286613,,0.1481132443152687,-3.27612,,1.5825354599867423,,-0.8467922700066289,,Uncertain,,Neutral,,0.20659367518602378,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.3516,0.0001,-22.2419,-8.25135518731248,0.8691055971581964,Pathogenic,0.9677,pathogenic,-4.493,available,https://doi.org/10.1101/2022.10.22.513328 +H193D,NP_000537:p.His193Asp,"hg19,17:g.7578272G>C, hg19,17:g.7674954G>C, hg38,17:g.7674954G>C",,,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376613,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,1.10588,1.786409478187561,2.0880966666666665,2.6640947364085883,1.5969883333333332,1.8849873682042941,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.5780581549355386,0.5264247154996513,0.022674902340268473,-2.08295,1.29422,1.670949385318047,-0.39436499999999997,-0.2060003073409764,Uncertain,Uncertain,Neutral,Neutral,0.6744111678098657,0.4639858767366449,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.3443,0.0001,-22.2419,-7.14475957649214,0.8408680176603252,Pathogenic,0.998,pathogenic,-4.574,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H193E,NP_000537:p.His193Glu,,,,,saturation_mutlist,,,,,,,,1.35658,1.9190622901916503,,2.3739476790974052,,1.8652638395487027,,Uncertain,Uncertain,,Neutral,0.40854663382162126,,0.043084357528124756,-0.7746,,1.577575693430745,,0.4014878467153725,,Neutral,,Neutral,,0.20241935278613896,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.3558,0.0001,-22.2419,-7.14475957649214,0.8513434746720763,Pathogenic,0.9989,pathogenic,-4.636,available,https://doi.org/10.1101/2022.10.22.513328 +H193F,NP_000537:p.His193Phe,,,,,saturation_mutlist,,,,,,,,-0.41364,0.6521042108535766,,-0.9218639133039623,,-0.6677519566519812,,Neutral,Neutral,,Neutral,0.4167173089605942,,0.2801895591973912,1.37537,,-0.358755856730187,,0.5083070716349065,,Neutral,,Neutral,,0.4021302485196412,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.3187,0.0001,-22.2419,-4.26416354098304,0.7265980662693861,Pathogenic,0.983,pathogenic,-4.249,available,https://doi.org/10.1101/2022.10.22.513328 +H193G,NP_000537:p.His193Gly,,,,,saturation_mutlist,,,,,,,,1.8582,1.9177274751663207,,3.67615755319564,,2.76717877659782,,Uncertain,Uncertain,,Uncertain,0.4516035711957231,,0.128144915951833,-4.9142,,2.187684281519335,,-1.3632578592403326,,Uncertain,,Neutral,,0.30360738491592687,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.3796,0.0001,-22.2419,-8.25135518731248,0.8543686720263909,Pathogenic,0.999,pathogenic,-4.653,available,https://doi.org/10.1101/2022.10.22.513328 +H193I,NP_000537:p.His193Ile,,,,,saturation_mutlist,,,,,,,,-1.00585,1.060547523498535,,0.5426004219159832,,-0.23162478904200834,,Neutral,Uncertain,,Neutral,0.8305522894082484,,0.36229240530557427,1.14621,,0.8055533497254762,,0.9758816748627381,,Neutral,,Neutral,,0.35323506981214536,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.3833,0.0001,-22.2419,-8.25135518731248,0.8621369096099027,Pathogenic,0.9993,pathogenic,-4.706,available,https://doi.org/10.1101/2022.10.22.513328 +H193K,NP_000537:p.His193Lys,,,,,saturation_mutlist,,,,,,,,1.16495,1.377100121974945,,2.6074765100321495,,1.8862132550160746,,Uncertain,Uncertain,,Neutral,0.33546253349596267,,0.060366459085087615,0.93976,,1.481294096339407,,1.2105270481697035,,Neutral,,Neutral,,0.1945379292951761,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.34,0.0001,-22.2419,-7.00779851000983,0.8515214979902532,Pathogenic,0.9992,pathogenic,-4.515,available,https://doi.org/10.1101/2022.10.22.513328 +H193L,NP_000537:p.His193Leu,"hg19,17:g.7578271T>A, hg19,17:g.7674953T>A, hg38,17:g.7674953T>A",,,0.864,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",185822,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,-1.27803,1.2368619132041931,0.29535000000000006,0.20488610987387632,-0.49134,-0.5365719450630618,Neutral,Neutral,Uncertain,Neutral,Neutral,0.5830744351286598,0.5343792546497292,0.2923432143752335,-1.82479,-0.35963666666666666,0.016911713417814056,-1.0922133333333333,-0.9039391432910929,Neutral,Neutral,Neutral,Neutral,0.8979310880883653,0.23120600834891286,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.3469,0.0001,-22.2419,-8.25135518731248,0.8290371042772586,Pathogenic,0.9942,pathogenic,-4.525,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H193M,NP_000537:p.His193Met,,,,,saturation_mutlist,,,,,,,,-1.52526,1.1785416316986084,,0.5807004307214648,,-0.4722797846392676,,Neutral,Uncertain,,Neutral,0.49965241010891526,,0.2394125488495956,-2.5511,,0.44465678249519613,,-1.053221608752402,,Uncertain,,Neutral,,0.17296571564695054,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.297,0.0001,-22.2419,-8.25135518731248,0.8296537410534872,Pathogenic,0.9981,pathogenic,-4.667,available,https://doi.org/10.1101/2022.10.22.513328 +H193N,NP_000537:p.His193Asn,"hg19,17:g.7578272G>T, hg19,17:g.7578272_7578273delinsTT, hg19,17:g.7674954G>T, hg38,17:g.7674954G>T",,,0.875,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3460301,Pathogenic/Likely pathogenic,2,,,,,0.67644,0.90431715965271,1.3171199999999998,1.736992956126441,0.99678,1.2067164780632205,Neutral,Neutral,Neutral,Neutral,Neutral,0.3360182163272039,0.37998429520178867,0.22361316012026988,-2.42044,0.8464866666666667,0.9717068545808464,-0.7869766666666667,-0.7243665727095769,Uncertain,Uncertain,Neutral,Neutral,0.4325563221387734,0.36054443622914434,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.3038,0.0001,-22.2419,-7.14475957649214,0.8683567446247316,Pathogenic,0.9845,pathogenic,-4.157,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H193P,NP_000537:p.His193Pro,"hg19,17:g.7578271T>G, hg19,17:g.7674953T>G, hg38,17:g.7674953T>G",,,0.870,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376612,Pathogenic,3,,,,,1.60607,1.443773957490921,6.487303333333333,6.584911113083677,4.046686666666667,4.095490556541838,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.5371414978858321,0.7141247212419473,0.3707472251982916,4.9411,5.202493333333333,5.349988850002549,5.071796666666666,5.145544425001274,Destabilizing,Destabilizing,Destabilizing,Destabilizing,2.0335160914097097,0.654802863336632,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.4603,0.0001,-22.2419,-8.25135518731248,0.851502670906509,Pathogenic,0.9975,pathogenic,-4.494,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H193Q,NP_000537:p.His193Gln,"hg19,17:g.7578270A>C, hg19,17:g.7578270A>T, hg38,17:g.7674952A>T",,,0.807,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",825975,Conflicting classifications of pathogenicity,1,,,,,1.04537,1.2636013746261596,0.9375300000000001,1.6603834990757562,0.9914499999999999,1.3528767495378782,Neutral,Neutral,Uncertain,Neutral,Neutral,0.3420419891700257,0.35602168932056183,0.09511230278101668,-0.2593,0.6521533333333334,1.1584662482879982,0.1964266666666667,0.4495831241439991,Neutral,Neutral,Neutral,Neutral,0.44800379792536976,0.1952481443472233,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.2653,0.0001,-22.2419,-6.22965436600818,0.6323469453321534,Uncertain,0.9979,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H193R,NP_000537:p.His193Arg,"hg19,17:g.7578270_7578271delinsGC, hg19,17:g.7578271T>C, hg19,17:g.7674953T>C, hg38,17:g.7674953T>C",,,0.884,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",184979,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,3.05668,1.1796339130401612,1.9718799999999999,1.727851275416766,2.51428,2.392265637708383,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.32258263653537506,1.0746495402998442,0.010061885301656992,4.94137,4.16349,0.7986763885088456,4.55243,2.870023194254423,Destabilizing,Uncertain,Destabilizing,Uncertain,1.3312867953475187,0.14330198142734094,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.3334,0.0001,-22.2419,-5.99226010418964,0.8704227796314765,Pathogenic,0.9982,pathogenic,-4.324,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H193S,NP_000537:p.His193Ser,,,,,saturation_mutlist,,,,,,,,0.79335,1.0060798823833466,,2.7399475535145204,,1.7666487767572603,,Uncertain,Uncertain,,Neutral,0.6602813494015912,,0.0690475240274916,-2.90852,,1.7121121613838646,,-0.5982039193080678,,Uncertain,,Neutral,,0.27563508817240245,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.303,0.0001,-22.2419,-8.25135518731248,0.8254849465109046,Pathogenic,0.9971,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328 +H193T,NP_000537:p.His193Thr,,,,,saturation_mutlist,,,,,,,,0.26998,1.2637967705726623,,1.7516621492328415,,1.0108210746164208,,Neutral,Uncertain,,Neutral,0.6983372149141076,,0.16385160047834715,-0.41475,,1.5255841255900489,,0.5554170627950245,,Neutral,,Neutral,,0.24896892533578052,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.3479,0.0001,-22.2419,-8.25135518731248,0.8600364586907797,Pathogenic,0.9995,pathogenic,-4.547,available,https://doi.org/10.1101/2022.10.22.513328 +H193V,NP_000537:p.His193Val,,,,,saturation_mutlist,,,,,,,,-0.68239,0.9841787123680115,,0.7537677857332444,,0.03568889286662219,,Neutral,Neutral,,Neutral,0.9235651988647162,,0.21114158746083972,-0.1667,,0.8718922515279593,,0.3525961257639797,,Neutral,,Neutral,,0.33650719680088986,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.3397,0.0001,-22.2419,-8.25135518731248,0.8691793509928001,Pathogenic,0.9992,pathogenic,-4.628,available,https://doi.org/10.1101/2022.10.22.513328 +H193W,NP_000537:p.His193Trp,,,,,saturation_mutlist,,,,,,,,5.35997,0.7498676443099975,,-0.5990605486152578,,2.380454725692371,,Uncertain,Neutral,,Uncertain,0.46654007620340776,,0.20721060225201632,9.26488,,-0.3556672473197464,,4.454606376340127,,Uncertain,,Destabilizing,,0.3033490331697315,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.3349,0.0001,-22.2419,-4.9521636373717,0.8700682950850218,Pathogenic,0.9784,pathogenic,-4.694,available,https://doi.org/10.1101/2022.10.22.513328 +H193Y,NP_000537:p.His193Tyr,"hg19,17:g.7578272G>A, hg19,17:g.7674954G>A, hg38,17:g.7674954G>A",,,0.887,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",230256,Pathogenic/Likely pathogenic,2,,,,,3.04666,0.17220556259155273,-0.8608833333333333,-0.6132677121333254,1.0928883333333335,1.2166961439333375,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.3208877256020898,0.4096670542715823,0.22722787011831463,5.19893,1.0004533333333334,-0.06959124939784962,3.0996916666666667,2.564669375301075,Uncertain,Uncertain,Destabilizing,Uncertain,1.3154632507810913,0.4241545641519329,2.307,1.935,0.95,1.351,,False,2.307,,neutral,neutral,neutral,,False,0.95,,neutral,neutral,neutral,damaging,,-0.2689,0.0001,-22.2419,-4.01303053158416,0.5690906030896246,Uncertain,0.9627,pathogenic,-4.114,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194A,NP_000537:p.Leu194Ala,,,,,saturation_mutlist,,,,,,,,3.00928,1.076496922969818,,2.7790798199984708,,2.8941799099992354,,Uncertain,Uncertain,,Uncertain,0.2833532950945499,,0.1433783670607461,0.30676,,2.263813747316958,,1.285286873658479,,Uncertain,,Neutral,,0.3068732456965628,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.4176,0.021,-22.2419,-8.07358961589327,0.8583214048818935,Pathogenic,0.9926,pathogenic,-4.555,available,https://doi.org/10.1101/2022.10.22.513328 +L194C,NP_000537:p.Leu194Cys,,,,,saturation_mutlist,,,,,,,,2.82333,0.49460753440856936,,2.93407348823392,,2.87870174411696,,Uncertain,Neutral,,Uncertain,0.22024449548660877,,0.08771265158424574,0.47148,,2.4767743209316126,,1.4741271604658064,,Uncertain,,Neutral,,0.3368373294768797,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.4068,0.021,-22.2419,-8.07358961589327,0.8687044177666676,Pathogenic,0.9933,pathogenic,-4.5,available,https://doi.org/10.1101/2022.10.22.513328 +L194D,NP_000537:p.Leu194Asp,,,,,saturation_mutlist,,,,,,,,3.37002,1.5215885877609252,,3.5429416845096626,,3.456480842254831,,Destabilizing,Uncertain,,Destabilizing,0.307708494581934,,0.19324999675248986,2.12035,,3.425355110952483,,2.7728525554762413,,Uncertain,,Uncertain,,0.6223710709315499,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.5391,0.021,-22.2419,-8.07358961589327,0.8707121580009813,Pathogenic,0.9998,pathogenic,-4.789,available,https://doi.org/10.1101/2022.10.22.513328 +L194E,NP_000537:p.Leu194Glu,,,,,saturation_mutlist,,,,,,,,2.64808,1.536309323310852,,3.064461361435169,,2.856270680717585,,Uncertain,Uncertain,,Uncertain,0.2840647443335355,,0.20430049418131846,2.92934,,2.9592209953612643,,2.944280497680632,,Uncertain,,Uncertain,,0.5530757646839509,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.5072,0.021,-22.2419,-8.07358961589327,0.8690438677445209,Pathogenic,0.9993,pathogenic,-4.685,available,https://doi.org/10.1101/2022.10.22.513328 +L194F,NP_000537:p.Leu194Phe,"hg19,17:g.7578269G>A, hg19,17:g.7674951G>A, hg38,17:g.7674951G>A",,,0.851,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127817,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,2.2235,0.2672501540184021,2.185146666666667,0.8533645484857537,2.2043233333333334,1.5384322742428769,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.29708440977641637,0.7338882033994613,0.6257308120621509,5.42538,3.0096366666666667,1.2520152380376752,4.217508333333333,3.3386976190188373,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.6635939462418935,0.3007342407058881,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,neutral,,-0.2832,0.021,-8.9541,-5.28126106416149,0.0324725884338868,Benign,0.9428,pathogenic,-3.615,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194G,NP_000537:p.Leu194Gly,,,,,saturation_mutlist,,,,,,,,3.76891,1.4980147171020508,,4.239209650581769,,4.004059825290884,,Destabilizing,Uncertain,,Destabilizing,0.2999464286263098,,0.2128700922719943,-0.23637,,4.01119779566524,,1.8874138978326198,,Uncertain,,Neutral,,0.6453274802488339,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.4924,0.021,-22.2419,-8.07358961589327,0.8685993851998238,Pathogenic,0.9986,pathogenic,-4.724,available,https://doi.org/10.1101/2022.10.22.513328 +L194H,NP_000537:p.Leu194His,"hg19,17:g.7578268A>T, hg19,17:g.7674950A>T, hg38,17:g.7674950A>T",,,0.918,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376634,Conflicting classifications of pathogenicity,1,,,,,2.7418,1.2666562032699584,3.156236666666667,2.084814276221414,2.9490183333333335,2.413307138110707,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.38579080776363267,0.9518335015934015,0.44282037334291474,4.95439,3.46236,2.1202143492263086,4.208375,3.5373021746131545,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.5482537577314602,0.27025973064500536,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.46,0.021,-22.2419,-6.32813408679831,0.8707985517890111,Pathogenic,0.9974,pathogenic,-4.47,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194I,NP_000537:p.Leu194Ile,"hg19,17:g.7578269G>T, hg38,17:g.7674951G>T",,,0.791,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.82045,-0.1740307903289795,1.1739233333333334,0.7707829023252278,0.9971866666666667,0.7956164511626139,Neutral,Neutral,Neutral,Neutral,Neutral,0.1448731550024787,1.2230444089602344,0.17527521584028424,1.14182,3.3614533333333334,0.9245459956267067,2.2516366666666667,1.0331829978133533,Uncertain,Neutral,Uncertain,Neutral,0.6671541439244424,0.07756410355732156,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.2917,0.021,-22.2419,-3.75098857645665,0.3824737590859234,Uncertain,0.5835,pathogenic,-3.668,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194K,NP_000537:p.Leu194Lys,,,,,saturation_mutlist,,,,,,,,3.51053,1.4570089554786683,,3.5349847052934833,,3.5227573526467415,,Destabilizing,Uncertain,,Destabilizing,0.328931195684668,,0.25893624858276837,4.99628,,3.61734097551129,,4.306810487755644,,Destabilizing,,Destabilizing,,1.1067433022340714,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.5062,0.021,-22.2419,-8.07358961589327,0.8630146072540739,Pathogenic,0.9978,pathogenic,-4.64,available,https://doi.org/10.1101/2022.10.22.513328 +L194M,NP_000537:p.Leu194Met,,,,,saturation_mutlist,,,,,,,,0.03602,0.2882845401763916,,1.1230961702935174,,0.5795580851467587,,Neutral,Neutral,,Neutral,0.15805137891374318,,0.18662836469066424,0.30245,,1.5644475827596247,,0.9334487913798124,,Neutral,,Neutral,,0.23866979251838324,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.315,0.021,-22.2419,-3.95420430738313,0.8500422283408849,Pathogenic,0.8253,pathogenic,-4.008,available,https://doi.org/10.1101/2022.10.22.513328 +L194N,NP_000537:p.Leu194Asn,,,,,saturation_mutlist,,,,,,,,3.36464,1.4809625244140625,,2.7146969372660705,,3.0396684686330353,,Uncertain,Uncertain,,Destabilizing,0.2998681809958458,,0.1306383377183567,1.85183,,2.446608121187961,,2.1492190605939805,,Uncertain,,Uncertain,,0.39671592628282276,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.4854,0.021,-22.2419,-8.07358961589327,0.8700870557873067,Pathogenic,0.9987,pathogenic,-4.65,available,https://doi.org/10.1101/2022.10.22.513328 +L194P,NP_000537:p.Leu194Pro,"hg19,17:g.7578268A>G, hg19,17:g.7674950A>G, hg38,17:g.7674950A>G",,,0.937,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376635,Uncertain significance,1,,,Tier I - Strong,1,2.0025,1.225865843296051,2.826416666666667,5.244182457443951,2.414458333333333,3.6233412287219755,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,0.24128586165970495,0.975974549440484,0.8311143408273513,1.65489,5.6499999999999995,5.439326724892729,3.6524449999999997,3.5471083624463646,Uncertain,Uncertain,Destabilizing,Destabilizing,0.6116962377411413,1.9240696233263481,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.501,0.021,-22.2419,-8.07358961589327,0.8452217603580727,Pathogenic,0.9989,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194Q,NP_000537:p.Leu194Gln,,,,,saturation_mutlist,,,,,,,,2.77017,1.3923110485076904,,2.5140011060198777,,2.642085553009939,,Uncertain,Uncertain,,Uncertain,0.3446916295995229,,0.1803322893614766,2.79874,,2.361528346122902,,2.580134173061451,,Uncertain,,Uncertain,,0.37231001082207205,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.4384,0.021,-22.2419,-8.07358961589327,0.8661059872690757,Pathogenic,0.9979,pathogenic,-4.415,available,https://doi.org/10.1101/2022.10.22.513328 +L194R,NP_000537:p.Leu194Arg,"hg19,17:g.7578268A>C, hg19,17:g.7674950A>C, hg38,17:g.7674950A>C",,3.9763644895e-06,0.933,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376633,Conflicting classifications of pathogenicity,1,,,,,5.18274,1.4946806478500365,7.147506666666666,2.6163098916970693,6.165123333333333,3.8995249458485346,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.314196575769222,1.2717439672180697,0.2018492908564696,8.03285,6.8146233333333335,2.690899834150901,7.423736666666667,5.3618749170754505,Destabilizing,Uncertain,Destabilizing,Destabilizing,2.804227577929834,0.739154044183102,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,neutral,,-0.4978,0.021,-22.2419,-8.07358961589327,0.8708434893456363,Pathogenic,0.9952,pathogenic,-4.526,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194S,NP_000537:p.Leu194Ser,,,,,saturation_mutlist,,,,,,,,3.88437,1.2761913228034973,,3.431932380331785,,3.6581511901658925,,Destabilizing,Uncertain,,Destabilizing,0.32369241564250406,,0.1270357757138511,1.25794,,3.0081333755348543,,2.133036687767427,,Uncertain,,Uncertain,,0.5231124892895238,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.448,0.021,-22.2419,-8.07358961589327,0.8706631324317787,Pathogenic,0.9988,pathogenic,-4.459,available,https://doi.org/10.1101/2022.10.22.513328 +L194T,NP_000537:p.Leu194Thr,,,,,saturation_mutlist,,,,,,,,3.18686,1.134716601371765,,2.5652596889355848,,2.8760598444677923,,Uncertain,Uncertain,,Uncertain,0.26762281394322557,,0.21576974189068346,1.31901,,2.146769643493547,,1.7328898217467734,,Uncertain,,Neutral,,0.34012720693457055,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.4207,0.021,-22.2419,-8.07358961589327,0.8597017778433296,Pathogenic,0.9936,pathogenic,-4.477,available,https://doi.org/10.1101/2022.10.22.513328 +L194V,NP_000537:p.Leu194Val,"hg19,17:g.7578269G>C, hg38,17:g.7674951G>C",,,0.833,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.65251,0.18654484987258912,0.4192766666666666,1.1863082014817679,1.0358933333333333,1.419409100740884,Neutral,Neutral,Neutral,Neutral,Neutral,0.11614137184648357,0.6754434334733163,0.2632149550309707,0.74298,2.16043,1.1790082502108898,1.451705,0.9609941251054449,Uncertain,Neutral,Neutral,Neutral,0.16037071573908573,0.1323163791946554,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,uncertain,,-0.328,0.021,-22.2419,-4.06512820151916,0.1112249142806883,Benign,0.7109,pathogenic,-3.694,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194W,NP_000537:p.Leu194Trp,,,,,saturation_mutlist,,,,,,,,4.60358,0.42155290365219117,,1.264388327726917,,2.9339841638634585,,Uncertain,Neutral,,Uncertain,0.4723874865502885,,0.5808243708387448,12.57949,,1.7461563175632835,,7.1628231587816416,,Uncertain,,Destabilizing,,0.3675255390066067,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,neutral,,-0.4502,0.021,-22.2419,-5.78917545840285,0.4702581870887263,Uncertain,0.9939,pathogenic,-4.234,available,https://doi.org/10.1101/2022.10.22.513328 +L194Y,NP_000537:p.Leu194Tyr,,,,,saturation_mutlist,,,,,,,,3.38914,0.6594461345672608,,1.4670218470560814,,2.4280809235280407,,Uncertain,Neutral,,Uncertain,0.39163886251316515,,0.7194293308181383,8.57042,,1.7751618491559136,,5.172790924577957,,Uncertain,,Destabilizing,,0.2724200134480328,3.196,2.087,0.605,0.735,,False,3.196,,neutral,neutral,neutral,,False,0.605,,neutral,neutral,neutral,neutral,,-0.4431,0.021,-22.2419,-6.32813408679831,0.867127404636066,Pathogenic,0.996,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328 +I195A,NP_000537:p.Ile195Ala,"hg19,17:g.7578265_7578266delinsGC",,,,"cBioPortal,saturation_mutlist",,,,,,,,3.63575,2.3056858253479002,,2.9327098252194443,,3.284229912609722,,Uncertain,Destabilizing,,Destabilizing,0.17987303440943178,,0.1708476433789002,0.5952,,2.2512238568463094,,1.4232119284231546,,Uncertain,,Neutral,,0.8979766514550289,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,neutral,,-0.4013,0.2723,-22.2419,-6.41975022589998,0.8708148865193323,Pathogenic,0.9945,pathogenic,-4.256,available,https://doi.org/10.1101/2022.10.22.513328 +I195C,NP_000537:p.Ile195Cys,,,,,saturation_mutlist,,,,,,,,2.60103,1.4620544576644898,,2.8255351710068624,,2.713282585503431,,Uncertain,Uncertain,,Uncertain,0.18609293181449618,,0.1294061658074483,0.68791,,2.444335088705909,,1.5661225443529545,,Uncertain,,Neutral,,0.8187585443257255,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,neutral,,-0.3812,0.2723,-22.2419,-5.40924899061051,0.8627193598446419,Pathogenic,0.9942,pathogenic,-4.24,available,https://doi.org/10.1101/2022.10.22.513328 +I195D,NP_000537:p.Ile195Asp,,,,,saturation_mutlist,,,,,,,,3.70171,3.2693651485443116,,4.124998945551778,,3.9133544727758887,,Destabilizing,Destabilizing,,Destabilizing,0.18876463028051035,,0.21581883874778252,2.27671,,3.4151957951811447,,2.845952897590572,,Uncertain,,Uncertain,,0.8346565634833802,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,neutral,,-0.5253,0.2723,-22.2419,-7.4631744305005,0.870846191076935,Pathogenic,0.9999,pathogenic,-4.552,available,https://doi.org/10.1101/2022.10.22.513328 +I195E,NP_000537:p.Ile195Glu,,,,,saturation_mutlist,,,,,,,,3.14551,2.9659357261657715,,3.4657092514244625,,3.305609625712231,,Destabilizing,Destabilizing,,Destabilizing,0.21179957913118178,,0.2772992139786988,1.46086,,2.8700878616455774,,2.1654739308227886,,Uncertain,,Uncertain,,0.9025736639065001,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,neutral,,-0.5062,0.2723,-22.2419,-7.4631744305005,0.8683509906837552,Pathogenic,0.9993,pathogenic,-4.527,available,https://doi.org/10.1101/2022.10.22.513328 +I195F,NP_000537:p.Ile195Phe,"hg19,17:g.7578266T>A, hg19,17:g.7674948T>A, hg38,17:g.7674948T>A",,,0.904,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376617,Conflicting classifications of pathogenicity,1,,,,,4.27244,1.209632501602173,1.5351466666666667,1.50146314093394,2.9037933333333332,2.88695157046697,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.29095225408524383,0.7787357821637723,0.1819686241546877,4.47777,1.5395666666666667,1.009920610528429,3.008668333333333,2.743845305264214,Uncertain,Uncertain,Destabilizing,Uncertain,0.3572920614225225,0.5308410093252585,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,damaging,,-0.3622,0.2723,-22.2419,-6.96272216613622,0.6398104291326352,Uncertain,0.9288,pathogenic,-4.077,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195G,NP_000537:p.Ile195Gly,,,,,saturation_mutlist,,,,,,,,4.69998,3.0218503952026365,,5.0726288497302185,,4.886304424865109,,Destabilizing,Destabilizing,,Destabilizing,0.1686256662929939,,0.16374355614456956,1.74145,,4.117397429904689,,2.9294237149523443,,Uncertain,,Uncertain,,0.8407384493621142,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,neutral,,-0.4919,0.2723,-22.2419,-7.4631744305005,0.8708474002638746,Pathogenic,0.999,pathogenic,-4.52,available,https://doi.org/10.1101/2022.10.22.513328 +I195H,NP_000537:p.Ile195His,,,,,saturation_mutlist,,,,,,,,4.47957,2.5664594078063967,,2.5288744352196435,,3.5042222176098217,,Uncertain,Destabilizing,,Destabilizing,0.26443272856420413,,0.25728791848981025,4.44078,,2.1008415707258856,,3.2708107853629427,,Uncertain,,Destabilizing,,0.7759663769965223,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,neutral,,-0.4918,0.2723,-22.2419,-6.96272216613622,0.8580669810492387,Pathogenic,0.9992,pathogenic,-4.382,available,https://doi.org/10.1101/2022.10.22.513328 +I195K,NP_000537:p.Ile195Lys,"hg19,17:g.7578264_7578265delinsTT, hg38,17:g.7674946_7674947delinsTT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,3.35357,2.6294832324981687,5.282536666666666,4.257743590797398,4.318053333333333,3.805656795398699,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.19806160795348535,0.9768416034115027,0.2655206544231224,2.78266,5.668026666666667,3.2986139332926783,4.225343333333333,3.040636966646339,Uncertain,Uncertain,Destabilizing,Destabilizing,0.17767825496916842,0.8606701644071458,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,uncertain,,-0.4987,0.2723,-22.2419,-7.4631744305005,0.8636284613371448,Pathogenic,0.9982,pathogenic,-4.424,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195L,NP_000537:p.Ile195Leu,"hg38,17:g.7674948T>G",,,0.724,"COSMIC,saturation_mutlist",,,,,,,,-0.00195,0.7107790756225586,0.8274366666666667,0.2889621897033547,0.41274333333333335,0.14350609485167734,Neutral,Neutral,Neutral,Neutral,Neutral,0.1897260556768114,0.3077720310374042,0.10368663389633456,-0.39678,0.37448999999999993,0.6139645440544402,-0.011145000000000044,0.1085922720272201,Neutral,Neutral,Neutral,Neutral,0.6822617998002428,0.4497807383573297,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,uncertain,,-0.2025,0.2723,-5.7843,-2.06454558168875,0.0189015191667626,Benign,0.2338,benign,-3.298,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195M,NP_000537:p.Ile195Met,"hg19,17:g.7578264G>C, hg19,17:g.7674946G>C, hg38,17:g.7674946G>C",,,0.755,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376620,Uncertain significance,2,,,,,0.0294,1.1545397138595581,1.0507933333333332,1.2064063240547604,0.5400966666666667,0.6179031620273803,Neutral,Neutral,Uncertain,Neutral,Neutral,0.2334311446836412,0.9070249806311228,0.1336610408538416,-0.94227,1.52857,1.1570346493906614,0.29314999999999997,0.10738232469533066,Neutral,Neutral,Neutral,Neutral,0.33016179558917275,0.4611503524402952,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,uncertain,,-0.2141,0.2723,-6.9542,-2.07380098452234,0.0514837251885732,Benign,0.4112,ambiguous,-3.592,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195N,NP_000537:p.Ile195Asn,"hg19,17:g.7578264_7578265delinsAT, hg19,17:g.7578265A>T, hg19,17:g.7674947A>T, hg38,17:g.7674946_7674947delinsAT, hg38,17:g.7674947A>T",,,0.840,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","3656084, 376618","Uncertain significance, Conflicting classifications of pathogenicity","1, 1",Likely oncogenic,1,Tier I - Strong,1,2.78213,3.008361930847168,3.526076666666667,2.7865141626618075,3.1541033333333335,2.7843220813309038,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,0.19563765909417527,0.1593893100416574,0.10070763575914825,2.10444,3.49864,2.2889079244376114,2.80154,2.1966739622188056,Uncertain,Uncertain,Uncertain,Uncertain,0.08736249653026179,0.7808687235267773,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,neutral,,-0.4384,0.2723,-22.2419,-7.4631744305005,0.8622897999050234,Pathogenic,0.998,pathogenic,-4.375,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195P,NP_000537:p.Ile195Pro,,,,,saturation_mutlist,,,,,,,,3.6825,2.6569169330596925,,5.714161367044935,,4.698330683522467,,Destabilizing,Destabilizing,,Destabilizing,0.14399926482030512,,0.10081146831128086,0.96101,,5.103212207227989,,3.0321111036139943,,Uncertain,,Destabilizing,,1.7643321799884446,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,neutral,,-0.5453,0.2723,-22.2419,-7.4631744305005,0.8651780772994634,Pathogenic,0.9979,pathogenic,-4.543,available,https://doi.org/10.1101/2022.10.22.513328 +I195Q,NP_000537:p.Ile195Gln,,,,,saturation_mutlist,,,,,,,,2.56274,2.7383602046966553,,2.566561145899892,,2.5646505729499456,,Uncertain,Destabilizing,,Uncertain,0.2338964563119492,,0.174106172615243,1.38523,,2.1726906150303553,,1.7789603075151776,,Uncertain,,Neutral,,0.6753566534695365,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,neutral,,-0.4659,0.2723,-22.2419,-7.4631744305005,0.8706324413626758,Pathogenic,0.9973,pathogenic,-4.372,available,https://doi.org/10.1101/2022.10.22.513328 +I195R,NP_000537:p.Ile195Arg,,,,,saturation_mutlist,,,,,,,,4.11455,2.6450417709350584,,3.3573721266042775,,3.735961063302139,,Destabilizing,Destabilizing,,Destabilizing,0.19480005878766077,,0.29892305876997777,5.83702,,2.4094971714102393,,4.12325858570512,,Uncertain,,Destabilizing,,0.802551410110795,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,damaging,,-0.5255,0.2723,-22.2419,-7.4631744305005,0.8701150865360756,Pathogenic,0.9977,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +I195S,NP_000537:p.Ile195Ser,"hg19,17:g.7578265A>C, hg19,17:g.7674947A>C, hg38,17:g.7674947A>C",,,0.865,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376619,Conflicting classifications of pathogenicity,1,,,,,4.36039,2.7916218852996826,4.1161,3.800041446909729,4.238245,4.080215723454865,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.19866319885233694,0.6187019228998726,0.25632347872104755,1.72188,4.40567,3.0700420192349434,3.0637749999999997,2.395961009617472,Uncertain,Uncertain,Destabilizing,Uncertain,0.3338636399290385,0.9419467525767514,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,neutral,,-0.4418,0.2723,-22.2419,-6.41975022589998,0.870823739348777,Pathogenic,0.9967,pathogenic,-4.265,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195T,NP_000537:p.Ile195Thr,"hg19,17:g.7578265A>G, hg19,17:g.7674947A>G, hg38,17:g.7674947A>G",,0.0,0.851,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",216077,Pathogenic,2,Oncogenic,1,Tier I - Strong,1,2.71755,2.2757306146621703,2.5997733333333333,2.469545457979091,2.6586616666666667,2.5935477289895457,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,0.1799233572763534,0.2862239303218529,0.1774377669982332,1.15071,2.941266666666667,2.0512656126529163,2.0459883333333333,1.600987806326458,Uncertain,Uncertain,Uncertain,Neutral,0.3171656548591323,0.8074106572434694,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,neutral,,-0.2908,0.2723,-8.9541,-6.41975022589998,0.8700765958698575,Pathogenic,0.9962,pathogenic,-4.176,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195V,NP_000537:p.Ile195Val,"hg19,17:g.7578266T>C",,,0.725,"cBioPortal,saturation_mutlist",,,,,,,,0.98131,0.7761574077606201,0.95612,0.6479513946211334,0.968715,0.8146306973105667,Neutral,Neutral,Neutral,Neutral,Neutral,0.10053014250163561,0.18664210832499725,0.08330405677624352,-0.33415,1.0551033333333333,0.5446095842988647,0.36047666666666667,0.10522979214943237,Neutral,Neutral,Neutral,Neutral,0.23377505218098496,0.6336670312771298,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,neutral,,-0.1707,0.2723,-7.3692,-2.02257112956522,0.0098289755978255,Benign,0.4167,ambiguous,-3.287,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195W,NP_000537:p.Ile195Trp,,,,,saturation_mutlist,,,,,,,,7.73617,1.5893058347702027,,2.66925932168334,,5.20271466084167,,Uncertain,Uncertain,,Destabilizing,0.3396779427735805,,0.3216775662656436,14.49022,,1.6500288323304193,,8.07012441616521,,Uncertain,,Destabilizing,,0.7294746410176811,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,damaging,,-0.4511,0.2723,-22.2419,-6.41894482551988,0.8669599728249571,Pathogenic,0.9984,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328 +I195Y,NP_000537:p.Ile195Tyr,,,,,saturation_mutlist,,,,,,,,6.64464,1.6706265163421632,,2.574091434174056,,4.609365717087028,,Uncertain,Uncertain,,Destabilizing,0.31800340827178875,,0.18948579633457055,6.57159,,1.6863629611049937,,4.128976480552497,,Uncertain,,Destabilizing,,0.7533038392787239,4.334,1.934,1.515,1.678,,False,4.334,,neutral,neutral,neutral,,False,1.515,,neutral,neutral,neutral,damaging,,-0.46,0.2723,-22.2419,-6.96272216613622,0.8694001414318939,Pathogenic,0.9948,pathogenic,-4.516,available,https://doi.org/10.1101/2022.10.22.513328 +R196A,NP_000537:p.Arg196Ala,,,,,saturation_mutlist,,,,,,,,0.57606,0.35439995765686033,,1.6247531479221606,,1.1004065739610804,,Neutral,Neutral,,Neutral,0.38941613738625225,,0.2572927105401085,-0.62488,,1.7412702379196865,,0.5581951189598433,,Neutral,,Neutral,,0.2456136665035711,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.4017,0.0888,-22.239,-6.64890589971673,0.7358404843656337,Pathogenic,0.9941,pathogenic,-4.313,available,https://doi.org/10.1101/2022.10.22.513328 +R196C,NP_000537:p.Arg196Cys,,,,,saturation_mutlist,,,,,,,,0.16007,0.3165866327285767,,2.140818231088653,,1.1504441155443266,,Uncertain,Neutral,,Neutral,0.3516886880851387,,0.29356035964005295,-0.701,,1.9953892770296833,,0.6471946385148417,,Neutral,,Neutral,,0.15438098706306738,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.4106,0.0888,-22.239,-6.78318923477795,0.4002826077062367,Uncertain,0.906,pathogenic,-4.251,available,https://doi.org/10.1101/2022.10.22.513328 +R196D,NP_000537:p.Arg196Asp,,,,,saturation_mutlist,,,,,,,,1.8895,0.9832499480247497,,2.6473760283426153,,2.2684380141713074,,Uncertain,Neutral,,Uncertain,0.5711091785905225,,0.24477324124477123,1.75048,,2.620055246892273,,2.1852676234461366,,Uncertain,,Uncertain,,0.11767760372043001,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.4927,0.0888,-22.239,-6.71430815062119,0.8426073284211704,Pathogenic,0.9986,pathogenic,-4.61,available,https://doi.org/10.1101/2022.10.22.513328 +R196E,NP_000537:p.Arg196Glu,,,,,saturation_mutlist,,,,,,,,0.78862,0.8569002401828766,,2.0461005986571394,,1.4173602993285697,,Uncertain,Neutral,,Neutral,0.4203091012597437,,0.27756516124141467,1.11622,,2.0074779086339345,,1.5618489543169671,,Uncertain,,Neutral,,0.11351085893319895,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.438,0.0888,-22.239,-6.64558155308853,0.7994082140234413,Pathogenic,0.9856,pathogenic,-4.361,available,https://doi.org/10.1101/2022.10.22.513328 +R196F,NP_000537:p.Arg196Phe,,,,,saturation_mutlist,,,,,,,,0.20652,0.5032671523094178,,0.2602662865203888,,0.2333931432601944,,Neutral,Neutral,,Neutral,0.27628332710387327,,0.1752361817337467,3.8747,,0.22578792846334247,,2.050243964231671,,Uncertain,,Uncertain,,0.3274499349482141,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.4339,0.0888,-22.239,-6.86749286846446,0.8613463913088969,Pathogenic,0.9938,pathogenic,-4.615,available,https://doi.org/10.1101/2022.10.22.513328 +R196G,NP_000537:p.Arg196Gly,"hg19,17:g.7578263G>C, hg38,17:g.7674945G>C",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",232344,Conflicting classifications of pathogenicity,1,,,,,1.15514,0.6656744694709777,3.012583333333333,2.9780800232483506,2.0838616666666665,2.0666100116241752,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.5741451941506441,0.9472318416077216,0.16986191266278444,-0.07276,2.6585066666666664,3.0375016574862648,1.292873333333333,1.4823708287431323,Uncertain,Uncertain,Neutral,Neutral,0.15273053074687526,0.2004417828190954,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.4371,0.0888,-22.239,-7.80629060075436,0.8610839621556761,Pathogenic,0.9907,pathogenic,-4.501,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R196H,NP_000537:p.Arg196His,,,,,saturation_mutlist,,,,,,,,0.75978,0.4264964032173157,,1.124399587717754,,0.942089793858877,,Neutral,Neutral,,Neutral,0.2777710622575028,,0.23517796951805217,4.86746,,1.1650165929453207,,3.0162382964726606,,Uncertain,,Destabilizing,,0.21506654085564017,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.3715,0.0888,-22.239,-6.06941447909736,0.076309712736068,Benign,0.8171,pathogenic,-3.864,available,https://doi.org/10.1101/2022.10.22.513328 +R196I,NP_000537:p.Arg196Ile,,,,,saturation_mutlist,,,,,,,,-0.50469,0.3937175762653351,,0.7133446947422554,,0.1043273473711277,,Neutral,Neutral,,Neutral,0.2848215281315784,,0.42835168139720425,-0.37997,,0.2235296464678029,,-0.07822017676609853,,Neutral,,Neutral,,0.44587555240609233,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.4311,0.0888,-22.239,-5.71104484075269,0.7013335812488991,Pathogenic,0.9865,pathogenic,-4.354,available,https://doi.org/10.1101/2022.10.22.513328 +R196K,NP_000537:p.Arg196Lys,,,,,saturation_mutlist,,,,,,,,-0.31543,0.367828232049942,,1.6092356765330285,,0.6469028382665143,,Neutral,Neutral,,Neutral,0.11056476269756671,,0.1589167198889033,-0.73858,,1.7434274801573626,,0.5024237400786813,,Neutral,,Neutral,,0.06896361307478373,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,uncertain,,-0.2919,0.0888,-22.239,-4.418970792279,0.3801983393151043,Uncertain,0.8812,pathogenic,-3.894,available,https://doi.org/10.1101/2022.10.22.513328 +R196L,NP_000537:p.Arg196Leu,"hg19,17:g.7578261_7578262delinsAA, hg19,17:g.7578262C>A, hg38,17:g.7674944C>A",,,0.933,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",100814,Conflicting classifications of pathogenicity,1,,,,,-1.21991,0.44261247038841245,-0.15895666666666666,0.3237599858030764,-0.6894333333333333,-0.4480750070984618,Neutral,Neutral,Neutral,Neutral,Neutral,0.2591101001591123,0.3098966742139852,0.19486922665103798,-1.41331,-0.6586166666666666,-0.0652281934403413,-1.0359633333333333,-0.7392690967201707,Neutral,Neutral,Neutral,Neutral,0.796528098911492,0.11450013386956596,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.4041,0.0888,-22.239,-5.82925530448756,0.150822334273034,Benign,0.9763,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R196M,NP_000537:p.Arg196Met,,,,,saturation_mutlist,,,,,,,,-1.16006,0.4052315926551819,,0.7705924496629741,,-0.19473377516851298,,Neutral,Neutral,,Neutral,0.24856046938909443,,0.21798155247829662,-1.80773,,0.5359096224192523,,-0.6359101887903739,,Neutral,,Neutral,,0.11347318881110223,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.37,0.0888,-22.239,-6.18972325937347,0.830974248692133,Pathogenic,0.9927,pathogenic,-4.451,available,https://doi.org/10.1101/2022.10.22.513328 +R196N,NP_000537:p.Arg196Asn,,,,,saturation_mutlist,,,,,,,,0.86959,0.7311963772773743,,1.8906305719903027,,1.3801102859951513,,Neutral,Neutral,,Neutral,0.38182588911705956,,0.23797587437345685,0.4387,,1.7502593484053264,,1.0944796742026632,,Neutral,,Neutral,,0.22969210019927214,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.4166,0.0888,-22.239,-6.71430815062119,0.7271140237400785,Pathogenic,0.9966,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328 +R196P,NP_000537:p.Arg196Pro,"hg19,17:g.7578262C>G, hg19,17:g.7674944C>G, hg38,17:g.7674944C>G",,,0.941,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",231165,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,3.5289,1.9314751863479613,3.033443333333333,4.735555692409329,3.2811716666666664,4.132227846204664,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.46966487983236527,0.6594024650814977,0.655912006739626,3.65912,3.566893333333333,5.451497498068832,3.6130066666666663,4.555308749034416,Destabilizing,Destabilizing,Destabilizing,Destabilizing,1.3751767782684845,2.1529798141160157,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.5438,0.0888,-22.239,-7.80629060075436,0.8349213564549759,Pathogenic,0.9985,pathogenic,-4.472,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R196Q,NP_000537:p.Arg196Gln,"hg19,17:g.7578262C>T, hg19,17:g.7674944C>T, hg38,17:g.7674944C>T",,3.9763961127e-06,0.888,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",216467,Uncertain significance,3,,,,,0.00979,0.46593135118484497,0.3202933333333333,1.6171845144509247,0.16504166666666667,0.8134872572254623,Neutral,Neutral,Neutral,Neutral,Neutral,0.3112330528347234,0.32018813035811033,0.3154428985088408,-0.14431,0.8901333333333333,1.5835691516455006,0.37291166666666664,0.7196295758227503,Neutral,Neutral,Neutral,Neutral,0.4188294135113032,0.12347197922989782,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.2984,0.0888,-6.9513,-4.08074164295966,0.0004966294292797,Benign,0.8076,pathogenic,-3.602,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R196S,NP_000537:p.Arg196Ser,,,,,saturation_mutlist,,,,,,,,0.7528,0.39110383272171023,,2.1906526115859415,,1.4717263057929708,,Uncertain,Neutral,,Neutral,0.4460830126480617,,0.30150969378036346,-0.14432,,2.2211088169408173,,1.0383944084704086,,Uncertain,,Neutral,,0.23319997003180143,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.4022,0.0888,-22.239,-6.78318923477795,0.6013356277325125,Uncertain,0.9935,pathogenic,-4.229,available,https://doi.org/10.1101/2022.10.22.513328 +R196T,NP_000537:p.Arg196Thr,,,,,saturation_mutlist,,,,,,,,0.71055,0.25311659574508666,,1.783152294071823,,1.2468511470359114,,Neutral,Neutral,,Neutral,0.4216577535479046,,0.26405830774112565,-0.09685,,1.5499781593866395,,0.7265640796933197,,Neutral,,Neutral,,0.31189092041209826,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.4066,0.0888,-22.239,-5.81935586418579,0.1785502843952184,Benign,0.9897,pathogenic,-4.069,available,https://doi.org/10.1101/2022.10.22.513328 +R196V,NP_000537:p.Arg196Val,,,,,saturation_mutlist,,,,,,,,-0.33581,0.343471497297287,,0.9236049109999498,,0.2938974554999749,,Neutral,Neutral,,Neutral,0.3491229616252402,,0.4532870689352537,-0.65572,,0.4235924953713488,,-0.11606375231432559,,Neutral,,Neutral,,0.35900801455321035,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.4182,0.0888,-22.239,-6.75880658149217,0.8409901664940158,Pathogenic,0.9843,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +R196W,NP_000537:p.Arg196Trp,,,,,saturation_mutlist,,,,,,,,0.03367,0.5856923687458039,,0.10167195820675878,,0.0676709791033794,,Neutral,Neutral,,Neutral,0.2779450844993829,,0.22612986782979635,5.82042,,0.11485369190058514,,2.9676368459502926,,Uncertain,,Uncertain,,0.3278385914901949,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.3516,0.0888,-8.9511,-4.38737167945949,0.2708822355643782,Benign,0.8582,pathogenic,-4.151,available,https://doi.org/10.1101/2022.10.22.513328 +R196Y,NP_000537:p.Arg196Tyr,,,,,saturation_mutlist,,,,,,,,0.66181,0.4871160292625427,,0.5472128214792129,,0.6045114107396065,,Neutral,Neutral,,Neutral,0.27012913686625384,,0.20072479636658222,5.99256,,0.578769579019829,,3.2856647895099145,,Uncertain,,Destabilizing,,0.3220544730358319,14.527,6.751,16.345,9.355,,False,14.527,,neutral,neutral,neutral,,False,16.345,,neutral,neutral,neutral,damaging,,-0.4232,0.0888,-22.239,-6.86749286846446,0.640133902391459,Uncertain,0.9837,pathogenic,-4.514,available,https://doi.org/10.1101/2022.10.22.513328 +V197A,NP_000537:p.Val197Ala,"hg19,17:g.7578259A>G, hg38,17:g.7674941A>G",,,0.823,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3460294,Uncertain significance,1,,,,,3.29051,1.7655873847007753,2.854083333333333,2.874869571122653,3.0722966666666665,3.0826897855613264,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.4561297196549355,0.3978460553474868,0.3164919173090391,-0.61782,2.3849199999999997,1.601997075980121,0.8835499999999998,0.49208853799006047,Uncertain,Neutral,Neutral,Neutral,1.2895120965957112,0.4071573351146795,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.3211,0.325,-22.2419,-3.5206512021933,0.1405968956305145,Benign,0.7733,pathogenic,-3.596,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V197C,NP_000537:p.Val197Cys,,,,,saturation_mutlist,,,,,,,,2.34953,1.2475172519683837,,2.58448061220046,,2.46700530610023,,Uncertain,Uncertain,,Uncertain,0.35147199880091523,,0.15911189520313668,-0.60226,,1.941437298391551,,0.6695886491957755,,Neutral,,Neutral,,0.21600368549705426,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.349,0.325,-22.2419,-4.11406857854048,0.130186544083736,Benign,0.9432,pathogenic,-3.758,available,https://doi.org/10.1101/2022.10.22.513328 +V197D,NP_000537:p.Val197Asp,,,,,saturation_mutlist,,,,,,,,4.52863,2.7815694761276246,,4.367283437423057,,4.447956718711529,,Destabilizing,Destabilizing,,Destabilizing,0.318927552975401,,0.21282716189326753,2.48313,,3.0671506990724278,,2.7751403495362137,,Uncertain,,Uncertain,,0.45257613720606876,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.4877,0.325,-22.2419,-6.8456697360114,0.846129836186183,Pathogenic,0.9975,pathogenic,-4.615,available,https://doi.org/10.1101/2022.10.22.513328 +V197E,NP_000537:p.Val197Glu,"hg19,17:g.7578259A>T, hg38,17:g.7674941A>T",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634757,Uncertain significance,2,,,,,4.41414,2.8783000326156616,3.6272133333333336,4.432458535734084,4.020676666666667,4.423299267867042,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.3301871208325724,0.5779576958182626,0.41187894474196907,3.51462,4.840703333333333,2.654149674274439,4.177661666666666,3.084384837137219,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.8775350194088487,0.7129836420420913,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,uncertain,,-0.445,0.325,-22.2419,-6.8456697360114,0.8548744800576837,Pathogenic,0.9891,pathogenic,-4.52,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V197F,NP_000537:p.Val197Phe,,,,,saturation_mutlist,,,,,,,,6.33335,1.863324146270752,,2.6644107763159357,,4.498880388157968,,Uncertain,Uncertain,,Destabilizing,0.45246562079357355,,0.6471081967945401,6.44148,,0.168681638474761,,3.305080819237381,,Uncertain,,Destabilizing,,0.16497788231284233,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.3982,0.325,-22.2419,-6.8456697360114,0.8588739220888657,Pathogenic,0.9737,pathogenic,-4.387,available,https://doi.org/10.1101/2022.10.22.513328 +V197G,NP_000537:p.Val197Gly,"hg19,17:g.7578259A>C, hg19,17:g.7674941A>C, hg38,17:g.7674941A>C",,,0.914,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",826051,Uncertain significance,2,,,,,4.8937,2.893754014968872,5.35578,4.9494276464723015,5.12474,4.92156382323615,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.436906467316721,0.32239378933223883,0.24349274156808853,0.08738,4.901813333333334,3.6649477248012556,2.494596666666667,1.8761638624006278,Uncertain,Uncertain,Uncertain,Neutral,1.1077693720365362,0.5080767816577193,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.4469,0.325,-22.2419,-6.75265058190232,0.7291351710970796,Pathogenic,0.9,pathogenic,-4.21,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V197H,NP_000537:p.Val197His,,,,,saturation_mutlist,,,,,,,,6.05756,2.673496265411377,,3.4891684242441996,,4.773364212122099,,Destabilizing,Destabilizing,,Destabilizing,0.437096185603265,,0.5400644161368033,6.06991,,1.3386858231039562,,3.7042979115519783,,Uncertain,,Destabilizing,,0.06979187270683215,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.4907,0.325,-22.2419,-6.8456697360114,0.8572879802209521,Pathogenic,0.9986,pathogenic,-4.547,available,https://doi.org/10.1101/2022.10.22.513328 +V197I,NP_000537:p.Val197Ile,,,,,saturation_mutlist,,,,,,,,0.45327,0.4245812129974365,,0.6743506256342267,,0.5638103128171134,,Neutral,Neutral,,Neutral,0.2466871499042376,,0.25639992335926765,0.44953,,0.35000715851643277,,0.3997685792582164,,Neutral,,Neutral,,0.13101905272109854,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.1735,0.325,-5.9542,-1.9131308579423,0.0012986975083848,Benign,0.2531,benign,-3.411,available,https://doi.org/10.1101/2022.10.22.513328 +V197K,NP_000537:p.Val197Lys,,,,,saturation_mutlist,,,,,,,,4.57184,2.8703044176101686,,5.533500727263184,,5.0526703636315915,,Destabilizing,Destabilizing,,Destabilizing,0.33841400543648326,,0.8744095581566091,3.25341,,3.1146739706927917,,3.184041985346396,,Destabilizing,,Destabilizing,,0.8136702708402809,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.4839,0.325,-22.2419,-7.33996685341231,0.8520019517034036,Pathogenic,0.9954,pathogenic,-4.566,available,https://doi.org/10.1101/2022.10.22.513328 +V197L,NP_000537:p.Val197Leu,"hg19,17:g.7578260C>A, hg19,17:g.7578260C>G, hg19,17:g.7674942C>A, hg19,17:g.7674942C>G, hg38,17:g.7674942C>A, hg38,17:g.7674942C>G",,,0.730,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","480766, 216468","Uncertain significance, Uncertain significance","2, 2",,,,,1.19491,1.46034601688385,2.1028366666666667,1.725168219326972,1.6488733333333334,1.460039109663486,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.2888746845565149,0.7037578506055112,0.26580121652088196,-0.01222,2.0171200000000002,-0.13145293827121077,1.00245,-0.07183646913560539,Uncertain,Neutral,Neutral,Neutral,0.8880986320223672,0.36257443180205706,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.2488,0.325,-7.9541,-2.53947494754032,0.3558336004282653,Uncertain,0.9179,pathogenic,-3.801,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V197M,NP_000537:p.Val197Met,"hg19,17:g.7578260C>T, hg19,17:g.7674942C>T, hg38,17:g.7674942C>T",,0.0,0.758,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",188060,Likely pathogenic,3,Likely oncogenic,1,,,1.70043,1.904227397441864,2.3290266666666666,2.5468492858536744,2.0147283333333332,2.1236396429268374,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.3429318810709377,0.8092124970337246,0.28664743008439003,-0.29481,2.7541966666666666,0.4713087163655689,1.2296933333333333,0.08824935818278445,Uncertain,Neutral,Neutral,Neutral,0.5529780755951259,0.38889806248067144,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.2468,0.325,-5.7843,-2.05747489701612,0.0076628390895927,Benign,0.8149,pathogenic,-3.648,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V197N,NP_000537:p.Val197Asn,,,,,saturation_mutlist,,,,,,,,3.65832,2.918762164115906,,3.0110303780080376,,3.3346751890040185,,Destabilizing,Destabilizing,,Destabilizing,0.40066151618476886,,0.3037225624632641,1.31069,,1.8186547679726681,,1.5646723839863341,,Neutral,,Neutral,,0.18592519003740168,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.4755,0.325,-22.2419,-6.30858040479212,0.782372239375825,Pathogenic,0.9925,pathogenic,-4.332,available,https://doi.org/10.1101/2022.10.22.513328 +V197P,NP_000537:p.Val197Pro,,,,,saturation_mutlist,,,,,,,,3.89772,2.1899438953399657,,5.9938176152024125,,4.9457688076012065,,Destabilizing,Destabilizing,,Destabilizing,0.5314758535851706,,0.2649848076751246,0.99992,,5.531222933616693,,3.2655714668083466,,Uncertain,,Destabilizing,,0.24791620806760575,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.5254,0.325,-22.2419,-7.33996685341231,0.8615156025895383,Pathogenic,0.9945,pathogenic,-4.412,available,https://doi.org/10.1101/2022.10.22.513328 +V197Q,NP_000537:p.Val197Gln,,,,,saturation_mutlist,,,,,,,,4.23219,2.7829941082000733,,3.522507267174774,,3.877348633587387,,Destabilizing,Destabilizing,,Destabilizing,0.32717061074657766,,0.3582616516540083,2.62398,,1.6732356043453656,,2.1486078021726827,,Uncertain,,Uncertain,,0.48582517289359256,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,uncertain,,-0.4556,0.325,-22.2419,-6.8456697360114,0.8505247353890255,Pathogenic,0.9879,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328 +V197R,NP_000537:p.Val197Arg,"hg38,17:g.7674941_7674942delinsCT",,,,"COSMIC,saturation_mutlist",,,,,,,,6.84056,2.9924700450897217,4.41304,4.568114749092049,5.626799999999999,5.704337374546025,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.32788199770662196,0.35981029362707223,0.9116015201935875,6.22022,8.498416666666666,2.031157321192714,7.3593183333333325,4.125688660596357,Destabilizing,Uncertain,Destabilizing,Destabilizing,2.103480159803959,0.6151817586009821,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.5049,0.325,-22.2419,-7.33996685341231,0.8364061701708466,Pathogenic,0.9904,pathogenic,-4.592,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V197S,NP_000537:p.Val197Ser,,,,,saturation_mutlist,,,,,,,,4.06089,2.5339937591552735,,3.6804070172000087,,3.870648508600004,,Destabilizing,Destabilizing,,Destabilizing,0.4324431609831243,,0.21908272229575493,-0.27995,,2.6711186229216715,,1.1955843114608358,,Uncertain,,Neutral,,0.40132375660526987,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.4247,0.325,-22.2419,-4.42691594893359,0.1897258266101767,Benign,0.9227,pathogenic,-3.851,available,https://doi.org/10.1101/2022.10.22.513328 +V197T,NP_000537:p.Val197Thr,,,,,saturation_mutlist,,,,,,,,2.4369,1.9713399410247803,,2.4079789863692977,,2.422439493184649,,Uncertain,Uncertain,,Uncertain,0.3098299403843077,,0.15268782894914995,0.40725,,1.800589188842621,,1.1039195944213105,,Neutral,,Neutral,,0.16999916917266716,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.3401,0.325,-22.2419,-5.13381694120456,0.4763366100635526,Uncertain,0.8551,pathogenic,-3.963,available,https://doi.org/10.1101/2022.10.22.513328 +V197W,NP_000537:p.Val197Trp,,,,,saturation_mutlist,,,,,,,,14.05194,2.2359912467002867,,3.9076442751314584,,8.97979213756573,,Destabilizing,Destabilizing,,Destabilizing,0.522831626783698,,0.8129659721618905,12.58254,,0.5546716017894013,,6.568605800894701,,Uncertain,,Destabilizing,,0.16610028338668034,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.3659,0.325,-7.9541,-4.36016292295742,0.7931015519995008,Pathogenic,0.9992,pathogenic,-4.497,available,https://doi.org/10.1101/2022.10.22.513328 +V197Y,NP_000537:p.Val197Tyr,,,,,saturation_mutlist,,,,,,,,7.56391,2.2518630385398866,,3.5244405194537562,,5.544175259726878,,Destabilizing,Destabilizing,,Destabilizing,0.5149275234493073,,0.582740346031127,9.75531,,0.6758167652719833,,5.215563382635992,,Uncertain,,Destabilizing,,0.07794283089451383,6.965,2.204,1.025,1.123,,False,6.965,,neutral,neutral,neutral,,False,1.025,,neutral,neutral,neutral,damaging,,-0.4417,0.325,-22.2419,-6.8456697360114,0.8449027975939047,Pathogenic,0.9974,pathogenic,-4.382,available,https://doi.org/10.1101/2022.10.22.513328 +E198A,NP_000537:p.Glu198Ala,,,,,saturation_mutlist,,,,,,,,0.63554,0.25299074411392214,,0.21820718794671104,,0.4268735939733555,,Neutral,Neutral,,Neutral,0.23725767650220692,,0.01789427913365372,-0.20225,,0.3214464567138117,,0.059598228356905855,,Neutral,,Neutral,,0.16421601797146712,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3144,0.0678,-22.2419,-5.98921774853301,0.6718263963587653,Uncertain,0.9123,pathogenic,-4.047,available,https://doi.org/10.1101/2022.10.22.513328 +E198C,NP_000537:p.Glu198Cys,,,,,saturation_mutlist,,,,,,,,0.59695,-0.18080130815505982,,0.8384051499809,,0.71767757499045,,Neutral,Neutral,,Neutral,0.20427876291238647,,0.08861284449521085,0.1032,,0.9075336503943197,,0.5053668251971598,,Neutral,,Neutral,,0.23309784757477764,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3838,0.0678,-22.2419,-6.34137386382184,0.8517998083968643,Pathogenic,0.9925,pathogenic,-4.444,available,https://doi.org/10.1101/2022.10.22.513328 +E198D,NP_000537:p.Glu198Asp,"hg19,17:g.7578255T>A",,,0.824,"cBioPortal,saturation_mutlist",,,,,,,,0.29176,0.1660876083374023,0.29796,0.27754026292071493,0.29486,0.28465013146035745,Neutral,Neutral,Neutral,Neutral,Neutral,0.14078792877811555,0.3507704465886486,0.15998677771907507,-0.03877,0.08957,0.34372660000711613,0.0254,0.15247830000355805,Neutral,Neutral,Neutral,Neutral,0.06661834632191546,0.08432830865616796,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.2801,0.0678,-22.2419,-2.9993919025193,0.0381818939802717,Benign,0.9126,pathogenic,-3.552,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E198F,NP_000537:p.Glu198Phe,,,,,saturation_mutlist,,,,,,,,-0.13879,0.0472121560573578,,-0.2577432239928162,,-0.1982666119964081,,Neutral,Neutral,,Neutral,0.3677695998040695,,0.1347872227660952,-0.01025,,-0.26235259809179157,,-0.13630129904589577,,Neutral,,Neutral,,0.10190723196887538,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3614,0.0678,-22.2419,-7.35582992108177,0.8587627802061572,Pathogenic,0.9977,pathogenic,-4.528,available,https://doi.org/10.1101/2022.10.22.513328 +E198G,NP_000537:p.Glu198Gly,"hg19,17:g.7578256T>C, hg38,17:g.7674938T>C",,,0.915,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1750606,Uncertain significance,2,,,,,1.36516,0.9174089467525482,1.2794766666666666,1.0259817064273482,1.3223183333333333,1.195570853213674,Neutral,Neutral,Neutral,Neutral,Neutral,0.2708515680654342,0.1054189990255815,0.024634919692324057,-0.23217,1.2047633333333334,1.1427540863902388,0.4862966666666667,0.4552920431951194,Neutral,Neutral,Neutral,Neutral,0.4241979704755264,0.23878837742255216,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.2622,0.0678,-6.9542,-3.91981923473022,0.0002448667594076,Benign,0.8918,pathogenic,-3.628,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E198H,NP_000537:p.Glu198His,,,,,saturation_mutlist,,,,,,,,0.75947,0.18856218457221985,,-0.1589060871305333,,0.3002819564347333,,Neutral,Neutral,,Neutral,0.2967208643224629,,0.14162944614167103,0.85297,,-0.06210373612342243,,0.3954331319382888,,Neutral,,Neutral,,0.1240373106806645,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3527,0.0678,-22.2419,-6.97765479253872,0.6099948176751155,Uncertain,0.991,pathogenic,-4.201,available,https://doi.org/10.1101/2022.10.22.513328 +E198I,NP_000537:p.Glu198Ile,,,,,saturation_mutlist,,,,,,,,0.93424,-0.28497302055358886,,-0.11165977807096805,,0.41129011096451595,,Neutral,Neutral,,Neutral,0.5051212245568364,,0.02134319921304678,0.77878,,-0.11490000818045291,,0.3319399959097736,,Neutral,,Neutral,,0.033588417437399445,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3668,0.0678,-22.2419,-6.43304752804169,0.7716709121966066,Pathogenic,0.9911,pathogenic,-4.385,available,https://doi.org/10.1101/2022.10.22.513328 +E198K,NP_000537:p.Glu198Lys,"hg19,17:g.7578257C>T, hg38,17:g.7674939C>T",,,0.910,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.16803,0.38987367153167723,0.16961666666666667,0.26941474821297234,0.16882333333333333,0.21872237410648618,Neutral,Neutral,Neutral,Neutral,Neutral,0.3156669656049952,0.23467516305641622,0.07749220234200394,-0.03094,0.15272000000000002,0.3079615821564532,0.060890000000000014,0.13851079107822659,Neutral,Neutral,Neutral,Neutral,0.30616595641362004,0.1430954200440854,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3364,0.0678,-22.2419,-6.67699439893473,0.5185595493742274,Uncertain,0.9619,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E198L,NP_000537:p.Glu198Leu,,,,,saturation_mutlist,,,,,,,,0.03053,0.06381459593772887,,-0.43339843430424185,,-0.20143421715212093,,Neutral,Neutral,,Neutral,0.29005130092298465,,0.13440162539614692,-0.02376,,-0.43119724326260966,,-0.22747862163130483,,Neutral,,Neutral,,0.12588826536872488,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3689,0.0678,-22.2419,-6.04569525278152,0.3913484744115144,Uncertain,0.9908,pathogenic,-4.132,available,https://doi.org/10.1101/2022.10.22.513328 +E198M,NP_000537:p.Glu198Met,,,,,saturation_mutlist,,,,,,,,0.10057,0.15355921626091004,,-0.07776602980632928,,0.011401985096835363,,Neutral,Neutral,,Neutral,0.24464785354765933,,0.14404367679701924,-0.33552,,-0.13793030437723788,,-0.23672515218861895,,Neutral,,Neutral,,0.182440721002546,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3177,0.0678,-22.2419,-6.29179151053515,0.7448417447284595,Pathogenic,0.9884,pathogenic,-4.399,available,https://doi.org/10.1101/2022.10.22.513328 +E198N,NP_000537:p.Glu198Asn,,,,,saturation_mutlist,,,,,,,,0.56356,0.26512909650802613,,0.15885313335189052,,0.36120656667594525,,Neutral,Neutral,,Neutral,0.2510673301828172,,0.19124019652863258,0.1767,,0.2883349741895022,,0.23251748709475112,,Neutral,,Neutral,,0.21219032442826788,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3406,0.0678,-22.2419,-3.84501911807093,0.5471324505606959,Uncertain,0.9839,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +E198P,NP_000537:p.Glu198Pro,,,,,saturation_mutlist,,,,,,,,3.5628,2.105449385643005,,4.17228026926549,,3.867540134632745,,Destabilizing,Destabilizing,,Destabilizing,0.4643130046672639,,1.070966094408376,1.17577,,3.6967091059546484,,2.436239552977324,,Uncertain,,Uncertain,,1.2264585228363527,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.4714,0.0678,-22.2419,-7.88517255993179,0.546307580719817,Uncertain,0.9952,pathogenic,-4.22,available,https://doi.org/10.1101/2022.10.22.513328 +E198Q,NP_000537:p.Glu198Gln,"hg38,17:g.7674939C>G",,,0.889,"COSMIC,saturation_mutlist",,,,,,,,0.15495,0.1791424858570099,-0.1017,0.28343782046174454,0.026625000000000003,0.21919391023087226,Neutral,Neutral,Neutral,Neutral,Neutral,0.18798298992611484,0.106703900584749,0.05920607600796908,-0.08926,-0.38787,0.22301417338513838,-0.238565,0.06687708669256918,Neutral,Neutral,Neutral,Neutral,0.6488054642700436,0.20816430128392852,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.2869,0.0678,-22.2419,-3.67879250789538,0.0440181537901666,Benign,0.8704,pathogenic,-3.859,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E198R,NP_000537:p.Glu198Arg,,,,,saturation_mutlist,,,,,,,,0.42763,0.32852025508880617,,-0.001111115951938728,,0.21325944202403063,,Neutral,Neutral,,Neutral,0.3064546508938978,,0.11840122940426108,0.25829,,0.04113457047556945,,0.14971228523778474,,Neutral,,Neutral,,0.17498719536209612,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3969,0.0678,-22.2419,-6.11022330690454,0.3099247253021857,Benign,0.9637,pathogenic,-4.328,available,https://doi.org/10.1101/2022.10.22.513328 +E198S,NP_000537:p.Glu198Ser,,,,,saturation_mutlist,,,,,,,,0.50816,0.16699432492256164,,0.5372933849774516,,0.5227266924887257,,Neutral,Neutral,,Neutral,0.21591249984351607,,0.03157586766096202,-0.43625,,0.5771356419501016,,0.07044282097505078,,Neutral,,Neutral,,0.07280473317033473,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3279,0.0678,-22.2419,-5.3672337520513,0.2040811605993631,Benign,0.9341,pathogenic,-3.994,available,https://doi.org/10.1101/2022.10.22.513328 +E198T,NP_000537:p.Glu198Thr,,,,,saturation_mutlist,,,,,,,,0.57448,0.03276236414909364,,0.2879116251295912,,0.43119581256479556,,Neutral,Neutral,,Neutral,0.2008431676274196,,0.060133776929492386,0.70186,,0.43278448508032824,,0.5673222425401642,,Neutral,,Neutral,,0.07109254715343029,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3438,0.0678,-22.2419,-6.09562816383539,0.5761769011089655,Uncertain,0.9712,pathogenic,-4.117,available,https://doi.org/10.1101/2022.10.22.513328 +E198V,NP_000537:p.Glu198Val,"hg38,17:g.7674938T>A",,,0.926,"COSMIC,saturation_mutlist",,,,,,,,1.09761,-0.28718783617019655,0.07879666666666663,-0.0249412234971996,0.5882033333333333,0.5363343882514002,Neutral,Neutral,Neutral,Neutral,Neutral,0.44924475835968253,0.462868704662084,0.07848578331450014,0.59747,-0.5312933333333333,0.05033006832366049,0.03308833333333333,0.3239000341618302,Neutral,Neutral,Neutral,Neutral,0.4055443204166744,0.08072790911327231,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,uncertain,,-0.3277,0.0678,-22.2419,-6.1303990407713,0.4552757701320393,Uncertain,0.9698,pathogenic,-4.025,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E198W,NP_000537:p.Glu198Trp,,,,,saturation_mutlist,,,,,,,,0.25025,0.2899395823478699,,-0.6925097584770175,,-0.22112987923850874,,Neutral,Neutral,,Neutral,0.28597273139750673,,0.14819641302197456,0.69431,,-0.6385315156761976,,0.027889242161901195,,Neutral,,Neutral,,0.11227663179456689,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3715,0.0678,-22.2419,-7.35582992108177,0.856607791247208,Pathogenic,0.9988,pathogenic,-4.755,available,https://doi.org/10.1101/2022.10.22.513328 +E198Y,NP_000537:p.Glu198Tyr,,,,,saturation_mutlist,,,,,,,,0.09581,0.16125723004341125,,-0.193145100502627,,-0.0486675502513135,,Neutral,Neutral,,Neutral,0.37748107316821916,,0.1496541393345944,0.01857,,-0.14054880467776032,,-0.06098940233888016,,Neutral,,Neutral,,0.10501051089280088,51.209,6.281,48.68,9.83,,False,51.209,,neutral,neutral,neutral,,False,48.68,,neutral,neutral,neutral,damaging,,-0.3623,0.0678,-22.2419,-7.35582992108177,0.8565579991117023,Pathogenic,0.9964,pathogenic,-4.578,available,https://doi.org/10.1101/2022.10.22.513328 +G199A,NP_000537:p.Gly199Ala,"hg38,17:g.7674935C>G",,,0.888,"COSMIC,saturation_mutlist",,,,,,,,3.1295,1.2603670692443847,1.03118,1.5994141749259807,2.08034,2.3644570874629904,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.13547901660603376,0.14520540233292517,0.268050236375153,1.69042,1.4677999999999998,1.6144013845125504,1.57911,1.6524106922562751,Neutral,Neutral,Neutral,Neutral,0.18716864694707822,0.3291751025142916,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.2948,0.1416,-7.3721,-4.80334672416214,6.86442044252819e-05,Benign,0.7779,pathogenic,-3.74,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G199C,NP_000537:p.Gly199Cys,,,,,saturation_mutlist,,,,,,,,3.11836,0.6399662899971008,,1.92919634598773,,2.523778172993865,,Uncertain,Neutral,,Uncertain,0.12794398719055303,,0.20955866212248989,2.03683,,1.974140929045144,,2.005485464522572,,Uncertain,,Uncertain,,0.3149656904594339,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4304,0.1416,-22.2448,-6.8709400035319,0.5037951790693465,Uncertain,0.9256,pathogenic,-4.322,available,https://doi.org/10.1101/2022.10.22.513328 +G199D,NP_000537:p.Gly199Asp,,,,,saturation_mutlist,,,,,,,,3.33413,1.1909267449378966,,0.9661237930578265,,2.150126896528913,,Uncertain,Uncertain,,Uncertain,0.162525759196826,,0.25944446648132313,1.92626,,1.0136054477464098,,1.469932723873205,,Neutral,,Neutral,,0.35758239719245677,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4309,0.1416,-22.2448,-6.05306704732168,0.1733264526690307,Benign,0.9505,pathogenic,-4.043,available,https://doi.org/10.1101/2022.10.22.513328 +G199E,NP_000537:p.Gly199Glu,"hg19,17:g.7578253C>T, hg19,17:g.7674935C>T, hg38,17:g.7674935C>T",,,0.880,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",582257,Uncertain significance,2,,,,,3.42398,1.2591005730628968,0.9746033333333334,1.3265769916509835,2.1992916666666664,2.3752784958254916,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.1523431369030276,0.05062431716960625,0.2730759538810491,2.11956,1.0077066666666665,1.4255689366099895,1.5636333333333332,1.7725644683049948,Uncertain,Uncertain,Neutral,Neutral,0.2161720522073923,0.4691085155786694,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.3522,0.1416,-6.9571,-3.96135340166989,0.0299906564285995,Benign,0.9647,pathogenic,-3.885,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G199F,NP_000537:p.Gly199Phe,,,,,saturation_mutlist,,,,,,,,2.93102,1.1235298109054566,,1.0356261324570761,,1.9833230662285382,,Uncertain,Uncertain,,Neutral,0.15029518355199398,,0.12557183783503847,2.0562,,1.1312762548996624,,1.5937381274498312,,Uncertain,,Neutral,,0.38987494100400455,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4685,0.1416,-22.2448,-5.88443302893061,0.848709424045369,Pathogenic,0.9939,pathogenic,-4.687,available,https://doi.org/10.1101/2022.10.22.513328 +G199H,NP_000537:p.Gly199His,,,,,saturation_mutlist,,,,,,,,3.38307,1.0869832468032836,,0.7961189900741891,,2.0895944950370944,,Uncertain,Uncertain,,Uncertain,0.14528038919899838,,0.2792614887281673,2.15565,,0.7671469810721411,,1.4613984905360706,,Uncertain,,Neutral,,0.2563072502669089,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4432,0.1416,-22.2448,-4.69049149783605,0.0537274039140483,Benign,0.9886,pathogenic,-4.295,available,https://doi.org/10.1101/2022.10.22.513328 +G199I,NP_000537:p.Gly199Ile,"hg19,17:g.7578253_7578254delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,4.51608,1.6673698902130127,4.058166666666667,2.497306855596833,4.287123333333334,3.5066934277984165,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.2060130257714334,0.7054692368598049,0.16904086485180744,3.49076,4.5526100000000005,2.7656725700116596,4.021685,3.1282162850058297,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.5391837583483636,0.47430236775334483,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.5142,0.1416,-22.2448,-7.38569882570294,0.8509103896318686,Pathogenic,0.9905,pathogenic,-4.673,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G199K,NP_000537:p.Gly199Lys,,,,,saturation_mutlist,,,,,,,,2.85265,1.3333647990226745,0.5980733333333333,0.9723591606823021,1.7253616666666667,1.9125045803411511,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.15345064887525506,0.44641919943280023,0.2540745028997042,1.75774,0.23582999999999998,1.0234815402049746,0.996785,1.3906107701024872,Neutral,Neutral,Neutral,Neutral,0.5212557454839227,0.36062115367488223,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4632,0.1416,-22.2448,-7.64307823678845,0.7976349428260668,Pathogenic,0.9923,pathogenic,-4.393,available,https://doi.org/10.1101/2022.10.22.513328 +G199L,NP_000537:p.Gly199Leu,,,,,saturation_mutlist,,,,,,,,2.94178,1.24735276222229,,1.0733515412351302,,2.007565770617565,,Uncertain,Uncertain,,Uncertain,0.1545356085687247,,0.23034215554463336,2.14204,,1.1367560523914786,,1.6393980261957393,,Uncertain,,Neutral,,0.42536996799382315,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4824,0.1416,-22.2448,-7.38569882570294,0.7892289216637154,Pathogenic,0.9872,pathogenic,-4.56,available,https://doi.org/10.1101/2022.10.22.513328 +G199M,NP_000537:p.Gly199Met,,,,,saturation_mutlist,,,,,,,,2.89945,1.1915748739242553,,1.2060275749268163,,2.052738787463408,,Uncertain,Uncertain,,Uncertain,0.15990694701690963,,0.18208347297745447,2.07561,,1.210016172639094,,1.642813086319547,,Uncertain,,Neutral,,0.2883310049020893,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4206,0.1416,-22.2448,-7.38569882570294,0.728915006186129,Pathogenic,0.9883,pathogenic,-4.59,available,https://doi.org/10.1101/2022.10.22.513328 +G199N,NP_000537:p.Gly199Asn,,,,,saturation_mutlist,,,,,,,,2.73381,0.9624584841728211,,0.7125887994488288,,1.7231993997244144,,Uncertain,Neutral,,Neutral,0.20575213138920068,,0.3342616129711826,1.81014,,0.5695178679114067,,1.1898289339557033,,Neutral,,Neutral,,0.32048250690830826,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4312,0.1416,-22.2448,-6.3901912466579,0.5371317316087846,Uncertain,0.9299,pathogenic,-4.014,available,https://doi.org/10.1101/2022.10.22.513328 +G199P,NP_000537:p.Gly199Pro,,,,,saturation_mutlist,,,,,,,,7.18143,1.889001154899597,,6.816297578716067,,6.998863789358033,,Destabilizing,Uncertain,,Destabilizing,0.19585917768873146,,0.9135890187017034,5.79878,,6.9275834938526275,,6.363181746926314,,Destabilizing,,Destabilizing,,0.8754960399667538,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.5283,0.1416,-22.2448,-6.67581907822099,0.811693595457798,Pathogenic,0.9976,pathogenic,-4.455,available,https://doi.org/10.1101/2022.10.22.513328 +G199Q,NP_000537:p.Gly199Gln,,,,,saturation_mutlist,,,,,,,,3.06363,1.3056773519515992,,1.3257692882382286,,2.1946996441191144,,Uncertain,Uncertain,,Uncertain,0.1517316869226139,,0.28019299632249567,1.88599,,1.3738802775346828,,1.6299351387673413,,Neutral,,Neutral,,0.4071052876536379,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4341,0.1416,-22.2448,-6.54974915504437,0.5479391245755375,Uncertain,0.9798,pathogenic,-4.363,available,https://doi.org/10.1101/2022.10.22.513328 +G199R,NP_000537:p.Gly199Arg,"hg19,17:g.7578254C>T, hg38,17:g.7674936C>T",,,0.883,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1015039,Uncertain significance,2,,,,,3.17836,1.3296250867843629,1.1175733333333333,0.8497832248324378,2.1479666666666666,2.014071612416219,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.13926850186877301,0.17267272363893751,0.2616661651232659,1.81256,0.9055566666666667,0.8925862955192759,1.3590583333333333,1.3525731477596379,Neutral,Neutral,Neutral,Neutral,0.49997298689251424,0.3286741751238919,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.3794,0.1416,-8.957,-7.64307823678845,0.8380371354316876,Pathogenic,0.9824,pathogenic,-4.342,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G199S,NP_000537:p.Gly199Ser,,,,,saturation_mutlist,,,,,,,,3.64795,1.307701756954193,,1.4357070886521395,,2.5418285443260697,,Uncertain,Uncertain,,Uncertain,0.1353738688516283,,0.19130494203793075,1.86974,,1.4890836250059831,,1.6794118125029915,,Neutral,,Neutral,,0.21788911443720257,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.3766,0.1416,-22.2448,-6.02974354335764,0.2749630817254707,Benign,0.7501,pathogenic,-4.172,available,https://doi.org/10.1101/2022.10.22.513328 +G199T,NP_000537:p.Gly199Thr,"hg38,17:g.7674935_7674936delinsGT",,,,"COSMIC,saturation_mutlist",,,,,,,,4.54587,1.5105990529060365,1.10839,2.211251964068602,2.82713,3.378560982034301,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,0.20822118314739443,0.009052782261087779,0.24198701190586663,2.92646,1.8280066666666668,2.335709314762776,2.3772333333333333,2.631084657381388,Uncertain,Uncertain,Uncertain,Uncertain,0.05155144507081144,0.2806707345392568,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4535,0.1416,-22.2448,-6.8709400035319,0.8369289085395977,Pathogenic,0.9385,pathogenic,-4.364,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G199V,NP_000537:p.Gly199Val,"hg19,17:g.7578253C>A, hg19,17:g.7674935C>A, hg38,17:g.7674935C>A",,,0.899,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",451799,Likely pathogenic,1,,,Tier I - Strong,1,4.77329,1.6627264547348022,4.115646666666667,2.3371410468229796,4.444468333333333,3.5552155234114897,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.19181973556230278,0.5765576277836896,0.07632490405077397,3.22483,4.8086166666666665,2.5410559790364533,4.016723333333333,2.8829429895182264,Destabilizing,Uncertain,Destabilizing,Uncertain,0.3401864831072642,0.38250814879096195,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4574,0.1416,-22.2448,-7.38569882570294,0.8217192873988828,Pathogenic,0.9687,pathogenic,-4.576,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G199W,NP_000537:p.Gly199Trp,,,,,saturation_mutlist,,,,,,,,3.32933,1.3242504739761352,,0.8668941925068877,,2.098112096253444,,Uncertain,Uncertain,,Uncertain,0.1447517551323956,,0.16419165008365777,2.28376,,0.9729667118389175,,1.6283633559194588,,Uncertain,,Neutral,,0.34843780636945576,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4683,0.1416,-22.2448,-5.88443302893061,0.8335051489904379,Pathogenic,0.9862,pathogenic,-4.64,available,https://doi.org/10.1101/2022.10.22.513328 +G199Y,NP_000537:p.Gly199Tyr,,,,,saturation_mutlist,,,,,,,,3.07198,1.2021819376945495,,1.1282256024234139,,2.100102801211707,,Uncertain,Uncertain,,Uncertain,0.13689764809733207,,0.14160763543198002,2.13426,,1.1881223751791026,,1.661191187589551,,Uncertain,,Neutral,,0.359144211051491,88.939,8.199,109.395,14.62,,False,88.939,,neutral,neutral,neutral,,False,109.395,,neutral,neutral,neutral,uncertain,,-0.4689,0.1416,-22.2448,-5.88443302893061,0.7942430489742779,Pathogenic,0.9849,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328 +N200A,NP_000537:p.Asn200Ala,,,,,saturation_mutlist,,,,,,,,0.38181,0.4310070836544037,,0.9280759171573442,,0.6549429585786721,,Neutral,Neutral,,Neutral,0.5388795875634379,,0.3847965956441937,-1.14538,,0.6354548734764717,,-0.2549625632617642,,Neutral,,Neutral,,0.27767479452167354,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.2718,0.6214,-22.2448,-4.70606374613329,0.7178942931373743,Pathogenic,0.8658,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328 +N200C,NP_000537:p.Asn200Cys,,,,,saturation_mutlist,,,,,,,,-0.05327,-0.15054407358169555,,1.1557683334595255,,0.5512491667297628,,Neutral,Neutral,,Neutral,0.3745874422575333,,0.23714694666194866,-1.04345,,1.002095823927342,,-0.02067708803632895,,Neutral,,Neutral,,0.32751161839122167,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.2538,0.6214,-8.957,-3.38068171152327,0.0182571053610159,Benign,0.5899,pathogenic,-3.72,available,https://doi.org/10.1101/2022.10.22.513328 +N200D,NP_000537:p.Asn200Asp,"hg19,17:g.7578251T>C, hg38,17:g.7674933T>C",,,0.840,"COSMIC,ClinVar,saturation_mutlist",1061739,Uncertain significance,2,,,,,0.53786,0.1765490122139454,-0.7545333333333334,1.0512005713364505,-0.10833666666666669,0.7945302856682253,Neutral,Neutral,Neutral,Neutral,Neutral,0.3093002966852779,0.7887914101262062,0.3965825395318023,-0.12573,0.5657633333333334,1.7211505896668235,0.2200166666666667,0.7977102948334118,Neutral,Neutral,Neutral,Neutral,1.128883610455726,0.9782564637558918,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,uncertain,,-0.275,0.6214,-22.2448,-3.29350549214925,0.6650299812568407,Uncertain,0.7248,pathogenic,-3.643,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N200E,NP_000537:p.Asn200Glu,,,,,saturation_mutlist,,,,,,,,0.18083,0.3599861776828766,,0.9986880990868872,,0.5897590495434436,,Neutral,Neutral,,Neutral,0.6434891193575346,,0.46946748414021217,0.46041,,1.612546568414877,,1.0364782842074385,,Neutral,,Neutral,,0.8863091384376338,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.3021,0.6214,-22.2448,-3.27573005752842,0.2038018284710903,Benign,0.963,pathogenic,-3.962,available,https://doi.org/10.1101/2022.10.22.513328 +N200F,NP_000537:p.Asn200Phe,,,,,saturation_mutlist,,,,,,,,-1.50744,0.015857665538787855,,-0.5109173633427667,,-1.0091786816713832,,Neutral,Neutral,,Neutral,0.682546987918481,,0.07551082702918992,3.18351,,0.31494833495635344,,1.7492291674781768,,Uncertain,,Neutral,,0.9627168246840478,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.256,0.6214,-7.957,-3.80485558407959,0.6461120110354758,Uncertain,0.954,pathogenic,-4.016,available,https://doi.org/10.1101/2022.10.22.513328 +N200G,NP_000537:p.Asn200Gly,,,,,saturation_mutlist,,,,,,,,1.53057,1.0106823843717576,,1.9690601303659323,,1.749815065182966,,Neutral,Uncertain,,Neutral,0.5387090941419881,,0.4632899979973295,-1.9546,,1.988269873164733,,0.016834936582366566,,Neutral,,Neutral,,0.8364126323208557,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.2347,0.6214,-8.957,-6.18601377560582,0.068765973426231,Benign,0.8668,pathogenic,-3.796,available,https://doi.org/10.1101/2022.10.22.513328 +N200H,NP_000537:p.Asn200His,"hg19,17:g.7578251T>G, hg38,17:g.7674933T>G",,,0.850,"ClinVar,saturation_mutlist",2006345,Uncertain significance,1,,,,,-0.17016,-0.08861180424690246,0.4426333333333334,0.1021533423938355,0.13623666666666667,-0.03400332880308225,Neutral,Neutral,Neutral,Neutral,Neutral,0.44049681868434276,0.9354796119757085,0.15531024123487905,3.93677,2.0273233333333334,0.8022666173706122,2.9820466666666667,2.369518308685306,Uncertain,Uncertain,Uncertain,Uncertain,1.233420690095458,0.6780472535836787,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.2767,0.6214,-22.2448,-4.73925841340621,0.3629318295858595,Uncertain,0.5591,ambiguous,-3.619,available,https://doi.org/10.1101/2022.10.22.513328 +N200I,NP_000537:p.Asn200Ile,"hg38,17:g.7674932T>A",,,0.792,"COSMIC,saturation_mutlist",,,,,,,,-0.94548,0.19282761931419373,-0.24433333333333337,-0.14937874371953777,-0.5949066666666667,-0.5474293718597689,Neutral,Neutral,Neutral,Neutral,Neutral,0.426694683833532,0.690803184191336,0.43384916530800893,0.94288,-0.027889999999999988,0.3297749692013276,0.45749500000000004,0.6363274846006638,Neutral,Neutral,Neutral,Neutral,0.19470747614477127,0.30541173585863535,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.2461,0.6214,-7.3721,-3.88280033074422,0.0021322772332192,Benign,0.8104,pathogenic,-3.804,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N200K,NP_000537:p.Asn200Lys,,,,,saturation_mutlist,,,,,,,,-0.75236,0.7647593432664871,1.31349,1.1289419282301052,0.280565,0.18829096411505258,Neutral,Neutral,Neutral,Neutral,Neutral,0.5367290045341157,0.45089511470703103,0.6060281871181175,0.2835,2.144556666666667,1.9409660469929972,1.2140283333333335,1.1122330234964986,Uncertain,Neutral,Neutral,Neutral,2.7596563350332026,0.9712853376627301,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.275,0.6214,-22.2448,-4.36009452915514,0.5441893776244784,Uncertain,0.9759,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +N200L,NP_000537:p.Asn200Leu,,,,,saturation_mutlist,,,,,,,,-1.30023,-0.00706925988197327,,-0.5150324115303478,,-0.9076312057651739,,Neutral,Neutral,,Neutral,0.4243981831699278,,0.219149753276893,0.01118,,-0.10233341734527895,,-0.04557670867263948,,Neutral,,Neutral,,0.2963659370707757,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.3284,0.6214,-22.2448,-6.17706167855285,0.5522632701308042,Uncertain,0.8329,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328 +N200M,NP_000537:p.Asn200Met,,,,,saturation_mutlist,,,,,,,,-1.74943,-0.017182109355926515,,-0.06917219352861326,,-0.9093010967643067,,Neutral,Neutral,,Neutral,0.5369525165286051,,0.11936352590450051,-0.84979,,0.26345681550316374,,-0.2931665922484181,,Neutral,,Neutral,,0.2550527993609525,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.2826,0.6214,-22.2448,-6.17706167855285,0.4474937082728807,Uncertain,0.8712,pathogenic,-4.194,available,https://doi.org/10.1101/2022.10.22.513328 +N200P,NP_000537:p.Asn200Pro,,,,,saturation_mutlist,,,,,,,,3.10278,1.5485175842046737,,4.287411402647781,,3.6950957013238908,,Destabilizing,Uncertain,,Destabilizing,0.6662997304585375,,1.68555696504109,1.61142,,5.0392973904972775,,3.3253586952486387,,Uncertain,,Destabilizing,,1.2331136084075263,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,uncertain,,-0.4374,0.6214,-22.2448,-6.87159515347392,0.3437941992529058,Uncertain,0.9559,pathogenic,-4.11,available,https://doi.org/10.1101/2022.10.22.513328 +N200Q,NP_000537:p.Asn200Gln,,,,,saturation_mutlist,,,,,,,,-0.30398,0.24950413703918456,,0.7713284580041292,,0.2336742290020646,,Neutral,Neutral,,Neutral,0.536679264672868,,0.3252048945444345,-0.03645,,1.0308862995915546,,0.49721814979577733,,Neutral,,Neutral,,0.3274249068522609,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.2657,0.6214,-22.2448,-3.75604555492313,0.7776234660143829,Pathogenic,0.9355,pathogenic,-3.86,available,https://doi.org/10.1101/2022.10.22.513328 +N200R,NP_000537:p.Asn200Arg,,,,,saturation_mutlist,,,,,,,,-0.76894,0.686632239818573,,0.4514253195144224,,-0.15875734024278879,,Neutral,Neutral,,Neutral,0.5652593575245535,,0.3894470442542304,0.94713,,1.2001781026749638,,1.073654051337482,,Neutral,,Neutral,,0.5500682486246184,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.3071,0.6214,-22.2448,-4.97345972867756,0.5955775745557251,Uncertain,0.9725,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328 +N200S,NP_000537:p.Asn200Ser,"hg19,17:g.7578250T>C, hg38,17:g.7674932T>C",,,0.678,"COSMIC,ClinVar,saturation_mutlist",924379,Uncertain significance,1,,,,,0.66723,0.3267503666877747,1.79898,1.2760812792068212,1.2331050000000001,0.9716556396034106,Neutral,Neutral,Neutral,Neutral,Neutral,0.34313246712978757,0.5159181219922402,0.46507303068995975,-1.06572,0.38299,1.2764396127984678,-0.34136500000000003,0.10535980639923392,Neutral,Neutral,Neutral,Neutral,0.26830702649514543,0.5702446891709357,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.1458,0.6214,-3.4653,-2.69652319272738,3.4334945744070325e-05,Benign,0.2322,benign,-3.204,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N200T,NP_000537:p.Asn200Thr,"hg38,17:g.7674932T>G",,,0.768,"COSMIC,saturation_mutlist",,,,,,,,0.052,0.5686871218681335,1.4716566666666668,0.9240371733705479,0.7618283333333334,0.488018586685274,Neutral,Neutral,Neutral,Neutral,Neutral,0.5565875734000771,0.42978619462342993,0.5073985385853382,-0.11032,-0.8028333333333334,0.9799996871790814,-0.4565766666666667,0.4348398435895407,Neutral,Neutral,Neutral,Neutral,0.8207661695973801,0.34353823767382874,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,uncertain,,-0.2153,0.6214,-7.3721,-2.68225003822747,0.0018563863109407,Benign,0.6728,pathogenic,-3.621,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N200V,NP_000537:p.Asn200Val,,,,,saturation_mutlist,,,,,,,,-0.52834,0.16165525555610658,,0.07308524301400839,,-0.22762737849299583,,Neutral,Neutral,,Neutral,0.47265066873832057,,0.44233731474827537,0.11115,,0.2872414679815425,,0.19919573399077123,,Neutral,,Neutral,,0.2860833489019926,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.3154,0.6214,-22.2448,-5.93954811469127,0.4932106671626945,Uncertain,0.8136,pathogenic,-3.994,available,https://doi.org/10.1101/2022.10.22.513328 +N200W,NP_000537:p.Asn200Trp,,,,,saturation_mutlist,,,,,,,,-1.17858,0.045018310546875,,-0.506229865415048,,-0.842404932707524,,Neutral,Neutral,,Neutral,0.5210005497173699,,0.08651565668744672,6.83947,,0.6237474520946434,,3.731608726047322,,Uncertain,,Destabilizing,,1.046976886263574,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.334,0.6214,-22.2448,-5.66554857065075,0.6537730166788992,Uncertain,0.9867,pathogenic,-4.468,available,https://doi.org/10.1101/2022.10.22.513328 +N200Y,NP_000537:p.Asn200Tyr,"hg19,17:g.7578251T>A, hg38,17:g.7674933T>A",,,0.900,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2450739,Uncertain significance,1,,,,,-1.20146,-0.011424121856689453,-0.7140599999999999,-0.20019134395602708,-0.95776,-0.7008256719780135,Neutral,Neutral,Neutral,Neutral,Neutral,0.6913477029057798,1.2333619965768363,0.08676487814780767,4.28151,2.49263,0.7830115953121668,3.38707,2.5322607976560834,Uncertain,Uncertain,Destabilizing,Uncertain,2.5551573296765895,1.0709824441741762,29.988,7.62,33.855,26.157,,False,29.988,,neutral,neutral,neutral,,False,33.855,,neutral,neutral,neutral,damaging,,-0.3125,0.6214,-22.2448,-5.66554857065075,0.7598088753886141,Pathogenic,0.7838,pathogenic,-4.262,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L201A,NP_000537:p.Leu201Ala,,,,,saturation_mutlist,,,,,,,,0.22522,0.015633733272552484,,0.7909074964161595,,0.5080637482080798,,Neutral,Neutral,,Neutral,0.10400789531081193,,0.2793105892177556,0.15393,,1.5785605723556422,,0.8662452861778211,,Neutral,,Neutral,,0.18536193152609032,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.142,2.2788,-8.957,-2.40647612735403,0.0001166967365213,Benign,0.1339,benign,-3.321,available,https://doi.org/10.1101/2022.10.22.513328 +L201C,NP_000537:p.Leu201Cys,,,,,saturation_mutlist,,,,,,,,0.67592,-0.17843704462051388,,1.2540496357117945,,0.9649848178558973,,Neutral,Neutral,,Neutral,0.04348997631091189,,0.14508797666620504,0.49015,,1.9540086167741328,,1.2220793083870665,,Neutral,,Neutral,,0.038881348042222943,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.1262,2.2788,-7.957,-1.15700260055409,0.0172092318306046,Benign,0.3744,ambiguous,-3.562,available,https://doi.org/10.1101/2022.10.22.513328 +L201D,NP_000537:p.Leu201Asp,,,,,saturation_mutlist,,,,,,,,0.06691,-0.026629018783569332,,0.4193433758617143,,0.24312668793085712,,Neutral,Neutral,,Neutral,0.1301873525088499,,0.21695716338689242,1.4124,,1.8667014486022302,,1.6395507243011151,,Neutral,,Neutral,,0.29373506006228356,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.3314,2.2788,-22.2448,-2.55040462010664,0.0045385808441924,Benign,0.4619,ambiguous,-3.641,available,https://doi.org/10.1101/2022.10.22.513328 +L201E,NP_000537:p.Leu201Glu,,,,,saturation_mutlist,,,,,,,,0.02384,0.035670049190521226,,0.4622421300718973,,0.24304106503594863,,Neutral,Neutral,,Neutral,0.12455442087545576,,0.24271644815823312,1.20787,,1.5977019062173186,,1.4027859531086593,,Neutral,,Neutral,,0.26664883478489576,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.2265,2.2788,-7.957,-1.62484319601199,0.0006284759351469,Benign,0.2412,benign,-3.45,available,https://doi.org/10.1101/2022.10.22.513328 +L201F,NP_000537:p.Leu201Phe,"hg38,17:g.7674928C>A, hg38,17:g.7674928C>G",,,0.446,"COSMIC,saturation_mutlist",,,,,,,,0.04449,0.032579586505889886,-0.017686666666666667,0.3222806074904235,0.013401666666666668,0.18338530374521173,Neutral,Neutral,Neutral,Neutral,Neutral,0.11593805592756322,0.2707433846939858,0.12255169017844618,1.64017,-0.1286866666666667,0.6802754884190122,0.7557416666666666,1.160222744209506,Neutral,Neutral,Neutral,Neutral,0.5553316832508498,0.23081906493379584,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.0704,2.2788,-7.957,-3.07549202194472,0.004922315040853,Benign,0.1485,benign,-3.371,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L201G,NP_000537:p.Leu201Gly,,,,,saturation_mutlist,,,,,,,,0.18543,0.3329290044307709,,1.1622134189744904,,0.6738217094872452,,Neutral,Neutral,,Neutral,0.16198929906257753,,0.29214057307680874,-0.1498,,2.510807585190602,,1.180503792595301,,Uncertain,,Neutral,,0.21856710433291154,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.2847,2.2788,-22.2448,-5.2755006118749,0.0059431267745625,Benign,0.2483,benign,-3.584,available,https://doi.org/10.1101/2022.10.22.513328 +L201H,NP_000537:p.Leu201His,,,,,saturation_mutlist,,,,,,,,0.26357,0.03381056547164914,,0.20860154346173512,,0.2360857717308676,,Neutral,Neutral,,Neutral,0.0384677520485959,,0.11433614878416193,2.11608,,1.0683332768749887,,1.5922066384374944,,Uncertain,,Neutral,,0.0963875277525875,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.1793,2.2788,-7.957,-2.51710073751225,7.272533883244776e-05,Benign,0.175,benign,-3.244,available,https://doi.org/10.1101/2022.10.22.513328 +L201I,NP_000537:p.Leu201Ile,,,,,saturation_mutlist,,,,,,,,0.25636,-0.019479165077209478,,0.5821229785728653,,0.4192414892864327,,Neutral,Neutral,,Neutral,0.08756558807498284,,0.13631980921999073,1.76793,,0.8247633272471878,,1.2963466636235939,,Neutral,,Neutral,,0.11716099155360603,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.084,2.2788,-22.2448,-3.32346447203425,0.0151393179595806,Benign,0.1171,benign,-3.426,available,https://doi.org/10.1101/2022.10.22.513328 +L201K,NP_000537:p.Leu201Lys,,,,,saturation_mutlist,,,,,,,,-0.02276,0.0826100730895996,,0.5303319445308364,,0.2537859722654182,,Neutral,Neutral,,Neutral,0.10854202765462083,,0.2041726092028639,0.80016,,1.3806860427079448,,1.0904230213539723,,Neutral,,Neutral,,0.1290116890841128,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.2984,2.2788,-22.2448,-4.34109503692497,6.954692770157944e-05,Benign,0.2691,benign,-3.55,available,https://doi.org/10.1101/2022.10.22.513328 +L201M,NP_000537:p.Leu201Met,"hg19,17:g.7578248A>T, hg38,17:g.7674930A>T",,,0.485,"ClinVar,saturation_mutlist",1751128,Uncertain significance,1,,,,,0.46076,0.08265141963958739,0.26496666666666663,0.4677822330544363,0.3628633333333333,0.46427111652721814,Neutral,Neutral,Neutral,Neutral,Neutral,0.03223524911534983,0.18931445627726257,0.09799533443986495,0.03369,0.3098633333333333,0.7985444070092114,0.17177666666666666,0.4161172035046057,Neutral,Neutral,Neutral,Neutral,0.2347615048417341,0.12203320541500644,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.0314,2.2788,-7.3721,-0.566286831019014,8.739344011707353e-05,Benign,0.0943,benign,-3.219,available,https://doi.org/10.1101/2022.10.22.513328 +L201N,NP_000537:p.Leu201Asn,,,,,saturation_mutlist,,,,,,,,0.16883,0.08805608749389644,,0.4182065606392002,,0.2935182803196001,,Neutral,Neutral,,Neutral,0.07907744142501116,,0.1580875132723016,0.70283,,1.3703598937276291,,1.0365949468638145,,Neutral,,Neutral,,0.11064722729720632,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.1768,2.2788,-2.4814,-1.69931918644977,0.0001308633320518,Benign,0.2196,benign,-3.346,available,https://doi.org/10.1101/2022.10.22.513328 +L201P,NP_000537:p.Leu201Pro,"hg38,17:g.7674929_7674930delinsGG",,,,"COSMIC,saturation_mutlist",,,,,,,,0.16526,0.20920449614524841,0.2227866666666667,1.7508036684363992,0.19402333333333333,0.9580318342181996,Neutral,Neutral,Neutral,Neutral,Neutral,0.3271643026100926,0.3614931328378022,0.5633601335084211,0.84824,4.090703333333333,5.644205509204215,2.4694716666666663,3.2462227546021074,Uncertain,Uncertain,Uncertain,Destabilizing,2.1311358979557253,0.40925419087233583,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.2038,2.2788,-4.7092,-0.722144173015352,8.045290590727062e-09,Benign,0.0876,benign,-3.162,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L201Q,NP_000537:p.Leu201Gln,,,,,saturation_mutlist,,,,,,,,0.01223,0.04526449918746947,,0.6690720517899212,,0.3406510258949606,,Neutral,Neutral,,Neutral,0.09010091013126767,,0.14350873602533287,0.76306,,1.3718448532705259,,1.067452426635263,,Neutral,,Neutral,,0.13457877314982394,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.1316,2.2788,-2.8486,-0.807299698791689,9.279905668473807e-08,Benign,0.0982,benign,-3.025,available,https://doi.org/10.1101/2022.10.22.513328 +L201R,NP_000537:p.Leu201Arg,,,,,saturation_mutlist,,,,,,,,0.04473,0.07748380422592162,,0.38298829283713137,,0.21385914641856568,,Neutral,Neutral,,Neutral,0.11128412665145204,,0.1712675365650153,1.0846,,0.960123574480698,,1.022361787240349,,Neutral,,Neutral,,0.07085176363363324,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.2222,2.2788,-8.957,-2.50036232905976,0.0002867534106675,Benign,0.1793,benign,-3.396,available,https://doi.org/10.1101/2022.10.22.513328 +L201S,NP_000537:p.Leu201Ser,"hg38,17:g.7674929A>G",,,0.505,"COSMIC,saturation_mutlist",,,,,,,,0.23622,-0.08519829034805294,0.05634999999999999,0.6708262597101653,0.146285,0.45352312985508264,Neutral,Neutral,Neutral,Neutral,Neutral,0.101615076218774,0.1756014174202475,0.27278814663641016,0.75264,1.03957,1.9903446939467848,0.896105,1.3714923469733924,Neutral,Neutral,Neutral,Neutral,0.3750250157878361,0.19537899270051304,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.1331,2.2788,-1.2567,-0.196241491882778,3.9402182750519955e-09,Benign,0.1323,benign,-2.974,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L201T,NP_000537:p.Leu201Thr,,,,,saturation_mutlist,,,,,,,,0.22308,-0.0950545835494995,,0.6564355940503054,,0.4397577970251527,,Neutral,Neutral,,Neutral,0.07935954679491322,,0.23942741516944452,1.87297,,1.6685759989559894,,1.7707729994779946,,Neutral,,Neutral,,0.09758819064027531,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.1401,2.2788,-7.957,-1.5589299240126,3.104088341486957e-05,Benign,0.1305,benign,-3.25,available,https://doi.org/10.1101/2022.10.22.513328 +L201V,NP_000537:p.Leu201Val,"hg38,17:g.7674930A>C",,,0.447,"COSMIC,saturation_mutlist",,,,,,,,0.32741,0.019512963294982897,0.44671,0.6176118526023759,0.38705999999999996,0.47251092630118796,Neutral,Neutral,Neutral,Neutral,Neutral,0.0819048413172992,0.35203051468113766,0.13315250455326336,1.46109,0.9017,1.0347570950675051,1.181395,1.2479235475337527,Neutral,Neutral,Neutral,Neutral,0.746891087419489,0.1871108558075071,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.0524,2.2788,-8.957,-2.17201643401262,0.0025459696746585,Benign,0.0939,benign,-3.244,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L201W,NP_000537:p.Leu201Trp,,,,,saturation_mutlist,,,,,,,,0.1093,-0.13049907207489012,,0.026956466972294164,,0.06812823348614708,,Neutral,Neutral,,Neutral,0.15009690999137532,,0.06759351005749138,2.97146,,0.45163810856314973,,1.7115490542815748,,Uncertain,,Neutral,,0.22634162797956678,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.2425,2.2788,-22.2448,-4.53905235236055,0.4061847922828556,Uncertain,0.2357,benign,-3.904,available,https://doi.org/10.1101/2022.10.22.513328 +L201Y,NP_000537:p.Leu201Tyr,,,,,saturation_mutlist,,,,,,,,0.0662,-0.01698311686515808,,0.33226938053684724,,0.1992346902684236,,Neutral,Neutral,,Neutral,0.12826656425838132,,0.0930495318413476,3.15487,,0.8565169807591041,,2.005693490379552,,Uncertain,,Uncertain,,0.21320407769225996,90.144,8.32,30.64,19.656,,False,90.144,,neutral,neutral,neutral,,False,30.64,,neutral,neutral,neutral,uncertain,,-0.1675,2.2788,-8.957,-4.53905235236055,0.0078126119531683,Benign,0.3429,ambiguous,-3.489,available,https://doi.org/10.1101/2022.10.22.513328 +R202A,NP_000537:p.Arg202Ala,,,,,saturation_mutlist,,,,,,,,0.51734,0.26385464072227477,,0.5539709525790822,,0.5356554762895411,,Neutral,Neutral,,Neutral,0.1882633120176156,,0.16866679760495354,0.11754,,0.5577382432014507,,0.33763912160072534,,Neutral,,Neutral,,0.16180034870849366,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.1546,2.0378,-8.957,-2.88081380414296,0.0016189020730378,Benign,0.2512,benign,-3.375,available,https://doi.org/10.1101/2022.10.22.513328 +R202C,NP_000537:p.Arg202Cys,"hg19,17:g.7578245G>A, hg38,17:g.7674927G>A",3.18654005481e-05,2.78352155241e-05,0.498,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127818,Conflicting classifications of pathogenicity,1,,,,,0.53035,0.08306906700134277,1.32256,1.0900457129011691,0.926455,0.8101978564505845,Neutral,Neutral,Neutral,Neutral,Neutral,0.21100447433961445,0.3156327113381417,0.11526062759355073,0.45307,-0.35124666666666665,1.1667989326283486,0.05091166666666666,0.8099344663141743,Neutral,Neutral,Neutral,Neutral,0.7603440213628448,0.1910608670825592,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.1532,2.0378,-6.9571,-2.09111881832108,0.0006767326895455,Benign,0.116,benign,-3.308,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R202D,NP_000537:p.Arg202Asp,,,,,saturation_mutlist,,,,,,,,0.38317,0.6405205190181732,,0.5025489265038662,,0.4428594632519331,,Neutral,Neutral,,Neutral,0.26581613975728907,,0.06971904821514978,0.05114,,0.49993779351885986,,0.27553889675942994,,Neutral,,Neutral,,0.3013203534032494,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.3134,2.0378,-22.2448,-3.11285594195369,0.0076304962539488,Benign,0.325,benign,-3.55,available,https://doi.org/10.1101/2022.10.22.513328 +R202E,NP_000537:p.Arg202Glu,,,,,saturation_mutlist,,,,,,,,0.42646,0.5634957826137543,,0.45642104208644124,,0.4414405210432206,,Neutral,Neutral,,Neutral,0.24733995507139894,,0.13138713285315456,-0.07578,,0.30115379212274135,,0.11268689606137067,,Neutral,,Neutral,,0.2438790361849746,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.2587,2.0378,-22.2448,-3.00713811111707,0.0018219454667677,Benign,0.2762,benign,-3.502,available,https://doi.org/10.1101/2022.10.22.513328 +R202F,NP_000537:p.Arg202Phe,,,,,saturation_mutlist,,,,,,,,-0.07283,0.24059523820877074,,0.21947934508290667,,0.07332467254145333,,Neutral,Neutral,,Neutral,0.24645131585221303,,0.18036969264892305,-0.13222,,0.09313053074961196,,-0.019544734625194023,,Neutral,,Neutral,,0.07908031209736732,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.2546,2.0378,-22.2448,-2.28820530764412,0.0314175226310784,Benign,0.3891,ambiguous,-3.568,available,https://doi.org/10.1101/2022.10.22.513328 +R202G,NP_000537:p.Arg202Gly,"hg19,17:g.7578245G>C, hg38,17:g.7674927G>C",,,0.483,"COSMIC,ClinVar,saturation_mutlist",231661,Conflicting classifications of pathogenicity,1,,,,,0.68957,0.6633267641067505,0.8121333333333333,1.1269511701832162,0.7508516666666667,0.9082605850916081,Neutral,Neutral,Neutral,Neutral,Neutral,0.3800614113057072,0.42762010752016283,0.084332483734198,0.40963,0.8834466666666666,1.349381659738726,0.6465383333333333,0.879505829869363,Neutral,Neutral,Neutral,Neutral,0.4420682850973239,0.3167411526738803,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.19,2.0378,-8.957,-1.3870717050981,0.0001162284074562,Benign,0.1515,benign,-3.34,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R202H,NP_000537:p.Arg202His,"hg19,17:g.7578244C>T, hg38,17:g.7674926C>T",,,0.528,"COSMIC,ClinVar,saturation_mutlist",135358,Conflicting classifications of pathogenicity,1,,,,,0.52049,0.16466548204421996,0.09138333333333333,0.2045221848816462,0.3059366666666667,0.3625060924408231,Neutral,Neutral,Neutral,Neutral,Neutral,0.18644868858664165,0.4975252815240202,0.10867810012702361,0.35525,0.01973,0.13554871251729658,0.18749000000000002,0.24539935625864828,Neutral,Neutral,Neutral,Neutral,0.12928663993880676,0.10561275909169515,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.0842,2.0378,-1.0929,0.19866576258103,2.2650299446572743e-09,Benign,0.0714,benign,-2.776,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R202I,NP_000537:p.Arg202Ile,,,,,saturation_mutlist,,,,,,,,0.41225,0.39307891845703125,,0.44685988552361094,,0.4295549427618055,,Neutral,Neutral,,Neutral,0.3385359141889413,,0.2770356611193301,0.58174,,0.11131057122185202,,0.34652528561092605,,Neutral,,Neutral,,0.24223214054453862,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.2518,2.0378,-22.2448,-2.91832255923989,0.1461732516526155,Benign,0.4061,ambiguous,-3.851,available,https://doi.org/10.1101/2022.10.22.513328 +R202K,NP_000537:p.Arg202Lys,,,,,saturation_mutlist,,,,,,,,-0.01889,0.17136788368225095,,0.3229808399775212,,0.1520454199887606,,Neutral,Neutral,,Neutral,0.07173689703754509,,0.11265151038573566,-0.09101,,0.32163998807702937,,0.1153149940385147,,Neutral,,Neutral,,0.16044837912183676,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.0346,2.0378,-6.9571,-1.48343747555783,2.0017178497730727e-06,Benign,0.1535,benign,-3.07,available,https://doi.org/10.1101/2022.10.22.513328 +R202L,NP_000537:p.Arg202Leu,"hg19,17:g.7578244C>A, hg38,17:g.7674926C>A",,,0.530,"COSMIC,ClinVar,saturation_mutlist",182932,Uncertain significance,2,,,,,-0.0381,0.20544229030609132,0.07573666666666666,0.006164215950515801,0.01881833333333333,-0.0159678920247421,Neutral,Neutral,Neutral,Neutral,Neutral,0.14683804683594143,0.3258078003295126,0.09299400585446177,0.04854,0.23458,-0.08334432175394833,0.14156000000000002,-0.017402160876974167,Neutral,Neutral,Neutral,Neutral,0.3555900081085894,0.16965968597523406,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.124,2.0378,-2.4814,-1.16836799688307,1.5510637556800205e-06,Benign,0.1554,benign,-3.124,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R202M,NP_000537:p.Arg202Met,,,,,saturation_mutlist,,,,,,,,-0.14225,0.23424887418746948,,0.2872260488525165,,0.07248802442625826,,Neutral,Neutral,,Neutral,0.1514346046564572,,0.12091737145275723,-0.08746,,0.26291227589880334,,0.08772613794940168,,Neutral,,Neutral,,0.12524292786625096,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.1148,2.0378,-7.3721,-1.14857701936401,1.208321248346084e-05,Benign,0.3412,ambiguous,-3.306,available,https://doi.org/10.1101/2022.10.22.513328 +R202N,NP_000537:p.Arg202Asn,,,,,saturation_mutlist,,,,,,,,0.32689,0.26905219912528994,,0.30548448967310277,,0.31618724483655136,,Neutral,Neutral,,Neutral,0.17662572297814846,,0.050427632632152844,0.23658,,0.47590674691237034,,0.3562433734561852,,Neutral,,Neutral,,0.21118934049642202,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.1614,2.0378,-7.3721,-0.797235299210452,0.0001923667934149,Benign,0.2568,benign,-3.168,available,https://doi.org/10.1101/2022.10.22.513328 +R202P,NP_000537:p.Arg202Pro,"hg19,17:g.7578244C>G, hg38,17:g.7674925_7674926delinsCG, hg38,17:g.7674926C>G",,,0.528,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",826165,Uncertain significance,1,,,,,0.92438,1.5260761308670043,2.1060133333333333,2.7934219998277663,1.5151966666666667,1.858900999913883,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.5072898554761403,0.2586069071432978,0.10188447164861832,-0.08075,1.2994333333333332,2.035202558222917,0.6093416666666666,0.9772262791114585,Neutral,Uncertain,Neutral,Neutral,3.2473272634001984,0.9849381717394037,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.3645,2.0378,-22.2448,-3.66857640737189,0.0204034678727542,Benign,0.5449,ambiguous,-3.666,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R202Q,NP_000537:p.Arg202Gln,,,,,saturation_mutlist,,,,,,,,0.22246,0.31079557418823245,,0.5287857272327129,,0.37562286361635644,,Neutral,Neutral,,Neutral,0.1772915254262648,,0.08028342063752171,-0.00925,,0.5162114127722457,,0.25348070638612286,,Neutral,,Neutral,,0.14724352960455214,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.1059,2.0378,-4.3721,-1.66575263570409,9.549324138335948e-09,Benign,0.0845,benign,-2.947,available,https://doi.org/10.1101/2022.10.22.513328 +R202S,NP_000537:p.Arg202Ser,"hg38,17:g.7674927G>T",,,0.486,"COSMIC,saturation_mutlist",,,,,,,,0.54931,0.2590255904197693,0.047393333333333336,0.5779745969468734,0.2983516666666666,0.5636422984734366,Neutral,Neutral,Neutral,Neutral,Neutral,0.19237150436433856,0.2404396086800638,0.14743674899972675,0.20758,-0.09161333333333332,0.6679741942368461,0.05798333333333333,0.43777709711842305,Neutral,Neutral,Neutral,Neutral,0.18009121657895727,0.24964102326978305,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.2229,2.0378,-22.2448,-2.81419087979135,0.000351405816512,Benign,0.28,benign,-3.262,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R202T,NP_000537:p.Arg202Thr,,,,,saturation_mutlist,,,,,,,,0.8022,0.2307031583786011,,0.536965953509847,,0.6695829767549235,,Neutral,Neutral,,Neutral,0.24051540345472516,,0.18635859741971492,0.69408,,0.5290630800500598,,0.6115715400250299,,Neutral,,Neutral,,0.22118360344364094,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.1595,2.0378,-8.957,-2.94686413850029,0.0005201075797512,Benign,0.263,benign,-3.434,available,https://doi.org/10.1101/2022.10.22.513328 +R202V,NP_000537:p.Arg202Val,,,,,saturation_mutlist,,,,,,,,0.76634,0.4413007390499115,,0.455731822408314,,0.611035911204157,,Neutral,Neutral,,Neutral,0.3415660194982825,,0.24365241308303973,0.72403,,0.26831242315718457,,0.49617121157859223,,Neutral,,Neutral,,0.21315617244675034,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.1711,2.0378,-8.957,-2.27877744646473,0.0213437490764548,Benign,0.3739,ambiguous,-3.647,available,https://doi.org/10.1101/2022.10.22.513328 +R202W,NP_000537:p.Arg202Trp,,,,,saturation_mutlist,,,,,,,,0.2417,0.2437635350227356,,-0.03159018169197927,,0.10505490915401036,,Neutral,Neutral,,Neutral,0.2512030627181701,,0.15526890675375168,0.19586,,-0.2149480115586616,,-0.009544005779330803,,Neutral,,Neutral,,0.11000792595112482,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.1723,2.0378,-8.957,-1.34112861336191,0.0049112016739677,Benign,0.1695,benign,-3.606,available,https://doi.org/10.1101/2022.10.22.513328 +R202Y,NP_000537:p.Arg202Tyr,,,,,saturation_mutlist,,,,,,,,0.07138,0.17605745077133178,,0.28680575883734677,,0.17909287941867338,,Neutral,Neutral,,Neutral,0.2577709083006878,,0.14105300060530465,-0.00986,,0.14478050279941257,,0.06746025139970628,,Neutral,,Neutral,,0.0829698632269644,63.602,10.82,91.355,6.491,,False,63.602,,neutral,neutral,neutral,,False,91.355,,neutral,neutral,neutral,uncertain,,-0.1629,2.0378,-6.3721,-0.119316417623896,0.0001134356086776,Benign,0.2333,benign,-3.407,available,https://doi.org/10.1101/2022.10.22.513328 +V203A,NP_000537:p.Val203Ala,"hg38,17:g.7674923A>G",,,0.526,"COSMIC,saturation_mutlist",,,,,,,,1.91255,1.084582221508026,2.1316333333333333,2.264697260150801,2.0220916666666664,2.0886236300754004,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.27722286591310474,0.28316074166844213,0.25418508013231716,-1.32143,1.4166666666666667,1.3209745037302472,0.04761833333333332,-0.00022774813487647094,Neutral,Neutral,Neutral,Neutral,0.5603842367717192,0.26701708160684956,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.1354,1.1312,-0.3873,0.605143927663759,3.7600521567679115e-22,Benign,0.1,benign,-2.698,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V203C,NP_000537:p.Val203Cys,,,,,saturation_mutlist,,,,,,,,1.38516,0.9408300352096558,,2.3575591385027606,,1.8713595692513803,,Uncertain,Neutral,,Neutral,0.19387218933648623,,0.21990490976228974,-0.94382,,1.533599496875321,,0.2948897484376605,,Neutral,,Neutral,,0.30559757130951143,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.1989,1.1312,-7.3721,-1.31820944315504,2.0518429432132102e-05,Benign,0.6638,pathogenic,-3.04,available,https://doi.org/10.1101/2022.10.22.513328 +V203D,NP_000537:p.Val203Asp,,,,,saturation_mutlist,,,,,,,,3.73475,2.3533942985534666,,3.2601900854552235,,3.4974700427276115,,Destabilizing,Destabilizing,,Destabilizing,0.37151795103235424,,0.42593537520858465,0.90079,,2.49624420250877,,1.6985171012543852,,Uncertain,,Neutral,,0.6364148766351121,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.4135,1.1312,-22.2448,-4.648604673011,0.0282699663548481,Benign,0.921,pathogenic,-3.617,available,https://doi.org/10.1101/2022.10.22.513328 +V203E,NP_000537:p.Val203Glu,"hg19,17:g.7578241A>T, hg38,17:g.7674923A>T",,,0.630,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",644883,Uncertain significance,1,,,,,4.0748,2.4502172374725344,6.129706666666666,3.1590482601844267,5.1022533333333335,3.6169241300922135,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.37746724863440395,0.5641199518620919,0.6688803713426552,0.14298,5.27245,2.208163569245469,2.707715,1.1755717846227345,Uncertain,Uncertain,Uncertain,Neutral,0.5092544670398091,0.5238546976729268,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,uncertain,,-0.3708,1.1312,-22.2448,-4.648604673011,0.0501222567511481,Benign,0.8955,pathogenic,-3.578,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V203F,NP_000537:p.Val203Phe,,,,,saturation_mutlist,,,,,,,,7.50536,1.5385463285446166,,2.134156115333434,,4.819758057666717,,Uncertain,Uncertain,,Destabilizing,0.2598171822082211,,0.4747481939015129,0.64341,,0.23586383999240834,,0.4396369199962042,,Neutral,,Neutral,,0.458519802057909,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.3241,1.1312,-22.2448,-5.11566355519937,0.0049972157915388,Benign,0.865,pathogenic,-3.485,available,https://doi.org/10.1101/2022.10.22.513328 +V203G,NP_000537:p.Val203Gly,,,,,saturation_mutlist,,,,,,,,3.28228,2.1524863338470457,,3.9516492454893473,,3.616964622744674,,Destabilizing,Destabilizing,,Destabilizing,0.31093564615808506,,0.2998178759636199,-1.1145,,2.965735454901957,,0.9256177274509785,,Uncertain,,Neutral,,0.22512341447198042,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.3727,1.1312,-22.2448,-4.2329573305272,0.000481486211549,Benign,0.3338,benign,-3.138,available,https://doi.org/10.1101/2022.10.22.513328 +V203H,NP_000537:p.Val203His,,,,,saturation_mutlist,,,,,,,,6.55549,2.078974862098694,,2.6045814183360094,,4.580035709168005,,Uncertain,Destabilizing,,Destabilizing,0.3118259195874339,,0.48349162086660524,1.74899,,1.0163287886801504,,1.3826593943400751,,Neutral,,Neutral,,0.05936057588904968,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.4165,1.1312,-22.2448,-5.11566355519937,0.0101663235880189,Benign,0.9702,pathogenic,-3.332,available,https://doi.org/10.1101/2022.10.22.513328 +V203I,NP_000537:p.Val203Ile,,,,,saturation_mutlist,,,,,,,,0.70426,0.6410159111022949,,0.61829976978885,,0.661279884894425,,Neutral,Neutral,,Neutral,0.2275937086559191,,0.31428433257748933,0.51536,,0.230643181869051,,0.3730015909345255,,Neutral,,Neutral,,0.41773230265014444,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.1147,1.1312,-8.957,-2.94329085917356,3.6445472307610144e-05,Benign,0.228,benign,-3.202,available,https://doi.org/10.1101/2022.10.22.513328 +V203K,NP_000537:p.Val203Lys,,,,,saturation_mutlist,,,,,,,,3.42267,2.3104563474655153,,3.550564104805955,,3.486617052402978,,Destabilizing,Destabilizing,,Destabilizing,0.3457006115126494,,0.9312090292281047,0.27579,,2.3669796138933434,,1.3213848069466718,,Uncertain,,Neutral,,0.2662327859770666,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.4098,1.1312,-22.2448,-5.11566355519937,0.0476967810697828,Benign,0.9634,pathogenic,-3.612,available,https://doi.org/10.1101/2022.10.22.513328 +V203L,NP_000537:p.Val203Leu,"hg19,17:g.7578242C>A, hg19,17:g.7578242C>G, hg19,17:g.7674924C>A, hg19,17:g.7674924C>G, hg38,17:g.7674924C>A, hg38,17:g.7674924C>G",,,0.506,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","482235, 482218","Uncertain significance, Uncertain significance","2, 2",,,,,1.56113,1.341581208705902,4.2015899999999995,1.1113345828180334,2.88136,1.3362322914090168,Uncertain,Neutral,Uncertain,Uncertain,Neutral,0.28304436274703154,1.1324830781075717,0.29958996846249264,0.27782,3.6444466666666666,0.36317794753913096,1.9611333333333334,0.3204989737695655,Uncertain,Neutral,Neutral,Neutral,2.309824912633471,0.23900055505490372,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.1746,1.1312,-7.957,-1.57779146542502,0.0017716703619329,Benign,0.7401,pathogenic,-3.241,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V203M,NP_000537:p.Val203Met,"hg19,17:g.7578242C>T, hg38,17:g.7674924C>T",,,0.519,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182933,Uncertain significance,3,,,,,1.96498,1.5849158620834352,4.190593333333333,1.7687344813501358,3.0777866666666664,1.8668572406750679,Uncertain,Neutral,Uncertain,Destabilizing,Neutral,0.28171102615195476,0.6590920583820002,0.3300460338218208,-0.78083,2.0337866666666664,0.6689778486054311,0.6264783333333332,-0.05592607569728447,Uncertain,Neutral,Neutral,Neutral,1.5743365409452816,0.0912936696851053,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.2566,1.1312,-22.2448,-3.60071629476165,0.0116913567518064,Benign,0.5787,pathogenic,-3.49,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V203N,NP_000537:p.Val203Asn,,,,,saturation_mutlist,,,,,,,,3.05657,2.3683101415634153,,2.4428162266284676,,2.7496931133142337,,Uncertain,Destabilizing,,Uncertain,0.3512314766146272,,0.3871309838243535,0.15068,,1.5959528133074716,,0.8733164066537358,,Neutral,,Neutral,,0.3375126420976598,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.4014,1.1312,-22.2448,-3.26511550718159,0.0186188879414486,Benign,0.8106,pathogenic,-3.471,available,https://doi.org/10.1101/2022.10.22.513328 +V203P,NP_000537:p.Val203Pro,,,,,saturation_mutlist,,,,,,,,3.44713,1.7303577804565429,,3.877128995772987,,3.6621294978864936,,Destabilizing,Uncertain,,Destabilizing,0.25361286977576325,,0.4707375707461337,-1.16735,,3.8940941913278464,,1.363372095663923,,Uncertain,,Neutral,,1.457323610907353,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.3703,1.1312,-6.3721,-1.36074022148326,8.173724054183048e-07,Benign,0.7184,pathogenic,-3.02,available,https://doi.org/10.1101/2022.10.22.513328 +V203Q,NP_000537:p.Val203Gln,,,,,saturation_mutlist,,,,,,,,3.69454,2.2248784351348876,,2.5830224215081325,,3.1387812107540665,,Uncertain,Destabilizing,,Destabilizing,0.33728156620633887,,0.4297065681855114,0.01388,,1.6396255795967865,,0.8267527897983932,,Neutral,,Neutral,,0.17542594010632742,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,uncertain,,-0.3814,1.1312,-22.2448,-4.648604673011,0.0008900520319589,Benign,0.8935,pathogenic,-3.327,available,https://doi.org/10.1101/2022.10.22.513328 +V203R,NP_000537:p.Val203Arg,,,,,saturation_mutlist,,,,,,,,5.75295,2.252414274215698,,2.73403589336082,,4.24349294668041,,Uncertain,Destabilizing,,Destabilizing,0.3280922860527409,,0.7845946104573178,0.6384,,1.5147155547083395,,1.0765577773541697,,Neutral,,Neutral,,0.34329709734045816,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.4308,1.1312,-22.2448,-5.11566355519937,0.0288267796521733,Benign,0.9252,pathogenic,-3.586,available,https://doi.org/10.1101/2022.10.22.513328 +V203S,NP_000537:p.Val203Ser,,,,,saturation_mutlist,,,,,,,,2.56894,1.8109220170974731,,2.9540333227994275,,2.7614866613997138,,Uncertain,Uncertain,,Uncertain,0.28713665563700547,,0.41575041976449706,-0.55101,,1.9085148103624736,,0.6787524051812368,,Neutral,,Neutral,,0.3593262382750121,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.2513,1.1312,-2.7872,-0.756068950576836,5.749610172039073e-08,Benign,0.234,benign,-2.779,available,https://doi.org/10.1101/2022.10.22.513328 +V203T,NP_000537:p.Val203Thr,,,,,saturation_mutlist,,,,,,,,1.76013,1.273409631252289,,1.956310734246067,,1.8582203671230335,,Neutral,Uncertain,,Neutral,0.21595018179699157,,0.31232809630228625,-0.47687,,1.2849860572258274,,0.4040580286129137,,Neutral,,Neutral,,0.35055249314876274,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.2659,1.1312,-22.2448,-1.12174146154177,1.3743102891514895e-09,Benign,0.2401,benign,-2.855,available,https://doi.org/10.1101/2022.10.22.513328 +V203W,NP_000537:p.Val203Trp,,,,,saturation_mutlist,,,,,,,,13.37273,1.720462670326233,,2.5801399063518993,,7.97643495317595,,Uncertain,Uncertain,,Destabilizing,0.28726176683444843,,0.7890697300842521,3.12065,,0.4034785964786251,,1.7620642982393124,,Uncertain,,Neutral,,0.5895562010962352,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.3646,1.1312,-22.2448,-5.11566355519937,0.0159672758446756,Benign,0.9909,pathogenic,-3.673,available,https://doi.org/10.1101/2022.10.22.513328 +V203Y,NP_000537:p.Val203Tyr,,,,,saturation_mutlist,,,,,,,,9.27291,1.7036595821380616,,2.619910478026813,,5.946410239013407,,Uncertain,Uncertain,,Destabilizing,0.28600213038771827,,0.5848717441971897,1.12163,,0.4961076228857191,,0.8088688114428595,,Neutral,,Neutral,,0.49055983589382274,18.112,9.596,14.8,8.787,,False,18.112,,neutral,neutral,neutral,,False,14.8,,neutral,neutral,neutral,damaging,,-0.3675,1.1312,-22.2448,-5.11566355519937,0.0096803345253476,Benign,0.9737,pathogenic,-3.527,available,https://doi.org/10.1101/2022.10.22.513328 +E204A,NP_000537:p.Glu204Ala,"hg19,17:g.7578238T>G, hg38,17:g.7674920T>G",,,0.600,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.49052,0.4848363673686981,0.59637,0.17011283946871547,0.543445,0.33031641973435777,Neutral,Neutral,Neutral,Neutral,Neutral,0.11739336727258752,0.2930604696417902,0.156595831263115,0.16367,0.17857333333333336,0.5068462324532016,0.17112166666666667,0.3352581162266008,Neutral,Neutral,Neutral,Neutral,0.2820566132691962,0.01076318122733422,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1018,1.6413,-8.9541,-4.38455113914571,0.0001680683421586,Benign,0.2159,benign,-3.495,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E204C,NP_000537:p.Glu204Cys,,,,,saturation_mutlist,,,,,,,,0.29144,-0.07200457096099852,,0.7018958568537145,,0.49666792842685725,,Neutral,Neutral,,Neutral,0.11824846210785715,,0.11786965879521163,0.00116,,1.0695495254283527,,0.5353547627141764,,Neutral,,Neutral,,0.15798808817269117,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1712,1.6413,-8.9541,-3.42761125374806,0.001161367945352,Benign,0.8336,pathogenic,-3.682,available,https://doi.org/10.1101/2022.10.22.513328 +E204D,NP_000537:p.Glu204Asp,"hg19,17:g.7578237C>A, hg19,17:g.7578237C>G, hg19,17:g.7674919C>G, hg38,17:g.7674919C>G",,,0.494,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3460304,Likely benign,1,,,,,0.37811,0.5939075827598572,0.8299333333333333,0.3467013128277279,0.6040216666666667,0.36240565641386396,Neutral,Neutral,Neutral,Neutral,Neutral,0.30730968777544637,0.2150665568815591,0.1275503710312806,0.39486,0.21689666666666665,0.6186415225840579,0.3058783333333333,0.506750761292029,Neutral,Neutral,Neutral,Neutral,0.4204108625565657,0.04834445144531849,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.0544,1.6413,-6.3692,-1.70479957730539,4.0150175792827125e-06,Benign,0.1919,benign,-3.002,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E204F,NP_000537:p.Glu204Phe,,,,,saturation_mutlist,,,,,,,,-0.35622,0.08498583555221557,,-0.3083025446788695,,-0.3322612723394347,,Neutral,Neutral,,Neutral,0.20846537976429255,,0.06269729450309021,-0.72118,,-0.13738956998602078,,-0.4292847849930104,,Neutral,,Neutral,,0.13851678547573593,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.2166,1.6413,-22.2419,-4.31069640536162,3.215117439658388e-05,Benign,0.8283,pathogenic,-3.883,available,https://doi.org/10.1101/2022.10.22.513328 +E204G,NP_000537:p.Glu204Gly,"hg19,17:g.7578238T>C, hg38,17:g.7674920T>C",3.18796225453e-05,,0.604,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",949463,Uncertain significance,1,,,,,1.21938,1.2748055171966552,1.7572566666666667,0.9793333696034647,1.4883183333333334,1.0993566848017324,Neutral,Neutral,Uncertain,Neutral,Neutral,0.1497721472884736,0.21288213207208234,0.1921508556810884,0.53062,1.0060066666666667,1.3841081577435084,0.7683133333333334,0.9573640788717541,Neutral,Neutral,Neutral,Neutral,0.2897001450158806,0.06956234759205684,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1954,1.6413,-22.2419,-5.25170119144998,0.051540374832763,Benign,0.394,ambiguous,-3.716,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E204H,NP_000537:p.Glu204His,,,,,saturation_mutlist,,,,,,,,0.49413,0.4514694476127625,,-0.18347990824914703,,0.1553250458754265,,Neutral,Neutral,,Neutral,0.1415487822939208,,0.1136644196025531,0.24663,,0.1427126387600763,,0.19467131938003815,,Neutral,,Neutral,,0.06460879881145565,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1283,1.6413,-6.6322,-2.91505188433534,1.0857033450435562e-05,Benign,0.4794,ambiguous,-3.456,available,https://doi.org/10.1101/2022.10.22.513328 +E204I,NP_000537:p.Glu204Ile,,,,,saturation_mutlist,,,,,,,,-0.92102,-0.11853219509124756,,-0.5068325050997503,,-0.7139262525498751,,Neutral,Neutral,,Neutral,0.1763260644589004,,0.16068305406131972,-0.53863,,-0.27693587761365357,,-0.4077829388068268,,Neutral,,Neutral,,0.13719206497622283,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1461,1.6413,-7.3692,-2.70082644780406,9.70835372266311e-05,Benign,0.4776,ambiguous,-3.624,available,https://doi.org/10.1101/2022.10.22.513328 +E204K,NP_000537:p.Glu204Lys,"hg38,17:g.7674921C>T",,,0.624,"COSMIC,saturation_mutlist",,,,,,,,-0.3433,0.5645369482040405,0.5551,0.013192668818107175,0.10590000000000002,-0.16505366559094642,Neutral,Neutral,Neutral,Neutral,Neutral,0.16563597343135275,0.3776617683412853,0.17551016423881696,-0.34542,0.02199666666666668,0.37581050332137284,-0.16171166666666667,0.015195251660686415,Neutral,Neutral,Neutral,Neutral,0.44430316424211475,0.02934792025531411,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1062,1.6413,-5.4948,-1.35436664368131,2.2253332968248668e-05,Benign,0.2764,benign,-3.493,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E204L,NP_000537:p.Glu204Leu,,,,,saturation_mutlist,,,,,,,,-0.73586,0.1433437156677246,,-0.5454119154791983,,-0.6406359577395991,,Neutral,Neutral,,Neutral,0.14464858608133505,,0.09879500541968181,-0.61448,,-0.34611432590415675,,-0.48029716295207836,,Neutral,,Neutral,,0.03725758359890012,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.142,1.6413,-6.1468,-2.6742616447969,1.933611226199361e-05,Benign,0.5007,ambiguous,-3.471,available,https://doi.org/10.1101/2022.10.22.513328 +E204M,NP_000537:p.Glu204Met,,,,,saturation_mutlist,,,,,,,,-0.94524,0.1488220524787903,,-0.1792277131937523,,-0.5622338565968761,,Neutral,Neutral,,Neutral,0.10953131002542424,,0.08379088798329191,-0.91609,,0.024251815264659766,,-0.4459190923676701,,Neutral,,Neutral,,0.0726090548283285,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1051,1.6413,-8.9541,-1.65168695611997,0.00091566086447,Benign,0.512,ambiguous,-3.623,available,https://doi.org/10.1101/2022.10.22.513328 +E204N,NP_000537:p.Glu204Asn,,,,,saturation_mutlist,,,,,,,,0.36705,0.7445040607452392,,0.22917058495055576,,0.29811029247527787,,Neutral,Neutral,,Neutral,0.21594687198765372,,0.15920032414093457,0.38456,,0.5730982667028394,,0.4788291333514197,,Neutral,,Neutral,,0.13298056757068957,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1162,1.6413,-6.6322,-1.7299470999347,0.0001696355237895,Benign,0.3671,ambiguous,-3.438,available,https://doi.org/10.1101/2022.10.22.513328 +E204P,NP_000537:p.Glu204Pro,,,,,saturation_mutlist,,,,,,,,2.70879,2.1761923027038574,,4.434032607471081,,3.57141130373554,,Uncertain,Destabilizing,,Destabilizing,0.25986330903921523,,0.9071633913703301,3.67391,,4.915092770165294,,4.294501385082647,,Destabilizing,,Destabilizing,,1.852587745123156,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.3266,1.6413,-22.2419,-6.32700542377472,0.1376994998130876,Benign,0.9601,pathogenic,-3.936,available,https://doi.org/10.1101/2022.10.22.513328 +E204Q,NP_000537:p.Glu204Gln,"hg19,17:g.7578239C>G, hg19,17:g.7674921C>G, hg38,17:g.7674921C>G",,,0.458,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.09106,0.23193468332290648,-0.06859333333333333,0.10872076116409683,-0.07982666666666666,0.008830380582048415,Neutral,Neutral,Neutral,Neutral,Neutral,0.11137231668384226,0.02573628610002271,0.09030580617724566,-0.15512,0.02052333333333335,0.4457334889894675,-0.06729833333333334,0.14530674449473374,Neutral,Neutral,Neutral,Neutral,0.4968432365333042,0.07260567094853543,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.0314,1.6413,-0.5363,-0.625135789158261,4.5104494186125317e-10,Benign,0.1258,benign,-3.088,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E204R,NP_000537:p.Glu204Arg,,,,,saturation_mutlist,,,,,,,,-0.14223,0.5705360889434814,,-0.26260482287215015,,-0.20241741143607506,,Neutral,Neutral,,Neutral,0.1540349831864076,,0.1612953189317871,-0.19768,,0.06651052165491995,,-0.06558473917254001,,Neutral,,Neutral,,0.04554802531687923,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1674,1.6413,-5.6323,-2.63740080551945,1.3039883511171566e-07,Benign,0.3603,ambiguous,-3.418,available,https://doi.org/10.1101/2022.10.22.513328 +E204S,NP_000537:p.Glu204Ser,,,,,saturation_mutlist,,,,,,,,0.72651,0.4369830226898193,,0.40888560789306894,,0.5676978039465345,,Neutral,Neutral,,Neutral,0.13988012927450033,,0.16558404199850404,0.21714,,0.8054024756624013,,0.5112712378312007,,Neutral,,Neutral,,0.05891721394812532,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1102,1.6413,-7.9541,-2.8566033594517,3.05848938498136e-06,Benign,0.2584,benign,-3.378,available,https://doi.org/10.1101/2022.10.22.513328 +E204T,NP_000537:p.Glu204Thr,,,,,saturation_mutlist,,,,,,,,0.09041,0.15850879192352296,,0.12366344925248092,,0.10703672462624046,,Neutral,Neutral,,Neutral,0.13973780269296812,,0.1394866174806124,0.09551,,0.4760614510002381,,0.28578572550011905,,Neutral,,Neutral,,0.12283902952230467,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1312,1.6413,-8.9541,-2.57267836171135,0.0001090884621613,Benign,0.2644,benign,-3.426,available,https://doi.org/10.1101/2022.10.22.513328 +E204V,NP_000537:p.Glu204Val,"hg19,17:g.7578238T>A, hg38,17:g.7674920T>A",,,0.588,"COSMIC,ClinVar,saturation_mutlist",1751713,Uncertain significance,1,,,,,-0.17844,-0.10608346939086914,-0.17573666666666665,-0.35417703026744646,-0.17708833333333332,-0.2663085151337232,Neutral,Neutral,Neutral,Neutral,Neutral,0.18056889338012308,0.22672942351818587,0.13751345699545958,-0.02319,-0.31870666666666664,-0.0942916378334459,-0.1709483333333333,-0.05874081891672295,Neutral,Neutral,Neutral,Neutral,0.6561526906817413,0.1540893549342004,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1007,1.6413,-6.1468,-2.67756988432955,6.02845067582403e-06,Benign,0.3037,benign,-3.386,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E204W,NP_000537:p.Glu204Trp,,,,,saturation_mutlist,,,,,,,,-0.3537,0.08616386651992798,,-0.6822819100284883,,-0.5179909550142441,,Neutral,Neutral,,Neutral,0.22326707839470478,,0.012998591331898141,-0.28741,,-0.5205647988450913,,-0.4039873994225457,,Neutral,,Neutral,,0.07919918476060843,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.2267,1.6413,-22.2419,-2.99371569302676,0.004567682384385,Benign,0.9271,pathogenic,-4.038,available,https://doi.org/10.1101/2022.10.22.513328 +E204Y,NP_000537:p.Glu204Tyr,,,,,saturation_mutlist,,,,,,,,-0.19026,0.15476616621017455,,-0.22663453627908037,,-0.20844726813954018,,Neutral,Neutral,,Neutral,0.21007517299954281,,0.0206847137793824,-0.58568,,-0.0446069587544321,,-0.31514347937721604,,Neutral,,Neutral,,0.15678429798367846,53.3,7.785,60.365,12.395,,False,53.3,,neutral,neutral,neutral,,False,60.365,,neutral,neutral,neutral,uncertain,,-0.1395,1.6413,-6.9542,-2.90435543695547,1.993132469555638e-06,Benign,0.753,pathogenic,-3.61,available,https://doi.org/10.1101/2022.10.22.513328 +Y205A,NP_000537:p.Tyr205Ala,,,,,saturation_mutlist,,,,,,,,4.03839,2.712639992237091,,4.257413262661156,,4.147901631330578,,Destabilizing,Destabilizing,,Destabilizing,0.528782213417437,,0.19979998961946083,-2.53922,,2.762916386630162,,0.111848193315081,,Uncertain,,Neutral,,0.4237958008566345,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.4452,0.0744,-22.239,-7.97634045107894,0.8484287975992963,Pathogenic,0.9987,pathogenic,-4.334,available,https://doi.org/10.1101/2022.10.22.513328 +Y205C,NP_000537:p.Tyr205Cys,"hg19,17:g.7578235T>C, hg19,17:g.7674917T>C, hg38,17:g.7674917T>C",,,0.873,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376681,Pathogenic,2,,,,,3.52137,1.969931674003601,4.987753333333333,4.451186328308976,4.254561666666667,3.986278164154488,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.5074328066319393,0.18606206246542845,0.21408674187968774,-2.4977,1.0596366666666668,2.8925260935561563,-0.7190316666666666,0.19741304677807814,Uncertain,Uncertain,Neutral,Neutral,0.7798361602427925,0.34555906704423306,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.4159,0.0744,-22.239,-7.97634045107894,0.4868874191242851,Uncertain,0.9974,pathogenic,-3.948,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y205D,NP_000537:p.Tyr205Asp,"hg19,17:g.7578236A>C, hg19,17:g.7674918A>C, hg38,17:g.7674918A>C",,,0.925,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376686,Pathogenic/Likely pathogenic,2,,,,,4.86149,2.894671235084534,5.65238,5.194505296872884,5.256935,5.0279976484364415,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.36379386121709983,0.18353611978754134,0.29843755794574317,0.01462,2.5936533333333336,3.7465765455572915,1.3041366666666667,1.8805982727786457,Uncertain,Uncertain,Neutral,Neutral,0.6702583765152725,0.6755329474777727,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.4594,0.0744,-22.239,-7.97634045107894,0.826422286181473,Pathogenic,0.9971,pathogenic,-4.351,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y205E,NP_000537:p.Tyr205Glu,,,,,saturation_mutlist,,,,,,,,4.63543,2.896094551086426,,4.744577186008341,,4.690003593004171,,Destabilizing,Destabilizing,,Destabilizing,0.36614949555958803,,0.2070631855635916,0.32272,,3.614639656567434,,1.968679828283717,,Uncertain,,Neutral,,0.5974673896450743,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.4881,0.0744,-22.239,-7.97634045107894,0.8579196539345881,Pathogenic,0.9995,pathogenic,-4.427,available,https://doi.org/10.1101/2022.10.22.513328 +Y205F,NP_000537:p.Tyr205Phe,"hg19,17:g.7578235T>A, hg19,17:g.7674917T>A, hg38,17:g.7674917T>A",,,0.823,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.06297,0.7252660179138184,0.7918366666666667,0.07553107930468923,0.42740333333333336,0.06925053965234462,Neutral,Neutral,Neutral,Neutral,Neutral,0.21358889418511184,0.039636296777350706,0.2839021511075381,-0.42058,-0.06677666666666666,0.6997356160410005,-0.24367833333333333,0.13957780802050027,Neutral,Neutral,Neutral,Neutral,0.1819255262157812,0.3054157971055063,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,uncertain,,-0.2827,0.0744,-22.239,-3.70658794075006,0.4994217292377448,Uncertain,0.787,pathogenic,-3.521,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y205G,NP_000537:p.Tyr205Gly,,,,,saturation_mutlist,,,,,,,,5.1633,2.937607879638672,,6.0027436948530655,,5.583021847426533,,Destabilizing,Destabilizing,,Destabilizing,0.3879987584440222,,0.3758444250802334,-2.16144,,4.243794834210766,,1.041177417105383,,Uncertain,,Neutral,,0.6684763818890188,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.5158,0.0744,-22.239,-7.97634045107894,0.8528058277747647,Pathogenic,0.9901,pathogenic,-4.416,available,https://doi.org/10.1101/2022.10.22.513328 +Y205H,NP_000537:p.Tyr205His,"hg19,17:g.7578236A>G, hg19,17:g.7674918A>G, hg38,17:g.7674918A>G",,0.0,0.900,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376685,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,2.96545,1.6463940048217773,3.3385466666666663,2.5526860449374005,3.1519983333333332,2.7590680224687003,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.2759742969150192,0.18445860571472997,0.205257146873377,0.37987,2.03186,1.9988266882601626,1.205865,1.1893483441300814,Uncertain,Neutral,Neutral,Neutral,0.46503763030533346,0.2761735579278516,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.2851,0.0744,-8.9511,-2.98739685309101,0.4831833645818426,Uncertain,0.9986,pathogenic,-3.708,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y205I,NP_000537:p.Tyr205Ile,,,,,saturation_mutlist,,,,,,,,3.3846,2.2422776508331297,,3.16215698935603,,3.273378494678015,,Destabilizing,Destabilizing,,Destabilizing,0.45232550646619885,,0.13160175063979365,-2.23248,,1.7207934781533798,,-0.25584326092331,,Uncertain,,Neutral,,0.45115459228508853,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.3814,0.0744,-7.3663,-4.48512104279824,0.0781555506380318,Benign,0.9917,pathogenic,-3.728,available,https://doi.org/10.1101/2022.10.22.513328 +Y205K,NP_000537:p.Tyr205Lys,,,,,saturation_mutlist,,,,,,,,3.64436,2.8392451190948487,,5.203351025737,,4.423855512868499,,Destabilizing,Destabilizing,,Destabilizing,0.27948181563672825,,0.2155851311983396,-0.54703,,3.981235604712999,,1.7171028023564996,,Uncertain,,Neutral,,1.0407012362332926,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.5134,0.0744,-22.239,-7.97634045107894,0.8626125582076489,Pathogenic,0.9996,pathogenic,-4.506,available,https://doi.org/10.1101/2022.10.22.513328 +Y205L,NP_000537:p.Tyr205Leu,,,,,saturation_mutlist,,,,,,,,1.48923,2.3764354038238524,,2.4083704721870416,,1.9488002360935208,,Uncertain,Destabilizing,,Neutral,0.48783996587210027,,0.22081415230351853,-1.56703,,1.4978924006122167,,-0.034568799693891594,,Neutral,,Neutral,,0.4978823172799728,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.4343,0.0744,-22.239,-7.17417508196052,0.8630548277704961,Pathogenic,0.9799,pathogenic,-4.175,available,https://doi.org/10.1101/2022.10.22.513328 +Y205M,NP_000537:p.Tyr205Met,,,,,saturation_mutlist,,,,,,,,0.77486,2.4853734970092773,,2.5876096767147225,,1.6812348383573612,,Uncertain,Destabilizing,,Neutral,0.45903249389156653,,0.20383813937469603,-2.31423,,1.8985815995323894,,-0.2078242002338052,,Uncertain,,Neutral,,0.4613202815523915,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.3865,0.0744,-22.239,-7.17417508196052,0.8346588921503038,Pathogenic,0.9963,pathogenic,-4.366,available,https://doi.org/10.1101/2022.10.22.513328 +Y205N,NP_000537:p.Tyr205Asn,"hg19,17:g.7578236A>T, hg19,17:g.7674918A>T, hg38,17:g.7674918A>T",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376684,Conflicting classifications of pathogenicity,1,,,,,3.94258,2.5686546087265016,4.473696666666666,4.089893328785359,4.208138333333333,4.01623666439268,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.3641903555912578,0.20180811452686664,0.1909648988158151,-1.49027,1.7360533333333332,2.8285107516062715,0.12289166666666662,0.6691203758031358,Neutral,Uncertain,Neutral,Neutral,0.7410613610371427,0.5248298329423214,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.4384,0.0744,-22.239,-7.97634045107894,0.8576871658455092,Pathogenic,0.9856,pathogenic,-4.265,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y205P,NP_000537:p.Tyr205Pro,,,,,saturation_mutlist,,,,,,,,3.41727,2.519543662071228,,7.562214216857119,,5.489742108428559,,Destabilizing,Destabilizing,,Destabilizing,0.3579842968317949,,0.5523208260235596,-2.10808,,4.828741623010475,,1.3603308115052375,,Uncertain,,Neutral,,1.6373322361823353,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.5694,0.0744,-22.239,-7.97634045107894,0.8489966387617147,Pathogenic,0.997,pathogenic,-4.426,available,https://doi.org/10.1101/2022.10.22.513328 +Y205Q,NP_000537:p.Tyr205Gln,,,,,saturation_mutlist,,,,,,,,3.82683,2.8699574279785156,,4.040524183395706,,3.933677091697853,,Destabilizing,Destabilizing,,Destabilizing,0.33640832881367644,,0.1802437436249558,-0.33419,,2.968069965569523,,1.3169399827847614,,Uncertain,,Neutral,,0.5350912107470616,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.4629,0.0744,-22.239,-7.97634045107894,0.8706937730778788,Pathogenic,0.9998,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328 +Y205R,NP_000537:p.Tyr205Arg,,,,,saturation_mutlist,,,,,,,,5.0322,2.606660556793213,,4.25112200724919,,4.641661003624595,,Destabilizing,Destabilizing,,Destabilizing,0.2386425794282534,,0.21932444738284584,0.59808,,3.0943094538394593,,1.8461947269197296,,Uncertain,,Neutral,,0.9888824798011264,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.5087,0.0744,-22.239,-7.97634045107894,0.8444362660685936,Pathogenic,0.9992,pathogenic,-4.343,available,https://doi.org/10.1101/2022.10.22.513328 +Y205S,NP_000537:p.Tyr205Ser,"hg19,17:g.7578235T>G, hg19,17:g.7674917T>G, hg38,17:g.7674917T>G",,,0.852,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3634430,Uncertain significance,1,Likely oncogenic,1,,,4.91887,2.7260725259780885,5.839569999999999,5.094093998942797,5.37922,5.006481999471399,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.4076629912290756,0.24333638664751042,0.2781070949026583,-2.03817,1.3586166666666666,3.32189060065109,-0.3397766666666667,0.641860300325545,Uncertain,Uncertain,Neutral,Neutral,0.5064435846392195,0.629359286976117,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.4499,0.0744,-22.239,-7.97634045107894,0.8466488385054057,Pathogenic,0.9955,pathogenic,-4.212,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y205T,NP_000537:p.Tyr205Thr,,,,,saturation_mutlist,,,,,,,,4.05193,2.4696291875839234,,4.285358869336964,,4.168644434668481,,Destabilizing,Destabilizing,,Destabilizing,0.46928704503875845,,0.19729320597568312,-1.94929,,2.666510951129281,,0.35861047556464043,,Uncertain,,Neutral,,0.4054842864368169,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.4686,0.0744,-22.239,-7.97634045107894,0.8669915166990285,Pathogenic,0.9982,pathogenic,-4.26,available,https://doi.org/10.1101/2022.10.22.513328 +Y205V,NP_000537:p.Tyr205Val,,,,,saturation_mutlist,,,,,,,,3.05564,2.2356645107269286,,3.371227956148866,,3.213433978074433,,Destabilizing,Destabilizing,,Destabilizing,0.5421319748433726,,0.14841087661377617,-2.71012,,1.656069598075768,,-0.5270252009621159,,Uncertain,,Neutral,,0.5159176465084694,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.4468,0.0744,-22.239,-7.17417508196052,0.8244621688231445,Pathogenic,0.9875,pathogenic,-4.217,available,https://doi.org/10.1101/2022.10.22.513328 +Y205W,NP_000537:p.Tyr205Trp,,,,,saturation_mutlist,,,,,,,,2.3818,0.6657507133483886,,0.7143745008772598,,1.54808725043863,,Uncertain,Neutral,,Neutral,0.23206999336038212,,0.23554484269709583,3.12872,,1.1303499073200287,,2.1295349536600146,,Uncertain,,Uncertain,,0.43656818939090225,15.299,3.254,26.74,21.152,,True,15.299,,uncertain,,,,True,26.74,,uncertain,,,damaging,,-0.3628,0.0744,-22.239,-4.78639668458736,0.8631746615947256,Pathogenic,0.9814,pathogenic,-4.253,available,https://doi.org/10.1101/2022.10.22.513328 +L206A,NP_000537:p.Leu206Ala,,,,,saturation_mutlist,,,,,,,,1.02903,0.72193772315979,,1.9293434548326678,,1.4791867274163337,,Neutral,Neutral,,Neutral,0.30999257150132353,,0.33991791082042866,0.14012,,1.2803497754360864,,0.7102348877180432,,Neutral,,Neutral,,0.20587375951784675,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.1418,2.226,-7.9541,-2.63845354004875,0.0003864027986074,Benign,0.1294,benign,-3.34,available,https://doi.org/10.1101/2022.10.22.513328 +L206C,NP_000537:p.Leu206Cys,,,,,saturation_mutlist,,,,,,,,0.8198,0.06932276725769043,,2.169724644082817,,1.4947623220414084,,Uncertain,Neutral,,Neutral,0.176769420081479,,0.26219080786374804,0.04579,,1.646070215632524,,0.845930107816262,,Neutral,,Neutral,,0.11823542106257709,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.131,2.226,-7.9541,-2.12599269961508,3.654437724408375e-06,Benign,0.2169,benign,-3.264,available,https://doi.org/10.1101/2022.10.22.513328 +L206D,NP_000537:p.Leu206Asp,,,,,saturation_mutlist,,,,,,,,1.34793,0.8109093117713928,,2.111342629252426,,1.7296363146262133,,Uncertain,Neutral,,Neutral,0.2959596587703325,,0.5677915364293857,0.68935,,1.5113242164916352,,1.1003371082458175,,Neutral,,Neutral,,0.1729239747754278,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.3362,2.226,-22.2419,-3.46851593909712,0.0268072779233461,Benign,0.6253,pathogenic,-3.632,available,https://doi.org/10.1101/2022.10.22.513328 +L206E,NP_000537:p.Leu206Glu,,,,,saturation_mutlist,,,,,,,,1.0378,0.7096221375465394,,1.8163148443461958,,1.4270574221730978,,Neutral,Neutral,,Neutral,0.3277383972579787,,0.425213340375614,0.33448,,1.1879674730648473,,0.7612237365324237,,Neutral,,Neutral,,0.17462707095742086,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.2365,2.226,-8.9541,-2.91921010170217,0.0010161061500154,Benign,0.2341,benign,-3.448,available,https://doi.org/10.1101/2022.10.22.513328 +L206F,NP_000537:p.Leu206Phe,"hg19,17:g.7578231C>G, hg38,17:g.7674913C>G",,,0.421,"COSMIC,ClinVar,saturation_mutlist",3972452,Uncertain significance,1,,,,,0.73737,0.12447386026382447,0.38560333333333335,0.7999716729001006,0.5614866666666667,0.7686708364500503,Neutral,Neutral,Neutral,Neutral,Neutral,0.22658769593755043,0.28103581317847887,0.016008527738295055,0.50376,-0.29512333333333335,0.3349689383759378,0.10431833333333332,0.4193644691879689,Neutral,Neutral,Neutral,Neutral,0.4271850835670907,0.10533751199948214,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.0544,2.226,-3.8667,-0.991137868643407,2.180275711527735e-05,Benign,0.1276,benign,-3.264,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L206G,NP_000537:p.Leu206Gly,,,,,saturation_mutlist,,,,,,,,1.40475,1.270784046649933,,2.9787289090961724,,2.1917394545480864,,Uncertain,Uncertain,,Uncertain,0.3750358447435562,,0.3786362335499095,0.26737,,2.1186532898956094,,1.1930116449478048,,Uncertain,,Neutral,,0.21090632499626238,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.2895,2.226,-22.2419,-4.04638785210432,0.0191232011836353,Benign,0.4231,ambiguous,-3.534,available,https://doi.org/10.1101/2022.10.22.513328 +L206H,NP_000537:p.Leu206His,,,,,saturation_mutlist,,,,,,,,1.34877,0.503816704750061,,1.3530342850976111,,1.3509021425488057,,Neutral,Neutral,,Neutral,0.24704005291596365,,0.25780032601637537,1.16337,,0.6552701272078564,,0.9093200636039283,,Neutral,,Neutral,,0.02267670898192644,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.1704,2.226,-5.2538,-1.9130043991147,4.716631673265454e-06,Benign,0.1235,benign,-3.216,available,https://doi.org/10.1101/2022.10.22.513328 +L206I,NP_000537:p.Leu206Ile,,,,,saturation_mutlist,,,,,,,,0.20476,-0.43362189054489136,,0.5767643052589877,,0.3907621526294939,,Neutral,Neutral,,Neutral,0.22676028430971498,,0.1497235327284784,-0.06998,,0.44932722496453614,,0.18967361248226808,,Neutral,,Neutral,,0.11838977102040343,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.0057,2.226,-5.9542,-1.33128833739288,3.2085905307627056e-05,Benign,0.0898,benign,-3.146,available,https://doi.org/10.1101/2022.10.22.513328 +L206K,NP_000537:p.Leu206Lys,,,,,saturation_mutlist,,,,,,,,0.44413,0.5428811812400818,,1.7326985805254669,,1.0884142902627334,,Neutral,Neutral,,Neutral,0.2737147113226783,,0.2852684572859041,0.00127,,1.0417923294149396,,0.5215311647074699,,Neutral,,Neutral,,0.14631855533905935,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.2236,2.226,-6.6322,-2.1961200838818,0.000208876334999,Benign,0.2252,benign,-3.438,available,https://doi.org/10.1101/2022.10.22.513328 +L206M,NP_000537:p.Leu206Met,,,,,saturation_mutlist,,,,,,,,0.03168,0.2695267701148987,,0.8511354395273091,,0.44140771976365456,,Neutral,Neutral,,Neutral,0.14788239128829522,,0.20170734935171708,-0.39969,,0.6121672207219444,,0.10623861036097221,,Neutral,,Neutral,,0.036401819244545386,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.0274,2.226,-5.6323,-1.3227862130961,4.299926353001501e-07,Benign,0.0836,benign,-3.132,available,https://doi.org/10.1101/2022.10.22.513328 +L206N,NP_000537:p.Leu206Asn,,,,,saturation_mutlist,,,,,,,,1.08859,0.6609857416152954,,1.789728747463094,,1.4391593737315471,,Neutral,Neutral,,Neutral,0.23583551776855766,,0.42488970080130267,0.5974,,1.0564459994575766,,0.8269229997287884,,Neutral,,Neutral,,0.1525287275846544,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.2825,2.226,-22.2419,-3.10546378898311,0.0197923431339189,Benign,0.3178,benign,-3.554,available,https://doi.org/10.1101/2022.10.22.513328 +L206P,NP_000537:p.Leu206Pro,,,,,saturation_mutlist,,,,,,,,3.85838,1.7075087809562683,,5.265361442109511,,4.561870721054755,,Destabilizing,Uncertain,,Destabilizing,0.3507549326752288,,1.3987543374395754,3.51922,,6.098764848678152,,4.808992424339076,,Destabilizing,,Destabilizing,,0.21028178408095727,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.2303,2.226,-8.9541,-4.94905577644568,0.039911724190222,Benign,0.9462,pathogenic,-3.704,available,https://doi.org/10.1101/2022.10.22.513328 +L206Q,NP_000537:p.Leu206Gln,,,,,saturation_mutlist,,,,,,,,0.8735,0.5761860179901123,,1.6073646775544714,,1.2404323387772358,,Neutral,Neutral,,Neutral,0.2804008049849819,,0.31176556325832183,0.14923,,1.050904054146108,,0.600067027073054,,Neutral,,Neutral,,0.06821690372923223,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.15,2.226,-5.4948,-2.1184728057432,8.566072079068902e-05,Benign,0.088,benign,-3.176,available,https://doi.org/10.1101/2022.10.22.513328 +L206R,NP_000537:p.Leu206Arg,,,,,saturation_mutlist,,,,,,,,0.70724,0.5450065243244171,,1.370151189349796,,1.038695594674898,,Neutral,Neutral,,Neutral,0.2913181090728491,,0.15476792184144575,0.16137,,0.5778405775583869,,0.36960528877919346,,Neutral,,Neutral,,0.08561143979107809,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.2109,2.226,-5.7843,-2.22695946322539,0.0002699928533423,Benign,0.1358,benign,-3.367,available,https://doi.org/10.1101/2022.10.22.513328 +L206S,NP_000537:p.Leu206Ser,"hg19,17:g.7578232A>G, hg38,17:g.7674914A>G",,,0.605,"ClinVar,saturation_mutlist",439319,Conflicting classifications of pathogenicity,1,,,,,1.3602,0.7033538484573364,1.756916666666667,2.341945825838384,1.5585583333333335,1.851072912919192,Neutral,Uncertain,Neutral,Neutral,Neutral,0.3462423974559009,0.383795326733172,0.37294302174743704,-0.00521,0.8585033333333333,1.5468533212568358,0.4266466666666666,0.770821660628418,Neutral,Neutral,Neutral,Neutral,0.09112649864641766,0.17832428396110533,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.162,2.226,-5.9542,-0.883449963984159,6.964653094575099e-05,Benign,0.1231,benign,-3.284,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L206T,NP_000537:p.Leu206Thr,,,,,saturation_mutlist,,,,,,,,1.22018,0.35832321166992187,,1.8570183979702932,,1.5385991989851466,,Neutral,Neutral,,Neutral,0.3469133752179316,,0.2869620149411266,0.23301,,1.2221979142088752,,0.7276039571044376,,Neutral,,Neutral,,0.1274157619018531,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.15,2.226,-8.9541,-2.18011020573432,0.000157397146934,Benign,0.1118,benign,-3.267,available,https://doi.org/10.1101/2022.10.22.513328 +L206V,NP_000537:p.Leu206Val,,,,,saturation_mutlist,,,,,,,,0.76038,-0.2653083324432373,,0.8382323741485594,,0.7993061870742797,,Neutral,Neutral,,Neutral,0.22267237202058757,,0.1426726265589228,0.10937,,0.6616096448162883,,0.3854898224081441,,Neutral,,Neutral,,0.15324377363598005,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.0163,2.226,-0.9263,-0.433154516033745,1.3973935317773002e-05,Benign,0.0691,benign,-3.021,available,https://doi.org/10.1101/2022.10.22.513328 +L206W,NP_000537:p.Leu206Trp,"hg19,17:g.7578232A>C, hg38,17:g.7674914A>C",,,0.526,"ClinVar,saturation_mutlist",2679229,Uncertain significance,1,,,,,1.08736,0.3264255928993225,,0.6646639787380971,,0.8760119893690486,,Neutral,Neutral,,Neutral,0.2690539510335943,,0.18133126873056574,1.0741,,0.0690738321815433,,0.5715869160907717,,Neutral,,Neutral,,0.019679076171781443,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.1714,2.226,-7.3692,-1.8942896075093,0.0003461990523398,Benign,0.1824,benign,-3.546,available,https://doi.org/10.1101/2022.10.22.513328 +L206Y,NP_000537:p.Leu206Tyr,,,,,saturation_mutlist,,,,,,,,0.67622,0.23157294511795043,,1.057486123605888,,0.866853061802944,,Neutral,Neutral,,Neutral,0.27857392624345123,,0.13227252761195654,0.62312,,0.3990018669081543,,0.5110609334540772,,Neutral,,Neutral,,0.05297772954860542,38.165,7.993,46.07,14.755,,True,38.165,,neutral,neutral,neutral,,True,46.07,,neutral,neutral,neutral,uncertain,,-0.1592,2.226,-6.3692,-1.88544557925491,0.0001144127208066,Benign,0.2663,benign,-3.464,available,https://doi.org/10.1101/2022.10.22.513328 +D207A,NP_000537:p.Asp207Ala,"hg38,17:g.7674911T>G",,,0.518,"COSMIC,saturation_mutlist",,,,,,,,0.2925,0.43756518363952634,0.3324233333333333,0.7901806832060659,0.31246166666666664,0.5413403416030329,Neutral,Neutral,Neutral,Neutral,Neutral,0.674094103907619,0.36086063841260874,0.3996212762459055,-0.06239,0.8803866666666665,1.6097873312727327,0.40899833333333324,0.7736986656363664,Neutral,Neutral,Neutral,Neutral,0.48267346038036474,0.2280647289555563,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.159,1.3244,-8.9541,-4.79992424352891,0.0292428135374466,Benign,0.4022,ambiguous,-3.539,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D207C,NP_000537:p.Asp207Cys,,,,,saturation_mutlist,,,,,,,,0.25062,-0.004780573844909668,,1.4013047459773544,,0.8259623729886773,,Neutral,Neutral,,Neutral,0.6809845728162105,,0.3311801950937237,-0.50184,,1.8326840998714207,,0.6654220499357104,,Neutral,,Neutral,,0.26382800532536765,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.2005,1.3244,-8.9541,-4.77078726216089,0.0022373521891778,Benign,0.8244,pathogenic,-3.788,available,https://doi.org/10.1101/2022.10.22.513328 +D207E,NP_000537:p.Asp207Glu,"hg19,17:g.7578228A>C, hg38,17:g.7674910A>C, hg38,17:g.7674910A>T",,,"0.435, 0.436","COSMIC,ClinVar,saturation_mutlist",3809687,Likely benign,1,,,,,0.11447,0.1431659495830536,-0.08854999999999998,0.44159977229430386,0.012960000000000013,0.27803488614715194,Neutral,Neutral,Neutral,Neutral,Neutral,0.6826271694150221,0.5863119857209128,0.4316705446647786,-0.30017,-0.7879833333333334,1.5215029574443877,-0.5440766666666667,0.6106664787221938,Neutral,Neutral,Neutral,Neutral,0.5898787660942618,0.22738987461016716,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.0618,1.3244,-0.7015,-0.414044459748668,1.039597481433019e-08,Benign,0.2799,benign,-2.846,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D207F,NP_000537:p.Asp207Phe,,,,,saturation_mutlist,,,,,,,,0.03159,0.0832775330543518,,0.15235821623923262,,0.09197410811961632,,Neutral,Neutral,,Neutral,0.8275725885806008,,0.5242859479341939,0.26534,,0.40164900984095997,,0.33349450492048,,Neutral,,Neutral,,0.5998998845511491,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.327,1.3244,-22.2419,-5.10400276278224,0.0398889079999335,Benign,0.8629,pathogenic,-3.836,available,https://doi.org/10.1101/2022.10.22.513328 +D207G,NP_000537:p.Asp207Gly,"hg19,17:g.7578229T>C, hg38,17:g.7674911T>C",,,0.616,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3972466,Uncertain significance,1,,,,,0.6188,0.8270390943437814,1.0362799999999999,1.3068090040607467,0.8275399999999999,0.9628045020303734,Neutral,Neutral,Neutral,Neutral,Neutral,0.6212875728684546,0.054927152362621794,0.3140884426544041,0.81478,2.8387766666666665,2.9484759945110355,1.8267783333333332,1.8816279972555177,Uncertain,Uncertain,Neutral,Neutral,0.7951755934103835,0.18311746112608712,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.238,1.3244,-22.2419,-4.83904568381669,0.0334052144353968,Benign,0.5033,ambiguous,-3.412,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D207H,NP_000537:p.Asp207His,"hg19,17:g.7578230C>G, hg38,17:g.7674912C>G",,,0.538,"cBioPortal,ClinVar,saturation_mutlist",919639,Uncertain significance,1,,,,,0.62101,0.3154488909244537,0.5092966666666667,0.2511127438287268,0.5651533333333334,0.43606137191436334,Neutral,Neutral,Neutral,Neutral,Neutral,0.6624884518988832,0.9480690439461088,0.3517666962546125,0.88502,0.03140666666666666,0.9525502954510903,0.45821333333333336,0.9187851477255451,Neutral,Neutral,Neutral,Neutral,0.6804885447154044,0.25279514945861165,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.1684,1.3244,-8.9541,-3.10747195468716,0.0157807360005776,Benign,0.6425,pathogenic,-3.529,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D207I,NP_000537:p.Asp207Ile,,,,,saturation_mutlist,,,,,,,,-0.05116,0.10831661462783813,,0.43308956296120155,,0.19096478148060078,,Neutral,Neutral,,Neutral,0.8813498193526228,,0.4786183976008695,-1.14693,,0.15879932792227047,,-0.49406533603886477,,Neutral,,Neutral,,0.14042915368179087,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.2514,1.3244,-8.9541,-4.33749158016168,0.0101649704416947,Benign,0.7299,pathogenic,-3.698,available,https://doi.org/10.1101/2022.10.22.513328 +D207K,NP_000537:p.Asp207Lys,,,,,saturation_mutlist,,,,,,,,-0.14738,0.6648191732168197,,0.729205912715733,,0.2909129563578665,,Neutral,Neutral,,Neutral,0.9312964423359825,,0.4298103534018644,-0.31878,,1.9583701911086955,,0.8197950955543477,,Neutral,,Neutral,,0.08439710990832873,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.2976,1.3244,-22.2419,-4.971732951177,0.0064225936997019,Benign,0.8223,pathogenic,-3.639,available,https://doi.org/10.1101/2022.10.22.513328 +D207L,NP_000537:p.Asp207Leu,,,,,saturation_mutlist,,,,,,,,-0.5159,0.3487466037273407,,-0.07608599522387367,,-0.29599299761193687,,Neutral,Neutral,,Neutral,0.7422472141811253,,0.5299021794061591,-1.39839,,0.09477826054807514,,-0.6518058697259624,,Neutral,,Neutral,,0.10418763206416225,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.3129,1.3244,-22.2419,-4.19389362327633,0.0101975091220079,Benign,0.7412,pathogenic,-3.677,available,https://doi.org/10.1101/2022.10.22.513328 +D207M,NP_000537:p.Asp207Met,,,,,saturation_mutlist,,,,,,,,-0.56306,0.3440377736091614,,0.39501400375829293,,-0.08402299812085354,,Neutral,Neutral,,Neutral,0.8176456779285253,,0.43084628250731466,-1.3335,,0.6097041838690038,,-0.36189790806549804,,Neutral,,Neutral,,0.139500190504254,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.1736,1.3244,-6.9542,-2.75020105792436,0.0002134724885294,Benign,0.849,pathogenic,-3.518,available,https://doi.org/10.1101/2022.10.22.513328 +D207N,NP_000537:p.Asp207Asn,"hg19,17:g.7578230C>T, hg38,17:g.7674912C>T",,,0.406,"cBioPortal,ClinVar,saturation_mutlist",2969522,Conflicting classifications of pathogenicity,1,,,,,0.39381,0.41183505557477473,0.07947999999999998,0.513961597963318,0.236645,0.453885798981659,Neutral,Neutral,Neutral,Neutral,Neutral,0.3493130107738973,0.4238712745633985,0.15167334683897352,-0.02042,0.38956999999999997,1.4024864742870287,0.184575,0.6910332371435143,Neutral,Neutral,Neutral,Neutral,0.2708763062112791,0.26251055906880955,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.1206,1.3244,-7.9541,-0.904858873091193,3.834097103144792e-05,Benign,0.267,benign,-3.22,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D207P,NP_000537:p.Asp207Pro,,,,,saturation_mutlist,,,,,,,,0.2243,0.6873077145218849,,1.5531847378358374,,0.8887423689179187,,Neutral,Neutral,,Neutral,0.5420885183291543,,0.6403653593020483,0.32622,,3.001362723758,,1.6637913618790001,,Uncertain,,Neutral,,0.08119185843361439,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.3638,1.3244,-22.2419,-6.07082004462946,0.2655726614104212,Benign,0.9147,pathogenic,-3.805,available,https://doi.org/10.1101/2022.10.22.513328 +D207Q,NP_000537:p.Asp207Gln,,,,,saturation_mutlist,,,,,,,,0.16851,0.3688884401321411,,0.7051371376557621,,0.4368235688278811,,Neutral,Neutral,,Neutral,0.8304996877187601,,0.3347044264242732,-0.17838,,1.389935158687801,,0.6057775793439005,,Neutral,,Neutral,,0.252868715340512,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.1809,1.3244,-7.9541,-1.89273746913801,5.514817960445841e-05,Benign,0.637,pathogenic,-3.31,available,https://doi.org/10.1101/2022.10.22.513328 +D207R,NP_000537:p.Asp207Arg,,,,,saturation_mutlist,,,,,,,,0.03248,0.6420142585039139,,0.4888060227341853,,0.2606430113670926,,Neutral,Neutral,,Neutral,0.9079820219568804,,0.45527647061575977,-0.00146,,1.3917002356782096,,0.6951201178391048,,Neutral,,Neutral,,0.08344824651672694,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.2608,1.3244,-8.9541,-3.22175504917137,0.0002605374830291,Benign,0.8124,pathogenic,-3.652,available,https://doi.org/10.1101/2022.10.22.513328 +D207S,NP_000537:p.Asp207Ser,,,,,saturation_mutlist,,,,,,,,0.5013,0.17350918114185332,,0.7588582023350234,,0.6300791011675118,,Neutral,Neutral,,Neutral,0.5985207277262454,,0.3214576942824082,0.19401,,2.0366353451747443,,1.1153226725873722,,Uncertain,,Neutral,,0.17287479287650542,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.1523,1.3244,-6.3692,-2.13296355094089,2.7689885639221726e-06,Benign,0.2727,benign,-3.146,available,https://doi.org/10.1101/2022.10.22.513328 +D207T,NP_000537:p.Asp207Thr,,,,,saturation_mutlist,,,,,,,,0.46836,0.2645722734928131,,0.6851886342458888,,0.5767743171229445,,Neutral,Neutral,,Neutral,0.8383591151940188,,0.36642665536911945,-0.23611,,1.2939013728481894,,0.5288956864240947,,Neutral,,Neutral,,0.19712032739935612,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.1874,1.3244,-7.3692,-3.17235150117949,0.0002913022891228,Benign,0.4691,ambiguous,-3.268,available,https://doi.org/10.1101/2022.10.22.513328 +D207V,NP_000537:p.Asp207Val,,,,,saturation_mutlist,,,,,,,,0.33752,0.12860592007637023,,0.610793915047627,,0.4741569575238135,,Neutral,Neutral,,Neutral,0.8924275109152991,,0.40368689172264083,-0.86057,,0.3411494869532781,,-0.2597102565233609,,Neutral,,Neutral,,0.18958900067949672,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.201,1.3244,-7.9541,-3.57855740441127,0.0071365951346793,Benign,0.5058,ambiguous,-3.468,available,https://doi.org/10.1101/2022.10.22.513328 +D207W,NP_000537:p.Asp207Trp,,,,,saturation_mutlist,,,,,,,,0.1642,-0.06578422069549561,,-0.10136502949756605,,0.03141748525121698,,Neutral,Neutral,,Neutral,0.72270216597151,,0.49393734170811293,0.87752,,0.2703160828610454,,0.5739180414305227,,Neutral,,Neutral,,0.6578292932208581,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.3074,1.3244,-22.2419,-5.1609407880589,0.3508762168245638,Uncertain,0.9553,pathogenic,-4.189,available,https://doi.org/10.1101/2022.10.22.513328 +D207Y,NP_000537:p.Asp207Tyr,"hg19,17:g.7674912C>A, hg38,17:g.7674912C>A",,,0.606,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.18976,0.10069575786590576,0.0803866666666666,0.2643094298619431,0.13507333333333332,0.22703471493097155,Neutral,Neutral,Neutral,Neutral,Neutral,0.8469157503215164,0.9829029917997447,0.47506661667185557,0.46431,-0.4565766666666667,0.706510912168287,0.003866666666666657,0.5854104560841435,Neutral,Neutral,Neutral,Neutral,0.3388635733677427,0.6244686145465432,51.844,12.718,30.5,18.244,,True,51.844,,neutral,neutral,neutral,,True,30.5,,neutral,neutral,neutral,uncertain,,-0.2718,1.3244,-22.2419,-4.88084400394254,0.1053364684538075,Benign,0.5888,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208A,NP_000537:p.Asp208Ala,"hg19,17:g.7578226T>G, hg38,17:g.7674908T>G",,,0.931,"COSMIC,ClinVar,saturation_mutlist",2759300,Uncertain significance,1,,,,,1.91822,1.592033131122589,,0.9123509294649425,,1.4152854647324713,,Neutral,Uncertain,,Neutral,0.369054614348773,,0.013040406043675037,0.92162,,1.1956560818474686,,1.0586380409237344,,Neutral,,Neutral,,0.10195377068079371,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.3303,0.2005,-22.2419,-5.75119319772927,0.2852018153011107,Benign,0.9084,pathogenic,-3.775,available,https://doi.org/10.1101/2022.10.22.513328 +D208C,NP_000537:p.Asp208Cys,,,,,saturation_mutlist,,,,,,,,1.9969,0.9001204085350036,,1.3596850882600944,,1.6782925441300471,,Neutral,Neutral,,Neutral,0.30733046913128736,,0.13213483411709917,1.05819,,1.542315860176627,,1.3002529300883134,,Neutral,,Neutral,,0.04172569040121677,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.3717,0.2005,-22.2419,-5.15731424630418,0.0890686896346477,Benign,0.8798,pathogenic,-3.811,available,https://doi.org/10.1101/2022.10.22.513328 +D208E,NP_000537:p.Asp208Glu,"hg19,17:g.7578225G>C, hg19,17:g.7578225G>T, hg38,17:g.7674907G>C, hg38,17:g.7674907G>T",,,0.767,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3972451,Uncertain significance,1,,,,,1.24412,1.3710789632797242,3.0537433333333333,0.941656775340534,2.1489316666666665,1.0928883876702669,Uncertain,Neutral,Uncertain,Uncertain,Neutral,0.3338743724724728,0.4300247155946065,0.11505308476697033,0.29692,2.2501166666666665,0.8777292213929115,1.2735183333333333,0.5873246106964558,Uncertain,Neutral,Neutral,Neutral,0.41342982478556406,0.1609348135414102,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.2752,0.2005,-22.2419,-3.87557754153043,0.0417699064669473,Benign,0.9192,pathogenic,-3.51,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208F,NP_000537:p.Asp208Phe,,,,,saturation_mutlist,,,,,,,,2.20541,1.3835579824447632,,0.7405612273298202,,1.4729856136649102,,Uncertain,Uncertain,,Neutral,0.3632503069062022,,0.2530445417170685,0.79068,,0.44360436652555246,,0.6171421832627763,,Neutral,,Neutral,,0.0966344962767381,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.4304,0.2005,-22.2419,-7.0826306968347,0.793894066260276,Pathogenic,0.9936,pathogenic,-4.326,available,https://doi.org/10.1101/2022.10.22.513328 +D208G,NP_000537:p.Asp208Gly,"hg19,17:g.7578226T>C, hg19,17:g.7674908T>C, hg38,17:g.7674908T>C",,,0.944,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",584922,Uncertain significance,2,,,,,2.40448,1.9138494729995728,5.272336666666667,1.6623611997478411,3.8384083333333336,2.0334205998739208,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.3895216701613837,0.45690819751406886,0.17998194324192382,1.13392,4.2199566666666675,2.0252199216552462,2.6769383333333336,1.579569960827623,Uncertain,Uncertain,Uncertain,Neutral,0.29697543358930456,0.3033341255856473,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.2736,0.2005,-8.9541,-6.23147236261918,0.1292548314789588,Benign,0.9278,pathogenic,-3.544,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208H,NP_000537:p.Asp208His,"hg19,17:g.7578227C>G, hg38,17:g.7674909C>G",,,0.930,"COSMIC,ClinVar,saturation_mutlist",826261,Uncertain significance,2,,,,,2.75095,1.2078823971748351,3.10272,0.502241484697981,2.926835,1.6265957423489905,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.41250596050896715,1.7010788332898237,0.14184924875262064,1.46111,2.4967133333333336,0.3914176274596513,1.9789116666666668,0.9262638137298256,Uncertain,Neutral,Neutral,Neutral,0.29268456403135146,0.0795838702381721,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.2667,0.2005,-7.9541,-5.09335841444029,0.0276594069680791,Benign,0.9284,pathogenic,-3.554,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208I,NP_000537:p.Asp208Ile,"hg38,17:g.7674908_7674909delinsAT",,,,"COSMIC,saturation_mutlist",,,,,,,,3.29104,1.5206135177612305,2.88265,0.8715305032873095,3.0868450000000003,2.0812852516436546,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.3592835709680216,0.8806196455148312,0.06909334397728568,0.8419,1.9051,0.8593012747618284,1.3735,0.8506006373809142,Neutral,Neutral,Neutral,Neutral,0.40395594916607763,0.09402215008695755,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.4226,0.2005,-22.2419,-7.03768940174965,0.7281322364209232,Pathogenic,0.9852,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208K,NP_000537:p.Asp208Lys,,,,,saturation_mutlist,,,,,,,,2.45392,1.970526475906372,,1.1002122908969343,,1.777066145448467,,Uncertain,Uncertain,,Neutral,0.3548285947083052,,0.1610278849379008,1.13721,,1.2675308740075029,,1.2023704370037516,,Neutral,,Neutral,,0.2069144128091914,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.401,0.2005,-22.2419,-6.7330108051808,0.4219543998764645,Uncertain,0.9897,pathogenic,-3.943,available,https://doi.org/10.1101/2022.10.22.513328 +D208L,NP_000537:p.Asp208Leu,,,,,saturation_mutlist,,,,,,,,1.85811,1.5818974494934082,,0.39428475477312563,,1.1261973773865628,,Neutral,Uncertain,,Neutral,0.3232915287633245,,0.13337024232101446,0.51793,,0.2933417661108167,,0.4056358830554083,,Neutral,,Neutral,,0.1375383906005811,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.4163,0.2005,-22.2419,-7.03768940174965,0.5929163018041799,Uncertain,0.9822,pathogenic,-4.055,available,https://doi.org/10.1101/2022.10.22.513328 +D208M,NP_000537:p.Asp208Met,,,,,saturation_mutlist,,,,,,,,1.65667,1.6476894283294679,,0.7059739389639264,,1.1813219694819632,,Neutral,Uncertain,,Neutral,0.334893700383446,,0.14151688706168872,0.34374,,0.6110813757619162,,0.4774106878809581,,Neutral,,Neutral,,0.19930472999063048,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.355,0.2005,-22.2419,-7.03768940174965,0.6727155892824782,Uncertain,0.9938,pathogenic,-4.174,available,https://doi.org/10.1101/2022.10.22.513328 +D208N,NP_000537:p.Asp208Asn,"hg19,17:g.7578227C>T, hg19,17:g.7674909C>T, hg38,17:g.7674909C>T",,,0.760,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1752332,Likely benign,1,,,,,1.82646,0.7299998450279236,1.9861666666666669,0.2763344520147974,1.9063133333333333,1.0513972260073987,Neutral,Neutral,Neutral,Neutral,Neutral,0.24760712230447887,0.26471041086859853,0.17666756422120872,1.01081,1.4824233333333332,0.3279504851858798,1.2466166666666667,0.6693802425929399,Neutral,Neutral,Neutral,Neutral,0.24981386568581193,0.08025170004829534,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.2189,0.2005,-6.9542,-2.30040921412221,1.853547860211612e-05,Benign,0.5927,pathogenic,-3.313,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208P,NP_000537:p.Asp208Pro,,,,,saturation_mutlist,,,,,,,,5.5477,2.0767929124832154,,5.368190060709257,,5.457945030354629,,Destabilizing,Destabilizing,,Destabilizing,0.49141852930406776,,0.5100245925244115,1.58063,,6.089786597875826,,3.8352082989379133,,Uncertain,,Destabilizing,,0.3413461766951249,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.4672,0.2005,-22.2419,-7.87606241147806,0.7448049927605078,Pathogenic,0.9908,pathogenic,-3.944,available,https://doi.org/10.1101/2022.10.22.513328 +D208Q,NP_000537:p.Asp208Gln,,,,,saturation_mutlist,,,,,,,,2.2864,1.6039277195930481,,1.0093226595636335,,1.6478613297818168,,Uncertain,Uncertain,,Neutral,0.37845716611053176,,0.11406729448649779,1.04693,,0.9837076600637014,,1.0153188300318505,,Neutral,,Neutral,,0.12198387650130162,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.3572,0.2005,-22.2419,-4.52954470710509,0.3541481243655876,Uncertain,0.9775,pathogenic,-3.988,available,https://doi.org/10.1101/2022.10.22.513328 +D208R,NP_000537:p.Asp208Arg,,,,,saturation_mutlist,,,,,,,,2.72457,1.9005204343795776,,0.8272290387021505,,1.7758995193510752,,Uncertain,Uncertain,,Neutral,0.3384405161142469,,0.19526177844286047,1.50863,,0.9527668866062919,,1.230698443303146,,Neutral,,Neutral,,0.1696737697653063,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.432,0.2005,-22.2419,-6.5325523348345,0.3246561183944878,Uncertain,0.9835,pathogenic,-3.881,available,https://doi.org/10.1101/2022.10.22.513328 +D208S,NP_000537:p.Asp208Ser,,,,,saturation_mutlist,,,,,,,,2.16516,1.066315965652466,,1.0765316565482685,,1.6208458282741343,,Uncertain,Uncertain,,Neutral,0.2683643931178045,,0.040192448597853515,1.12796,,1.203810643796847,,1.1658853218984235,,Neutral,,Neutral,,0.08277450751230475,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.2689,0.2005,-8.9541,-5.86478755963323,0.0056821531298285,Benign,0.755,pathogenic,-3.546,available,https://doi.org/10.1101/2022.10.22.513328 +D208T,NP_000537:p.Asp208Thr,,,,,saturation_mutlist,,,,,,,,2.95909,1.546940474510193,,1.1163426111300767,,2.0377163055650387,,Uncertain,Uncertain,,Uncertain,0.32974602218272925,,0.01998171491180895,1.29034,,1.1843717304726498,,1.2373558652363248,,Neutral,,Neutral,,0.08757278922066489,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.2908,0.2005,-7.3692,-3.47471301712091,0.0056765997197539,Benign,0.9442,pathogenic,-3.498,available,https://doi.org/10.1101/2022.10.22.513328 +D208V,NP_000537:p.Asp208Val,"hg19,17:g.7578226T>A, hg19,17:g.7674908T>A, hg38,17:g.7674908T>A",,,0.950,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1036023,Conflicting classifications of pathogenicity,1,,,,,2.91715,1.5647562074661254,2.51009,0.7825354814123112,2.7136199999999997,1.8498427407061555,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.4133502762173817,0.584668016798137,0.12101623441074168,1.09136,2.020976666666667,0.8639179691275171,1.5561683333333334,0.9776389845637585,Uncertain,Neutral,Neutral,Neutral,0.22104111734144746,0.04450465919445824,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.3773,0.2005,-22.2419,-6.045583408159,0.7264256741791977,Pathogenic,0.9529,pathogenic,-4.068,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208W,NP_000537:p.Asp208Trp,,,,,saturation_mutlist,,,,,,,,3.2745,1.317080202102661,,0.417879149401569,,1.8461895747007846,,Uncertain,Uncertain,,Neutral,0.4127536156067799,,0.2815554146469769,1.58416,,0.2627426588231747,,0.9234513294115874,,Neutral,,Neutral,,0.14018118650061975,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.4108,0.2005,-22.2419,-7.0826306968347,0.7834313570062118,Pathogenic,0.998,pathogenic,-4.453,available,https://doi.org/10.1101/2022.10.22.513328 +D208Y,NP_000537:p.Asp208Tyr,"hg19,17:g.7578227C>A, hg38,17:g.7674909C>A",,,0.943,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1350980,Conflicting classifications of pathogenicity,1,,,,,2.29282,1.4918568634986877,4.259863333333333,0.8461616225632594,3.2763416666666663,1.5694908112816297,Uncertain,Uncertain,Uncertain,Destabilizing,Neutral,0.48336214488948903,1.2723972858698218,0.25950051360834964,1.0176,1.6475066666666667,0.5798242331285729,1.3325533333333333,0.7987121165642865,Neutral,Neutral,Neutral,Neutral,0.4671043482516037,0.07130390857952652,25.741,10.988,46.535,14.247,,True,25.741,,neutral,neutral,neutral,,True,46.535,,neutral,neutral,neutral,uncertain,,-0.3752,0.2005,-22.2419,-7.0826306968347,0.7347456192823629,Pathogenic,0.948,pathogenic,-4.178,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R209A,NP_000537:p.Arg209Ala,,,,,saturation_mutlist,,,,,,,,0.50227,0.031763367652893046,,0.6119623993369739,,0.557116199668487,,Neutral,Neutral,,Neutral,0.12114044128556643,,0.406291459520473,0.24535,,0.44590935359382744,,0.3456296767969137,,Neutral,,Neutral,,0.1559034415394354,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.0842,2.6472,-6.1468,-0.475070592540745,1.0567254641788617e-10,Benign,0.1483,benign,-2.885,available,https://doi.org/10.1101/2022.10.22.513328 +R209C,NP_000537:p.Arg209Cys,,,,,saturation_mutlist,,,,,,,,0.55022,-0.16661023378372192,,1.0443437481319007,,0.7972818740659504,,Neutral,Neutral,,Neutral,0.09107390003600602,,0.222271862869394,0.53277,,1.1098827292745843,,0.8213263646372921,,Neutral,,Neutral,,0.177929438522831,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.1023,2.6472,-7.9541,-1.21074608663182,1.3730434435277309e-05,Benign,0.1559,benign,-3.136,available,https://doi.org/10.1101/2022.10.22.513328 +R209D,NP_000537:p.Arg209Asp,,,,,saturation_mutlist,,,,,,,,0.51558,0.16867672204971312,,0.562256373815179,,0.5389181869075895,,Neutral,Neutral,,Neutral,0.14729773425303452,,0.4610894786963926,0.40013,,0.3368414324699689,,0.36848571623498444,,Neutral,,Neutral,,0.38064580296520156,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.1707,2.6472,-5.2538,-1.21820925377946,3.5919638424953456e-08,Benign,0.3081,benign,-3.054,available,https://doi.org/10.1101/2022.10.22.513328 +R209E,NP_000537:p.Arg209Glu,,,,,saturation_mutlist,,,,,,,,0.64728,0.11353614807128906,,0.6578701682098004,,0.6525750841049002,,Neutral,Neutral,,Neutral,0.137677449654991,,0.39690960677485976,0.22952,,0.16532708406609678,,0.1974235420330484,,Neutral,,Neutral,,0.3197688601126835,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.1135,2.6472,-4.7843,-0.462460081260259,1.894627386620856e-13,Benign,0.1404,benign,-2.95,available,https://doi.org/10.1101/2022.10.22.513328 +R209F,NP_000537:p.Arg209Phe,,,,,saturation_mutlist,,,,,,,,0.27314,0.08009485602378844,,0.264733440455571,,0.2689367202277855,,Neutral,Neutral,,Neutral,0.15305231333960106,,0.10200662179564728,0.05504,,0.11196961199734079,,0.0835048059986704,,Neutral,,Neutral,,0.07051011198641073,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.1307,2.6472,-8.9541,-2.64961744699681,0.000503303118731,Benign,0.3972,ambiguous,-3.282,available,https://doi.org/10.1101/2022.10.22.513328 +R209G,NP_000537:p.Arg209Gly,"hg19,17:g.7578224T>C, hg38,17:g.7674906T>C",,,0.635,"COSMIC,ClinVar,saturation_mutlist",627819,Conflicting classifications of pathogenicity,1,,,,,0.42445,0.21572783946990967,0.4955766666666667,1.0128089370064617,0.4600133333333334,0.7186294685032308,Neutral,Neutral,Neutral,Neutral,Neutral,0.10242998377399412,0.15508645338075863,0.4452569209469282,0.35023,0.9721066666666666,1.0458691323017137,0.6611683333333332,0.6980495661508569,Neutral,Neutral,Neutral,Neutral,0.5516168949753282,0.3758216775811947,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.1169,2.6472,-5.6323,-1.39133951331861,1.0547779696158344e-08,Benign,0.1043,benign,-2.951,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R209H,NP_000537:p.Arg209His,,,,,saturation_mutlist,,,,,,,,0.41509,-0.05583714485168457,,0.2267969823154007,,0.3209434911577004,,Neutral,Neutral,,Neutral,0.12145156679569304,,0.19797182542042666,0.53449,,0.052048439105155525,,0.2932692195525778,,Neutral,,Neutral,,0.1487590920796689,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.0683,2.6472,-8.9541,-2.03245846017917,1.0898994699904045e-05,Benign,0.1087,benign,-3.032,available,https://doi.org/10.1101/2022.10.22.513328 +R209I,NP_000537:p.Arg209Ile,"hg19,17:g.7578223C>A, hg19,17:g.7674905C>A, hg38,17:g.7674905C>A",,,0.532,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.63764,0.041396892070770235,-0.24093,0.3257045783079678,0.198355,0.48167228915398386,Neutral,Neutral,Neutral,Neutral,Neutral,0.0787338790276886,0.1356669932838001,0.24857885406229743,0.37002,0.6147366666666666,0.0951410505567246,0.4923783333333333,0.23258052527836232,Neutral,Neutral,Neutral,Neutral,0.48152086464543664,0.0968884347137409,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.1198,2.6472,-7.3692,-0.664010578646347,1.2550150352454437e-07,Benign,0.1491,benign,-3.079,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R209K,NP_000537:p.Arg209Lys,"hg19,17:g.7578223C>T, hg19,17:g.7674905C>T, hg38,17:g.7674905C>T",,,0.453,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",962629,Conflicting classifications of pathogenicity,1,,,,,0.2069,-0.04950160503387448,-0.16281333333333334,0.4920040797676142,0.02204333333333333,0.3494520398838071,Neutral,Neutral,Neutral,Neutral,Neutral,0.0441746080020482,0.22544409422786446,0.2751558825678352,-0.02641,-0.25986666666666663,0.21605356343928564,-0.1431383333333333,0.09482178171964283,Neutral,Neutral,Neutral,Neutral,0.2929129802897479,0.17483729667154987,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,0.034,2.6472,-4.4948,-0.10428217322617,4.1594327209504056e-10,Benign,0.0655,benign,-2.795,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R209L,NP_000537:p.Arg209Leu,,,,,saturation_mutlist,,,,,,,,0.37716,0.04829739332199095,,-0.19438619054772419,,0.0913869047261379,,Neutral,Neutral,,Neutral,0.08733674066237013,,0.19249433518273346,0.12848,,-0.11118820186573614,,0.008645899067131937,,Neutral,,Neutral,,0.009494052501206125,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.0833,2.6472,-5.4948,-0.965442351395789,1.6286105068538043e-08,Benign,0.1549,benign,-3.004,available,https://doi.org/10.1101/2022.10.22.513328 +R209M,NP_000537:p.Arg209Met,,,,,saturation_mutlist,,,,,,,,0.34167,0.13877487182617185,,0.1703616902160173,,0.2560158451080086,,Neutral,Neutral,,Neutral,0.07583998276483453,,0.13232625792554284,0.08263,,0.23860956145170364,,0.1606197807258518,,Neutral,,Neutral,,0.0621450256188036,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.0668,2.6472,-8.9541,-0.752997651173962,5.533786452087644e-05,Benign,0.1626,benign,-3.141,available,https://doi.org/10.1101/2022.10.22.513328 +R209N,NP_000537:p.Arg209Asn,,,,,saturation_mutlist,,,,,,,,0.30882,0.022024154663085927,,0.24017617774054903,,0.2744980888702745,,Neutral,Neutral,,Neutral,0.08715710965421351,,0.23605224607707506,0.40318,,0.39082707155729796,,0.397003535778649,,Neutral,,Neutral,,0.2067403251947489,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.0981,2.6472,-5.9542,-0.979325828733772,7.11659934708321e-07,Benign,0.2598,benign,-2.986,available,https://doi.org/10.1101/2022.10.22.513328 +R209P,NP_000537:p.Arg209Pro,,,,,saturation_mutlist,,,,,,,,0.58089,0.1354735326766968,,1.5579584036605194,,1.0694242018302598,,Neutral,Neutral,,Neutral,0.34699735303987383,,0.8876581162203232,0.37183,,0.7799842876449742,,0.5759071438224871,,Neutral,,Neutral,,0.21322352733243327,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.2,2.6472,-1.0117,-0.0654921043241854,6.424467143987759e-11,Benign,0.1292,benign,-2.882,available,https://doi.org/10.1101/2022.10.22.513328 +R209Q,NP_000537:p.Arg209Gln,,,,,saturation_mutlist,,,,,,,,0.27627,0.04460044145584105,,0.5133364122016625,,0.39480320610083125,,Neutral,Neutral,,Neutral,0.08749280582184663,,0.21436625616230098,0.0704,,0.44142627544793206,,0.255913137723966,,Neutral,,Neutral,,0.1867321502769288,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.06,2.6472,-6.3692,-1.2587932454617,4.257629811391549e-07,Benign,0.0751,benign,-2.925,available,https://doi.org/10.1101/2022.10.22.513328 +R209S,NP_000537:p.Arg209Ser,"hg19,17:g.7578222T>A, hg19,17:g.7578222T>G, hg38,17:g.7674904T>A, hg38,17:g.7674904T>G",,,0.588,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2450746,Conflicting classifications of pathogenicity,1,,,,,0.50687,-0.07005996942520142,-0.25067666666666666,0.5679756393246375,0.1280966666666667,0.5374228196623188,Neutral,Neutral,Neutral,Neutral,Neutral,0.10739713080898942,0.16667621352657241,0.49442473047650787,0.31749,0.29501,0.3853679969481467,0.30625,0.3514289984740734,Neutral,Neutral,Neutral,Neutral,0.5516239775426736,0.22656535533555167,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.069,2.6472,-3.0716,-0.306108475250913,6.543326530673972e-11,Benign,0.1899,benign,-2.817,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R209T,NP_000537:p.Arg209Thr,"hg19,17:g.7578223C>G, hg38,17:g.7674905C>G",,,0.503,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.70734,-0.1391051983833313,-0.4960333333333333,0.5580021400047508,0.10565333333333332,0.6326710700023754,Neutral,Neutral,Neutral,Neutral,Neutral,0.09767205962829928,0.19745764209627903,0.40702912462504587,0.52916,0.21689333333333338,0.2774644610116831,0.3730266666666667,0.40331223050584153,Neutral,Neutral,Neutral,Neutral,0.4258359019100616,0.1244794317051676,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.0817,2.6472,-4.7063,-0.216224260209177,5.551231848561311e-11,Benign,0.1071,benign,-2.923,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R209V,NP_000537:p.Arg209Val,,,,,saturation_mutlist,,,,,,,,0.80489,0.06180526971817014,,0.4540317937126306,,0.6294608968563153,,Neutral,Neutral,,Neutral,0.08400360929254726,,0.17801198845643443,0.61644,,0.23198096685888525,,0.4242104834294426,,Neutral,,Neutral,,0.059170531624351284,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.1032,2.6472,-6.6322,-1.51509444997821,3.295707563919973e-07,Benign,0.1694,benign,-3.081,available,https://doi.org/10.1101/2022.10.22.513328 +R209W,NP_000537:p.Arg209Trp,,,,,saturation_mutlist,,,,,,,,0.41326,0.2305312943458557,,-0.012351164848484605,,0.20045441757575772,,Neutral,Neutral,,Neutral,0.14637010802719083,,0.22861630566190475,0.39051,,-0.22589613020970734,,0.08230693489514634,,Neutral,,Neutral,,0.16317458870588308,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.184,2.6472,-22.2419,-3.00918851809014,0.0569887881782419,Benign,0.1651,benign,-3.498,available,https://doi.org/10.1101/2022.10.22.513328 +R209Y,NP_000537:p.Arg209Tyr,,,,,saturation_mutlist,,,,,,,,0.28517,0.08684690952301026,,0.38160449995630213,,0.33338724997815106,,Neutral,Neutral,,Neutral,0.1621640505665139,,0.17169039164296557,0.13895,,0.13733582120230214,,0.13814291060115108,,Neutral,,Neutral,,0.07277133955901213,76.587,15.722,87.815,9.065,,True,76.587,,neutral,neutral,neutral,,True,87.815,,neutral,neutral,neutral,uncertain,,-0.12,2.6472,-8.9541,-2.17427921874393,8.179774195272651e-05,Benign,0.3116,benign,-3.21,available,https://doi.org/10.1101/2022.10.22.513328 +N210A,NP_000537:p.Asn210Ala,,,,,saturation_mutlist,,,,,,,,0.44158,0.07981933832168578,,0.17731294770795356,,0.3094464738539768,,Neutral,Neutral,,Neutral,0.09516089996456079,,0.07320321343754305,-0.17104,,0.019831519893427362,,-0.07560424005328632,,Neutral,,Neutral,,0.08725753042668875,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0329,2.3513,-6.6352,-2.03279374513134,3.8330661247911836e-07,Benign,0.1591,benign,-3.114,available,https://doi.org/10.1101/2022.10.22.513328 +N210C,NP_000537:p.Asn210Cys,,,,,saturation_mutlist,,,,,,,,0.5939,-0.20050616502761837,,0.7577424435338913,,0.6758212217669457,,Neutral,Neutral,,Neutral,0.06747959498650034,,0.06690424144600916,0.21272,,0.8053450586922685,,0.5090325293461342,,Neutral,,Neutral,,0.06037199818103462,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.1625,2.3513,-22.2448,-3.39086173782156,0.001282364372902,Benign,0.1937,benign,-3.56,available,https://doi.org/10.1101/2022.10.22.513328 +N210D,NP_000537:p.Asn210Asp,"hg38,17:g.7674903T>C",,,0.300,"COSMIC,saturation_mutlist",,,,,,,,0.33792,-0.0982698631286621,-0.25941,0.082376650978887,0.03925500000000001,0.2101483254894435,Neutral,Neutral,Neutral,Neutral,Neutral,0.04960407561960224,0.13765593509422927,0.10038602763589459,0.12608,-0.16938666666666666,-0.17446390832597727,-0.02165333333333333,-0.024191954162988638,Neutral,Neutral,Neutral,Neutral,0.07296914522971716,0.2535657227696408,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.048,2.3513,-8.957,-2.49788020409364,7.634782635466312e-06,Benign,0.1612,benign,-3.255,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N210E,NP_000537:p.Asn210Glu,,,,,saturation_mutlist,,,,,,,,0.07888,-0.1714367938041687,,-0.0006468712994489682,,0.039116564350275516,,Neutral,Neutral,,Neutral,0.10113986446834262,,0.12446444955909226,0.02636,,-0.2872624223860087,,-0.13045121119300435,,Neutral,,Neutral,,0.22747329224784554,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.1429,2.3513,-22.2448,-2.42513395189994,0.0001253550047578,Benign,0.2682,benign,-3.382,available,https://doi.org/10.1101/2022.10.22.513328 +N210F,NP_000537:p.Asn210Phe,,,,,saturation_mutlist,,,,,,,,-0.31832,0.1013903760910034,,-0.2367994640797316,,-0.2775597320398658,,Neutral,Neutral,,Neutral,0.08723521500265077,,0.12280699945778137,0.20808,,-0.011894041128967692,,0.09809297943551615,,Neutral,,Neutral,,0.19602087650585537,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0968,2.3513,-7.957,-2.09942827162007,1.030170708142118e-05,Benign,0.3628,ambiguous,-3.413,available,https://doi.org/10.1101/2022.10.22.513328 +N210G,NP_000537:p.Asn210Gly,,,,,saturation_mutlist,,,,,,,,0.19027,0.46904014229774477,,0.795258963553643,,0.49276448177682153,,Neutral,Neutral,,Neutral,0.09633793679525439,,0.012437839452365181,-0.61322,,0.5652754041987658,,-0.023972297900617112,,Neutral,,Neutral,,0.12728719529497856,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0654,2.3513,-6.9571,-2.44034244424212,1.7109610343255084e-05,Benign,0.2199,benign,-3.214,available,https://doi.org/10.1101/2022.10.22.513328 +N210H,NP_000537:p.Asn210His,"hg19,17:g.7578221T>G, hg38,17:g.7674903T>G",,,0.340,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.25484,-0.0029544234275817854,-0.07086333333333333,-0.20802349958987199,0.09198833333333334,0.023408250205064013,Neutral,Neutral,Neutral,Neutral,Neutral,0.07796495749462624,0.14105132312585925,0.10371961001099028,0.12517,0.16802666666666669,-0.23192920514278348,0.14659833333333333,-0.05337960257139174,Neutral,Neutral,Neutral,Neutral,0.0230991115750272,0.17161389844688105,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0245,2.3513,-4.0029,-0.502012353773146,3.1181353774420475e-08,Benign,0.0826,benign,-3.018,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N210I,NP_000537:p.Asn210Ile,,,,,saturation_mutlist,,,,,,,,0.1436,-0.04751974105834961,-0.52812,-0.15807780082905284,-0.19226000000000001,-0.00723890041452642,Neutral,Neutral,Neutral,Neutral,Neutral,0.12065767194631333,0.24037534080405723,0.1887779143201368,0.44984,-0.0051,-0.024802476345724234,0.22237,0.2125187618271379,Neutral,Neutral,Neutral,Neutral,0.017373498975930747,0.16769884750779532,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0555,2.3513,-1.2022,-0.131622522302542,1.7343403076458547e-09,Benign,0.1668,benign,-3.221,available,https://doi.org/10.1101/2022.10.22.513328 +N210K,NP_000537:p.Asn210Lys,"hg38,17:g.7674901G>C",,,0.369,"COSMIC,saturation_mutlist",,,,,,,,-0.27673,0.24767200231552125,-0.14297,0.00910656089065596,-0.20984999999999998,-0.133811719554672,Neutral,Neutral,Neutral,Neutral,Neutral,0.10248680556136519,0.13065516471485797,0.10035519618482595,-0.22058,-0.09206333333333332,-0.12532888410728263,-0.15632166666666666,-0.1729544420536413,Neutral,Neutral,Neutral,Neutral,0.025827542576783324,0.15154131938282542,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0429,2.3513,-7.957,-2.0116031568231,4.912733405455459e-08,Benign,0.2679,benign,-3.135,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N210L,NP_000537:p.Asn210Leu,,,,,saturation_mutlist,,,,,,,,-0.06161,0.07323698282241821,,-0.47759800575634176,,-0.2696040028781709,,Neutral,Neutral,,Neutral,0.06838505420618635,,0.09432491522435117,0.04572,,-0.2787557015187667,,-0.11651785075938337,,Neutral,,Neutral,,0.07842347311337852,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.1693,2.3513,-22.2448,-2.02846521268327,0.0018260787952334,Benign,0.1928,benign,-3.393,available,https://doi.org/10.1101/2022.10.22.513328 +N210M,NP_000537:p.Asn210Met,,,,,saturation_mutlist,,,,,,,,0.24903,0.1717099595069885,,-0.07647109496596304,,0.08627945251701849,,Neutral,Neutral,,Neutral,0.07265397614291855,,0.08146677669499013,0.04858,,0.002779659368652404,,0.0256798296843262,,Neutral,,Neutral,,0.1096270719691196,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0505,2.3513,-7.957,-1.03130203891255,0.0034282432000885,Benign,0.2232,benign,-3.504,available,https://doi.org/10.1101/2022.10.22.513328 +N210P,NP_000537:p.Asn210Pro,,,,,saturation_mutlist,,,,,,,,2.26112,1.2734072470664979,,3.5337605945868784,,2.897440297293439,,Uncertain,Uncertain,,Uncertain,0.2616366209114748,,1.3686647691315559,0.62682,,1.6958171677471017,,1.161318583873551,,Neutral,,Neutral,,0.43661916615336877,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.2782,2.3513,-22.2448,-4.60806841115371,0.0136408860526243,Benign,0.5182,ambiguous,-3.587,available,https://doi.org/10.1101/2022.10.22.513328 +N210Q,NP_000537:p.Asn210Gln,,,,,saturation_mutlist,,,,,,,,-0.15974,0.05750047206878661,,0.17955122932257775,,0.009905614661288878,,Neutral,Neutral,,Neutral,0.10452135011268734,,0.11428315679056573,-0.19573,,0.12150277757936183,,-0.03711361121031908,,Neutral,,Neutral,,0.15807245262266323,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0183,2.3513,-4.9571,-0.322259744734933,2.693877044529471e-09,Benign,0.1922,benign,-3.05,available,https://doi.org/10.1101/2022.10.22.513328 +N210R,NP_000537:p.Asn210Arg,,,,,saturation_mutlist,,,,,,,,-0.40359,0.18821251511573792,,-0.27224443758937994,,-0.33791721879468994,,Neutral,Neutral,,Neutral,0.1082857013713513,,0.13804048830535137,-0.40241,,-0.18177979029861324,,-0.29209489514930664,,Neutral,,Neutral,,0.09592318674529612,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0801,2.3513,-8.957,-2.27958977451338,4.216358282451287e-06,Benign,0.2681,benign,-3.292,available,https://doi.org/10.1101/2022.10.22.513328 +N210S,NP_000537:p.Asn210Ser,"hg19,17:g.7578220T>C, hg38,17:g.7674902T>C",,,0.262,"COSMIC,ClinVar,saturation_mutlist",3232058,Likely benign,1,,,,,0.01704,-0.06541111946105954,0.21303666666666665,0.31508833221550653,0.11503833333333333,0.16606416610775326,Neutral,Neutral,Neutral,Neutral,Neutral,0.05015111428698529,0.033443684339830464,0.03755846892139213,-0.06698,-0.23582666666666663,0.06163939645821364,-0.1514033333333333,-0.002670301770893179,Neutral,Neutral,Neutral,Neutral,0.07376687257088298,0.20697922080813938,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0028,2.3513,-6.6352,-1.6835745248611,4.888323316531231e-06,Benign,0.0892,benign,-2.958,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N210T,NP_000537:p.Asn210Thr,"hg38,17:g.7674902T>G",,,0.380,"COSMIC,saturation_mutlist",,,,,,,,-0.13568,-0.1887305474281311,-0.2899066666666667,0.1692000065310043,-0.21279333333333333,0.016760003265502157,Neutral,Neutral,Neutral,Neutral,Neutral,0.08439010239601756,0.20305899673630706,0.05858132373655761,-0.2299,-0.27857333333333334,0.0620314071655076,-0.25423666666666667,-0.0839342964172462,Neutral,Neutral,Neutral,Neutral,0.3283202179106381,0.14036309468090277,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0434,2.3513,-4.8696,-0.692090300639771,6.32499020050508e-12,Benign,0.0949,benign,-2.875,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N210V,NP_000537:p.Asn210Val,,,,,saturation_mutlist,,,,,,,,0.085,-0.19526052713394162,,-0.045739398388469264,,0.01963030080576537,,Neutral,Neutral,,Neutral,0.14950294144300272,,0.19295766670411654,0.56045,,0.03484019648504477,,0.2976450982425224,,Neutral,,Neutral,,0.09442043444176836,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0559,2.3513,-2.5996,-0.215895735946282,2.837682687204054e-09,Benign,0.1558,benign,-3.117,available,https://doi.org/10.1101/2022.10.22.513328 +N210W,NP_000537:p.Asn210Trp,,,,,saturation_mutlist,,,,,,,,0.08928,0.06259986639022826,,-0.5875402978616453,,-0.24913014893082264,,Neutral,Neutral,,Neutral,0.0942282823945343,,0.08019021175632197,0.30786,,-0.4182350845772307,,-0.05518754228861533,,Neutral,,Neutral,,0.25056704334526825,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.1748,2.3513,-22.2448,-3.30555446226139,0.0131709031662775,Benign,0.5747,pathogenic,-3.773,available,https://doi.org/10.1101/2022.10.22.513328 +N210Y,NP_000537:p.Asn210Tyr,"hg19,17:g.7578221T>A, hg38,17:g.7674903T>A",,,0.480,"ClinVar,saturation_mutlist",406588,Uncertain significance,1,,,,,-0.26416,0.044876241683959955,-0.57381,-0.18888817095484087,-0.41898500000000005,-0.22652408547742042,Neutral,Neutral,Neutral,Neutral,Neutral,0.1152110276230725,0.3706438039411964,0.08767642215097617,0.23591,0.01111,0.009833355842722344,0.12351000000000001,0.12287167792136118,Neutral,Neutral,Neutral,Neutral,0.15409378075271782,0.20547670264756382,76.947,14.22,112.075,8.676,,True,76.947,,neutral,neutral,neutral,,True,112.075,,neutral,neutral,neutral,uncertain,,-0.0855,2.3513,-8.957,-2.09316774390548,9.541986785072648e-05,Benign,0.1341,benign,-3.359,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T211A,NP_000537:p.Thr211Ala,"hg19,17:g.7578218T>C, hg19,17:g.7674900T>C, hg38,17:g.7674900T>C",,,0.881,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406581,Uncertain significance,2,,,,,0.00559,1.2753049159049987,1.33356,0.3440933074599804,0.669575,0.1748416537299902,Neutral,Neutral,Uncertain,Neutral,Neutral,0.5250001891584917,0.3029056355808961,0.2486342034987836,-0.64867,0.25827666666666665,0.27483131511323416,-0.19519666666666666,-0.1869193424433829,Neutral,Neutral,Neutral,Neutral,0.23535171316327588,0.11796099929033313,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.2295,0.2778,-8.957,-3.63665144001085,0.1301048823195264,Benign,0.7434,pathogenic,-3.762,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T211C,NP_000537:p.Thr211Cys,,,,,saturation_mutlist,,,,,,,,0.11141,0.8048892259597779,,0.7916455141074596,,0.45152775705372983,,Neutral,Neutral,,Neutral,0.47758248382651713,,0.1380632128211198,-0.43754,,0.6818170947759555,,0.12213854738797777,,Neutral,,Neutral,,0.17674150886520357,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.3331,0.2778,-22.2448,-4.47471510869345,0.8579282151730939,Pathogenic,0.8913,pathogenic,-4.268,available,https://doi.org/10.1101/2022.10.22.513328 +T211D,NP_000537:p.Thr211Asp,,,,,saturation_mutlist,,,,,,,,0.6632,0.8853811621665955,,0.6875719289494148,,0.6753859644747073,,Neutral,Neutral,,Neutral,0.467805969503151,,0.4128303372296043,-0.62753,,0.29756418978128857,,-0.16498290510935573,,Neutral,,Neutral,,0.4767530934546142,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.4128,0.2778,-22.2448,-5.07098938034153,0.2536633758838417,Benign,0.8989,pathogenic,-3.962,available,https://doi.org/10.1101/2022.10.22.513328 +T211E,NP_000537:p.Thr211Glu,,,,,saturation_mutlist,,,,,,,,0.54193,1.2013694095611571,,0.5888811048896745,,0.5654055524448373,,Neutral,Uncertain,,Neutral,0.5898888759134214,,0.5810459489103386,-0.19071,,0.20996323671340478,,0.009626618356702393,,Neutral,,Neutral,,0.4343700621535392,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.3882,0.2778,-22.2448,-5.1916988786315,0.6397260560465343,Uncertain,0.9739,pathogenic,-4.104,available,https://doi.org/10.1101/2022.10.22.513328 +T211F,NP_000537:p.Thr211Phe,,,,,saturation_mutlist,,,,,,,,0.01103,1.2100733757019042,,-0.1668502414612875,,-0.07791012073064374,,Neutral,Uncertain,,Neutral,0.6301516706086693,,0.2720312621676267,-0.92793,,-0.5406989364424503,,-0.7343144682212251,,Neutral,,Neutral,,0.0783469627741793,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.4045,0.2778,-22.2448,-7.44728783945904,0.8514161023670177,Pathogenic,0.9679,pathogenic,-4.411,available,https://doi.org/10.1101/2022.10.22.513328 +T211G,NP_000537:p.Thr211Gly,,,,,saturation_mutlist,,,,,,,,0.36033,1.3018962991237641,,1.196619729112823,,0.7784748645564116,,Neutral,Uncertain,,Neutral,0.5010047361841228,,0.28689409348756395,-0.21771,,1.1307365165654881,,0.4565132582827441,,Neutral,,Neutral,,0.16304512518482903,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.3707,0.2778,-22.2448,-6.26045786165554,0.2953157869212688,Benign,0.6999,pathogenic,-3.956,available,https://doi.org/10.1101/2022.10.22.513328 +T211H,NP_000537:p.Thr211His,,,,,saturation_mutlist,,,,,,,,0.42776,0.9815034651756287,,0.03265698262617226,,0.23020849131308613,,Neutral,Neutral,,Neutral,0.5151696100436075,,0.2874345435876011,0.08217,,-0.33099727282498637,,-0.12441363641249317,,Neutral,,Neutral,,0.22269568510390475,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.3848,0.2778,-22.2448,-7.44728783945904,0.7972528632017819,Pathogenic,0.8303,pathogenic,-4.263,available,https://doi.org/10.1101/2022.10.22.513328 +T211I,NP_000537:p.Thr211Ile,"hg19,17:g.7578217G>A, hg19,17:g.7674899G>A, hg38,17:g.7674899G>A",,,0.944,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1503185,Conflicting classifications of pathogenicity,1,,,,,0.27526,1.370404143333435,1.1818600000000001,-0.12964431514202046,0.7285600000000001,0.07280784242898977,Neutral,Neutral,Uncertain,Neutral,Neutral,0.5933910079396881,0.6600247168604118,0.22107464627059045,0.0779,-0.46904666666666667,-0.4157762948021177,-0.19557333333333332,-0.16893814740105884,Neutral,Neutral,Neutral,Neutral,0.5535091594745495,0.3326667510328717,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.2502,0.2778,-7.957,-4.64531106592155,0.5664694894743243,Uncertain,0.974,pathogenic,-3.921,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T211K,NP_000537:p.Thr211Lys,,,,,saturation_mutlist,,,,,,,,-0.34438,1.3823820900917054,,0.367909573326956,,0.011764786663477994,,Neutral,Uncertain,,Neutral,0.5791070820538914,,0.4667797243533399,-0.62265,,0.24661143932116925,,-0.1880192803394154,,Neutral,,Neutral,,0.31747599899924156,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.3075,0.2778,-7.957,-6.6999976599105,0.6356356111825094,Uncertain,0.9501,pathogenic,-4.088,available,https://doi.org/10.1101/2022.10.22.513328 +T211L,NP_000537:p.Thr211Leu,,,,,saturation_mutlist,,,,,,,,-0.46612,1.2354574632644653,,-0.3207660458494637,,-0.3934430229247319,,Neutral,Uncertain,,Neutral,0.5885161109535169,,0.16427465247014048,-0.57778,,-0.5547521434601975,,-0.5662660717300987,,Neutral,,Neutral,,0.2059239616975985,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.3073,0.2778,-8.957,-6.80110770447663,0.8346942566966367,Pathogenic,0.825,pathogenic,-4.284,available,https://doi.org/10.1101/2022.10.22.513328 +T211M,NP_000537:p.Thr211Met,,,,,saturation_mutlist,,,,,,,,-0.35807,1.3178615593910217,,0.04352585121043897,,-0.15727207439478053,,Neutral,Uncertain,,Neutral,0.5508262008428638,,0.1169794373508282,-0.67256,,-0.20260049770523367,,-0.43758024885261687,,Neutral,,Neutral,,0.15756630675975136,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.2742,0.2778,-8.957,-5.06572058813004,0.8621278205364444,Pathogenic,0.8022,pathogenic,-4.136,available,https://doi.org/10.1101/2022.10.22.513328 +T211N,NP_000537:p.Thr211Asn,"hg19,17:g.7578217G>T, hg38,17:g.7674899G>T",,,0.756,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.06181,0.660936815738678,0.6613366666666666,0.23212042536360533,0.3615733333333333,0.14696521268180265,Neutral,Neutral,Neutral,Neutral,Neutral,0.37447039077449035,0.3208919968185904,0.15280416735011207,-0.49277,0.08412666666666667,0.1065991329450457,-0.20432166666666665,-0.19308543352747715,Neutral,Neutral,Neutral,Neutral,0.3386951637616864,0.3123079162873579,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.28,0.2778,-7.957,-3.54541722447446,0.0007822012930365,Benign,0.4866,ambiguous,-3.559,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T211P,NP_000537:p.Thr211Pro,"hg19,17:g.7578218T>G, hg38,17:g.7674900T>G",,,0.911,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528235,Conflicting classifications of pathogenicity,1,,,,,1.72944,1.8787484884262085,6.507143333333334,4.444190184512563,4.118291666666667,3.086815092256282,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.47881891044649466,0.5044943298216764,0.8833433328155499,1.45357,5.398413333333334,2.658519630919851,3.425991666666667,2.0560448154599253,Uncertain,Uncertain,Destabilizing,Uncertain,0.5610556197225209,0.7093867936454634,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.4616,0.2778,-22.2448,-7.44728783945904,0.8541266949452736,Pathogenic,0.8468,pathogenic,-4.228,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T211Q,NP_000537:p.Thr211Gln,,,,,saturation_mutlist,,,,,,,,-0.11163,1.3067380499839782,,0.4262795871913232,,0.1573247935956616,,Neutral,Uncertain,,Neutral,0.544795680110757,,0.1645401794129683,-0.40316,,0.20409814701032722,,-0.0995309264948364,,Neutral,,Neutral,,0.2124536792940832,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.3623,0.2778,-22.2448,-5.68521728352499,0.5987545169213044,Uncertain,0.9286,pathogenic,-4.187,available,https://doi.org/10.1101/2022.10.22.513328 +T211R,NP_000537:p.Thr211Arg,,,,,saturation_mutlist,,,,,,,,-0.24265,1.312183485031128,,-0.033977652017828465,,-0.13831382600891423,,Neutral,Uncertain,,Neutral,0.5033729444379736,,0.3512992429923013,-0.56494,,-0.15854657974088412,,-0.3617432898704421,,Neutral,,Neutral,,0.19595549357998196,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.3154,0.2778,-8.957,-7.1973112402619,0.6868979991362969,Pathogenic,0.9114,pathogenic,-4.18,available,https://doi.org/10.1101/2022.10.22.513328 +T211S,NP_000537:p.Thr211Ser,"hg19,17:g.7578217G>C, hg38,17:g.7674899G>C",,,0.753,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1019369,Uncertain significance,1,,,,,-0.15226,0.47298547983169553,0.8225633333333334,0.6633232427556713,0.33515166666666674,0.2555316213778357,Neutral,Neutral,Neutral,Neutral,Neutral,0.180734804759466,0.2796679200210294,0.24263728965567996,-0.47663,0.6515833333333333,0.3824172044480448,0.08747666666666665,-0.04710639777597761,Neutral,Neutral,Neutral,Neutral,0.18336156364468048,0.1956829857802049,41.815,16.934,26.095,14.907,P,True,41.815,3.104,neutral,damaging,potentially_damaging,P,True,26.095,1.861,neutral,neutral,potentially_damaging,uncertain,,-0.1813,0.2778,-6.6352,-2.18720541797429,0.0001851706845794,Benign,0.295,benign,-3.296,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T211V,NP_000537:p.Thr211Val,,,,,saturation_mutlist,,,,,,,,0.44888,1.244421956539154,,-0.09536232010841644,,0.17675883994579178,,Neutral,Uncertain,,Neutral,0.5601747131709792,,0.17862645952962197,-0.38098,,-0.35874332742429726,,-0.3698616637121486,,Neutral,,Neutral,,0.27078059046179687,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.3107,0.2778,-22.2448,-6.80110770447663,0.8055839231342669,Pathogenic,0.9285,pathogenic,-4.154,available,https://doi.org/10.1101/2022.10.22.513328 +T211W,NP_000537:p.Thr211Trp,,,,,saturation_mutlist,,,,,,,,1.25394,1.1507693862915038,,-0.5517852549167542,,0.3510773725416229,,Neutral,Uncertain,,Neutral,0.5651674329662378,,0.3800004159032648,-0.00499,,-0.883453909090563,,-0.4442219545452815,,Neutral,,Neutral,,0.025906269021548935,41.815,16.934,26.095,14.907,P,True,41.815,3.104,damaging,damaging,potentially_damaging,P,True,26.095,1.861,damaging,neutral,potentially_damaging,uncertain,,-0.3974,0.2778,-22.2448,-7.44728783945904,0.8628402744723712,Pathogenic,0.9808,pathogenic,-4.653,available,https://doi.org/10.1101/2022.10.22.513328 +T211Y,NP_000537:p.Thr211Tyr,,,,,saturation_mutlist,,,,,,,,0.49134,1.0653728818893433,,-0.050685962205364234,,0.22032701889731787,,Neutral,Uncertain,,Neutral,0.6120174990684342,,0.3661491100458443,-0.74474,,-0.4459974889565001,,-0.5953687444782501,,Neutral,,Neutral,,0.09061206091653687,41.815,16.934,26.095,14.907,P,True,41.815,3.104,uncertain,damaging,potentially_damaging,P,True,26.095,1.861,uncertain,neutral,potentially_damaging,uncertain,,-0.406,0.2778,-22.2448,-7.44728783945904,0.858904709167525,Pathogenic,0.9436,pathogenic,-4.476,available,https://doi.org/10.1101/2022.10.22.513328 +F212A,NP_000537:p.Phe212Ala,,,,,saturation_mutlist,,,,,,,,0.9412,1.2711562967300416,,1.3539493219774394,,1.1475746609887199,,Neutral,Uncertain,,Neutral,0.5322941538306307,,0.7146853228978347,0.67906,,2.076881006195229,,1.3779705030976146,,Uncertain,,Neutral,,0.3218420166645428,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.2052,1.9157,-8.9482,-3.49317891176425,0.0076086523547026,Benign,0.537,ambiguous,-3.37,available,https://doi.org/10.1101/2022.10.22.513328 +F212C,NP_000537:p.Phe212Cys,"hg19,17:g.7578214A>C",,,0.647,"cBioPortal,saturation_mutlist",,,,,,,,0.80575,0.4362193536758423,1.8588466666666665,1.805994571369789,1.3322983333333331,1.3058722856848943,Neutral,Neutral,Neutral,Neutral,Neutral,0.420646754221029,0.28363647089579686,0.6433839934605337,0.68095,1.6327666666666667,2.4297937995462804,1.1568583333333333,1.5553718997731403,Neutral,Uncertain,Neutral,Neutral,0.531607406603365,0.31796785953295387,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.2412,1.9157,-22.2361,-2.86385680802714,0.0193908215630697,Benign,0.2408,benign,-3.434,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F212D,NP_000537:p.Phe212Asp,,,,,saturation_mutlist,,,,,,,,1.28356,1.7785703134536743,,1.5486315121101732,,1.4160957560550866,,Neutral,Uncertain,,Neutral,0.4850262044349729,,0.7860359407919187,1.40112,,2.573188013829414,,1.987154006914707,,Uncertain,,Neutral,,0.5052189394343242,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.396,1.9157,-22.2361,-3.96301967086493,0.0025305745381395,Benign,0.7937,pathogenic,-3.337,available,https://doi.org/10.1101/2022.10.22.513328 +F212E,NP_000537:p.Phe212Glu,,,,,saturation_mutlist,,,,,,,,1.12314,1.8411723709106445,,1.2980794429540572,,1.2106097214770286,,Neutral,Uncertain,,Neutral,0.39823778828038436,,0.7511362379065986,1.00698,,2.2982407112475784,,1.6526103556237892,,Uncertain,,Neutral,,0.5692201520694072,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.3654,1.9157,-22.2361,-3.46828654794656,0.0001336452853839,Benign,0.8186,pathogenic,-3.232,available,https://doi.org/10.1101/2022.10.22.513328 +F212G,NP_000537:p.Phe212Gly,,,,,saturation_mutlist,,,,,,,,-0.12605,0.9073358750343323,,2.0184113787366833,,0.9461806893683417,,Uncertain,Neutral,,Neutral,0.8207788425376422,,0.8183078687249468,1.06907,,3.185472182963354,,2.127271091481677,,Uncertain,,Uncertain,,0.442342820655794,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.1989,1.9157,-0.7885,-1.23932658021379,4.6690894306936085e-09,Benign,0.5,ambiguous,-2.984,available,https://doi.org/10.1101/2022.10.22.513328 +F212H,NP_000537:p.Phe212His,,,,,saturation_mutlist,,,,,,,,0.90373,0.6155000281333923,,0.5275585943470736,,0.7156442971735368,,Neutral,Neutral,,Neutral,0.34552938365482394,,0.5988902344507374,1.0242,,1.1736119973149484,,1.0989059986574743,,Neutral,,Neutral,,0.14583832264750468,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.2196,1.9157,-6.3634,-1.80709460931218,2.015694296748125e-06,Benign,0.4346,ambiguous,-3.046,available,https://doi.org/10.1101/2022.10.22.513328 +F212I,NP_000537:p.Phe212Ile,"hg19,17:g.7578215A>T, hg38,17:g.7674897A>T",,,0.478,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",422414,Uncertain significance,2,,,,,2.9213,1.5684529781341552,5.835263333333334,1.0065336949616592,4.378281666666667,1.9639168474808297,Uncertain,Uncertain,Uncertain,Destabilizing,Neutral,0.3048063948923984,0.32586057349049685,0.541206162787514,0.23843,1.79558,1.054425771154129,1.017005,0.6464278855770644,Neutral,Neutral,Neutral,Neutral,2.132155674538486,0.4820683450529506,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.2169,1.9157,-22.2361,-4.32079728589621,0.085619917219647,Benign,0.5688,pathogenic,-3.651,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F212K,NP_000537:p.Phe212Lys,,,,,saturation_mutlist,,,,,,,,0.27306,1.0579617810249329,,1.0922538899761867,,0.6826569449880934,,Neutral,Uncertain,,Neutral,0.7077857168863676,,0.8742196417970133,0.55176,,1.8978348332286405,,1.2247974166143203,,Neutral,,Neutral,,0.4626638661666243,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.2735,1.9157,-2.8823,-1.10700804156014,3.6814305186260638e-09,Benign,0.6899,pathogenic,-3.082,available,https://doi.org/10.1101/2022.10.22.513328 +F212L,NP_000537:p.Phe212Leu,"hg38,17:g.7674895A>T, hg38,17:g.7674897A>G",,,"0.481, 0.489","COSMIC,saturation_mutlist",,,,,,,,0.19846,0.7263230323791504,1.62744,0.4403618179826658,0.91295,0.3194109089913329,Neutral,Neutral,Neutral,Neutral,Neutral,0.49321679510361577,0.3639119951306909,0.5067181471150604,-0.12479,1.0341266666666666,0.5051856915109677,0.45466833333333334,0.19019784575548385,Neutral,Neutral,Neutral,Neutral,0.7693725506902073,0.10492932339413032,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.0885,1.9157,-4.4889,-1.03107939841147,8.233454131979605e-10,Benign,0.7743,pathogenic,-2.811,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F212M,NP_000537:p.Phe212Met,,,,,saturation_mutlist,,,,,,,,0.02649,0.8347103500366211,,0.7376895831453282,,0.3820897915726641,,Neutral,Neutral,,Neutral,0.44312969761115023,,0.4956375281004177,-0.01744,,0.9323242424047322,,0.4574421212023661,,Neutral,,Neutral,,0.16492478555809223,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.2101,1.9157,-22.2361,-1.43406472192369,0.000145070842239,Benign,0.5365,ambiguous,-3.186,available,https://doi.org/10.1101/2022.10.22.513328 +F212N,NP_000537:p.Phe212Asn,,,,,saturation_mutlist,,,,,,,,0.52058,1.1211274981498718,,1.176124963600734,,0.848352481800367,,Neutral,Uncertain,,Neutral,0.5719673412454621,,0.7798280309056637,0.80814,,1.9895748111662126,,1.3988574055831062,,Neutral,,Neutral,,0.328033703636591,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.2578,1.9157,-8.9482,-2.54237283675409,8.331946545718333e-06,Benign,0.5446,ambiguous,-3.117,available,https://doi.org/10.1101/2022.10.22.513328 +F212P,NP_000537:p.Phe212Pro,,,,,saturation_mutlist,,,,,,,,5.48629,1.770030915737152,,4.7088641036190095,,5.097577051809505,,Destabilizing,Uncertain,,Destabilizing,0.4203012321885084,,1.575409602053363,0.61769,,4.635351102413334,,2.6265205512066667,,Uncertain,,Uncertain,,2.884315526065018,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.3964,1.9157,-22.2361,-5.67218011770721,0.0833344152654177,Benign,0.9791,pathogenic,-3.692,available,https://doi.org/10.1101/2022.10.22.513328 +F212Q,NP_000537:p.Phe212Gln,,,,,saturation_mutlist,,,,,,,,0.83999,1.1678066444396973,,1.2251667222170541,,1.032578361108527,,Neutral,Uncertain,,Neutral,0.5636253478379322,,0.7167139079267558,0.88969,,1.9158462235272313,,1.4027681117636157,,Neutral,,Neutral,,0.32821564400607073,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.248,1.9157,-6.6264,-2.12549553303747,3.4429228118593344e-06,Benign,0.5769,pathogenic,-3.017,available,https://doi.org/10.1101/2022.10.22.513328 +F212R,NP_000537:p.Phe212Arg,,,,,saturation_mutlist,,,,,,,,0.64666,0.9995013427734375,,0.8075861148765945,,0.7271230574382972,,Neutral,Neutral,,Neutral,0.6071528547071282,,0.7611073526155595,0.83516,,1.3212254733064837,,1.0781927366532418,,Neutral,,Neutral,,0.3791842160400336,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.2905,1.9157,-5.9484,-1.7046024386267,1.6834713372471627e-08,Benign,0.5296,ambiguous,-3.028,available,https://doi.org/10.1101/2022.10.22.513328 +F212S,NP_000537:p.Phe212Ser,"hg19,17:g.7578214A>G, hg38,17:g.7674896A>G",,,0.554,"COSMIC,ClinVar,saturation_mutlist",3460339,Likely benign,1,,,,,0.88412,1.440371789932251,2.2990933333333334,1.6840077873650994,1.5916066666666668,1.2840638936825497,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.5111777771674373,0.5938731961922138,0.8529463838166209,1.14654,1.8757366666666666,2.497778021110664,1.5111383333333333,1.822159010555332,Neutral,Uncertain,Neutral,Neutral,0.407976241165531,0.6272600145892147,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.1761,1.9157,-7.3634,-2.08927993166533,0.0005328419811119,Benign,0.3508,ambiguous,-3.119,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F212T,NP_000537:p.Phe212Thr,,,,,saturation_mutlist,,,,,,,,2.91487,1.6764794778823853,,1.572815868417744,,2.243842934208872,,Uncertain,Uncertain,,Uncertain,0.38416974018610806,,0.7717138156370198,0.87346,,2.037894488672072,,1.455677244336036,,Uncertain,,Neutral,,0.4637276957909147,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.2305,1.9157,-8.9482,-3.71022864896652,0.0004472734518521,Benign,0.6653,pathogenic,-3.168,available,https://doi.org/10.1101/2022.10.22.513328 +F212V,NP_000537:p.Phe212Val,"hg19,17:g.7578215A>C, hg38,17:g.7674897A>C",,,0.471,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.98437,1.6798785829544067,5.40635,1.1024556248174615,4.19536,2.043412812408731,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.3057331777530912,0.22380374929835292,0.6721788870027429,0.47328,2.1139466666666666,1.2339631327338656,1.2936133333333333,0.8536215663669328,Uncertain,Neutral,Neutral,Neutral,1.9849465023913255,0.4352740955837839,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,neutral,,-0.2113,1.9157,-22.2361,-4.32079728589621,0.1492406082977196,Benign,0.4369,ambiguous,-3.471,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F212W,NP_000537:p.Phe212Trp,,,,,saturation_mutlist,,,,,,,,0.65715,0.24224463939666743,,-0.2424940183547388,,0.2073279908226306,,Neutral,Neutral,,Neutral,0.22527830381454672,,0.18535044589344904,0.39247,,-0.04910894699640994,,0.17168052650179502,,Neutral,,Neutral,,0.22059988575463702,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,uncertain,,-0.1287,1.9157,-8.9482,-3.83745532613329,0.0605611702082683,Benign,0.501,ambiguous,-3.66,available,https://doi.org/10.1101/2022.10.22.513328 +F212Y,NP_000537:p.Phe212Tyr,"hg19,17:g.7578214A>T, hg38,17:g.7674896A>T",,,0.395,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.25014,0.14966655373573304,0.07006999999999998,0.02933896532186529,0.16010499999999997,0.13973948266093264,Neutral,Neutral,Neutral,Neutral,Neutral,0.20927769968381837,0.4538680386044678,0.16282950254768022,0.25619,-0.21871,0.393107985609221,0.018739999999999993,0.32464899280461046,Neutral,Neutral,Neutral,Neutral,0.2672846020006889,0.11631039891112163,40.666,17.77,38.615,15.938,,True,40.666,,neutral,neutral,neutral,,True,38.615,,neutral,neutral,neutral,uncertain,,-0.0852,1.9157,-6.6264,-1.08294441578119,0.0147571010942062,Benign,0.135,benign,-3.244,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R213A,NP_000537:p.Arg213Ala,,,,,saturation_mutlist,,,,,,,,1.78027,0.7242279994487762,,1.607310003485536,,1.693790001742768,,Neutral,Neutral,,Neutral,0.43047278085050455,,0.25581480574305143,0.22713,,0.9964622683056582,,0.6117961341528291,,Neutral,,Neutral,,0.4349653398558779,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.3382,0.0421,-8.9482,-7.76858168299495,0.8708290226341315,Pathogenic,0.9985,pathogenic,-4.15,available,https://doi.org/10.1101/2022.10.22.513328 +R213C,NP_000537:p.Arg213Cys,,,,,saturation_mutlist,,,,,,,,1.69105,0.5068628311157226,,1.919809029858647,,1.8054295149293234,,Neutral,Neutral,,Neutral,0.504258893259505,,0.10109155726946083,-0.02771,,1.5422310220241735,,0.7572605110120868,,Neutral,,Neutral,,0.4242512315764734,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.4148,0.0421,-22.2361,-7.76858168299495,0.8052714141874626,Pathogenic,0.9587,pathogenic,-4.16,available,https://doi.org/10.1101/2022.10.22.513328 +R213D,NP_000537:p.Arg213Asp,,,,,saturation_mutlist,,,,,,,,2.95505,1.2800771009922027,,2.4241815739863912,,2.689615786993196,,Uncertain,Uncertain,,Uncertain,0.5416656661874654,,0.1214087346927402,1.62458,,1.4925574319544648,,1.5585687159772323,,Neutral,,Neutral,,0.4479295581472904,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.497,0.0421,-22.2361,-7.41214458829591,0.8708564673846064,Pathogenic,0.9993,pathogenic,-4.44,available,https://doi.org/10.1101/2022.10.22.513328 +R213E,NP_000537:p.Arg213Glu,,,,,saturation_mutlist,,,,,,,,2.37715,1.2164648270606995,,1.9827346211682133,,2.1799423105841065,,Uncertain,Uncertain,,Uncertain,0.5677065081482164,,0.015792171081433607,1.24627,,1.0039104677100135,,1.1250902338550066,,Neutral,,Neutral,,0.41602049930399243,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.4423,0.0421,-22.2361,-7.41214458829591,0.8437713597719634,Pathogenic,0.995,pathogenic,-4.419,available,https://doi.org/10.1101/2022.10.22.513328 +R213F,NP_000537:p.Arg213Phe,,,,,saturation_mutlist,,,,,,,,0.33223,0.42613872289657595,,-0.007442416189757596,,0.1623937919051212,,Neutral,Neutral,,Neutral,0.4950002654006165,,0.15663390933915705,1.15904,,0.3722206698818485,,0.7656303349409243,,Neutral,,Neutral,,0.3943622279419034,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.4381,0.0421,-22.2361,-6.5936364022848,0.8368836775222191,Pathogenic,0.9979,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +R213G,NP_000537:p.Arg213Gly,"hg19,17:g.7578212G>C, hg19,17:g.7674894G>C, hg38,17:g.7674894G>C",,,0.915,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376651,Conflicting classifications of pathogenicity,1,,,,,2.25236,0.8837440633773803,3.04354,2.848896837928095,2.64795,2.550628418964047,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.4526413038188448,0.3068354726342224,0.027610985503530625,0.74066,3.1356,2.0768567089571035,1.9381300000000001,1.4087583544785518,Uncertain,Uncertain,Neutral,Neutral,0.6103010093934522,0.5007615738444867,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.4413,0.0421,-22.2361,-8.03821593623277,0.865520093238438,Pathogenic,0.9955,pathogenic,-4.295,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R213H,NP_000537:p.Arg213His,,,,,saturation_mutlist,,,,,,,,1.79262,0.4937119960784912,,0.9927088859429828,,1.3926644429714914,,Neutral,Neutral,,Neutral,0.4265929417282976,,0.0686590123939739,1.68521,,0.7012421303374445,,1.1932260651687223,,Neutral,,Neutral,,0.4820669546772168,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.3757,0.0421,-22.2361,-5.86502111570081,0.186923686155542,Benign,0.9273,pathogenic,-3.62,available,https://doi.org/10.1101/2022.10.22.513328 +R213I,NP_000537:p.Arg213Ile,,,,,saturation_mutlist,,,,,,,,1.06251,0.8898485743999481,,0.43522185690982934,,0.7488659284549147,,Neutral,Neutral,,Neutral,0.5698679936716938,,0.4234029818768478,0.06605,,0.14771120126800263,,0.10688060063400132,,Neutral,,Neutral,,0.2771493663838392,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.4354,0.0421,-22.2361,-8.03821593623277,0.7920865083920613,Pathogenic,0.9971,pathogenic,-4.309,available,https://doi.org/10.1101/2022.10.22.513328 +R213K,NP_000537:p.Arg213Lys,,,,,saturation_mutlist,,,,,,,,1.10578,0.3381668245792389,,1.4279717079904115,,1.2668758539952059,,Neutral,Neutral,,Neutral,0.14271978530013807,,0.18124772142188422,0.11627,,0.8500651988404209,,0.4831675994202104,,Neutral,,Neutral,,0.485412629587876,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.2962,0.0421,-22.2361,-4.82659765217877,0.821986333859194,Pathogenic,0.9783,pathogenic,-3.972,available,https://doi.org/10.1101/2022.10.22.513328 +R213L,NP_000537:p.Arg213Leu,"hg19,17:g.7578211C>A, hg19,17:g.7674892_7674893delinsCA, hg19,17:g.7674893C>A, hg38,17:g.7674892_7674893delinsCA, hg38,17:g.7674893C>A",,,0.929,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376650,Conflicting classifications of pathogenicity,1,,,,,0.12978,0.5407968711853027,-0.18288000000000001,-0.15344285235400357,-0.026550000000000004,-0.01183142617700178,Neutral,Neutral,Neutral,Neutral,Neutral,0.505094284065432,0.43825109606251983,0.33229926892331835,-1.01042,0.18084,-0.15709333783689272,-0.41479000000000005,-0.5837566689184464,Neutral,Neutral,Neutral,Neutral,0.2588089376354688,0.27837924682366955,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.4084,0.0421,-22.2361,-8.03821593623277,0.8609277176067004,Pathogenic,0.9906,pathogenic,-4.104,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R213M,NP_000537:p.Arg213Met,,,,,saturation_mutlist,,,,,,,,-0.11109,0.5140597009658814,,0.4726771169079694,,0.1807935584539847,,Neutral,Neutral,,Neutral,0.4106892842470333,,0.25708537303249374,-1.1715,,0.3154107169710096,,-0.42804464151449517,,Neutral,,Neutral,,0.2898326926485503,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.3743,0.0421,-22.2361,-8.03821593623277,0.7771634233961031,Pathogenic,0.9991,pathogenic,-4.084,available,https://doi.org/10.1101/2022.10.22.513328 +R213N,NP_000537:p.Arg213Asn,,,,,saturation_mutlist,,,,,,,,2.001,0.7517289912700653,,1.5929663065745103,,1.796983153287255,,Uncertain,Neutral,,Neutral,0.4449227052698159,,0.23604259140088316,0.48169,,1.0050095569998232,,0.7433497784999116,,Neutral,,Neutral,,0.39736870067213814,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.4209,0.0421,-22.2361,-7.41214458829591,0.774929671814917,Pathogenic,0.9986,pathogenic,-4.085,available,https://doi.org/10.1101/2022.10.22.513328 +R213P,NP_000537:p.Arg213Pro,"hg19,17:g.7578211C>G, hg19,17:g.7674893C>G, hg38,17:g.7674893C>G",,,0.951,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",231214,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,5.50679,1.598562602996826,5.288889999999999,5.981990303813195,5.3978399999999995,5.744390151906597,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.477045942126205,1.5724027603002995,0.8222323771033119,5.74627,6.172906666666667,5.979240312849142,5.9595883333333335,5.862755156424571,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.4749812047041672,0.7610656427477349,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.5481,0.0421,-22.2361,-8.03821593623277,0.8630471616007978,Pathogenic,0.9986,pathogenic,-4.34,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R213Q,NP_000537:p.Arg213Gln,"hg19,17:g.7578210_7578211delinsCT, hg19,17:g.7578211C>T, hg19,17:g.7674893C>T, hg38,17:g.7674892_7674893delinsCT, hg38,17:g.7674893C>T",,3.9767440011e-06,0.920,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",135359,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,1.49254,0.6662465274333954,0.9538566666666667,1.3755479268299171,1.2231983333333334,1.4340439634149584,Neutral,Neutral,Neutral,Neutral,Neutral,0.3863106551189325,0.6269388496141833,0.195725340517069,0.27875,0.6366233333333333,0.8970510964809643,0.4576866666666667,0.5879005482404821,Neutral,Neutral,Neutral,Neutral,0.6597777814958271,0.370940652305685,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.3129,0.0421,-8.9482,-5.48929031422363,0.8249162635632338,Pathogenic,0.9561,pathogenic,-3.827,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R213S,NP_000537:p.Arg213Ser,,,,,saturation_mutlist,,,,,,,,2.30095,0.8178651070594788,,2.281515584958562,,2.2912327924792812,,Uncertain,Neutral,,Uncertain,0.4500032769997004,,0.19351941869185663,0.10179,,1.475591679778099,,0.7886908398890495,,Neutral,,Neutral,,0.5597122682675235,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.4065,0.0421,-22.2361,-7.76858168299495,0.8700925024565056,Pathogenic,0.9984,pathogenic,-4.16,available,https://doi.org/10.1101/2022.10.22.513328 +R213T,NP_000537:p.Arg213Thr,,,,,saturation_mutlist,,,,,,,,2.28168,0.8143023538589478,,1.731382796377125,,2.006531398188563,,Uncertain,Neutral,,Uncertain,0.5617718626892327,,0.15657525547615614,0.26932,,1.0029717742400595,,0.6361458871200297,,Neutral,,Neutral,,0.37012654544227225,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.4109,0.0421,-22.2361,-7.76858168299495,0.8475534069526093,Pathogenic,0.9986,pathogenic,-4.182,available,https://doi.org/10.1101/2022.10.22.513328 +R213V,NP_000537:p.Arg213Val,,,,,saturation_mutlist,,,,,,,,1.57749,0.8513926076889038,,0.7441033703344618,,1.160796685167231,,Neutral,Neutral,,Neutral,0.608705980759944,,0.4253858384354362,0.52153,,0.4202026762009609,,0.4708663381004805,,Neutral,,Neutral,,0.2876063326589535,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.4225,0.0421,-22.2361,-8.03821593623277,0.8705599875957521,Pathogenic,0.9976,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +R213W,NP_000537:p.Arg213Trp,"hg19,17:g.7578210_7578212delinsCCA, hg38,17:g.7674892_7674894delinsCCA",,,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3460335,Pathogenic,1,,,,,1.00914,0.38603380918502805,0.65068,0.05242613654006356,0.8299099999999999,0.5307830682700317,Neutral,Neutral,Neutral,Neutral,Neutral,0.5399619203956161,0.9462359870913104,0.14104085687541384,3.69944,0.40782333333333337,-0.04089414148763978,2.0536316666666665,1.8292729292561802,Uncertain,Uncertain,Uncertain,Neutral,0.9285728342043085,0.4161298630036656,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.4237,0.0421,-22.2361,-6.5936364022848,0.8394075372421022,Pathogenic,0.9479,pathogenic,-4.152,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R213Y,NP_000537:p.Arg213Tyr,,,,,saturation_mutlist,,,,,,,,0.99119,0.36089300632476806,,0.30179896416466157,,0.6464944820823308,,Neutral,Neutral,,Neutral,0.5861181023595037,,0.20554249874334268,3.20789,,0.5105383478345201,,1.85921417391726,,Uncertain,,Neutral,,0.4522359135796886,6.944,4.828,23.57,14.926,,True,6.944,,neutral,neutral,neutral,,True,23.57,,neutral,neutral,neutral,uncertain,,-0.4274,0.0421,-22.2361,-6.5936364022848,0.7928861798017692,Pathogenic,0.992,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328 +H214A,NP_000537:p.His214Ala,,,,,"COSMIC,saturation_mutlist",,,,,,,,0.03044,1.0919493293762208,1.10306,1.137267886241486,0.56675,0.583853943120743,Neutral,Neutral,Uncertain,Neutral,Neutral,0.43145473350495506,0.3854021746176323,0.3693883340350527,-1.36699,0.8781166666666667,1.3182949359388119,-0.24443666666666664,-0.024347532030594032,Neutral,Neutral,Neutral,Neutral,0.6556390582392791,0.57905536722876,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,neutral,,-0.2125,0.9192,-22.2419,-5.55656608914318,0.8341463212690233,Pathogenic,0.9728,pathogenic,-4.178,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214C,NP_000537:p.His214Cys,,,,,saturation_mutlist,,,,,,,,0.16703,0.46805318832397463,,1.5460910759637974,,0.8565605379818987,,Neutral,Neutral,,Neutral,0.2595165796209691,,0.2967470241105136,-1.47739,,1.703737092179467,,0.11317354608973351,,Neutral,,Neutral,,0.33682652298266985,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,neutral,,-0.267,0.9192,-22.2419,-5.24335004222305,0.3454336796092247,Uncertain,0.7867,pathogenic,-3.956,available,https://doi.org/10.1101/2022.10.22.513328 +H214D,NP_000537:p.His214Asp,"hg19,17:g.7578209G>C, hg38,17:g.7674891G>C",,,0.844,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.82548,1.4762108969688414,1.6244866666666666,1.5116712466880668,1.2249833333333333,1.1685756233440334,Neutral,Neutral,Uncertain,Neutral,Neutral,0.4687394136051625,0.9325762694933976,0.687723853534117,0.52636,2.93526,2.1233755035822885,1.73081,1.3248677517911442,Uncertain,Uncertain,Neutral,Neutral,0.6048079683668196,0.4799732442219689,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,neutral,,-0.2597,0.9192,-22.2419,-3.52139071132981,0.8580051769914587,Pathogenic,0.9861,pathogenic,-4.161,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214E,NP_000537:p.His214Glu,,,,,saturation_mutlist,,,,,,,,0.56159,1.6397368264198304,,1.1951681796587943,,0.8783790898293972,,Neutral,Uncertain,,Neutral,0.5361799275309662,,0.5540361055937457,0.52626,,1.8733008903829342,,1.199780445191467,,Neutral,,Neutral,,0.5498655905865314,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,neutral,,-0.2712,0.9192,-22.2419,-2.67614011798552,0.264674153989896,Benign,0.964,pathogenic,-3.795,available,https://doi.org/10.1101/2022.10.22.513328 +H214F,NP_000537:p.His214Phe,,,,,saturation_mutlist,,,,,,,,-1.21172,0.7352018594741822,,-0.10869042411514944,,-0.6602052120575747,,Neutral,Neutral,,Neutral,0.5336695813966856,,0.19565857903682976,0.69372,,0.20257006431370325,,0.44814503215685164,,Neutral,,Neutral,,0.463531659902586,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,uncertain,,-0.2341,0.9192,-22.2419,-3.84006568735445,0.4250087933533695,Uncertain,0.9313,pathogenic,-4.078,available,https://doi.org/10.1101/2022.10.22.513328 +H214G,NP_000537:p.His214Gly,,,,,saturation_mutlist,,,,,,,,0.44612,1.4433655190467833,,2.29316161771567,,1.3696408088578351,,Uncertain,Uncertain,,Neutral,0.56668829869874,,0.7078264465844564,-1.39814,,2.8945825055212233,,0.7482212527606117,,Uncertain,,Neutral,,0.4399029741287066,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,neutral,,-0.2951,0.9192,-22.2419,-6.13903125739984,0.7798925193016145,Pathogenic,0.9787,pathogenic,-4.209,available,https://doi.org/10.1101/2022.10.22.513328 +H214I,NP_000537:p.His214Ile,,,,,saturation_mutlist,,,,,,,,0.10058,1.613276731967926,,0.40057442834290846,,0.25057721417145423,,Neutral,Uncertain,,Neutral,0.6823593664196258,,0.16094865611348244,-1.32407,,0.19424038983056244,,-0.5649148050847188,,Neutral,,Neutral,,0.328373419241239,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,uncertain,,-0.2987,0.9192,-22.2419,-4.70255455261732,0.8602060636819979,Pathogenic,0.9923,pathogenic,-4.232,available,https://doi.org/10.1101/2022.10.22.513328 +H214K,NP_000537:p.His214Lys,,,,,saturation_mutlist,,,,,,,,0.11761,1.02162104845047,,1.077342166419988,,0.597476083209994,,Neutral,Uncertain,,Neutral,0.5931585237371994,,0.45904698280617323,-0.1051,,1.7640484320627337,,0.8294742160313668,,Neutral,,Neutral,,0.5694090420526555,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,uncertain,,-0.1876,0.9192,-8.9541,-3.56992154150808,0.2176804642261617,Benign,0.9667,pathogenic,-3.858,available,https://doi.org/10.1101/2022.10.22.513328 +H214L,NP_000537:p.His214Leu,"hg19,17:g.7578208T>A, hg38,17:g.7674890T>A",,,0.869,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376616,Likely pathogenic,3,,,,,-0.58342,1.294804880619049,-0.68186,0.016643002054861328,-0.6326400000000001,-0.28338849897256935,Neutral,Neutral,Uncertain,Neutral,Neutral,0.5787864486652741,0.412513647127785,0.2076968813214241,-2.02947,-0.5192733333333334,-0.055454860613861845,-1.2743716666666667,-1.042462430306931,Uncertain,Uncertain,Neutral,Neutral,0.7955892139512422,0.4006219132009257,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,uncertain,,-0.2623,0.9192,-22.2419,-3.80100244388362,0.0995391524206491,Benign,0.8,pathogenic,-3.753,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214M,NP_000537:p.His214Met,,,,,saturation_mutlist,,,,,,,,-0.88211,1.1858245539665222,,0.4666352404213701,,-0.20773737978931492,,Neutral,Uncertain,,Neutral,0.5871279263191221,,0.22576402498577874,-2.00779,,0.5370326492075693,,-0.7353786753962153,,Uncertain,,Neutral,,0.3946735835453708,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,uncertain,,-0.2124,0.9192,-22.2419,-3.87460467270577,0.1576713376386322,Benign,0.959,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328 +H214N,NP_000537:p.His214Asn,"hg19,17:g.7578209G>T, hg38,17:g.7674891G>T",,,0.735,"ClinVar,saturation_mutlist",230254,Uncertain significance,2,,,,,0.3636,0.38096670150756834,1.17415,1.14839157011002,0.768875,0.75599578505501,Neutral,Neutral,Neutral,Neutral,Neutral,0.46763004162172167,0.4990638554333503,0.43344115769726393,-0.97107,1.2276666666666667,1.270976600248675,0.12829833333333335,0.14995330012433755,Neutral,Neutral,Neutral,Neutral,0.40249522500963364,0.45108738521915903,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,neutral,,-0.2192,0.9192,-22.2419,-3.29554812010733,0.722255729522221,Pathogenic,0.8346,pathogenic,-3.844,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214P,NP_000537:p.His214Pro,"hg19,17:g.7578208T>G, hg38,17:g.7674890T>G",,0.0,0.932,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",643078,Uncertain significance,2,,,,,0.00632,1.510699782371521,1.9689333333333334,3.181529189848975,0.9876266666666668,1.5939245949244876,Neutral,Uncertain,Uncertain,Neutral,Neutral,0.8080413695221352,1.203477494716411,0.8535421435125237,-1.55738,1.7214299999999998,4.501419541012406,0.0820249999999999,1.4720197705062028,Neutral,Uncertain,Neutral,Neutral,0.33546408968273583,1.631180431322699,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,neutral,,-0.3757,0.9192,-22.2419,-6.13903125739984,0.8301338606677469,Pathogenic,0.9774,pathogenic,-4.11,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214Q,NP_000537:p.His214Gln,"hg19,17:g.7578207A>C, hg38,17:g.7674889A>C, hg38,17:g.7674889A>T",,3.18134459529e-05,0.550,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",140943,Conflicting classifications of pathogenicity,1,,,,,0.15857,1.1439590573310852,0.33401333333333333,1.04033084068915,0.24629166666666666,0.599450420344575,Neutral,Neutral,Uncertain,Neutral,Neutral,0.5356070463854707,0.43811875447442583,0.3843689756593047,-0.0542,0.6875300000000001,1.287543322955216,0.31666500000000003,0.616671661477608,Neutral,Neutral,Neutral,Neutral,0.47429534111142185,0.5255322595917237,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,neutral,,-0.0699,0.9192,-0.5196,-0.0842496993920413,6.364507416884325e-07,Benign,0.7704,pathogenic,-2.996,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214R,NP_000537:p.His214Arg,"hg19,17:g.7578208T>C, hg19,17:g.7674890T>C, hg38,17:g.7674890T>C",,,0.885,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376615,Pathogenic,3,Oncogenic,1,,,0.46028,0.7594877457618714,0.9887766666666667,0.629745526477529,0.7245283333333334,0.5450127632387645,Neutral,Neutral,Neutral,Neutral,Neutral,0.5439945170515679,0.8247681460197701,0.32807118547960895,1.53008,0.6005666666666667,1.2421011002858504,1.0653233333333334,1.3860905501429253,Neutral,Neutral,Neutral,Neutral,0.6152249037727766,0.4051748088813574,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,uncertain,,-0.2488,0.9192,-22.2419,-4.8374880537707,0.3910010095839695,Uncertain,0.9451,pathogenic,-3.856,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214S,NP_000537:p.His214Ser,,,,,saturation_mutlist,,,,,,,,0.67883,0.921010422706604,,1.6120012515896691,,1.1454156257948345,,Neutral,Neutral,,Neutral,0.5681600973208238,,0.598914177613535,-1.15188,,1.8893242288968672,,0.3687221144484336,,Neutral,,Neutral,,0.5295371839740289,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,neutral,,-0.2184,0.9192,-22.2419,-5.55656608914318,0.8660162688848886,Pathogenic,0.9557,pathogenic,-3.984,available,https://doi.org/10.1101/2022.10.22.513328 +H214T,NP_000537:p.His214Thr,,,,,saturation_mutlist,,,,,,,,0.93799,1.257909049987793,,1.1646852105829357,,1.0513376052914678,,Neutral,Uncertain,,Neutral,0.6347913275822379,,0.4206594411931942,-0.69921,,1.3355412669348758,,0.3181656334674379,,Neutral,,Neutral,,0.46301310061296524,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,neutral,,-0.1955,0.9192,-8.9541,-5.55656608914318,0.8622893384076964,Pathogenic,0.9916,pathogenic,-4.116,available,https://doi.org/10.1101/2022.10.22.513328 +H214V,NP_000537:p.His214Val,,,,,saturation_mutlist,,,,,,,,0.37496,1.4755379676818847,,0.5736101354164881,,0.4742850677082441,,Neutral,Uncertain,,Neutral,0.46586102172453303,,0.1744757909712017,-1.74345,,0.43012998468006053,,-0.6566600076599697,,Neutral,,Neutral,,0.23662515864164135,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,neutral,,-0.2551,0.9192,-22.2419,-4.70255455261732,0.8672932129288928,Pathogenic,0.9893,pathogenic,-4.203,available,https://doi.org/10.1101/2022.10.22.513328 +H214W,NP_000537:p.His214Trp,,,,,saturation_mutlist,,,,,,,,-0.29339,0.7484714794158935,,-0.2835788615437766,,-0.2884844307718883,,Neutral,Neutral,,Neutral,0.8187158545087586,,0.05989202345214756,5.25424,,0.41609378310539574,,2.835166891552698,,Uncertain,,Uncertain,,0.6319225141070037,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,uncertain,,-0.2504,0.9192,-22.2419,-4.03349708167166,0.8544198015878388,Pathogenic,0.948,pathogenic,-4.488,available,https://doi.org/10.1101/2022.10.22.513328 +H214Y,NP_000537:p.His214Tyr,"hg19,17:g.7578209G>A, hg19,17:g.7578209_7578210inv, hg38,17:g.7674891G>A, hg38,17:g.7674891_7674892inv",,,0.736,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","4530422, 1053808",Uncertain significance,3,,,Tier I - Strong,1,-0.47169,0.33878967761993406,-0.2621333333333334,0.07076352546410357,-0.3669116666666667,-0.2004632372679482,Neutral,Neutral,Neutral,Neutral,Neutral,0.5293362923677168,0.7620088774781798,0.18117745998578375,2.83107,-1.1028333333333333,0.6292165977321708,0.8641183333333333,1.7301432988660854,Uncertain,Uncertain,Neutral,Neutral,0.22663390219078483,0.6394037794666526,15.581,7.485,2.91,3.103,,True,15.581,,neutral,neutral,neutral,,True,2.91,,neutral,neutral,neutral,uncertain,,-0.1843,0.9192,-22.2419,-3.64208286680964,0.2021462130735969,Benign,0.8018,pathogenic,-3.735,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215A,NP_000537:p.Ser215Ala,,,,,saturation_mutlist,,,,,,,,-0.04804,0.029384682178497337,,-0.5115243651130897,,-0.27978218255654486,,Neutral,Neutral,,Neutral,0.3156412406113391,,0.2328546747417778,-0.0779,,-0.5091899137365105,,-0.2935449568682552,,Neutral,,Neutral,,0.3809556670722806,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,damaging,uncertain,uncertain,,-0.2731,0.0798,-22.2419,-4.73329170270735,0.7902628822701911,Pathogenic,0.6135,pathogenic,-3.662,available,https://doi.org/10.1101/2022.10.22.513328 +S215C,NP_000537:p.Ser215Cys,"hg19,17:g.7578206T>A, hg19,17:g.7674888T>A, hg38,17:g.7674888T>A",,,0.902,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1753522,Uncertain significance,2,,,,,-0.06553,-0.38963136553764344,0.27324333333333334,0.03385648327184853,0.10385666666666667,-0.015836758364075738,Neutral,Neutral,Neutral,Neutral,Neutral,0.29221414794058204,0.5427763711593282,0.22441523676177882,0.16185,-0.25827666666666665,-0.30164843593533885,-0.04821333333333333,-0.06989921796766943,Neutral,Neutral,Neutral,Neutral,0.13602665825328342,0.4211368864178069,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,damaging,uncertain,neutral,,-0.2558,0.0798,-8.9541,-2.10381058388002,0.1022355126315968,Benign,0.4744,ambiguous,-3.564,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215D,NP_000537:p.Ser215Asp,,,,,saturation_mutlist,,,,,,,,1.65061,1.5166045427322388,,0.1854488220749367,,0.9180294110374683,,Neutral,Uncertain,,Neutral,0.4084894593766313,,0.21393743106947719,2.45923,,0.4111048606817646,,1.4351674303408821,,Uncertain,,Neutral,,0.5072127703245192,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,uncertain,uncertain,neutral,,-0.3718,0.0798,-22.2419,-6.85173328607324,0.8670775833252734,Pathogenic,0.9952,pathogenic,-4.486,available,https://doi.org/10.1101/2022.10.22.513328 +S215E,NP_000537:p.Ser215Glu,,,,,saturation_mutlist,,,,,,,,1.58789,0.5093266147375107,,0.07566911715784162,,0.8317795585789208,,Neutral,Neutral,,Neutral,0.4690139689327588,,0.41040186763028175,1.32234,,0.011973239527320859,,0.6671566197636605,,Neutral,,Neutral,,0.3431735177978708,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,damaging,uncertain,neutral,,-0.345,0.0798,-22.2419,-5.87476269690066,0.8527333454847852,Pathogenic,0.9949,pathogenic,-4.413,available,https://doi.org/10.1101/2022.10.22.513328 +S215F,NP_000537:p.Ser215Phe,,,,,saturation_mutlist,,,,,,,,2.20522,-0.09705992460250855,,-0.5675814044804844,,0.8188192977597579,,Uncertain,Neutral,,Neutral,0.4903067227990576,,0.5458117301472105,6.71951,,-1.5719637659276984,,2.5737731170361506,,Uncertain,,Uncertain,,0.48436635807108364,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,uncertain,uncertain,P,True,3.95,4.058,uncertain,neutral,uncertain,neutral,,-0.3512,0.0798,-22.2419,-6.55283609753433,0.4609662213966627,Uncertain,0.9772,pathogenic,-4.029,available,https://doi.org/10.1101/2022.10.22.513328 +S215G,NP_000537:p.Ser215Gly,"hg19,17:g.7578206T>C, hg19,17:g.7674888T>C, hg38,17:g.7674888T>C",,,0.896,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",265337,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,1.06587,0.9896213054656983,1.6914966666666666,0.9139701056175839,1.3786833333333335,0.9899200528087919,Neutral,Neutral,Neutral,Neutral,Neutral,0.40235077353310883,0.391709474171299,0.1795857392496508,0.5698,0.27642,1.2695101720469093,0.42311,0.9196550860234547,Neutral,Neutral,Neutral,Neutral,0.3336615220049604,0.4034107729112126,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,damaging,uncertain,uncertain,destabilizing,-0.2823,0.0798,-22.2419,-7.88480027678971,0.8708084160401148,Pathogenic,0.8417,pathogenic,-4.104,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215H,NP_000537:p.Ser215His,,,,,saturation_mutlist,,,,,,,,3.35018,0.48789444446563723,,-0.4379812706699426,,1.4560993646650287,,Uncertain,Neutral,,Neutral,0.5137273812901858,,0.3227929770073015,7.0593,,-0.8951294857199189,,3.0820852571400406,,Uncertain,,Destabilizing,,0.5319692049364825,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,neutral,uncertain,P,True,3.95,4.058,uncertain,neutral,uncertain,neutral,,-0.3524,0.0798,-22.2419,-6.97005118812259,0.8684153550947646,Pathogenic,0.9567,pathogenic,-4.355,available,https://doi.org/10.1101/2022.10.22.513328 +S215I,NP_000537:p.Ser215Ile,"hg19,17:g.7578205C>A, hg19,17:g.7674887C>A, hg38,17:g.7674887C>A",,,0.913,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376660,Conflicting classifications of pathogenicity,1,,,,,-0.16331,-0.25130886197090146,0.3238133333333333,-0.29641199722876294,0.08025166666666664,-0.22986099861438147,Neutral,Neutral,Neutral,Neutral,Neutral,0.5255123366329018,2.069978714565818,0.7509788063115106,0.40486,0.3098666666666666,-1.6753502173896584,0.3573633333333333,-0.6352451086948292,Neutral,Neutral,Neutral,Neutral,1.266445001051719,0.0517659325631453,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,damaging,uncertain,neutral,uncertain,-0.3543,0.0798,-22.2419,-7.35595670390969,0.868254689160872,Pathogenic,0.984,pathogenic,-4.408,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215K,NP_000537:p.Ser215Lys,,,,,saturation_mutlist,,,,,,,,0.62493,0.7416496324539185,1.5681433333333334,0.8611600998984009,1.0965366666666667,0.7430450499492005,Neutral,Neutral,Neutral,Neutral,Neutral,0.48644804731407865,1.3785993765976958,0.6676691336776321,1.41964,1.1876433333333332,0.1692401406783761,1.3036416666666666,0.7944400703391881,Neutral,Neutral,Neutral,Neutral,0.10809163036773728,0.0623247719221744,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,damaging,uncertain,neutral,,-0.3618,0.0798,-22.2419,-7.88480027678971,0.8702193250299106,Pathogenic,0.9993,pathogenic,-4.554,available,https://doi.org/10.1101/2022.10.22.513328 +S215L,NP_000537:p.Ser215Leu,,,,,saturation_mutlist,,,,,,,,-0.31689,0.27960870623588563,,-0.5012555630343346,,-0.4090727815171673,,Neutral,Neutral,,Neutral,0.48935168891618397,,0.5611608760436599,-0.57755,,-1.8416554206052276,,-1.209602710302614,,Neutral,,Neutral,,0.10177127768265481,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,damaging,uncertain,neutral,,-0.3506,0.0798,-22.2419,-7.35595670390969,0.8707605326470282,Pathogenic,0.9553,pathogenic,-4.37,available,https://doi.org/10.1101/2022.10.22.513328 +S215M,NP_000537:p.Ser215Met,,,,,saturation_mutlist,,,,,,,,-0.81735,0.024463073015213027,,-0.42852011782552285,,-0.6229350589127615,,Neutral,Neutral,,Neutral,0.3909890613633744,,0.4820655810214925,-0.84883,,-1.3643692966928445,,-1.1065996483464222,,Neutral,,Neutral,,0.22864808375124962,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,damaging,uncertain,neutral,,-0.2487,0.0798,-7.9541,-5.23075562451699,0.8044155618922085,Pathogenic,0.9306,pathogenic,-4.192,available,https://doi.org/10.1101/2022.10.22.513328 +S215N,NP_000537:p.Ser215Asn,"hg19,17:g.7578205C>T, hg19,17:g.7674887C>T, hg38,17:g.7674887C>T",,,0.785,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376662,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,1.22209,1.09413055062294,0.9053300000000001,-0.18146014632068622,1.06371,0.5203149268396569,Neutral,Neutral,Uncertain,Neutral,Neutral,0.45582837830463857,0.589372506484651,0.09100771283781864,1.91602,0.74433,-0.4571012762631194,1.330175,0.7294593618684403,Neutral,Neutral,Neutral,Neutral,0.16993073667428937,0.39131941687050403,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,damaging,uncertain,neutral,,-0.2955,0.0798,-22.2419,-5.85983530296452,0.5302654752351877,Uncertain,0.9616,pathogenic,-3.858,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215P,NP_000537:p.Ser215Pro,,,,,saturation_mutlist,,,,,,,,2.84942,1.715186927318573,,4.362254046258738,,3.605837023129369,,Uncertain,Uncertain,,Destabilizing,1.0621586423929488,,1.230535498717344,4.11098,,2.83929403587234,,3.47513701793617,,Uncertain,,Destabilizing,,1.094849754806487,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,uncertain,uncertain,P,True,3.95,4.058,uncertain,neutral,uncertain,neutral,,-0.3588,0.0798,-8.9541,-7.88480027678971,0.857492124739714,Pathogenic,0.9993,pathogenic,-4.414,available,https://doi.org/10.1101/2022.10.22.513328 +S215Q,NP_000537:p.Ser215Gln,,,,,saturation_mutlist,,,,,,,,0.73156,0.4711938500404358,,0.005201537681323208,,0.3683807688406616,,Neutral,Neutral,,Neutral,0.4121542674106049,,0.4385815696203583,0.95898,,-0.6146865953178499,,0.1721467023410751,,Neutral,,Neutral,,0.3762226232557912,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,damaging,uncertain,neutral,,-0.3151,0.0798,-22.2419,-6.85173328607324,0.8604222736812217,Pathogenic,0.9858,pathogenic,-4.409,available,https://doi.org/10.1101/2022.10.22.513328 +S215R,NP_000537:p.Ser215Arg,"hg19,17:g.7578204A>C, hg19,17:g.7578204A>T, hg19,17:g.7578206T>G, hg19,17:g.7674886A>C, hg19,17:g.7674886A>T, hg19,17:g.7674888T>G, hg38,17:g.7674886A>C, hg38,17:g.7674886A>T, hg38,17:g.7674888T>G",,,"0.812, 0.917","cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","2020649, 428895, 376661","Conflicting classifications of pathogenicity, Conflicting classifications of pathogenicity, Conflicting classifications of pathogenicity","1, 1, 1",Oncogenic,1,,,0.84256,0.6160008609294891,1.4622466666666665,0.08750885531328635,1.1524033333333332,0.46503442765664316,Neutral,Neutral,Neutral,Neutral,Neutral,0.4783188821009404,0.4658964460287524,0.40102206263445456,2.11402,0.67041,-0.6792359365598286,1.392215,0.7173920317200857,Uncertain,Uncertain,Neutral,Neutral,0.5289651572646349,0.22547937520079603,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,uncertain,uncertain,neutral,stabilizing,-0.367,0.0798,-22.2419,-7.88480027678971,0.8702514428238202,Pathogenic,0.998,pathogenic,-4.477,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215T,NP_000537:p.Ser215Thr,"hg19,17:g.7578205C>G, hg19,17:g.7674887C>G, hg38,17:g.7674887C>G",,,0.852,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142012,Conflicting classifications of pathogenicity,1,,,,,0.41074,-0.08223286509513854,0.16961666666666667,-0.2932535328754299,0.2901783333333333,0.05874323356228506,Neutral,Neutral,Neutral,Neutral,Neutral,0.3017476978915627,0.4366220804718373,0.16722380051377275,0.77502,-0.038773333333333326,-0.5783864415627552,0.36812333333333336,0.09831677921862242,Neutral,Neutral,Neutral,Neutral,0.5748471265958939,0.27280388132528705,6.162,5.057,3.95,3.866,P,True,6.162,3.818,neutral,damaging,uncertain,P,True,3.95,4.058,neutral,damaging,uncertain,neutral,,-0.2638,0.0798,-22.2419,-4.73329170270735,0.6045646846032936,Uncertain,0.7415,pathogenic,-3.929,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215V,NP_000537:p.Ser215Val,,,,,saturation_mutlist,,,,,,,,-0.25947,-0.392845596075058,,-0.70162360903691,,-0.480546804518455,,Neutral,Neutral,,Neutral,0.4754011757375645,,0.4985659557465088,0.20119,,-1.4671124023087303,,-0.6329612011543652,,Neutral,,Neutral,,0.1986751668248481,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,damaging,uncertain,P,True,3.95,4.058,uncertain,damaging,uncertain,neutral,,-0.3286,0.0798,-22.2419,-7.35595670390969,0.8570647858427285,Pathogenic,0.9623,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +S215W,NP_000537:p.Ser215Trp,,,,,saturation_mutlist,,,,,,,,3.80919,-0.11738156557083128,,-0.7814250502094812,,1.5138824748952595,,Uncertain,Neutral,,Neutral,0.5521212541357606,,0.5490255887637362,7.74655,,-1.5266666549886423,,3.1099416725056788,,Uncertain,,Destabilizing,,0.3284293719915392,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,neutral,uncertain,P,True,3.95,4.058,uncertain,neutral,uncertain,neutral,,-0.3609,0.0798,-22.2419,-6.97005118812259,0.869837277193661,Pathogenic,0.9678,pathogenic,-4.558,available,https://doi.org/10.1101/2022.10.22.513328 +S215Y,NP_000537:p.Ser215Tyr,,,,,saturation_mutlist,,,,,,,,2.8977,-0.042068591117858906,,-0.3856479085079219,,1.256026045746039,,Uncertain,Neutral,,Neutral,0.6396231065063036,,0.392099329736591,10.11056,,-1.1794330637771289,,4.465563468111435,,Uncertain,,Destabilizing,,0.5084292689131854,6.162,5.057,3.95,3.866,P,True,6.162,3.818,uncertain,uncertain,uncertain,P,True,3.95,4.058,uncertain,neutral,uncertain,neutral,,-0.356,0.0798,-22.2419,-6.68768948551046,0.6885310238208447,Pathogenic,0.9626,pathogenic,-4.065,available,https://doi.org/10.1101/2022.10.22.513328 +V216A,NP_000537:p.Val216Ala,"hg38,17:g.7674884A>G",,,0.961,"COSMIC,saturation_mutlist",,,,,,,,2.99804,1.7720352935791015,2.52551,2.7237174419456682,2.761775,2.860878720972834,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.3327428620783393,0.17599900586840442,0.1628292398825111,-0.6002,2.62256,1.8830468607254902,1.01118,0.6414234303627451,Uncertain,Neutral,Neutral,Neutral,0.21015015774440896,0.34323014977160354,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,damaging,,-0.3456,0.0589,-22.2419,-4.6325659282855,0.2121431528149867,Benign,0.7484,pathogenic,-3.817,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V216C,NP_000537:p.Val216Cys,,,,,saturation_mutlist,,,,,,,,2.17869,1.219409146308899,,2.548553523041924,,2.363621761520962,,Uncertain,Uncertain,,Uncertain,0.1818998578279371,,0.20720862088043415,-0.20669,,2.50069441327345,,1.147002206636725,,Uncertain,,Neutral,,0.39605705912480654,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,damaging,,-0.3005,0.0589,-7.9541,-3.87135867681977,0.590414489585029,Uncertain,0.9298,pathogenic,-3.996,available,https://doi.org/10.1101/2022.10.22.513328 +V216D,NP_000537:p.Val216Asp,,,,,saturation_mutlist,,,,,,,,4.08256,2.7781243324279785,,4.173616626940778,,4.128088313470389,,Destabilizing,Destabilizing,,Destabilizing,0.24343684051691647,,0.23295679546607728,2.50486,,3.598390327951764,,3.0516251639758822,,Uncertain,,Destabilizing,,0.4769649578425036,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,damaging,,-0.5122,0.0589,-22.2419,-7.86367800860004,0.8631213537277933,Pathogenic,0.9994,pathogenic,-4.671,available,https://doi.org/10.1101/2022.10.22.513328 +V216E,NP_000537:p.Val216Glu,"hg19,17:g.7578202A>T, hg19,17:g.7674884A>T, hg38,17:g.7674884A>T",,,0.982,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376672,Uncertain significance,2,,,,,4.92741,2.7409010124206543,5.2820866666666655,4.181704559467968,5.104748333333333,4.554557279733984,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.283968571687387,0.428553925843126,0.40466251987938845,3.36872,5.740813333333333,3.3037459885913365,4.554766666666667,3.3362329942956683,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.5567609414780778,0.638520712209422,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,uncertain,,-0.4695,0.0589,-22.2419,-7.86367800860004,0.8686101236222001,Pathogenic,0.9979,pathogenic,-4.568,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V216F,NP_000537:p.Val216Phe,,,,,saturation_mutlist,,,,,,,,9.00583,1.6934354305267334,,2.860716661590672,,5.933273330795336,,Uncertain,Uncertain,,Destabilizing,0.33694825555571645,,0.5409858729492899,11.78509,,0.4497069279297217,,6.117398463964861,,Uncertain,,Destabilizing,,0.6398089823052433,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,neutral,,-0.4227,0.0589,-22.2419,-7.86367800860004,0.8311410281596893,Pathogenic,0.9916,pathogenic,-4.143,available,https://doi.org/10.1101/2022.10.22.513328 +V216G,NP_000537:p.Val216Gly,"hg19,17:g.7578202A>C, hg19,17:g.7674884A>C, hg38,17:g.7674884A>C",,,0.980,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376671,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,4.66047,2.7440061569213867,5.0873,4.879865707299381,4.873885,4.77016785364969,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.25777829278814696,0.11691029581121881,0.24364098919959995,0.56874,4.620633333333334,3.8924848530510174,2.594686666666667,2.230612426525509,Uncertain,Uncertain,Uncertain,Uncertain,0.2725256939976282,0.3299254602478011,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,damaging,,-0.4714,0.0589,-22.2419,-7.86367800860004,0.8256892002552828,Pathogenic,0.9564,pathogenic,-4.552,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V216H,NP_000537:p.Val216His,,,,,saturation_mutlist,,,,,,,,8.18385,2.5606642532348634,,3.5752173339541162,,5.879533666977058,,Destabilizing,Destabilizing,,Destabilizing,0.2395509433259146,,0.4959655185619778,12.02081,,1.8752751719903158,,6.948042585995158,,Uncertain,,Destabilizing,,0.669924268925304,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,neutral,,-0.5151,0.0589,-22.2419,-7.86367800860004,0.8696118076235965,Pathogenic,0.9995,pathogenic,-4.55,available,https://doi.org/10.1101/2022.10.22.513328 +V216I,NP_000537:p.Val216Ile,,,,,saturation_mutlist,,,,,,,,0.63855,0.4897407341003418,,0.3668861411940884,,0.5027180705970442,,Neutral,Neutral,,Neutral,0.19659021514210342,,0.10220789460900184,1.55815,,1.3778101252033228,,1.4679800626016615,,Neutral,,Neutral,,1.052845066635871,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,neutral,,-0.2811,0.0589,-22.2419,-3.79034313394866,0.148946011181657,Benign,0.2941,benign,-3.402,available,https://doi.org/10.1101/2022.10.22.513328 +V216K,NP_000537:p.Val216Lys,,,,,saturation_mutlist,,,,,,,,6.65106,2.6363239002227785,,5.613935656278746,,6.132497828139373,,Destabilizing,Destabilizing,,Destabilizing,0.31154124559978097,,0.7982149925568791,6.47545,,3.658668988734025,,5.067059494367013,,Destabilizing,,Destabilizing,,0.7926619636819989,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,neutral,,-0.5084,0.0589,-22.2419,-7.86367800860004,0.8661180589912671,Pathogenic,0.9986,pathogenic,-4.689,available,https://doi.org/10.1101/2022.10.22.513328 +V216L,NP_000537:p.Val216Leu,"hg19,17:g.7578203C>A, hg19,17:g.7578203C>G, hg19,17:g.7674885C>A, hg38,17:g.7674885C>A, hg38,17:g.7674885C>G",,,0.948,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","406596, 376670","Conflicting classifications of pathogenicity, Conflicting classifications of pathogenicity","1, 1",,,,,1.85056,1.283617787361145,2.0436533333333333,1.2069497174477424,1.9471066666666665,1.5287548587238713,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.3457783581640656,0.43880797701145857,0.23393957187528686,2.16377,1.9995433333333335,1.0041864278427508,2.0816566666666665,1.5839782139213754,Uncertain,Uncertain,Uncertain,Neutral,0.9327787086740111,0.9317317389324121,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,neutral,,-0.3462,0.0589,-22.2419,-3.74686827650794,0.1379060289651364,Benign,0.9153,pathogenic,-3.549,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V216M,NP_000537:p.Val216Met,"hg19,17:g.7578203C>T, hg19,17:g.7674885C>T, hg38,17:g.7674885C>T",,,0.956,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182965,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,2.59088,1.732017207145691,5.173583333333333,2.160638861766847,3.8822316666666667,2.3757594308834236,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.2874997800024515,2.7678281233888464,0.41958794431233715,1.44597,2.7030600000000002,1.4191278936383753,2.074515,1.4325489468191877,Uncertain,Neutral,Uncertain,Neutral,1.4659072082729747,0.7252865430794304,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,neutral,,-0.3553,0.0589,-22.2419,-4.72138030490248,0.8674075800808352,Pathogenic,0.9421,pathogenic,-4.043,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V216N,NP_000537:p.Val216Asn,,,,,saturation_mutlist,,,,,,,,3.36931,2.8077208614349365,,2.8053870581440687,,3.0873485290720346,,Uncertain,Destabilizing,,Destabilizing,0.2378351828848678,,0.23076926242906062,1.98546,,2.417236476704481,,2.2013482383522405,,Uncertain,,Uncertain,,0.38718106280234726,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,damaging,,-0.5,0.0589,-22.2419,-7.86367800860004,0.8674033412184625,Pathogenic,0.9972,pathogenic,-4.521,available,https://doi.org/10.1101/2022.10.22.513328 +V216P,NP_000537:p.Val216Pro,,,,,saturation_mutlist,,,,,,,,3.37633,2.2685218715667723,,5.985755010359981,,4.68104250517999,,Destabilizing,Destabilizing,,Destabilizing,0.3195369735451306,,0.6352324269862065,2.06447,,6.819053097755322,,4.441761548877661,,Uncertain,,Destabilizing,,0.8470478927690943,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,damaging,,-0.5499,0.0589,-22.2419,-7.86367800860004,0.8565058783001898,Pathogenic,0.998,pathogenic,-4.524,available,https://doi.org/10.1101/2022.10.22.513328 +V216Q,NP_000537:p.Val216Gln,,,,,saturation_mutlist,,,,,,,,4.43486,2.6055725955963136,,3.210971555435346,,3.8229157777176725,,Destabilizing,Destabilizing,,Destabilizing,0.26034329706606346,,0.465831173763622,3.393,,2.500642369118585,,2.946821184559292,,Uncertain,,Uncertain,,0.6733599676831011,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,uncertain,,-0.4801,0.0589,-22.2419,-7.86367800860004,0.8700875517357861,Pathogenic,0.9967,pathogenic,-4.502,available,https://doi.org/10.1101/2022.10.22.513328 +V216R,NP_000537:p.Val216Arg,"hg19,17:g.7578202_7578203delinsCT",,,,"cBioPortal,saturation_mutlist",,,,,,,,9.48094,2.659154052734375,,4.74849407224976,,7.11471703612488,,Destabilizing,Destabilizing,,Destabilizing,0.2570687901593367,,0.7970449679744384,9.49715,,2.48079657738426,,5.988973288692129,,Uncertain,,Destabilizing,,0.7417642901661439,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,neutral,,-0.5294,0.0589,-22.2419,-7.86367800860004,0.8707826014486361,Pathogenic,0.9956,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328 +V216S,NP_000537:p.Val216Ser,,,,,saturation_mutlist,,,,,,,,3.57824,2.351358995437622,,3.499549090155378,,3.5388945450776887,,Destabilizing,Destabilizing,,Destabilizing,0.25202331833858294,,0.21639405468368747,-0.20193,,2.963307135607256,,1.380688567803628,,Uncertain,,Neutral,,0.22019893520640235,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,damaging,,-0.3814,0.0589,-8.9541,-6.40680338440801,0.8668588301280018,Pathogenic,0.96,pathogenic,-4.256,available,https://doi.org/10.1101/2022.10.22.513328 +V216T,NP_000537:p.Val216Thr,,,,,saturation_mutlist,,,,,,,,1.89817,1.5642538690567016,,2.2128867751792587,,2.0555283875896295,,Uncertain,Uncertain,,Uncertain,0.30764988359602863,,0.17875869207519546,0.11124,,2.2802803609031965,,1.1957601804515983,,Uncertain,,Neutral,,0.5189967665748452,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,damaging,,-0.3646,0.0589,-22.2419,-4.64532572970529,0.7461695455299772,Pathogenic,0.882,pathogenic,-3.96,available,https://doi.org/10.1101/2022.10.22.513328 +V216W,NP_000537:p.Val216Trp,,,,,saturation_mutlist,,,,,,,,15.17184,2.1176999616622925,7.02823,4.531689948975231,11.100035,9.851764974487615,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.27249970953476116,1.7820608968270417,0.7914656746186312,20.33332,11.063833333333333,0.8766259294339411,15.698576666666668,10.604972964716971,Destabilizing,Uncertain,Destabilizing,Destabilizing,8.48735208220771,0.8557833462248513,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,neutral,,-0.4633,0.0589,-22.2419,-7.86367800860004,0.8398159294110228,Pathogenic,0.9998,pathogenic,-4.602,available,https://doi.org/10.1101/2022.10.22.513328 +V216Y,NP_000537:p.Val216Tyr,,,,,saturation_mutlist,,,,,,,,11.91053,2.040942506790161,,4.072044193215613,,7.991287096607806,,Destabilizing,Destabilizing,,Destabilizing,0.3096166501768907,,0.6370504193245553,14.62326,,0.8964644166804661,,7.759862208340233,,Uncertain,,Destabilizing,,0.7846417161067352,0.955,0.916,1.2,1.079,,True,0.955,,neutral,neutral,neutral,,True,1.2,,neutral,neutral,neutral,neutral,,-0.4662,0.0589,-22.2419,-7.86367800860004,0.8661691621949326,Pathogenic,0.9993,pathogenic,-4.473,available,https://doi.org/10.1101/2022.10.22.513328 +V217A,NP_000537:p.Val217Ala,"hg19,17:g.7578199A>G, hg38,17:g.7674881A>G",,,0.647,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.36805,1.7631588697433471,1.8348066666666665,1.5573609116219798,2.1014283333333332,1.96270545581099,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.2326634187145309,0.24058372296470007,0.3438809204599008,0.99554,1.5189333333333332,1.0073478046662896,1.2572366666666666,1.0014439023331447,Neutral,Neutral,Neutral,Neutral,0.4999530999559415,0.20898157239266743,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,neutral,,-0.0771,2.1286,-6.9571,-2.14745108374035,5.431745333075285e-06,Benign,0.3266,benign,-3.348,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V217C,NP_000537:p.Val217Cys,,,,,saturation_mutlist,,,,,,,,1.9507,0.9140725660324097,,1.8366107282023265,,1.8936553641011633,,Neutral,Neutral,,Neutral,0.18020605147580984,,0.2955149833094531,0.98968,,1.5711654432506752,,1.2804227216253377,,Neutral,,Neutral,,0.17681184998214156,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,neutral,,-0.102,2.1286,-6.3721,-2.22935959270386,3.167327535270623e-05,Benign,0.8129,pathogenic,-3.524,available,https://doi.org/10.1101/2022.10.22.513328 +V217D,NP_000537:p.Val217Asp,,,,,saturation_mutlist,,,,,,,,2.95353,2.17974645614624,,2.1934800015582105,,2.5735050007791056,,Uncertain,Destabilizing,,Uncertain,0.3668440049795349,,0.2955327434130872,2.58194,,1.3972004526733794,,1.9895702263366897,,Uncertain,,Neutral,,0.35157063013757867,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,neutral,,-0.2539,2.1286,-8.957,-4.97791765137677,0.0549242798352804,Benign,0.9656,pathogenic,-4.013,available,https://doi.org/10.1101/2022.10.22.513328 +V217E,NP_000537:p.Val217Glu,"hg19,17:g.7578199A>T, hg38,17:g.7674881A>T",,,0.723,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.54412,1.7536848998069763,2.636506666666667,1.6072156003971587,2.5903133333333335,2.0756678001985795,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.3373126182118971,0.2927706629580375,0.3008079473032399,1.75016,1.81372,1.0125109729570227,1.78194,1.3813354864785112,Neutral,Neutral,Neutral,Neutral,0.43844234467031123,0.34427380922966516,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,uncertain,,-0.279,2.1286,-22.2448,-4.97791765137677,0.4003982983912539,Uncertain,0.8706,pathogenic,-4.08,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V217F,NP_000537:p.Val217Phe,,,,,saturation_mutlist,,,,,,,,5.29202,0.8041231083869934,,0.3464796866080091,,2.8192498433040045,,Uncertain,Neutral,,Uncertain,0.2321170660770043,,0.14191162246236871,4.63039,,0.025448200422109796,,2.327919100211055,,Uncertain,,Uncertain,,0.14361462251890372,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,uncertain,,-0.1543,2.1286,-6.9571,-2.17564102055245,0.0372337065038907,Benign,0.597,pathogenic,-3.591,available,https://doi.org/10.1101/2022.10.22.513328 +V217G,NP_000537:p.Val217Gly,"hg19,17:g.7578198_7578199delinsAC, hg19,17:g.7578199A>C, hg19,17:g.7674881A>C, hg38,17:g.7674881A>C",,,0.731,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,3.72478,2.693210496902466,4.1337866666666665,3.0493323834432715,3.9292833333333332,3.3870561917216357,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.2485452766654044,0.29362014875610204,0.5378320064598356,2.21823,3.4504533333333334,2.3372053261429557,2.834341666666667,2.2777176630714777,Uncertain,Uncertain,Uncertain,Uncertain,0.5973790380394085,0.2530253469400173,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,neutral,,-0.208,2.1286,-7.957,-3.08625379543033,0.0023281309902917,Benign,0.7,pathogenic,-3.831,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V217H,NP_000537:p.Val217His,,,,,saturation_mutlist,,,,,,,,4.78584,1.6143052864074707,,1.1633432983597365,,2.9745916491798683,,Uncertain,Uncertain,,Uncertain,0.30477084155080736,,0.30560970275530586,3.72371,,0.6565581419136312,,2.1901340709568156,,Uncertain,,Uncertain,,0.25793059290903814,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,uncertain,,-0.3247,2.1286,-22.2448,-3.9406222399082,0.2321525260214935,Benign,0.9525,pathogenic,-4.13,available,https://doi.org/10.1101/2022.10.22.513328 +V217I,NP_000537:p.Val217Ile,,,,,saturation_mutlist,,,,,,,,0.0881,-0.02722904682159423,0.02585333333333335,-0.284370956227419,0.056976666666666675,-0.09813547811370948,Neutral,Neutral,Neutral,Neutral,Neutral,0.15071986668265688,0.23500304967288307,0.19281251492158813,-0.35996,0.31939,-0.17291839931291517,-0.020284999999999997,-0.26643919965645757,Neutral,Neutral,Neutral,Neutral,0.21151410922205638,0.07792124565902135,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,uncertain,,-0.0097,2.1286,-6.3721,-1.43408541530922,3.291268268078736e-06,Benign,0.1097,benign,-3.194,available,https://doi.org/10.1101/2022.10.22.513328 +V217K,NP_000537:p.Val217Lys,,,,,saturation_mutlist,,,,,,,,1.99907,1.9729712677001954,,1.5828562604267102,,1.790963130213355,,Neutral,Uncertain,,Neutral,0.30636445108437327,,0.37939210634512804,0.98389,,0.9061163878813635,,0.9450031939406818,,Neutral,,Neutral,,0.19333887333710864,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,uncertain,,-0.318,2.1286,-22.2448,-3.71481439691539,0.0131949051782018,Benign,0.9374,pathogenic,-3.907,available,https://doi.org/10.1101/2022.10.22.513328 +V217L,NP_000537:p.Val217Leu,"hg19,17:g.7578200C>A, hg19,17:g.7578200C>G, hg38,17:g.7674882C>A",,,0.544,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1386154,Conflicting classifications of pathogenicity,1,,,,,0.28818,0.9541908812522888,0.5619033333333333,-0.14689457857487728,0.42504166666666665,0.07064271071256135,Neutral,Neutral,Neutral,Neutral,Neutral,0.20847353112187939,0.2647278215240871,0.02882429177288636,-0.28135,0.28481,-0.11686926952152195,0.0017300000000000093,-0.19910963476076096,Neutral,Neutral,Neutral,Neutral,0.7169313169799927,0.09784139182797379,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,uncertain,,-0.0482,2.1286,-1.1627,-0.539631388372405,7.646786506834938e-07,Benign,0.3919,ambiguous,-3.071,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V217M,NP_000537:p.Val217Met,"hg19,17:g.7578200C>T, hg38,17:g.7674882C>T",,3.9769970491e-06,0.451,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",183071,Conflicting classifications of pathogenicity,1,,,,,0.2395,1.2211550760269165,1.31145,0.5197346311117342,0.775475,0.3796173155558671,Neutral,Neutral,Uncertain,Neutral,Neutral,0.2208519033633646,0.16055783838438623,0.04848634129377874,-0.27087,0.6921766666666667,0.49579864262992085,0.21065333333333333,0.11246432131496042,Neutral,Neutral,Neutral,Neutral,0.5667650980393514,0.18791112514288125,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,uncertain,,-0.0682,2.1286,-3.3132,-1.40428730991163,0.0003601299173597,Benign,0.3012,benign,-3.274,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V217N,NP_000537:p.Val217Asn,,,,,saturation_mutlist,,,,,,,,2.60457,2.140167112350464,,1.7155876388811795,,2.1600788194405895,,Uncertain,Destabilizing,,Uncertain,0.3260765480700525,,0.2235845535164057,2.06594,,1.1888497912284641,,1.627394895614232,,Uncertain,,Neutral,,0.25513734307192626,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,neutral,,-0.3096,2.1286,-22.2448,-4.88421572979935,0.0777185368210788,Benign,0.9073,pathogenic,-3.906,available,https://doi.org/10.1101/2022.10.22.513328 +V217P,NP_000537:p.Val217Pro,,,,,saturation_mutlist,,,,,,,,5.44193,3.1380138397216797,,4.2796576503478,,4.8607938251739,,Destabilizing,Destabilizing,,Destabilizing,0.2764750431811626,,0.44589300015853556,4.18365,,3.388285421269049,,3.785967710634525,,Destabilizing,,Destabilizing,,0.6389205177712607,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,neutral,,-0.3595,2.1286,-22.2448,-5.33840963704239,0.3005360150511274,Benign,0.9959,pathogenic,-4.132,available,https://doi.org/10.1101/2022.10.22.513328 +V217Q,NP_000537:p.Val217Gln,,,,,saturation_mutlist,,,,,,,,2.00186,1.748870816230774,,1.411646072244434,,1.7067530361222172,,Uncertain,Uncertain,,Neutral,0.3230303652264548,,0.22826048574867364,1.08754,,1.0454779547248425,,1.0665089773624212,,Neutral,,Neutral,,0.21970933419887004,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,uncertain,,-0.2897,2.1286,-22.2448,-4.97791765137677,0.1720459207965658,Benign,0.8476,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328 +V217R,NP_000537:p.Val217Arg,,,,,saturation_mutlist,,,,,,,,2.47289,1.9182132482528687,,1.0209642381474968,,1.7469271190737485,,Uncertain,Uncertain,,Neutral,0.31219829285608103,,0.3476231213919774,1.38119,,0.5033335639127111,,0.9422617819563555,,Neutral,,Neutral,,0.17113342338209053,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,uncertain,,-0.2712,2.1286,-8.957,-3.10712675617726,0.0030653230066194,Benign,0.8821,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328 +V217S,NP_000537:p.Val217Ser,,,,,saturation_mutlist,,,,,,,,3.34559,1.8362515592575073,,2.146550428945793,,2.746070214472897,,Uncertain,Uncertain,,Uncertain,0.2962871729353166,,0.40877359152599235,1.72681,,1.4075084520192949,,1.5671592260096474,,Neutral,,Neutral,,0.3355946951112581,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,neutral,,-0.1829,2.1286,-7.3721,-1.45163155614739,4.887914890137701e-05,Benign,0.5319,ambiguous,-3.431,available,https://doi.org/10.1101/2022.10.22.513328 +V217T,NP_000537:p.Val217Thr,,,,,saturation_mutlist,,,,,,,,2.02982,1.2009441065788269,,1.3226240667368827,,1.6762220333684414,,Uncertain,Uncertain,,Neutral,0.27233089345311695,,0.18913785353573004,0.90221,,0.9161899502025891,,0.9091999751012945,,Neutral,,Neutral,,0.2412607262664315,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,neutral,,-0.0771,2.1286,-3.2292,-2.04752250805652,4.929221949433084e-07,Benign,0.2832,benign,-3.189,available,https://doi.org/10.1101/2022.10.22.513328 +V217W,NP_000537:p.Val217Trp,,,,,saturation_mutlist,,,,,,,,5.52004,0.8188048315048218,,0.11211003363430577,,2.8160750168171527,,Uncertain,Neutral,,Uncertain,0.2305912053453589,,0.20692227274362868,4.93303,,-0.1753239560858011,,2.378853021957099,,Uncertain,,Uncertain,,0.22766398384585151,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,uncertain,,-0.205,2.1286,-8.957,-2.55738323022044,0.0368353917147424,Benign,0.9613,pathogenic,-4.116,available,https://doi.org/10.1101/2022.10.22.513328 +V217Y,NP_000537:p.Val217Tyr,,,,,saturation_mutlist,,,,,,,,5.63089,0.7613348627090454,,0.6017419739661266,,3.1163159869830634,,Uncertain,Neutral,,Destabilizing,0.2409147092892884,,0.24474562710435943,5.63426,,0.18128814523897177,,2.907774072619486,,Uncertain,,Uncertain,,0.16184498692432445,8.103,5.981,7.505,5.574,,True,8.103,,neutral,neutral,neutral,,True,7.505,,neutral,neutral,neutral,uncertain,,-0.2079,2.1286,-8.957,-2.29664129861387,0.0150135026458018,Benign,0.9199,pathogenic,-3.854,available,https://doi.org/10.1101/2022.10.22.513328 +V218A,NP_000537:p.Val218Ala,"hg38,17:g.7674878A>G",,,0.974,"COSMIC,saturation_mutlist",,,,,,,,2.71262,1.7310489702224732,3.0442199999999997,1.74276366001451,2.8784199999999998,2.227691830007255,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.23007540134254903,0.5228693133725353,0.04032712552944285,-0.75846,1.1310666666666667,1.9525967132931716,0.18630333333333332,0.5970683566465858,Neutral,Neutral,Neutral,Neutral,0.8224563366863651,0.12586514945931965,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,damaging,,-0.3301,0.227,-22.2448,-4.07629893885742,0.2312405653619732,Benign,0.8565,pathogenic,-3.778,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V218C,NP_000537:p.Val218Cys,,,,,saturation_mutlist,,,,,,,,1.90222,0.8331215620040894,,1.8409312556985995,,1.8715756278492997,,Neutral,Neutral,,Neutral,0.25344794662330555,,0.10732434369206724,-0.52385,,2.14315863619617,,0.8096543180980851,,Uncertain,,Neutral,,0.06539989987880948,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,damaging,,-0.2902,0.227,-8.957,-5.55160402836846,0.6470775282990314,Uncertain,0.94,pathogenic,-4.092,available,https://doi.org/10.1101/2022.10.22.513328 +V218D,NP_000537:p.Val218Asp,,,,,saturation_mutlist,,,,,,,,3.47117,2.639559335708618,,2.748337258424596,,3.109753629212298,,Uncertain,Destabilizing,,Destabilizing,0.31262664454361083,,0.12969929625568188,2.32706,,3.4283394022594424,,2.877699701129721,,Uncertain,,Uncertain,,0.009772964445926029,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,damaging,,-0.4967,0.227,-22.2448,-6.84820493328757,0.8208157450786532,Pathogenic,0.9978,pathogenic,-4.612,available,https://doi.org/10.1101/2022.10.22.513328 +V218E,NP_000537:p.Val218Glu,"hg19,17:g.7578196A>T, hg19,17:g.7674878A>T, hg38,17:g.7674878A>T",,,0.977,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1754112,Likely pathogenic,2,Likely oncogenic,1,,,2.41611,2.3005012702941894,3.5173466666666666,2.2657287460267237,2.966728333333333,2.340919373013362,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,0.35521527025690586,0.4736200114953852,0.21004025661113246,2.82207,4.5,2.979420909153577,3.661035,2.9007454545767883,Uncertain,Uncertain,Destabilizing,Uncertain,1.180933703388975,0.1622724574695964,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,uncertain,,-0.454,0.227,-22.2448,-6.84820493328757,0.8427049062844838,Pathogenic,0.99,pathogenic,-4.549,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V218F,NP_000537:p.Val218Phe,,,,,saturation_mutlist,,,,,,,,1.93522,0.9352475070953369,,1.098020883323501,,1.5166204416617504,,Neutral,Neutral,,Neutral,0.5306205689618749,,0.4452098623290953,9.87153,,0.544386138771536,,5.207958069385768,,Uncertain,,Destabilizing,,0.47329321939187674,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,neutral,,-0.4073,0.227,-22.2448,-5.14926000963313,0.2814432000834319,Benign,0.8712,pathogenic,-3.984,available,https://doi.org/10.1101/2022.10.22.513328 +V218G,NP_000537:p.Val218Gly,"hg19,17:g.7578196A>C, hg19,17:g.7674878A>C, hg38,17:g.7674878A>C",,,0.972,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528249,Conflicting classifications of pathogenicity,1,,,,,4.32915,2.6098919486999512,5.015643333333333,3.5436712438384927,4.672396666666667,3.9364106219192463,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.20845674055245422,1.0287678011528592,0.14620361493524853,0.38252,6.231743333333333,3.8717989323199915,3.307131666666667,2.1271594661599957,Uncertain,Uncertain,Destabilizing,Uncertain,1.4708162458610827,0.18662563927378015,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,damaging,,-0.4559,0.227,-22.2448,-6.84820493328757,0.4708204641576821,Uncertain,0.9144,pathogenic,-4.352,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V218H,NP_000537:p.Val218His,,,,,saturation_mutlist,,,,,,,,3.60981,2.1405353927612305,,1.7673072747878409,,2.6885586373939203,,Uncertain,Destabilizing,,Uncertain,0.3766523606796919,,0.36298735178643077,9.74484,,1.6581956714592934,,5.701517835729646,,Uncertain,,Destabilizing,,0.3717247526685355,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,neutral,,-0.4997,0.227,-22.2448,-5.99807811825051,0.8154172166641043,Pathogenic,0.9962,pathogenic,-4.57,available,https://doi.org/10.1101/2022.10.22.513328 +V218I,NP_000537:p.Val218Ile,,,,,saturation_mutlist,,,,,,,,-1.13003,0.014936628341674796,,-0.07162193055085567,,-0.6008259652754279,,Neutral,Neutral,,Neutral,0.18925230682285288,,0.18980319143968585,0.34791,,0.488486368717471,,0.41819818435873546,,Neutral,,Neutral,,0.23034365652487224,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,neutral,,-0.1927,0.227,-7.957,-1.01884231858046,0.0012174353382078,Benign,0.1778,benign,-3.271,available,https://doi.org/10.1101/2022.10.22.513328 +V218K,NP_000537:p.Val218Lys,,,,,saturation_mutlist,,,,,,,,1.84952,2.4866692543029787,,2.593527370218046,,2.221523685109023,,Uncertain,Destabilizing,,Uncertain,0.25778768844924976,,0.14001351864368983,3.40681,,3.392609817810534,,3.399709908905267,,Destabilizing,,Destabilizing,,0.0348899886610478,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,neutral,,-0.493,0.227,-22.2448,-6.84820493328757,0.8122807930460171,Pathogenic,0.9941,pathogenic,-4.634,available,https://doi.org/10.1101/2022.10.22.513328 +V218L,NP_000537:p.Val218Leu,"hg19,17:g.7578197C>A, hg19,17:g.7674879C>A, hg38,17:g.7674879C>A",,,0.864,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.39018,0.581010775566101,1.9853766666666666,0.2678742988101498,0.7975983333333333,-0.06115285059492512,Neutral,Neutral,Neutral,Neutral,Neutral,0.43297194382546766,0.2722082291596311,0.35935409769088444,0.10217,0.7671199999999999,0.39550524466226644,0.43464499999999995,0.2488376223311332,Neutral,Neutral,Neutral,Neutral,2.298368746843436,0.3339973146866737,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,neutral,,-0.2468,0.227,-5.7872,-2.07009444312409,0.0001224813597769,Benign,0.7135,pathogenic,-3.347,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V218M,NP_000537:p.Val218Met,"hg19,17:g.7578197C>T, hg19,17:g.7578197_7578198delinsTT, hg19,17:g.7674879_7674880delinsTT, hg38,17:g.7674879C>T, hg38,17:g.7674879_7674880delinsTT",,,0.873,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",237952,Conflicting classifications of pathogenicity,1,,,,,-0.53418,0.933609447479248,2.24637,0.9488141713990528,0.856095,0.2073170856995264,Uncertain,Neutral,Neutral,Neutral,Neutral,0.4154958130069377,0.4848258112628357,0.3504426619023427,-0.15397,0.9689333333333333,0.7900171467733678,0.40748166666666663,0.31802357338668386,Neutral,Neutral,Neutral,Neutral,0.43423057671651305,0.376862384572173,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,neutral,,-0.3398,0.227,-22.2448,-3.15165734968342,0.0683214397083793,Benign,0.7748,pathogenic,-3.768,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V218N,NP_000537:p.Val218Asn,,,,,saturation_mutlist,,,,,,,,2.48062,2.5288322734832764,,1.9225907406252285,,2.201605370312614,,Uncertain,Destabilizing,,Uncertain,0.29605418972714026,,0.01978197004208489,1.02042,,2.0925663103725243,,1.5564931551862622,,Uncertain,,Neutral,,0.12468880455055137,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,damaging,,-0.4846,0.227,-22.2448,-6.84820493328757,0.8213553149591172,Pathogenic,0.9918,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +V218P,NP_000537:p.Val218Pro,,,,,saturation_mutlist,,,,,,,,3.54123,2.640414037704468,,5.745527507620356,,4.643378753810178,,Destabilizing,Destabilizing,,Destabilizing,0.22846049553067582,,0.5899862246097294,2.85703,,5.900363785280984,,4.378696892640492,,Uncertain,,Destabilizing,,1.3717845722559816,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,damaging,,-0.5344,0.227,-22.2448,-6.84820493328757,0.8275669389609562,Pathogenic,0.9965,pathogenic,-4.465,available,https://doi.org/10.1101/2022.10.22.513328 +V218Q,NP_000537:p.Val218Gln,,,,,saturation_mutlist,,,,,,,,1.90536,2.2530043363571166,,1.7895773250057794,,1.8474686625028895,,Neutral,Destabilizing,,Neutral,0.309187221248775,,0.17869928116005548,1.96581,,2.024087229647261,,1.9949486148236306,,Uncertain,,Neutral,,0.34070879211632615,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,uncertain,,-0.4646,0.227,-22.2448,-6.84820493328757,0.6884592284117206,Pathogenic,0.9843,pathogenic,-4.516,available,https://doi.org/10.1101/2022.10.22.513328 +V218R,NP_000537:p.Val218Arg,,,,,saturation_mutlist,,,,,,,,2.62691,2.417369785308838,,1.8155936099821075,,2.221251804991054,,Uncertain,Destabilizing,,Uncertain,0.24644890839581662,,0.14282656741014324,6.73936,,2.3058816379127887,,4.522620818956394,,Uncertain,,Destabilizing,,0.138443972047512,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,neutral,,-0.514,0.227,-22.2448,-6.84820493328757,0.8462167925899768,Pathogenic,0.9872,pathogenic,-4.577,available,https://doi.org/10.1101/2022.10.22.513328 +V218S,NP_000537:p.Val218Ser,,,,,saturation_mutlist,,,,,,,,3.4033,2.1140486812591552,,2.4948605037782787,,2.9490802518891392,,Uncertain,Destabilizing,,Uncertain,0.2598570907184572,,0.22202076656867922,0.03862,,3.020096646182529,,1.5293583230912644,,Uncertain,,Neutral,,0.22875311225343273,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,damaging,,-0.4338,0.227,-22.2448,-4.82234701020296,0.2872875302666632,Benign,0.9448,pathogenic,-4.08,available,https://doi.org/10.1101/2022.10.22.513328 +V218T,NP_000537:p.Val218Thr,,,,,saturation_mutlist,,,,,,,,2.14126,1.437900881767273,,1.4441679604297375,,1.7927139802148688,,Uncertain,Uncertain,,Neutral,0.19241411636424663,,0.06044153724210335,0.83647,,2.0057213854541343,,1.421095692727067,,Uncertain,,Neutral,,0.23687534131587215,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,damaging,,-0.3491,0.227,-22.2448,-4.02487502035216,0.0193278380673465,Benign,0.8347,pathogenic,-3.717,available,https://doi.org/10.1101/2022.10.22.513328 +V218W,NP_000537:p.Val218Trp,"hg19,17:g.7578196_7578197delinsCA",,,,"cBioPortal,saturation_mutlist",,,,,,,,2.42425,1.2532658934593202,,1.2745076456839801,,1.8493788228419898,,Uncertain,Uncertain,,Neutral,0.5958669547358421,,0.42298126975861716,17.15761,,1.1662982575944134,,9.161954128797205,,Uncertain,,Destabilizing,,0.5314594725033401,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,neutral,,-0.4478,0.227,-22.2448,-5.99807811825051,0.786403056085973,Pathogenic,0.9974,pathogenic,-4.656,available,https://doi.org/10.1101/2022.10.22.513328 +V218Y,NP_000537:p.Val218Tyr,,,,,saturation_mutlist,,,,,,,,2.61093,1.2718210315704346,,1.6100127496084673,,2.110471374804234,,Uncertain,Uncertain,,Uncertain,0.5888352551284779,,0.36597507798158985,13.65715,,1.2765769383677148,,7.466863469183857,,Uncertain,,Destabilizing,,0.5242621311197097,3.135,2.463,2.195,1.509,,False,3.135,,neutral,neutral,neutral,,False,2.195,,neutral,neutral,neutral,neutral,,-0.3778,0.227,-7.957,-3.68767768601299,0.0502276369279152,Benign,0.9912,pathogenic,-4.084,available,https://doi.org/10.1101/2022.10.22.513328 +P219A,NP_000537:p.Pro219Ala,"hg19,17:g.7578194G>C, hg38,17:g.7674876G>C",,,0.937,"cBioPortal,ClinVar,saturation_mutlist",2850523,Uncertain significance,1,,,,,2.01482,0.8324086570739746,,0.13149954690237364,,1.0731597734511866,,Uncertain,Neutral,,Neutral,0.4554634408552685,,0.23662673409065887,2.61301,,-0.1446885047355504,,1.2341607476322247,,Uncertain,,Neutral,,0.07019778931154404,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,uncertain,,-0.3174,0.1119,-22.2448,-5.98951135681437,0.0433620437223079,Benign,0.3597,ambiguous,-3.882,available,https://doi.org/10.1101/2022.10.22.513328 +P219C,NP_000537:p.Pro219Cys,"hg38,17:g.7674875_7674876delinsCA",,,,"COSMIC,saturation_mutlist",,,,,,,,2.18584,0.2967536997795105,2.0007933333333336,0.8600105342054399,2.0933166666666665,1.5229252671027198,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.3661548571101056,0.08815114910702466,0.0440708871910531,3.17864,1.3428566666666668,0.6019814903588694,2.2607483333333334,1.8903107451794348,Uncertain,Uncertain,Uncertain,Neutral,1.1520183597302411,0.08276855478435036,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,uncertain,,-0.3501,0.1119,-22.2448,-6.95438318069062,0.8131674984941484,Pathogenic,0.8789,pathogenic,-4.453,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P219D,NP_000537:p.Pro219Asp,,,,,saturation_mutlist,,,,,,,,2.9288,1.0319395953416823,,0.23842844997553456,,1.5836142249877672,,Uncertain,Uncertain,,Neutral,0.5197675784540845,,0.24978387785534448,3.38788,,-0.09719945673821508,,1.6453402716308925,,Uncertain,,Neutral,,0.16825873620952522,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,uncertain,,-0.3082,0.1119,-8.957,-4.07040711956028,0.1107043264782746,Benign,0.8527,pathogenic,-4.096,available,https://doi.org/10.1101/2022.10.22.513328 +P219E,NP_000537:p.Pro219Glu,,,,,saturation_mutlist,,,,,,,,2.23066,0.8134846699237823,,0.05123937487258814,,1.140949687436294,,Uncertain,Neutral,,Neutral,0.5394993264766782,,0.26401488699973835,3.02228,,-0.2688423469421917,,1.376718826528904,,Uncertain,,Neutral,,0.2012271652767418,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,neutral,,-0.3598,0.1119,-22.2448,-5.74473666335954,0.2219269852982077,Benign,0.7876,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +P219F,NP_000537:p.Pro219Phe,,,,,saturation_mutlist,,,,,,,,1.56236,0.4388470411300659,,-0.6686767345945305,,0.44684163270273475,,Neutral,Neutral,,Neutral,0.527834635945688,,0.04102061893753162,2.87826,,-0.7467045422938233,,1.0657777288530883,,Uncertain,,Neutral,,0.2670686303022348,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,neutral,,-0.3785,0.1119,-22.2448,-7.82669451732048,0.4780335939451759,Uncertain,0.9443,pathogenic,-4.548,available,https://doi.org/10.1101/2022.10.22.513328 +P219G,NP_000537:p.Pro219Gly,,,,,saturation_mutlist,,,,,,,,2.43706,1.1326834845542908,,1.079120213561968,,1.7580901067809838,,Uncertain,Uncertain,,Neutral,0.35351840106862925,,0.21356281081287334,2.38209,,0.8618442220744821,,1.621967111037241,,Uncertain,,Neutral,,0.069797091858577,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,uncertain,,-0.3318,0.1119,-22.2448,-7.82669451732048,0.7649985781762616,Pathogenic,0.7935,pathogenic,-4.307,available,https://doi.org/10.1101/2022.10.22.513328 +P219H,NP_000537:p.Pro219His,"hg19,17:g.7578193G>T, hg38,17:g.7674875G>T",,,0.957,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.60157,0.6863701128959656,0.9083900000000001,-0.3645025384200793,1.7549800000000002,1.1185337307899603,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.5114034894509054,0.3984437348819362,0.15592000227658415,3.53538,0.0791366666666667,-0.6022930631800824,1.8072583333333334,1.4665434684099588,Uncertain,Uncertain,Neutral,Neutral,1.0980140006494554,0.16359848001546784,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,neutral,,-0.3561,0.1119,-22.2448,-7.82669451732048,0.8292994102900393,Pathogenic,0.7211,pathogenic,-4.339,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P219I,NP_000537:p.Pro219Ile,,,,,saturation_mutlist,,,,,,,,1.81566,0.5460729336738587,,-0.5606205259497951,,0.6275197370251024,,Neutral,Neutral,,Neutral,0.4673571568127825,,0.08773414625230301,3.23096,,-0.5055933401519397,,1.3626833299240302,,Uncertain,,Neutral,,0.3197992608235129,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,neutral,,-0.3616,0.1119,-22.2448,-6.41984487557022,0.714270966358717,Pathogenic,0.9078,pathogenic,-4.488,available,https://doi.org/10.1101/2022.10.22.513328 +P219K,NP_000537:p.Pro219Lys,,,,,saturation_mutlist,,,,,,,,1.91226,0.8165870237350464,,0.1104942075857146,,1.0113771037928574,,Neutral,Neutral,,Neutral,0.4178620583938822,,0.1876122710645364,2.70224,,-0.08262612595240763,,1.3098069370237964,,Uncertain,,Neutral,,0.07133242745233442,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,neutral,,-0.3515,0.1119,-22.2448,-7.82669451732048,0.8322385477189075,Pathogenic,0.8947,pathogenic,-4.404,available,https://doi.org/10.1101/2022.10.22.513328 +P219L,NP_000537:p.Pro219Leu,"hg19,17:g.7578193G>A, hg38,17:g.7674874_7674875delinsAA, hg38,17:g.7674875G>A",,3.9777563863e-06,0.947,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",826488,Uncertain significance,2,,,,,1.50478,0.4470133137702942,0.8649666666666667,-0.7775940833750715,1.1848733333333334,0.36359295831246424,Neutral,Neutral,Neutral,Neutral,Neutral,0.4604664716119128,0.32261359387904837,0.10775709547851925,2.4422,-0.15850333333333333,-0.768404814711635,1.1418483333333334,0.8368975926441826,Uncertain,Uncertain,Neutral,Neutral,0.5673691293642574,0.26964067112615503,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,neutral,,-0.2903,0.1119,-7.3721,-4.32516605469899,0.0014420978298074,Benign,0.4909,ambiguous,-3.799,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P219M,NP_000537:p.Pro219Met,,,,,saturation_mutlist,,,,,,,,1.28497,0.6024990463256836,,-0.18913353605635855,,0.5479182319718207,,Neutral,Neutral,,Neutral,0.453778917325892,,0.09306483308126064,2.39742,,-0.4496755329649195,,0.9738722335175402,,Uncertain,,Neutral,,0.18360786441622812,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,neutral,,-0.3171,0.1119,-22.2448,-5.08192340945849,0.4135269531978684,Uncertain,0.8683,pathogenic,-4.213,available,https://doi.org/10.1101/2022.10.22.513328 +P219N,NP_000537:p.Pro219Asn,,,,,saturation_mutlist,,,,,,,,2.51353,0.9334803593158721,,0.22080110440912792,,1.3671655522045638,,Uncertain,Neutral,,Neutral,0.4413492947224378,,0.22879185909087807,3.37762,,-0.05912285135025006,,1.6592485743248748,,Uncertain,,Neutral,,0.05316216689543981,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,uncertain,,-0.3441,0.1119,-22.2448,-6.71122325445307,0.8285104573792726,Pathogenic,0.8278,pathogenic,-4.304,available,https://doi.org/10.1101/2022.10.22.513328 +P219Q,NP_000537:p.Pro219Gln,,,,,saturation_mutlist,,,,,,,,2.12854,0.8989301109313965,,0.22510569592241883,,1.1768228479612095,,Uncertain,Neutral,,Neutral,0.5062378929543263,,0.15962334240115314,3.14915,,-0.12110184202319944,,1.5140240789884003,,Uncertain,,Neutral,,0.12586624426754167,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,neutral,,-0.3458,0.1119,-22.2448,-6.02574466933147,0.1233243002268471,Benign,0.6649,pathogenic,-3.94,available,https://doi.org/10.1101/2022.10.22.513328 +P219R,NP_000537:p.Pro219Arg,"hg19,17:g.7578193G>C, hg38,17:g.7674875G>C",,,0.966,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",953426,Uncertain significance,1,,,,,2.0259,0.8147754812240601,1.9269833333333333,-0.14303994816954693,1.9764416666666667,0.9414300259152265,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.42427296736029746,0.428717599384749,0.16270253387544745,2.96108,0.28095,-0.3810511903150518,1.6210149999999999,1.290014404842474,Uncertain,Uncertain,Neutral,Neutral,0.7414525625194552,0.1093935743823209,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,neutral,,-0.3872,0.1119,-22.2448,-7.82669451732048,0.723905110394788,Pathogenic,0.6961,pathogenic,-4.176,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P219S,NP_000537:p.Pro219Ser,"hg19,17:g.7578194G>A, hg38,17:g.7674876G>A",,3.9775665248e-06,0.960,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",245673,Conflicting classifications of pathogenicity,1,,,,,2.64481,0.8977642834186554,2.0619066666666668,0.33440843238479073,2.3533583333333334,1.4896092161923955,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.45053102437420894,0.11575810823532938,0.26621353079142684,3.24331,0.38583000000000006,0.03666357788767854,1.81457,1.6399867889438393,Uncertain,Uncertain,Neutral,Neutral,1.0289708221648788,0.16244791072091191,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,uncertain,,-0.2442,0.1119,-7.957,-4.97570162335351,0.0104918826415043,Benign,0.5148,ambiguous,-3.704,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P219T,NP_000537:p.Pro219Thr,"hg19,17:g.7578194G>T, hg38,17:g.7674876G>T",,,0.962,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2758381,Uncertain significance,1,,,,,2.50218,0.8024100661277771,1.6591833333333332,0.09783289879764567,2.0806816666666665,1.3000064493988228,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.47586831308237104,0.1260448516291809,0.1952939690172673,3.7107,0.14954666666666663,-0.029630490226633294,1.9301233333333334,1.8405347548866835,Uncertain,Uncertain,Neutral,Neutral,0.71998371728502,0.1891178629049824,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,uncertain,,-0.3293,0.1119,-22.2448,-6.95438318069062,0.6524069465970148,Uncertain,0.5899,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P219V,NP_000537:p.Pro219Val,,,,,saturation_mutlist,,,,,,,,2.13194,0.6541944122314454,,-0.4247499097567338,,0.8535950451216332,,Uncertain,Neutral,,Neutral,0.49344984428401684,,0.10587131563078107,3.42559,,-0.3013027857217132,,1.5621436071391435,,Uncertain,,Neutral,,0.34291420991821076,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,neutral,,-0.317,0.1119,-22.2448,-6.41984487557022,0.8301465765786028,Pathogenic,0.7966,pathogenic,-4.495,available,https://doi.org/10.1101/2022.10.22.513328 +P219W,NP_000537:p.Pro219Trp,,,,,saturation_mutlist,,,,,,,,2.11876,0.2726738905906677,,-1.053858751583564,,0.532450624208218,,Uncertain,Neutral,,Neutral,0.5157100251144445,,0.08630215116800569,3.43533,,-1.1207899097611105,,1.1572700451194446,,Uncertain,,Neutral,,0.3739852328116008,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,neutral,,-0.391,0.1119,-22.2448,-7.82669451732048,0.7551148421204195,Pathogenic,0.9584,pathogenic,-4.734,available,https://doi.org/10.1101/2022.10.22.513328 +P219Y,NP_000537:p.Pro219Tyr,,,,,saturation_mutlist,,,,,,,,1.39937,0.25542263746261595,,-0.4988393181740678,,0.4502653409129661,,Neutral,Neutral,,Neutral,0.5638029352044267,,0.08315607091297024,2.81241,,-0.6366645720649855,,1.0878727139675073,,Uncertain,,Neutral,,0.2231674544897298,26.029,9.467,27.67,8.881,,False,26.029,,neutral,neutral,neutral,,False,27.67,,neutral,neutral,neutral,neutral,,-0.3795,0.1119,-22.2448,-7.82669451732048,0.8544565583950675,Pathogenic,0.9331,pathogenic,-4.619,available,https://doi.org/10.1101/2022.10.22.513328 +Y220A,NP_000537:p.Tyr220Ala,,,,,saturation_mutlist,,,,,,,,3.41616,2.4216896200180056,,3.2600932207173208,,3.3381266103586604,,Destabilizing,Destabilizing,,Destabilizing,0.4168210408813587,,0.2827297320045288,-1.74907,,2.4123936004312774,,0.33166180021563874,,Uncertain,,Neutral,,0.5626379755729478,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,neutral,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.4447,0.0798,-22.2419,-6.98521212435209,0.8376702447375943,Pathogenic,0.9905,pathogenic,-4.35,available,https://doi.org/10.1101/2022.10.22.513328 +Y220C,NP_000537:p.Tyr220Cys,"hg19,17:g.7578190T>C, hg19,17:g.7674872T>C, hg38,17:g.7674872T>C",,7.9551963342e-06,0.936,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127819,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,3.05899,1.644521288871765,3.2351466666666666,3.4613464140771892,3.1470683333333334,3.2601682070385944,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.4898467443022194,0.09261120246612833,0.2924150647435826,-1.59646,1.9498866666666668,2.7490517284337854,0.1767133333333334,0.5762958642168927,Neutral,Uncertain,Neutral,Neutral,1.2845399383004366,0.483709884313149,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,neutral,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.4154,0.0798,-22.2419,-6.98521212435209,0.7731185357003707,Pathogenic,0.8515,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y220D,NP_000537:p.Tyr220Asp,"hg19,17:g.7578191A>C, hg19,17:g.7674873A>C, hg38,17:g.7674873A>C",,,0.934,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376689,Conflicting classifications of pathogenicity,1,,,,,4.42716,2.7215098190307616,3.8616766666666664,4.195077349566669,4.144418333333333,4.3111186747833345,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.34884900874983704,0.44297649360760527,0.30207346140399227,-0.33453,3.391383333333333,2.930785675507275,1.5284266666666666,1.2981278377536376,Uncertain,Uncertain,Neutral,Neutral,1.8485148717160909,0.833982940211881,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,neutral,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.4589,0.0798,-22.2419,-6.87859714830146,0.8658325249148415,Pathogenic,0.9974,pathogenic,-4.65,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y220E,NP_000537:p.Tyr220Glu,,,,,saturation_mutlist,,,,,,,,3.71998,2.6847807598114013,,3.7023804498403408,,3.71118022492017,,Destabilizing,Destabilizing,,Destabilizing,0.35412385908333627,,0.2909676962681229,-0.03773,,2.7672344537614166,,1.3647522268807084,,Uncertain,,Neutral,,0.78892620783202,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,neutral,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.4876,0.0798,-22.2419,-6.87859714830146,0.8443098962769138,Pathogenic,0.9987,pathogenic,-4.64,available,https://doi.org/10.1101/2022.10.22.513328 +Y220F,NP_000537:p.Tyr220Phe,,,,,saturation_mutlist,,,,,,,,-0.50812,0.2517982387542725,,0.35273256131907776,,-0.07769371934046113,,Neutral,Neutral,,Neutral,0.2403113815388744,,0.153263323807475,-0.28071,,0.6220128676946253,,0.17065143384731263,,Neutral,,Neutral,,0.29703679395161847,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,damaging,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,uncertain,,-0.2093,0.0798,-7.9541,-2.25535117224147,0.0061200888970215,Benign,0.147,benign,-3.41,available,https://doi.org/10.1101/2022.10.22.513328 +Y220G,NP_000537:p.Tyr220Gly,,,,,saturation_mutlist,,,,,,,,4.53029,2.6330611991882322,,5.021110586507129,,4.775700293253564,,Destabilizing,Destabilizing,,Destabilizing,0.3296142351449332,,0.35641217219559496,-3.37678,,3.6223715807617,,0.12279579038084987,,Uncertain,,Neutral,,0.6925423620874575,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,neutral,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.5153,0.0798,-22.2419,-7.64923818364801,0.8093884567161209,Pathogenic,0.9877,pathogenic,-4.524,available,https://doi.org/10.1101/2022.10.22.513328 +Y220H,NP_000537:p.Tyr220His,"hg19,17:g.7578191A>G, hg19,17:g.7578191_7578192delinsGA, hg19,17:g.7674873A>G, hg38,17:g.7674873A>G",,3.9777247414e-06,0.909,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376687,Pathogenic/Likely pathogenic,2,,,,,2.44944,1.9327158164978027,1.9907033333333333,2.065758299051267,2.2200716666666667,2.2575991495256336,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.24814469039069703,0.32961004357000756,0.1424985502455918,0.5436,1.5078233333333335,1.6000471003664642,1.0257116666666668,1.071823550183232,Neutral,Neutral,Neutral,Neutral,1.0517723404594532,0.5218896740986465,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,uncertain,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.3524,0.0798,-22.2419,-3.40666941627912,0.2179055810843693,Benign,0.9633,pathogenic,-3.751,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y220I,NP_000537:p.Tyr220Ile,,,,,saturation_mutlist,,,,,,,,1.77719,1.619649896621704,,1.8264728080885815,,1.8018314040442909,,Neutral,Uncertain,,Neutral,0.6715208086086711,,0.5178059471580547,0.06423,,1.6233417851733074,,0.8437858925866537,,Neutral,,Neutral,,0.48944843884062045,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,damaging,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.389,0.0798,-8.9541,-3.25072197311028,0.1548710356409479,Benign,0.961,pathogenic,-4.135,available,https://doi.org/10.1101/2022.10.22.513328 +Y220K,NP_000537:p.Tyr220Lys,,,,,saturation_mutlist,,,,,,,,2.57363,2.6303924560546874,,4.178967662182372,,3.3762988310911863,,Uncertain,Destabilizing,,Destabilizing,0.35033855900896665,,0.3160775585140688,-0.19266,,2.7846804698312018,,1.2960102349156009,,Uncertain,,Neutral,,0.8391008160954501,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,uncertain,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.5129,0.0798,-22.2419,-7.64923818364801,0.837933632829506,Pathogenic,0.9989,pathogenic,-4.656,available,https://doi.org/10.1101/2022.10.22.513328 +Y220L,NP_000537:p.Tyr220Leu,,,,,"COSMIC,saturation_mutlist",,,,,,,,0.54686,1.410459234714508,1.4425166666666664,1.3310834558439444,0.9946883333333332,0.9389717279219723,Neutral,Neutral,Uncertain,Neutral,Neutral,0.6815727959538901,0.17902585666756507,0.26798531017364385,-0.87633,2.0807233333333337,1.1465268087137575,0.6021966666666668,0.1350984043568787,Uncertain,Neutral,Neutral,Neutral,1.076556571584709,0.26122134332603425,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,damaging,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.4339,0.0798,-22.2419,-3.10007605983779,0.0549362428711858,Benign,0.8841,pathogenic,-3.783,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y220M,NP_000537:p.Tyr220Met,,,,,saturation_mutlist,,,,,,,,0.18872,1.6000478267669678,,1.7623042809754421,,0.9755121404877211,,Neutral,Uncertain,,Neutral,0.5582400976634082,,0.19419751209998484,-1.64795,,1.3733034160705149,,-0.13732329196474258,,Neutral,,Neutral,,0.26576023929414544,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,damaging,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.3182,0.0798,-8.9541,-3.28843032415183,0.0823672689418071,Benign,0.9687,pathogenic,-4.014,available,https://doi.org/10.1101/2022.10.22.513328 +Y220N,NP_000537:p.Tyr220Asn,"hg19,17:g.7578191A>T, hg19,17:g.7578191_7578192delinsTA, hg19,17:g.7674873A>T, hg38,17:g.7674873A>T",,,0.910,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376688,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,Tier II - Potential,1,3.34837,2.6159197330474853,2.8354866666666667,3.18484482763982,3.0919283333333336,3.26660741381991,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.33883622589087264,0.3495857224709778,0.3353359057172031,-1.20895,1.9167800000000002,2.270550114372532,0.3539150000000001,0.530800057186266,Neutral,Uncertain,Neutral,Neutral,1.5230054302157516,0.6808398049836811,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,neutral,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.4379,0.0798,-22.2419,-6.87859714830146,0.8631746615947256,Pathogenic,0.9869,pathogenic,-4.452,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y220P,NP_000537:p.Tyr220Pro,,,,,saturation_mutlist,,,,,,,,6.71741,2.5193976593017577,,7.852977063999091,,7.285193531999545,,Destabilizing,Destabilizing,,Destabilizing,0.2935738986257763,,0.3932696182179159,2.48944,,6.066743007370714,,4.278091503685356,,Uncertain,,Destabilizing,,2.0705282397647187,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,neutral,uncertain,P,False,38.43,3.12,damaging,uncertain,uncertain,damaging,,-0.5689,0.0798,-22.2419,-7.64923818364801,0.8644042463264392,Pathogenic,0.9963,pathogenic,-4.492,available,https://doi.org/10.1101/2022.10.22.513328 +Y220Q,NP_000537:p.Tyr220Gln,,,,,saturation_mutlist,,,,,,,,2.88871,2.522929072380066,,3.050953488816358,,2.9698317444081788,,Uncertain,Destabilizing,,Uncertain,0.3493652334924753,,0.27387027402794895,-0.19498,,2.373969767944286,,1.089494883972143,,Uncertain,,Neutral,,0.5358045554133374,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,uncertain,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.4624,0.0798,-22.2419,-5.94502452030999,0.6627559958961791,Uncertain,0.9977,pathogenic,-4.166,available,https://doi.org/10.1101/2022.10.22.513328 +Y220R,NP_000537:p.Tyr220Arg,,,,,saturation_mutlist,,,,,,,,2.54204,2.424426693916321,,3.0906690951213087,,2.816354547560654,,Uncertain,Destabilizing,,Uncertain,0.3016567752731374,,0.3422606063763916,0.61012,,2.0627406000333344,,1.336430300016667,,Uncertain,,Neutral,,0.43969720007896973,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,uncertain,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.5083,0.0798,-22.2419,-7.64923818364801,0.8616973762724278,Pathogenic,0.9944,pathogenic,-4.438,available,https://doi.org/10.1101/2022.10.22.513328 +Y220S,NP_000537:p.Tyr220Ser,"hg19,17:g.7578190T>G, hg19,17:g.7674872T>G, hg38,17:g.7674872T>G",,,0.918,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12383,Pathogenic,2,,,Tier I - Strong,1,4.25613,2.5434007835388184,4.411793333333333,4.134905338585083,4.333961666666666,4.195517669292542,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.4009411689745279,0.1467055259884765,0.3229238137746019,-1.73668,2.8989766666666665,2.9409142054878665,0.5811483333333333,0.6021171027439333,Uncertain,Uncertain,Neutral,Neutral,1.0697126191749924,0.8894748501518842,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,neutral,uncertain,P,False,38.43,3.12,uncertain,damaging,uncertain,damaging,,-0.4494,0.0798,-22.2419,-4.64453510359499,0.8278260210664181,Pathogenic,0.9754,pathogenic,-4.262,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y220T,NP_000537:p.Tyr220Thr,,,,,saturation_mutlist,,,,,,,,3.43293,2.391314821243286,,3.3920954404902584,,3.412512720245129,,Destabilizing,Destabilizing,,Destabilizing,0.42838120817149283,,0.35850844507647867,-0.06824,,2.5138453843631012,,1.2228026921815507,,Uncertain,,Neutral,,0.6464705159564922,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,neutral,uncertain,P,False,38.43,3.12,uncertain,damaging,uncertain,damaging,,-0.4681,0.0798,-22.2419,-6.03610522399727,0.6683704482689345,Uncertain,0.991,pathogenic,-4.244,available,https://doi.org/10.1101/2022.10.22.513328 +Y220V,NP_000537:p.Tyr220Val,,,,,saturation_mutlist,,,,,,,,2.33961,1.754730405807495,,2.13835251212375,,2.2389812560618747,,Uncertain,Uncertain,,Uncertain,0.613729957142137,,0.5681486368668114,-0.49193,,1.8316429816908009,,0.6698564908454004,,Neutral,,Neutral,,0.5582007191734862,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,uncertain,uncertain,P,False,38.43,3.12,damaging,damaging,uncertain,damaging,,-0.4463,0.0798,-22.2419,-5.03467392689524,0.3728371322905478,Uncertain,0.9067,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +Y220W,NP_000537:p.Tyr220Trp,,,,,saturation_mutlist,,,,,,,,-0.49713,0.21827995300292968,,0.7528549755493628,,0.12786248777468137,,Neutral,Neutral,,Neutral,0.2445848457037591,,0.30413884962858506,2.38049,,0.7305902196319064,,1.5555401098159531,,Uncertain,,Neutral,,0.2566659032016047,6.204,4.166,38.43,24.876,P,False,6.204,5.103,uncertain,damaging,uncertain,P,False,38.43,3.12,damaging,uncertain,uncertain,neutral,,-0.3623,0.0798,-22.2419,-4.5982958609189,0.8215901885740375,Pathogenic,0.6147,pathogenic,-4.148,available,https://doi.org/10.1101/2022.10.22.513328 +E221A,NP_000537:p.Glu221Ala,"hg19,17:g.7578187T>G, hg38,17:g.7674869T>G",,,0.880,"ClinVar,saturation_mutlist",573679,Uncertain significance,1,,,,,0.32253,0.7759360814094544,0.3329933333333333,0.4968400164260907,0.3277616666666666,0.4096850082130453,Neutral,Neutral,Neutral,Neutral,Neutral,0.16095473993228257,0.16733138803650144,0.13949308636787455,-0.65432,0.1373,0.24669636210096915,-0.25851,-0.20381181894951544,Neutral,Neutral,Neutral,Neutral,0.9787485757162901,0.16401272889856056,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.2355,0.1886,-8.9599,-5.59593430062344,0.2631970581826228,Benign,0.6479,pathogenic,-3.78,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E221C,NP_000537:p.Glu221Cys,,,,,saturation_mutlist,,,,,,,,-0.03344,0.31270385026931763,,1.0231700246718718,,0.4948650123359359,,Neutral,Neutral,,Neutral,0.16431932701107968,,0.19339811312381816,-0.97968,,0.9026126022789933,,-0.03853369886050334,,Neutral,,Neutral,,0.12103721079522749,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.3727,0.1886,-22.2477,-5.73709184939154,0.212968196276467,Benign,0.956,pathogenic,-4.144,available,https://doi.org/10.1101/2022.10.22.513328 +E221D,NP_000537:p.Glu221Asp,"hg38,17:g.7674868C>A, hg38,17:g.7674868C>G",,,0.669,"COSMIC,saturation_mutlist",,,,,,,,0.22662,0.5540435862541199,0.32267666666666667,0.30790940623996516,0.2746483333333333,0.26726470311998257,Neutral,Neutral,Neutral,Neutral,Neutral,0.22026284892052633,0.7989097768139334,0.2787072260827682,-0.22751,0.5899099999999999,0.19555888839937266,0.18119999999999997,-0.015975555800313665,Neutral,Neutral,Neutral,Neutral,1.5966368051000202,0.15188323484548474,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.2012,0.1886,-8.9599,-0.510158117387993,0.0086585152945743,Benign,0.4842,ambiguous,-3.471,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E221F,NP_000537:p.Glu221Phe,,,,,saturation_mutlist,,,,,,,,-0.81718,0.671359715461731,,-0.11065172580579415,,-0.4639158629028971,,Neutral,Neutral,,Neutral,0.26154866212043465,,0.11940823973551205,1.035,,-0.15437710685934486,,0.4403114465703275,,Neutral,,Neutral,,0.12812853943703348,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.3503,0.1886,-22.2477,-6.52075244133916,0.7987544987824662,Pathogenic,0.9697,pathogenic,-4.494,available,https://doi.org/10.1101/2022.10.22.513328 +E221G,NP_000537:p.Glu221Gly,"hg19,17:g.7674869T>C, hg38,17:g.7674869T>C",,,0.826,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.90541,1.2961591267585755,1.6365100000000001,1.2503395661223624,1.27096,1.0778747830611812,Neutral,Neutral,Uncertain,Neutral,Neutral,0.2102577594592082,0.2610534004119974,0.3759592408229521,-0.88357,1.6092966666666666,0.8965803030879881,0.3628633333333333,0.006505151543994059,Neutral,Neutral,Neutral,Neutral,1.0608988534047699,0.11932082828929826,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.3291,0.1886,-22.2477,-5.94248562830314,0.2103720282459079,Benign,0.7281,pathogenic,-3.814,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E221H,NP_000537:p.Glu221His,,,,,saturation_mutlist,,,,,,,,-0.25821,0.6777213025093078,,0.014790008664685004,,-0.1217099956676575,,Neutral,Neutral,,Neutral,0.20491724483689744,,0.15300515071515247,1.23895,,-0.153317307050063,,0.5428163464749685,,Neutral,,Neutral,,0.2052389863808307,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.3416,0.1886,-22.2477,-5.82212209907457,0.3459677636633074,Uncertain,0.8882,pathogenic,-3.974,available,https://doi.org/10.1101/2022.10.22.513328 +E221I,NP_000537:p.Glu221Ile,,,,,saturation_mutlist,,,,,,,,-0.63121,0.4409676241874695,,-0.049087428931242405,,-0.3401487144656212,,Neutral,Neutral,,Neutral,0.1888409055431644,,0.15088417971394505,0.08555,,-0.10771157728574154,,-0.011080788642870772,,Neutral,,Neutral,,0.0672210380135332,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.3557,0.1886,-22.2477,-6.59482766227259,0.6433239782697077,Uncertain,0.8022,pathogenic,-4.322,available,https://doi.org/10.1101/2022.10.22.513328 +E221K,NP_000537:p.Glu221Lys,"hg19,17:g.7578188C>T, hg38,17:g.7674870C>T",,3.9780095631e-06,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",184647,Uncertain significance,2,,,,,-0.48733,0.8564795684814454,-0.14931999999999998,0.4015311568498956,-0.31832499999999997,-0.04289942157505219,Neutral,Neutral,Neutral,Neutral,Neutral,0.2599634998541159,0.5504170305020246,0.24011960910292085,-0.15528,-0.051136666666666664,0.12232985731968123,-0.10320833333333333,-0.016475071340159388,Neutral,Neutral,Neutral,Neutral,0.220521191926964,0.09745244485437728,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.2575,0.1886,-8.9599,-2.48019949466779,0.0509590519823074,Benign,0.7104,pathogenic,-3.98,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E221L,NP_000537:p.Glu221Leu,,,,,saturation_mutlist,,,,,,,,-0.62851,0.5535397076606751,,-0.2354961427959116,,-0.4320030713979558,,Neutral,Neutral,,Neutral,0.18899983152730607,,0.15024111204535226,-0.58509,,-0.4428512172273724,,-0.5139706086136862,,Neutral,,Neutral,,0.20368450009493763,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.3578,0.1886,-22.2477,-6.11604798614406,0.4309748658286487,Uncertain,0.8355,pathogenic,-4.023,available,https://doi.org/10.1101/2022.10.22.513328 +E221M,NP_000537:p.Glu221Met,"hg19,17:g.7578187_7578188delinsAT, hg38,17:g.7674869_7674870delinsAT",,,,"ClinVar,saturation_mutlist",2824912,Uncertain significance,1,,,,,-0.80879,0.6604283332824707,,0.13133461679684985,,-0.33872769160157506,,Neutral,Neutral,,Neutral,0.15684578988294035,,0.1345993531453511,-0.82253,,-0.04753867310726576,,-0.4350343365536329,,Neutral,,Neutral,,0.20650701093401286,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.3066,0.1886,-22.2477,-6.92433865170428,0.8566867833812014,Pathogenic,0.8436,pathogenic,-4.392,available,https://doi.org/10.1101/2022.10.22.513328 +E221N,NP_000537:p.Glu221Asn,,,,,saturation_mutlist,,,,,,,,-0.11382,0.7773159265518188,,0.3602668028511074,,0.1232234014255537,,Neutral,Neutral,,Neutral,0.2450263422250944,,0.22519736966092738,-0.63094,,0.13931493324824681,,-0.24581253337587655,,Neutral,,Neutral,,0.25371634312931873,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.3295,0.1886,-22.2477,-3.6224616095687,0.0939398907455993,Benign,0.7825,pathogenic,-3.88,available,https://doi.org/10.1101/2022.10.22.513328 +E221P,NP_000537:p.Glu221Pro,,,,,saturation_mutlist,,,,,,,,1.00799,1.7441379117965699,,2.3076892033479024,,1.6578396016739512,,Uncertain,Uncertain,,Neutral,0.38375859916735516,,0.7259362000203349,1.11074,,1.5739935213831435,,1.3423667606915717,,Neutral,,Neutral,,0.5754552096509717,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.4603,0.1886,-22.2477,-7.5825594103199,0.8182847858013036,Pathogenic,0.9769,pathogenic,-4.12,available,https://doi.org/10.1101/2022.10.22.513328 +E221Q,NP_000537:p.Glu221Gln,,,,,saturation_mutlist,,,,,,,,-0.3831,0.433793203830719,,0.3857008856847441,,0.001300442842372046,,Neutral,Neutral,,Neutral,0.1715475006502366,,0.12346556858606984,-0.3654,,0.21625288067597148,,-0.07457355966201426,,Neutral,,Neutral,,0.14673478649212926,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.1978,0.1886,-6.96,-2.45338590443034,0.0008066636635304,Benign,0.4052,ambiguous,-3.496,available,https://doi.org/10.1101/2022.10.22.513328 +E221R,NP_000537:p.Glu221Arg,,,,,saturation_mutlist,,,,,,,,-0.58061,0.9819811367988587,,0.1838428081422274,,-0.19838359592888627,,Neutral,Neutral,,Neutral,0.2595652791876654,,0.17689400862375582,0.47392,,-0.09548133763909393,,0.18921933118045303,,Neutral,,Neutral,,0.17625996864295324,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.3858,0.1886,-22.2477,-5.32530863535971,0.4005721487426265,Uncertain,0.7804,pathogenic,-3.966,available,https://doi.org/10.1101/2022.10.22.513328 +E221S,NP_000537:p.Glu221Ser,,,,,saturation_mutlist,,,,,,,,0.15004,0.5165644526481629,,0.6209602267598952,,0.3855001133799476,,Neutral,Neutral,,Neutral,0.18110530571821473,,0.28863579714891774,-0.79448,,0.3103287160209903,,-0.24207564198950482,,Neutral,,Neutral,,0.12143105346123644,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.2439,0.1886,-7.9599,-3.54897606682575,0.0283479585202205,Benign,0.6446,pathogenic,-3.584,available,https://doi.org/10.1101/2022.10.22.513328 +E221T,NP_000537:p.Glu221Thr,,,,,saturation_mutlist,,,,,,,,-0.05351,0.17355263710021973,,0.40774426890807863,,0.17711713445403932,,Neutral,Neutral,,Neutral,0.18591225517246854,,0.123766735681356,0.18514,,0.22621045734751297,,0.20567522867375648,,Neutral,,Neutral,,0.12237626681563882,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.2649,0.1886,-8.9599,-3.50966861286784,0.0460218119494903,Benign,0.6731,pathogenic,-3.752,available,https://doi.org/10.1101/2022.10.22.513328 +E221V,NP_000537:p.Glu221Val,"hg38,17:g.7674869T>A",,,0.901,"COSMIC,saturation_mutlist",,,,,,,,-0.12705,0.3101381754875183,-0.5449,0.013181441236692468,-0.335975,-0.05693427938165376,Neutral,Neutral,Neutral,Neutral,Neutral,0.19624829670148242,0.2568098652051098,0.08992437335466132,0.02916,0.5276633333333334,0.0698488137550085,0.27841166666666667,0.04950440687750425,Neutral,Neutral,Neutral,Neutral,1.4300275406516554,0.08724086757046579,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.3166,0.1886,-22.2477,-6.92433865170428,0.773417038277459,Pathogenic,0.6334,pathogenic,-4.098,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E221W,NP_000537:p.Glu221Trp,,,,,saturation_mutlist,,,,,,,,-0.66006,0.7700574040412903,,-0.39964042963485696,,-0.5298502148174284,,Neutral,Neutral,,Neutral,0.2484878551709539,,0.12708866074000014,2.91167,,-0.4526601444965867,,1.2295049277517067,,Uncertain,,Neutral,,0.12002672205127209,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.3604,0.1886,-22.2477,-6.52075244133916,0.7462972882761,Pathogenic,0.9915,pathogenic,-4.509,available,https://doi.org/10.1101/2022.10.22.513328 +E221Y,NP_000537:p.Glu221Tyr,,,,,saturation_mutlist,,,,,,,,-0.77764,0.725356822013855,,-0.03723388108789543,,-0.4074369405439477,,Neutral,Neutral,,Neutral,0.2680390365004748,,0.11310814304430047,1.72509,,-0.0378199712656646,,0.8436350143671677,,Neutral,,Neutral,,0.11024280014415941,57.193,11.332,52.865,29.521,,False,57.193,,neutral,neutral,neutral,,False,52.865,,neutral,neutral,neutral,uncertain,,-0.3512,0.1886,-22.2477,-6.52075244133916,0.7773936456538608,Pathogenic,0.9574,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +P222A,NP_000537:p.Pro222Ala,"hg38,17:g.7674867G>C",,,0.395,"COSMIC,saturation_mutlist",,,,,,,,2.13023,0.6157802629470825,1.1464833333333333,0.21780435941345713,1.6383566666666667,1.1740171797067287,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.27781774632612627,0.3727916166200928,0.28864748004393587,1.9388,1.3205200000000001,0.950980437821317,1.62966,1.4448902189106585,Neutral,Neutral,Neutral,Neutral,0.42265006715563963,0.49849549077079564,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.1255,1.2061,-4.375,-1.99439351178775,2.391935255166569e-07,Benign,0.0808,benign,-3.112,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P222C,NP_000537:p.Pro222Cys,,,,,saturation_mutlist,,,,,,,,2.32741,0.6208359241485596,,0.9554008136260462,,1.641405406813023,,Uncertain,Neutral,,Neutral,0.29516440111867676,,0.35302182950915256,2.52332,,1.1361312952380118,,1.8297256476190058,,Uncertain,,Neutral,,0.3697155380444444,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,uncertain,,-0.1765,1.2061,-7.9599,-2.02411212241074,0.001071223980196,Benign,0.3919,ambiguous,-3.833,available,https://doi.org/10.1101/2022.10.22.513328 +P222D,NP_000537:p.Pro222Asp,,,,,saturation_mutlist,,,,,,,,2.92638,1.1876963567733765,,0.5940445681105825,,1.7602122840552912,,Uncertain,Uncertain,,Neutral,0.41363512097780575,,0.5245676745933794,4.29383,,1.6784501666270903,,2.986140083313545,,Uncertain,,Uncertain,,0.9898564065222161,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,uncertain,,-0.2753,1.2061,-22.2477,-3.083358929793,0.0017495402429779,Benign,0.4956,ambiguous,-3.884,available,https://doi.org/10.1101/2022.10.22.513328 +P222E,NP_000537:p.Pro222Glu,,,,,saturation_mutlist,,,,,,,,2.28235,0.9480859339237213,,0.34900150099534444,,1.3156757504976722,,Uncertain,Neutral,,Neutral,0.4405258034175562,,0.5192014515532978,4.53242,,1.3966985360099133,,2.964559268004957,,Uncertain,,Uncertain,,0.9989507694982152,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.1913,1.2061,-8.9599,-3.6155304032592,8.998455961880043e-07,Benign,0.2873,benign,-3.542,available,https://doi.org/10.1101/2022.10.22.513328 +P222F,NP_000537:p.Pro222Phe,,,,,saturation_mutlist,,,,,,,,1.81681,0.9927642464637756,,-0.09908074665701279,,0.8588646266714937,,Neutral,Neutral,,Neutral,0.40351708044219836,,0.33796340833461036,7.56093,,-0.23074611532763986,,3.66509194233618,,Uncertain,,Destabilizing,,1.003346590630082,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.2779,1.2061,-22.2477,-4.50963856483679,0.0252823042548482,Benign,0.4084,ambiguous,-3.906,available,https://doi.org/10.1101/2022.10.22.513328 +P222G,NP_000537:p.Pro222Gly,,,,,saturation_mutlist,,,,,,,,2.73653,1.2314746904373168,,1.092861347564828,,1.914695673782414,,Uncertain,Uncertain,,Neutral,0.2484182303020435,,0.1684302786791879,1.39486,,2.1085768052958223,,1.7517184026479111,,Uncertain,,Neutral,,0.9801553937129319,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.1552,1.2061,-7.375,-2.75766113939397,0.0001067030283119,Benign,0.2928,benign,-3.496,available,https://doi.org/10.1101/2022.10.22.513328 +P222H,NP_000537:p.Pro222His,,,,,saturation_mutlist,,,,,,,,2.49689,0.907965030670166,,-0.0701827853154417,,1.2133536073422793,,Uncertain,Neutral,,Neutral,0.34922460326363625,,0.3443190898558423,7.98381,,0.4978923907136464,,4.240851195356823,,Uncertain,,Destabilizing,,0.9144407759776224,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.1758,1.2061,-6.6381,-2.8801891834461,6.587257282736675e-05,Benign,0.2007,benign,-3.374,available,https://doi.org/10.1101/2022.10.22.513328 +P222I,NP_000537:p.Pro222Ile,,,,,saturation_mutlist,,,,,,,,2.1554,0.9395639014244079,,-0.011244413110945123,,1.0720777934445276,,Uncertain,Neutral,,Neutral,0.34501804511768325,,0.3506376533150033,4.39528,,-0.08708693519205403,,2.154096532403973,,Uncertain,,Uncertain,,0.018155482826851477,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.1931,1.2061,-8.9599,-3.67786415987998,0.0018139773314071,Benign,0.2769,benign,-3.761,available,https://doi.org/10.1101/2022.10.22.513328 +P222K,NP_000537:p.Pro222Lys,,,,,saturation_mutlist,,,,,,,,1.69881,0.8381292223930359,,0.16005844073535788,,0.9294342203676789,,Neutral,Neutral,,Neutral,0.3000744653240577,,0.2707330147866962,4.38246,,2.106041390020192,,3.2442506950100958,,Uncertain,,Destabilizing,,1.5528415804067233,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.1712,1.2061,-6.6381,-2.793301112349,2.9979821356448064e-06,Benign,0.2985,benign,-3.476,available,https://doi.org/10.1101/2022.10.22.513328 +P222L,NP_000537:p.Pro222Leu,"hg19,17:g.7578184G>A, hg38,17:g.7674866G>A, hg38,17:g.7674866_7674867delinsAA",6.37226789014e-05,1.59154570919e-05,0.585,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",161397,Conflicting classifications of pathogenicity,1,,,,,1.83499,0.8906774544715881,0.53061,-0.2381769440826148,1.1827999999999999,0.7984065279586925,Neutral,Neutral,Neutral,Neutral,Neutral,0.40699484186744495,1.4819350152418964,0.3045417064204714,2.70678,0.25226666666666664,-0.491920991200605,1.4795233333333333,1.1074295043996976,Uncertain,Uncertain,Neutral,Neutral,1.1531271206111184,0.2806873199065668,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.1845,1.2061,-6.375,-1.39143923387326,6.50720818059762e-08,Benign,0.0964,benign,-3.316,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P222M,NP_000537:p.Pro222Met,,,,,saturation_mutlist,,,,,,,,1.46897,0.9239012527465821,,0.012779666777534643,,0.7408748333887674,,Neutral,Neutral,,Neutral,0.34164685499585773,,0.25252133666161486,2.27161,,-0.04047527079403801,,1.115567364602981,,Uncertain,,Neutral,,0.4262916331194721,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.1384,1.2061,-6.96,-2.59893132126097,0.0002073534908524,Benign,0.2249,benign,-3.607,available,https://doi.org/10.1101/2022.10.22.513328 +P222N,NP_000537:p.Pro222Asn,,,,,saturation_mutlist,,,,,,,,2.58331,1.0365045404434203,,0.2612172225170753,,1.4222636112585376,,Uncertain,Uncertain,,Neutral,0.29759746354129246,,0.3055362956080526,3.22484,,0.9138948402979755,,2.069367420148988,,Uncertain,,Uncertain,,0.5791393367523904,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,uncertain,,-0.2435,1.2061,-22.2477,-3.08376196317857,0.0017564444981529,Benign,0.3124,benign,-3.637,available,https://doi.org/10.1101/2022.10.22.513328 +P222Q,NP_000537:p.Pro222Gln,"hg19,17:g.7578184G>T, hg38,17:g.7674866G>T",,,0.626,"COSMIC,ClinVar,saturation_mutlist",1461784,Uncertain significance,1,,,,,2.08342,0.883912136554718,1.1476199999999999,0.4260681996806615,1.6155199999999998,1.2547440998403308,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.2947114634253007,0.7975562875433935,0.43246107401346284,3.82392,0.82109,0.916519357689585,2.322505,2.3702196788447925,Uncertain,Uncertain,Uncertain,Uncertain,0.8410159373440356,0.6472810348899335,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.1723,1.2061,-7.9599,-2.72420196645075,0.0003169390472358,Benign,0.1551,benign,-3.329,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P222R,NP_000537:p.Pro222Arg,,,,,saturation_mutlist,,,,,,,,1.724,0.9237566208839416,,-0.03339154300305049,,0.8453042284984748,,Neutral,Neutral,,Neutral,0.32189507450624766,,0.25733484998583295,5.84564,,1.4248690874872405,,3.6352545437436206,,Uncertain,,Destabilizing,,1.2931030001626551,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.2056,1.2061,-6.375,-2.80233565190028,7.886288967924056e-06,Benign,0.1863,benign,-3.448,available,https://doi.org/10.1101/2022.10.22.513328 +P222S,NP_000537:p.Pro222Ser,"hg19,17:g.7578185G>A, hg38,17:g.7674867G>A",,,0.344,"COSMIC,ClinVar,saturation_mutlist",406592,Conflicting classifications of pathogenicity,1,,,,,2.61041,0.8041856586933136,1.1223333333333334,0.39755057067780175,1.8663716666666668,1.5039802853389008,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.2387669010027714,0.16304818558396236,0.358641849313763,2.97526,1.64796,1.4920893197192473,2.31161,2.2336746598596235,Uncertain,Uncertain,Uncertain,Uncertain,0.7927140217421834,0.833326114499582,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.1298,1.2061,-5.2596,-0.961746201173931,7.118360159508328e-09,Benign,0.1373,benign,-3.13,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P222T,NP_000537:p.Pro222Thr,"hg38,17:g.7674867G>T",,,0.533,"COSMIC,saturation_mutlist",,,,,,,,2.73728,1.0448446369171143,0.5660966666666667,0.3652164825977944,1.6516883333333334,1.5512482412988973,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.33112252362173616,1.002158496125017,0.4608111590412189,3.87979,0.75873,0.9369917525770743,2.31926,2.408390876288537,Uncertain,Uncertain,Uncertain,Uncertain,1.2916158433786211,0.539520395006264,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,uncertain,,-0.1438,1.2061,-5.6381,-1.0716492687091,4.918684802531932e-07,Benign,0.1178,benign,-3.262,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P222V,NP_000537:p.Pro222Val,,,,,saturation_mutlist,,,,,,,,2.40475,0.9359123277664184,,0.11462602875494608,,1.259688014377473,,Uncertain,Neutral,,Neutral,0.3623230120092295,,0.39460566871057473,3.59469,,0.0907803367952969,,1.8427351683976485,,Uncertain,,Neutral,,0.08490298111424992,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.1485,1.2061,-8.9599,-3.51861341178905,0.0083152950804751,Benign,0.1847,benign,-3.581,available,https://doi.org/10.1101/2022.10.22.513328 +P222W,NP_000537:p.Pro222Trp,,,,,saturation_mutlist,,,,,,,,2.70794,0.9708740544319153,,-0.40268039421185026,,1.1526298028940747,,Uncertain,Neutral,,Neutral,0.44627579260335704,,0.2649086572057693,10.75827,,0.3552642958730731,,5.556767147936537,,Uncertain,,Destabilizing,,1.424252059509408,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.2904,1.2061,-22.2477,-4.70625338737446,0.317707952343677,Benign,0.5836,pathogenic,-4.176,available,https://doi.org/10.1101/2022.10.22.513328 +P222Y,NP_000537:p.Pro222Tyr,,,,,saturation_mutlist,,,,,,,,2.10379,0.8662737774848938,,0.032886321023635035,,1.0683381605118176,,Uncertain,Neutral,,Neutral,0.429671633664461,,0.3234231792490995,9.7987,,0.35099088252714256,,5.074845441263571,,Uncertain,,Destabilizing,,1.2219583051569398,38.064,13.685,23.495,24.249,,True,38.064,,neutral,neutral,neutral,,True,23.495,,neutral,neutral,neutral,damaging,,-0.211,1.2061,-8.9599,-2.79555956549886,0.0008931454372717,Benign,0.4246,ambiguous,-3.79,available,https://doi.org/10.1101/2022.10.22.513328 +P223A,NP_000537:p.Pro223Ala,"hg38,17:g.7674864G>C",,,0.759,"COSMIC,saturation_mutlist",,,,,,,,1.57924,0.5691046214103699,0.8670066666666667,0.24270179409034212,1.2231233333333333,0.9109708970451711,Neutral,Neutral,Neutral,Neutral,Neutral,0.4590948753882619,0.36415998556800405,0.10454100402469196,1.28369,0.23004333333333338,0.4644453567743089,0.7568666666666667,0.8740676783871545,Neutral,Neutral,Neutral,Neutral,1.0367858320898402,0.2707590736542969,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.322,0.0627,-22.2477,-6.17373289280236,0.4471511683644641,Uncertain,0.495,ambiguous,-3.732,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P223C,NP_000537:p.Pro223Cys,,,,,saturation_mutlist,,,,,,,,1.98055,0.7198560166358948,,0.771055031648094,,1.375802515824047,,Neutral,Neutral,,Neutral,0.43213074668980983,,0.013222662372219248,2.34324,,0.8591235524348481,,1.601181776217424,,Uncertain,,Neutral,,0.0546923496716967,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,uncertain,,-0.3546,0.0627,-22.2477,-7.03931855218659,0.7271140237400785,Pathogenic,0.9401,pathogenic,-4.107,available,https://doi.org/10.1101/2022.10.22.513328 +P223D,NP_000537:p.Pro223Asp,,,,,saturation_mutlist,,,,,,,,2.68955,1.7401398515701294,,0.5551811492676494,,1.6223655746338248,,Uncertain,Uncertain,,Neutral,0.6956488423158218,,0.38677522588095775,5.08419,,0.30404563389736966,,2.694117816948685,,Uncertain,,Uncertain,,0.33874879852137946,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,uncertain,,-0.3805,0.0627,-22.2477,-7.31200265301887,0.8579089479537727,Pathogenic,0.992,pathogenic,-4.326,available,https://doi.org/10.1101/2022.10.22.513328 +P223E,NP_000537:p.Pro223Glu,,,,,saturation_mutlist,,,,,,,,2.31317,1.399764473438263,,0.44376814934702385,,1.378469074673512,,Uncertain,Uncertain,,Neutral,0.4981161256776823,,0.20790124024912326,7.10037,,0.4236752910429283,,3.7620226455214643,,Uncertain,,Destabilizing,,0.36947269948520756,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.3644,0.0627,-22.2477,-7.31200265301887,0.6981858230877793,Pathogenic,0.9687,pathogenic,-4.332,available,https://doi.org/10.1101/2022.10.22.513328 +P223F,NP_000537:p.Pro223Phe,,,,,saturation_mutlist,,,,,,,,1.81502,1.2041753792762757,,-0.24741591136645813,,0.783802044316771,,Neutral,Uncertain,,Neutral,0.5822020496257119,,0.18208615518468088,11.09158,,-0.08223124283501304,,5.504674378582494,,Uncertain,,Destabilizing,,0.1962689332722747,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.3831,0.0627,-22.2477,-7.1544350587756,0.6803122835284147,Pathogenic,0.9914,pathogenic,-4.14,available,https://doi.org/10.1101/2022.10.22.513328 +P223G,NP_000537:p.Pro223Gly,,,,,saturation_mutlist,,,,,,,,2.02086,1.4285753464698792,,1.0086237938063414,,1.5147418969031707,,Uncertain,Uncertain,,Neutral,0.47258035485953637,,0.08395563245382198,0.44429,,0.821974729812093,,0.6331323649060465,,Neutral,,Neutral,,0.43247215270700523,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.2685,0.0627,-8.9599,-8.13005495551572,0.7348524966380978,Pathogenic,0.9275,pathogenic,-3.929,available,https://doi.org/10.1101/2022.10.22.513328 +P223H,NP_000537:p.Pro223His,"hg19,17:g.7578181G>T, hg38,17:g.7674863G>T",,3.9792442619e-06,0.728,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.56267,1.2940254878997803,1.5402500000000001,-0.054145840090379205,2.05146,1.2542620799548103,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.532227582587346,0.603761932056005,0.14061649879393393,10.82873,-0.52653,-0.156353874236866,5.1511000000000005,5.336188062881567,Uncertain,Uncertain,Destabilizing,Destabilizing,1.1348419956980795,0.09509781844468346,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.2929,0.0627,-8.9599,-7.32700846970999,0.7223798283739538,Pathogenic,0.9636,pathogenic,-4.038,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P223I,NP_000537:p.Pro223Ile,,,,,saturation_mutlist,,,,,,,,2.38588,1.1829757905006408,,0.00999562680557233,,1.197937813402786,,Uncertain,Uncertain,,Neutral,0.5662536075163993,,0.14569908182924562,6.23764,,0.32448216374876493,,3.281061081874382,,Uncertain,,Destabilizing,,0.0720316080649198,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.3661,0.0627,-22.2477,-7.06470800640211,0.8640871726998501,Pathogenic,0.9709,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +P223K,NP_000537:p.Pro223Lys,,,,,saturation_mutlist,,,,,,,,1.78731,1.1882588624954225,,0.3541867946854403,,1.07074839734272,,Neutral,Uncertain,,Neutral,0.4045968990506073,,0.2787285660847588,5.7752,,0.27409732394352787,,3.024648661971764,,Uncertain,,Destabilizing,,0.16465360873385654,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.356,0.0627,-22.2477,-8.13005495551572,0.8571357115504532,Pathogenic,0.977,pathogenic,-4.35,available,https://doi.org/10.1101/2022.10.22.513328 +P223L,NP_000537:p.Pro223Leu,"hg19,17:g.7578181G>A, hg19,17:g.7674863G>A, hg38,17:g.7674863G>A",,,0.634,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",234214,Uncertain significance,2,,,,,1.84315,1.2263337588310241,1.579023333333333,-0.273206808631,1.7110866666666666,0.7849715956845,Neutral,Neutral,Uncertain,Neutral,Neutral,0.5603190269962323,1.0603058126890665,0.1101293866144844,5.64344,-0.4639433333333333,-0.25439799951471204,2.5897483333333335,2.694521000242644,Uncertain,Uncertain,Uncertain,Uncertain,0.7091650391990725,0.13963224291114368,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.3029,0.0627,-8.9599,-4.36242532907302,0.0178880842883156,Benign,0.838,pathogenic,-3.606,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P223M,NP_000537:p.Pro223Met,,,,,saturation_mutlist,,,,,,,,1.58114,1.1394263458251954,,0.038108725858435395,,0.8096243629292177,,Neutral,Uncertain,,Neutral,0.47815560503122,,0.12384007642251971,4.55233,,0.06047407313385916,,2.3064020365669298,,Uncertain,,Uncertain,,0.20209075844675442,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.3217,0.0627,-22.2477,-7.06470800640211,0.7950913867305037,Pathogenic,0.9631,pathogenic,-4.381,available,https://doi.org/10.1101/2022.10.22.513328 +P223N,NP_000537:p.Pro223Asn,,,,,saturation_mutlist,,,,,,,,2.14132,1.45757221698761,,0.2451470130440461,,1.193233506522023,,Uncertain,Uncertain,,Neutral,0.5238158130178477,,0.3482525040124179,4.58566,,0.042580858255586634,,2.3141204291277933,,Uncertain,,Uncertain,,0.1298680240875326,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,uncertain,,-0.3487,0.0627,-22.2477,-6.70063033398526,0.6757062470270164,Uncertain,0.9869,pathogenic,-4.051,available,https://doi.org/10.1101/2022.10.22.513328 +P223Q,NP_000537:p.Pro223Gln,,,,,saturation_mutlist,,,,,,,,2.09608,1.2444635653495788,,0.43718069912302365,,1.2666303495615119,,Uncertain,Uncertain,,Neutral,0.4435776901950275,,0.1335335744113501,6.0854,,0.39385165773563235,,3.2396258288678164,,Uncertain,,Destabilizing,,0.18959188937190818,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.3504,0.0627,-22.2477,-7.31200265301887,0.572686355119146,Uncertain,0.9404,pathogenic,-3.96,available,https://doi.org/10.1101/2022.10.22.513328 +P223R,NP_000537:p.Pro223Arg,"hg38,17:g.7674863G>C",,,0.740,"COSMIC,saturation_mutlist",,,,,,,,1.89454,1.2740164613723755,1.0876433333333333,-0.017266634115281065,1.4910916666666667,0.9386366829423594,Neutral,Neutral,Uncertain,Neutral,Neutral,0.4389352011362188,0.8023208431516381,0.23925404631202837,7.21613,0.7972800000000002,0.03486412187158727,4.006705,3.6254970609357935,Uncertain,Uncertain,Destabilizing,Destabilizing,3.1189078781308477,0.1640257668665952,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.3918,0.0627,-22.2477,-8.13005495551572,0.8702323619500463,Pathogenic,0.9182,pathogenic,-4.222,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P223S,NP_000537:p.Pro223Ser,"hg19,17:g.7578182G>A, hg19,17:g.7674864G>A, hg38,17:g.7674864G>A",,,0.765,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.19017,0.9984043097496033,1.443196666666667,0.38236445159019655,1.8166833333333336,1.2862672257950984,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.4447416223375786,0.39823439616498335,0.025509252396994954,1.75033,-0.23254000000000005,0.49424934666913267,0.758895,1.1222896733345662,Neutral,Neutral,Neutral,Neutral,1.5280127733323,0.3592848276240467,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.3217,0.0627,-22.2477,-5.11965140933339,0.1453155685998165,Benign,0.8509,pathogenic,-3.594,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P223T,NP_000537:p.Pro223Thr,"hg19,17:g.7578182G>T",,,0.786,"cBioPortal,saturation_mutlist",,,,,,,,2.5589,1.1685502409934998,1.4794766666666668,0.3254515396558945,2.019188333333333,1.4421757698279472,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.5321019045667572,0.6986666725667939,0.0697955250228438,4.26872,-0.8388866666666667,0.6124170875094662,1.7149166666666666,2.440568543754733,Uncertain,Uncertain,Neutral,Uncertain,1.6290438290059057,0.1587961854776606,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,uncertain,,-0.3338,0.0627,-22.2477,-6.53497147428304,0.6637775410532785,Uncertain,0.8645,pathogenic,-3.865,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P223V,NP_000537:p.Pro223Val,,,,,saturation_mutlist,,,,,,,,2.40524,1.0357908010482788,,0.031544455862324204,,1.218392227931162,,Uncertain,Uncertain,,Neutral,0.6008597865552837,,0.1110086414225776,4.5153,,0.45958870058754836,,2.487444350293774,,Uncertain,,Uncertain,,0.15963452658529304,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.3215,0.0627,-22.2477,-6.85857708020615,0.5864770402733357,Uncertain,0.8961,pathogenic,-3.939,available,https://doi.org/10.1101/2022.10.22.513328 +P223W,NP_000537:p.Pro223Trp,,,,,saturation_mutlist,,,,,,,,2.50323,1.3037658405303956,,-0.6275071115004724,,0.9378614442497637,,Uncertain,Uncertain,,Neutral,0.5952853300294904,,0.17398256110938154,16.82053,,-0.31135617820476397,,8.254586910897618,,Uncertain,,Destabilizing,,0.16165714000973364,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.3956,0.0627,-22.2477,-7.58468675385115,0.7738520271856457,Pathogenic,0.9927,pathogenic,-4.586,available,https://doi.org/10.1101/2022.10.22.513328 +P223Y,NP_000537:p.Pro223Tyr,,,,,saturation_mutlist,,,,,,,,1.9621,1.1969366908073424,,-0.13185120374026524,,0.9151243981298673,,Neutral,Uncertain,,Neutral,0.5276772458312954,,0.23459173051869112,11.1827,,0.07404045552961981,,5.62837022776481,,Uncertain,,Destabilizing,,0.18659079550307514,33.853,10.975,11.16,11.087,,True,33.853,,neutral,neutral,neutral,,True,11.16,,neutral,neutral,neutral,neutral,,-0.3841,0.0627,-22.2477,-7.58468675385115,0.7045413460683825,Pathogenic,0.9909,pathogenic,-4.304,available,https://doi.org/10.1101/2022.10.22.513328 +E224A,NP_000537:p.Glu224Ala,"hg19,17:g.7578178T>G, hg38,17:g.7674860T>G",,,0.825,"cBioPortal,ClinVar,saturation_mutlist",428892,Uncertain significance,2,,,,,0.32474,-0.10589289426803589,0.16383333333333333,0.25490018315747837,0.24428666666666665,0.28982009157873917,Neutral,Neutral,Neutral,Neutral,Neutral,0.16287989477538478,0.09441102525070305,0.009278258432431009,-0.37999,-0.60034,0.6780229950725851,-0.49016499999999996,0.14901649753629256,Neutral,Neutral,Neutral,Neutral,0.11468622003827077,0.17138386520064752,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2464,0.8075,-22.2477,-5.87663873434466,0.0551339210489787,Benign,0.6237,pathogenic,-3.504,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E224C,NP_000537:p.Glu224Cys,,,,,saturation_mutlist,,,,,,,,0.41786,-0.09146048307418822,,0.7483134869080392,,0.5830867434540197,,Neutral,Neutral,,Neutral,0.12906449606198037,,0.01931429235929492,-0.29955,,1.097273595275488,,0.398861797637744,,Neutral,,Neutral,,0.06791696075876764,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.3158,0.8075,-22.2477,-6.51966851149614,0.8356706236209989,Pathogenic,0.9819,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328 +E224D,NP_000537:p.Glu224Asp,"hg19,17:g.7578177C>A, hg19,17:g.7578177C>G, hg19,17:g.7674859C>A, hg19,17:g.7674859C>G, hg38,17:g.7674859C>A, hg38,17:g.7674859C>G",,3.9807649438e-06,0.697,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","1493447, 635390","Uncertain significance, Conflicting classifications of pathogenicity","1, 1",Uncertain significance,1,,,0.12077,0.16973945021629333,0.025056666666666633,-0.0832754149148013,0.07291333333333332,0.018747292542599353,Neutral,Neutral,Neutral,Neutral,Neutral,0.15109820809943797,0.4325696848935312,0.15448044769848326,0.31694,0.3710866666666666,0.5942493368858588,0.3440133333333333,0.4555946684429294,Neutral,Neutral,Neutral,Neutral,0.4098552708240096,0.14645609611759386,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.1443,0.8075,-8.9599,-3.60034930259215,0.0830750869694919,Benign,0.8106,pathogenic,-3.568,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E224F,NP_000537:p.Glu224Phe,,,,,saturation_mutlist,,,,,,,,0.19903,0.14304707765579225,,-0.1424570602673728,,0.028286469866313613,,Neutral,Neutral,,Neutral,0.1625065624472141,,0.0852687265456524,0.3016,,0.25078737848143073,,0.27619368924071536,,Neutral,,Neutral,,0.17630486354597183,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2934,0.8075,-22.2477,-6.67883821107086,0.7605456754528067,Pathogenic,0.9931,pathogenic,-4.256,available,https://doi.org/10.1101/2022.10.22.513328 +E224G,NP_000537:p.Glu224Gly,"hg19,17:g.7578178T>C, hg38,17:g.7674860T>C",,,0.890,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",826574,Uncertain significance,2,,,,,0.22844,0.10874860525131226,0.5784566666666667,0.6869550366406157,0.40344833333333335,0.45769751832030786,Neutral,Neutral,Neutral,Neutral,Neutral,0.19337891528432338,0.22178094603058718,0.14304401403137393,-1.06703,0.20272333333333337,1.2360945198965088,-0.4321533333333333,0.08453225994825442,Neutral,Neutral,Neutral,Neutral,0.9855261187925067,0.12067178547819134,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2721,0.8075,-22.2477,-7.55560463861685,0.7931992917968689,Pathogenic,0.8099,pathogenic,-3.981,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E224H,NP_000537:p.Glu224His,,,,,saturation_mutlist,,,,,,,,0.55502,0.05654286146163941,,-0.25875990262771537,,0.1481300486861423,,Neutral,Neutral,,Neutral,0.13699855477356504,,0.06427756862701486,0.35401,,0.21778496154668425,,0.2858974807733421,,Neutral,,Neutral,,0.08236471828403824,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2847,0.8075,-22.2477,-5.85050934729268,0.0829415104625962,Benign,0.9693,pathogenic,-3.684,available,https://doi.org/10.1101/2022.10.22.513328 +E224I,NP_000537:p.Glu224Ile,,,,,saturation_mutlist,,,,,,,,0.60091,0.10179584741592407,,-0.1561905214220279,,0.22235973928898606,,Neutral,Neutral,,Neutral,0.1434041588921694,,0.23564172882224588,0.5294,,0.6808093445345857,,0.6051046722672928,,Neutral,,Neutral,,0.5013608142679996,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2987,0.8075,-22.2477,-6.84410205171627,0.7788767102719698,Pathogenic,0.9465,pathogenic,-4.034,available,https://doi.org/10.1101/2022.10.22.513328 +E224K,NP_000537:p.Glu224Lys,"hg19,17:g.7578179C>T, hg19,17:g.7674861C>T, hg38,17:g.7674861C>T",,,0.701,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480767,Uncertain significance,2,,,,,0.09465,-0.05264605045318602,-0.3345833333333333,-0.054385845158404666,-0.11996666666666664,0.020132077420797666,Neutral,Neutral,Neutral,Neutral,Neutral,0.185232823234117,0.33911028592807707,0.061792661442827614,-0.40487,-0.22959333333333332,0.5395223839174166,-0.3172316666666667,0.06732619195870829,Neutral,Neutral,Neutral,Neutral,0.20529130673806484,0.08672136701639366,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2684,0.8075,-22.2477,-7.15390804138825,0.4346708784164247,Uncertain,0.9057,pathogenic,-3.782,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E224L,NP_000537:p.Glu224Leu,,,,,saturation_mutlist,,,,,,,,0.28587,0.1345692729949951,,-0.35839226724940737,,-0.03626113362470368,,Neutral,Neutral,,Neutral,0.12151285758049668,,0.09136472008509866,-0.00176,,0.22792445688827115,,0.11308222844413557,,Neutral,,Neutral,,0.12786116840423925,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2331,0.8075,-8.9599,-6.84410205171627,0.8124095656545736,Pathogenic,0.9481,pathogenic,-4.059,available,https://doi.org/10.1101/2022.10.22.513328 +E224M,NP_000537:p.Glu224Met,,,,,saturation_mutlist,,,,,,,,0.18366,0.09945784807205199,,-0.02083484178632017,,0.08141257910683991,,Neutral,Neutral,,Neutral,0.1188036394742113,,0.0060456918897850934,-0.38968,,0.4922444243475019,,0.051282212173750924,,Neutral,,Neutral,,0.06076211551145191,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2497,0.8075,-22.2477,-6.84410205171627,0.7459504453004853,Pathogenic,0.9212,pathogenic,-4.004,available,https://doi.org/10.1101/2022.10.22.513328 +E224N,NP_000537:p.Glu224Asn,,,,,saturation_mutlist,,,,,,,,0.33957,0.12967021465301512,,-0.0227924787706074,,0.15838876061469628,,Neutral,Neutral,,Neutral,0.14330498233873315,,0.09209799453772954,-0.09342,,0.4718306319504179,,0.18920531597520895,,Neutral,,Neutral,,0.05527205647547919,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2726,0.8075,-22.2477,-4.53675363892711,0.741931461197856,Pathogenic,0.9447,pathogenic,-3.88,available,https://doi.org/10.1101/2022.10.22.513328 +E224P,NP_000537:p.Glu224Pro,,,,,saturation_mutlist,,,,,,,,-0.7607,-0.05916761875152586,,1.9751050470455056,,0.6072025235227527,,Neutral,Neutral,,Neutral,0.2769686114864099,,0.7036103460605196,0.09956,,3.3347187766957966,,1.7171393883478983,,Uncertain,,Neutral,,1.2418465411780741,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.4034,0.8075,-22.2477,-5.92380369696755,0.0644721519422535,Benign,0.9288,pathogenic,-3.62,available,https://doi.org/10.1101/2022.10.22.513328 +E224Q,NP_000537:p.Glu224Gln,"hg19,17:g.7578179C>G, hg38,17:g.7674861C>G",,,0.533,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.10454,-0.09760813713073731,-0.08526333333333334,0.15512758947502478,0.009638333333333325,0.1298337947375124,Neutral,Neutral,Neutral,Neutral,Neutral,0.12385889038640571,0.18923817274065563,0.04153905583244516,-0.37879,-0.31383333333333335,0.6175611236066748,-0.3463116666666667,0.1193855618033374,Neutral,Neutral,Neutral,Neutral,0.34465569847151645,0.06091875597267759,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.1072,0.8075,-0.3564,-1.91513849442025,1.8540097530009485e-07,Benign,0.4287,ambiguous,-2.94,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E224R,NP_000537:p.Glu224Arg,,,,,saturation_mutlist,,,,,,,,0.13404,0.04982725858688355,,-0.21943645213806592,,-0.042698226069032966,,Neutral,Neutral,,Neutral,0.17020417849538705,,0.048302739729272015,-0.39029,,0.3273033392750581,,-0.031493330362470956,,Neutral,,Neutral,,0.04258897826285917,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2611,0.8075,-8.9599,-4.64231007967343,0.1327728796971731,Benign,0.9148,pathogenic,-3.633,available,https://doi.org/10.1101/2022.10.22.513328 +E224S,NP_000537:p.Glu224Ser,,,,,saturation_mutlist,,,,,,,,0.24026,-0.09790547132492065,,0.20638473944394786,,0.22332236972197395,,Neutral,Neutral,,Neutral,0.1538006622045404,,0.08585939353465416,-0.43809,,0.8039484821067155,,0.18292924105335778,,Neutral,,Neutral,,0.16354730596022887,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2598,0.8075,-22.2477,-5.9935915367348,0.5361025660052672,Uncertain,0.7836,pathogenic,-3.692,available,https://doi.org/10.1101/2022.10.22.513328 +E224T,NP_000537:p.Glu224Thr,,,,,saturation_mutlist,,,,,,,,0.60686,-0.027503774166107168,,0.0883682826705519,,0.3476141413352759,,Neutral,Neutral,,Neutral,0.15382588879431147,,0.054593514593202386,0.36702,,0.7917674926272428,,0.5793937463136214,,Neutral,,Neutral,,0.31709463409945365,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2757,0.8075,-22.2477,-6.51966851149614,0.5220185943782351,Uncertain,0.8748,pathogenic,-3.976,available,https://doi.org/10.1101/2022.10.22.513328 +E224V,NP_000537:p.Glu224Val,"hg19,17:g.7578178T>A, hg38,17:g.7674860T>A",,,0.868,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.71761,0.10803360700607299,0.24773,-0.03855848109713623,0.48267,0.3395257594514319,Neutral,Neutral,Neutral,Neutral,Neutral,0.15979448999749124,0.44010896309891256,0.18862079489263994,0.55567,-0.5470533333333334,0.640061762546143,0.004308333333333303,0.5978658812730715,Neutral,Neutral,Neutral,Neutral,0.4408430156214593,0.4238064721514271,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2596,0.8075,-22.2477,-6.31570379136526,0.3745897440488386,Uncertain,0.82,pathogenic,-3.685,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E224W,NP_000537:p.Glu224Trp,,,,,saturation_mutlist,,,,,,,,0.23569,0.3041585648059845,,-0.43163743891363066,,-0.09797371945681532,,Neutral,Neutral,,Neutral,0.18676002212909792,,0.07575918800623699,0.51501,,0.06220383891317962,,0.2886069194565898,,Neutral,,Neutral,,0.301836364433049,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.3035,0.8075,-22.2477,-6.67883821107086,0.7915920172110541,Pathogenic,0.9972,pathogenic,-4.341,available,https://doi.org/10.1101/2022.10.22.513328 +E224Y,NP_000537:p.Glu224Tyr,,,,,saturation_mutlist,,,,,,,,0.20826,0.22400519013404846,,-0.10475316387711926,,0.05175341806144037,,Neutral,Neutral,,Neutral,0.15712277656785834,,0.05518673334436667,0.46203,,0.32089710355375606,,0.391463551776878,,Neutral,,Neutral,,0.20432525991553593,85.137,13.743,66.195,24.192,,True,85.137,,neutral,neutral,neutral,,True,66.195,,neutral,neutral,neutral,uncertain,,-0.2942,0.8075,-22.2477,-6.67883821107086,0.8391804471259683,Pathogenic,0.99,pathogenic,-4.297,available,https://doi.org/10.1101/2022.10.22.513328 +V225A,NP_000537:p.Val225Ala,"hg19,17:g.7577607A>G, hg38,17:g.7674289A>G",,,0.449,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.02445,-0.204368394613266,-0.17154,0.30299212967868666,-0.073545,0.16372106483934334,Neutral,Neutral,Neutral,Neutral,Neutral,0.06249128583102957,0.08757534927135603,0.06182079689885245,-0.87326,-0.41791333333333336,0.5043981608551176,-0.6455866666666668,-0.18443091957244123,Neutral,Neutral,Neutral,Neutral,0.5271004186638022,0.23652798969755073,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.1915,0.8678,-6.6352,-1.53192676045706,0.0026111250186697,Benign,0.2646,benign,-3.413,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V225C,NP_000537:p.Val225Cys,,,,,saturation_mutlist,,,,,,,,0.0574,-0.3004138720035553,,0.9296372249682457,,0.4935186124841229,,Neutral,Neutral,,Neutral,0.08289425058604795,,0.024852612234678228,-0.49945,,0.9735498030768718,,0.2370499015384359,,Neutral,,Neutral,,0.18837794234311428,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.299,0.8678,-22.2448,-4.71105889068517,0.067453485424971,Benign,0.8601,pathogenic,-4.025,available,https://doi.org/10.1101/2022.10.22.513328 +V225D,NP_000537:p.Val225Asp,"hg19,17:g.7577607A>T, hg38,17:g.7674289A>T",,,0.645,"COSMIC,ClinVar,saturation_mutlist",850916,Conflicting classifications of pathogenicity,1,,,,,0.0207,-0.33230191469192505,-0.40192999999999995,-0.03254857049710826,-0.19061499999999998,-0.005924285248554132,Neutral,Neutral,Neutral,Neutral,Neutral,0.09544266267738283,0.16594169658849056,0.07366898032921362,-0.66693,0.10555666666666663,0.3098790543355686,-0.2806866666666667,-0.1785254728322157,Neutral,Neutral,Neutral,Neutral,0.9426120927272021,0.22150952519537928,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.4378,0.8678,-22.2448,-5.34716918537026,0.0696620439250769,Benign,0.6692,pathogenic,-4.042,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V225E,NP_000537:p.Val225Glu,,,,,saturation_mutlist,,,,,,,,-0.07746,-0.2366922152042389,,-0.11467481866897052,,-0.09606740933448527,,Neutral,Neutral,,Neutral,0.0853254394845968,,0.06698926021692726,-0.5326,,0.27900532936871064,,-0.12679733531564466,,Neutral,,Neutral,,0.313887786252385,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.3951,0.8678,-22.2448,-5.90246190022223,0.7585363892313824,Pathogenic,0.5667,pathogenic,-4.046,available,https://doi.org/10.1101/2022.10.22.513328 +V225F,NP_000537:p.Val225Phe,"hg19,17:g.7577608C>A, hg38,17:g.7674290C>A",,,0.704,"COSMIC,ClinVar,saturation_mutlist",2122381,Uncertain significance,1,,,,,-0.29926,-0.02904110789299011,0.14422,-0.0009841262196671012,-0.07752000000000002,-0.15012206310983356,Neutral,Neutral,Neutral,Neutral,Neutral,0.09114022768354971,0.15793394758569163,0.021984771619647035,-0.86075,-0.8852633333333334,0.19040411829395087,-0.8730066666666667,-0.33517294085302457,Neutral,Neutral,Neutral,Neutral,1.156267792780817,0.22204220251160953,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.3483,0.8678,-22.2448,-5.70657313311416,0.7050680799784068,Pathogenic,0.4754,ambiguous,-4.036,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V225G,NP_000537:p.Val225Gly,"hg38,17:g.7674289A>C",,,0.644,"COSMIC,saturation_mutlist",,,,,,,,0.11387,0.05399834752082823,0.3659866666666667,0.7018366693279399,0.23992833333333335,0.40785333466396995,Neutral,Neutral,Neutral,Neutral,Neutral,0.18863217813221445,0.0993366133686646,0.029805316510770712,-1.61878,-0.05623666666666671,0.766448101797336,-0.8375083333333334,-0.42616594910133204,Neutral,Neutral,Neutral,Neutral,1.6334470386748252,0.18841865144722003,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.397,0.8678,-22.2448,-5.42787583996965,0.3876821167476796,Uncertain,0.4103,ambiguous,-3.935,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V225H,NP_000537:p.Val225His,,,,,saturation_mutlist,,,,,,,,0.05562,-0.0611051285266876,,-0.16790295081866854,,-0.05614147540933427,,Neutral,Neutral,,Neutral,0.06635747438735842,,0.01655438419713387,-0.5884,,0.0047468814871981695,,-0.29182655925640094,,Neutral,,Neutral,,0.19230900509653895,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.4407,0.8678,-22.2448,-5.3819787118312,0.1620136557809015,Benign,0.8768,pathogenic,-4.018,available,https://doi.org/10.1101/2022.10.22.513328 +V225I,NP_000537:p.Val225Ile,"hg19,17:g.7577608C>T, hg38,17:g.7674290C>T",,,0.388,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480736,Conflicting classifications of pathogenicity,1,,,,,-0.11702,-0.015012251138687118,0.12120333333333333,0.07782429730897593,0.0020916666666666653,-0.019597851345512035,Neutral,Neutral,Neutral,Neutral,Neutral,0.023211601928569695,0.03231702784738858,0.009885010295851213,-0.29084,0.015306666666666654,0.4047859189814238,-0.13776666666666668,0.056972959490711905,Neutral,Neutral,Neutral,Neutral,0.24010998165192735,0.43567561263726695,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.1257,0.8678,-6.3721,-0.536556513058598,0.1029328274383572,Benign,0.1204,benign,-3.647,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V225K,NP_000537:p.Val225Lys,,,,,saturation_mutlist,,,,,,,,-0.31262,0.02627580046653745,,0.02653398501759757,,-0.14304300749120122,,Neutral,Neutral,,Neutral,0.09430848898610543,,0.026248705104897706,-1.05618,,0.16033287590501172,,-0.44792356204749406,,Neutral,,Neutral,,0.15811644452902715,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.434,0.8678,-22.2448,-5.86020722634012,0.3558527492771276,Uncertain,0.7211,pathogenic,-4.147,available,https://doi.org/10.1101/2022.10.22.513328 +V225L,NP_000537:p.Val225Leu,,,,,saturation_mutlist,,,,,,,,-0.20108,-0.12479141354560852,-0.10090666666666669,-0.1317262322656176,-0.15099333333333334,-0.1664031161328088,Neutral,Neutral,Neutral,Neutral,Neutral,0.06162099990665709,0.044458386785347435,0.014051065946007388,-0.81045,-0.3526066666666667,-0.06931946653258081,-0.5815283333333333,-0.4398847332662904,Neutral,Neutral,Neutral,Neutral,0.37906150374605735,0.24601714068883138,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.1731,0.8678,-2.9127,-1.65744017387142,7.450277810250941e-08,Benign,0.4183,ambiguous,-3.263,available,https://doi.org/10.1101/2022.10.22.513328 +V225M,NP_000537:p.Val225Met,,,,,saturation_mutlist,,,,,,,,-0.11355,-0.03743059754371641,,0.12299021454648024,,0.004720107273240119,,Neutral,Neutral,,Neutral,0.08969943449756794,,0.0393006368324425,-0.94189,,0.20821004646001684,,-0.3668399767699916,,Neutral,,Neutral,,0.19590708152536648,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.2809,0.8678,-22.2448,-2.10973895472684,0.4640763297575456,Uncertain,0.3587,ambiguous,-3.764,available,https://doi.org/10.1101/2022.10.22.513328 +V225N,NP_000537:p.Val225Asn,,,,,saturation_mutlist,,,,,,,,-0.11783,-0.09183100938796994,,0.11710539541176603,,-0.00036230229411698955,,Neutral,Neutral,,Neutral,0.14458764748174463,,0.016678252059136252,-0.77863,,0.16253137068202436,,-0.3080493146589878,,Neutral,,Neutral,,0.14705330307359094,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.3578,0.8678,-8.957,-2.61885085922721,0.4170886313313269,Uncertain,0.6382,pathogenic,-3.966,available,https://doi.org/10.1101/2022.10.22.513328 +V225P,NP_000537:p.Val225Pro,,,,,saturation_mutlist,,,,,,,,-0.144,-0.2734439408779144,,1.0131222630456984,,0.4345611315228492,,Neutral,Neutral,,Neutral,0.2048600316755568,,0.4707025615343593,0.12145,,1.6725904081442453,,0.8970202040721227,,Neutral,,Neutral,,0.9257318052838913,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.3945,0.8678,-6.3721,-3.47343953537403,0.0004239223875519,Benign,0.5258,ambiguous,-3.448,available,https://doi.org/10.1101/2022.10.22.513328 +V225Q,NP_000537:p.Val225Gln,,,,,saturation_mutlist,,,,,,,,-0.14985,-0.08694785714149472,,0.22981123119101957,,0.03998061559550978,,Neutral,Neutral,,Neutral,0.07725061431857957,,0.006490725608520525,-0.82258,,0.45948274506412967,,-0.18154862746793515,,Neutral,,Neutral,,0.20577891224834954,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.4057,0.8678,-22.2448,-5.90246190022223,0.7553740163047278,Pathogenic,0.6754,pathogenic,-4.044,available,https://doi.org/10.1101/2022.10.22.513328 +V225R,NP_000537:p.Val225Arg,,,,,saturation_mutlist,,,,,,,,-0.30365,0.07256878018379209,,-0.026970573029076933,,-0.16531028651453844,,Neutral,Neutral,,Neutral,0.08400927633033832,,0.006971461718046525,-1.02524,,0.0432057674241578,,-0.49101711628792105,,Neutral,,Neutral,,0.1665362144300003,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.3872,0.8678,-8.957,-4.22105053032847,0.2480025335352462,Benign,0.6581,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +V225S,NP_000537:p.Val225Ser,,,,,saturation_mutlist,,,,,,,,0.01432,-0.1526912438869476,,0.159260625776282,,0.086790312888141,,Neutral,Neutral,,Neutral,0.08327082217141211,,0.08678631076568726,-0.7564,,0.4352639385314381,,-0.16056803073428094,,Neutral,,Neutral,,0.23101054233454496,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.3748,0.8678,-22.2448,-4.12317779642017,0.0036450640012343,Benign,0.538,ambiguous,-3.722,available,https://doi.org/10.1101/2022.10.22.513328 +V225T,NP_000537:p.Val225Thr,,,,,saturation_mutlist,,,,,,,,0.02588,-0.03040120005607604,,0.18024134783906096,,0.10306067391953047,,Neutral,Neutral,,Neutral,0.09618305286068556,,0.0371881928322199,-0.32129,,0.4855059406438573,,0.08210797032192865,,Neutral,,Neutral,,0.32590978182235397,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.2902,0.8678,-22.2448,-4.12789470862988,0.0298198797391941,Benign,0.3814,ambiguous,-3.638,available,https://doi.org/10.1101/2022.10.22.513328 +V225W,NP_000537:p.Val225Trp,,,,,saturation_mutlist,,,,,,,,-0.08618,-0.08094824910163878,,-0.30158708668452844,,-0.1938835433422642,,Neutral,Neutral,,Neutral,0.09753644112395654,,0.04907053565492209,-0.54525,,-0.04834765651514269,,-0.29679882825757137,,Neutral,,Neutral,,0.31913111355451346,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.3889,0.8678,-22.2448,-5.70657313311416,0.7350077310600601,Pathogenic,0.9312,pathogenic,-4.417,available,https://doi.org/10.1101/2022.10.22.513328 +V225Y,NP_000537:p.Val225Tyr,,,,,saturation_mutlist,,,,,,,,-0.28098,0.01366206526756283,,0.0320326405966205,,-0.12447367970168975,,Neutral,Neutral,,Neutral,0.09719647549043377,,0.028304678775537644,-0.68352,,0.23722254718813487,,-0.22314872640593258,,Neutral,,Neutral,,0.24335743861348677,128.068,12.487,78.92,20.332,,True,128.068,,neutral,neutral,neutral,,True,78.92,,neutral,neutral,neutral,uncertain,,-0.3918,0.8678,-22.2448,-5.70657313311416,0.8049462602084301,Pathogenic,0.8257,pathogenic,-4.17,available,https://doi.org/10.1101/2022.10.22.513328 +G226A,NP_000537:p.Gly226Ala,"hg19,17:g.7577604C>G, hg38,17:g.7674286C>G",,,0.767,"COSMIC,ClinVar,saturation_mutlist",951459,Uncertain significance,2,,,,,2.92462,0.9268728423118592,2.6677999999999997,1.8013082159587792,2.79621,2.3629641079793897,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.13744215949510713,1.3211925191280791,0.3513291549910061,1.74161,1.05,0.9482603713503664,1.3958050000000002,1.3449351856751832,Neutral,Neutral,Neutral,Neutral,0.573390608631382,0.8228827622770923,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.3023,0.1477,-8.9511,-2.4820308572667,0.4283098310503548,Uncertain,0.7389,pathogenic,-3.864,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G226C,NP_000537:p.Gly226Cys,"hg38,17:g.7674287C>A",,,0.877,"COSMIC,saturation_mutlist",,,,,,,,3.03683,0.5478535532951355,,2.116911213712193,,2.5768706068560965,,Uncertain,Neutral,,Uncertain,0.05870453030719754,,0.3442816947902143,2.23481,,1.4883307151311822,,1.861570357565591,,Uncertain,,Neutral,,0.6611738610002503,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.4298,0.1477,-22.239,-6.34851394065188,0.7837776573565471,Pathogenic,0.8709,pathogenic,-4.245,available,https://doi.org/10.1101/2022.10.22.513328 +G226D,NP_000537:p.Gly226Asp,"hg19,17:g.7577604C>T, hg38,17:g.7674286C>T",,,0.698,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,3.11229,0.9542156982421875,1.8124700000000002,1.0845764659327586,2.46238,2.098433232966379,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.08272713299376552,1.3850143560988817,0.2857668940364066,2.05081,0.85306,0.5451748055258209,1.451935,1.2979924027629104,Uncertain,Uncertain,Neutral,Neutral,0.7483351896487741,0.5723824600536869,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.3523,0.1477,-6.9513,-2.41477542882087,0.320013766783454,Benign,0.8313,pathogenic,-3.982,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G226E,NP_000537:p.Gly226Glu,,,,,saturation_mutlist,,,,,,,,3.31883,0.9637524652481079,,1.4387494395860356,,2.378789719793018,,Uncertain,Neutral,,Uncertain,0.07040718124731202,,0.2863102228871226,1.98555,,0.7586699816726584,,1.3721099908363292,,Neutral,,Neutral,,0.7578197660022418,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.3619,0.1477,-8.9511,-2.40860232352943,0.4628142345976547,Uncertain,0.921,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328 +G226F,NP_000537:p.Gly226Phe,,,,,saturation_mutlist,,,,,,,,3.09545,1.0284362173080444,,1.3333349774221617,,2.2143924887110806,,Uncertain,Uncertain,,Uncertain,0.11672923741871225,,0.3530652090436683,1.8414,,0.6875155399216637,,1.2644577699608317,,Neutral,,Neutral,,0.6905690888363463,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.4679,0.1477,-22.239,-7.34453480461727,0.8627807594418364,Pathogenic,0.9651,pathogenic,-4.573,available,https://doi.org/10.1101/2022.10.22.513328 +G226H,NP_000537:p.Gly226His,,,,,saturation_mutlist,,,,,,,,3.33632,0.9025420498847961,,1.0022109577421408,,2.1692654788710706,,Uncertain,Neutral,,Uncertain,0.07626270361304846,,0.339551292257124,1.97884,,0.42659633452292756,,1.2027181672614637,,Neutral,,Neutral,,0.6349613224855045,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.4427,0.1477,-22.239,-7.34453480461727,0.8444038723266388,Pathogenic,0.9737,pathogenic,-4.391,available,https://doi.org/10.1101/2022.10.22.513328 +G226I,NP_000537:p.Gly226Ile,,,,,saturation_mutlist,,,,,,,,4.71601,1.4005568790435792,,2.922333562083496,,3.8191717810417476,,Uncertain,Uncertain,,Destabilizing,0.2155153639531342,,0.4231467556119806,3.03764,,1.8193723689050554,,2.4285061844525275,,Uncertain,,Uncertain,,1.4722995317361645,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.5136,0.1477,-22.239,-7.59947433762722,0.8639690646442839,Pathogenic,0.9627,pathogenic,-4.538,available,https://doi.org/10.1101/2022.10.22.513328 +G226K,NP_000537:p.Gly226Lys,,,,,saturation_mutlist,,,,,,,,3.04503,1.0808675026893615,,1.1299540128643561,,2.087492006432178,,Uncertain,Uncertain,,Uncertain,0.11790513544384462,,0.41050112708023695,1.74399,,0.5577665610918373,,1.1508782805459186,,Neutral,,Neutral,,0.6357103765512628,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.4626,0.1477,-22.239,-7.59947433762722,0.8659414183133936,Pathogenic,0.9898,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +G226L,NP_000537:p.Gly226Leu,,,,,saturation_mutlist,,,,,,,,3.32365,1.0603766965866088,,1.3947911588675959,,2.359220579433798,,Uncertain,Uncertain,,Uncertain,0.11758276873295662,,0.34123921729017864,1.79545,,0.597630445673981,,1.1965402228369906,,Neutral,,Neutral,,0.8066900946498299,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.4818,0.1477,-22.239,-7.59947433762722,0.8608623076180737,Pathogenic,0.9563,pathogenic,-4.516,available,https://doi.org/10.1101/2022.10.22.513328 +G226M,NP_000537:p.Gly226Met,,,,,saturation_mutlist,,,,,,,,3.25264,1.0282378888130188,,1.4619352431741548,,2.3572876215870773,,Uncertain,Uncertain,,Uncertain,0.09980246885130079,,0.31029894540666275,1.99605,,0.8066216075468734,,1.4013358037734367,,Neutral,,Neutral,,0.7420759902474129,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.42,0.1477,-22.239,-7.59947433762722,0.856335066399476,Pathogenic,0.9771,pathogenic,-4.496,available,https://doi.org/10.1101/2022.10.22.513328 +G226N,NP_000537:p.Gly226Asn,,,,,saturation_mutlist,,,,,,,,2.8208,0.7833315801620483,,0.858468389890219,,1.8396341949451096,,Uncertain,Neutral,,Neutral,0.07955211783384891,,0.33774552296319355,1.83821,,0.3392867525799486,,1.0887483762899743,,Neutral,,Neutral,,0.41864716207938385,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.4307,0.1477,-22.239,-6.34851394065188,0.8511342835267011,Pathogenic,0.9234,pathogenic,-4.269,available,https://doi.org/10.1101/2022.10.22.513328 +G226P,NP_000537:p.Gly226Pro,,,,,saturation_mutlist,,,,,,,,6.78988,1.4006974267959595,,6.922865071860678,,6.856372535930339,,Destabilizing,Uncertain,,Destabilizing,0.18908826704368792,,0.7946129729325153,4.42747,,5.188209117101256,,4.8078395585506275,,Destabilizing,,Destabilizing,,2.5369305354053377,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.5277,0.1477,-22.239,-7.59947433762722,0.8703754082036055,Pathogenic,0.9802,pathogenic,-4.315,available,https://doi.org/10.1101/2022.10.22.513328 +G226Q,NP_000537:p.Gly226Gln,,,,,saturation_mutlist,,,,,,,,3.16567,1.0898962306976319,,1.4895723604049307,,2.327621180202465,,Uncertain,Uncertain,,Uncertain,0.09092309585002147,,0.3955587699262564,1.65283,,0.8941241821662481,,1.2734770910831241,,Neutral,,Neutral,,0.6821999505721607,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.4336,0.1477,-22.239,-5.68301129149202,0.5488300912519878,Uncertain,0.9641,pathogenic,-4.158,available,https://doi.org/10.1101/2022.10.22.513328 +G226R,NP_000537:p.Gly226Arg,,,,,"COSMIC,saturation_mutlist",,,,,,,,2.96232,1.0393059849739075,,1.0621598847604832,,2.0122399423802415,,Uncertain,Uncertain,,Uncertain,0.10911623498008717,,0.4370714827765058,1.80475,,0.4371835779466222,,1.1209667889733113,,Neutral,,Neutral,,0.6543375188194296,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.4466,0.1477,-22.239,-7.59947433762722,0.764258778073929,Pathogenic,0.9674,pathogenic,-4.172,available,https://doi.org/10.1101/2022.10.22.513328 +G226S,NP_000537:p.Gly226Ser,"hg19,17:g.7577605C>T, hg38,17:g.7674287C>T",,,0.866,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",648028,Uncertain significance,2,,,,,3.38569,0.9962570118904114,1.2980733333333332,1.6667285177495732,2.3418816666666666,2.5262092588747866,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.13089341515272873,0.15945326427793466,0.32632213362693285,2.12612,0.42483000000000004,0.8999547794817798,1.275475,1.5130373897408897,Uncertain,Uncertain,Neutral,Neutral,0.4743233564422763,0.7532750378328223,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.3031,0.1477,-7.9512,-3.82207883968178,0.0915108755976376,Benign,0.6868,pathogenic,-3.618,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G226T,NP_000537:p.Gly226Thr,,,,,saturation_mutlist,,,,,,,,4.04374,1.2117140078544617,,2.4539872795663364,,3.248863639783168,,Uncertain,Uncertain,,Destabilizing,0.1853215994901937,,0.42539577664032074,2.82357,,1.4831741172930564,,2.153372058646528,,Uncertain,,Uncertain,,1.1399025918763175,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.4529,0.1477,-22.239,-6.34851394065188,0.864340875913082,Pathogenic,0.8934,pathogenic,-4.276,available,https://doi.org/10.1101/2022.10.22.513328 +G226V,NP_000537:p.Gly226Val,"hg19,17:g.7577604C>A, hg38,17:g.7674286C>A",,,0.838,"COSMIC,ClinVar,saturation_mutlist",458556,Conflicting classifications of pathogenicity,1,,,,,4.71007,1.3530880117416382,5.301586666666666,2.7124451903377387,5.0058283333333335,3.7112575951688695,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.19761455955442161,0.271301626280091,0.4233285462866953,3.12531,3.6180266666666667,1.6567677156429779,3.371668333333333,2.391038857821489,Destabilizing,Uncertain,Destabilizing,Uncertain,2.417449697626727,1.335942922883986,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.4569,0.1477,-22.239,-7.59947433762722,0.8515373455916199,Pathogenic,0.9277,pathogenic,-4.433,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G226W,NP_000537:p.Gly226Trp,,,,,saturation_mutlist,,,,,,,,3.47251,1.1193663024902343,,1.2322551905554793,,2.3523825952777395,,Uncertain,Uncertain,,Uncertain,0.13408513276354936,,0.30482337837052853,2.15699,,0.4306797248871206,,1.2938348624435603,,Uncertain,,Neutral,,0.7993007604103665,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.4677,0.1477,-22.239,-7.34453480461727,0.8640085379666791,Pathogenic,0.9538,pathogenic,-4.568,available,https://doi.org/10.1101/2022.10.22.513328 +G226Y,NP_000537:p.Gly226Tyr,,,,,saturation_mutlist,,,,,,,,3.20426,1.0317900729179383,,1.4111286152259808,,2.3076943076129903,,Uncertain,Uncertain,,Uncertain,0.09990194416268446,,0.3925812686809207,1.86833,,0.7463068941469387,,1.3073184470734693,,Neutral,,Neutral,,0.718442982104652,77.668,27.784,109.17,22.077,,True,77.668,,neutral,neutral,neutral,,True,109.17,,neutral,neutral,neutral,uncertain,,-0.4683,0.1477,-22.239,-7.34453480461727,0.8235173554497044,Pathogenic,0.9577,pathogenic,-4.548,available,https://doi.org/10.1101/2022.10.22.513328 +S227A,NP_000537:p.Ser227Ala,,,,,saturation_mutlist,,,,,,,,0.01514,-0.05024386644363402,,0.06993970707251514,,0.04253985353625757,,Neutral,Neutral,,Neutral,0.1039847431398634,,0.16220231864750478,0.13886,,0.2542771786001106,,0.19656858930005533,,Neutral,,Neutral,,0.3371971304268432,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,uncertain,,-0.0681,1.345,-4.8638,-0.805629688252832,6.614483750537567e-05,Benign,0.0991,benign,-3.146,available,https://doi.org/10.1101/2022.10.22.513328 +S227C,NP_000537:p.Ser227Cys,,,,,saturation_mutlist,,,,,,,,0.0182,-0.13683973312377928,0.5682566666666666,0.6767439098855897,0.2932283333333333,0.34747195494279487,Neutral,Neutral,Neutral,Neutral,Neutral,0.1796663616964139,0.3493242843293638,0.11713019358021363,0.37144,0.47483000000000003,0.7359644241939757,0.42313500000000004,0.5537022120969879,Neutral,Neutral,Neutral,Neutral,0.39845912387596294,0.32048728907282414,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.1292,1.345,-6.9513,-1.01244842519811,3.81532446597354e-06,Benign,0.1364,benign,-3.21,available,https://doi.org/10.1101/2022.10.22.513328 +S227D,NP_000537:p.Ser227Asp,,,,,saturation_mutlist,,,,,,,,0.54839,0.20982183933258056,,0.28536878785038855,,0.4168793939251943,,Neutral,Neutral,,Neutral,0.3245675807076256,,0.14505416314510647,0.68767,,0.17007829566555185,,0.42887414783277594,,Neutral,,Neutral,,0.13947154133654951,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.2554,1.345,-22.239,-5.09404086805612,0.2450659360866122,Benign,0.8405,pathogenic,-3.865,available,https://doi.org/10.1101/2022.10.22.513328 +S227E,NP_000537:p.Ser227Glu,,,,,saturation_mutlist,,,,,,,,0.33654,0.0073919415473938386,,0.11310950016780247,,0.22482475008390124,,Neutral,Neutral,,Neutral,0.3396130929148176,,0.13201419987728327,0.64138,,0.33374488304118527,,0.4875624415205926,,Neutral,,Neutral,,0.19101542975829375,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.2286,1.345,-22.239,-5.1589504096365,0.1648821851491781,Benign,0.8379,pathogenic,-3.732,available,https://doi.org/10.1101/2022.10.22.513328 +S227F,NP_000537:p.Ser227Phe,"hg19,17:g.7577601G>A, hg38,17:g.7674283G>A",,,0.727,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3634429,Uncertain significance,1,,,,,-0.04623,0.13771724939346314,0.2612233333333333,-0.3933259378292688,0.10749666666666666,-0.2197779689146344,Neutral,Neutral,Neutral,Neutral,Neutral,0.2789658519893187,0.9009168629173775,0.3343588908600937,0.48367,-0.11723333333333334,-0.12524766675100443,0.18321833333333332,0.17921116662449776,Neutral,Neutral,Neutral,Neutral,0.3442676631472798,0.23315353037150097,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.2348,1.345,-22.239,-6.80108941624029,0.5169494030222255,Uncertain,0.548,ambiguous,-4.088,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S227G,NP_000537:p.Ser227Gly,,,,,saturation_mutlist,,,,,,,,0.4367,0.2850284194946289,,0.7800524154039081,,0.6083762077019541,,Neutral,Neutral,,Neutral,0.11087419826913995,,0.160083023809677,-0.82399,,0.6471051074470046,,-0.08844244627649772,,Neutral,,Neutral,,0.08161185213538855,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,uncertain,,-0.1659,1.345,-22.239,-6.80108941624029,0.1603026045290813,Benign,0.2313,benign,-3.619,available,https://doi.org/10.1101/2022.10.22.513328 +S227H,NP_000537:p.Ser227His,,,,,saturation_mutlist,,,,,,,,0.59573,0.012154536247253432,,-0.3359679358861132,,0.1298810320569434,,Neutral,Neutral,,Neutral,0.23203124906910177,,0.18791016446114497,0.98343,,-0.19117031840178397,,0.396129840799108,,Neutral,,Neutral,,0.1943610377084103,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.236,1.345,-22.239,-6.80108941624029,0.7210515835217852,Pathogenic,0.8233,pathogenic,-3.961,available,https://doi.org/10.1101/2022.10.22.513328 +S227I,NP_000537:p.Ser227Ile,,,,,saturation_mutlist,,,,,,,,0.43545,0.09994863986968994,,-0.15054251321290216,,0.14245374339354894,,Neutral,Neutral,,Neutral,0.3304588345346126,,0.20696650997443355,1.80398,,0.21905023617363598,,1.011515118086818,,Neutral,,Neutral,,0.4325702048713159,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.2379,1.345,-22.239,-5.04149545590972,0.6958010218157198,Pathogenic,0.6695,pathogenic,-3.912,available,https://doi.org/10.1101/2022.10.22.513328 +S227K,NP_000537:p.Ser227Lys,,,,,saturation_mutlist,,,,,,,,-0.25807,0.004873341321945206,,-0.01579702669085284,,-0.13693351334542642,,Neutral,Neutral,,Neutral,0.22332704176408685,,0.1831927422775729,0.06713,,0.23590389230008876,,0.15151694615004438,,Neutral,,Neutral,,0.24499191282024546,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.2453,1.345,-22.239,-5.94438103249811,0.3232824927551385,Uncertain,0.9701,pathogenic,-3.827,available,https://doi.org/10.1101/2022.10.22.513328 +S227L,NP_000537:p.Ser227Leu,,,,,saturation_mutlist,,,,,,,,-0.20403,0.025325803756713863,,-0.5909122866179227,,-0.3974711433089614,,Neutral,Neutral,,Neutral,0.30877264270230903,,0.20674905152698486,0.48052,,-0.42748699202189894,,0.026516503989050533,,Neutral,,Neutral,,0.30035314667366136,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.1583,1.345,-7.3663,-3.58515710816714,0.0633611642811143,Benign,0.2155,benign,-3.596,available,https://doi.org/10.1101/2022.10.22.513328 +S227M,NP_000537:p.Ser227Met,,,,,saturation_mutlist,,,,,,,,-0.38084,-0.018190312385559078,,-0.20952792984967106,,-0.29518396492483556,,Neutral,Neutral,,Neutral,0.22904191956157788,,0.18995692347358273,0.27878,,-0.1011379814579577,,0.08882100927102113,,Neutral,,Neutral,,0.35130133669608826,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.1293,1.345,-7.3663,-3.63745873597621,0.0008267247925185,Benign,0.3528,ambiguous,-3.417,available,https://doi.org/10.1101/2022.10.22.513328 +S227N,NP_000537:p.Ser227Asn,,,,,saturation_mutlist,,,,,,,,0.21945,0.07782858610153198,,0.011214204729098093,,0.11533210236454905,,Neutral,Neutral,,Neutral,0.22665730689762878,,0.14835890008728128,0.32018,,-0.2008633782137803,,0.059658310893109856,,Neutral,,Neutral,,0.14681381257681003,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.179,1.345,-22.239,-5.11015122727727,0.1345326634030338,Benign,0.6008,pathogenic,-3.541,available,https://doi.org/10.1101/2022.10.22.513328 +S227P,NP_000537:p.Ser227Pro,"hg19,17:g.7577602A>G, hg38,17:g.7674284A>G",,,0.681,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,3.1197,1.093585605621338,6.046033333333334,2.4340930467392528,4.582866666666667,2.7768965233696266,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,0.22396581758277712,1.9117621467350194,0.6694546069459401,2.9203,2.6725599999999994,3.4869880504945585,2.79643,3.2036440252472795,Uncertain,Uncertain,Uncertain,Destabilizing,2.7623176441652517,0.4813393161497599,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.2424,1.345,-8.9511,-6.22351859774356,0.355718710316241,Uncertain,0.9492,pathogenic,-3.754,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S227Q,NP_000537:p.Ser227Gln,,,,,saturation_mutlist,,,,,,,,-0.00084,-0.1023824644088745,,0.14531289950966256,,0.07223644975483128,,Neutral,Neutral,,Neutral,0.23459387969228843,,0.21511006633192475,0.31058,,0.32341849456208577,,0.3169992472810429,,Neutral,,Neutral,,0.21921491788545222,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.1987,1.345,-22.239,-5.00815519311386,0.0689674953125924,Benign,0.8402,pathogenic,-3.577,available,https://doi.org/10.1101/2022.10.22.513328 +S227R,NP_000537:p.Ser227Arg,,,,,saturation_mutlist,,,,,,,,-0.41707,0.031335482597351076,,-0.4175563768575981,,-0.41731318842879905,,Neutral,Neutral,,Neutral,0.2260875801327387,,0.24993624114527732,0.1853,,-0.06148612110723354,,0.06190693944638323,,Neutral,,Neutral,,0.11973877465614655,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.2506,1.345,-22.239,-5.128498872062,0.4838141642636629,Uncertain,0.9478,pathogenic,-3.827,available,https://doi.org/10.1101/2022.10.22.513328 +S227T,NP_000537:p.Ser227Thr,,,,,saturation_mutlist,,,,,,,,0.4469,-0.05048745632171629,-0.07970666666666666,0.11774035147000812,0.18359666666666669,0.28232017573500406,Neutral,Neutral,Neutral,Neutral,Neutral,0.20431902204249963,0.11792427212222069,0.14272866574806814,1.1814,-0.5058966666666667,0.5042744674800278,0.3377516666666667,0.8428372337400138,Neutral,Neutral,Neutral,Neutral,0.10328100868773286,0.32850717597510254,39.637,10.986,52.57,32.17,,True,39.637,,neutral,,,,True,52.57,,neutral,,,neutral,,-0.0379,1.345,-0.7714,-1.99749882559897,5.062022763145958e-06,Benign,0.1425,benign,-3.09,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S227V,NP_000537:p.Ser227Val,,,,,saturation_mutlist,,,,,,,,0.59678,0.04052519083023069,,-0.014989584048598995,,0.2908952079757005,,Neutral,Neutral,,Neutral,0.3228209765122803,,0.19993720693544292,1.5435,,0.2912522377452152,,0.9173761188726076,,Neutral,,Neutral,,0.5047190248457212,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.1393,1.345,-7.9512,-3.20135293169315,0.0123084491376646,Benign,0.4741,ambiguous,-3.446,available,https://doi.org/10.1101/2022.10.22.513328 +S227W,NP_000537:p.Ser227Trp,,,,,saturation_mutlist,,,,,,,,0.22447,0.22057467341423034,,-0.7626399086301355,,-0.26908495431506774,,Neutral,Neutral,,Neutral,0.25413752937694734,,0.3584538168744883,1.0382,,-0.3707120726782513,,0.33374396366087433,,Neutral,,Neutral,,0.3519790182509882,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.2445,1.345,-22.239,-6.80108941624029,0.7220692719177828,Pathogenic,0.6894,pathogenic,-4.29,available,https://doi.org/10.1101/2022.10.22.513328 +S227Y,NP_000537:p.Ser227Tyr,"hg38,17:g.7674283G>T",,,0.772,"COSMIC,saturation_mutlist",,,,,,,,0.00457,0.2009667694568634,0.15816,-0.32901479826831875,0.08136499999999999,-0.16222239913415937,Neutral,Neutral,Neutral,Neutral,Neutral,0.28592121005688864,0.9153145936052077,0.3149614369530878,0.43674,-0.16712000000000002,0.012136706199127703,0.13480999999999999,0.22443835309956386,Neutral,Neutral,Neutral,Neutral,0.2318351881545739,0.2096859527531565,39.637,10.986,52.57,32.17,,True,39.637,,uncertain,,,,True,52.57,,uncertain,,,neutral,,-0.2396,1.345,-22.239,-6.80108941624029,0.6497256359529086,Uncertain,0.5655,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228A,NP_000537:p.Asp228Ala,"hg38,17:g.7674280T>G",,,0.758,"COSMIC,saturation_mutlist",,,,,,,,0.04824,0.13746840357780454,0.3165533333333333,0.4839831486607406,0.18239666666666665,0.2661115743303703,Neutral,Neutral,Neutral,Neutral,Neutral,0.18840852038176714,0.1971012163556808,0.14962839206601228,-0.13372,0.05453333333333332,0.4164892358402466,-0.03959333333333334,0.1413846179201233,Neutral,Neutral,Neutral,Neutral,0.161610503852799,0.07359638641299873,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.176,1.011,-6.6293,-3.7265271431836,0.0001063103091481,Benign,0.1645,benign,-3.388,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228C,NP_000537:p.Asp228Cys,,,,,saturation_mutlist,,,,,,,,0.03942,-0.04009047746658325,,1.0454586368669618,,0.5424393184334809,,Neutral,Neutral,,Neutral,0.2553873717355999,,0.17000560484996396,0.01421,,0.9041817113259351,,0.4591958556629675,,Neutral,,Neutral,,0.13283480367115982,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.2971,1.011,-22.239,-5.67654552150741,0.4215506801883402,Uncertain,0.5232,ambiguous,-4.036,available,https://doi.org/10.1101/2022.10.22.513328 +D228E,NP_000537:p.Asp228Glu,"hg19,17:g.7577597G>C, hg19,17:g.7577597G>T, hg19,17:g.7674279G>C, hg38,17:g.7674279G>C, hg38,17:g.7674279G>T",,,"0.370, 0.371","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","954848, 926556","Uncertain significance, Conflicting classifications of pathogenicity","1, 1",,,,,-0.43192,0.23821860551834106,-0.2011333333333333,0.1717414586001866,-0.3165266666666667,-0.13008927069990672,Neutral,Neutral,Neutral,Neutral,Neutral,0.13412829387400102,0.1634896270579744,0.19625407906206432,0.01077,0.06269999999999999,0.1505080599095443,0.036735,0.08063902995477215,Neutral,Neutral,Neutral,Neutral,0.1641548356481364,0.07582878457316242,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.0891,1.011,-0.3967,-0.386789767388704,3.16387615778233e-08,Benign,0.1188,benign,-2.846,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228F,NP_000537:p.Asp228Phe,,,,,saturation_mutlist,,,,,,,,-0.17124,0.3433139932155609,,0.21267128756522827,,0.020715643782614132,,Neutral,Neutral,,Neutral,0.3131245681207755,,0.0830070996027603,-0.2638,,0.06391576172475356,,-0.09994211913762321,,Neutral,,Neutral,,0.07515150911407315,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.3558,1.011,-22.239,-5.58592152223596,0.1359111735954219,Benign,0.595,pathogenic,-4.01,available,https://doi.org/10.1101/2022.10.22.513328 +D228G,NP_000537:p.Asp228Gly,"hg38,17:g.7674280T>C",,,0.704,"COSMIC,saturation_mutlist",,,,,,,,0.32335,0.4005157291889191,0.9344666666666667,0.8166579126914391,0.6289083333333334,0.5700039563457195,Neutral,Neutral,Neutral,Neutral,Neutral,0.28202555071912505,0.16211556152599566,0.2302556165109882,-0.90023,0.5343566666666667,0.7498414886829811,-0.18293666666666664,-0.07519425565850946,Neutral,Neutral,Neutral,Neutral,0.2583954984558017,0.3768606649796822,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.1872,1.011,-6.6293,-3.623202403396,0.0002047575792239,Benign,0.1774,benign,-3.453,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228H,NP_000537:p.Asp228His,"hg19,17:g.7577599C>G, hg38,17:g.7674281C>G",,,0.777,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.06487,0.2242078447341919,-0.21179333333333336,0.04843852020738637,-0.07346166666666668,0.056654260103693184,Neutral,Neutral,Neutral,Neutral,Neutral,0.3169141491453152,0.29272380911402174,0.1364497661172144,0.06514,-0.2797033333333333,-0.06888089576406477,-0.10728166666666665,-0.001870447882032382,Neutral,Neutral,Neutral,Neutral,0.3509317853309323,0.05810068841117248,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.265,1.011,-22.239,-6.0681896198295,0.1972400103681589,Benign,0.2979,benign,-3.758,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228I,NP_000537:p.Asp228Ile,,,,,saturation_mutlist,,,,,,,,-0.10201,0.32410991728305816,,0.44344381960956336,,0.17071690980478169,,Neutral,Neutral,,Neutral,0.27453801061851135,,0.08095935022793471,0.68562,,0.5363629806972554,,0.6109914903486278,,Neutral,,Neutral,,0.4178703828412033,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.348,1.011,-22.239,-6.12964452449616,0.3635848832643872,Uncertain,0.3822,ambiguous,-3.947,available,https://doi.org/10.1101/2022.10.22.513328 +D228K,NP_000537:p.Asp228Lys,,,,,saturation_mutlist,,,,,,,,-0.51927,0.3069430184364319,,0.26493058846879064,,-0.12716970576560468,,Neutral,Neutral,,Neutral,0.3643140685524308,,0.15345016973253378,-0.19316,,0.0857404984993169,,-0.053709750750341546,,Neutral,,Neutral,,0.15491963430855726,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.2586,1.011,-8.9511,-4.2170016269923,0.0016744894807784,Benign,0.3821,ambiguous,-3.604,available,https://doi.org/10.1101/2022.10.22.513328 +D228L,NP_000537:p.Asp228Leu,,,,,saturation_mutlist,,,,,,,,-0.45208,0.23912202835083007,,0.0041568756726349425,,-0.22396156216368251,,Neutral,Neutral,,Neutral,0.2650966772810407,,0.12014203703419339,-0.08457,,-0.11964821878522656,,-0.10210910939261328,,Neutral,,Neutral,,0.10264418237989886,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.2688,1.011,-7.9512,-3.79169604443584,0.0002510157559784,Benign,0.3685,ambiguous,-3.578,available,https://doi.org/10.1101/2022.10.22.513328 +D228M,NP_000537:p.Asp228Met,,,,,saturation_mutlist,,,,,,,,-0.39139,0.30994750022888184,,0.32287578618956425,,-0.03425710690521788,,Neutral,Neutral,,Neutral,0.28007321433754195,,0.11007524386708585,-0.04438,,0.20696247928742506,,0.08129123964371253,,Neutral,,Neutral,,0.0707320202154503,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.2804,1.011,-22.239,-6.12964452449616,0.3249010820710045,Uncertain,0.5882,pathogenic,-4.029,available,https://doi.org/10.1101/2022.10.22.513328 +D228N,NP_000537:p.Asp228Asn,"hg19,17:g.7577599C>T, hg19,17:g.7674281C>T, hg38,17:g.7674281C>T",,,0.546,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1395667,Uncertain significance,2,,,,,-0.06245,0.15417876839637756,-0.12097333333333334,0.1520978949161,-0.09171166666666666,0.044823947458050004,Neutral,Neutral,Neutral,Neutral,Neutral,0.2723944241638333,0.17723580419567853,0.1782409602792348,-0.08755,-0.42347,-0.047160044222976184,-0.25551,-0.0673550221114881,Neutral,Neutral,Neutral,Neutral,0.0963346379381096,0.25868724095660195,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.2224,1.011,-22.239,-3.63637678595156,0.0094055721676452,Benign,0.1058,benign,-3.574,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228P,NP_000537:p.Asp228Pro,,,,,saturation_mutlist,,,,,,,,-0.01732,0.4073789191246033,,1.220848921462577,,0.6017644607312885,,Neutral,Neutral,,Neutral,0.3521569161230512,,0.20875619730348166,1.87529,,3.3465825401319425,,2.610936270065971,,Uncertain,,Uncertain,,1.463087188724599,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.3926,1.011,-22.239,-6.1765366523254,0.0182640026734036,Benign,0.521,ambiguous,-3.825,available,https://doi.org/10.1101/2022.10.22.513328 +D228Q,NP_000537:p.Asp228Gln,,,,,saturation_mutlist,,,,,,,,-0.31513,0.21371552109718323,,0.47278708607124936,,0.07882854303562467,,Neutral,Neutral,,Neutral,0.27294357348903137,,0.1201602790245899,-0.12794,,0.3783731932630346,,0.1252165966315173,,Neutral,,Neutral,,0.09648851906150661,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.2148,1.011,-8.9511,-1.94650618887419,0.0005556825151301,Benign,0.2977,benign,-3.441,available,https://doi.org/10.1101/2022.10.22.513328 +D228R,NP_000537:p.Asp228Arg,,,,,saturation_mutlist,,,,,,,,-0.45744,0.36168933868408204,,0.1820444312874606,,-0.13769778435626973,,Neutral,Neutral,,Neutral,0.3701989999464294,,0.09099186722436824,-0.19113,,0.0321178242233341,,-0.07950608788833295,,Neutral,,Neutral,,0.15792158970103917,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.3574,1.011,-22.239,-5.53340521485805,0.0733103979600607,Benign,0.3934,ambiguous,-3.782,available,https://doi.org/10.1101/2022.10.22.513328 +D228S,NP_000537:p.Asp228Ser,,,,,saturation_mutlist,,,,,,,,0.14213,0.05638920187950133,,0.3138216635859556,,0.2279758317929778,,Neutral,Neutral,,Neutral,0.19041191154137838,,0.1993607781689017,0.01716,,0.3456466658468645,,0.18140333292343225,,Neutral,,Neutral,,0.05818454689314235,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.2621,1.011,-22.239,-4.69043179375549,0.0858854092707639,Benign,0.1199,benign,-3.573,available,https://doi.org/10.1101/2022.10.22.513328 +D228T,NP_000537:p.Asp228Thr,,,,,saturation_mutlist,,,,,,,,0.27769,0.19933535456657409,,0.4091910106348727,,0.3434405053174363,,Neutral,Neutral,,Neutral,0.2710243391263209,,0.13051788155558716,0.49613,,0.5649432232412869,,0.5305366116206435,,Neutral,,Neutral,,0.30311393936315023,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.2243,1.011,-8.9511,-4.99354423711014,0.003621983495045,Benign,0.2187,benign,-3.628,available,https://doi.org/10.1101/2022.10.22.513328 +D228V,NP_000537:p.Asp228Val,"hg38,17:g.7674280T>A",,,0.829,"COSMIC,saturation_mutlist",,,,,,,,0.05468,0.347109227180481,-0.24036333333333335,0.5039270417195134,-0.09284166666666667,0.2793035208597567,Neutral,Neutral,Neutral,Neutral,Neutral,0.2738198542374465,0.14866738587269984,0.04496685316713975,0.59433,1.8275500000000002,0.5555922579823606,1.2109400000000001,0.5749611289911802,Neutral,Neutral,Neutral,Neutral,1.6932285182061713,0.2615295046048055,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.2349,1.011,-8.9511,-4.70414434620379,0.0299265138600162,Benign,0.238,benign,-3.512,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228W,NP_000537:p.Asp228Trp,,,,,saturation_mutlist,,,,,,,,-0.08445,0.34088379502296445,,-0.0644629386059651,,-0.07445646930298255,,Neutral,Neutral,,Neutral,0.27880323950937175,,0.08766195676201717,0.21868,,-0.23702613750891532,,-0.009173068754457656,,Neutral,,Neutral,,0.08588697223854198,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.3362,1.011,-22.239,-6.32011535407786,0.5408863750944581,Uncertain,0.8591,pathogenic,-4.241,available,https://doi.org/10.1101/2022.10.22.513328 +D228Y,NP_000537:p.Asp228Tyr,"hg19,17:g.7577599C>A, hg38,17:g.7674281C>A",,,0.849,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2450759,Likely benign,1,,,,,-0.20849,0.38121148347854616,-0.3072533333333333,0.2524182144421568,-0.25787166666666667,0.02196410722107839,Neutral,Neutral,Neutral,Neutral,Neutral,0.32675749625372813,0.3629846549863445,0.07490318730370835,-0.12334,-0.53061,0.1186474433900867,-0.326975,-0.0023462783049566505,Neutral,Neutral,Neutral,Neutral,0.30577585352672965,0.07913599236068981,73.361,15.197,86.985,17.958,,True,73.361,,neutral,neutral,neutral,,True,86.985,,neutral,neutral,neutral,uncertain,,-0.3007,1.011,-22.239,-6.32011535407786,0.7322515131696187,Pathogenic,0.3148,benign,-4.14,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C229A,NP_000537:p.Cys229Ala,,,,,saturation_mutlist,,,,,,,,0.16095,-0.009736576080322263,,0.38529791152155535,,0.2731239557607777,,Neutral,Neutral,,Neutral,0.19198362325339738,,0.4492191414621677,-0.15574,,0.15237459306355933,,-0.0016827034682203312,,Neutral,,Neutral,,0.2584891736436146,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,uncertain,,-0.2384,1.9363,-7.3604,-1.82769194347323,0.0020902398359971,Benign,0.495,ambiguous,-3.37,available,https://doi.org/10.1101/2022.10.22.513328 +C229D,NP_000537:p.Cys229Asp,,,,,saturation_mutlist,,,,,,,,1.75094,1.440087149143219,,1.7986051736329607,,1.7747725868164803,,Neutral,Uncertain,,Neutral,0.37918680792299136,,0.9334000159003738,1.55189,,1.4007214692964183,,1.4763057346482091,,Neutral,,Neutral,,0.6281146148218815,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,uncertain,,-0.4216,1.9363,-22.2332,-3.51317249077547,0.0894574346804364,Benign,0.7967,pathogenic,-4.036,available,https://doi.org/10.1101/2022.10.22.513328 +C229E,NP_000537:p.Cys229Glu,,,,,saturation_mutlist,,,,,,,,1.29632,1.2942670392990112,,1.6910055152612593,,1.4936627576306296,,Neutral,Uncertain,,Neutral,0.37792697761081884,,1.1032380931934311,0.72788,,1.0565276685295337,,0.8922038342647669,,Neutral,,Neutral,,0.6271056053293165,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.4092,1.9363,-22.2332,-3.90977940080524,0.0846914174269106,Benign,0.8604,pathogenic,-3.93,available,https://doi.org/10.1101/2022.10.22.513328 +C229F,NP_000537:p.Cys229Phe,"hg19,17:g.7577595C>A, hg38,17:g.7674277C>A",,,0.401,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.41679,0.264051194190979,-1.0106566666666668,-0.28863543968296934,-0.2969333333333334,0.06407728015851533,Neutral,Neutral,Neutral,Neutral,Neutral,0.13696532656977486,0.32511139530252636,0.3892899785347749,0.37711,0.9545333333333333,-0.679102517186783,0.6658216666666666,-0.15099625859339152,Neutral,Neutral,Neutral,Neutral,2.837826601988845,0.9604127769956761,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.1987,1.9363,-0.7606,-0.9953252826484,5.3352857883834094e-05,Benign,0.1155,benign,-3.154,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C229G,NP_000537:p.Cys229Gly,"hg19,17:g.7577596A>C, hg38,17:g.7674278A>C",,,0.738,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1026715,Uncertain significance,2,,,,,0.95031,0.8341437482833862,1.4536266666666666,2.242671530718649,1.2019683333333333,1.5964907653593245,Neutral,Uncertain,Neutral,Neutral,Neutral,0.30337952917406863,0.27117647161130254,0.6349649075260551,0.04938,1.2292499999999997,1.8690641975289293,0.6393149999999999,0.9592220987644646,Neutral,Neutral,Neutral,Neutral,0.5536592887929062,0.46741667217468463,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,uncertain,,-0.2246,1.9363,-6.1381,-2.85968821708073,0.0002614157557203,Benign,0.2485,benign,-3.472,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C229H,NP_000537:p.Cys229His,,,,,saturation_mutlist,,,,,,,,2.24919,0.37025296449661255,,0.48054599465697434,,1.3648679973284872,,Uncertain,Neutral,,Neutral,0.23088881334198083,,0.23099373567354864,0.77848,,0.04839840046817945,,0.4134392002340897,,Neutral,,Neutral,,0.7596942349612477,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.3441,1.9363,-7.3604,-1.27444965076117,0.0007008657332372,Benign,0.437,ambiguous,-3.449,available,https://doi.org/10.1101/2022.10.22.513328 +C229I,NP_000537:p.Cys229Ile,,,,,saturation_mutlist,,,,,,,,0.74573,0.3510253667831421,,0.07377042932896555,,0.4097502146644828,,Neutral,Neutral,,Neutral,0.35506324759066593,,0.5503200617251915,0.93009,,-0.8389774660298771,,0.04555626698506143,,Neutral,,Neutral,,0.2771218173805515,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.2527,1.9363,-5.486,-2.19947137977006,0.004808843010535,Benign,0.5593,ambiguous,-3.584,available,https://doi.org/10.1101/2022.10.22.513328 +C229K,NP_000537:p.Cys229Lys,,,,,saturation_mutlist,,,,,,,,0.36534,0.5724929404258728,,2.207865974773364,,1.286602987386682,,Uncertain,Neutral,,Neutral,0.30648038123165305,,1.2916889183089761,-0.05165,,1.164961392883972,,0.556655696441986,,Neutral,,Neutral,,0.8552220278151054,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.4098,1.9363,-22.2332,-4.61929382670825,0.1749814866774836,Benign,0.8663,pathogenic,-3.946,available,https://doi.org/10.1101/2022.10.22.513328 +C229L,NP_000537:p.Cys229Leu,,,,,saturation_mutlist,,,,,,,,0.43839,0.6922101330757141,,-0.17841259619096975,,0.1299887019045151,,Neutral,Neutral,,Neutral,0.20641129183042634,,0.6323919738281644,0.03239,,-1.047712210220819,,-0.5076611051104095,,Neutral,,Neutral,,0.5385114242100099,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.3712,1.9363,-22.2332,-2.82853841523471,0.0099001091902112,Benign,0.6073,pathogenic,-3.418,available,https://doi.org/10.1101/2022.10.22.513328 +C229M,NP_000537:p.Cys229Met,,,,,saturation_mutlist,,,,,,,,-0.47201,0.48684542894363403,,0.19351720609008974,,-0.1392463969549551,,Neutral,Neutral,,Neutral,0.156125334260285,,0.5905586946106021,-0.36898,,-0.2857720419973971,,-0.32737602099869856,,Neutral,,Neutral,,0.7019169838709299,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.2498,1.9363,-4.858,-2.21619368941055,0.0005552331939442,Benign,0.6412,pathogenic,-3.565,available,https://doi.org/10.1101/2022.10.22.513328 +C229N,NP_000537:p.Cys229Asn,,,,,saturation_mutlist,,,,,,,,0.9807,0.8823097634315491,,0.8615259720340903,,0.9211129860170452,,Neutral,Neutral,,Neutral,0.33507051671249727,,0.5127881170974145,0.5767,,0.5067783317042772,,0.5417391658521387,,Neutral,,Neutral,,0.38558739059484376,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.2962,1.9363,-8.9453,-2.78368040727698,0.0025004147659933,Benign,0.5546,ambiguous,-3.708,available,https://doi.org/10.1101/2022.10.22.513328 +C229P,NP_000537:p.Cys229Pro,,,,,saturation_mutlist,,,,,,,,2.07809,1.2505433440208436,,5.273452300786571,,3.6757711503932855,,Uncertain,Uncertain,,Destabilizing,0.273256641230972,,0.698884856287456,0.65691,,2.1658851056943615,,1.4113975528471807,,Uncertain,,Neutral,,0.4481091913770361,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,uncertain,,-0.4326,1.9363,-22.2332,-3.78261747030186,0.277559208730174,Benign,0.9701,pathogenic,-3.92,available,https://doi.org/10.1101/2022.10.22.513328 +C229Q,NP_000537:p.Cys229Gln,,,,,saturation_mutlist,,,,,,,,0.66049,0.6076976299285889,,0.9393898222325802,,0.7999399111162901,,Neutral,Neutral,,Neutral,0.27482234191370786,,0.7930097550628216,0.32125,,0.59396355318352,,0.45760677659175997,,Neutral,,Neutral,,0.6831513254347047,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.388,1.9363,-22.2332,-4.30447399895388,0.6042874337545499,Uncertain,0.6854,pathogenic,-3.925,available,https://doi.org/10.1101/2022.10.22.513328 +C229R,NP_000537:p.Cys229Arg,"hg19,17:g.7577596A>G, hg38,17:g.7674278A>G",,7.9529819706e-06,0.754,"COSMIC,ClinVar,saturation_mutlist",420137,Conflicting classifications of pathogenicity,1,,,,,0.80403,0.46659767627716064,1.4632666666666667,1.4471947223536799,1.1336483333333334,1.1256123611768398,Neutral,Neutral,Neutral,Neutral,Neutral,0.28916911557815167,0.8338651143653605,1.0527456092857586,0.10309,2.00465,0.2887724471907116,1.0538699999999999,0.1959312235953558,Uncertain,Neutral,Neutral,Neutral,0.7660079326395168,0.7931301017613781,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.2937,1.9363,-7.9454,-3.21722478031866,0.0125933605659176,Benign,0.5548,ambiguous,-3.591,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C229S,NP_000537:p.Cys229Ser,"hg19,17:g.7577595C>G, hg19,17:g.7577596A>T, hg38,17:g.7674277C>G, hg38,17:g.7674278A>T",,,"0.535, 0.600","cBioPortal,COSMIC,ClinVar,saturation_mutlist",582302,Conflicting classifications of pathogenicity,1,,,,,0.81109,0.33118443727493285,0.8252866666666666,1.4171400088174284,0.8181883333333333,1.1141150044087142,Neutral,Neutral,Neutral,Neutral,Neutral,0.21189094728493363,0.13344572438094654,0.6553303037353483,0.3923,0.70567,0.8861426701824104,0.5489850000000001,0.6392213350912053,Neutral,Neutral,Neutral,Neutral,0.6986868975919519,0.4190202992444929,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,uncertain,,-0.2196,1.9363,-5.486,-1.48349505430365,0.0001062543235567,Benign,0.2846,benign,-3.098,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C229T,NP_000537:p.Cys229Thr,,,,,saturation_mutlist,,,,,,,,0.91082,0.31861886501312253,,0.723607478046513,,0.8172137390232566,,Neutral,Neutral,,Neutral,0.20733447098192456,,0.4753464561640239,0.55735,,0.06678747469713049,,0.3120687373485653,,Neutral,,Neutral,,0.07998526615119271,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.2639,1.9363,-7.3604,-1.51271884520354,5.5648685070912027e-05,Benign,0.5127,ambiguous,-3.35,available,https://doi.org/10.1101/2022.10.22.513328 +C229V,NP_000537:p.Cys229Val,,,,,saturation_mutlist,,,,,,,,0.19963,-0.10419205665588378,,-0.23455286795668698,,-0.017461433978343488,,Neutral,Neutral,,Neutral,0.3547869971938477,,0.39489007350631905,0.19297,,-0.8625948841183492,,-0.3348124420591746,,Neutral,,Neutral,,0.12382033987225775,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.2633,1.9363,-7.9454,-2.35478821914342,0.0023236333267171,Benign,0.4695,ambiguous,-3.472,available,https://doi.org/10.1101/2022.10.22.513328 +C229W,NP_000537:p.Cys229Trp,"hg19,17:g.7577594A>C",,,0.594,"cBioPortal,saturation_mutlist",,,,,,,,2.26447,0.6088375902175903,-0.5975033333333334,0.11459739190182212,0.8334833333333334,1.189533695950911,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.25844559919904386,0.07693932342364918,0.39968813143744153,1.19317,4.839226666666667,-0.45590385644244363,3.0161983333333335,0.36863307177877824,Uncertain,Neutral,Destabilizing,Neutral,7.7517504221319085,1.4589411273599255,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.2304,1.9363,-6.3605,-1.05331855646119,0.005445517137338,Benign,0.3728,ambiguous,-3.472,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C229Y,NP_000537:p.Cys229Tyr,"hg19,17:g.7577595C>T, hg38,17:g.7674277C>T",,,0.389,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",419040,Conflicting classifications of pathogenicity,1,,,,,0.63188,0.3278176140785217,-0.9349166666666666,0.10642523432638935,-0.1515183333333333,0.3691526171631947,Neutral,Neutral,Neutral,Neutral,Neutral,0.1971418980586406,0.27114883690614566,0.2857396567023395,0.51509,1.29206,-0.39536340817217414,0.903575,0.059863295913912956,Neutral,Neutral,Neutral,Neutral,3.534470478878932,1.2083803946169542,17.257,10.433,26.295,14.685,,False,17.257,,neutral,neutral,neutral,,False,26.295,,neutral,neutral,neutral,neutral,,-0.2267,1.9363,-4.4219,0.0338896257398098,3.77156937776905e-07,Benign,0.1447,benign,-3.098,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T230A,NP_000537:p.Thr230Ala,"hg19,17:g.7577593T>C, hg38,17:g.7674275T>C",,,0.856,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",953956,Uncertain significance,2,,,,,0.61932,0.7955269718170166,0.9809533333333332,0.3557913256200011,0.8001366666666666,0.4875556628100005,Neutral,Neutral,Neutral,Neutral,Neutral,0.43507821071397956,0.4612504229687913,0.1857798651185187,-1.60659,0.5747166666666668,0.011024658156647904,-0.5159366666666666,-0.797782670921676,Neutral,Neutral,Neutral,Neutral,0.38701709129643824,0.12518690053561313,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,uncertain,,-0.2241,0.2248,-6.9513,-0.771978531034543,0.4226653637066954,Uncertain,0.1821,benign,-3.662,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T230C,NP_000537:p.Thr230Cys,,,,,saturation_mutlist,,,,,,,,0.24313,0.3193469285964966,,0.6072925052679456,,0.42521125263397286,,Neutral,Neutral,,Neutral,0.37300813124777743,,0.29679904373615046,-0.99848,,0.5847749134663925,,-0.20685254326680375,,Neutral,,Neutral,,0.11337474545380652,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,uncertain,,-0.3379,0.2248,-22.239,-4.25734855828884,0.7304015856328429,Pathogenic,0.5563,ambiguous,-4.054,available,https://doi.org/10.1101/2022.10.22.513328 +T230D,NP_000537:p.Thr230Asp,,,,,saturation_mutlist,,,,,,,,1.02998,1.9238105010986328,,1.3109865674270875,,1.1704832837135437,,Neutral,Uncertain,,Neutral,0.5411032914634277,,0.6410187848371913,1.67171,,1.1914443826868681,,1.431577191343434,,Neutral,,Neutral,,0.46878947828903145,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,uncertain,,-0.4177,0.2248,-22.239,-5.19335573052498,0.8593369385210501,Pathogenic,0.9573,pathogenic,-4.49,available,https://doi.org/10.1101/2022.10.22.513328 +T230E,NP_000537:p.Thr230Glu,,,,,saturation_mutlist,,,,,,,,0.84404,1.5944935059547425,,1.1147601294162224,,0.9794000647081111,,Neutral,Uncertain,,Neutral,0.5417937522421354,,0.8216818626567658,0.71886,,1.240123056120524,,0.9794915280602621,,Neutral,,Neutral,,0.3843924361214748,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,neutral,,-0.393,0.2248,-22.239,-6.41578450221753,0.7896261498533217,Pathogenic,0.9391,pathogenic,-4.35,available,https://doi.org/10.1101/2022.10.22.513328 +T230F,NP_000537:p.Thr230Phe,,,,,saturation_mutlist,,,,,,,,-1.13058,0.6187749814987182,,-0.8323373119699767,,-0.9814586559849883,,Neutral,Neutral,,Neutral,0.44692445619552224,,0.3805253810673785,5.9725,,-0.24518425404091382,,2.863657872979543,,Uncertain,,Uncertain,,0.3493739153411397,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,neutral,,-0.4094,0.2248,-22.239,-5.25335794905371,0.2875419588663445,Benign,0.804,pathogenic,-4.061,available,https://doi.org/10.1101/2022.10.22.513328 +T230G,NP_000537:p.Thr230Gly,,,,,saturation_mutlist,,,,,,,,1.61171,1.7031641674041749,,1.7106019102631844,,1.6611559551315922,,Neutral,Uncertain,,Neutral,0.45672963367788894,,0.2780202135709789,-0.74714,,1.3696903397402547,,0.3112751698701273,,Neutral,,Neutral,,0.0025969619109299275,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,uncertain,,-0.3756,0.2248,-22.239,-7.26080279635167,0.8576741900955198,Pathogenic,0.7016,pathogenic,-4.386,available,https://doi.org/10.1101/2022.10.22.513328 +T230H,NP_000537:p.Thr230His,,,,,saturation_mutlist,,,,,,,,0.68049,0.8307909452915192,,-0.06031480224665797,,0.31008759887667103,,Neutral,Neutral,,Neutral,0.4824065731270598,,0.4280271222534271,6.03414,,0.21094097945752588,,3.1225404897287627,,Uncertain,,Destabilizing,,0.32424985910042,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,neutral,,-0.3896,0.2248,-22.239,-6.15585463465824,0.8296370399299109,Pathogenic,0.7994,pathogenic,-4.388,available,https://doi.org/10.1101/2022.10.22.513328 +T230I,NP_000537:p.Thr230Ile,"hg19,17:g.7577592G>A, hg38,17:g.7674274G>A",,,0.936,"COSMIC,ClinVar,saturation_mutlist",1366616,Uncertain significance,1,,,,,-0.96928,-0.02534846544265747,-0.47007,-0.842019077740637,-0.7196750000000001,-0.9056495388703185,Neutral,Neutral,Neutral,Neutral,Neutral,0.43759370377276413,0.21597872163710943,0.7842563913001721,-0.3586,0.32278999999999997,0.1085295096300537,-0.017905000000000004,-0.12503524518497314,Neutral,Neutral,Neutral,Neutral,0.3315615861344616,0.3620166492301988,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,neutral,,-0.2551,0.2248,-7.9512,-2.85517953282881,0.0265049262488396,Benign,0.669,pathogenic,-3.625,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T230K,NP_000537:p.Thr230Lys,,,,,saturation_mutlist,,,,,,,,-0.1195,0.7731319677829742,,0.6407870170369646,,0.2606435085184823,,Neutral,Neutral,,Neutral,0.5630330647714301,,0.7973370421595813,-0.00249,,1.487621408221761,,0.7425657041108804,,Neutral,,Neutral,,0.2505657499873418,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,neutral,,-0.3852,0.2248,-22.239,-6.46390158073096,0.7455115628828646,Pathogenic,0.9088,pathogenic,-4.272,available,https://doi.org/10.1101/2022.10.22.513328 +T230L,NP_000537:p.Thr230Leu,,,,,saturation_mutlist,,,,,,,,-1.25037,0.675997040271759,,-0.7391926853570858,,-0.9947813426785429,,Neutral,Neutral,,Neutral,0.570921848673852,,0.7732472643756008,-1.11784,,-0.455431117747709,,-0.7866355588738545,,Neutral,,Neutral,,0.2890611508914267,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,neutral,,-0.3799,0.2248,-22.239,-5.33684486116727,0.7988843562123162,Pathogenic,0.4796,ambiguous,-4.192,available,https://doi.org/10.1101/2022.10.22.513328 +T230M,NP_000537:p.Thr230Met,,,,,saturation_mutlist,,,,,,,,-1.72023,0.59788081407547,,-0.18454427980327678,,-0.9523871399016384,,Neutral,Neutral,,Neutral,0.46203895964396835,,0.6769220541570842,-1.69728,,-0.19996589019542488,,-0.9486229450977124,,Neutral,,Neutral,,0.2608063571545292,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,neutral,,-0.3469,0.2248,-22.239,-4.53851018335458,0.5166988321194547,Uncertain,0.2973,benign,-3.968,available,https://doi.org/10.1101/2022.10.22.513328 +T230N,NP_000537:p.Thr230Asn,"hg38,17:g.7674274G>T",,,0.875,"COSMIC,saturation_mutlist",,,,,,,,0.32948,1.264195168018341,1.6119066666666668,0.4459450398620614,0.9706933333333334,0.38771251993103073,Neutral,Neutral,Uncertain,Neutral,Neutral,0.4468926702741663,0.4633595347267845,0.4461388161307621,0.36126,0.8418399999999999,0.3656878564843192,0.60155,0.3634739282421596,Neutral,Neutral,Neutral,Neutral,0.30238938506501845,0.2516350004856629,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,uncertain,,-0.3577,0.2248,-22.239,-5.17123924654819,0.6687951994826158,Uncertain,0.6742,pathogenic,-4.151,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T230P,NP_000537:p.Thr230Pro,"hg19,17:g.7577593T>G, hg19,17:g.7674275T>G, hg38,17:g.7674275T>G",,,0.920,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",4539743,,,Uncertain significance,1,,,0.17445,1.256482993364334,2.7292533333333338,3.468853836484154,1.4518516666666668,1.8216519182420772,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.9174307364688705,1.5044277349728554,1.2673998670832338,1.01986,1.3787966666666664,5.364209326713197,1.1993283333333333,3.1920346633565986,Neutral,Uncertain,Neutral,Destabilizing,1.2101209928579686,0.49422628309198563,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,uncertain,,-0.4664,0.2248,-22.239,-7.26080279635167,0.8692590936818427,Pathogenic,0.8389,pathogenic,-4.396,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T230Q,NP_000537:p.Thr230Gln,,,,,saturation_mutlist,,,,,,,,0.14572,1.076666580438614,,0.5720156619801795,,0.35886783099008973,,Neutral,Uncertain,,Neutral,0.45806033215423186,,0.6264473938498318,-0.44066,,0.6626966361444776,,0.1110183180722388,,Neutral,,Neutral,,0.22013344517780647,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,neutral,,-0.3672,0.2248,-22.239,-6.07847053462105,0.4718694486383499,Uncertain,0.8123,pathogenic,-4.157,available,https://doi.org/10.1101/2022.10.22.513328 +T230R,NP_000537:p.Thr230Arg,,,,,saturation_mutlist,,,,,,,,0.01905,0.5040488958358764,,-0.002455384559332807,,0.008297307720333597,,Neutral,Neutral,,Neutral,0.4889596295234604,,0.6192177924520592,0.71103,,0.7269815941983824,,0.7190057970991912,,Neutral,,Neutral,,0.10452027290990183,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,neutral,,-0.388,0.2248,-22.239,-5.82084561380598,0.7403451958682002,Pathogenic,0.8243,pathogenic,-4.264,available,https://doi.org/10.1101/2022.10.22.513328 +T230S,NP_000537:p.Thr230Ser,"hg19,17:g.7577593T>A, hg38,17:g.7674275T>A",,,0.863,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.85502,0.5749464082717896,1.16338,0.8448945196202139,1.0092,0.849957259810107,Neutral,Neutral,Neutral,Neutral,Neutral,0.2258748451807091,0.16357199576944706,0.3053594230616013,-0.61554,0.9956933333333334,0.8698234990127408,0.19007666666666673,0.12714174950637042,Neutral,Neutral,Neutral,Neutral,0.5385991855627791,0.05340004203658169,22.014,8.307,12.195,7.462,,False,22.014,,neutral,,,,False,12.195,,neutral,,,uncertain,,-0.1827,0.2248,-5.9513,-1.94343831854702,2.9945201892759925e-05,Benign,0.2275,benign,-3.412,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T230V,NP_000537:p.Thr230Val,,,,,saturation_mutlist,,,,,,,,-0.42515,-0.14968453884124755,,-0.9037509986238667,,-0.6644504993119333,,Neutral,Neutral,,Neutral,0.32986500837651606,,0.5574690867267472,-0.83058,,-0.1592008340041588,,-0.49489041700207936,,Neutral,,Neutral,,0.3093608588200932,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,neutral,,-0.3156,0.2248,-22.239,-4.2037386574677,0.236102291201075,Benign,0.4128,ambiguous,-3.646,available,https://doi.org/10.1101/2022.10.22.513328 +T230W,NP_000537:p.Thr230Trp,,,,,saturation_mutlist,,,,,,,,-0.80025,0.7376697254180908,,-0.6261173647970516,,-0.7131836823985258,,Neutral,Neutral,,Neutral,0.5781592326854301,,0.634064262270609,8.02055,,-0.09828483983868337,,3.9611325800806583,,Uncertain,,Destabilizing,,0.4555908607222898,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,neutral,,-0.4023,0.2248,-22.239,-6.15585463465824,0.8473940187197,Pathogenic,0.9531,pathogenic,-4.703,available,https://doi.org/10.1101/2022.10.22.513328 +T230Y,NP_000537:p.Thr230Tyr,,,,,saturation_mutlist,,,,,,,,-0.91965,0.589187695980072,,-0.538681370253664,,-0.729165685126832,,Neutral,Neutral,,Neutral,0.4983662782988559,,0.47140763775717515,8.33222,,0.06823540161316255,,4.200227700806581,,Uncertain,,Destabilizing,,0.4011442798684419,22.014,8.307,12.195,7.462,,False,22.014,,uncertain,,,,False,12.195,,uncertain,,,neutral,,-0.4108,0.2248,-22.239,-4.43625447924018,0.1781627354344928,Benign,0.8651,pathogenic,-4.183,available,https://doi.org/10.1101/2022.10.22.513328 +T231A,NP_000537:p.Thr231Ala,"hg19,17:g.7577590T>C, hg38,17:g.7674272T>C",,,0.905,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",863153,Uncertain significance,2,,,,,0.71257,0.7352165317535401,0.9324266666666666,0.7427594214564351,0.8224983333333333,0.7276647107282176,Neutral,Neutral,Neutral,Neutral,Neutral,0.1947119259101196,0.13598690141170047,0.10506304956545814,0.63442,0.4259633333333333,0.6626575581638466,0.5301916666666666,0.6485387790819233,Neutral,Neutral,Neutral,Neutral,0.26254959840422953,0.24511184754677276,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.3092,0.1477,-22.239,-0.750209573914153,0.3286726156404574,Uncertain,0.4094,ambiguous,-3.625,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T231C,NP_000537:p.Thr231Cys,,,,,saturation_mutlist,,,,,,,,0.23502,0.17577016353607178,,0.8747662508557195,,0.5548931254278597,,Neutral,Neutral,,Neutral,0.1285075870119352,,0.1633975410277837,0.39195,,0.9193724856164014,,0.6556612428082007,,Neutral,,Neutral,,0.17260182379883846,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.345,0.1477,-22.239,-4.69457965984154,0.8665508989929763,Pathogenic,0.8882,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328 +T231D,NP_000537:p.Thr231Asp,,,,,saturation_mutlist,,,,,,,,1.11056,1.6614285135269165,,1.0843307490571108,,1.0974453745285553,,Neutral,Uncertain,,Neutral,0.33361256874885553,,0.15008538571542057,1.40258,,0.606997168265205,,1.0047885841326025,,Neutral,,Neutral,,0.28001417627794695,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.4248,0.1477,-22.239,-6.71297729684607,0.5255867794954983,Uncertain,0.9622,pathogenic,-4.244,available,https://doi.org/10.1101/2022.10.22.513328 +T231E,NP_000537:p.Thr231Glu,,,,,saturation_mutlist,,,,,,,,0.46141,1.0531307673454284,,0.624045759219107,,0.5427278796095535,,Neutral,Uncertain,,Neutral,0.3424285368638548,,0.16589238341071202,0.3505,,0.3981212168632531,,0.37431060843162656,,Neutral,,Neutral,,0.26626066352363986,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.4001,0.1477,-22.239,-6.47717403267022,0.3806608278917238,Uncertain,0.9355,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +T231F,NP_000537:p.Thr231Phe,,,,,saturation_mutlist,,,,,,,,0.74436,0.3997683691978455,,-0.5683986224898491,,0.08798068875507548,,Neutral,Neutral,,Neutral,0.2266855692759766,,0.5004666177806392,0.34674,,-0.46410144640002926,,-0.058680723200014634,,Neutral,,Neutral,,0.23089813227765582,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.4165,0.1477,-22.239,-6.44258281894111,0.789012916864202,Pathogenic,0.9004,pathogenic,-4.186,available,https://doi.org/10.1101/2022.10.22.513328 +T231G,NP_000537:p.Thr231Gly,,,,,saturation_mutlist,,,,,,,,1.51817,1.5990168809890748,,2.2410606886395956,,1.8796153443197978,,Uncertain,Uncertain,,Neutral,0.24233770359707676,,0.14855021432033677,1.31011,,1.7380251130304873,,1.5240675565152437,,Neutral,,Neutral,,0.4133880206448055,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.3827,0.1477,-22.239,-7.80657835516367,0.8252082320998753,Pathogenic,0.8975,pathogenic,-4.295,available,https://doi.org/10.1101/2022.10.22.513328 +T231H,NP_000537:p.Thr231His,,,,,saturation_mutlist,,,,,,,,1.25839,1.12146338224411,,0.11635000600342614,,0.687370003001713,,Neutral,Uncertain,,Neutral,0.310206892745143,,0.3453976752743474,1.16743,,-0.025839450443380634,,0.5707952747783097,,Neutral,,Neutral,,0.18301676846084847,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.3967,0.1477,-22.239,-6.11656078059592,0.3757263853028462,Uncertain,0.9099,pathogenic,-4.036,available,https://doi.org/10.1101/2022.10.22.513328 +T231I,NP_000537:p.Thr231Ile,"hg19,17:g.7577589G>A, hg38,17:g.7674271G>A",,,0.942,"COSMIC,ClinVar,saturation_mutlist",458557,Uncertain significance,2,,,Tier II - Potential,1,-0.79805,-0.6177080249786377,-1.3572566666666666,-0.9692400366458743,-1.0776533333333334,-0.8836450183229372,Neutral,Neutral,Neutral,Neutral,Neutral,0.20941505843901187,0.0790834354056243,0.2006582353718793,-0.60873,-1.2001099999999998,-0.7670493918734276,-0.9044199999999999,-0.6878896959367138,Neutral,Neutral,Neutral,Neutral,0.011127464521024828,0.2822992367821844,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.2571,0.1477,-6.9513,-4.06529226224259,0.026361241822399,Benign,0.629,pathogenic,-3.482,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T231K,NP_000537:p.Thr231Lys,,,,,saturation_mutlist,,,,,,,,-0.28638,1.3009380745887755,,0.6503622161889692,,0.18199110809448457,,Neutral,Uncertain,,Neutral,0.2672320375413654,,0.11142509466168703,-0.38084,,0.3722760178834785,,-0.004281991058260742,,Neutral,,Neutral,,0.1584155506208831,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.3245,0.1477,-8.9511,-4.41711862174608,0.0071473746229998,Benign,0.9047,pathogenic,-3.779,available,https://doi.org/10.1101/2022.10.22.513328 +T231L,NP_000537:p.Thr231Leu,,,,,saturation_mutlist,,,,,,,,-0.88369,0.13629368782043458,,-0.9556734923273007,,-0.9196817461636504,,Neutral,Neutral,,Neutral,0.18427896416685974,,0.16555551995571852,-0.60928,,-0.6778177767624888,,-0.6435488883812444,,Neutral,,Neutral,,0.20237651846837004,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.387,0.1477,-22.239,-5.78473906010772,0.1310760415523605,Benign,0.438,ambiguous,-3.69,available,https://doi.org/10.1101/2022.10.22.513328 +T231M,NP_000537:p.Thr231Met,,,,,saturation_mutlist,,,,,,,,-0.90282,0.3725896382331848,,-0.25614235646676153,,-0.5794811782333807,,Neutral,Neutral,,Neutral,0.12889425841081625,,0.2318268996901077,-0.45182,,-0.10408752229719469,,-0.2779537611485973,,Neutral,,Neutral,,0.2451192394687646,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.354,0.1477,-22.239,-6.2330233517437,0.739447417024613,Pathogenic,0.3261,benign,-4.094,available,https://doi.org/10.1101/2022.10.22.513328 +T231N,NP_000537:p.Thr231Asn,"hg19,17:g.7577589G>T, hg38,17:g.7674271G>T",,,0.885,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.04491,1.5187347769737243,0.6163266666666666,0.5727847883518365,0.8306183333333332,0.8088473941759182,Neutral,Neutral,Uncertain,Neutral,Neutral,0.27402866215760113,0.20620983751724573,0.1631735432232793,0.93602,1.0742633333333333,0.39132610080478925,1.0051416666666666,0.6636730504023947,Neutral,Neutral,Neutral,Neutral,0.12287213037227852,0.20069823989471716,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.3648,0.1477,-22.239,-4.86983639876597,0.4706144361447789,Uncertain,0.7626,pathogenic,-3.818,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T231P,NP_000537:p.Thr231Pro,"hg19,17:g.7577590T>G, hg38,17:g.7674272T>G",,,0.959,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.01928,1.4766987228393555,0.8393433333333333,2.2359087166746665,0.9293116666666666,1.6275943583373333,Neutral,Uncertain,Uncertain,Neutral,Neutral,0.29492946192639724,0.05868760024248924,0.9430119928292722,1.07696,0.3473933333333334,1.4700665388875125,0.7121766666666667,1.273513269443756,Neutral,Neutral,Neutral,Neutral,0.8366425381779777,0.40603049821980935,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.4006,0.1477,-7.9512,-5.90431671926836,0.2484307165040373,Benign,0.8364,pathogenic,-3.92,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T231Q,NP_000537:p.Thr231Gln,,,,,saturation_mutlist,,,,,,,,0.32701,1.1114454221725465,,0.4811799466874331,,0.4040949733437166,,Neutral,Uncertain,,Neutral,0.26555227722166147,,0.16333085074783144,0.14392,,0.4599095984953964,,0.3019147992476982,,Neutral,,Neutral,,0.20757673806952845,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.3743,0.1477,-22.239,-6.42307784301514,0.3247127276150378,Uncertain,0.8532,pathogenic,-3.897,available,https://doi.org/10.1101/2022.10.22.513328 +T231R,NP_000537:p.Thr231Arg,,,,,saturation_mutlist,,,,,,,,-0.03247,1.1822781682014465,,0.09007722623654994,,0.028803613118274972,,Neutral,Uncertain,,Neutral,0.2534061133053936,,0.1471014633108655,-0.11798,,0.0294489911908265,,-0.04426550440458675,,Neutral,,Neutral,,0.12468777640126577,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.3951,0.1477,-22.239,-5.0623118032494,0.2588560785715943,Benign,0.858,pathogenic,-3.946,available,https://doi.org/10.1101/2022.10.22.513328 +T231S,NP_000537:p.Thr231Ser,"hg19,17:g.7577589G>C, hg38,17:g.7674271G>C, hg38,17:g.7674272T>A",,,"0.916, 0.922","COSMIC,ClinVar,saturation_mutlist",921142,Uncertain significance,2,,,,,1.18679,0.8118268752098083,1.3414966666666668,1.0643626091370904,1.2641433333333334,1.1255763045685452,Neutral,Neutral,Neutral,Neutral,Neutral,0.1427833774985571,0.1539464032996188,0.19306693494384805,0.9002,1.2222233333333334,0.765665509517807,1.0612116666666667,0.8329327547589035,Neutral,Neutral,Neutral,Neutral,0.33958187744473184,0.2974356605602711,30.802,7.676,44.52,10.015,,False,30.802,,neutral,,,,False,44.52,,neutral,,,uncertain,,-0.2051,0.1477,-8.9511,-4.12712806788995,0.2161090983897186,Benign,0.5804,pathogenic,-3.694,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T231V,NP_000537:p.Thr231Val,,,,,saturation_mutlist,,,,,,,,-0.46615,-0.43703585624694824,,-0.8177431464516718,,-0.6419465732258359,,Neutral,Neutral,,Neutral,0.1594125100189894,,0.12303473421768212,-0.32482,,-0.5709964038439245,,-0.44790820192196223,,Neutral,,Neutral,,0.29680226481259403,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.3227,0.1477,-22.239,-5.18538203131054,0.0052048249500055,Benign,0.3308,benign,-3.58,available,https://doi.org/10.1101/2022.10.22.513328 +T231W,NP_000537:p.Thr231Trp,,,,,saturation_mutlist,,,,,,,,1.02551,0.25994394063949583,,-0.6391978712806853,,0.19315606435965732,,Neutral,Neutral,,Neutral,0.3112360101501091,,0.4318170532272852,0.83875,,-0.6008029197559756,,0.11897354012201222,,Neutral,,Neutral,,0.19963960462592964,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.4093,0.1477,-22.239,-6.78196048107463,0.8242178821937223,Pathogenic,0.9693,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328 +T231Y,NP_000537:p.Thr231Tyr,,,,,saturation_mutlist,,,,,,,,0.65739,0.37870934724807737,,-0.2336698201859392,,0.21186008990703042,,Neutral,Neutral,,Neutral,0.29693203491165465,,0.5041801089509804,0.37659,,-0.2853036895589363,,0.045643155220531834,,Neutral,,Neutral,,0.19820255368324396,30.802,7.676,44.52,10.015,,False,30.802,,uncertain,,,,False,44.52,,uncertain,,,uncertain,,-0.4179,0.1477,-22.239,-6.78196048107463,0.8430965026229866,Pathogenic,0.9298,pathogenic,-4.377,available,https://doi.org/10.1101/2022.10.22.513328 +I232A,NP_000537:p.Ile232Ala,,,,,saturation_mutlist,,,,,,,,3.6958,2.45184193611145,,3.37580218089175,,3.535801090445875,,Destabilizing,Destabilizing,,Destabilizing,0.15462125707987037,,0.14136338596239428,0.55577,,3.06422849557975,,1.809999247789875,,Uncertain,,Neutral,,0.036866168209779754,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.3281,1.0667,-22.239,-5.13906058371721,0.6088076276725828,Uncertain,0.9749,pathogenic,-3.983,available,https://doi.org/10.1101/2022.10.22.513328 +I232C,NP_000537:p.Ile232Cys,,,,,saturation_mutlist,,,,,,,,2.63997,1.4987608814239501,,3.218572249531134,,2.9292711247655667,,Uncertain,Uncertain,,Uncertain,0.14182452045374322,,0.04747250880479479,0.4684,,3.1696935483966153,,1.8190467741983076,,Uncertain,,Neutral,,0.1882982708807212,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.3081,1.0667,-22.239,-4.28662440160875,0.4348429979763812,Uncertain,0.977,pathogenic,-3.97,available,https://doi.org/10.1101/2022.10.22.513328 +I232D,NP_000537:p.Ile232Asp,,,,,saturation_mutlist,,,,,,,,3.83103,3.4647180938720705,,4.5983021173409595,,4.214666058670479,,Destabilizing,Destabilizing,,Destabilizing,0.21951346831553406,,0.28932790880517895,2.35425,,4.360316180800348,,3.3572830904001743,,Uncertain,,Destabilizing,,0.08958600435021821,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.4522,1.0667,-22.239,-3.67836703647061,0.4617018685870929,Uncertain,0.9993,pathogenic,-4.392,available,https://doi.org/10.1101/2022.10.22.513328 +I232E,NP_000537:p.Ile232Glu,,,,,saturation_mutlist,,,,,,,,2.73294,3.0728258800506594,,4.122670276922899,,3.4278051384614496,,Uncertain,Destabilizing,,Destabilizing,0.19843805491031558,,0.37946395169322206,1.68946,,3.657858141527788,,2.673659070763894,,Uncertain,,Uncertain,,0.17586166212635812,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.4331,1.0667,-22.239,-3.73571401109809,0.0721747836705077,Benign,0.9969,pathogenic,-4.026,available,https://doi.org/10.1101/2022.10.22.513328 +I232F,NP_000537:p.Ile232Phe,"hg19,17:g.7577585_7577587delinsAAA, hg19,17:g.7577587T>A, hg19,17:g.7674269T>A, hg38,17:g.7674269T>A",,,0.840,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2827498,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,0.25511,1.0600667333602904,0.7483000000000001,1.6740591375670892,0.5017050000000001,0.9645845687835446,Neutral,Neutral,Uncertain,Neutral,Neutral,0.22972328371135986,0.4093220766910413,0.7181695874615024,4.54876,1.68991,0.9035715635639381,3.119335,2.726165781781969,Uncertain,Uncertain,Destabilizing,Uncertain,1.3823068021969653,0.11534235071470159,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.2162,1.0667,-7.9512,-3.25419754051757,0.3577311121598588,Uncertain,0.7616,pathogenic,-3.848,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232G,NP_000537:p.Ile232Gly,,,,,saturation_mutlist,,,,,,,,5.19609,3.3568799018859865,,5.423691302328571,,5.309890651164285,,Destabilizing,Destabilizing,,Destabilizing,0.1964784749965714,,0.17743384028510178,1.49462,,4.808880156694959,,3.1517500783474794,,Uncertain,,Destabilizing,,0.20626152674653164,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.4188,1.0667,-22.239,-5.84368071333109,0.5208613178197388,Uncertain,0.9972,pathogenic,-4.044,available,https://doi.org/10.1101/2022.10.22.513328 +I232H,NP_000537:p.Ile232His,,,,,saturation_mutlist,,,,,,,,2.45564,2.3910755920410156,,2.9816879435275436,,2.718663971763772,,Uncertain,Destabilizing,,Uncertain,0.18509770472197815,,0.4974955584903764,4.26629,,2.4806508644092387,,3.373470432204619,,Uncertain,,Destabilizing,,0.1806021548843442,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.4187,1.0667,-22.239,-4.04050323028216,0.3363015091277291,Uncertain,0.9943,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +I232K,NP_000537:p.Ile232Lys,,,,,saturation_mutlist,,,,,,,,2.35541,2.726593894958496,,4.75508479084153,,3.555247395420765,,Uncertain,Destabilizing,,Destabilizing,0.14784527709396864,,0.5614754200000136,2.81331,,4.193048275773534,,3.503179137886767,,Uncertain,,Destabilizing,,0.5195215395288016,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,uncertain,,-0.4256,1.0667,-22.239,-5.64713189881151,0.7166118200678055,Pathogenic,0.9948,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328 +I232L,NP_000537:p.Ile232Leu,"hg19,17:g.7577587T>G, hg38,17:g.7674269T>G",,,0.688,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",482214,Conflicting classifications of pathogenicity,1,,,,,0.21242,1.0030366802215576,1.1980766666666667,1.038074899403768,0.7052483333333334,0.6252474497018841,Neutral,Neutral,Uncertain,Neutral,Neutral,0.15484015918253838,0.3417071280432346,0.2354020154652896,-1.16124,0.20499,0.6955878349965797,-0.478125,-0.23282608250171016,Neutral,Neutral,Neutral,Neutral,0.9194852604945153,0.15859270607453585,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,uncertain,,-0.1404,1.0667,-7.9512,-1.93940326671129,0.0002225773735076,Benign,0.396,ambiguous,-3.354,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232M,NP_000537:p.Ile232Met,"hg19,17:g.7577585G>C, hg38,17:g.7674267G>C",,,0.776,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.0054,1.4802097368240357,1.7447833333333336,1.8993123187953123,0.8750916666666668,0.9523561593976562,Neutral,Neutral,Uncertain,Neutral,Neutral,0.1644578427493183,0.3278899897153854,0.30022444689527494,-0.99433,1.0735833333333333,1.3770233078520213,0.03962666666666664,0.19134665392601063,Neutral,Neutral,Neutral,Neutral,0.7681821259889406,0.26700688694483343,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,uncertain,,-0.219,1.0667,-22.239,-3.21988801821096,0.0398478296372609,Benign,0.5496,ambiguous,-3.7,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232N,NP_000537:p.Ile232Asn,"hg19,17:g.7577585_7577586delinsAT, hg19,17:g.7577586A>T, hg19,17:g.7674268A>T, hg38,17:g.7674268A>T",,,0.916,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",850008,Pathogenic/Likely pathogenic,2,,,Tier II - Potential,0,2.90955,3.1792334365844725,2.9504533333333334,3.1666899683759184,2.9300016666666666,3.038119984187959,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,0.18359515049010028,0.24764290424363503,0.17325528784320415,1.26211,2.6408133333333335,3.09212147486828,1.9514616666666669,2.17711573743414,Uncertain,Uncertain,Neutral,Uncertain,0.5340224851903606,0.15531181263230778,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.3653,1.0667,-22.239,-3.0625427012979,0.1480137911112391,Benign,0.9876,pathogenic,-3.981,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232P,NP_000537:p.Ile232Pro,,,,,saturation_mutlist,,,,,,,,5.00176,3.2276850509643555,,6.522387954892403,,5.762073977446201,,Destabilizing,Destabilizing,,Destabilizing,0.1694444205997466,,0.41467326068916777,4.76231,,7.873466084782229,,6.317888042391115,,Destabilizing,,Destabilizing,,1.7724218879554015,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.4722,1.0667,-22.239,-5.84368071333109,0.7277599087313509,Pathogenic,0.997,pathogenic,-4.457,available,https://doi.org/10.1101/2022.10.22.513328 +I232Q,NP_000537:p.Ile232Gln,,,,,saturation_mutlist,,,,,,,,2.33568,2.7921229553222657,,3.236228835662773,,2.7859544178313866,,Uncertain,Destabilizing,,Uncertain,0.17670932921289906,,0.27479459980575754,1.42049,,2.8805032599282896,,2.150496629964145,,Uncertain,,Uncertain,,0.09656924046956014,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.3928,1.0667,-22.239,-4.40456442628339,0.700273728571571,Pathogenic,0.9948,pathogenic,-4.332,available,https://doi.org/10.1101/2022.10.22.513328 +I232R,NP_000537:p.Ile232Arg,,,,,saturation_mutlist,,,,,,,,2.64792,2.7666737842559814,,3.7969568032783187,,3.2224384016391596,,Uncertain,Destabilizing,,Destabilizing,0.1476998256111299,,0.6067963713220818,4.38105,,3.215741265496172,,3.798395632748086,,Destabilizing,,Destabilizing,,0.5038118619153582,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.4524,1.0667,-22.239,-5.5544944781831,0.6437415361620338,Uncertain,0.9907,pathogenic,-4.213,available,https://doi.org/10.1101/2022.10.22.513328 +I232S,NP_000537:p.Ile232Ser,"hg19,17:g.7577586A>C, hg19,17:g.7674268A>C, hg38,17:g.7674268A>C",,,0.935,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634756,Pathogenic,1,,,,,3.70496,2.8475878715515135,4.576530000000001,4.2520019277204035,4.140745000000001,3.9784809638602017,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.16485708797791337,0.3402084162196268,0.1965534389120335,1.71412,3.619386666666666,3.9302168832779985,2.666753333333333,2.822168441638999,Uncertain,Uncertain,Uncertain,Uncertain,0.835751644343116,0.15275749966959618,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.3687,1.0667,-22.239,-5.13906058371721,0.203197629762446,Benign,0.9826,pathogenic,-4.052,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232T,NP_000537:p.Ile232Thr,"hg19,17:g.7577586A>G, hg19,17:g.7674268A>G, hg38,17:g.7674268A>G",,,0.920,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141224,Pathogenic/Likely pathogenic,2,,,,,2.63061,2.2887891864776613,2.6894533333333333,2.9028962526665603,2.660031666666667,2.7667531263332803,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,0.1356859522378956,0.27883614953748165,0.1234611357892204,1.40564,2.08458,2.8815810726198614,1.74511,2.1436105363099305,Uncertain,Uncertain,Neutral,Uncertain,0.2455638024356738,0.2508516528632238,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.2177,1.0667,-8.9511,-3.44402482831382,0.0300620563381371,Benign,0.9462,pathogenic,-3.564,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232V,NP_000537:p.Ile232Val,"hg38,17:g.7674269T>C",,,0.419,"COSMIC,saturation_mutlist",,,,,,,,1.09492,0.836779088973999,0.9091833333333333,1.043841569399688,1.0020516666666666,1.069380784699844,Neutral,Neutral,Neutral,Neutral,Neutral,0.05637925365217105,0.22858159248334547,0.02061556921573799,0.07937,0.6365066666666667,1.4039034039480462,0.35793833333333336,0.7416367019740231,Neutral,Neutral,Neutral,Neutral,0.13319848105573712,0.3024515052123666,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.0665,1.0667,-1.2789,-0.453565725717669,5.056418389032498e-10,Benign,0.1023,benign,-2.91,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232W,NP_000537:p.Ile232Trp,,,,,saturation_mutlist,,,,,,,,1.92023,1.390723705291748,,2.6165559793051045,,2.2683929896525523,,Uncertain,Uncertain,,Uncertain,0.2710716496036946,,1.147657586174352,10.16914,,1.7625869261105862,,5.965863463055293,,Uncertain,,Destabilizing,,0.49240387856153345,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.378,1.0667,-22.239,-4.5773278072054,0.7876468785053908,Pathogenic,0.9921,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328 +I232Y,NP_000537:p.Ile232Tyr,,,,,saturation_mutlist,,,,,,,,1.15083,1.2393668365478516,,2.593309294823651,,1.8720696474118255,,Uncertain,Uncertain,,Neutral,0.2697330855959214,,0.925479379789017,7.37977,,1.8710816703952335,,4.625425835197617,,Uncertain,,Destabilizing,,0.2954529676235447,3.271,2.419,4.545,4.356,,False,3.271,,neutral,neutral,neutral,,False,4.545,,neutral,neutral,neutral,damaging,,-0.3869,1.0667,-22.239,-3.79092410364773,0.0197158850767008,Benign,0.9737,pathogenic,-3.832,available,https://doi.org/10.1101/2022.10.22.513328 +H233A,NP_000537:p.His233Ala,,,,,saturation_mutlist,,,,,,,,0.49327,0.731587266921997,,0.9240363202767724,,0.7086531601383862,,Neutral,Neutral,,Neutral,0.11871198623008516,,0.0514273959338244,-0.74472,,0.79507497920885,,0.025177489604424952,,Neutral,,Neutral,,0.11525055761345024,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.2276,0.7543,-22.239,-4.06438622112277,0.1891454750961927,Benign,0.9624,pathogenic,-3.595,available,https://doi.org/10.1101/2022.10.22.513328 +H233C,NP_000537:p.His233Cys,,,,,saturation_mutlist,,,,,,,,0.48158,0.12494158267974853,,1.4007917178875775,,0.9411858589437887,,Neutral,Neutral,,Neutral,0.1561613745471654,,0.05005419704009245,-0.4543,,1.2171504247633191,,0.3814252123816596,,Neutral,,Neutral,,0.09938229367797774,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.2822,0.7543,-22.239,-4.83982206306066,0.074721208818033,Benign,0.5793,pathogenic,-3.595,available,https://doi.org/10.1101/2022.10.22.513328 +H233D,NP_000537:p.His233Asp,"hg19,17:g.7577584G>C, hg38,17:g.7674266G>C",,,0.876,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.69714,1.401452703475952,0.71882,1.0049899077176476,0.70798,0.8510649538588237,Neutral,Neutral,Uncertain,Neutral,Neutral,0.20770205692888266,0.2569498442627796,0.16856674852484102,0.20573,1.58991,0.8199284812638444,0.89782,0.5128292406319223,Neutral,Neutral,Neutral,Neutral,0.37591533364132224,0.2288193085136753,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.2749,0.7543,-22.239,-5.26877135992122,0.3535546661837397,Uncertain,0.9787,pathogenic,-3.888,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H233E,NP_000537:p.His233Glu,,,,,saturation_mutlist,,,,,,,,0.19332,0.9765497303009033,,0.769060866421134,,0.481190433210567,,Neutral,Neutral,,Neutral,0.19730709308333388,,0.23309816073240236,0.03226,,0.7840624703104523,,0.4081612351552261,,Neutral,,Neutral,,0.27138973893640983,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.2864,0.7543,-22.239,-5.30549539841015,0.5129470580525862,Uncertain,0.9877,pathogenic,-3.888,available,https://doi.org/10.1101/2022.10.22.513328 +H233F,NP_000537:p.His233Phe,,,,,saturation_mutlist,,,,,,,,-1.27785,0.3040524983406067,,-0.41453936372033096,,-0.8461946818601654,,Neutral,Neutral,,Neutral,0.14806400714038292,,0.16139517404786483,-1.33075,,-0.25808445639636635,,-0.7944172281981832,,Neutral,,Neutral,,0.3062677107882301,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.1815,0.7543,-8.9511,-2.73899604344791,0.0001861872444207,Benign,0.755,pathogenic,-3.274,available,https://doi.org/10.1101/2022.10.22.513328 +H233G,NP_000537:p.His233Gly,,,,,saturation_mutlist,,,,,,,,0.95101,1.017452404499054,,1.8375675596839154,,1.3942887798419576,,Neutral,Uncertain,,Neutral,0.30951158974032317,,0.13221529064758564,-1.11029,,1.33322118110418,,0.11146559055209004,,Neutral,,Neutral,,0.31933592049545517,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.3102,0.7543,-22.239,-5.67448993785425,0.299062538164983,Benign,0.9764,pathogenic,-3.829,available,https://doi.org/10.1101/2022.10.22.513328 +H233I,NP_000537:p.His233Ile,,,,,saturation_mutlist,,,,,,,,0.42293,0.48446065187454224,,0.30289828322376505,,0.3629141416118825,,Neutral,Neutral,,Neutral,0.3366399968614157,,0.027371809180248202,-0.56283,,0.3314175884670734,,-0.11570620576646332,,Neutral,,Neutral,,0.4304813368390564,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.3139,0.7543,-22.239,-2.95793505870609,0.0274013108889186,Benign,0.9485,pathogenic,-3.438,available,https://doi.org/10.1101/2022.10.22.513328 +H233K,NP_000537:p.His233Lys,,,,,saturation_mutlist,,,,,,,,-0.7705,0.5243260335922241,,0.6703321472348799,,-0.05008392638256004,,Neutral,Neutral,,Neutral,0.12458932032166635,,0.12443914780920576,-1.00305,,0.5055090123570012,,-0.2487704938214994,,Neutral,,Neutral,,0.13417267793568002,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.2706,0.7543,-22.239,-6.05142462374371,0.7288448461838565,Pathogenic,0.9856,pathogenic,-3.763,available,https://doi.org/10.1101/2022.10.22.513328 +H233L,NP_000537:p.His233Leu,"hg38,17:g.7674265T>A",,,0.579,"COSMIC,saturation_mutlist",,,,,,,,-1.15624,0.39188715934753415,-0.60227,-0.2181452677125635,-0.8792549999999999,-0.6871926338562817,Neutral,Neutral,Neutral,Neutral,Neutral,0.16552081050861467,0.2507284411469907,0.122009205788257,-1.07557,-0.22143,-0.41073129160388966,-0.6485,-0.7431506458019448,Neutral,Neutral,Neutral,Neutral,0.19787809243740617,0.28817065928856617,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.1657,0.7543,-0.3366,-1.13391902925994,1.45101055753223e-07,Benign,0.3678,ambiguous,-2.775,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H233M,NP_000537:p.His233Met,,,,,saturation_mutlist,,,,,,,,-1.09242,0.4506182527542114,,0.29468790325182825,,-0.39886604837408585,,Neutral,Neutral,,Neutral,0.11701266666736555,,0.07387323450006095,-1.25046,,0.0967350659194181,,-0.5768624670402909,,Neutral,,Neutral,,0.28100888657833056,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.2276,0.7543,-22.239,-2.68795692342236,0.0040939481984036,Benign,0.9371,pathogenic,-3.344,available,https://doi.org/10.1101/2022.10.22.513328 +H233N,NP_000537:p.His233Asn,,,,,saturation_mutlist,,,,,,,,0.08219,0.57036292552948,,0.6675228611230685,,0.3748564305615342,,Neutral,Neutral,,Neutral,0.11286368618768064,,0.12064329145302836,-0.47175,,0.41286330428818,,-0.02944334785590999,,Neutral,,Neutral,,0.1886737335202661,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.2344,0.7543,-22.239,-5.29135763745226,0.5070253047374477,Uncertain,0.7507,pathogenic,-3.636,available,https://doi.org/10.1101/2022.10.22.513328 +H233P,NP_000537:p.His233Pro,"hg38,17:g.7674265T>G",,,0.844,"COSMIC,saturation_mutlist",,,,,,,,-0.5777,1.0628499150276185,-1.1156466666666667,2.100617660674437,-0.8466733333333334,0.7614588303372185,Neutral,Uncertain,Uncertain,Neutral,Neutral,0.4801155740102469,0.1793538001332066,0.6707008473688556,0.69161,8.34626,4.666905809347836,4.518935,2.679257904673918,Uncertain,Uncertain,Destabilizing,Uncertain,9.902647202787074,1.0423622781579525,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.3909,0.7543,-22.239,-6.70333838902764,0.4298440117530282,Uncertain,0.8782,pathogenic,-3.674,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H233Q,NP_000537:p.His233Gln,"hg38,17:g.7674264G>C, hg38,17:g.7674264G>T",,,0.669,"COSMIC,saturation_mutlist",,,,,,,,-0.12378,0.5904954648017884,0.18877333333333335,0.7315087016230947,0.032496666666666674,0.30386435081154733,Neutral,Neutral,Neutral,Neutral,Neutral,0.10034348228205102,0.4105637114450759,0.09568996636123142,-0.28537,0.45181333333333334,0.5800464355006539,0.08322166666666667,0.14733821775032696,Neutral,Neutral,Neutral,Neutral,0.26779781606444986,0.19102403679102722,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.1959,0.7543,-22.239,-5.6517055286347,0.8071482882056782,Pathogenic,0.9481,pathogenic,-3.682,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H233R,NP_000537:p.His233Arg,"hg19,17:g.7577583T>C, hg38,17:g.7674265T>C",,,0.717,"COSMIC,ClinVar,saturation_mutlist",246388,Conflicting classifications of pathogenicity,1,,,,,-0.32681,0.44502322673797606,-0.25045333333333336,0.27618768855526443,-0.2886316666666667,-0.02531115572236778,Neutral,Neutral,Neutral,Neutral,Neutral,0.14376378977511295,0.15005529854764282,0.13188857010763527,-0.65196,0.57846,0.0662434047086648,-0.036750000000000005,-0.2928582976456676,Neutral,Neutral,Neutral,Neutral,0.4405428371906641,0.12122406517869654,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.264,0.7543,-22.239,-5.39308725596142,0.1607460806607719,Benign,0.9072,pathogenic,-3.534,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H233S,NP_000537:p.His233Ser,,,,,saturation_mutlist,,,,,,,,1.096,0.7256211113929748,,1.0985435920771003,,1.0972717960385503,,Neutral,Neutral,,Neutral,0.15816641338122014,,0.13637355914913074,-0.13514,,1.0922494142829204,,0.4785547071414602,,Neutral,,Neutral,,0.23421059467464928,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.2336,0.7543,-22.239,-4.90369467746375,0.1719755398424981,Benign,0.9307,pathogenic,-3.485,available,https://doi.org/10.1101/2022.10.22.513328 +H233T,NP_000537:p.His233Thr,,,,,saturation_mutlist,,,,,,,,1.05309,0.7619553160667419,,0.9144583461983468,,0.9837741730991734,,Neutral,Neutral,,Neutral,0.2941965147982081,,0.1337337302049927,0.29475,,1.0322135263436278,,0.663481763171814,,Neutral,,Neutral,,0.15055866313857064,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.2784,0.7543,-22.239,-4.96568135487633,0.5821690695464069,Uncertain,0.9712,pathogenic,-3.6,available,https://doi.org/10.1101/2022.10.22.513328 +H233V,NP_000537:p.His233Val,,,,,saturation_mutlist,,,,,,,,0.67549,0.5641985154151916,,0.5179607154287176,,0.5967253577143588,,Neutral,Neutral,,Neutral,0.3186114825863623,,0.015558952739372077,-0.30016,,0.4903971201114752,,0.0951185600557376,,Neutral,,Neutral,,0.35757041633783565,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.2703,0.7543,-22.239,-3.74262829021983,0.6186441012884615,Uncertain,0.9371,pathogenic,-3.626,available,https://doi.org/10.1101/2022.10.22.513328 +H233W,NP_000537:p.His233Trp,,,,,saturation_mutlist,,,,,,,,-0.78315,0.1286336088180542,,-0.600016816858788,,-0.691583408429394,,Neutral,Neutral,,Neutral,0.1384115314218398,,0.14007612301841055,-0.12672,,-0.4230134265712011,,-0.27486671328560053,,Neutral,,Neutral,,0.14431888847758478,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.2655,0.7543,-22.239,-4.51441976804299,0.789039925514924,Pathogenic,0.8275,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328 +H233Y,NP_000537:p.His233Tyr,"hg19,17:g.7577584G>A, hg38,17:g.7674266G>A",,,0.690,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-1.01875,-0.046639287471771235,-0.6551033333333334,-0.30700998870345975,-0.8369266666666667,-0.6628799943517298,Neutral,Neutral,Neutral,Neutral,Neutral,0.12207029006081366,0.3401684753504096,0.1478497617856787,-1.00631,-0.6730166666666667,-0.08819138285181101,-0.8396633333333334,-0.5472506914259055,Neutral,Neutral,Neutral,Neutral,0.231142389785075,0.2722296924450162,33.344,3.249,29.84,9.338,,False,33.344,,neutral,neutral,neutral,,False,29.84,,neutral,neutral,neutral,uncertain,,-0.1995,0.7543,-22.239,-1.78984626143471,0.040894694442997,Benign,0.4592,ambiguous,-3.673,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234A,NP_000537:p.Tyr234Ala,,,,,saturation_mutlist,,,,,,,,4.20529,1.522721257209778,,3.5887278790801194,,3.8970089395400596,,Destabilizing,Uncertain,,Destabilizing,0.2863844690837529,,0.42801072455446065,-0.06221,,3.602169130770015,,1.7699795653850077,,Uncertain,,Neutral,,0.3059935274499801,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.3946,0.6244,-22.2332,-5.30051108287355,0.8131356259477241,Pathogenic,0.9901,pathogenic,-4.416,available,https://doi.org/10.1101/2022.10.22.513328 +Y234C,NP_000537:p.Tyr234Cys,"hg19,17:g.7577580T>C, hg19,17:g.7674262T>C, hg38,17:g.7674262T>C",,3.9764593606e-06,0.945,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127820,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,3.78509,0.5252915239334106,4.490023333333333,3.8417029091348294,4.137556666666667,3.813396454567415,Destabilizing,Destabilizing,Neutral,Destabilizing,Destabilizing,0.2034110670812979,0.1646137785511555,0.34934633241522384,-0.78565,3.7377566666666673,3.5057648760068445,1.4760533333333337,1.3600574380034223,Uncertain,Uncertain,Neutral,Neutral,0.5963092127598082,0.3708490074574019,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.3652,0.6244,-22.2332,-6.44662477801322,0.8434517422407979,Pathogenic,0.8,pathogenic,-4.003,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234D,NP_000537:p.Tyr234Asp,"hg19,17:g.7577581A>C, hg19,17:g.7674263A>C, hg38,17:g.7674263A>C",,,0.876,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",219759,Pathogenic/Likely pathogenic,2,,,,,5.33498,2.47607647895813,5.468933333333332,4.65579080543122,5.401956666666666,4.99538540271561,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.24249567598774532,0.015170116091257044,0.3092985595416991,0.82246,4.3866233333333335,4.450327087109333,2.604541666666667,2.636393543554666,Uncertain,Uncertain,Uncertain,Uncertain,0.6829701955592368,0.36494970117819686,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.4088,0.6244,-22.2332,-6.80960627818916,0.7285842565188764,Pathogenic,0.9975,pathogenic,-4.619,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234E,NP_000537:p.Tyr234Glu,,,,,saturation_mutlist,,,,,,,,3.29687,2.1566315698623657,,4.231678379196145,,3.7642741895980727,,Destabilizing,Destabilizing,,Destabilizing,0.23074567591721412,,0.413266396133422,-0.4601,,4.08532423446093,,1.8126121172304648,,Uncertain,,Neutral,,0.404357638201849,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.4375,0.6244,-22.2332,-6.80960627818916,0.7890939240712694,Pathogenic,0.9991,pathogenic,-4.631,available,https://doi.org/10.1101/2022.10.22.513328 +Y234F,NP_000537:p.Tyr234Phe,"hg38,17:g.7674262T>A",,,0.686,"COSMIC,saturation_mutlist",,,,,,,,-0.54236,-0.6263150739669799,-0.23355666666666666,0.49199686475161303,-0.3879583333333333,-0.025181567624193463,Neutral,Neutral,Neutral,Neutral,Neutral,0.29371869928241984,0.11044161695464058,0.11662397240252183,-1.51966,-0.3631533333333333,1.0950950096708898,-0.9414066666666666,-0.2122824951645551,Neutral,Neutral,Neutral,Neutral,0.12498654069761093,0.43168452063305945,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,uncertain,,-0.15,0.6244,-6.1381,-1.56308951962019,8.983210709395668e-06,Benign,0.0991,benign,-3.104,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234G,NP_000537:p.Tyr234Gly,,,,,saturation_mutlist,,,,,,,,5.39906,2.0775132036209105,,5.351871633172002,,5.375465816586001,,Destabilizing,Destabilizing,,Destabilizing,0.339533041259947,,0.20435835854824355,0.96095,,5.31226340952863,,3.136606704764315,,Uncertain,,Destabilizing,,0.4926505130722566,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.4651,0.6244,-22.2332,-6.80960627818916,0.7217997233964804,Pathogenic,0.9754,pathogenic,-4.374,available,https://doi.org/10.1101/2022.10.22.513328 +Y234H,NP_000537:p.Tyr234His,"hg19,17:g.7577581A>G, hg19,17:g.7674263A>G, hg38,17:g.7674263A>G",,,0.890,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376691,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,2.65294,1.6007305002212524,2.938663333333333,2.5846515776032244,2.7958016666666667,2.618795788801612,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.14796485618638822,0.08867249642489053,0.23498696109792702,0.34327,2.36304,2.7555090456362454,1.3531549999999999,1.5493895228181227,Uncertain,Uncertain,Neutral,Neutral,0.16276921351000828,0.1781548088626745,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.3023,0.6244,-22.2332,-4.09950607784027,0.764616884486288,Pathogenic,0.9891,pathogenic,-4.166,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234I,NP_000537:p.Tyr234Ile,,,,,saturation_mutlist,,,,,,,,1.95779,0.0008154106140136955,,2.2234772612354274,,2.0906336306177136,,Uncertain,Neutral,,Uncertain,0.29550889961933763,,0.49871438632608855,-2.00799,,1.5781111534915102,,-0.21493942325424487,,Uncertain,,Neutral,,0.1865830325173271,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.3388,0.6244,-8.9453,-3.29952705774347,0.0375445911581829,Benign,0.8428,pathogenic,-3.946,available,https://doi.org/10.1101/2022.10.22.513328 +Y234K,NP_000537:p.Tyr234Lys,,,,,saturation_mutlist,,,,,,,,3.62651,1.9158089447021485,,4.16617003049351,,3.8963400152467553,,Destabilizing,Uncertain,,Destabilizing,0.23602512880816467,,0.4960118142007048,0.72443,,4.154877624706202,,2.439653812353101,,Uncertain,,Uncertain,,0.6752161025925304,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.4628,0.6244,-22.2332,-6.80960627818916,0.7901960575415723,Pathogenic,0.9989,pathogenic,-4.634,available,https://doi.org/10.1101/2022.10.22.513328 +Y234L,NP_000537:p.Tyr234Leu,,,,,saturation_mutlist,,,,,,,,0.76698,-0.15890495777130123,,1.4983197039120555,,1.1326498519560277,,Neutral,Neutral,,Neutral,0.34951303628936886,,0.33489159856284484,-2.95455,,1.1416424833532668,,-0.9064537583233665,,Uncertain,,Neutral,,0.25831513377283816,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.2865,0.6244,-3.1906,-2.74410102072675,3.631787118428928e-06,Benign,0.3996,ambiguous,-3.504,available,https://doi.org/10.1101/2022.10.22.513328 +Y234M,NP_000537:p.Tyr234Met,,,,,saturation_mutlist,,,,,,,,0.67936,0.20130063056945802,,2.0525641813589046,,1.3659620906794523,,Uncertain,Neutral,,Neutral,0.33835002553714366,,0.23481639131647802,-3.0964,,1.795363281161982,,-0.650518359419009,,Uncertain,,Neutral,,0.22589798179376552,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.3358,0.6244,-22.2332,-4.98663984119722,0.7771411342636707,Pathogenic,0.8706,pathogenic,-4.244,available,https://doi.org/10.1101/2022.10.22.513328 +Y234N,NP_000537:p.Tyr234Asn,"hg19,17:g.7577581A>T, hg19,17:g.7674263A>T, hg38,17:g.7674263A>T, hg38,17:g.7674263_7674264delinsTA",,,0.941,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376692,Pathogenic/Likely pathogenic,2,,,,,3.83975,2.038312530517578,4.354306666666666,3.5272232914277715,4.097028333333333,3.6834866457138857,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.23962200102689624,0.12980452851199858,0.27384680648180626,-0.4005,2.64456,3.22634265164695,1.1220299999999999,1.412921325823475,Uncertain,Uncertain,Neutral,Neutral,0.6220416378882258,0.21146986647201094,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.3878,0.6244,-22.2332,-6.80960627818916,0.7878926811120062,Pathogenic,0.9909,pathogenic,-4.415,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234P,NP_000537:p.Tyr234Pro,,,,,saturation_mutlist,,,,,,,,5.52671,2.0136175775527954,,7.146162670313035,,6.336436335156517,,Destabilizing,Destabilizing,,Destabilizing,0.2977599698267774,,0.7330712717777496,2.3196,,7.581826293289278,,4.950713146644639,,Uncertain,,Destabilizing,,2.0093756729450583,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.5188,0.6244,-22.2332,-6.80960627818916,0.8441278531417278,Pathogenic,0.998,pathogenic,-4.697,available,https://doi.org/10.1101/2022.10.22.513328 +Y234Q,NP_000537:p.Tyr234Gln,"hg19,17:g.7577579_7577581delinsCTG, hg38,17:g.7674261_7674263delinsCTG",,,,"ClinVar,saturation_mutlist",2751786,Uncertain significance,1,,,,,3.17341,1.8502722930908204,3.7096366666666665,3.412257397341166,3.4415233333333335,3.292833698670583,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.23058888668027397,0.04733457251899034,0.3790973098754531,-1.04434,2.9772133333333333,3.136292003149135,0.9664366666666666,1.0459760015745674,Uncertain,Uncertain,Neutral,Neutral,0.6503888788682933,0.29553100201930466,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.4123,0.6244,-22.2332,-6.80960627818916,0.8267703896137975,Pathogenic,0.9986,pathogenic,-4.474,available,https://doi.org/10.1101/2022.10.22.513328 +Y234R,NP_000537:p.Tyr234Arg,"hg38,17:g.7674262_7674263delinsCG",,,,"COSMIC,saturation_mutlist",,,,,,,,3.73384,1.9289533376693726,3.815986666666667,3.330088343288906,3.774913333333333,3.5319641716444528,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.23572936909080056,0.22810643514718223,0.3921242344869159,1.89796,3.191046666666667,3.2623410177153027,2.5445033333333336,2.5801505088576513,Uncertain,Uncertain,Uncertain,Uncertain,0.6554291782912595,0.5800631609678218,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.4581,0.6244,-22.2332,-6.80960627818916,0.4442572620894961,Uncertain,0.997,pathogenic,-4.295,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234S,NP_000537:p.Tyr234Ser,"hg19,17:g.7577580T>G, hg19,17:g.7674262T>G, hg38,17:g.7674262T>G",,,0.936,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376690,Conflicting classifications of pathogenicity,1,,,,,4.79398,1.8689454126358032,5.64966,4.549530128266764,5.22182,4.671755064133382,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.2548967080633716,0.2852906405755365,0.2506892981058113,0.018,4.497846666666667,4.3488362581629465,2.2579233333333333,2.183418129081473,Uncertain,Uncertain,Uncertain,Uncertain,0.6197174995825832,0.4199994824167519,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.3993,0.6244,-22.2332,-6.44662477801322,0.8155826251834095,Pathogenic,0.9852,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234T,NP_000537:p.Tyr234Thr,,,,,saturation_mutlist,,,,,,,,4.34318,1.568694496154785,,3.608999472132402,,3.976089736066201,,Destabilizing,Uncertain,,Destabilizing,0.27028002344793134,,0.48168895766705006,-0.83352,,3.329529988251585,,1.2480049941257925,,Uncertain,,Neutral,,0.39932278833700297,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.4179,0.6244,-22.2332,-6.44662477801322,0.4990018039161688,Uncertain,0.9894,pathogenic,-4.292,available,https://doi.org/10.1101/2022.10.22.513328 +Y234V,NP_000537:p.Tyr234Val,,,,,saturation_mutlist,,,,,,,,2.94236,0.38815754890441895,,2.423780531657632,,2.6830702658288157,,Uncertain,Neutral,,Uncertain,0.25751034641138504,,0.43586789249335267,-1.55525,,1.9908152900222351,,0.21778264501111755,,Neutral,,Neutral,,0.3193679243951632,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.3962,0.6244,-22.2332,-4.98663984119722,0.7904365545728758,Pathogenic,0.8024,pathogenic,-4.04,available,https://doi.org/10.1101/2022.10.22.513328 +Y234W,NP_000537:p.Tyr234Trp,,,,,saturation_mutlist,,,,,,,,-0.2753,-0.06224444389343261,,0.9938456948232824,,0.3592728474116412,,Neutral,Neutral,,Neutral,0.15124674881962955,,0.2266923708486395,2.3298,,1.8374211465083639,,2.083610573254182,,Uncertain,,Uncertain,,0.4798440859820124,0.08,0.231,3.21,2.034,,False,0.08,,uncertain,,,,False,3.21,,uncertain,,,damaging,,-0.3121,0.6244,-22.2332,-4.09950607784027,0.8186385897816553,Pathogenic,0.8383,pathogenic,-4.294,available,https://doi.org/10.1101/2022.10.22.513328 +N235A,NP_000537:p.Asn235Ala,,,,,saturation_mutlist,,,,,,,,0.28899,0.10955121994018555,,0.6435384092435005,,0.4662642046217502,,Neutral,Neutral,,Neutral,0.3471362364554545,,0.19058140455340786,-0.99784,,0.7738177154009523,,-0.1120111422995238,,Neutral,,Neutral,,0.3619623244480876,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.2785,0.5476,-22.239,-3.89285589000458,0.3923519926420194,Uncertain,0.6884,pathogenic,-3.843,available,https://doi.org/10.1101/2022.10.22.513328 +N235C,NP_000537:p.Asn235Cys,,,,,saturation_mutlist,,,,,,,,0.13494,-0.5147520184516907,,0.9576103754687318,,0.5462751877343659,,Neutral,Neutral,,Neutral,0.22174403288391498,,0.28226110989131553,-0.74526,,1.1671451814252114,,0.21094259071260568,,Neutral,,Neutral,,0.14295251318492933,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.3284,0.5476,-22.239,-3.9275215297451,0.7251642937963347,Pathogenic,0.4606,ambiguous,-4.094,available,https://doi.org/10.1101/2022.10.22.513328 +N235D,NP_000537:p.Asn235Asp,"hg19,17:g.7577578T>C, hg38,17:g.7674260T>C",,,0.912,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",919580,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,2.37507,0.639793701171875,1.6520366666666666,1.7582689425861222,2.0135533333333333,2.066669471293061,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.3070928955835116,0.5707809971336544,0.2731559303832144,0.90246,1.5846933333333333,1.3733719613062225,1.2435766666666668,1.1379159806531112,Neutral,Neutral,Neutral,Neutral,0.2886251369664273,0.423043418243613,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.2817,0.5476,-22.239,-4.00222966243389,0.8573187375776279,Pathogenic,0.8126,pathogenic,-4.25,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235E,NP_000537:p.Asn235Glu,,,,,saturation_mutlist,,,,,,,,1.27481,0.08475456476211547,,1.1264055953987677,,1.2006077976993839,,Neutral,Neutral,,Neutral,0.4566720104374232,,0.162599292208178,0.59989,,1.259086263125987,,0.9294881315629935,,Neutral,,Neutral,,0.4735450670479082,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.3088,0.5476,-22.239,-3.51635481758845,0.3730297505020503,Uncertain,0.959,pathogenic,-4.027,available,https://doi.org/10.1101/2022.10.22.513328 +N235F,NP_000537:p.Asn235Phe,,,,,saturation_mutlist,,,,,,,,3.43362,-0.018921300172805786,,-0.12816860422524465,,1.6527256978873777,,Uncertain,Neutral,,Neutral,0.3135846910367185,,0.2614113712062487,2.28937,,-0.10870883978917815,,1.0903305801054108,,Uncertain,,Neutral,,0.750584056934799,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.3357,0.5476,-22.239,-5.71782841479094,0.5936106531669454,Uncertain,0.9717,pathogenic,-4.19,available,https://doi.org/10.1101/2022.10.22.513328 +N235G,NP_000537:p.Asn235Gly,,,,,saturation_mutlist,,,,,,,,1.68832,0.6664001768827439,,2.267103185331143,,1.9777115926655715,,Uncertain,Neutral,,Neutral,0.3921858275540147,,0.27922592321436907,-0.66381,,2.252757214951013,,0.7944736074755064,,Uncertain,,Neutral,,0.4078285521195022,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.3093,0.5476,-22.239,-6.63170971104971,0.6933695741011554,Pathogenic,0.7788,pathogenic,-4.206,available,https://doi.org/10.1101/2022.10.22.513328 +N235H,NP_000537:p.Asn235His,"hg38,17:g.7674260T>G",,,0.902,"COSMIC,saturation_mutlist",,,,,,,,3.11105,-0.1316189646720886,0.24263,0.514300167826265,1.67684,1.8126750839131325,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.15587720407349787,0.3459996879574701,0.1995116472390471,2.90847,1.1900233333333332,0.3570036973525115,2.0492466666666664,1.6327368486762557,Uncertain,Uncertain,Uncertain,Neutral,0.3026642412898417,0.6550622968338802,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.2835,0.5476,-22.239,-4.59891063784102,0.6609007583480746,Uncertain,0.3915,ambiguous,-3.822,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235I,NP_000537:p.Asn235Ile,"hg19,17:g.7577577T>A, hg38,17:g.7674259T>A",,3.9763961127e-06,0.886,"COSMIC,ClinVar,saturation_mutlist",3673072,Uncertain significance,2,,,,,-0.01166,-0.4044971215724945,-2.031746666666667,-0.3207324177670738,-1.0217033333333334,-0.1661962088835369,Uncertain,Neutral,Neutral,Neutral,Neutral,0.5585019822043151,0.44873376348218874,0.4068759035987842,-0.795,-1.2679133333333334,0.024192986919910175,-1.0314566666666667,-0.38540350654004496,Neutral,Neutral,Neutral,Neutral,0.5325144045834713,0.3283364997205846,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.3288,0.5476,-22.239,-5.06640171466846,0.4750299755105782,Uncertain,0.8491,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235K,NP_000537:p.Asn235Lys,"hg19,17:g.7577576G>C",,,0.565,"cBioPortal,saturation_mutlist",,,,,,,,-0.63965,-0.2597953486442566,0.5646266666666667,0.8528491170449204,-0.037511666666666665,0.10659955852246017,Neutral,Neutral,Neutral,Neutral,Neutral,0.2085638854902282,1.1264971185148331,0.2742348522327231,-0.32263,0.28356,1.2188930863980947,-0.019534999999999997,0.44813154319904736,Neutral,Neutral,Neutral,Neutral,0.32435562592109707,0.5783452601402523,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.1977,0.5476,-5.7813,-1.52572489034109,0.0027619354383635,Benign,0.8166,pathogenic,-3.605,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235L,NP_000537:p.Asn235Leu,,,,,saturation_mutlist,,,,,,,,-1.50418,-0.21018248796463013,,-0.7079452775812051,,-1.1060626387906025,,Neutral,Neutral,,Neutral,0.3428391629140813,,0.23619868415429007,-1.33711,,-0.2648918886312717,,-0.8010009443156358,,Neutral,,Neutral,,0.21418605029113816,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.3352,0.5476,-22.239,-5.62147723552449,0.7907897634769809,Pathogenic,0.7526,pathogenic,-4.049,available,https://doi.org/10.1101/2022.10.22.513328 +N235M,NP_000537:p.Asn235Met,"hg38,17:g.7674258_7674259delinsCA",,,,"COSMIC,saturation_mutlist",,,,,,,,-1.25856,-0.303396532535553,-1.0734733333333333,-0.14657896887837527,-1.1660166666666667,-0.7025694844391875,Neutral,Neutral,Neutral,Neutral,Neutral,0.3139947618169093,0.27826507390536015,0.2502917115270811,-1.24226,-0.33424000000000004,0.3647882324565718,-0.78825,-0.438735883771714,Neutral,Neutral,Neutral,Neutral,0.2205530158487977,0.36509577617277866,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.2894,0.5476,-22.239,-5.96096504736547,0.7235454533082708,Pathogenic,0.8714,pathogenic,-4.15,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235P,NP_000537:p.Asn235Pro,,,,,saturation_mutlist,,,,,,,,3.3183,1.8467415475845337,,5.0188091016952106,,4.168554550847605,,Destabilizing,Uncertain,,Destabilizing,0.3435176115651071,,2.0280063331097193,2.18212,,5.156820064959088,,3.669470032479544,,Uncertain,,Destabilizing,,1.2152499220729285,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.4441,0.5476,-22.239,-6.63170971104971,0.8369666341178299,Pathogenic,0.9912,pathogenic,-4.493,available,https://doi.org/10.1101/2022.10.22.513328 +N235Q,NP_000537:p.Asn235Gln,,,,,saturation_mutlist,,,,,,,,-0.08983,-0.47180992007255557,,0.5901697470705656,,0.2501698735352828,,Neutral,Neutral,,Neutral,0.3611137039604746,,0.10261843193547025,0.04622,,0.9642851624025001,,0.50525258120125,,Neutral,,Neutral,,0.3327192852980819,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.2725,0.5476,-22.239,-2.96507093069345,0.1001261408992443,Benign,0.7732,pathogenic,-3.708,available,https://doi.org/10.1101/2022.10.22.513328 +N235R,NP_000537:p.Asn235Arg,,,,,saturation_mutlist,,,,,,,,-0.48363,-0.22560754776000977,,0.29079892307564564,,-0.09641553846217718,,Neutral,Neutral,,Neutral,0.24829322180117452,,0.22008056260628744,0.02733,,0.5540619254844793,,0.29069596274223963,,Neutral,,Neutral,,0.4725908263208377,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.2461,0.5476,-8.9511,-3.30319615207498,0.0187244287318889,Benign,0.7411,pathogenic,-3.716,available,https://doi.org/10.1101/2022.10.22.513328 +N235S,NP_000537:p.Asn235Ser,"hg19,17:g.7577577T>C, hg38,17:g.7674259T>C",0.0003198362438432,0.0001789378250704,0.593,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127821,Benign,3,,,,,0.94815,-0.25966694712638855,0.15521333333333334,1.4456112280817648,0.5516816666666667,1.1968806140408823,Neutral,Neutral,Neutral,Neutral,Neutral,0.3080794919269619,0.5192605374525928,0.36738844531513604,-0.86605,0.79887,1.5094027318627397,-0.03359000000000001,0.32167636593136983,Neutral,Neutral,Neutral,Neutral,0.5945241386184416,0.30520245387833217,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.1536,0.5476,-3.6659,-2.64118094815742,9.891768033379236e-06,Benign,0.1402,benign,-3.258,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235T,NP_000537:p.Asn235Thr,"hg19,17:g.7577577T>G, hg38,17:g.7674259T>G",,,0.872,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.36505,-0.5469939911365509,-0.30782333333333334,0.7327626809242646,0.5286133333333334,1.0489063404621324,Neutral,Neutral,Neutral,Neutral,Neutral,0.4276933255003703,0.46002639781743926,0.4498813169833603,-0.7915,-0.03469,0.9824587041136924,-0.413095,0.09547935205684621,Neutral,Neutral,Neutral,Neutral,0.4631887169034525,0.26015775819865605,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.298,0.5476,-22.239,-3.17005902451428,0.2394262916077165,Benign,0.5234,ambiguous,-3.682,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235V,NP_000537:p.Asn235Val,,,,,saturation_mutlist,,,,,,,,-0.13798,-0.5176718235015869,,-0.2219518462722346,,-0.1799659231361173,,Neutral,Neutral,,Neutral,0.4794682098559522,,0.4110996674293779,-1.18517,,-0.07863789186707122,,-0.6319039459335356,,Neutral,,Neutral,,0.36855763885444087,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.3221,0.5476,-22.239,-5.63693704446803,0.6741832128608591,Uncertain,0.7546,pathogenic,-4.002,available,https://doi.org/10.1101/2022.10.22.513328 +N235W,NP_000537:p.Asn235Trp,,,,,saturation_mutlist,,,,,,,,3.77225,0.11372302055358886,,-0.051575263230682254,,1.860337368384659,,Uncertain,Neutral,,Neutral,0.3827879806396868,,0.21473957231067062,3.52631,,-0.2871134566325548,,1.6195982716837227,,Uncertain,,Neutral,,0.7879020279168469,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.3408,0.5476,-22.239,-5.71782841479094,0.8542773095716907,Pathogenic,0.9843,pathogenic,-4.598,available,https://doi.org/10.1101/2022.10.22.513328 +N235Y,NP_000537:p.Asn235Tyr,"hg19,17:g.7577578T>A, hg38,17:g.7674260T>A",,,0.932,"COSMIC,ClinVar,saturation_mutlist",188206,Uncertain significance,1,,,,,4.85835,0.07910092890262604,0.6899099999999999,0.3606986571316499,2.77413,2.6095243285658247,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.36002270539510844,1.3754492754248218,0.3250975961222367,3.37253,0.42710000000000004,0.05367370690700098,1.8998149999999998,1.7131018534535003,Uncertain,Uncertain,Neutral,Neutral,0.8759639134119623,0.8082792613476127,6.317,2.733,7.67,5.146,,False,6.317,,neutral,neutral,neutral,,False,7.67,,neutral,neutral,neutral,uncertain,,-0.3192,0.5476,-22.239,-5.15056092513449,0.6774580667997819,Uncertain,0.7572,pathogenic,-4.091,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236A,NP_000537:p.Tyr236Ala,,,,,saturation_mutlist,,,,,,,,5.48558,2.5174621152877807,,3.459524495001974,,4.472552247500987,,Destabilizing,Destabilizing,,Destabilizing,0.3773882243569862,,0.3684811884812652,-0.50728,,3.4801778229705564,,1.4864489114852781,,Uncertain,,Neutral,,0.5128104583370414,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.3815,0.7671,-22.2419,-6.69585764268672,0.6727282662254873,Uncertain,0.9966,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328 +Y236C,NP_000537:p.Tyr236Cys,"hg19,17:g.7577574T>C, hg19,17:g.7674256T>C, hg38,17:g.7674256T>C",,,0.811,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376693,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,4.56608,1.5207295083999635,5.134013333333333,3.4562034652787794,4.850046666666667,4.0111417326393894,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.3767057949180221,0.24052323468268552,0.39598102324915,-0.8275,4.585260000000001,3.6519353537701136,1.8788800000000003,1.4122176768850567,Uncertain,Uncertain,Neutral,Neutral,0.048044634108989556,0.4926782816368389,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.3521,0.7671,-22.2419,-6.69585764268672,0.4349196484452341,Uncertain,0.9599,pathogenic,-3.774,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236D,NP_000537:p.Tyr236Asp,"hg19,17:g.7577575A>C, hg19,17:g.7674257A>C, hg38,17:g.7674257A>C",,,0.845,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142183,Conflicting classifications of pathogenicity,1,,,,,5.63079,3.025812864303589,5.846143333333334,4.019479750329177,5.7384666666666675,4.825134875164588,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.28692745442498174,0.3698916212742441,0.5794420738746959,1.09188,5.39252,4.446074695543456,3.2422,2.768977347771728,Uncertain,Uncertain,Destabilizing,Uncertain,0.05390058688610604,0.5801684264897677,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.3957,0.7671,-22.2419,-6.69585764268672,0.1483324630442684,Benign,0.9936,pathogenic,-4.28,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236E,NP_000537:p.Tyr236Glu,,,,,saturation_mutlist,,,,,,,,5.24017,2.6907931423187255,,3.696937781382008,,4.468553890691004,,Destabilizing,Destabilizing,,Destabilizing,0.2723461474299219,,0.5330251849038448,0.48341,,4.052201352068727,,2.2678056760343637,,Uncertain,,Uncertain,,0.44360494432569064,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.4244,0.7671,-22.2419,-6.69585764268672,0.6747380281501533,Uncertain,0.9993,pathogenic,-4.439,available,https://doi.org/10.1101/2022.10.22.513328 +Y236F,NP_000537:p.Tyr236Phe,"hg19,17:g.7577574T>A, hg38,17:g.7674256T>A",,,0.468,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.52817,0.2900228214263916,0.5482966666666668,-0.07370078661221595,0.5382333333333333,0.22723460669389203,Neutral,Neutral,Neutral,Neutral,Neutral,0.20590233463559182,0.01209563098349518,0.22306502745888201,-0.59349,-0.005556666666666672,-0.320157031421483,-0.2995233333333333,-0.4568235157107415,Neutral,Neutral,Neutral,Neutral,0.3767849767292864,0.2709142775638087,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,uncertain,,-0.1074,0.7671,-0.3655,-0.344773940656653,7.666419774018076e-13,Benign,0.0654,benign,-2.694,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236G,NP_000537:p.Tyr236Gly,,,,,saturation_mutlist,,,,,,,,6.58908,2.896205015182495,,5.057047591007788,,5.823063795503894,,Destabilizing,Destabilizing,,Destabilizing,0.25153397591599713,,0.5022306553760407,0.15276,,5.190273231097334,,2.6715166155486667,,Uncertain,,Uncertain,,0.4084778472320641,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.452,0.7671,-22.2419,-6.69585764268672,0.6086398998221857,Uncertain,0.9931,pathogenic,-4.362,available,https://doi.org/10.1101/2022.10.22.513328 +Y236H,NP_000537:p.Tyr236His,"hg19,17:g.7577575A>G, hg19,17:g.7674257A>G, hg38,17:g.7674257A>G",,,0.772,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",216469,Pathogenic/Likely pathogenic,2,,,,,3.76409,1.9392403364181519,3.549886666666667,1.8053879967815742,3.6569883333333335,2.784738998390787,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,0.22066786232145968,0.2815283859380594,0.1836549971401842,1.03143,2.9595233333333333,1.8244710365114243,1.9954766666666668,1.4279505182557122,Uncertain,Neutral,Neutral,Neutral,0.33792985527900454,0.4140221844648605,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.2892,0.7671,-22.2419,-4.01811152617371,0.5281329031450582,Uncertain,0.982,pathogenic,-4.041,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236I,NP_000537:p.Tyr236Ile,,,,,saturation_mutlist,,,,,,,,2.58686,1.0811236238479613,,1.9020072163434463,,2.244433608171723,,Uncertain,Uncertain,,Uncertain,0.6279501597420792,,0.23039560134983164,-0.83693,,1.7279390969658792,,0.44550454848293963,,Neutral,,Neutral,,0.6207090433255716,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.3935,0.7671,-22.2419,-6.24692007678165,0.6460567811563991,Uncertain,0.9786,pathogenic,-3.805,available,https://doi.org/10.1101/2022.10.22.513328 +Y236K,NP_000537:p.Tyr236Lys,,,,,saturation_mutlist,,,,,,,,4.02486,2.58730188369751,,4.302334957343409,,4.163597478671704,,Destabilizing,Destabilizing,,Destabilizing,0.31752855549823794,,0.4478875609701611,0.71749,,4.3441807018943495,,2.5308353509471746,,Uncertain,,Uncertain,,0.4946156780676596,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.4497,0.7671,-22.2419,-6.69585764268672,0.5983956495817317,Uncertain,0.9993,pathogenic,-4.474,available,https://doi.org/10.1101/2022.10.22.513328 +Y236L,NP_000537:p.Tyr236Leu,"hg38,17:g.7674255_7674256delinsTA",,,,"COSMIC,saturation_mutlist",,,,,,,,1.87454,1.2475951290130616,2.8943333333333334,1.1507780098860712,2.3844366666666668,1.5126590049430355,Uncertain,Neutral,Uncertain,Uncertain,Neutral,0.526498876360573,0.07699985901863002,0.14859430837659068,-2.09154,1.8994366666666667,1.3223423044963478,-0.09605166666666676,-0.3845988477518262,Uncertain,Uncertain,Neutral,Neutral,0.14994744197736606,0.5529241595089112,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.3706,0.7671,-22.2419,-4.44282781099961,0.0199162357938249,Benign,0.9639,pathogenic,-3.47,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236M,NP_000537:p.Tyr236Met,,,,,saturation_mutlist,,,,,,,,1.66117,1.524026107788086,,1.5649922358980382,,1.6130811179490192,,Neutral,Uncertain,,Neutral,0.4538580603792289,,0.32669972769288713,-2.69039,,1.7757237892175641,,-0.45733310539121785,,Uncertain,,Neutral,,0.5082935135727366,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.3227,0.7671,-22.2419,-6.24692007678165,0.6627166621305067,Uncertain,0.986,pathogenic,-4.016,available,https://doi.org/10.1101/2022.10.22.513328 +Y236N,NP_000537:p.Tyr236Asn,"hg19,17:g.7577575A>T, hg19,17:g.7674257A>T, hg38,17:g.7674257A>T",,,0.837,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376694,Conflicting classifications of pathogenicity,1,,,,,4.87293,2.6844382762908934,4.871543333333334,3.1329619719464006,4.872236666666668,4.0029459859732,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.2764506417617327,0.5054152165848942,0.4644431246692917,0.41014,4.264623333333333,3.3292518904090507,2.3373816666666665,1.8696959452045254,Uncertain,Uncertain,Uncertain,Neutral,0.5073370173322221,0.5290058742013383,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.3747,0.7671,-22.2419,-6.69585764268672,0.7727196034305899,Pathogenic,0.9869,pathogenic,-4.263,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236P,NP_000537:p.Tyr236Pro,,,,,saturation_mutlist,,,,,,,,4.27247,2.5867635679244994,,5.30879492880283,,4.7906324644014155,,Destabilizing,Destabilizing,,Destabilizing,0.2561516775332623,,0.291357302298072,-0.09762,,5.8946687506734206,,2.8985243753367103,,Uncertain,,Uncertain,,0.7739193016754157,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.5057,0.7671,-22.2419,-6.69585764268672,0.6114516452143864,Uncertain,0.9986,pathogenic,-4.382,available,https://doi.org/10.1101/2022.10.22.513328 +Y236Q,NP_000537:p.Tyr236Gln,,,,,saturation_mutlist,,,,,,,,4.56268,2.5994565868377686,,3.097809943554331,,3.830244971777166,,Destabilizing,Destabilizing,,Destabilizing,0.29717850092639597,,0.4298676346311823,-0.10124,,3.2671172671764417,,1.582938633588221,,Uncertain,,Neutral,,0.5952281874686157,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.3992,0.7671,-22.2419,-6.69585764268672,0.6837838608605176,Pathogenic,0.9991,pathogenic,-4.351,available,https://doi.org/10.1101/2022.10.22.513328 +Y236R,NP_000537:p.Tyr236Arg,,,,,saturation_mutlist,,,,,,,,4.47067,2.5063316774368287,,3.199504907130661,,3.8350874535653308,,Destabilizing,Destabilizing,,Destabilizing,0.27340349479651466,,0.39404898146551676,1.94259,,3.272500875329675,,2.6075454376648377,,Uncertain,,Uncertain,,0.43590778680009673,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.445,0.7671,-22.2419,-6.69585764268672,0.7229686200231711,Pathogenic,0.9982,pathogenic,-4.39,available,https://doi.org/10.1101/2022.10.22.513328 +Y236S,NP_000537:p.Tyr236Ser,"hg19,17:g.7577573_7577574delinsAG, hg19,17:g.7577574T>G, hg19,17:g.7674256T>G, hg38,17:g.7674255_7674256delinsAG, hg38,17:g.7674256T>G",,,0.780,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182966,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,6.0779,2.644802837371826,6.18753,4.082500748746582,6.132714999999999,5.080200374373291,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.2878841128416061,0.4084267623454665,0.521870693711872,0.368,5.850903333333334,4.203261617548907,3.109451666666667,2.2856308087744535,Uncertain,Uncertain,Destabilizing,Uncertain,0.2528447790421803,0.5252235216877427,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.3862,0.7671,-22.2419,-6.69585764268672,0.6671190041671116,Uncertain,0.9891,pathogenic,-4.063,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236T,NP_000537:p.Tyr236Thr,,,,,saturation_mutlist,,,,,,,,4.80365,2.3651876211166383,,3.3358060287148663,,4.069728014357433,,Destabilizing,Destabilizing,,Destabilizing,0.32230751681462383,,0.34987219666897584,0.37457,,3.270840966908835,,1.8227054834544174,,Uncertain,,Neutral,,0.596634550479618,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.4048,0.7671,-22.2419,-6.69585764268672,0.6605045967912799,Uncertain,0.9963,pathogenic,-4.331,available,https://doi.org/10.1101/2022.10.22.513328 +Y236V,NP_000537:p.Tyr236Val,,,,,saturation_mutlist,,,,,,,,3.38086,1.4810415363311769,,2.2862780631861535,,2.833569031593077,,Uncertain,Uncertain,,Uncertain,0.5184183681744932,,0.25941150982495176,-0.76077,,2.021056128623109,,0.6301430643115544,,Uncertain,,Neutral,,0.6364105028671365,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.3831,0.7671,-22.2419,-6.24692007678165,0.318476182684569,Benign,0.9677,pathogenic,-3.94,available,https://doi.org/10.1101/2022.10.22.513328 +Y236W,NP_000537:p.Tyr236Trp,,,,,saturation_mutlist,,,,,,,,0.45392,0.20855218410491944,,0.5420072201780594,,0.4979636100890297,,Neutral,Neutral,,Neutral,0.19480158703752484,,0.22003134363398683,2.19268,,0.23556582482212407,,1.2141229124110622,,Uncertain,,Neutral,,0.14263092743960665,0.338,0.402,0.66,0.6,,False,0.338,,uncertain,,,,False,0.66,,uncertain,,,damaging,,-0.299,0.7671,-22.2419,-4.01811152617371,0.7269624582484571,Pathogenic,0.8651,pathogenic,-4.034,available,https://doi.org/10.1101/2022.10.22.513328 +M237A,NP_000537:p.Met237Ala,,,,,saturation_mutlist,,,,,,,,1.25638,1.1362775707244872,,1.4018250616959584,,1.3291025308479791,,Neutral,Uncertain,,Neutral,0.37606190501944897,,0.4226048020505315,0.5614,,1.3556809861174017,,0.9585404930587009,,Neutral,,Neutral,,0.11345239108642077,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.3979,0.042,-22.2419,-6.07174334805245,0.639768245115285,Uncertain,0.9724,pathogenic,-3.974,available,https://doi.org/10.1101/2022.10.22.513328 +M237C,NP_000537:p.Met237Cys,,,,,saturation_mutlist,,,,,,,,1.39372,0.45353532791137696,,1.679134489068,,1.536427244534,,Neutral,Neutral,,Neutral,0.2805505322886951,,0.371185428589869,0.45976,,1.6001481444002732,,1.0299540722001366,,Neutral,,Neutral,,0.08369217885261739,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.4034,0.042,-22.2419,-6.66034877067227,0.6943543867819147,Pathogenic,0.9643,pathogenic,-4.306,available,https://doi.org/10.1101/2022.10.22.513328 +M237D,NP_000537:p.Met237Asp,,,,,saturation_mutlist,,,,,,,,0.91932,0.6787532520294189,,1.6119757561263768,,1.2656478780631883,,Neutral,Neutral,,Neutral,0.5991012249888501,,0.5824783979549462,0.33513,,1.2675979142717495,,0.8013639571358747,,Neutral,,Neutral,,0.19727143194218616,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.5093,0.042,-22.2419,-8.03111563380106,0.8595507782668348,Pathogenic,0.9994,pathogenic,-4.813,available,https://doi.org/10.1101/2022.10.22.513328 +M237E,NP_000537:p.Met237Glu,,,,,saturation_mutlist,,,,,,,,1.15805,0.6133222770690918,,1.273264724533642,,1.215657362266821,,Neutral,Neutral,,Neutral,0.385272026905374,,0.6249237306268244,0.69547,,1.2567674982596053,,0.9761187491298027,,Neutral,,Neutral,,0.12868327869051274,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.4995,0.042,-22.2419,-8.03111563380106,0.868001950514842,Pathogenic,0.9938,pathogenic,-4.658,available,https://doi.org/10.1101/2022.10.22.513328 +M237F,NP_000537:p.Met237Phe,,,,,saturation_mutlist,,,,,,,,1.85652,1.214275975227356,,0.33849598412625254,,1.0975079920631263,,Neutral,Uncertain,,Neutral,0.3252852898304514,,0.5173891294995845,1.2527,,0.334504865714006,,0.7936024328570029,,Neutral,,Neutral,,0.3427196528080961,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.4029,0.042,-22.2419,-6.71087496124933,0.6017076461000541,Uncertain,0.9152,pathogenic,-4.217,available,https://doi.org/10.1101/2022.10.22.513328 +M237G,NP_000537:p.Met237Gly,,,,,saturation_mutlist,,,,,,,,1.68664,1.8836312532424926,,2.4801150791908064,,2.083377539595403,,Uncertain,Uncertain,,Uncertain,0.4514157235512048,,0.5092008515120381,-0.22555,,2.255211888387826,,1.014830944193913,,Uncertain,,Neutral,,0.3022362691398249,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.4787,0.042,-22.2419,-7.37459769635706,0.4173001864604709,Uncertain,0.9862,pathogenic,-4.302,available,https://doi.org/10.1101/2022.10.22.513328 +M237H,NP_000537:p.Met237His,,,,,saturation_mutlist,,,,,,,,2.17564,1.295979653596878,,0.9328857641035718,,1.5542628820517859,,Uncertain,Uncertain,,Neutral,0.41501930448107566,,0.5117239019687941,2.08649,,0.6572028951691412,,1.3718464475845706,,Uncertain,,Neutral,,0.1341491768077339,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.4561,0.042,-22.2419,-7.06518272089547,0.804841478903289,Pathogenic,0.988,pathogenic,-4.4,available,https://doi.org/10.1101/2022.10.22.513328 +M237I,NP_000537:p.Met237Ile,"hg19,17:g.7577570C>A, hg19,17:g.7577570C>G, hg19,17:g.7577570C>T, hg19,17:g.7674252C>A, hg19,17:g.7674252C>G, hg19,17:g.7674252C>T, hg38,17:g.7674252C>A, hg38,17:g.7674252C>G, hg38,17:g.7674252C>T",,3.9763961127e-06,0.923,"cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","1757269, 634770, 142714","Pathogenic/Likely pathogenic, Pathogenic/Likely pathogenic, Pathogenic","2, 2, 3",Oncogenic,1,"Tier I - Strong, Tier II - Potential","1, 1",1.86007,0.6138620924949646,1.3287966666666666,0.07152218644006746,1.5944333333333334,0.9657960932200337,Neutral,Neutral,Neutral,Neutral,Neutral,0.5418331220169775,1.2267351882764086,0.4177597571051163,1.87451,1.6104299999999998,0.43405468894425486,1.74247,1.1542823444721273,Neutral,Neutral,Neutral,Neutral,1.8141770281314884,0.527669207902392,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,uncertain,,-0.2473,0.042,-8.9541,-4.13950426525933,0.6999422663171178,Pathogenic,0.9957,pathogenic,-3.982,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M237K,NP_000537:p.Met237Lys,"hg19,17:g.7577571A>T, hg19,17:g.7674253A>T, hg38,17:g.7674253A>T",,0.0,0.957,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376636,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,1.47475,2.089347743988037,2.7825399999999996,1.6291519057058508,2.1286449999999997,1.5519509528529254,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,0.4925216851463646,1.1548919756698748,0.6636054490161105,0.88088,1.1023800000000001,1.1380433828829215,0.99163,1.0094616914414607,Neutral,Neutral,Neutral,Neutral,0.34834775077021335,0.09710678979786441,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.4604,0.042,-22.2419,-5.85174250580103,0.3879716862452536,Uncertain,0.9612,pathogenic,-4.087,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M237L,NP_000537:p.Met237Leu,"hg19,17:g.7577572T>A, hg19,17:g.7577572T>G, hg19,17:g.7674254T>A, hg38,17:g.7674254T>A, hg38,17:g.7674254T>G",,,0.941,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2774649, 1757126","Uncertain significance, Uncertain significance","1, 1",,,,,-0.17673,0.10386768341064453,0.28220333333333336,-0.28614530471581595,0.05273666666666668,-0.23143765235790797,Neutral,Neutral,Neutral,Neutral,Neutral,0.22923936671455072,0.7535635895456261,0.26641165267632283,0.17254,-0.24308333333333335,0.06619100340254758,-0.03527166666666667,0.11936550170127379,Neutral,Neutral,Neutral,Neutral,0.0970354802235874,0.222321177682225,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,uncertain,,-0.2821,0.042,-22.2419,-3.47470546913856,0.47721334846938,Uncertain,0.8667,pathogenic,-3.779,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M237N,NP_000537:p.Met237Asn,,,,,saturation_mutlist,,,,,,,,1.4374,1.1798807978630066,,1.192758209357641,,1.3150791046788206,,Neutral,Uncertain,,Neutral,0.535246690871092,,0.3620325096164309,0.60536,,0.8374744145277462,,0.7214172072638732,,Neutral,,Neutral,,0.07940458843027036,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.4509,0.042,-22.2419,-8.03111563380106,0.8258743090259,Pathogenic,0.9905,pathogenic,-4.532,available,https://doi.org/10.1101/2022.10.22.513328 +M237P,NP_000537:p.Met237Pro,,,,,saturation_mutlist,,,,,,,,3.8775,2.4169132995605467,,4.407709711730885,,4.142604855865443,,Destabilizing,Destabilizing,,Destabilizing,0.6084011305015514,,1.375864256857457,3.72707,,4.421414091690881,,4.07424204584544,,Destabilizing,,Destabilizing,,1.2328038900897293,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.5688,0.042,-22.2419,-8.03111563380106,0.6702443162098956,Uncertain,0.999,pathogenic,-4.492,available,https://doi.org/10.1101/2022.10.22.513328 +M237Q,NP_000537:p.Met237Gln,,,,,saturation_mutlist,,,,,,,,1.46884,0.8289512705802917,,1.0246697389313033,,1.2467548694656516,,Neutral,Neutral,,Neutral,0.21064168758105853,,0.3339007914948369,0.9071,,1.0530706169171475,,0.9800853084585738,,Neutral,,Neutral,,0.16908232255475877,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.443,0.042,-22.2419,-8.03111563380106,0.8531427398731435,Pathogenic,0.8954,pathogenic,-4.378,available,https://doi.org/10.1101/2022.10.22.513328 +M237R,NP_000537:p.Met237Arg,"hg19,17:g.7577571A>C, hg38,17:g.7674253A>C",,,0.948,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",419524,Uncertain significance,2,,,,,1.84198,1.9899698328971862,2.0195,1.0893185722038718,1.93074,1.465649286101936,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.5076539271976125,0.9747598863651841,0.4942140376090668,1.69514,1.2071399999999999,0.709734960312078,1.45114,1.2024374801560391,Neutral,Neutral,Neutral,Neutral,0.29951562307610374,0.03980342996082795,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.4877,0.042,-22.2419,-6.92978894269953,0.8573582614168085,Pathogenic,0.9494,pathogenic,-4.312,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M237S,NP_000537:p.Met237Ser,,,,,saturation_mutlist,,,,,,,,1.70162,1.0389045238494874,,1.8201912369821338,,1.760905618491067,,Neutral,Uncertain,,Neutral,0.4435226376634043,,0.4738732574705136,0.87185,,1.6841920933359669,,1.2780210466679836,,Neutral,,Neutral,,0.07060918676017423,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.4292,0.042,-22.2419,-6.33030078337074,0.39559399894699,Uncertain,0.9559,pathogenic,-4.101,available,https://doi.org/10.1101/2022.10.22.513328 +M237T,NP_000537:p.Met237Thr,"hg19,17:g.7577571A>G, hg38,17:g.7674253A>G",,,0.948,"COSMIC,ClinVar,saturation_mutlist",481069,Uncertain significance,2,,,,,2.44926,1.0735663819313048,1.6377566666666665,1.2157911507006542,2.0435083333333335,1.8325255753503273,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.39013057469016515,0.8595544486276337,0.5090151816566129,2.12501,1.4806100000000002,1.3111751509424308,1.80281,1.7180925754712155,Uncertain,Uncertain,Neutral,Neutral,0.4388828514155761,0.2276729671387164,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.3012,0.042,-8.9541,-5.97821824318758,0.0253961230689375,Benign,0.9638,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M237V,NP_000537:p.Met237Val,"hg19,17:g.7577572T>C, hg19,17:g.7674254T>C, hg38,17:g.7674254T>C",,,0.937,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182934,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,1.8986,0.7026956105232238,1.0784566666666666,0.4714624455858997,1.4885283333333335,1.1850312227929498,Neutral,Neutral,Neutral,Neutral,Neutral,0.4882321261793763,1.0989512689327443,0.4166069789093635,1.61012,1.6885466666666666,0.6225908383652939,1.6493333333333333,1.116355419182647,Neutral,Neutral,Neutral,Neutral,1.9523619226351339,0.5769749795521362,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.3472,0.042,-22.2419,-4.22725305565164,0.2981978619328223,Benign,0.8096,pathogenic,-3.772,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M237W,NP_000537:p.Met237Trp,,,,,saturation_mutlist,,,,,,,,2.48227,1.273313958644867,,0.23154491385416143,,1.3569074569270807,,Uncertain,Uncertain,,Neutral,0.3637507947633401,,0.5768811852765692,2.93695,,0.15444508867480297,,1.5456975443374015,,Uncertain,,Neutral,,0.2264267603856038,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.4657,0.042,-22.2419,-7.06518272089547,0.8654221046411341,Pathogenic,0.9948,pathogenic,-4.764,available,https://doi.org/10.1101/2022.10.22.513328 +M237Y,NP_000537:p.Met237Tyr,,,,,saturation_mutlist,,,,,,,,1.96307,1.468433620929718,,0.6923805024189013,,1.3277252512094506,,Neutral,Uncertain,,Neutral,0.3653489157943665,,0.616940227673275,2.46821,,0.5489316647114563,,1.508570832355728,,Uncertain,,Neutral,,0.22642329995710636,19.023,4.878,16.095,9.711,,False,19.023,,neutral,neutral,neutral,,False,16.095,,neutral,neutral,neutral,damaging,,-0.4452,0.042,-22.2419,-6.67469361720534,0.6324763506857702,Uncertain,0.9854,pathogenic,-4.418,available,https://doi.org/10.1101/2022.10.22.513328 +C238A,NP_000537:p.Cys238Ala,,,,,saturation_mutlist,,,,,,,,0.29204,0.17868911266326903,,-0.10854237919562341,,0.0917488104021883,,Neutral,Neutral,,Neutral,0.27029013433051835,,0.13715987059753937,-0.22692,,0.3418126682655802,,0.0574463341327901,,Neutral,,Neutral,,0.5740571125468823,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.4925,0.0001,-22.239,-4.92685191703637,0.8708341942550044,Pathogenic,0.9995,pathogenic,-4.778,available,https://doi.org/10.1101/2022.10.22.513328 +C238D,NP_000537:p.Cys238Asp,,,,,saturation_mutlist,,,,,,,,-0.51005,0.3688401222229004,,0.07033315547910644,,-0.21985842226044677,,Neutral,Neutral,,Neutral,0.2768372842490813,,0.1795927191436334,1.32171,,1.351834017100151,,1.3367720085500756,,Neutral,,Neutral,,0.5694453551015981,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,uncertain,,-0.5998,0.0001,-22.239,-7.93506687281053,0.857659042722277,Pathogenic,0.9973,pathogenic,-4.806,available,https://doi.org/10.1101/2022.10.22.513328 +C238E,NP_000537:p.Cys238Glu,,,,,saturation_mutlist,,,,,,,,-0.12758,0.38747639417648316,,-0.2812465636379189,,-0.20441328181895946,,Neutral,Neutral,,Neutral,0.39289283287235427,,0.13166843369792264,0.01266,,1.118755659353585,,0.5657078296767925,,Neutral,,Neutral,,0.2806174969653581,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.5874,0.0001,-22.239,-7.93506687281053,0.854971183449035,Pathogenic,0.9999,pathogenic,-4.957,available,https://doi.org/10.1101/2022.10.22.513328 +C238F,NP_000537:p.Cys238Phe,"hg19,17:g.7577568C>A, hg19,17:g.7674250C>A, hg38,17:g.7674250C>A",,,0.958,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376574,Pathogenic/Likely pathogenic,2,,,,,4.9991,0.5025342798233032,4.05408,-0.9098336417332854,4.526590000000001,2.0446331791333576,Destabilizing,Uncertain,Neutral,Destabilizing,Uncertain,0.20422177278607714,0.4177117427924032,0.26678533263757304,10.13656,4.842289999999999,-0.6033162951228429,7.489424999999999,4.766621852438578,Destabilizing,Uncertain,Destabilizing,Destabilizing,1.9265897373511223,0.43274838073102945,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.4865,0.0001,-22.239,-8.21030175526727,0.8616765651067589,Pathogenic,0.9996,pathogenic,-4.634,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C238G,NP_000537:p.Cys238Gly,"hg19,17:g.7577569A>C, hg19,17:g.7674251A>C, hg38,17:g.7674251A>C",,,0.938,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376577,Pathogenic/Likely pathogenic,2,,,,,0.74702,0.7332114648818969,1.61474,1.3993373252593482,1.1808800000000002,1.0731786626296742,Neutral,Neutral,Neutral,Neutral,Neutral,0.377866835021964,0.8497904426778795,0.3018240437759125,-0.84248,1.5074866666666666,2.1242973084318275,0.3325033333333333,0.6409086542159137,Neutral,Uncertain,Neutral,Neutral,0.1301295872923944,0.38712711545691997,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.4849,0.0001,-22.239,-8.21030175526727,0.8704584281875574,Pathogenic,0.9956,pathogenic,-4.734,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C238H,NP_000537:p.Cys238His,,,,,saturation_mutlist,,,,,,,,4.02872,0.2147563862800598,,-0.48589284792407667,,1.7714135760379617,,Uncertain,Neutral,,Neutral,0.2561601300829307,,0.25901826895391705,7.96304,,0.270858098011841,,4.116949049005921,,Uncertain,,Destabilizing,,0.22334803565151026,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.5982,0.0001,-22.239,-8.21030175526727,0.8630942632464149,Pathogenic,0.9997,pathogenic,-4.763,available,https://doi.org/10.1101/2022.10.22.513328 +C238I,NP_000537:p.Cys238Ile,,,,,saturation_mutlist,,,,,,,,0.30048,0.7619897437095642,,-1.0002437833146407,,-0.3498818916573203,,Neutral,Neutral,,Neutral,0.2890191050162131,,0.10255502034503687,2.43148,,-0.6944146093966661,,0.868532695301667,,Uncertain,,Neutral,,0.34656528823096217,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.5163,0.0001,-22.239,-7.77406478768294,0.8682761041443985,Pathogenic,0.9999,pathogenic,-4.896,available,https://doi.org/10.1101/2022.10.22.513328 +C238K,NP_000537:p.Cys238Lys,,,,,saturation_mutlist,,,,,,,,1.96894,1.032285852432251,,0.30973933627436706,,1.1393396681371835,,Neutral,Uncertain,,Neutral,0.3086128182027377,,0.171558119251242,6.40171,,2.4862241837500907,,4.443967091875045,,Uncertain,,Destabilizing,,0.5425632909483111,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.588,0.0001,-22.239,-8.21030175526727,0.8684032593180526,Pathogenic,1.0,pathogenic,-4.912,available,https://doi.org/10.1101/2022.10.22.513328 +C238L,NP_000537:p.Cys238Leu,,,,,saturation_mutlist,,,,,,,,0.09638,0.7889614486694336,,-1.2689381062377263,,-0.5862790531188632,,Neutral,Neutral,,Neutral,0.27247150307178164,,0.05036575441962786,1.85176,,-1.1821279642100795,,0.3348160178949603,,Neutral,,Neutral,,0.03840577723295785,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.5494,0.0001,-22.239,-7.77406478768294,0.8637393089590331,Pathogenic,0.9994,pathogenic,-4.751,available,https://doi.org/10.1101/2022.10.22.513328 +C238M,NP_000537:p.Cys238Met,,,,,saturation_mutlist,,,,,,,,-0.43123,0.45050998210906984,,-0.9031059594080159,,-0.667167979704008,,Neutral,Neutral,,Neutral,0.2647415999065455,,0.10950496574275073,1.77047,,-0.5546390861795732,,0.6079154569102134,,Neutral,,Neutral,,0.12620802023163288,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.5166,0.0001,-22.239,-7.77406478768294,0.8683052478293456,Pathogenic,0.9998,pathogenic,-4.87,available,https://doi.org/10.1101/2022.10.22.513328 +C238N,NP_000537:p.Cys238Asn,,,,,saturation_mutlist,,,,,,,,-0.14981,0.500287766456604,,-0.11037420784049749,,-0.13009210392024875,,Neutral,Neutral,,Neutral,0.2941794850851453,,0.21123198055276818,1.69505,,0.2614069267674572,,0.9782284633837286,,Neutral,,Neutral,,0.5993841825659495,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.5422,0.0001,-22.239,-7.93506687281053,0.8654010543595481,Pathogenic,0.9998,pathogenic,-4.781,available,https://doi.org/10.1101/2022.10.22.513328 +C238P,NP_000537:p.Cys238Pro,,,,,saturation_mutlist,,,,,,,,1.84951,1.6011144638061523,,5.369123249297363,,3.609316624648682,,Uncertain,Uncertain,,Destabilizing,0.3502436344489734,,0.6850599784051226,5.44903,,5.5923900600775385,,5.520710030038769,,Destabilizing,,Destabilizing,,1.17358509984125,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,uncertain,,-0.6108,0.0001,-22.239,-8.21030175526727,0.8685423719985923,Pathogenic,0.9999,pathogenic,-4.914,available,https://doi.org/10.1101/2022.10.22.513328 +C238Q,NP_000537:p.Cys238Gln,,,,,saturation_mutlist,,,,,,,,0.75486,0.39397292613983154,,-0.27586561976105206,,0.23949719011947396,,Neutral,Neutral,,Neutral,0.27175589317799864,,0.16310012311244892,3.47627,,0.46317232372071276,,1.9697211618603563,,Uncertain,,Neutral,,0.17554954041673196,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.5661,0.0001,-22.239,-7.93506687281053,0.8090215897349788,Pathogenic,1.0,pathogenic,-4.768,available,https://doi.org/10.1101/2022.10.22.513328 +C238R,NP_000537:p.Cys238Arg,"hg19,17:g.7577569A>G, hg19,17:g.7674251A>G, hg38,17:g.7674251A>G",,,0.954,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376576,Pathogenic/Likely pathogenic,2,,,,,2.16276,0.9992981016635895,4.828006666666667,-0.1779271649647619,3.4953833333333337,0.9924164175176191,Uncertain,Uncertain,Neutral,Destabilizing,Neutral,0.3153766346060912,1.2131205652182948,0.14175389602652191,10.0854,8.09263,1.122274904544715,9.089015,5.603837452272358,Destabilizing,Uncertain,Destabilizing,Destabilizing,2.722983264472994,0.5698258987823529,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.5448,0.0001,-22.239,-8.21030175526727,0.8708431597106373,Pathogenic,0.9997,pathogenic,-4.7,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C238S,NP_000537:p.Cys238Ser,"hg19,17:g.7577568C>G, hg19,17:g.7577569A>T, hg19,17:g.7674250C>G, hg19,17:g.7674251A>T, hg38,17:g.7674250C>G, hg38,17:g.7674251A>T",,,"0.946, 0.956","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","485039, 376575","Conflicting classifications of pathogenicity, Pathogenic/Likely pathogenic","1, 2",,,,,-0.08296,0.202483651638031,0.6950133333333334,0.5614336118461732,0.30602666666666667,0.2392368059230866,Neutral,Neutral,Neutral,Neutral,Neutral,0.29428672605213796,0.7418714606692696,0.1655051711313549,0.60052,0.5299333333333333,1.3402521731821289,0.5652266666666667,0.9703860865910645,Neutral,Neutral,Neutral,Neutral,0.31796601058743507,0.5625047240144613,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.4833,0.0001,-22.239,-4.92685191703637,0.8609480651884298,Pathogenic,0.9996,pathogenic,-4.587,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C238T,NP_000537:p.Cys238Thr,,,,,saturation_mutlist,,,,,,,,0.75603,0.6350995349884033,,-0.10209432959946885,,0.32696783520026557,,Neutral,Neutral,,Neutral,0.21734565776327497,,0.17897687683581784,1.57133,,0.5265058779434334,,1.0489179389717167,,Neutral,,Neutral,,0.5897351635888052,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.5179,0.0001,-22.239,-4.92685191703637,0.86517533073567,Pathogenic,0.9998,pathogenic,-4.758,available,https://doi.org/10.1101/2022.10.22.513328 +C238V,NP_000537:p.Cys238Val,,,,,saturation_mutlist,,,,,,,,0.29342,0.6672737908363342,,-0.8866027045543242,,-0.2965913522771621,,Neutral,Neutral,,Neutral,0.29967914464333995,,0.24098903754156517,1.14706,,-0.7682787017056719,,0.18939064914716403,,Neutral,,Neutral,,0.49902616070130484,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.5144,0.0001,-22.239,-6.39664703324571,0.8499550722638951,Pathogenic,0.9994,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +C238W,NP_000537:p.Cys238Trp,"hg19,17:g.7577567A>C, hg19,17:g.7674249A>C, hg38,17:g.7674249A>C",,,0.896,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",161515,Pathogenic/Likely pathogenic,2,,,,,5.38994,0.17705439090728758,7.457710000000001,-1.1343539880221891,6.423825000000001,2.1277930059889054,Destabilizing,Uncertain,Neutral,Destabilizing,Uncertain,0.24650769071856263,3.9934014506933817,0.1909171750127073,19.10652,8.423016666666667,0.39755416795518816,13.764768333333333,9.752037083977594,Destabilizing,Uncertain,Destabilizing,Destabilizing,3.5429236458828113,0.8547055385252564,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.4896,0.0001,-22.239,-8.21030175526727,0.8697837217553264,Pathogenic,0.9996,pathogenic,-4.767,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C238Y,NP_000537:p.Cys238Tyr,"hg19,17:g.7577568C>T, hg19,17:g.7674250C>T, hg38,17:g.7674250C>T",,7.9531084724e-06,0.957,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182935,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,5.50411,0.2634135150909424,5.125736666666667,-0.6308886845616871,5.314923333333333,2.4366106577191564,Destabilizing,Uncertain,Neutral,Destabilizing,Uncertain,0.31572519838730817,1.968021911672282,0.33558898498704043,12.82234,9.38991,0.24535001502581497,11.106125,6.533845007512908,Destabilizing,Uncertain,Destabilizing,Destabilizing,5.660200058413719,0.5437898158836881,4.682,2.801,1.23,1.752,,False,4.682,,neutral,neutral,neutral,,False,1.23,,neutral,neutral,neutral,neutral,,-0.4958,0.0001,-22.239,-8.21030175526727,0.8690336188448511,Pathogenic,0.9996,pathogenic,-4.662,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239A,NP_000537:p.Asn239Ala,,,,,saturation_mutlist,,,,,,,,-0.07289,0.31594736576080323,,0.6976934048013682,,0.3124017024006841,,Neutral,Neutral,,Neutral,0.5284609019615869,,0.3413872944785759,-0.33063,,0.9125649803162269,,0.29096749015811346,,Neutral,,Neutral,,0.5063607571718832,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,neutral,,-0.325,0.0421,-22.239,-6.73670461250089,0.7792649874674429,Pathogenic,0.9892,pathogenic,-4.219,available,https://doi.org/10.1101/2022.10.22.513328 +N239C,NP_000537:p.Asn239Cys,,,,,saturation_mutlist,,,,,,,,-0.05912,-0.20847691535949708,,1.0774883498934864,,0.5091841749467432,,Neutral,Neutral,,Neutral,0.30701201703543535,,0.2928805132947945,-0.084,,1.4369681587742196,,0.6764840793871097,,Neutral,,Neutral,,0.3328659022723098,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,neutral,,-0.3749,0.0421,-22.239,-6.24538504464986,0.6933930531843053,Pathogenic,0.9452,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328 +N239D,NP_000537:p.Asn239Asp,"hg19,17:g.7577566T>C, hg19,17:g.7674248T>C, hg38,17:g.7674248T>C",,,0.948,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",234036,Conflicting classifications of pathogenicity,1,,,,,0.04199,0.4893175685405731,0.28401666666666664,0.6184595177206367,0.16300333333333333,0.3302247588603183,Neutral,Neutral,Neutral,Neutral,Neutral,0.19250633183353322,0.2737037524201831,0.20812737186159605,-0.19767,-0.07267666666666667,0.6247932061876402,-0.13517333333333334,0.2135616030938201,Neutral,Neutral,Neutral,Neutral,0.09500589817947562,0.3943635798074439,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.3282,0.0421,-22.239,-4.51839023397795,0.8245311876138701,Pathogenic,0.9944,pathogenic,-4.34,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239E,NP_000537:p.Asn239Glu,,,,,saturation_mutlist,,,,,,,,-0.25501,0.5634574419260026,,0.563209833076208,,0.15409991653810398,,Neutral,Neutral,,Neutral,0.5796113197912622,,0.36435029434635946,-0.72746,,0.5619600039623586,,-0.08274999801882071,,Neutral,,Neutral,,0.46978569477672655,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.3554,0.0421,-22.239,-4.51839023397795,0.8442157194287963,Pathogenic,0.9992,pathogenic,-4.502,available,https://doi.org/10.1101/2022.10.22.513328 +N239F,NP_000537:p.Asn239Phe,,,,,saturation_mutlist,,,,,,,,1.55044,0.09464988708496094,,-0.08142214190100787,,0.734508929049496,,Neutral,Neutral,,Neutral,0.41402953984662444,,0.24611541829012207,-0.69456,,-0.12183911421201322,,-0.4081995571060066,,Neutral,,Neutral,,0.5887117867682677,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.3822,0.0421,-22.239,-4.41356815645093,0.3020670905389341,Benign,0.938,pathogenic,-3.997,available,https://doi.org/10.1101/2022.10.22.513328 +N239G,NP_000537:p.Asn239Gly,,,,,saturation_mutlist,,,,,,,,0.8693,0.5918782061338425,,1.5708209503161015,,1.2200604751580508,,Neutral,Neutral,,Neutral,0.4898196264508571,,0.40083575227435575,-0.20795,,1.7879123839365814,,0.7899811919682906,,Neutral,,Neutral,,0.37013688382988624,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,neutral,,-0.3558,0.0421,-22.239,-7.49395404431902,0.6452406412705574,Uncertain,0.9841,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328 +N239H,NP_000537:p.Asn239His,"hg19,17:g.7577566T>G, hg38,17:g.7674248T>G",,,0.927,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.19754,-0.19695119857788085,-0.44138666666666665,0.12349311542460072,0.3780766666666667,0.6605165577123003,Neutral,Neutral,Neutral,Neutral,Neutral,0.3324423828194503,0.2000243785697689,0.19621191088677353,-0.01374,0.6608833333333334,0.20108208897507637,0.3235716666666667,0.09367104448753819,Neutral,Neutral,Neutral,Neutral,0.5689035469704469,0.5761703007435458,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.2622,0.0421,-8.9511,-5.44224221544363,0.1094726625041875,Benign,0.8636,pathogenic,-3.902,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239I,NP_000537:p.Asn239Ile,"hg19,17:g.7577565T>A, hg38,17:g.7674247T>A",,,0.943,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2748594,Conflicting classifications of pathogenicity,1,,,,,-0.12588,0.5226289939880371,0.4562366666666667,0.06849748204037627,0.16517833333333334,-0.02869125897981186,Neutral,Neutral,Neutral,Neutral,Neutral,0.549175413231749,0.7433651507091847,0.2869061739054919,-0.31041,0.01156333333333335,-0.02454041731766841,-0.14942333333333332,-0.16747520865883422,Neutral,Neutral,Neutral,Neutral,0.5748864830748955,0.471488445980322,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.3753,0.0421,-22.239,-5.7415489894666,0.8610894658864068,Pathogenic,0.9897,pathogenic,-4.473,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239K,NP_000537:p.Asn239Lys,"hg19,17:g.7577564G>C, hg19,17:g.7577564G>T, hg38,17:g.7674246G>C, hg38,17:g.7674246G>T",,,0.811,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","4189258, 385614","Pathogenic, Conflicting classifications of pathogenicity","1, 1",,,,,-0.66987,0.43511481761932375,1.3492066666666667,0.7172867424419153,0.33966833333333335,0.023708371220957647,Neutral,Neutral,Neutral,Neutral,Neutral,0.5845405575777239,0.9215601591624693,0.36100865600242427,-0.80763,0.6733533333333334,0.6939737046672394,-0.0671383333333333,-0.05682814766638028,Neutral,Neutral,Neutral,Neutral,0.5105631769156704,0.50552198365459,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.3282,0.0421,-22.239,-5.33968560339234,0.1284204288338064,Benign,0.9959,pathogenic,-3.783,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239L,NP_000537:p.Asn239Leu,,,,,saturation_mutlist,,,,,,,,-1.08569,0.41091511249542234,,-0.2022702393877046,,-0.6439801196938524,,Neutral,Neutral,,Neutral,0.4472449238123469,,0.2630363073596337,-1.20344,,-0.3330792097133202,,-0.7682596048566601,,Neutral,,Neutral,,0.4245776548971919,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.3817,0.0421,-22.239,-4.57202662186752,0.0740550907923182,Benign,0.8828,pathogenic,-3.818,available,https://doi.org/10.1101/2022.10.22.513328 +N239M,NP_000537:p.Asn239Met,,,,,saturation_mutlist,,,,,,,,-1.17851,0.38042624831199645,,0.22002590133807157,,-0.4792420493309642,,Neutral,Neutral,,Neutral,0.4584029844812147,,0.2778750684944241,-1.18813,,0.11172407239216907,,-0.5382029638039154,,Neutral,,Neutral,,0.41234677347454923,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.3359,0.0421,-22.239,-5.57183693448015,0.5869889111837324,Uncertain,0.9795,pathogenic,-4.224,available,https://doi.org/10.1101/2022.10.22.513328 +N239P,NP_000537:p.Asn239Pro,,,,,saturation_mutlist,,,,,,,,-0.31929,1.0689722561836243,,2.68077497253482,,1.18074248626741,,Uncertain,Uncertain,,Neutral,0.8270356994488033,,0.4993877133990304,2.2702,,3.2393303125335287,,2.7547651562667643,,Uncertain,,Uncertain,,0.7384754314797989,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.4906,0.0421,-22.239,-5.82620420376815,0.8664021515623944,Pathogenic,0.9854,pathogenic,-4.45,available,https://doi.org/10.1101/2022.10.22.513328 +N239Q,NP_000537:p.Asn239Gln,,,,,saturation_mutlist,,,,,,,,-0.1811,0.36641198515892026,,0.6858612577029968,,0.25238062885149837,,Neutral,Neutral,,Neutral,0.5535900727388464,,0.27766653418282805,-0.43403,,0.7520443551699231,,0.15900717758496152,,Neutral,,Neutral,,0.39318682588175863,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.319,0.0421,-22.239,-4.51839023397795,0.728443676422765,Pathogenic,0.9932,pathogenic,-3.942,available,https://doi.org/10.1101/2022.10.22.513328 +N239R,NP_000537:p.Asn239Arg,,,,,saturation_mutlist,,,,,,,,-0.29578,0.460404087305069,,0.369957839722195,,0.0370889198610975,,Neutral,Neutral,,Neutral,0.5758752160658039,,0.3147219012731826,-0.51757,,0.36239677466807474,,-0.07758661266596262,,Neutral,,Neutral,,0.5402413395025761,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.3604,0.0421,-22.239,-5.04641763183701,0.3280496675686711,Uncertain,0.9885,pathogenic,-3.956,available,https://doi.org/10.1101/2022.10.22.513328 +N239S,NP_000537:p.Asn239Ser,"hg19,17:g.7577565T>C, hg19,17:g.7674247T>C, hg38,17:g.7674246_7674247inv, hg38,17:g.7674247T>C",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376637,Pathogenic/Likely pathogenic,2,,,,,0.48985,0.1934496808052063,0.8055533333333332,0.9409531809654137,0.6477016666666666,0.7154015904827069,Neutral,Neutral,Neutral,Neutral,Neutral,0.38909693204687795,0.7434606154255172,0.3531651481765688,0.21388,0.5646266666666667,1.0996833385389044,0.38925333333333334,0.6567816692694523,Neutral,Neutral,Neutral,Neutral,0.8660238091543572,0.4674684812575671,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,neutral,,-0.2271,0.0421,-8.9511,-4.23527283879432,0.3725484560732603,Uncertain,0.7939,pathogenic,-3.748,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239T,NP_000537:p.Asn239Thr,"hg19,17:g.7577565T>G, hg38,17:g.7674247T>G",,,0.935,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376638,Conflicting classifications of pathogenicity,1,,,,,0.39855,0.5375662398338318,0.17029333333333327,0.6640316992388161,0.28442166666666663,0.5312908496194081,Neutral,Neutral,Neutral,Neutral,Neutral,0.6129421012850779,1.8399442388893807,0.30086448349523953,0.13822,0.8653066666666667,0.7877274912117297,0.5017633333333333,0.46297374560586485,Neutral,Neutral,Neutral,Neutral,0.40722675471480946,0.47659174684281663,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.3445,0.0421,-22.239,-5.72677100872193,0.777712395277191,Pathogenic,0.9759,pathogenic,-4.007,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239V,NP_000537:p.Asn239Val,,,,,saturation_mutlist,,,,,,,,-0.02593,0.5602503514289856,,0.21516740831419837,,0.09461870415709918,,Neutral,Neutral,,Neutral,0.5391413917936803,,0.1859313631855018,-0.22523,,0.20926924746004028,,-0.00798037626997987,,Neutral,,Neutral,,0.5051919521134058,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.3687,0.0421,-22.239,-5.7415489894666,0.7696121450409021,Pathogenic,0.9874,pathogenic,-4.324,available,https://doi.org/10.1101/2022.10.22.513328 +N239W,NP_000537:p.Asn239Trp,,,,,saturation_mutlist,,,,,,,,2.13661,0.15426888704299926,,-0.33499688154173496,,0.9008065592291326,,Uncertain,Neutral,,Neutral,0.4021881278795229,,0.22358236271106846,-0.20122,,-0.47785097986685593,,-0.33953548993342797,,Neutral,,Neutral,,0.641734835310547,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.3873,0.0421,-22.239,-5.69964534233217,0.8592846433446831,Pathogenic,0.9928,pathogenic,-4.701,available,https://doi.org/10.1101/2022.10.22.513328 +N239Y,NP_000537:p.Asn239Tyr,"hg19,17:g.7577566T>A, hg38,17:g.7674248T>A",,,0.905,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.29277,-0.10789268732070922,1.1767566666666667,0.05299100577536442,1.7347633333333334,1.1728805028876823,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.45469301051054617,0.7064703395205083,0.24031162255466887,-0.30336,1.448413333333333,0.034283378546342454,0.5725266666666665,-0.13453831072682879,Neutral,Neutral,Neutral,Neutral,0.76865350504777,0.5919265412186632,20.941,4.91,43.21,8.981,,False,20.941,,neutral,neutral,neutral,,False,43.21,,neutral,neutral,neutral,uncertain,,-0.3657,0.0421,-22.239,-2.55273457862813,0.1664178693747725,Benign,0.8137,pathogenic,-4.024,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240A,NP_000537:p.Ser240Ala,,,,,saturation_mutlist,,,,,,,,-0.31597,0.4185257315635681,,-0.8698639817795373,,-0.5929169908897687,,Neutral,Neutral,,Neutral,0.4093115258969401,,0.08915770095541058,-0.67478,,-0.8152480380036934,,-0.7450140190018467,,Neutral,,Neutral,,0.1315280940859573,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,uncertain,,-0.2805,0.0001,-22.239,-4.74966987468903,0.8691517937731715,Pathogenic,0.9236,pathogenic,-4.204,available,https://doi.org/10.1101/2022.10.22.513328 +S240C,NP_000537:p.Ser240Cys,"hg19,17:g.7577563T>A, hg38,17:g.7674245T>A",,,0.923,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3972460,Likely pathogenic,1,,,,,-0.46106,0.38780607223510744,0.28163333333333335,-0.3420652098270023,-0.08971333333333334,-0.40156260491350115,Neutral,Neutral,Neutral,Neutral,Neutral,0.37620178601973747,0.5809759901139537,0.14427657718827752,-0.44602,-0.23004666666666665,-0.17744547020730103,-0.33803333333333335,-0.3117327351036505,Neutral,Neutral,Neutral,Neutral,0.22098387729022728,0.23000841723236648,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.331,0.0001,-22.239,-4.74966987468903,0.8603000931140408,Pathogenic,0.965,pathogenic,-4.328,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240D,NP_000537:p.Ser240Asp,,,,,saturation_mutlist,,,,,,,,0.90603,0.5858705759048461,,0.3495665362921448,,0.6277982681460724,,Neutral,Neutral,,Neutral,0.5196252279552894,,0.32168314980563595,0.29453,,-0.01639144328771253,,0.13906927835614374,,Neutral,,Neutral,,0.38244982695012053,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3792,0.0001,-22.239,-6.11525662181294,0.8708626127153459,Pathogenic,0.9988,pathogenic,-4.557,available,https://doi.org/10.1101/2022.10.22.513328 +S240E,NP_000537:p.Ser240Glu,,,,,saturation_mutlist,,,,,,,,1.63154,0.9288230609893798,,0.314978226188394,,0.973259113094197,,Neutral,Neutral,,Neutral,0.8247690453420535,,0.24861431315268798,0.70844,,-0.261307255743422,,0.22356637212828898,,Neutral,,Neutral,,0.36471247833090953,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3523,0.0001,-22.239,-6.11525662181294,0.8683016159752266,Pathogenic,0.9993,pathogenic,-4.708,available,https://doi.org/10.1101/2022.10.22.513328 +S240F,NP_000537:p.Ser240Phe,"hg19,17:g.7577562_7577563delinsAA, hg38,17:g.7674244_7674245delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,5.30492,1.1808289611339569,-1.5229,-0.6119975901572713,1.89101,2.3464612049213645,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,0.6051718885605768,1.604573956351031,0.0422075207041216,1.71806,0.8058966666666668,-1.520624330389322,1.2619783333333334,0.09871783480533891,Neutral,Neutral,Neutral,Neutral,2.560338905618204,0.12874054863609963,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3585,0.0001,-22.239,-7.47258067390211,0.8512378421854259,Pathogenic,0.998,pathogenic,-4.6,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240G,NP_000537:p.Ser240Gly,"hg19,17:g.7577563T>C, hg19,17:g.7674245T>C, hg38,17:g.7674245T>C",,,0.872,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",584921,Pathogenic/Likely pathogenic,2,,,,,0.9527,0.8098938703536988,1.1196166666666667,0.572196632246582,1.0361583333333333,0.762448316123291,Neutral,Neutral,Neutral,Neutral,Neutral,0.4274756480974092,0.52691793018985,0.05099630208356658,-1.59779,1.1181400000000001,0.6936078390203796,-0.23982499999999995,-0.4520910804898102,Neutral,Neutral,Neutral,Neutral,0.37241621581236234,0.08937939041803196,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,uncertain,,-0.2896,0.0001,-22.239,-4.8180146382902,0.4562981497441074,Uncertain,0.8955,pathogenic,-3.766,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240H,NP_000537:p.Ser240His,,,,,saturation_mutlist,,,,,,,,6.32095,0.9214664506912231,,-0.31831902018824243,,3.0013154899058785,,Uncertain,Neutral,,Destabilizing,0.8817618893125718,,0.15951588752837603,2.4719,,-1.0738372860312555,,0.6990313569843724,,Uncertain,,Neutral,,0.33522556198009684,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3598,0.0001,-22.239,-7.27200386010493,0.852665887818963,Pathogenic,0.9959,pathogenic,-4.361,available,https://doi.org/10.1101/2022.10.22.513328 +S240I,NP_000537:p.Ser240Ile,"hg19,17:g.7577562C>A, hg38,17:g.7674244C>A",,,0.883,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1036853,Uncertain significance,2,,,,,1.28797,1.1451097488403321,0.7587266666666667,-0.8154755525974194,1.0233483333333333,0.2362472237012903,Neutral,Neutral,Uncertain,Neutral,Neutral,0.6599393518120767,1.3351826220242515,0.06745233817882956,0.74975,-1.0575966666666667,-0.9204227200127955,-0.15392333333333336,-0.08533636000639772,Neutral,Neutral,Neutral,Neutral,0.47237103752123594,0.25977711564904743,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3617,0.0001,-22.239,-4.94063288282226,0.6959523093181621,Pathogenic,0.9894,pathogenic,-4.272,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240K,NP_000537:p.Ser240Lys,,,,,saturation_mutlist,,,,,,,,3.18218,1.4300402998924255,,1.3990351774493053,,2.2906075887246526,,Uncertain,Uncertain,,Uncertain,0.7915050868506962,,0.5291686152483485,0.96098,,0.42094301066884904,,0.6909615053344245,,Neutral,,Neutral,,0.4321859849485806,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3691,0.0001,-22.239,-7.62779271728591,0.867154259992369,Pathogenic,0.9998,pathogenic,-4.49,available,https://doi.org/10.1101/2022.10.22.513328 +S240L,NP_000537:p.Ser240Leu,,,,,saturation_mutlist,,,,,,,,1.56964,1.3153867936134338,,-1.2602607816627796,,0.1546896091686102,,Neutral,Uncertain,,Neutral,0.6741182993089222,,0.13275627263913875,-1.07292,,-1.4458576154491347,,-1.2593888077245674,,Neutral,,Neutral,,0.15381390500206554,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3579,0.0001,-22.239,-5.83198615151235,0.5988636034571956,Uncertain,0.9887,pathogenic,-4.366,available,https://doi.org/10.1101/2022.10.22.513328 +S240M,NP_000537:p.Ser240Met,,,,,saturation_mutlist,,,,,,,,0.59773,0.9727408456802368,,-1.0438424583300914,,-0.2230562291650457,,Neutral,Neutral,,Neutral,0.5806279106036433,,0.19573360023526146,-1.06486,,-1.1832445591464096,,-1.1240522795732049,,Neutral,,Neutral,,0.20252223463383145,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.329,0.0001,-22.239,-6.80857538989954,0.8696082787686332,Pathogenic,0.9925,pathogenic,-4.594,available,https://doi.org/10.1101/2022.10.22.513328 +S240N,NP_000537:p.Ser240Asn,"hg19,17:g.7577562C>T, hg38,17:g.7674244C>T",,,0.750,"cBioPortal,ClinVar,saturation_mutlist",2502882,Pathogenic,0,,,,,1.16497,0.7338815069198609,0.7709733333333334,-0.5651788166168901,0.9679716666666667,0.299895591691555,Neutral,Neutral,Neutral,Neutral,Neutral,0.5636063814626232,1.0571660291027558,0.14797663775443487,0.03403,-0.06156333333333334,-0.4465797803224752,-0.01376666666666667,-0.2062748901612376,Neutral,Neutral,Neutral,Neutral,0.4545448400567563,0.37759164108305204,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3028,0.0001,-22.239,-5.00618289110594,0.2023934074144075,Benign,0.9618,pathogenic,-3.708,available,https://doi.org/10.1101/2022.10.22.513328 +S240P,NP_000537:p.Ser240Pro,"hg38,17:g.7674243_7674245delinsGGG",,,,"COSMIC,saturation_mutlist",,,,,,,,4.83306,1.3076051926612855,3.269956666666667,4.864536338349761,4.0515083333333335,4.848798169174881,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.5945003375129108,1.5041631445277321,0.2500152838984964,6.22916,3.8718833333333333,3.8212408880205437,5.050521666666667,5.025200444010272,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.9616587051316885,0.8246154762518827,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.4339,0.0001,-22.239,-7.89312945800426,0.8687180525642478,Pathogenic,0.9978,pathogenic,-4.527,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240Q,NP_000537:p.Ser240Gln,,,,,saturation_mutlist,,,,,,,,2.18553,0.9357347750663757,,-0.2854340884085469,,0.9500479557957265,,Uncertain,Neutral,,Neutral,0.8314520851643011,,0.1233260255262446,0.55919,,-0.492897533162069,,0.03314623341896547,,Neutral,,Neutral,,0.2794572544746714,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3224,0.0001,-22.239,-6.11525662181294,0.8647708597094842,Pathogenic,0.9982,pathogenic,-4.481,available,https://doi.org/10.1101/2022.10.22.513328 +S240R,NP_000537:p.Ser240Arg,"hg19,17:g.7577561A>C, hg19,17:g.7577561A>T, hg19,17:g.7577563T>G, hg19,17:g.7674243A>C, hg19,17:g.7674243A>T, hg38,17:g.7674243A>C, hg38,17:g.7674243A>T, hg38,17:g.7674245T>G",,,"0.908, 0.939","cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","1504304, 826894, 458559","Uncertain significance, Conflicting classifications of pathogenicity, Uncertain significance","2, 1, 2",,,,,4.06953,1.3362542855739594,0.08865999999999996,0.20988406694385717,2.079095,2.139707033471929,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.7262652881974374,0.8136647784356077,0.2977540913769841,1.23024,0.17845999999999998,-0.39807077557438647,0.70435,0.4160846122128068,Neutral,Neutral,Neutral,Neutral,0.09139439187754721,0.38133421469590706,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3743,0.0001,-22.239,-4.54427391360842,0.8630812922548369,Pathogenic,0.9995,pathogenic,-4.454,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240T,NP_000537:p.Ser240Thr,"hg38,17:g.7674244C>G",,,0.800,"COSMIC,saturation_mutlist",,,,,,,,0.7399,0.18601244688034058,-0.44342333333333334,-0.4497962127806637,0.14823833333333333,0.14505189360966816,Neutral,Neutral,Neutral,Neutral,Neutral,0.2841903762006691,0.9569947047688171,0.07719403508026199,0.90811,-0.5284599999999999,-0.29096143520235057,0.18982500000000002,0.3085742823988247,Neutral,Neutral,Neutral,Neutral,0.06235311753767142,0.20861313469554546,5.113,6.047,12.145,6.753,,False,5.113,,neutral,,,,False,12.145,,neutral,,,neutral,,-0.2712,0.0001,-22.239,-3.64003872030778,0.022294891273976,Benign,0.8618,pathogenic,-3.712,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240V,NP_000537:p.Ser240Val,,,,,saturation_mutlist,,,,,,,,0.65975,0.9152005648612976,,-1.0459690847294631,,-0.1931095423647316,,Neutral,Neutral,,Neutral,0.519492523585355,,0.1801393590583624,0.68422,,-0.8473107915815152,,-0.08154539579075759,,Neutral,,Neutral,,0.3333211256514429,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3359,0.0001,-22.239,-6.80857538989954,0.8676758737811677,Pathogenic,0.9935,pathogenic,-4.584,available,https://doi.org/10.1101/2022.10.22.513328 +S240W,NP_000537:p.Ser240Trp,,,,,saturation_mutlist,,,,,,,,7.75859,1.204222731590271,,-0.07862170141095234,,3.8399841492945237,,Uncertain,Uncertain,,Destabilizing,0.7370593403227202,,0.3768003002448374,2.79881,,-1.6554449560574722,,0.5716825219712639,,Uncertain,,Neutral,,0.15878888922159626,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3682,0.0001,-22.239,-7.47258067390211,0.8649742272374237,Pathogenic,0.9972,pathogenic,-4.745,available,https://doi.org/10.1101/2022.10.22.513328 +S240Y,NP_000537:p.Ser240Tyr,,,,,saturation_mutlist,,,,,,,,6.40731,1.2333123147487641,,-0.023887880131323758,,3.191711059934338,,Uncertain,Uncertain,,Destabilizing,0.8775489265455906,,0.24668101870757086,1.6634,,-1.2518693555162195,,0.20576532224189026,,Neutral,,Neutral,,0.18043816544274732,5.113,6.047,12.145,6.753,,False,5.113,,uncertain,,,,False,12.145,,uncertain,,,neutral,,-0.3633,0.0001,-22.239,-7.47258067390211,0.8700907370140724,Pathogenic,0.9952,pathogenic,-4.639,available,https://doi.org/10.1101/2022.10.22.513328 +S241A,NP_000537:p.Ser241Ala,"hg19,17:g.7577560A>C, hg19,17:g.7674242A>C, hg38,17:g.7674242A>C",,,0.858,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376665,Pathogenic/Likely pathogenic,2,,,,,0.21535,0.11585335969924924,0.16995666666666667,0.016112100055394166,0.19265333333333334,0.1157310500276971,Neutral,Neutral,Neutral,Neutral,Neutral,0.10274909036154771,0.22559476372961812,0.14237000133344918,0.2021,0.09909333333333332,0.04980421741079921,0.15059666666666666,0.1259521087053996,Neutral,Neutral,Neutral,Neutral,0.20246795472096046,0.21244330241661846,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,uncertain,,-0.2805,0.0001,-22.239,-4.92685191703637,0.8223519077022089,Pathogenic,0.9765,pathogenic,-4.111,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S241C,NP_000537:p.Ser241Cys,"hg19,17:g.7577559G>C, hg19,17:g.7674241G>C, hg38,17:g.7674241G>C",,0.0,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",177791,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,0.33098,-0.2570528149604797,0.9341266666666668,0.6473145864430846,0.6325533333333334,0.48914729322154227,Neutral,Neutral,Neutral,Neutral,Neutral,0.10792239323276955,0.08098076822445084,0.05680682204176299,0.42893,0.5057833333333334,0.7226105766069595,0.46735666666666664,0.5757702883034798,Neutral,Neutral,Neutral,Neutral,0.4000758561684133,0.11319976900842484,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.331,0.0001,-22.239,-4.92685191703637,0.8692039119456415,Pathogenic,0.998,pathogenic,-4.397,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S241D,NP_000537:p.Ser241Asp,,,,,saturation_mutlist,,,,,,,,0.0978,-0.07875833988189697,,-0.19238415477267137,,-0.04729207738633569,,Neutral,Neutral,,Neutral,0.10380022965716425,,0.0861312596901025,0.05606,,-0.2501390513486142,,-0.0970395256743071,,Neutral,,Neutral,,0.11057622596932734,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3792,0.0001,-22.239,-8.21030175526727,0.8497631074243504,Pathogenic,0.9997,pathogenic,-4.424,available,https://doi.org/10.1101/2022.10.22.513328 +S241E,NP_000537:p.Ser241Glu,,,,,saturation_mutlist,,,,,,,,0.12099,0.07866501331329345,,-0.14725497039210791,,-0.013132485196053957,,Neutral,Neutral,,Neutral,0.2005798553260571,,0.05466200844305341,0.05492,,-0.30785798457064617,,-0.1264689922853231,,Neutral,,Neutral,,0.1126452633123216,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3523,0.0001,-22.239,-8.21030175526727,0.8666231014963055,Pathogenic,0.9993,pathogenic,-4.744,available,https://doi.org/10.1101/2022.10.22.513328 +S241F,NP_000537:p.Ser241Phe,"hg19,17:g.7577558_7577559delinsAA, hg19,17:g.7577559G>A, hg19,17:g.7674240_7674241delinsAA, hg19,17:g.7674241G>A, hg38,17:g.7674240_7674241delinsAA, hg38,17:g.7674241G>A",,3.9765226105e-06,0.958,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12359,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,0.21078,0.04343125343322754,-0.006460000000000003,-0.5228697660126241,0.10216,-0.15604488300631209,Neutral,Neutral,Neutral,Neutral,Neutral,0.14049237213914728,0.38222654913894544,0.19954921867984227,0.08281,-0.63923,-0.4376884302636526,-0.27820999999999996,-0.1774392151318263,Neutral,Neutral,Neutral,Neutral,0.10721393472865362,0.10337439770330006,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3585,0.0001,-22.239,-8.21030175526727,0.8341106856063071,Pathogenic,0.999,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S241G,NP_000537:p.Ser241Gly,,,,,saturation_mutlist,,,,,,,,0.07675,-0.037240228652954094,,0.5568371273793197,,0.31679356368965983,,Neutral,Neutral,,Neutral,0.16892640680991827,,0.1597476582844099,0.01112,,0.4882973778444379,,0.24970868892221895,,Neutral,,Neutral,,0.18028789116915925,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.2896,0.0001,-22.239,-8.21030175526727,0.8691275895609734,Pathogenic,0.9958,pathogenic,-4.325,available,https://doi.org/10.1101/2022.10.22.513328 +S241H,NP_000537:p.Ser241His,,,,,saturation_mutlist,,,,,,,,0.72867,-0.06914067506790161,,-0.4596391698059869,,0.13451541509700657,,Neutral,Neutral,,Neutral,0.155181816021548,,0.05881422137902193,0.50993,,-0.45033877520054905,,0.029795612399725474,,Neutral,,Neutral,,0.11704646696266513,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3598,0.0001,-22.239,-8.21030175526727,0.8643708464289124,Pathogenic,0.9982,pathogenic,-4.548,available,https://doi.org/10.1101/2022.10.22.513328 +S241I,NP_000537:p.Ser241Ile,,,,,saturation_mutlist,,,,,,,,0.58016,0.6477275228500367,,-0.38611601995950284,,0.09702199002024858,,Neutral,Neutral,,Neutral,0.19205237255425855,,0.14132861468906385,0.52629,,-0.18476327395724393,,0.17076336302137807,,Neutral,,Neutral,,0.20708205784159872,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3617,0.0001,-22.239,-8.21030175526727,0.868601595457167,Pathogenic,0.9987,pathogenic,-4.617,available,https://doi.org/10.1101/2022.10.22.513328 +S241K,NP_000537:p.Ser241Lys,,,,,saturation_mutlist,,,,,,,,0.13348,0.28146096706390383,,-0.07091176225913133,,0.03128411887043433,,Neutral,Neutral,,Neutral,0.2012265119885459,,0.013846329680041148,0.14452,,-0.1527197131055863,,-0.0040998565527931435,,Neutral,,Neutral,,0.21416313066753215,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3691,0.0001,-22.239,-8.21030175526727,0.8670285198864858,Pathogenic,0.9998,pathogenic,-4.636,available,https://doi.org/10.1101/2022.10.22.513328 +S241L,NP_000537:p.Ser241Leu,,,,,saturation_mutlist,,,,,,,,-0.25972,0.4441107499599457,,-0.8718185151066029,,-0.5657692575533014,,Neutral,Neutral,,Neutral,0.23320043966843873,,0.2152247162283616,-0.0679,,-0.5741437959160389,,-0.32102189795801944,,Neutral,,Neutral,,0.21883177104827392,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3579,0.0001,-22.239,-8.21030175526727,0.8627464186620517,Pathogenic,0.9987,pathogenic,-4.464,available,https://doi.org/10.1101/2022.10.22.513328 +S241M,NP_000537:p.Ser241Met,,,,,saturation_mutlist,,,,,,,,-0.20035,0.272582973241806,,-0.4885337698528558,,-0.3444418849264279,,Neutral,Neutral,,Neutral,0.20085006222819024,,0.15992111734445985,0.05369,,-0.2013229475050754,,-0.07381647375253769,,Neutral,,Neutral,,0.2117725049285332,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.329,0.0001,-22.239,-8.21030175526727,0.859208432163286,Pathogenic,0.999,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328 +S241N,NP_000537:p.Ser241Asn,,,,,saturation_mutlist,,,,,,,,0.13178,-0.11351783514022826,,-0.3035377288022713,,-0.08587886440113565,,Neutral,Neutral,,Neutral,0.08870365739891556,,0.06969575451894022,0.10237,,-0.17950527111546286,,-0.038567635557731426,,Neutral,,Neutral,,0.1518878517732751,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3028,0.0001,-22.239,-8.21030175526727,0.86889986823361,Pathogenic,0.9995,pathogenic,-4.342,available,https://doi.org/10.1101/2022.10.22.513328 +S241P,NP_000537:p.Ser241Pro,"hg19,17:g.7577560A>G, hg19,17:g.7674242A>G, hg38,17:g.7674242A>G",,3.9764593606e-06,0.954,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376664,Uncertain significance,1,Likely oncogenic,1,Tier I - Strong,1,1.30996,0.9923497939109802,5.06746,2.1109571593956225,3.18871,1.7104585796978111,Uncertain,Uncertain,Neutral,Destabilizing,Neutral,0.24496349859038818,1.3192397069777224,1.1223569813274035,0.86339,5.001136666666667,1.8617539299024017,2.932263333333333,1.362571964951201,Uncertain,Neutral,Uncertain,Neutral,0.2763312090388795,0.5447159231360299,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.4339,0.0001,-22.239,-6.5576491183733,0.8708307029234279,Pathogenic,0.9981,pathogenic,-4.528,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S241Q,NP_000537:p.Ser241Gln,,,,,saturation_mutlist,,,,,,,,-0.01459,0.15328131914138793,,-0.01965644876826247,,-0.017123224384131237,,Neutral,Neutral,,Neutral,0.1934798735932705,,0.11605599388490438,0.05354,,0.044043269271955926,,0.048791634635977965,,Neutral,,Neutral,,0.1424527352004101,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3224,0.0001,-22.239,-8.21030175526727,0.8673136522121623,Pathogenic,0.9989,pathogenic,-4.495,available,https://doi.org/10.1101/2022.10.22.513328 +S241R,NP_000537:p.Ser241Arg,,,,,saturation_mutlist,,,,,,,,0.14024,0.2810106146335602,,-0.3696855174326435,,-0.11472275871632175,,Neutral,Neutral,,Neutral,0.17817349231641452,,0.08658961515252558,0.21793,,-0.3540408635049894,,-0.0680554317524947,,Neutral,,Neutral,,0.21884501036240928,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3743,0.0001,-22.239,-8.21030175526727,0.8464981781881484,Pathogenic,0.9996,pathogenic,-4.514,available,https://doi.org/10.1101/2022.10.22.513328 +S241T,NP_000537:p.Ser241Thr,"hg19,17:g.7577560A>T, hg38,17:g.7674242A>T",,,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",959232,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,0.47757,0.22912723779678346,-0.018139999999999993,0.05457750639266513,0.229715,0.2660737531963326,Neutral,Neutral,Neutral,Neutral,Neutral,0.10952703672064788,0.08719464547780442,0.08457992248286379,0.5541,-0.3680266666666667,0.022272002046884398,0.09303666666666666,0.2881860010234422,Neutral,Neutral,Neutral,Neutral,0.2741354436932388,0.16101219871546926,53.292,15.473,86.04,13.604,,False,53.292,,neutral,,,,False,86.04,,neutral,,,neutral,,-0.2712,0.0001,-22.239,-4.08804575809013,0.0750676283512807,Benign,0.9465,pathogenic,-3.75,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S241V,NP_000537:p.Ser241Val,,,,,"COSMIC,saturation_mutlist",,,,,,,,0.98158,0.6249200916290283,0.5060066666666666,-0.24287338748874454,0.7437933333333333,0.36935330625562773,Neutral,Neutral,Neutral,Neutral,Neutral,0.19059407637520093,0.2044033250436227,0.15612245964485374,0.71937,0.26406,-0.07959902594683503,0.491715,0.3198854870265825,Neutral,Neutral,Neutral,Neutral,0.6274848184617696,0.19259226241042568,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3359,0.0001,-22.239,-8.21030175526727,0.8384857362251064,Pathogenic,0.9989,pathogenic,-4.484,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S241W,NP_000537:p.Ser241Trp,,,,,saturation_mutlist,,,,,,,,0.82793,0.020969684123992915,,-0.9776766472589257,,-0.0748733236294628,,Neutral,Neutral,,Neutral,0.14552352924155018,,0.25221879111265627,0.48216,,-0.8486878557126917,,-0.18326392785634585,,Neutral,,Neutral,,0.12793493106874623,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3682,0.0001,-22.239,-8.21030175526727,0.8704042824955825,Pathogenic,0.9954,pathogenic,-4.702,available,https://doi.org/10.1101/2022.10.22.513328 +S241Y,NP_000537:p.Ser241Tyr,"hg19,17:g.7577559G>T, hg19,17:g.7674241G>T, hg38,17:g.7674241G>T",,,0.960,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376663,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,0.34905,-0.03781437635421754,-0.10340333333333333,-0.4448439234607375,0.12282333333333334,-0.047896961730368726,Neutral,Neutral,Neutral,Neutral,Neutral,0.19325486447476492,0.2913631381779255,0.16055582614345354,0.27899,-0.48095333333333334,-0.38536328650711565,-0.10098166666666666,-0.05318664325355782,Neutral,Neutral,Neutral,Neutral,0.23471110431526004,0.12186501333351263,53.292,15.473,86.04,13.604,,False,53.292,,uncertain,,,,False,86.04,,uncertain,,,neutral,,-0.3633,0.0001,-22.239,-8.21030175526727,0.8662815261164071,Pathogenic,0.9984,pathogenic,-4.623,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C242A,NP_000537:p.Cys242Ala,,,,,saturation_mutlist,,,,,,,,-0.15029,0.31019977807998655,,-0.15116802111241615,,-0.15072901055620808,,Neutral,Neutral,,Neutral,0.20238312045240106,,0.2662144096852397,2.00756,,-0.43902870301603186,,0.784265648491984,,Uncertain,,Neutral,,0.08977075436058318,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.4925,0.0001,-22.2361,-4.89657711428234,0.8570630110591773,Pathogenic,0.9992,pathogenic,-4.82,available,https://doi.org/10.1101/2022.10.22.513328 +C242D,NP_000537:p.Cys242Asp,,,,,saturation_mutlist,,,,,,,,-0.62065,0.08251024007797242,,-0.26734562115285465,,-0.44399781057642734,,Neutral,Neutral,,Neutral,0.3302620843868518,,0.32060207583580713,0.7981,,0.36401157314545746,,0.5810557865727287,,Neutral,,Neutral,,0.18149693258542504,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,uncertain,,-0.5997,0.0001,-22.2361,-6.98373917109865,0.7096340668085412,Pathogenic,0.997,pathogenic,-4.626,available,https://doi.org/10.1101/2022.10.22.513328 +C242E,NP_000537:p.Cys242Glu,,,,,saturation_mutlist,,,,,,,,-0.30954,0.8565610766410827,,-0.030258176502692663,,-0.1698990882513463,,Neutral,Neutral,,Neutral,0.24859824468612898,,0.21634933624600342,2.94346,,0.18067465745101388,,1.562067328725507,,Uncertain,,Neutral,,0.1454706070978414,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.5874,0.0001,-22.2361,-7.61266223783693,0.8541913809997577,Pathogenic,0.9999,pathogenic,-4.986,available,https://doi.org/10.1101/2022.10.22.513328 +C242F,NP_000537:p.Cys242Phe,"hg19,17:g.7577555_7577556delinsAA, hg19,17:g.7577556C>A, hg19,17:g.7674238C>A, hg38,17:g.7674237_7674238delinsAA, hg38,17:g.7674238C>A",,,0.977,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376578,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,-0.44315,0.670980851650238,1.1470533333333333,-0.3259029660520006,0.35195166666666666,-0.3845264830260003,Neutral,Neutral,Neutral,Neutral,Neutral,0.219181807169739,1.3499072884296741,0.32702149302684697,25.57796,0.0538566666666667,-0.5277254955337872,12.815908333333335,12.525117252233107,Uncertain,Uncertain,Destabilizing,Destabilizing,1.0911173722483856,0.49801759143780655,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.4865,0.0001,-22.2361,-8.15974944450928,0.8364706641668469,Pathogenic,0.9994,pathogenic,-4.749,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C242G,NP_000537:p.Cys242Gly,"hg19,17:g.7577557A>C, hg19,17:g.7674239A>C, hg38,17:g.7674239A>C",,,0.963,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376581,Conflicting classifications of pathogenicity,1,,,,,0.12598,0.4332521939277649,1.1863933333333332,0.8792643026328403,0.6561866666666666,0.5026221513164202,Neutral,Neutral,Neutral,Neutral,Neutral,0.41910320314954663,0.40988852926402103,0.33087205750011994,0.6299,1.8536299999999999,0.8315411117897757,1.241765,0.7307205558948879,Neutral,Neutral,Neutral,Neutral,0.1608840988620897,0.1565370720629161,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.4849,0.0001,-22.2361,-8.15974944450928,0.8636133106513612,Pathogenic,0.9973,pathogenic,-4.748,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C242H,NP_000537:p.Cys242His,,,,,saturation_mutlist,,,,,,,,0.31977,0.4688743042945862,,-0.3433894812259206,,-0.011809740612960307,,Neutral,Neutral,,Neutral,0.216096742625671,,0.2731604321190412,22.04444,,-0.1994381495982833,,10.92250092520086,,Uncertain,,Destabilizing,,0.20943144654712503,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.5982,0.0001,-22.2361,-8.15974944450928,0.8630796700660601,Pathogenic,0.9995,pathogenic,-4.845,available,https://doi.org/10.1101/2022.10.22.513328 +C242I,NP_000537:p.Cys242Ile,,,,,saturation_mutlist,,,,,,,,1.76699,0.6735406637191772,,-0.06731427614846668,,0.8498378619257667,,Neutral,Neutral,,Neutral,0.28872283560280737,,0.18197407682125633,9.77993,,-0.2626756579601462,,4.758627171019927,,Uncertain,,Destabilizing,,0.45708015479853265,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.5163,0.0001,-22.2361,-8.15974944450928,0.8578664956517759,Pathogenic,0.9998,pathogenic,-4.967,available,https://doi.org/10.1101/2022.10.22.513328 +C242K,NP_000537:p.Cys242Lys,,,,,saturation_mutlist,,,,,,,,-0.17888,0.8340089344978332,,0.5643799887624369,,0.19274999438121843,,Neutral,Neutral,,Neutral,0.20907159323924213,,0.21581559318648333,10.88222,,0.4144343517792107,,5.648327175889605,,Uncertain,,Destabilizing,,0.31273343271996235,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.588,0.0001,-22.2361,-8.15974944450928,0.8421538117312469,Pathogenic,1.0,pathogenic,-4.9,available,https://doi.org/10.1101/2022.10.22.513328 +C242L,NP_000537:p.Cys242Leu,,,,,saturation_mutlist,,,,,,,,-0.56604,0.7238545346260071,,-0.4869440639624197,,-0.5264920319812099,,Neutral,Neutral,,Neutral,0.2070376041474268,,0.31770805359713533,8.90203,,-0.9792899005245332,,3.9613700497377335,,Uncertain,,Destabilizing,,0.43954790450487347,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.5494,0.0001,-22.2361,-8.15974944450928,0.8353222406037167,Pathogenic,0.9992,pathogenic,-4.894,available,https://doi.org/10.1101/2022.10.22.513328 +C242M,NP_000537:p.Cys242Met,,,,,saturation_mutlist,,,,,,,,-0.63916,0.5546933388710023,,-0.15852875251650986,,-0.3988443762582549,,Neutral,Neutral,,Neutral,0.20812548250791751,,0.3319541637276839,7.41881,,-0.6400288373973825,,3.3893905813013085,,Uncertain,,Destabilizing,,0.38771033695542784,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.5166,0.0001,-22.2361,-8.15974944450928,0.8708131135071031,Pathogenic,0.9996,pathogenic,-4.969,available,https://doi.org/10.1101/2022.10.22.513328 +C242N,NP_000537:p.Cys242Asn,,,,,saturation_mutlist,,,,,,,,-0.22455,-0.018771960735321037,,-0.44904205918454304,,-0.3367960295922715,,Neutral,Neutral,,Neutral,0.364230227083995,,0.34796219703696873,6.38657,,-0.0937394602700279,,3.146415269864986,,Uncertain,,Destabilizing,,0.16220254256853664,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.5421,0.0001,-22.2361,-7.61266223783693,0.8699246610091091,Pathogenic,0.9997,pathogenic,-4.892,available,https://doi.org/10.1101/2022.10.22.513328 +C242P,NP_000537:p.Cys242Pro,,,,,saturation_mutlist,,,,,,,,5.80427,1.7155937767028808,,4.381900557448996,,5.093085278724498,,Destabilizing,Uncertain,,Destabilizing,0.3789589222082588,,0.6530071981622814,12.00085,,5.574421403546371,,8.787635701773185,,Destabilizing,,Destabilizing,,0.7479326048900892,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,uncertain,,-0.6108,0.0001,-22.2361,-8.15974944450928,0.8640514187010842,Pathogenic,0.9997,pathogenic,-4.914,available,https://doi.org/10.1101/2022.10.22.513328 +C242Q,NP_000537:p.Cys242Gln,,,,,saturation_mutlist,,,,,,,,0.09321,0.6906709218025208,,0.037517520238409284,,0.06536376011920464,,Neutral,Neutral,,Neutral,0.2609454304067966,,0.2919009957943325,8.17472,,-0.06552536380237188,,4.054597318098814,,Uncertain,,Destabilizing,,0.289401251144301,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.5661,0.0001,-22.2361,-7.61266223783693,0.8706917840866089,Pathogenic,0.9999,pathogenic,-4.946,available,https://doi.org/10.1101/2022.10.22.513328 +C242R,NP_000537:p.Cys242Arg,"hg19,17:g.7577557A>G, hg19,17:g.7674239A>G, hg38,17:g.7674239A>G",,,0.966,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",449512,Conflicting classifications of pathogenicity,1,,,,,0.08647,0.7933859181404114,0.2880933333333333,0.1568611904675887,0.18728166666666665,0.12166559523379436,Neutral,Neutral,Neutral,Neutral,Neutral,0.19164442195219583,0.1077336785266747,0.20561518527942504,12.41415,1.2206366666666668,-0.22482768401629458,6.817393333333333,6.094661157991853,Uncertain,Uncertain,Destabilizing,Destabilizing,0.4665202615345042,0.3149389610532679,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.5447,0.0001,-22.2361,-8.15974944450928,0.8339916451547135,Pathogenic,0.9994,pathogenic,-4.628,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C242S,NP_000537:p.Cys242Ser,"hg19,17:g.7577555_7577556delinsCG, hg19,17:g.7577555_7577556delinsTG, hg19,17:g.7577556C>G, hg19,17:g.7577557A>T, hg19,17:g.7674238C>G, hg19,17:g.7674239A>T, hg38,17:g.7674237_7674238delinsCG, hg38,17:g.7674237_7674238delinsTG, hg38,17:g.7674238C>G, hg38,17:g.7674239A>T",,,"0.947, 0.960","cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","2124706, 647334, 376579","Uncertain significance, Conflicting classifications of pathogenicity, Conflicting classifications of pathogenicity","1, 1, 1",,,Tier I - Strong,1,-0.16276,-0.18606430768966675,0.5776633333333333,0.09153790047834709,0.20745166666666665,-0.03561104976082645,Neutral,Neutral,Neutral,Neutral,Neutral,0.37264687898518045,1.2573340477993729,0.2629825017644667,2.5679,0.61508,0.3619960144770921,1.5914899999999998,1.464948007238546,Uncertain,Uncertain,Neutral,Neutral,0.10219824395099293,0.0664698079924501,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.4833,0.0001,-22.2361,-3.52762339560825,0.8694505454316817,Pathogenic,0.9989,pathogenic,-4.542,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C242T,NP_000537:p.Cys242Thr,,,,,saturation_mutlist,,,,,,,,0.79066,0.7362846159934997,,-0.019369656785787993,,0.38564517160710604,,Neutral,Neutral,,Neutral,0.28962472261567934,,0.2655161337332942,6.78461,,0.07055184538511096,,3.4275809226925555,,Uncertain,,Destabilizing,,0.16393403584210262,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.5179,0.0001,-22.2361,-4.89657711428234,0.856651120123094,Pathogenic,0.9996,pathogenic,-4.9,available,https://doi.org/10.1101/2022.10.22.513328 +C242V,NP_000537:p.Cys242Val,,,,,saturation_mutlist,,,,,,,,1.66749,0.8125414514541626,,-0.20327182774793304,,0.7321090861260334,,Neutral,Neutral,,Neutral,0.25140116470907836,,0.21081041814635204,7.90787,,-0.3033459416455015,,3.8022620291772493,,Uncertain,,Destabilizing,,0.32777937961034764,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.5144,0.0001,-22.2361,-8.15974944450928,0.8640438620631794,Pathogenic,0.9992,pathogenic,-4.865,available,https://doi.org/10.1101/2022.10.22.513328 +C242W,NP_000537:p.Cys242Trp,"hg19,17:g.7577555G>C, hg19,17:g.7674237G>C, hg38,17:g.7674237G>C",,,0.940,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376580,Pathogenic,1,,,,,0.72776,0.6282335138320922,-0.20997999999999997,-0.5307803352839798,0.25889,0.09848983235801007,Neutral,Neutral,Neutral,Neutral,Neutral,0.27833235681892254,1.3918417512298829,0.28332457400056454,29.24155,0.40736999999999995,-0.7893318523792411,14.82446,14.22610907381038,Uncertain,Uncertain,Destabilizing,Destabilizing,1.2459793874967058,0.4089343067701512,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.4896,0.0001,-22.2361,-8.15974944450928,0.8580461411782445,Pathogenic,0.9994,pathogenic,-4.76,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C242Y,NP_000537:p.Cys242Tyr,"hg19,17:g.7577555_7577556delinsAT, hg19,17:g.7577556C>T, hg19,17:g.7674238C>T, hg38,17:g.7674238C>T",,0.0,0.973,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12354,Pathogenic/Likely pathogenic,2,,,,,-0.24036,0.771345796585083,0.9043066666666668,-0.12854439284551786,0.3319733333333334,-0.18445219642275892,Neutral,Neutral,Neutral,Neutral,Neutral,0.27132439764733546,2.6040831126819968,0.3205324650475956,30.71702,0.6841233333333333,-0.20419899359708302,15.700571666666667,15.25641050320146,Uncertain,Uncertain,Destabilizing,Destabilizing,0.5947367306258758,0.35779631868631834,24.171,6.687,7.025,4.199,,False,24.171,,neutral,neutral,neutral,,False,7.025,,neutral,neutral,neutral,neutral,,-0.4958,0.0001,-22.2361,-8.15974944450928,0.8636054991225652,Pathogenic,0.9995,pathogenic,-4.664,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243A,NP_000537:p.Met243Ala,,,,,saturation_mutlist,,,,,,,,0.43844,-0.05603511095046997,,0.7166052674067931,,0.5775226337033965,,Neutral,Neutral,,Neutral,0.1976036327000069,,0.21618064063491918,0.17393,,0.04199069503600442,,0.10796034751800221,,Neutral,,Neutral,,0.26422665036453374,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.3045,1.056,-22.239,-5.01571368090132,0.2705271604166983,Benign,0.9692,pathogenic,-3.732,available,https://doi.org/10.1101/2022.10.22.513328 +M243C,NP_000537:p.Met243Cys,,,,,saturation_mutlist,,,,,,,,0.45079,-0.5159185338020325,,1.251946789421637,,0.8513683947108185,,Neutral,Neutral,,Neutral,0.2670717203216068,,0.20696727795336808,0.26706,,0.7288265893945117,,0.49794329469725584,,Neutral,,Neutral,,0.2189081244470178,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.31,1.056,-22.239,-5.86290893037641,0.8105238359843054,Pathogenic,0.9876,pathogenic,-4.352,available,https://doi.org/10.1101/2022.10.22.513328 +M243D,NP_000537:p.Met243Asp,,,,,saturation_mutlist,,,,,,,,0.0847,0.19111148357391358,,0.6080810834721307,,0.34639054173606537,,Neutral,Neutral,,Neutral,0.4523847892731164,,0.31984387607464415,-0.2041,,-0.27225018356310465,,-0.23817509178155233,,Neutral,,Neutral,,0.22735535377953164,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.416,1.056,-22.239,-6.44610485232603,0.8579453457228781,Pathogenic,0.9989,pathogenic,-4.56,available,https://doi.org/10.1101/2022.10.22.513328 +M243E,NP_000537:p.Met243Glu,,,,,saturation_mutlist,,,,,,,,0.07212,0.34072808265686033,,0.5429107918457886,,0.3075153959228943,,Neutral,Neutral,,Neutral,0.36769634784658334,,0.2649967648816641,-0.15618,,-0.2945183275280494,,-0.2253491637640247,,Neutral,,Neutral,,0.24733238637642327,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.4062,1.056,-22.239,-6.23220005976754,0.5954049090747371,Uncertain,0.9884,pathogenic,-4.275,available,https://doi.org/10.1101/2022.10.22.513328 +M243F,NP_000537:p.Met243Phe,,,,,saturation_mutlist,,,,,,,,0.09389,-0.23654983282089234,,0.06684216821308596,,0.08036608410654297,,Neutral,Neutral,,Neutral,0.19395874091556006,,0.27530992143959493,0.02308,,-0.19571922672423345,,-0.08631961336211673,,Neutral,,Neutral,,0.2125356464826109,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.3096,1.056,-22.239,-6.43544119380032,0.7764778081234568,Pathogenic,0.9189,pathogenic,-3.902,available,https://doi.org/10.1101/2022.10.22.513328 +M243G,NP_000537:p.Met243Gly,,,,,saturation_mutlist,,,,,,,,0.52342,0.48660727620124816,,1.1507221092035078,,0.8370710546017539,,Neutral,Neutral,,Neutral,0.36333412384040387,,0.32635278091897857,0.19075,,0.5527106727738375,,0.3717303363869187,,Neutral,,Neutral,,0.32816324872209485,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.3854,1.056,-22.239,-7.47274803967824,0.7877971953762282,Pathogenic,0.9883,pathogenic,-4.164,available,https://doi.org/10.1101/2022.10.22.513328 +M243H,NP_000537:p.Met243His,,,,,saturation_mutlist,,,,,,,,0.50409,-0.043252578973770134,,0.2512181270994935,,0.37765406354974673,,Neutral,Neutral,,Neutral,0.17980208301429443,,0.2458902304545837,0.30457,,-0.36624799867668595,,-0.03083899933834297,,Neutral,,Neutral,,0.22180023438369925,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.3628,1.056,-22.239,-6.24617069068418,0.6912580603964245,Pathogenic,0.989,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328 +M243I,NP_000537:p.Met243Ile,"hg19,17:g.7577552C>A, hg19,17:g.7577552C>G, hg19,17:g.7577552C>T, hg19,17:g.7674234C>A, hg38,17:g.7674234C>A, hg38,17:g.7674234C>G, hg38,17:g.7674234C>T",,,0.820,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",840505,Uncertain significance,1,,,,,0.40819,-0.038872625827789276,0.5088400000000001,0.30927543494475535,0.458515,0.35873271747237767,Neutral,Neutral,Neutral,Neutral,Neutral,0.10722934312367949,0.1263758096578086,0.2117405758997888,0.07268,0.021426666666666667,-0.23288143713613377,0.04705333333333333,-0.08010071856806689,Neutral,Neutral,Neutral,Neutral,0.14128526375937286,0.18576379598021145,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.2218,1.056,-22.239,-3.86249283957872,0.3689489737561906,Uncertain,0.9829,pathogenic,-3.65,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243K,NP_000537:p.Met243Lys,"hg38,17:g.7674235A>T",,,0.933,"COSMIC,saturation_mutlist",,,,,,,,0.06919,0.31452614545822144,0.20804999999999998,0.5161961481388934,0.13862,0.29269307406944667,Neutral,Neutral,Neutral,Neutral,Neutral,0.32303160977332046,0.2313186569792127,0.25151360636088804,0.03901,0.048186666666666676,-0.13452694139155638,0.043598333333333336,-0.04775847069577819,Neutral,Neutral,Neutral,Neutral,0.5041443358360337,0.26457032605491315,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.2993,1.056,-8.9511,-4.97557790620836,0.3794462245046546,Uncertain,0.9506,pathogenic,-4.159,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243L,NP_000537:p.Met243Leu,"hg19,17:g.7577554T>A, hg19,17:g.7577554T>G, hg38,17:g.7674236T>A, hg38,17:g.7674236T>G",,,0.763,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","1758050, 186653","Uncertain significance, Uncertain significance","2, 2",,,,,0.00618,0.02699368715286254,-0.08820666666666666,-0.15212472650398953,-0.041013333333333325,-0.07297236325199477,Neutral,Neutral,Neutral,Neutral,Neutral,0.1021715035480975,0.1900924863206212,0.19794320135273197,0.01141,0.06236,-0.5306106692612022,0.036885,-0.25960033463060106,Neutral,Neutral,Neutral,Neutral,0.29055473747069877,0.18359689244316313,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.1159,1.056,-7.9512,-0.913223744175104,0.2504216310607752,Benign,0.6754,pathogenic,-3.49,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243N,NP_000537:p.Met243Asn,,,,,saturation_mutlist,,,,,,,,0.30332,0.20482060551643372,,0.5139112754611025,,0.4086156377305512,,Neutral,Neutral,,Neutral,0.37753779122269554,,0.23295338232559806,0.0914,,-0.1576971764273329,,-0.03314858821366646,,Neutral,,Neutral,,0.2073788911828724,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.3576,1.056,-22.239,-5.8668624069445,0.4125255062321469,Uncertain,0.9802,pathogenic,-4.138,available,https://doi.org/10.1101/2022.10.22.513328 +M243P,NP_000537:p.Met243Pro,,,,,saturation_mutlist,,,,,,,,-0.25314,-0.15600044131278992,,1.1677006797498677,,0.4572803398749339,,Neutral,Neutral,,Neutral,0.35213471879668434,,0.28199989973056283,-0.23933,,0.9162851425888284,,0.33847757129441425,,Neutral,,Neutral,,0.5400854431368367,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.4755,1.056,-22.239,-5.00011910575688,0.3867947875803377,Uncertain,0.9751,pathogenic,-3.872,available,https://doi.org/10.1101/2022.10.22.513328 +M243Q,NP_000537:p.Met243Gln,,,,,saturation_mutlist,,,,,,,,0.16947,0.24070096731185914,,0.5866414788862387,,0.3780557394431194,,Neutral,Neutral,,Neutral,0.2883684662773051,,0.24280565223508246,0.07822,,0.01503475998935506,,0.04662737999467753,,Neutral,,Neutral,,0.20022226654222777,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.2819,1.056,-8.9511,-4.5712167623987,0.0359161187859434,Benign,0.8333,pathogenic,-3.804,available,https://doi.org/10.1101/2022.10.22.513328 +M243R,NP_000537:p.Met243Arg,"hg38,17:g.7674235A>C",,,0.890,"COSMIC,saturation_mutlist",,,,,,,,0.24464,0.3664478158950806,0.3921766666666667,0.2839413103632764,0.31840833333333335,0.2642906551816382,Neutral,Neutral,Neutral,Neutral,Neutral,0.33454791955403695,0.45235691110253007,0.20919874155395135,0.16253,0.47108666666666665,-0.2593239089435301,0.31680833333333336,-0.048396954471765036,Neutral,Neutral,Neutral,Neutral,0.4411315345285979,0.2260701551274679,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.3944,1.056,-22.239,-4.9510398083182,0.5258169918636857,Uncertain,0.9493,pathogenic,-3.996,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243S,NP_000537:p.Met243Ser,,,,,saturation_mutlist,,,,,,,,0.46785,-0.04458909988403319,,0.7845242322241358,,0.6261871161120679,,Neutral,Neutral,,Neutral,0.23204282309769989,,0.2747522532491531,0.35347,,-0.027763401215913735,,0.16285329939204313,,Neutral,,Neutral,,0.2560669774491935,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.3359,1.056,-22.239,-5.13576018958961,0.4946064661989386,Uncertain,0.9552,pathogenic,-3.831,available,https://doi.org/10.1101/2022.10.22.513328 +M243T,NP_000537:p.Met243Thr,"hg19,17:g.7577553A>G, hg38,17:g.7674234_7674235inv, hg38,17:g.7674235A>G",,,0.879,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182936,Conflicting classifications of pathogenicity,1,,,,,0.76461,0.2722668039798737,0.22290333333333331,0.6325246620522681,0.4937566666666667,0.698567331026134,Neutral,Neutral,Neutral,Neutral,Neutral,0.26185405346965435,0.17273407796057177,0.17384040388545782,0.22215,0.40079000000000004,0.026421258226422106,0.31147,0.12428562911321105,Neutral,Neutral,Neutral,Neutral,0.6210535515289054,0.2337517019091794,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.2757,1.056,-22.239,-5.0814076128431,0.1530788127335997,Benign,0.9711,pathogenic,-3.612,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243V,NP_000537:p.Met243Val,"hg19,17:g.7577554T>C, hg38,17:g.7674236T>C",,,0.705,"COSMIC,ClinVar,saturation_mutlist",406567,Conflicting classifications of pathogenicity,1,,,,,0.60759,0.16132548093795776,0.5524933333333334,0.45733019809154274,0.5800416666666667,0.5324600990457713,Neutral,Neutral,Neutral,Neutral,Neutral,0.1755810237711607,0.22701249016053918,0.14975917659970683,0.16842,0.15442,-0.1185930377776671,0.16142,0.024913481111166445,Neutral,Neutral,Neutral,Neutral,0.1995198641739714,0.18874800441812947,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.1445,1.056,-0.8117,-2.65749508073715,0.0642609487038819,Benign,0.6734,pathogenic,-3.246,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243W,NP_000537:p.Met243Trp,,,,,saturation_mutlist,,,,,,,,0.34254,-0.2335086178779602,,-0.13153983439592176,,0.10550008280203912,,Neutral,Neutral,,Neutral,0.14089613227346942,,0.2751005041607471,0.18482,,-0.5237383858724362,,-0.16945919293621808,,Neutral,,Neutral,,0.20045115549156722,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.3724,1.056,-22.239,-5.41958305366638,0.8657860349896072,Pathogenic,0.9905,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +M243Y,NP_000537:p.Met243Tyr,,,,,saturation_mutlist,,,,,,,,0.15824,-0.19670903205871582,,0.1998323620536,,0.1790361810268,,Neutral,Neutral,,Neutral,0.1043799999413955,,0.2793532903284222,0.0867,,-0.17037046610666903,,-0.04183523305333452,,Neutral,,Neutral,,0.21405867106426052,69.902,10.472,90.02,10.511,,False,69.902,,neutral,neutral,neutral,,False,90.02,,neutral,neutral,neutral,uncertain,,-0.3519,1.056,-22.239,-6.67656174183469,0.814276216251737,Pathogenic,0.9881,pathogenic,-4.19,available,https://doi.org/10.1101/2022.10.22.513328 +G244A,NP_000537:p.Gly244Ala,"hg19,17:g.7577550C>G, hg19,17:g.7674232C>G, hg38,17:g.7674232C>G",,,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458560,Pathogenic/Likely pathogenic,2,,,,,0.25822,-0.1567975687980652,0.3978466666666667,0.20314878710818352,0.32803333333333334,0.23068439355409176,Neutral,Neutral,Neutral,Neutral,Neutral,0.5792044457064152,0.7444139464184037,0.6360225383868091,2.86377,2.0216566666666664,1.441132416167295,2.4427133333333333,2.1524512080836473,Uncertain,Uncertain,Uncertain,Uncertain,0.8513548152340611,0.5306828174387204,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.3817,0.0211,-22.239,-6.16831376483764,0.7733710704049502,Pathogenic,0.9878,pathogenic,-4.14,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244C,NP_000537:p.Gly244Cys,"hg19,17:g.7577551C>A, hg19,17:g.7674233C>A, hg38,17:g.7674233C>A",,,0.940,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376599,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,0.49968,-0.5213437390327453,-0.0021533333333334514,0.6805500063776249,0.24876333333333328,0.5901150031888125,Neutral,Neutral,Neutral,Neutral,Neutral,0.6588778416001241,1.5606892503278442,0.5714138798727955,3.31566,3.3091866666666667,1.9737901642749174,3.3124233333333333,2.644725082137459,Destabilizing,Uncertain,Destabilizing,Uncertain,0.968728218244014,0.47880634276114536,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4415,0.0211,-22.239,-6.16831376483764,0.8500422283408849,Pathogenic,0.9978,pathogenic,-4.44,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244D,NP_000537:p.Gly244Asp,"hg19,17:g.7577550C>T, hg19,17:g.7674232C>T, hg38,17:g.7674232C>T",,,0.953,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",372785,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,0.80037,0.3428254124522209,-2.9137199999999996,0.0305078500797857,-1.0566749999999998,0.4154389250398929,Uncertain,Neutral,Neutral,Neutral,Neutral,0.6616507431430084,5.561384141188833,0.6175316844298622,2.83408,2.558733333333333,0.8694821707450576,2.6964066666666664,1.851781085372529,Uncertain,Uncertain,Uncertain,Neutral,1.2920738823130649,0.623231609194768,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.3742,0.0211,-8.9511,-7.29291234882808,0.0740398297691533,Benign,0.9987,pathogenic,-4.153,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244E,NP_000537:p.Gly244Glu,"hg38,17:g.7674231_7674232delinsTT",,,,"COSMIC,saturation_mutlist",,,,,,,,1.12659,0.590715848505497,-2.28651,0.21501045718832476,-0.5799599999999999,0.6708002285941623,Uncertain,Neutral,Neutral,Neutral,Neutral,0.5882071418445818,3.7026031699872997,0.8177520503806051,3.00218,1.25805,1.2750022722494103,2.130115,2.138591136124705,Uncertain,Uncertain,Uncertain,Uncertain,1.343199784122476,0.6895363277410158,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4413,0.0211,-22.239,-7.29291234882808,0.8168382547942192,Pathogenic,0.9993,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244F,NP_000537:p.Gly244Phe,"hg19,17:g.7577550_7577551delinsAA, hg38,17:g.7674232_7674233delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,3.4666,-0.164126877784729,-0.31054333333333334,-0.13649054060115293,1.5780283333333334,1.6650547296994236,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.6284715596853886,0.3323772870632943,0.813546479702188,3.31792,1.7630400000000002,0.9324813382122265,2.54048,2.125200669106113,Uncertain,Uncertain,Uncertain,Uncertain,1.2744659187544667,0.31439799408036617,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4796,0.0211,-22.239,-7.78169034861623,0.6673258987239299,Uncertain,0.9989,pathogenic,-4.502,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244H,NP_000537:p.Gly244His,,,,,saturation_mutlist,,,,,,,,3.64004,-0.042490162253379815,,-0.110403315065758,,1.7648183424671209,,Uncertain,Neutral,,Neutral,0.5749445875901269,,0.7731901548040537,3.77434,,0.6574674308300118,,2.215903715415006,,Uncertain,,Uncertain,,0.5110433401484432,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4543,0.0211,-22.239,-7.78169034861623,0.6218315206652222,Uncertain,0.9997,pathogenic,-4.517,available,https://doi.org/10.1101/2022.10.22.513328 +G244I,NP_000537:p.Gly244Ile,,,,,saturation_mutlist,,,,,,,,2.14276,0.19708943605422974,,0.46665776161066685,,1.3047088808053333,,Uncertain,Neutral,,Neutral,0.64710963378698,,0.9914743772350783,4.86735,,2.1000253061912275,,3.483687653095614,,Uncertain,,Destabilizing,,0.9052801607019343,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.5253,0.0211,-22.239,-7.51125204464897,0.8599543094008548,Pathogenic,0.9991,pathogenic,-4.626,available,https://doi.org/10.1101/2022.10.22.513328 +G244K,NP_000537:p.Gly244Lys,,,,,saturation_mutlist,,,,,,,,1.65905,0.5411496669054031,,0.4977953089207787,,1.0784226544603892,,Neutral,Neutral,,Neutral,0.4794068372723316,,0.9400337259268076,3.02774,,1.1131291581337577,,2.070434579066879,,Uncertain,,Uncertain,,0.6162328760422143,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4742,0.0211,-22.239,-8.0521286525835,0.3524255528866486,Uncertain,0.9997,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328 +G244L,NP_000537:p.Gly244Leu,,,,,saturation_mutlist,,,,,,,,0.27478,0.3331435126066208,,-0.19952805996987863,,0.0376259700150607,,Neutral,Neutral,,Neutral,0.4856721161397734,,0.8063816664625179,3.20109,,0.9136452373236184,,2.057367618661809,,Uncertain,,Uncertain,,0.4899368226067823,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4935,0.0211,-22.239,-6.98400098512006,0.6287823896698908,Uncertain,0.9985,pathogenic,-4.35,available,https://doi.org/10.1101/2022.10.22.513328 +G244M,NP_000537:p.Gly244Met,,,,,saturation_mutlist,,,,,,,,0.19676,0.2252096104621887,,0.03880009165926035,,0.11778004582963017,,Neutral,Neutral,,Neutral,0.4310912550171175,,0.736498529289198,2.8337,,1.091469133078099,,1.9625845665390496,,Uncertain,,Neutral,,0.4422336240597249,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4317,0.0211,-22.239,-7.51125204464897,0.7913737904473374,Pathogenic,0.9994,pathogenic,-4.44,available,https://doi.org/10.1101/2022.10.22.513328 +G244N,NP_000537:p.Gly244Asn,,,,,saturation_mutlist,,,,,,,,0.99808,0.18472645461559295,,0.015014625745198332,,0.5065473128725991,,Neutral,Neutral,,Neutral,0.6096271445904821,,0.5877370864187335,3.16316,,0.7473336891211563,,1.9552468445605782,,Uncertain,,Neutral,,0.5537665473099517,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4423,0.0211,-22.239,-7.29291234882808,0.7337909199878533,Pathogenic,0.9992,pathogenic,-4.294,available,https://doi.org/10.1101/2022.10.22.513328 +G244P,NP_000537:p.Gly244Pro,,,,,saturation_mutlist,,,,,,,,0.73194,0.34880790293216707,,3.125189486127985,,1.9285647430639927,,Uncertain,Neutral,,Neutral,0.7576194752391624,,0.8531858945507982,5.88736,,5.814461198213714,,5.850910599106857,,Destabilizing,,Destabilizing,,0.329265064375111,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.5394,0.0211,-22.239,-5.84144631749577,0.4529448455316377,Uncertain,0.9993,pathogenic,-4.13,available,https://doi.org/10.1101/2022.10.22.513328 +G244Q,NP_000537:p.Gly244Gln,,,,,saturation_mutlist,,,,,,,,1.32322,0.38115439653396604,,0.30362986844420065,,0.8134249342221004,,Neutral,Neutral,,Neutral,0.5052814410150175,,0.7809760142093112,3.18289,,1.4123760302798607,,2.2976330151399305,,Uncertain,,Uncertain,,0.5752210545400994,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4452,0.0211,-22.239,-7.02115582267965,0.6703850315558944,Uncertain,0.9995,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328 +G244R,NP_000537:p.Gly244Arg,"hg19,17:g.7577551C>G, hg19,17:g.7674233C>G, hg38,17:g.7674233C>G",,,0.942,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3634428,Uncertain significance,1,,,,,2.66996,0.5964634153246879,0.3257366666666667,0.21583504660568073,1.4978483333333334,1.4428975233028405,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.4177539435178355,0.6748578815490628,0.8912380904100254,3.15581,2.0257366666666665,0.9501946946249292,2.590773333333333,2.0530023473124643,Uncertain,Uncertain,Uncertain,Uncertain,1.0655004929244387,0.5221148285141382,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4583,0.0211,-22.239,-8.0521286525835,0.7856269786671234,Pathogenic,0.999,pathogenic,-4.24,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244S,NP_000537:p.Gly244Ser,"hg19,17:g.7577551C>T, hg19,17:g.7674233C>T, hg38,17:g.7674233C>T",,,0.936,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376600,Pathogenic,2,Oncogenic,1,Tier I - Strong,1,0.99881,-0.1387775206565857,-0.7967099999999999,0.2895353842703711,0.10105000000000003,0.6441726921351856,Neutral,Neutral,Neutral,Neutral,Neutral,0.6413679623190113,2.3796876999443994,0.5210328270716185,3.23345,2.03413,1.374344874960837,2.6337900000000003,2.303897437480418,Uncertain,Uncertain,Uncertain,Uncertain,1.286500937582247,0.5065843512570805,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.3876,0.0211,-22.239,-5.25612230183068,0.0181219299350898,Benign,0.9907,pathogenic,-3.724,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244T,NP_000537:p.Gly244Thr,,,,,saturation_mutlist,,,,,,,,1.99107,0.24543996632099152,,0.4720721756123318,,1.2315710878061659,,Neutral,Neutral,,Neutral,0.5329374383998932,,0.7768676203180865,5.05675,,2.03439272234021,,3.545571361170105,,Uncertain,,Destabilizing,,0.6587407303409992,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4645,0.0211,-22.239,-5.26165082957476,0.0659943532966623,Benign,0.9952,pathogenic,-3.977,available,https://doi.org/10.1101/2022.10.22.513328 +G244V,NP_000537:p.Gly244Val,"hg19,17:g.7577550C>A, hg19,17:g.7674232C>A, hg38,17:g.7674232C>A",,,0.949,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376601,Likely pathogenic,1,,,,,1.51192,0.216614248752594,-0.0986366666666667,0.39771052715750793,0.7066416666666666,0.9548152635787539,Neutral,Neutral,Neutral,Neutral,Neutral,0.6444769969090607,0.9326951922728502,0.8255558355021192,5.00087,4.67925,2.20854373545025,4.840059999999999,3.604706867725125,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.48768340939589067,0.8148119094016913,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4685,0.0211,-22.239,-7.51125204464897,0.8639126331446011,Pathogenic,0.9973,pathogenic,-4.394,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244W,NP_000537:p.Gly244Trp,,,,,saturation_mutlist,,,,,,,,6.01348,-0.0117500838637352,,-0.4869656479105897,,2.7632571760447053,,Uncertain,Neutral,,Uncertain,0.5566361078163322,,0.8681450661837371,3.61433,,0.5315820838332562,,2.072956041916628,,Uncertain,,Uncertain,,0.32430939787773855,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.4794,0.0211,-22.239,-7.78169034861623,0.854358503187032,Pathogenic,0.9984,pathogenic,-4.629,available,https://doi.org/10.1101/2022.10.22.513328 +G244Y,NP_000537:p.Gly244Tyr,,,,,saturation_mutlist,,,,,,,,4.35141,-0.14643518209457398,,-0.006962820103749119,,2.1722235899481253,,Uncertain,Neutral,,Uncertain,0.5878530993480273,,0.8437172433029654,3.38673,,1.0152474081126632,,2.2009887040563316,,Uncertain,,Uncertain,,0.34861202067939717,34.894,15.866,84.045,15.448,,False,34.894,,neutral,neutral,neutral,,False,84.045,,neutral,neutral,neutral,uncertain,,-0.48,0.0211,-22.239,-7.78169034861623,0.8365961555364605,Pathogenic,0.9986,pathogenic,-4.696,available,https://doi.org/10.1101/2022.10.22.513328 +G245A,NP_000537:p.Gly245Ala,"hg19,17:g.7577546_7577547delinsTG, hg19,17:g.7577547C>G, hg19,17:g.7674229C>G, hg38,17:g.7674229C>G",,,0.946,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",265357,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,1.1708,0.6293759965896606,0.25986333333333334,1.2965757723316915,0.7153316666666667,1.2336878861658458,Neutral,Neutral,Neutral,Neutral,Neutral,0.5198615071274496,1.0928996525248276,0.5113930938919674,4.08721,0.82585,0.13899084473317178,2.45653,2.113100422366586,Uncertain,Uncertain,Uncertain,Uncertain,0.47483163359939135,0.8783621532377277,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.3817,0.0211,-22.239,-7.14246254602009,0.7238127307313789,Pathogenic,0.9856,pathogenic,-4.158,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245C,NP_000537:p.Gly245Cys,"hg19,17:g.7577548C>A, hg19,17:g.7674230C>A, hg38,17:g.7674230C>A",,,0.970,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12349,Pathogenic,2,Oncogenic,1,Tier I - Strong,1,1.58996,0.4146981930732727,0.27211,2.004419146075962,0.9310350000000001,1.797189573037981,Neutral,Uncertain,Neutral,Neutral,Neutral,0.45430374831365694,1.0800868922761107,0.7323854220531292,6.75147,2.6841266666666663,1.1091612789233025,4.7177983333333335,3.9303156394616514,Uncertain,Uncertain,Destabilizing,Destabilizing,0.6379480971747535,1.5052290411191018,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.4415,0.0211,-22.239,-7.14246254602009,0.8675127486874716,Pathogenic,0.9965,pathogenic,-4.497,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245D,NP_000537:p.Gly245Asp,"hg19,17:g.7577546_7577547delinsAT, hg19,17:g.7577547C>T, hg19,17:g.7674229C>T, hg38,17:g.7674228_7674229delinsAT, hg38,17:g.7674229C>T",,3.9767123723e-06,0.974,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","861760, 12355","Pathogenic, Pathogenic/Likely pathogenic","1, 2",,,Tier I - Strong,1,3.81577,1.0045443880558014,-3.7723333333333335,2.291459378789201,0.021718333333333284,3.0536146893946006,Uncertain,Uncertain,Uncertain,Neutral,Destabilizing,0.37643870356625686,3.0043328720847313,0.8973780502414903,10.54465,1.9718833333333334,1.2790826090413587,6.2582666666666675,5.91186630452068,Uncertain,Uncertain,Destabilizing,Destabilizing,1.0377161180956742,2.027024552798811,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.442,0.0211,-22.239,-7.84612232477533,0.8583335949345794,Pathogenic,0.9989,pathogenic,-4.464,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245E,NP_000537:p.Gly245Glu,"hg38,17:g.7674228_7674229delinsTT",,,,"COSMIC,saturation_mutlist",,,,,,,,4.6487,1.2513176155090333,-2.14161,3.1012056267647226,1.253545,3.874952813382361,Uncertain,Destabilizing,Uncertain,Neutral,Destabilizing,0.3699479529242053,2.0365278938919547,0.8843400073144871,9.58635,3.032313333333333,1.5473021001161245,6.309331666666666,5.5668260500580615,Destabilizing,Uncertain,Destabilizing,Destabilizing,1.7631980309716269,2.3917368533106016,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.4413,0.0211,-22.239,-7.13690041857986,0.7365059112341075,Pathogenic,0.9993,pathogenic,-4.388,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245F,NP_000537:p.Gly245Phe,"hg19,17:g.7577547_7577548delinsAA, hg38,17:g.7674229_7674230delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,8.6301,0.6785773229598999,2.55964,2.306833937301402,5.59487,5.468466968650701,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,0.654640305023961,1.4661432829251944,1.0055829002142704,21.23627,7.951586666666667,0.25675739053866425,14.593928333333334,10.746513695269332,Destabilizing,Uncertain,Destabilizing,Destabilizing,4.231074589040262,1.9553819457599504,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.4796,0.0211,-22.239,-8.11833508552484,0.781670790278806,Pathogenic,0.9987,pathogenic,-4.456,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245H,NP_000537:p.Gly245His,"hg38,17:g.7674229_7674230delinsTG",,,,"COSMIC,saturation_mutlist",,,,,,,,9.71319,0.7982741928100586,-0.07131333333333335,2.2633665029766057,4.820938333333333,5.988278251488303,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,0.45186649382986266,0.3554723350073189,0.8931355071892109,23.539,6.4503433333333335,0.6008400059887538,14.994671666666667,12.069920002994378,Destabilizing,Uncertain,Destabilizing,Destabilizing,2.4395622955130474,1.9903066422276146,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.4543,0.0211,-22.239,-8.11833508552484,0.8548213574385146,Pathogenic,0.9997,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245I,NP_000537:p.Gly245Ile,"hg19,17:g.7577547_7577548delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,5.0696,1.1578620409965514,1.37551,3.127623220062349,3.2225550000000003,4.098611610031175,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.6075813244674533,1.4278799519800909,1.4479255877223591,14.0668,2.9823133333333334,1.1630096810848423,8.524556666666667,7.614904840542422,Uncertain,Uncertain,Destabilizing,Destabilizing,1.0514066009663223,2.4958894285761724,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.5253,0.0211,-22.239,-8.11833508552484,0.8649891575274022,Pathogenic,0.9986,pathogenic,-4.527,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245K,NP_000537:p.Gly245Lys,,,,,saturation_mutlist,,,,,,,,6.66745,1.123003170490265,,3.6418109674498207,,5.15463048372491,,Destabilizing,Uncertain,,Destabilizing,0.40037714769494365,,1.065791358850884,15.00345,,1.803865570328793,,8.403657785164397,,Uncertain,,Destabilizing,,2.340810389859475,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.4742,0.0211,-22.239,-7.6868880675191,0.8000943518903343,Pathogenic,0.9995,pathogenic,-4.444,available,https://doi.org/10.1101/2022.10.22.513328 +G245L,NP_000537:p.Gly245Leu,"hg38,17:g.7674229_7674230delinsAG",,,,"COSMIC,saturation_mutlist",,,,,,,,3.95163,1.129743111729622,3.563603333333333,2.2705354401849105,3.7576166666666664,3.1110827200924556,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.4343994624282649,0.6514441299826784,1.0505123921011714,12.55155,3.146713333333333,0.260502855392901,7.849131666666667,6.4060264276964505,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.46256741666005347,1.918713811096424,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.4935,0.0211,-22.239,-8.11833508552484,0.8678062587772928,Pathogenic,0.9988,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245M,NP_000537:p.Gly245Met,,,,,saturation_mutlist,,,,,,,,3.25906,0.9556184196472168,,2.454643441405644,,2.8568517207028217,,Uncertain,Neutral,,Uncertain,0.3840729442198118,,0.923345024541498,10.58685,,0.40921155294266826,,5.498030776471334,,Uncertain,,Destabilizing,,1.7962540612083568,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.4317,0.0211,-22.239,-8.11833508552484,0.8589987811206987,Pathogenic,0.9993,pathogenic,-4.565,available,https://doi.org/10.1101/2022.10.22.513328 +G245N,NP_000537:p.Gly245Asn,"hg19,17:g.7577547_7577548delinsTT, hg38,17:g.7674229_7674230delinsTT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,4.04982,0.9090666580200195,1.8078233333333333,1.7368978548383514,2.928821666666667,2.8933589274191758,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.40104928163226466,1.8853051469427673,0.762826675476502,10.90426,2.4984133333333336,0.769509972423533,6.701336666666667,5.836884986211767,Uncertain,Uncertain,Destabilizing,Destabilizing,0.8549618287515662,1.7812960030770806,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.4423,0.0211,-22.239,-7.84612232477533,0.863482507871034,Pathogenic,0.9988,pathogenic,-4.231,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245P,NP_000537:p.Gly245Pro,,,,,saturation_mutlist,,,,,,,,4.0513,1.2244555640220642,,5.98472012426393,,5.018010062131966,,Destabilizing,Uncertain,,Destabilizing,0.7136835031623439,,1.19311786525134,11.40068,,4.6614054983920985,,8.031042749196049,,Destabilizing,,Destabilizing,,2.5355643717754583,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.5394,0.0211,-22.239,-8.11833508552484,0.8599737772626729,Pathogenic,0.9998,pathogenic,-4.65,available,https://doi.org/10.1101/2022.10.22.513328 +G245Q,NP_000537:p.Gly245Gln,,,,,saturation_mutlist,,,,,,,,4.64763,1.0525202214717866,,2.942393584408865,,3.7950117922044324,,Uncertain,Uncertain,,Destabilizing,0.3569903243098552,,0.9342948056235686,11.58156,,1.125769915720806,,6.353664957860403,,Uncertain,,Destabilizing,,1.9841396775663198,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.4452,0.0211,-22.239,-7.84612232477533,0.8539753030692447,Pathogenic,0.9994,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +G245R,NP_000537:p.Gly245Arg,"hg19,17:g.7577548C>G, hg19,17:g.7674230C>G, hg38,17:g.7674230C>G",,0.0,0.961,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376604,Conflicting classifications of pathogenicity,1,,,,,8.23398,1.0997733306884765,-0.12278666666666682,2.8881029128570312,4.055596666666667,5.561041456428516,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.39632045816808525,2.889315156853302,1.1248179327639594,17.46891,5.514173333333333,1.2008724703593057,11.491541666666667,9.334891235179654,Destabilizing,Uncertain,Destabilizing,Destabilizing,3.8119003705442718,2.1930234472575862,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.3905,0.0211,-8.9511,-5.02711372287612,0.4241063623239255,Uncertain,0.9987,pathogenic,-4.402,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245S,NP_000537:p.Gly245Ser,"hg19,17:g.7577548C>T, hg19,17:g.7674230C>T, hg38,17:g.7674230C>T",3.19284802043e-05,0.0,0.947,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12365,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,1.75106,0.6795496392250061,0.43526333333333334,1.8977737259090717,1.0931616666666666,1.8244168629545359,Neutral,Neutral,Neutral,Neutral,Neutral,0.5620690857048902,0.7919415540022859,0.591512951999088,5.74996,1.6488666666666667,0.9861427214843114,3.699413333333333,3.3680513607421556,Uncertain,Uncertain,Destabilizing,Destabilizing,0.6599769339572069,1.372175281497342,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.3876,0.0211,-22.239,-5.81833350582095,0.0590408480555328,Benign,0.9732,pathogenic,-3.798,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245T,NP_000537:p.Gly245Thr,,,,,saturation_mutlist,,,,,,,,3.66059,0.9424191308021546,,2.3793879418084036,,3.019988970904202,,Uncertain,Neutral,,Destabilizing,0.6004843422234917,,0.9261877942616238,10.55051,,1.1206618242801447,,5.835585912140072,,Uncertain,,Destabilizing,,1.903976131849137,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.4645,0.0211,-22.239,-7.14246254602009,0.6191797514730958,Uncertain,0.9952,pathogenic,-4.278,available,https://doi.org/10.1101/2022.10.22.513328 +G245V,NP_000537:p.Gly245Val,"hg19,17:g.7577546_7577547delinsAA, hg19,17:g.7577547C>A, hg19,17:g.7674229C>A, hg38,17:g.7674228_7674229delinsAA, hg38,17:g.7674229C>A",,3.9767123723e-06,0.972,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376603,Pathogenic,2,Oncogenic,1,,,3.72793,1.1649422502517701,-0.7816299999999999,2.4373192549566807,1.4731500000000002,3.0826246274783404,Uncertain,Uncertain,Uncertain,Neutral,Destabilizing,0.577904121876553,1.1080436745002429,1.3381129928954927,11.44423,1.74796,0.851504503060824,6.596095,6.147867251530411,Uncertain,Uncertain,Destabilizing,Destabilizing,1.3643738846323124,2.2020858726843135,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.4685,0.0211,-22.239,-8.11833508552484,0.8486102610890538,Pathogenic,0.9969,pathogenic,-4.535,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245W,NP_000537:p.Gly245Trp,,,,,saturation_mutlist,,,,,,,,15.87155,0.7762492513656616,,2.6101858139854723,,9.240867906992737,,Uncertain,Neutral,,Destabilizing,0.63539169678066,,1.1290154759639093,30.50233,,0.1897617280802164,,15.346045864040109,,Uncertain,,Destabilizing,,1.9753355497147986,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.4794,0.0211,-22.239,-8.11833508552484,0.8432927137407036,Pathogenic,0.9986,pathogenic,-4.634,available,https://doi.org/10.1101/2022.10.22.513328 +G245Y,NP_000537:p.Gly245Tyr,"hg19,17:g.7577547_7577548delinsTA",,,,"cBioPortal,saturation_mutlist",,,,,,,,10.31766,0.7282335734367371,0.7275533333333333,2.6238642584758267,5.522606666666666,6.470762129237913,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,0.6715558627207064,1.0554564054895346,0.9882136035915253,24.57901,9.121653333333333,0.6037486483288649,16.850331666666666,12.591379324164432,Destabilizing,Uncertain,Destabilizing,Destabilizing,5.919608216350883,2.1060857363195082,14.521,11.562,14.415,17.839,,False,14.521,,neutral,neutral,neutral,,False,14.415,,neutral,neutral,neutral,uncertain,,-0.48,0.0211,-22.239,-8.11833508552484,0.8673725117607469,Pathogenic,0.9989,pathogenic,-4.711,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246A,NP_000537:p.Met246Ala,,,,,saturation_mutlist,,,,,,,,2.55586,1.1352103328704835,,2.20500503180584,,2.3804325159029203,,Uncertain,Uncertain,,Uncertain,0.30601973855617953,,0.12820895209432848,0.58343,,2.0275305141460893,,1.3054802570730446,,Uncertain,,Neutral,,0.3585728457953818,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.3997,0.0212,-22.2332,-7.57609653582207,0.8694803141701529,Pathogenic,0.9964,pathogenic,-4.262,available,https://doi.org/10.1101/2022.10.22.513328 +M246C,NP_000537:p.Met246Cys,,,,,saturation_mutlist,,,,,,,,2.30294,0.6635740685462952,,2.3484923461235927,,2.3257161730617963,,Uncertain,Neutral,,Uncertain,0.23167420748939258,,0.07307710648347972,0.62797,,2.3381139894581406,,1.4830419947290703,,Uncertain,,Neutral,,0.2298696546613342,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.4052,0.0212,-22.2332,-7.57609653582207,0.8507348962555651,Pathogenic,0.9961,pathogenic,-4.528,available,https://doi.org/10.1101/2022.10.22.513328 +M246D,NP_000537:p.Met246Asp,,,,,saturation_mutlist,,,,,,,,2.74402,1.6266804885864259,,3.031361874537575,,2.8876909372687876,,Uncertain,Uncertain,,Uncertain,0.3136210620250263,,0.22509960772552506,1.76672,,2.959453807487036,,2.363086903743518,,Uncertain,,Uncertain,,0.5402556618999028,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.5112,0.0212,-22.2332,-7.17281793689777,0.8699002421577389,Pathogenic,0.9998,pathogenic,-4.761,available,https://doi.org/10.1101/2022.10.22.513328 +M246E,NP_000537:p.Met246Glu,,,,,saturation_mutlist,,,,,,,,2.21265,1.6396273136138917,,2.761661543007653,,2.4871557715038266,,Uncertain,Uncertain,,Uncertain,0.18109092368068846,,0.10993385008978447,2.13572,,2.705442728826187,,2.420581364413094,,Uncertain,,Uncertain,,0.5495164333469024,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.5014,0.0212,-22.2332,-7.17281793689777,0.8708581528396837,Pathogenic,0.9982,pathogenic,-4.546,available,https://doi.org/10.1101/2022.10.22.513328 +M246F,NP_000537:p.Met246Phe,,,,,saturation_mutlist,,,,,,,,1.64984,0.47929856300354,,-0.07212301039279537,,0.7888584948036023,,Neutral,Neutral,,Neutral,0.3177198610385309,,0.3433325217126186,4.17913,,1.1976523693037764,,2.688391184651888,,Uncertain,,Uncertain,,1.0999507366226058,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.4048,0.0212,-22.2332,-6.91837746985783,0.8629994461885333,Pathogenic,0.9615,pathogenic,-4.336,available,https://doi.org/10.1101/2022.10.22.513328 +M246G,NP_000537:p.Met246Gly,,,,,saturation_mutlist,,,,,,,,3.31951,1.538923099040985,,3.777671013664451,,3.548590506832226,,Destabilizing,Uncertain,,Destabilizing,0.40972131641598475,,0.2599561261508432,0.41101,,3.424743457215501,,1.9178767286077505,,Uncertain,,Neutral,,0.42467338436956353,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.4806,0.0212,-22.2332,-7.57609653582207,0.8630812922548369,Pathogenic,0.9984,pathogenic,-4.444,available,https://doi.org/10.1101/2022.10.22.513328 +M246H,NP_000537:p.Met246His,,,,,saturation_mutlist,,,,,,,,2.53224,1.1738317823410034,,1.1168029984302856,,1.8245214992151428,,Uncertain,Uncertain,,Neutral,0.40938193470209694,,0.27367400261989205,4.66247,,1.9634927999009497,,3.3129813999504747,,Uncertain,,Destabilizing,,0.7802286008709995,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.458,0.0212,-22.2332,-6.28560768788161,0.6524611313234762,Uncertain,0.999,pathogenic,-4.046,available,https://doi.org/10.1101/2022.10.22.513328 +M246I,NP_000537:p.Met246Ile,"hg19,17:g.7577543C>A, hg19,17:g.7577543C>G, hg19,17:g.7577543C>T, hg19,17:g.7674225C>A, hg19,17:g.7674225C>G, hg19,17:g.7674225C>T, hg38,17:g.7674225C>A, hg38,17:g.7674225C>G, hg38,17:g.7674225C>T",,,0.838,"cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","1758655, 968639, 480961","Likely pathogenic, Conflicting classifications of pathogenicity, Pathogenic/Likely pathogenic","1, 1, 2",Oncogenic,1,,,2.25033,0.46008113145828244,0.9598666666666666,0.6187301187431914,1.6050983333333333,1.4345300593715957,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.38275310975176263,1.267664164262584,0.1399241642332954,2.2509,1.5056666666666665,1.1639889665888135,1.8782833333333333,1.707444483294407,Uncertain,Uncertain,Neutral,Neutral,0.8545550592884905,0.16166831604607057,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.2492,0.0212,-8.9453,-3.37572060739883,0.2999832334585663,Benign,0.9793,pathogenic,-3.636,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246K,NP_000537:p.Met246Lys,"hg19,17:g.7577544A>T, hg19,17:g.7674226A>T, hg38,17:g.7674226A>T",,,0.963,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480764,Likely pathogenic,2,,,,,3.035,1.5732671403884888,5.087413333333333,3.1219755632731077,4.061206666666667,3.0784877816365537,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.4163709098248519,1.3792999303108646,0.12906341140697775,2.8914,4.784013333333333,3.1345792176898493,3.8377066666666666,3.012989608844925,Uncertain,Uncertain,Destabilizing,Destabilizing,0.23828666018521125,0.9157337497588516,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.4623,0.0212,-22.2332,-7.57609653582207,0.8688500462607078,Pathogenic,0.9922,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246L,NP_000537:p.Met246Leu,"hg19,17:g.7577545T>A, hg19,17:g.7577545T>G, hg38,17:g.7674227T>A, hg38,17:g.7674227T>G",,,0.865,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","406586, 186737","Uncertain significance, Conflicting classifications of pathogenicity","1, 1",,,,,0.15461,0.010877230167388919,0.6765300000000001,-0.17371526967453432,0.41557000000000005,-0.009552634837267163,Neutral,Neutral,Neutral,Neutral,Neutral,0.2574869262520166,1.4002114224168674,0.08535517955261138,0.19238,1.1953500000000001,0.5816393889316824,0.6938650000000001,0.3870096944658412,Neutral,Neutral,Neutral,Neutral,1.123328826420237,0.4030310637336548,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.284,0.0212,-22.2332,-3.25823119973457,0.4449429887498569,Uncertain,0.8684,pathogenic,-3.535,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246N,NP_000537:p.Met246Asn,,,,,saturation_mutlist,,,,,,,,2.62501,1.4889934682846069,,1.9436002811887523,,2.284305140594376,,Uncertain,Uncertain,,Uncertain,0.3898761536019671,,0.1510182679454512,1.50333,,2.0558668409445766,,1.7795984204722883,,Uncertain,,Neutral,,0.3118990229126974,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.4528,0.0212,-22.2332,-7.17281793689777,0.8461018634662261,Pathogenic,0.9977,pathogenic,-4.506,available,https://doi.org/10.1101/2022.10.22.513328 +M246P,NP_000537:p.Met246Pro,,,,,saturation_mutlist,,,,,,,,1.18203,1.2327081966400146,,4.793504877903785,,2.9877674389518925,,Uncertain,Uncertain,,Uncertain,0.3410790483454766,,0.238763725896555,-0.00163,,5.112539763602516,,2.5554548818012583,,Uncertain,,Uncertain,,1.2914089337654564,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.5707,0.0212,-22.2332,-4.75677619411136,0.4173386498972297,Uncertain,0.9767,pathogenic,-3.864,available,https://doi.org/10.1101/2022.10.22.513328 +M246Q,NP_000537:p.Met246Gln,,,,,saturation_mutlist,,,,,,,,2.32928,1.1381149530410766,,1.848022453508661,,2.0886512267543305,,Uncertain,Uncertain,,Uncertain,0.24267179162032862,,0.07782240321977163,1.7377,,2.1446491851653446,,1.9411745925826724,,Uncertain,,Neutral,,0.43544913246822176,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.4449,0.0212,-22.2332,-6.33201696677918,0.8651390951041079,Pathogenic,0.9839,pathogenic,-4.056,available,https://doi.org/10.1101/2022.10.22.513328 +M246R,NP_000537:p.Met246Arg,"hg19,17:g.7577544A>C, hg19,17:g.7674226A>C, hg38,17:g.7674226A>C",,,0.959,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127822,Conflicting classifications of pathogenicity,1,,,,,4.31358,1.5328706622123718,4.522223333333334,2.124810558364562,4.417901666666667,3.219195279182281,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.4366346988941666,2.384529466740882,0.11612364455072222,4.89822,3.131066666666667,2.380872836069118,4.014643333333334,3.639546418034559,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.4432602403655091,0.7574463809695962,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.4896,0.0212,-22.2332,-7.57609653582207,0.8706269961166653,Pathogenic,0.9949,pathogenic,-4.442,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246S,NP_000537:p.Met246Ser,,,,,saturation_mutlist,,,,,,,,3.13494,1.3907541465759277,,2.911152646145874,,3.023046323072937,,Uncertain,Uncertain,,Destabilizing,0.36830512191833453,,0.14999662182394266,1.08805,,2.6669757499444606,,1.8775128749722303,,Uncertain,,Neutral,,0.4169796789088336,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.4311,0.0212,-22.2332,-7.57609653582207,0.8708481666523378,Pathogenic,0.9967,pathogenic,-4.372,available,https://doi.org/10.1101/2022.10.22.513328 +M246T,NP_000537:p.Met246Thr,"hg19,17:g.7577544A>G, hg19,17:g.7674226A>G, hg38,17:g.7674226A>G",,,0.956,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428886,Conflicting classifications of pathogenicity,1,,,,,3.28433,1.4524878001213073,2.3298200000000002,2.197538633718857,2.807075,2.7409343168594287,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.33061442206068975,0.663545447174997,0.12596467505794703,1.89946,2.8480733333333332,2.164471014397694,2.3737666666666666,2.031965507198847,Uncertain,Uncertain,Uncertain,Uncertain,0.5998126434331159,0.2517054540968975,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.3709,0.0212,-22.2332,-7.57609653582207,0.8655652021841689,Pathogenic,0.9983,pathogenic,-4.167,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246V,NP_000537:p.Met246Val,"hg19,17:g.7577545T>C, hg19,17:g.7674227T>C, hg38,17:g.7674227T>C",,,0.924,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",100815,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,2.76279,0.9776238536834717,1.42415,1.0258691758173513,2.09347,1.8943295879086754,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.3175573340032055,0.9615295739948235,0.0366656652908196,1.47162,2.3336733333333335,1.3117062623004225,1.9026466666666666,1.3916631311502112,Uncertain,Neutral,Neutral,Neutral,1.1459812242886975,0.08728693789792605,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.3491,0.0212,-22.2332,-4.00168503980769,0.7981215455602353,Pathogenic,0.9304,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246W,NP_000537:p.Met246Trp,,,,,saturation_mutlist,,,,,,,,4.67721,0.9622157573699951,,0.5536525880952913,,2.6154312940476454,,Uncertain,Neutral,,Uncertain,0.38677698361579765,,0.4785803432076578,11.23148,,1.6213645602933902,,6.426422280146695,,Uncertain,,Destabilizing,,1.3103109360269267,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.4676,0.0212,-22.2332,-6.91837746985783,0.8677817171101401,Pathogenic,0.9977,pathogenic,-4.588,available,https://doi.org/10.1101/2022.10.22.513328 +M246Y,NP_000537:p.Met246Tyr,,,,,saturation_mutlist,,,,,,,,3.7846,0.885390419960022,,0.562808417248699,,2.1737042086243497,,Uncertain,Neutral,,Uncertain,0.35677306281587223,,0.4292977257752689,6.89954,,1.8194850359257142,,4.359512517962857,,Uncertain,,Destabilizing,,1.223960291876146,1.233,1.382,2.48,2.114,,False,1.233,,neutral,neutral,neutral,,False,2.48,,neutral,neutral,neutral,uncertain,,-0.4471,0.0212,-22.2332,-6.91837746985783,0.8706790787559304,Pathogenic,0.998,pathogenic,-4.504,available,https://doi.org/10.1101/2022.10.22.513328 +N247A,NP_000537:p.Asn247Ala,,,,,saturation_mutlist,,,,,,,,0.63382,0.4553529787063599,,0.7090657426646413,,0.6714428713323206,,Neutral,Neutral,,Neutral,0.29575893722324276,,0.2137375510399602,0.33077,,0.18918044294785255,,0.25997522147392627,,Neutral,,Neutral,,0.3337260191517931,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.325,0.0422,-22.2332,-6.36434781999315,0.8092996302264369,Pathogenic,0.9822,pathogenic,-4.236,available,https://doi.org/10.1101/2022.10.22.513328 +N247C,NP_000537:p.Asn247Cys,,,,,saturation_mutlist,,,,,,,,0.45939,0.056571052074432374,,1.1333370180758149,,0.7963635090379074,,Neutral,Neutral,,Neutral,0.13522077555504386,,0.08702918528820291,0.70952,,0.8199663484645155,,0.7647431742322578,,Neutral,,Neutral,,0.17188930560897608,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.3749,0.0422,-22.2332,-6.36434781999315,0.8688034838822214,Pathogenic,0.9642,pathogenic,-4.431,available,https://doi.org/10.1101/2022.10.22.513328 +N247D,NP_000537:p.Asn247Asp,"hg19,17:g.7577542T>C, hg38,17:g.7674224T>C",,,0.940,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.39613,0.6438241755962372,0.8675733333333334,0.6453619736048074,0.6318516666666667,0.5207459868024037,Neutral,Neutral,Neutral,Neutral,Neutral,0.3260681611702763,0.20729607832491403,0.024234050023756525,-0.10663,0.12119999999999997,-0.0025017656384701734,0.007284999999999986,-0.054565882819235086,Neutral,Neutral,Neutral,Neutral,0.41852439458969015,0.27649137609191016,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,uncertain,,-0.3282,0.0422,-22.2332,-4.41228490946553,0.6938272135596166,Pathogenic,0.9854,pathogenic,-4.162,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N247E,NP_000537:p.Asn247Glu,,,,,saturation_mutlist,,,,,,,,0.277,0.6033802819252014,,0.6703000200923444,,0.4736500100461722,,Neutral,Neutral,,Neutral,0.2730398737962317,,0.11429952676661109,0.11248,,0.090332762160939,,0.1014063810804695,,Neutral,,Neutral,,0.3731727360194002,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.3553,0.0422,-22.2332,-4.73180277798174,0.7979720528934758,Pathogenic,0.9975,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328 +N247F,NP_000537:p.Asn247Phe,"hg38,17:g.7674223_7674224inv",,,,"COSMIC,saturation_mutlist",,,,,,,,0.58714,0.46269397258758543,0.22006666666666666,0.056290239420165304,0.4036033333333333,0.32171511971008265,Neutral,Neutral,Neutral,Neutral,Neutral,0.23433427994679992,0.2967476173825533,0.10110126550125367,0.14756,0.8057833333333333,-0.1229958388586357,0.47667166666666666,0.012282080570682148,Neutral,Neutral,Neutral,Neutral,0.3520953821843671,0.3106716953932409,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.3821,0.0422,-22.2332,-7.61411973536705,0.8628638146712628,Pathogenic,0.9967,pathogenic,-4.63,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N247G,NP_000537:p.Asn247Gly,,,,,saturation_mutlist,,,,,,,,-0.21944,0.03567766189575194,,1.1035488735612622,,0.4420544367806311,,Neutral,Neutral,,Neutral,0.3152673134330011,,0.07429420259279926,0.33333,,0.6386448507147829,,0.4859874253573915,,Neutral,,Neutral,,0.13595191818391875,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.3558,0.0422,-22.2332,-5.81347888632858,0.5395502784258973,Uncertain,0.9589,pathogenic,-4.13,available,https://doi.org/10.1101/2022.10.22.513328 +N247H,NP_000537:p.Asn247His,,,,,saturation_mutlist,,,,,,,,0.5984,0.14523854494094848,,0.21777352805190628,,0.4080867640259532,,Neutral,Neutral,,Neutral,0.21177339599014178,,0.08101577609824233,0.61417,,-0.231045696581757,,0.1915621517091215,,Neutral,,Neutral,,0.312900272536025,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.2621,0.0422,-8.9453,-7.34455894760834,0.3711428744214047,Uncertain,0.9627,pathogenic,-3.964,available,https://doi.org/10.1101/2022.10.22.513328 +N247I,NP_000537:p.Asn247Ile,"hg19,17:g.7577540_7577541delinsTA, hg19,17:g.7577541T>A, hg19,17:g.7674223T>A, hg38,17:g.7674222_7674223delinsTA, hg38,17:g.7674223T>A",,,0.953,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",184882,Conflicting classifications of pathogenicity,1,,,,,2.53276,1.0815347051620483,4.04399,0.521789863083395,3.2883750000000003,1.5272749315416976,Uncertain,Uncertain,Uncertain,Destabilizing,Neutral,0.45656648765244257,0.1405888824433378,0.16624672240877894,0.73665,3.5521566666666664,0.19061258233602274,2.144403333333333,0.4636312911680114,Uncertain,Neutral,Uncertain,Neutral,2.2269777873062755,0.518329550408746,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.3753,0.0422,-22.2332,-7.87845834414539,0.8702166051453897,Pathogenic,0.9966,pathogenic,-4.564,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N247K,NP_000537:p.Asn247Lys,"hg38,17:g.7674222G>T",,,0.889,"COSMIC,saturation_mutlist",,,,,,,,0.18571,0.2591312646865845,-0.5730133333333334,0.45103011539185905,-0.1936516666666667,0.3183700576959295,Neutral,Neutral,Neutral,Neutral,Neutral,0.23990034195691787,0.18215656202533276,0.12245986548611998,0.19511,1.1767566666666667,0.04528835077984016,0.6859333333333333,0.12019917538992009,Neutral,Neutral,Neutral,Neutral,0.3605324493332358,0.33621198108561756,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.3282,0.0422,-22.2332,-7.87845834414539,0.8690366775415297,Pathogenic,0.9975,pathogenic,-4.39,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N247L,NP_000537:p.Asn247Leu,,,,,saturation_mutlist,,,,,,,,0.34671,0.5156556987762451,,-0.2520043687008999,,0.04735281564955007,,Neutral,Neutral,,Neutral,0.16840272866960443,,0.09140329670213926,0.19994,,-0.3530940106437887,,-0.07657700532189435,,Neutral,,Neutral,,0.3318674361866473,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.3817,0.0422,-22.2332,-7.87845834414539,0.8596028519049006,Pathogenic,0.9846,pathogenic,-4.511,available,https://doi.org/10.1101/2022.10.22.513328 +N247M,NP_000537:p.Asn247Met,,,,,saturation_mutlist,,,,,,,,0.57606,0.3812637972831726,,0.17599515365736118,,0.3760275768286806,,Neutral,Neutral,,Neutral,0.17270351301779838,,0.15467055369359495,0.27308,,-0.010375380707120537,,0.13135230964643974,,Neutral,,Neutral,,0.314339237463676,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.3358,0.0422,-22.2332,-7.87845834414539,0.8707380504552522,Pathogenic,0.9859,pathogenic,-4.388,available,https://doi.org/10.1101/2022.10.22.513328 +N247P,NP_000537:p.Asn247Pro,,,,,saturation_mutlist,,,,,,,,7.05706,1.5614018106460572,,5.956185237982219,,6.506622618991109,,Destabilizing,Uncertain,,Destabilizing,0.6406985165866476,,0.4352260133136161,0.85123,,3.5694163680250335,,2.2103231840125166,,Uncertain,,Uncertain,,1.374726388241775,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,uncertain,,-0.4906,0.0422,-22.2332,-7.87845834414539,0.8639695214352283,Pathogenic,0.997,pathogenic,-4.594,available,https://doi.org/10.1101/2022.10.22.513328 +N247Q,NP_000537:p.Asn247Gln,,,,,saturation_mutlist,,,,,,,,0.27135,0.29426892280578615,,0.6469845537838861,,0.45916727689194303,,Neutral,Neutral,,Neutral,0.22778908475189155,,0.16492764004134325,0.22346,,0.2814107635372675,,0.2524353817686338,,Neutral,,Neutral,,0.33708243648444436,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.319,0.0422,-22.2332,-4.28863931983678,0.4672364226767995,Uncertain,0.9892,pathogenic,-3.972,available,https://doi.org/10.1101/2022.10.22.513328 +N247R,NP_000537:p.Asn247Arg,,,,,saturation_mutlist,,,,,,,,0.46635,0.3451862382888794,,0.1573260884611059,,0.31183804423055295,,Neutral,Neutral,,Neutral,0.26510700965274,,0.1684452981583833,0.37218,,-0.13112569936795604,,0.12052715031602199,,Neutral,,Neutral,,0.3278396816347023,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.3604,0.0422,-22.2332,-7.87845834414539,0.7739433747485658,Pathogenic,0.9938,pathogenic,-4.376,available,https://doi.org/10.1101/2022.10.22.513328 +N247S,NP_000537:p.Asn247Ser,"hg19,17:g.7577541T>C, hg38,17:g.7674223T>C",,,0.935,"COSMIC,ClinVar,saturation_mutlist",406595,Conflicting classifications of pathogenicity,1,,,,,0.86418,0.5157923126220703,0.8500033333333334,1.0092323240807233,0.8570916666666667,0.9367061620403616,Neutral,Neutral,Neutral,Neutral,Neutral,0.29235731170271506,0.1863971824417478,0.09771183365590881,0.48404,1.5328799999999998,0.23952620532220692,1.00846,0.3617831026611035,Neutral,Neutral,Neutral,Neutral,0.4858151897584102,0.34377586434210783,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.2271,0.0422,-8.9453,-3.85136361305547,0.056724193748996,Benign,0.7867,pathogenic,-3.686,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N247T,NP_000537:p.Asn247Thr,"hg19,17:g.7577541T>G, hg19,17:g.7674223T>G, hg38,17:g.7674223T>G",,,0.950,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.75485,0.9193734860420227,1.5639466666666666,0.9720241671547561,2.1593983333333333,1.863437083577378,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.46632914075913895,0.08161214465724786,0.1737985818491657,0.64518,2.0005666666666664,0.3049011979452275,1.3228733333333331,0.47504059897261375,Uncertain,Neutral,Neutral,Neutral,1.0461681500387763,0.3499233886098926,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,uncertain,,-0.3445,0.0422,-22.2332,-6.36434781999315,0.8707352358193703,Pathogenic,0.9894,pathogenic,-4.31,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N247V,NP_000537:p.Asn247Val,,,,,saturation_mutlist,,,,,,,,2.39178,1.003412721157074,,0.5918418782721673,,1.4918109391360836,,Uncertain,Uncertain,,Neutral,0.4444804328154771,,0.12383917255249953,0.91569,,0.26952826018033305,,0.5926091300901666,,Neutral,,Neutral,,0.4938662460904133,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.3686,0.0422,-22.2332,-7.87845834414539,0.868936198158043,Pathogenic,0.9937,pathogenic,-4.584,available,https://doi.org/10.1101/2022.10.22.513328 +N247W,NP_000537:p.Asn247Trp,,,,,saturation_mutlist,,,,,,,,1.47275,0.755998604297638,,-0.16179673934403963,,0.6554766303279802,,Neutral,Neutral,,Neutral,0.32313824742647607,,0.09629438713415213,0.48234,,-0.4521898308716105,,0.015075084564194735,,Neutral,,Neutral,,0.42931259355250523,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.3872,0.0422,-22.2332,-7.61411973536705,0.8707789323058057,Pathogenic,0.9986,pathogenic,-4.79,available,https://doi.org/10.1101/2022.10.22.513328 +N247Y,NP_000537:p.Asn247Tyr,"hg38,17:g.7674224T>A",,,0.959,"COSMIC,saturation_mutlist",,,,,,,,0.59914,0.5583370590209961,-0.049546666666666676,0.2080740854172108,0.2747966666666667,0.4036070427086054,Neutral,Neutral,Neutral,Neutral,Neutral,0.29339044665808756,0.24992581623798335,0.04903513581520128,0.2469,0.87256,-0.05256235453570903,0.5597300000000001,0.09716882273214549,Neutral,Neutral,Neutral,Neutral,0.32751538722122153,0.3532080458249025,49.466,12.471,79.835,14.963,,False,49.466,,neutral,neutral,neutral,,False,79.835,,neutral,neutral,neutral,neutral,,-0.3657,0.0422,-22.2332,-7.61411973536705,0.867777704798494,Pathogenic,0.9639,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248A,NP_000537:p.Arg248Ala,,,,,saturation_mutlist,,,,,,,,0.70478,0.08700840830802915,,1.0964127575670866,,0.9005963787835433,,Neutral,Neutral,,Neutral,0.07350015312287489,,0.21048644340875117,0.50586,,0.5684208949649658,,0.5371404474824829,,Neutral,,Neutral,,0.15997738098394484,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.4024,0.0804,-22.2302,-7.78923574105153,0.8364974474240843,Pathogenic,0.9999,pathogenic,-4.625,available,https://doi.org/10.1101/2022.10.22.513328 +R248C,NP_000537:p.Arg248Cys,"hg38,17:g.7674219_7674221delinsGCA",,,,"COSMIC,saturation_mutlist",,,,,,,,0.54285,-0.5641321969032288,1.1358266666666668,1.2465706935928234,0.8393383333333334,0.8947103467964117,Neutral,Neutral,Neutral,Neutral,Neutral,0.13189628924964736,0.38983264309472887,0.13861744994721073,0.39513,0.26587333333333335,1.0151150893668872,0.3305016666666667,0.7051225446834436,Neutral,Neutral,Neutral,Neutral,0.3035598083116772,0.195764582705228,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.4113,0.0804,-22.2302,-7.78923574105153,0.8472037373961158,Pathogenic,0.9978,pathogenic,-4.448,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248D,NP_000537:p.Arg248Asp,,,,,saturation_mutlist,,,,,,,,0.40514,0.05612327814102172,,0.7418231769350662,,0.573481588467533,,Neutral,Neutral,,Neutral,0.1437525937642388,,0.27089283562003674,0.15358,,0.13983658769160448,,0.14670829384580225,,Neutral,,Neutral,,0.2190602298529884,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.4935,0.0804,-22.2302,-7.05601679688749,0.8167720682091408,Pathogenic,0.9996,pathogenic,-4.866,available,https://doi.org/10.1101/2022.10.22.513328 +R248E,NP_000537:p.Arg248Glu,,,,,saturation_mutlist,,,,,,,,0.34209,0.043142499923706064,,0.8098082508820929,,0.5759491254410465,,Neutral,Neutral,,Neutral,0.13816821914400626,,0.24117083088252206,0.28729,,0.272994021985777,,0.2801420109928885,,Neutral,,Neutral,,0.23123771945413796,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.4387,0.0804,-22.2302,-7.05601679688749,0.8478851283001736,Pathogenic,0.9988,pathogenic,-4.812,available,https://doi.org/10.1101/2022.10.22.513328 +R248F,NP_000537:p.Arg248Phe,,,,,saturation_mutlist,,,,,,,,0.28208,-0.07116099953651428,,0.15734195729757225,,0.21971097864878614,,Neutral,Neutral,,Neutral,0.16140489950654235,,0.09119347490864253,0.0531,,0.09539504612981237,,0.07424752306490619,,Neutral,,Neutral,,0.1414929795926936,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,neutral,,-0.4346,0.0804,-22.2302,-7.37527863068139,0.7941719867485127,Pathogenic,0.9999,pathogenic,-4.808,available,https://doi.org/10.1101/2022.10.22.513328 +R248G,NP_000537:p.Arg248Gly,"hg19,17:g.7577539G>C, hg19,17:g.7674221G>C, hg38,17:g.7674221G>C",,,0.932,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376652,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,-0.7956,-0.8525285625457764,-0.10374333333333335,1.130007757994086,-0.4496716666666667,0.16720387899704298,Neutral,Neutral,Neutral,Neutral,Neutral,0.2580042722615941,0.4821498562572521,0.2854625615048337,-0.33579,-0.015530000000000007,0.7710090581311717,-0.17565999999999998,0.21760952906558587,Neutral,Neutral,Neutral,Neutral,1.0357310242529187,0.33462224201160806,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.37,0.0804,-8.9424,-7.78923574105153,0.1175684121165306,Benign,0.9985,pathogenic,-4.395,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248H,NP_000537:p.Arg248His,"hg19,17:g.7577537_7577538delinsGT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.52522,-0.31585186123847964,0.35101999999999994,0.2692377333931226,0.43811999999999995,0.3972288666965613,Neutral,Neutral,Neutral,Neutral,Neutral,0.06025421292578045,0.20027456620017098,0.13164124096874807,0.38856,-0.8314033333333333,-0.05399613808591273,-0.22142166666666663,0.16728193095704363,Neutral,Neutral,Neutral,Neutral,0.2355673882824663,0.118856042887832,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.3722,0.0804,-22.2302,-7.37527863068139,0.8180696750264247,Pathogenic,0.996,pathogenic,-4.376,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248I,NP_000537:p.Arg248Ile,,,,,saturation_mutlist,,,,,,,,2.83822,0.8322315907478333,,1.2358200435320812,,2.0370200217660406,,Uncertain,Neutral,,Uncertain,0.10808030629629758,,0.1823521114090478,1.75908,,0.5324232651855568,,1.1457516325927783,,Neutral,,Neutral,,0.21194084053273188,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.4318,0.0804,-22.2302,-7.78923574105153,0.8260364464789325,Pathogenic,0.9999,pathogenic,-4.688,available,https://doi.org/10.1101/2022.10.22.513328 +R248K,NP_000537:p.Arg248Lys,,,,,saturation_mutlist,,,,,,,,-0.03848,-0.07754643678665159,,0.5172068921464951,,0.23936344607324753,,Neutral,Neutral,,Neutral,0.03111434941305939,,0.2922837216284696,0.03852,,0.2332047339637411,,0.13586236698187054,,Neutral,,Neutral,,0.2035709310316203,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.2927,0.0804,-22.2302,-4.31455422016133,0.3809116699357284,Uncertain,0.995,pathogenic,-3.986,available,https://doi.org/10.1101/2022.10.22.513328 +R248L,NP_000537:p.Arg248Leu,"hg19,17:g.7577537_7577538delinsAA, hg19,17:g.7577538C>A, hg19,17:g.7577538_7577539delinsAA, hg19,17:g.7674220C>A, hg38,17:g.7674219_7674220delinsAA, hg38,17:g.7674220C>A",,,0.960,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",230253,Pathogenic,3,Oncogenic,1,,,0.15731,0.07516001939773559,0.34025,0.16695191720064426,0.24878,0.16213095860032212,Neutral,Neutral,Neutral,Neutral,Neutral,0.10190192974321417,0.5503081522807622,0.0863057507516077,0.3568,-0.19931999999999997,-0.13799743958522825,0.07874000000000002,0.10940128020738588,Neutral,Neutral,Neutral,Neutral,0.44037767177730525,0.14735371004131423,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.4049,0.0804,-22.2302,-7.78923574105153,0.8641967556697767,Pathogenic,0.999,pathogenic,-4.496,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248M,NP_000537:p.Arg248Met,,,,,saturation_mutlist,,,,,,,,0.37058,-0.08599426627159117,,0.48260723237010666,,0.4265936161850533,,Neutral,Neutral,,Neutral,0.05687617098527051,,0.09019698162232204,0.5749,,0.22033408936400875,,0.3976170446820044,,Neutral,,Neutral,,0.14915741525183793,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.3707,0.0804,-22.2302,-7.78923574105153,0.8510988626688266,Pathogenic,1.0,pathogenic,-4.688,available,https://doi.org/10.1101/2022.10.22.513328 +R248N,NP_000537:p.Arg248Asn,,,,,saturation_mutlist,,,,,,,,0.10465,-0.41765025615692136,,0.39948729271368805,,0.252068646356844,,Neutral,Neutral,,Neutral,0.11380981320788977,,0.18056506587231527,0.17078,,0.1296138919928508,,0.1501969459964254,,Neutral,,Neutral,,0.24462472266822433,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.4173,0.0804,-22.2302,-7.05601679688749,0.8349916134350399,Pathogenic,0.9997,pathogenic,-4.684,available,https://doi.org/10.1101/2022.10.22.513328 +R248P,NP_000537:p.Arg248Pro,"hg19,17:g.7577537_7577538delinsAG, hg19,17:g.7577538C>G, hg19,17:g.7674220C>G, hg38,17:g.7674220C>G",,,0.965,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",237954,Pathogenic/Likely pathogenic,2,,,,,4.44504,1.192392430305481,6.3229033333333335,5.39364102387783,5.383971666666667,4.919340511938914,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.14436280693619502,0.682419682665212,0.18351135079090902,3.43156,6.37415,2.314938924167253,4.902855000000001,2.873249462083627,Destabilizing,Uncertain,Destabilizing,Uncertain,0.5962688733001804,0.5415399256423581,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.4716,0.0804,-7.9424,-4.8646206736246,0.6995874531231092,Pathogenic,0.9994,pathogenic,-4.511,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248Q,NP_000537:p.Arg248Gln,"hg19,17:g.7577537_7577538delinsTT, hg19,17:g.7577538C>T, hg19,17:g.7674219_7674220delinsTT, hg19,17:g.7674220C>T, hg38,17:g.7674219_7674220delinsTT, hg38,17:g.7674220C>T",,1.19296627087e-05,0.934,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12356,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,0.17983,-0.11568073868751524,0.14161,0.7625875513550108,0.16072,0.4712087756775054,Neutral,Neutral,Neutral,Neutral,Neutral,0.05374101218136776,0.08154886020049576,0.19719526456224737,0.2356,0.08673333333333333,0.43010638037569654,0.16116666666666668,0.33285319018784826,Neutral,Neutral,Neutral,Neutral,0.19135261348852514,0.23545546346348242,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,destabilizing,-0.3093,0.0804,-8.9424,-2.41390063355383,0.0051465720633868,Benign,0.9963,pathogenic,-3.865,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248S,NP_000537:p.Arg248Ser,,,,,saturation_mutlist,,,,,,,,0.34671,0.14199756860733032,,1.053298243806857,,0.7000041219034285,,Neutral,Neutral,,Neutral,0.11439247272366872,,0.2720952730306596,0.40641,,0.5147987401505963,,0.4606043700752982,,Neutral,,Neutral,,0.19113351030283096,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.403,0.0804,-22.2302,-7.78923574105153,0.8318611716201587,Pathogenic,0.9998,pathogenic,-4.566,available,https://doi.org/10.1101/2022.10.22.513328 +R248T,NP_000537:p.Arg248Thr,,,,,saturation_mutlist,,,,,,,,2.52864,0.57275031208992,,1.2263818855153457,,1.8775109427576728,,Uncertain,Neutral,,Neutral,0.14047885762759674,,0.05504633847707757,1.19334,,0.5998254966210866,,0.8965827483105433,,Neutral,,Neutral,,0.07039305866942465,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.4073,0.0804,-22.2302,-7.78923574105153,0.8519966515306652,Pathogenic,0.9999,pathogenic,-4.676,available,https://doi.org/10.1101/2022.10.22.513328 +R248V,NP_000537:p.Arg248Val,,,,,saturation_mutlist,,,,,,,,2.72978,0.8020346999168396,,1.121623939027329,,1.9257019695136646,,Uncertain,Neutral,,Neutral,0.09467011747370929,,0.10724539540367173,1.50663,,0.5583378810843546,,1.0324839405421773,,Neutral,,Neutral,,0.12519020320600524,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,uncertain,,-0.4189,0.0804,-22.2302,-7.78923574105153,0.7953089369008473,Pathogenic,0.9999,pathogenic,-4.752,available,https://doi.org/10.1101/2022.10.22.513328 +R248W,NP_000537:p.Arg248Trp,"hg19,17:g.7577539G>A, hg19,17:g.7577539_7577540delinsAA, hg19,17:g.7674221G>A, hg19,17:g.7674221_7674222delinsAA, hg38,17:g.7674221G>A, hg38,17:g.7674221_7674222delinsAA",,3.9765226105e-06,0.927,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","437017, 12347","Likely pathogenic, Pathogenic","1, 3",Oncogenic,1,Tier I - Strong,1,0.92523,0.10699267387390135,0.6547633333333334,0.09680036298232535,0.7899966666666667,0.5110151814911627,Neutral,Neutral,Neutral,Neutral,Neutral,0.1483381322805495,0.5881117404787026,0.16113322952440243,0.61262,-0.1869633333333333,-0.18397675051809725,0.2128283333333334,0.2143216247409514,Neutral,Neutral,Neutral,Neutral,1.2909329116917303,0.17526741748834773,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,neutral,neutral,-0.4202,0.0804,-22.2302,-2.72930677208217,0.816271765854447,Pathogenic,0.9968,pathogenic,-4.533,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248Y,NP_000537:p.Arg248Tyr,,,,,"COSMIC,saturation_mutlist",,,,,,,,0.406,-0.018365381956100487,0.5280066666666666,0.2698704006375748,0.4670033333333333,0.33793520031878743,Neutral,Neutral,Neutral,Neutral,Neutral,0.14096897898847466,0.34693984630704433,0.09102285976588853,0.28575,-0.5784566666666666,0.1317486036532953,-0.1463533333333333,0.20874930182664764,Neutral,Neutral,Neutral,Neutral,0.7619999808544763,0.12547852344317856,76.731,10.523,83.81,10.9,,True,76.731,,neutral,neutral,neutral,,True,83.81,,neutral,neutral,neutral,neutral,,-0.4239,0.0804,-22.2302,-7.37527863068139,0.7531925884834364,Pathogenic,0.9993,pathogenic,-4.521,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249A,NP_000537:p.Arg249Ala,,,,,saturation_mutlist,,,,,,,,1.56479,0.7101252555847168,,1.4241000030313196,,1.4944450015156598,,Neutral,Neutral,,Neutral,0.37165677817837195,,0.39872836913583076,-1.23411,,1.542608779299713,,0.15424938964985646,,Neutral,,Neutral,,0.21350553138968684,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.4024,0.0804,-22.2302,-5.60825935947658,0.7817496799181076,Pathogenic,0.9991,pathogenic,-4.642,available,https://doi.org/10.1101/2022.10.22.513328 +R249C,NP_000537:p.Arg249Cys,,,,,saturation_mutlist,,,,,,,,1.20992,0.23580750703811645,,1.8245416702195019,,1.517230835109751,,Neutral,Neutral,,Neutral,0.21235827593033513,,0.40305345667605674,-1.00005,,2.131471249173563,,0.5657106245867815,,Uncertain,,Neutral,,0.44894920105371355,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.4113,0.0804,-22.2302,-6.93003648537252,0.841513490531449,Pathogenic,0.9866,pathogenic,-4.4,available,https://doi.org/10.1101/2022.10.22.513328 +R249D,NP_000537:p.Arg249Asp,,,,,saturation_mutlist,,,,,,,,2.15375,1.2730860328674316,,2.13173645838612,,2.14274322919306,,Uncertain,Uncertain,,Uncertain,0.5161537125948052,,0.6151870808428628,-0.1047,,2.595851360750622,,1.245575680375311,,Uncertain,,Neutral,,0.5222507744732416,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.4935,0.0804,-22.2302,-7.34865171184662,0.8659884233402495,Pathogenic,0.9995,pathogenic,-4.814,available,https://doi.org/10.1101/2022.10.22.513328 +R249E,NP_000537:p.Arg249Glu,,,,,saturation_mutlist,,,,,,,,2.01819,0.7862871956825256,,1.6285097903552568,,1.8233498951776284,,Uncertain,Neutral,,Neutral,0.637490580821995,,0.6311617316928895,-0.04047,,2.26309106906394,,1.11131053453197,,Uncertain,,Neutral,,0.6110209146052007,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.3709,0.0804,-8.9424,-4.73127044247835,0.260375439748877,Benign,0.9969,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +R249F,NP_000537:p.Arg249Phe,,,,,saturation_mutlist,,,,,,,,0.77135,0.4454381990432739,,0.23192711740929706,,0.5016385587046486,,Neutral,Neutral,,Neutral,0.20656093404755496,,0.3980819396761786,-0.95298,,0.6613143680802542,,-0.1458328159598729,,Neutral,,Neutral,,1.0324009364343942,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.4346,0.0804,-22.2302,-7.87688531520774,0.8468662335493051,Pathogenic,0.9993,pathogenic,-4.778,available,https://doi.org/10.1101/2022.10.22.513328 +R249G,NP_000537:p.Arg249Gly,"hg19,17:g.7577534_7577536delinsACC, hg19,17:g.7577536T>C, hg19,17:g.7674218T>C, hg38,17:g.7674216_7674218delinsACC, hg38,17:g.7674218T>C",,,0.888,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376654,Conflicting classifications of pathogenicity,1,,,,,2.71902,1.0665143704414368,2.87857,2.4967759943460837,2.798795,2.607897997173042,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.399130558517066,0.1990001453935818,0.48329110035173956,-1.27928,3.43345,2.638996512038567,1.077085,0.6798582560192836,Uncertain,Uncertain,Neutral,Neutral,1.4505566760615274,0.213394331883747,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.4378,0.0804,-22.2302,-7.87688531520774,0.8326299114228841,Pathogenic,0.9979,pathogenic,-4.386,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249H,NP_000537:p.Arg249His,,,,,saturation_mutlist,,,,,,,,1.78378,0.3294758129119873,,0.8638685023037255,,1.3238242511518628,,Neutral,Neutral,,Neutral,0.32374364441290543,,0.49582516130889215,0.31362,,1.1434303090477511,,0.7285251545238756,,Neutral,,Neutral,,0.5215479029477196,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.3722,0.0804,-22.2302,-7.87688531520774,0.868839910325411,Pathogenic,0.9648,pathogenic,-4.378,available,https://doi.org/10.1101/2022.10.22.513328 +R249I,NP_000537:p.Arg249Ile,"hg19,17:g.7577534_7577535delinsAA, hg38,17:g.7674216_7674217delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.45566,0.530064001083374,0.5218833333333334,0.6414214130521768,0.4887716666666667,0.5485407065260884,Neutral,Neutral,Neutral,Neutral,Neutral,0.531609004544709,1.7321963458825587,0.3431131374749963,0.95575,-0.44149666666666665,1.4233523093306104,0.25712666666666667,1.1895511546653053,Neutral,Neutral,Neutral,Neutral,0.8015160581603396,1.197929970278203,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.4318,0.0804,-22.2302,-7.87688531520774,0.8602560283999294,Pathogenic,0.9981,pathogenic,-4.67,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249K,NP_000537:p.Arg249Lys,"hg19,17:g.7577535C>T, hg19,17:g.7674217C>T, hg38,17:g.7674217C>T",,,0.893,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142241,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,1.17561,0.17418683767318727,1.2992033333333335,1.2282598571829064,1.2374066666666668,1.2019349285914531,Neutral,Neutral,Neutral,Neutral,Neutral,0.08822315165560321,0.2578632043459392,0.4654078124371185,-0.53425,1.00941,1.6646793005450065,0.23757999999999996,0.5652146502725033,Neutral,Neutral,Neutral,Neutral,0.4641188916646251,0.3872849278581851,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,uncertain,,-0.2927,0.0804,-22.2302,-2.22538311817255,0.0805817081852227,Benign,0.9066,pathogenic,-3.778,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249L,NP_000537:p.Arg249Leu,,,,,saturation_mutlist,,,,,,,,0.00318,0.20021021127700805,,0.15239526854906024,,0.07778763427453012,,Neutral,Neutral,,Neutral,0.2799629776831669,,0.23022295976206772,-1.02828,,0.47557130247789386,,-0.27635434876105314,,Neutral,,Neutral,,0.7684758494532343,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.4049,0.0804,-22.2302,-7.87688531520774,0.8633589060423119,Pathogenic,0.9922,pathogenic,-4.493,available,https://doi.org/10.1101/2022.10.22.513328 +R249M,NP_000537:p.Arg249Met,"hg19,17:g.7577535C>A, hg19,17:g.7674217C>A, hg38,17:g.7674217C>A",,,0.911,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376653,Conflicting classifications of pathogenicity,1,Oncogenic,1,Tier I - Strong,1,0.11107,0.27908868312835694,0.7736966666666666,0.635557992303018,0.4423833333333333,0.373313996151509,Neutral,Neutral,Neutral,Neutral,Neutral,0.22895308249477955,0.196008210088818,0.3471049484085975,-1.37924,-0.2716566666666666,0.7306056351720499,-0.8254483333333333,-0.32431718241397506,Neutral,Neutral,Neutral,Neutral,0.8629381731554636,0.6731084874623936,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.3707,0.0804,-22.2302,-7.87688531520774,0.6325337450572295,Uncertain,0.9991,pathogenic,-4.395,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249N,NP_000537:p.Arg249Asn,,,,,saturation_mutlist,,,,,,,,1.42313,0.626127324104309,,1.2442950320245247,,1.3337125160122625,,Neutral,Neutral,,Neutral,0.3316712141157666,,0.40373256894806414,-0.28127,,1.61076508388343,,0.664747541941715,,Neutral,,Neutral,,0.36657387756752724,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.4173,0.0804,-22.2302,-7.34865171184662,0.7433369253541168,Pathogenic,0.9988,pathogenic,-4.51,available,https://doi.org/10.1101/2022.10.22.513328 +R249P,NP_000537:p.Arg249Pro,,,,,saturation_mutlist,,,,,,,,5.76253,1.5055723762512208,,5.763813900259021,,5.763171950129511,,Destabilizing,Uncertain,,Destabilizing,0.3022762411930444,,0.45013021808633585,3.15285,,6.581387111886987,,4.8671185559434935,,Destabilizing,,Destabilizing,,1.4139623172487474,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.5445,0.0804,-22.2302,-7.87688531520774,0.8243009654134557,Pathogenic,0.999,pathogenic,-4.678,available,https://doi.org/10.1101/2022.10.22.513328 +R249Q,NP_000537:p.Arg249Gln,,,,,saturation_mutlist,,,,,,,,1.57253,0.3914773726463318,,1.246528694943394,,1.409529347471697,,Neutral,Neutral,,Neutral,0.4415525182940217,,0.4780879317078023,-0.53571,,1.6003981071432538,,0.5323440535716268,,Neutral,,Neutral,,0.59288703844695,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.3771,0.0804,-22.2302,-7.1933300927982,0.2796066225798573,Benign,0.9675,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328 +R249S,NP_000537:p.Arg249Ser,"hg19,17:g.7577534C>A, hg19,17:g.7577534C>G, hg19,17:g.7674216C>A, hg19,17:g.7674216C>G, hg38,17:g.7674216C>A, hg38,17:g.7674216C>G",,,0.769,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","406598, 12352","Conflicting classifications of pathogenicity, Pathogenic/Likely pathogenic","1, 2",Oncogenic,1,,,1.74379,0.7962528729438781,1.9210866666666666,1.971830818676138,1.8324383333333332,1.857810409338069,Neutral,Neutral,Neutral,Neutral,Neutral,0.31078599272312774,0.5038972730185742,0.45373356088002553,-0.57313,1.6125833333333333,2.167379981251012,0.5197266666666667,0.797124990625506,Neutral,Uncertain,Neutral,Neutral,0.5935824996484388,0.2521966406178398,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.3301,0.0804,-7.9424,-3.73633473777127,0.5292616088672764,Uncertain,0.9995,pathogenic,-4.344,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249T,NP_000537:p.Arg249Thr,"hg19,17:g.7577535C>G, hg19,17:g.7674217C>G, hg38,17:g.7674217C>G",,,0.921,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376015,Pathogenic/Likely pathogenic,2,,,,,1.42723,0.7453671503067016,1.5480733333333336,1.4956200258369703,1.4876516666666668,1.4614250129184851,Neutral,Neutral,Neutral,Neutral,Neutral,0.3723434462272963,0.7445391637934315,0.496816283604422,1.09919,1.0541966666666667,1.954902545036898,1.0766933333333333,1.527046272518449,Neutral,Neutral,Neutral,Neutral,0.8876277261079419,0.5389727390076438,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.4073,0.0804,-22.2302,-6.93003648537252,0.8513918186508777,Pathogenic,0.9994,pathogenic,-4.546,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249V,NP_000537:p.Arg249Val,"hg38,17:g.7674217_7674218delinsAC",,,,"COSMIC,saturation_mutlist",,,,,,,,0.9204,0.5677442622184753,1.0511333333333333,0.8407465776694999,0.9857666666666667,0.88057328883475,Neutral,Neutral,Neutral,Neutral,Neutral,0.4661787413126655,1.4894193249123036,0.3295871293599084,0.42183,-0.20193000000000003,1.542792600055152,0.10994999999999998,0.9823113000275759,Neutral,Neutral,Neutral,Neutral,0.5472684224400308,0.9429377173685506,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.4189,0.0804,-22.2302,-7.87688531520774,0.8545689448061059,Pathogenic,0.9984,pathogenic,-4.643,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249W,NP_000537:p.Arg249Trp,"hg19,17:g.7577536T>A, hg19,17:g.7674218T>A, hg38,17:g.7674218T>A",,,0.846,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141881,Conflicting classifications of pathogenicity,1,,,,,1.1487,0.3644304692745209,1.1752833333333332,0.08169266369222224,1.1619916666666668,0.6151963318461111,Neutral,Neutral,Neutral,Neutral,Neutral,0.25422616591176095,1.0125267556080788,0.503048924469729,0.32906,-0.4439933333333334,0.5507259311962088,-0.057466666666666694,0.4398929655981044,Neutral,Neutral,Neutral,Neutral,0.46258462550711255,1.0456838544112077,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.3523,0.0804,-8.9424,-7.87688531520774,0.8350813245641621,Pathogenic,0.9904,pathogenic,-4.469,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249Y,NP_000537:p.Arg249Tyr,,,,,saturation_mutlist,,,,,,,,1.04926,0.2981316065788269,,0.394532834595058,,0.7218964172975291,,Neutral,Neutral,,Neutral,0.24338172075651965,,0.42471686468925884,-0.67239,,0.9185395393529081,,0.12307476967645403,,Neutral,,Neutral,,0.9674061485365049,14.239,4.079,33.515,16.948,P,True,14.239,,uncertain,neutral,neutral,P,True,33.515,,damaging,neutral,neutral,damaging,,-0.4239,0.0804,-22.2302,-7.87688531520774,0.8394722016292288,Pathogenic,0.9966,pathogenic,-4.658,available,https://doi.org/10.1101/2022.10.22.513328 +P250A,NP_000537:p.Pro250Ala,"hg19,17:g.7577533G>C, hg38,17:g.7674215G>C",,,0.892,"COSMIC,ClinVar,saturation_mutlist",1759142,Uncertain significance,2,,,,,1.21775,-0.1158735167980194,0.6487533333333334,-0.08141610377566406,0.9332516666666668,0.5681669481121681,Neutral,Neutral,Neutral,Neutral,Neutral,0.13430958411319144,0.30482555998836813,0.09764271714913779,1.20846,0.8897966666666667,0.07177650751522856,1.0491283333333334,0.6401182537576143,Neutral,Neutral,Neutral,Neutral,0.5078545064834569,0.03286500860249977,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,uncertain,,-0.243,0.0957,-7.3604,-4.08421037088883,0.0001692279423573,Benign,0.4876,ambiguous,-3.43,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250C,NP_000537:p.Pro250Cys,,,,,saturation_mutlist,,,,,,,,1.70242,-0.0780704116821289,,0.4677584539880748,,1.0850892269940373,,Neutral,Neutral,,Neutral,0.27346781670065146,,0.07336544831037271,1.96105,,0.5340426749951709,,1.2475463374975855,,Neutral,,Neutral,,0.07551260716798704,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,uncertain,,-0.3515,0.0957,-22.2332,-6.36482132236824,0.5202731322287036,Uncertain,0.98,pathogenic,-4.39,available,https://doi.org/10.1101/2022.10.22.513328 +P250D,NP_000537:p.Pro250Asp,,,,,saturation_mutlist,,,,,,,,2.495,-0.015627942085266112,,0.85952025188907,,1.677260125944535,,Uncertain,Neutral,,Neutral,0.3831258270331474,,0.5196565661334575,3.00243,,0.28727839570076275,,1.6448541978503814,,Uncertain,,Neutral,,0.08141124322042159,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,uncertain,,-0.3774,0.0957,-22.2332,-6.79863953820232,0.7730113123811679,Pathogenic,0.9909,pathogenic,-4.449,available,https://doi.org/10.1101/2022.10.22.513328 +P250E,NP_000537:p.Pro250Glu,,,,,saturation_mutlist,,,,,,,,1.50343,0.2695175671577454,,0.698537728382488,,1.100983864191244,,Neutral,Neutral,,Neutral,0.35796362909361207,,0.37507897389897693,2.02832,,0.16441588370356636,,1.096367941851783,,Uncertain,,Neutral,,0.10443997750839398,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,neutral,,-0.3612,0.0957,-22.2332,-6.79863953820232,0.5805033766108295,Uncertain,0.9802,pathogenic,-4.222,available,https://doi.org/10.1101/2022.10.22.513328 +P250F,NP_000537:p.Pro250Phe,"hg19,17:g.7577532_7577533delinsAA, hg19,17:g.7674214_7674215delinsAA, hg38,17:g.7674214_7674215delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.91787,0.3054197263717651,0.5106566666666666,-0.2996181578599468,1.2142633333333333,0.8091259210700266,Neutral,Neutral,Neutral,Neutral,Neutral,0.44071404954379106,0.1253901177215422,0.13117584720484998,2.13736,0.5655333333333333,-0.38073583615665535,1.3514466666666667,0.8783120819216724,Uncertain,Uncertain,Neutral,Neutral,0.44046738966188587,0.21832605795729682,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,neutral,,-0.38,0.0957,-22.2332,-7.87956709322664,0.841164041561647,Pathogenic,0.9966,pathogenic,-4.636,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250G,NP_000537:p.Pro250Gly,,,,,saturation_mutlist,,,,,,,,2.05035,0.44155286490917206,,1.3733623870488323,,1.711856193524416,,Uncertain,Neutral,,Neutral,0.20164874146186965,,0.1943260328402745,1.73506,,1.002153220494795,,1.3686066102473975,,Neutral,,Neutral,,0.049895913056923494,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,uncertain,,-0.3332,0.0957,-22.2332,-6.52729321979455,0.448919611356421,Uncertain,0.8979,pathogenic,-4.174,available,https://doi.org/10.1101/2022.10.22.513328 +P250H,NP_000537:p.Pro250His,"hg19,17:g.7577532G>T, hg38,17:g.7674214G>T",,,0.941,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.91137,0.46438929438591003,1.2043066666666666,-0.07909996722162803,2.057838333333333,1.416135016389186,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.37684395510779006,0.22290918813623534,0.27449638132023413,3.04344,1.3032899999999998,-0.30502924594343656,2.173365,1.3692053770282817,Uncertain,Uncertain,Uncertain,Neutral,0.31456199177056765,0.15999537069876282,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,neutral,,-0.3576,0.0957,-22.2332,-7.87956709322664,0.8366416558029965,Pathogenic,0.9681,pathogenic,-4.323,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250I,NP_000537:p.Pro250Ile,,,,,saturation_mutlist,,,,,,,,1.61546,0.37154930233955386,,-0.4300017750914947,,0.5927291124542526,,Neutral,Neutral,,Neutral,0.4486144753476201,,0.2125416672881321,2.61688,,-0.49545493206838725,,1.0607125339658063,,Uncertain,,Neutral,,0.20684073212227494,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,neutral,,-0.363,0.0957,-22.2332,-7.26553434087479,0.8657678820995451,Pathogenic,0.9914,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +P250K,NP_000537:p.Pro250Lys,,,,,saturation_mutlist,,,,,,,,1.9461,1.009877016544342,,1.1113990605922908,,1.5287495302961454,,Neutral,Uncertain,,Neutral,0.33859090298600314,,0.6459709243925561,1.86202,,0.03854817579786303,,0.9502840878989315,,Neutral,,Neutral,,0.10564889152461243,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,neutral,,-0.3529,0.0957,-22.2332,-6.06238074383924,0.6300274080261309,Uncertain,0.9833,pathogenic,-4.375,available,https://doi.org/10.1101/2022.10.22.513328 +P250L,NP_000537:p.Pro250Leu,"hg19,17:g.7577531_7577532delinsAA, hg19,17:g.7577532G>A, hg19,17:g.7674214G>A, hg38,17:g.7674213_7674214delinsAA, hg38,17:g.7674213_7674214delinsCA, hg38,17:g.7674214G>A",,,0.962,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",420136,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,1.51205,0.6180272090435028,0.6075933333333333,-0.32762693912956115,1.0598216666666667,0.5922115304352193,Neutral,Neutral,Neutral,Neutral,Neutral,0.3699652980128906,0.14573484811655568,0.3609318339624722,1.74378,0.08401333333333334,-0.6031361172294386,0.9138966666666667,0.5703219413852807,Neutral,Neutral,Neutral,Neutral,0.6575988324367845,0.15016442003377714,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,neutral,,-0.2998,0.0957,-8.9453,-6.44255387688277,0.0529280836348316,Benign,0.9135,pathogenic,-3.873,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250M,NP_000537:p.Pro250Met,,,,,saturation_mutlist,,,,,,,,1.33107,0.5797922283411026,,-0.11677096708848587,,0.6071495164557571,,Neutral,Neutral,,Neutral,0.31484793016905094,,0.2671768894081389,1.62943,,-0.26526618015131426,,0.6820819099243428,,Neutral,,Neutral,,0.20056177152714882,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,neutral,,-0.3185,0.0957,-22.2332,-7.26553434087479,0.8161179912941776,Pathogenic,0.9774,pathogenic,-4.434,available,https://doi.org/10.1101/2022.10.22.513328 +P250N,NP_000537:p.Pro250Asn,"hg38,17:g.7674214_7674215delinsTT",,,,"COSMIC,saturation_mutlist",,,,,,,,2.36481,0.5065290606021882,1.1675733333333331,0.3351994312538144,1.7661916666666664,1.350004715626907,Uncertain,Uncertain,Neutral,Neutral,Neutral,0.3238047549686594,0.12902071160175108,0.1459507804036765,2.08421,1.1441033333333335,-0.11608175294252154,1.6141566666666667,0.9840641235287393,Uncertain,Uncertain,Neutral,Neutral,0.44631180060083064,0.06137941181442244,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,uncertain,,-0.3456,0.0957,-22.2332,-6.79863953820232,0.8187479292165503,Pathogenic,0.9671,pathogenic,-4.218,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250Q,NP_000537:p.Pro250Gln,"hg38,17:g.7674213_7674214delinsCT",,,,"COSMIC,saturation_mutlist",,,,,,,,1.53812,0.6227779763936997,0.8291366666666667,0.42257791240754,1.1836283333333333,0.9803489562037699,Neutral,Neutral,Neutral,Neutral,Neutral,0.3318988137461909,0.2577945228708753,0.21304319058764176,2.08361,1.1453499999999999,0.0954609647202936,1.61448,1.0895354823601469,Uncertain,Uncertain,Neutral,Neutral,0.5040027893441331,0.08911809712475625,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,neutral,,-0.2795,0.0957,-8.9453,-4.85161353414926,0.2449128027232194,Benign,0.8981,pathogenic,-3.936,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250R,NP_000537:p.Pro250Arg,"hg19,17:g.7577532G>C, hg38,17:g.7674214G>C",,,0.963,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.39005,1.0146767127513885,2.1589566666666666,0.47781846661074584,2.2745033333333335,1.4339342333053728,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.3421382146311945,0.25348016284426583,0.5511117749337893,2.00532,1.66678,-0.36388260647642756,1.8360500000000002,0.8207186967617863,Uncertain,Uncertain,Neutral,Neutral,0.24047428511173496,0.15061763204230438,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,neutral,,-0.3887,0.0957,-22.2332,-6.63589747066615,0.2299835056498123,Benign,0.9472,pathogenic,-4.174,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250S,NP_000537:p.Pro250Ser,"hg19,17:g.7577533G>A, hg38,17:g.7674215G>A",,,0.939,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1316970,Uncertain significance,2,,,,,1.50582,-0.13335949778556822,0.6219966666666666,0.43501316382385685,1.0639083333333332,0.9704165819119284,Neutral,Neutral,Neutral,Neutral,Neutral,0.1835227494254779,0.18171675859852765,0.053580425200092756,1.59879,1.3963733333333332,0.24186718520861328,1.4975816666666666,0.9203285926043066,Neutral,Neutral,Neutral,Neutral,0.4881126755393904,0.08181232980751373,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,uncertain,,-0.3185,0.0957,-22.2332,-5.55888467040599,0.3955166968068279,Uncertain,0.8246,pathogenic,-3.74,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250T,NP_000537:p.Pro250Thr,"hg19,17:g.7577533G>T, hg38,17:g.7674215G>T",,,0.949,"COSMIC,ClinVar,saturation_mutlist",1759140,Uncertain significance,2,,,,,1.52948,0.07266961693763734,0.015080000000000001,0.04928541204377598,0.77228,0.789382706021888,Neutral,Neutral,Neutral,Neutral,Neutral,0.3206196295499976,0.08381648167275932,0.0837948488213353,2.71049,0.6298166666666666,-0.03957715734429653,1.6701533333333334,1.3354564213278517,Uncertain,Uncertain,Neutral,Neutral,0.7378591252325127,0.03394933609386755,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,uncertain,,-0.3307,0.0957,-22.2332,-6.36482132236824,0.5957661207463998,Uncertain,0.9194,pathogenic,-4.046,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250V,NP_000537:p.Pro250Val,,,,,saturation_mutlist,,,,,,,,1.47155,0.22965657353401184,,-0.47807776649994443,,0.4967361167500277,,Neutral,Neutral,,Neutral,0.47689614611130066,,0.11861109654589382,2.55659,,-0.5421588021564919,,1.007215598921754,,Uncertain,,Neutral,,0.15610874113659548,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,neutral,,-0.3184,0.0957,-22.2332,-7.26553434087479,0.8100130486626577,Pathogenic,0.9694,pathogenic,-4.339,available,https://doi.org/10.1101/2022.10.22.513328 +P250W,NP_000537:p.Pro250Trp,,,,,saturation_mutlist,,,,,,,,3.09089,-0.2343447208404541,,-0.3406785812929443,,1.3751057093535277,,Uncertain,Neutral,,Neutral,0.4774064510853805,,0.3736273979481769,3.13787,,-0.6616308409807542,,1.238119579509623,,Uncertain,,Neutral,,0.16424768149489066,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,neutral,,-0.3925,0.0957,-22.2332,-7.87956709322664,0.8310535278588256,Pathogenic,0.9979,pathogenic,-4.71,available,https://doi.org/10.1101/2022.10.22.513328 +P250Y,NP_000537:p.Pro250Tyr,,,,,saturation_mutlist,,,,,,,,1.82631,0.1231987190246582,,-0.11136730208744634,,0.8574713489562769,,Neutral,Neutral,,Neutral,0.5163021761773694,,0.24987131582489489,2.34843,,-0.2927539663379021,,1.027838016831049,,Uncertain,,Neutral,,0.2087791986089242,24.23,7.699,19.675,8.483,,True,24.23,,neutral,neutral,neutral,,True,19.675,,neutral,neutral,neutral,neutral,,-0.3809,0.0957,-22.2332,-7.87956709322664,0.8525930830501938,Pathogenic,0.9949,pathogenic,-4.608,available,https://doi.org/10.1101/2022.10.22.513328 +I251A,NP_000537:p.Ile251Ala,,,,,saturation_mutlist,,,,,,,,4.1214,2.249734869003296,,3.3204552422569953,,3.7209276211284976,,Destabilizing,Destabilizing,,Destabilizing,0.32488183102094426,,0.288332555017533,0.78622,,2.878698722479506,,1.832459361239753,,Uncertain,,Neutral,,0.14274273754352618,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.4208,0.0592,-22.2332,-5.12691728192533,0.8594171368121056,Pathogenic,0.9894,pathogenic,-4.349,available,https://doi.org/10.1101/2022.10.22.513328 +I251C,NP_000537:p.Ile251Cys,,,,,saturation_mutlist,,,,,,,,3.41144,1.321171154975891,,3.143193640735221,,3.27731682036761,,Destabilizing,Uncertain,,Destabilizing,0.3441186353887922,,0.3700392634112779,0.37176,,2.7492691406241665,,1.5605145703120833,,Uncertain,,Neutral,,0.09753270613845536,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.4008,0.0592,-22.2332,-6.17822887715965,0.8702660809084544,Pathogenic,0.9972,pathogenic,-4.589,available,https://doi.org/10.1101/2022.10.22.513328 +I251D,NP_000537:p.Ile251Asp,,,,,saturation_mutlist,,,,,,,,5.22088,3.2626826667785647,,4.448052880833247,,4.834466440416623,,Destabilizing,Destabilizing,,Destabilizing,0.5546762473827304,,0.29938758784903885,3.30488,,3.990980172196293,,3.6479300860981465,,Destabilizing,,Destabilizing,,0.14690107589840354,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.5449,0.0592,-22.2332,-7.82977005918113,0.8585892337927903,Pathogenic,0.9998,pathogenic,-4.912,available,https://doi.org/10.1101/2022.10.22.513328 +I251E,NP_000537:p.Ile251Glu,,,,,saturation_mutlist,,,,,,,,4.28232,3.1122690200805665,,4.1373147945285105,,4.209817397264255,,Destabilizing,Destabilizing,,Destabilizing,0.5563665349498977,,0.2698255176080955,1.56475,,3.558927929587901,,2.5618389647939503,,Uncertain,,Uncertain,,0.1017434240380959,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.5258,0.0592,-22.2332,-7.82977005918113,0.870679803342197,Pathogenic,0.9995,pathogenic,-4.78,available,https://doi.org/10.1101/2022.10.22.513328 +I251F,NP_000537:p.Ile251Phe,"hg19,17:g.7577530T>A, hg19,17:g.7674212T>A, hg38,17:g.7674212T>A",,,0.962,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1518844,Likely pathogenic,1,,,Tier I - Strong,1,6.67246,1.2663532018661499,1.743763333333333,1.6143383254143586,4.2081116666666665,4.14339916270718,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.44501548138612984,1.864628503917663,0.2513211504466148,5.95194,2.7128099999999997,1.7062379477964014,4.332375,3.8290889738982004,Uncertain,Uncertain,Destabilizing,Destabilizing,2.3681085962007735,0.15808360138951028,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,neutral,,-0.3818,0.0592,-22.2332,-7.49805238025536,0.7534111953873852,Pathogenic,0.961,pathogenic,-4.265,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251G,NP_000537:p.Ile251Gly,,,,,saturation_mutlist,,,,,,,,5.38409,2.8282715606689455,,5.334019051265051,,5.3590545256325255,,Destabilizing,Destabilizing,,Destabilizing,0.4638873481738174,,0.4591981238331175,1.38673,,4.88142234392278,,3.13407617196139,,Uncertain,,Destabilizing,,0.10594617398347658,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.5115,0.0592,-22.2332,-6.25203367962597,0.8689690696447354,Pathogenic,0.9989,pathogenic,-4.768,available,https://doi.org/10.1101/2022.10.22.513328 +I251H,NP_000537:p.Ile251His,,,,,saturation_mutlist,,,,,,,,6.04009,2.8074985694885255,,2.8656816550286464,,4.452885827514323,,Uncertain,Destabilizing,,Destabilizing,0.5138255803051452,,0.27101123799395804,5.45588,,2.706461373489423,,4.081170686744711,,Uncertain,,Destabilizing,,0.097253770901719,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.5114,0.0592,-22.2332,-7.56701182597447,0.8625239988462694,Pathogenic,0.9996,pathogenic,-4.687,available,https://doi.org/10.1101/2022.10.22.513328 +I251K,NP_000537:p.Ile251Lys,,,,,saturation_mutlist,,,,,,,,5.40194,2.8654040813446047,,5.189414055286115,,5.295677027643057,,Destabilizing,Destabilizing,,Destabilizing,0.4331570577794969,,0.7865845543622582,2.31485,,4.237882308756574,,3.276366154378287,,Uncertain,,Destabilizing,,0.2655675628775315,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.5183,0.0592,-22.2332,-7.82977005918113,0.8635992466692368,Pathogenic,0.999,pathogenic,-4.786,available,https://doi.org/10.1101/2022.10.22.513328 +I251L,NP_000537:p.Ile251Leu,"hg19,17:g.7577530T>G, hg19,17:g.7674212T>G, hg38,17:g.7674212T>G",,,0.882,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182937,Pathogenic/Likely pathogenic,2,,,,,0.89899,0.2534980583190918,0.9466,0.7396869049298314,0.922795,0.8193384524649157,Neutral,Neutral,Neutral,Neutral,Neutral,0.4244898241077795,1.0576342265011407,0.058814777659559225,-0.95557,1.3189333333333333,0.6761887632135645,0.18168166666666663,-0.13969061839321778,Neutral,Neutral,Neutral,Neutral,0.14388184998656214,0.05141208743777544,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.306,0.0592,-22.2332,-3.66756218112283,0.2763584856273345,Benign,0.616,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251M,NP_000537:p.Ile251Met,"hg19,17:g.7577528G>C, hg38,17:g.7674210G>C",,,0.779,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",485046,Uncertain significance,2,,,,,0.73965,0.9074701690673828,0.9133800000000001,1.514234112391348,0.8265150000000001,1.126942056195674,Neutral,Neutral,Neutral,Neutral,Neutral,0.3485925612227268,1.1137729314661344,0.08468175906799098,-1.10043,1.3453533333333334,1.4682468052090563,0.12246166666666669,0.18390840260452812,Neutral,Neutral,Neutral,Neutral,0.16239500861240228,0.13050628233895864,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.3117,0.0592,-22.2332,-3.71680218621941,0.707595092617297,Pathogenic,0.794,pathogenic,-3.876,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251N,NP_000537:p.Ile251Asn,"hg19,17:g.7577528_7577529delinsAT, hg19,17:g.7577529A>T, hg19,17:g.7674211A>T, hg38,17:g.7674210_7674211delinsAT, hg38,17:g.7674211A>T",,,0.927,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528254,Conflicting classifications of pathogenicity,1,,,,,4.22793,3.03262526512146,3.43118,3.108412135176639,3.829555,3.6681710675883195,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.4836542499768172,0.9295968270528181,0.25102341162537845,2.14042,3.4520399999999998,2.7637507735852807,2.79623,2.4520853867926404,Uncertain,Uncertain,Uncertain,Uncertain,0.021035061207422174,0.09902245882628714,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.4579,0.0592,-22.2332,-7.82977005918113,0.8695468387105436,Pathogenic,0.9968,pathogenic,-4.614,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251P,NP_000537:p.Ile251Pro,,,,,saturation_mutlist,,,,,,,,4.33213,2.947836456298828,,6.82326390351428,,5.57769695175714,,Destabilizing,Destabilizing,,Destabilizing,0.42429336029356646,,0.2021909753188801,2.77006,,5.5088702179307925,,4.139465108965396,,Uncertain,,Destabilizing,,0.7787069159441682,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.5649,0.0592,-22.2332,-7.82977005918113,0.8663255821895334,Pathogenic,0.997,pathogenic,-4.614,available,https://doi.org/10.1101/2022.10.22.513328 +I251Q,NP_000537:p.Ile251Gln,,,,,saturation_mutlist,,,,,,,,3.57836,2.8373033142089845,,3.173620217474692,,3.375990108737346,,Destabilizing,Destabilizing,,Destabilizing,0.4725292228621711,,0.22608664089479988,1.26755,,2.7163511555511497,,1.9919505777755748,,Uncertain,,Neutral,,0.053194578636591695,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.4855,0.0592,-22.2332,-7.82977005918113,0.8680397080608632,Pathogenic,0.9991,pathogenic,-4.678,available,https://doi.org/10.1101/2022.10.22.513328 +I251R,NP_000537:p.Ile251Arg,,,,,saturation_mutlist,,,,,,,,7.48112,2.8543106079101563,,4.293818624254828,,5.887469312127414,,Destabilizing,Destabilizing,,Destabilizing,0.4075684278415996,,0.695012340634685,5.83299,,3.401383870082796,,4.617186935041397,,Destabilizing,,Destabilizing,,0.2702423654892883,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,neutral,,-0.5451,0.0592,-22.2332,-7.82977005918113,0.8585205005635097,Pathogenic,0.9986,pathogenic,-4.748,available,https://doi.org/10.1101/2022.10.22.513328 +I251S,NP_000537:p.Ile251Ser,"hg19,17:g.7577529A>C, hg19,17:g.7674211A>C, hg38,17:g.7674211A>C",,0.0,0.959,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182967,Conflicting classifications of pathogenicity,1,,,,,4.77636,2.8092541885375977,4.0659833333333335,4.126696623910594,4.421171666666667,4.451528311955297,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.47424587342077784,0.9338139642110498,0.4262335827523647,1.23588,4.2466,3.720081528181162,2.74124,2.477980764090581,Uncertain,Uncertain,Uncertain,Uncertain,0.13064211189352412,0.22385685479247114,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.4614,0.0592,-22.2332,-6.17822887715965,0.8606346375179728,Pathogenic,0.992,pathogenic,-4.532,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251T,NP_000537:p.Ile251Thr,"hg19,17:g.7577529A>G, hg19,17:g.7674211A>G, hg38,17:g.7674211A>G",,,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",439320,Conflicting classifications of pathogenicity,1,,,,,3.25288,2.3000664615631106,2.20329,2.8379169426657938,2.728085,3.0453984713328968,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,0.427634220287265,0.43445372419472567,0.32114984606232005,1.01038,2.8895700000000004,2.448691889834542,1.9499750000000002,1.729535944917271,Uncertain,Uncertain,Neutral,Neutral,0.40628113058160437,0.1419894470776415,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.3053,0.0592,-7.9454,-4.31668056163262,0.264674153989896,Benign,0.9767,pathogenic,-3.796,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251V,NP_000537:p.Ile251Val,"hg19,17:g.7577530T>C, hg38,17:g.7674212T>C",,,0.856,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1759315,Uncertain significance,2,,,,,1.29323,0.6094668579101562,0.67415,0.937360633967088,0.9836900000000001,1.115295316983544,Neutral,Neutral,Neutral,Neutral,Neutral,0.18035062854544792,0.17153809508871978,0.08830111935536898,-0.09447,0.9493166666666667,0.6787825652930396,0.4274233333333334,0.2921562826465198,Neutral,Neutral,Neutral,Neutral,0.1233253546067835,0.2578416651975804,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,uncertain,,-0.1983,0.0592,-8.9453,-2.99602757994519,0.0454933653739958,Benign,0.3679,ambiguous,-3.561,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251W,NP_000537:p.Ile251Trp,,,,,saturation_mutlist,,,,,,,,12.43803,1.8922210121154786,,3.0508128305782165,,7.744421415289108,,Destabilizing,Uncertain,,Destabilizing,0.523707140385763,,0.6237718440488106,12.94999,,2.6473665131588144,,7.798678256579407,,Uncertain,,Destabilizing,,0.29267750710598556,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,neutral,,-0.4707,0.0592,-22.2332,-7.56701182597447,0.8692122146259679,Pathogenic,0.9995,pathogenic,-4.824,available,https://doi.org/10.1101/2022.10.22.513328 +I251Y,NP_000537:p.Ile251Tyr,,,,,saturation_mutlist,,,,,,,,9.6287,1.9433843302726745,,2.7870636300968123,,6.207881815048406,,Uncertain,Uncertain,,Destabilizing,0.5366750755616386,,0.4727995668168087,8.1685,,2.710725016864931,,5.439612508432465,,Uncertain,,Destabilizing,,0.11207299096998384,0.15,0.446,1.745,1.577,,True,0.15,,neutral,neutral,neutral,,True,1.745,,neutral,neutral,neutral,neutral,,-0.4796,0.0592,-22.2332,-7.56701182597447,0.8702599703438643,Pathogenic,0.9979,pathogenic,-4.694,available,https://doi.org/10.1101/2022.10.22.513328 +L252A,NP_000537:p.Leu252Ala,,,,,saturation_mutlist,,,,,,,,2.46763,1.7590824890136718,,2.42429420209447,,2.445962101047235,,Uncertain,Uncertain,,Uncertain,0.1747543659415806,,0.19910162300932457,1.61089,,2.2011582349776475,,1.9060241174888237,,Uncertain,,Neutral,,0.3854163142600623,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.3924,0.295,-22.239,-5.32307947185743,0.2046868068149483,Benign,0.615,pathogenic,-3.95,available,https://doi.org/10.1101/2022.10.22.513328 +L252C,NP_000537:p.Leu252Cys,,,,,saturation_mutlist,,,,,,,,2.01118,0.6894156146049499,,2.672549111996799,,2.3418645559983995,,Uncertain,Neutral,,Uncertain,0.15304087103938152,,0.218426409841118,1.39769,,2.6467312192747223,,2.0222106096373613,,Uncertain,,Uncertain,,0.3684815387996229,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.3816,0.295,-22.239,-6.0620096481428,0.4233953826179751,Uncertain,0.6188,pathogenic,-4.089,available,https://doi.org/10.1101/2022.10.22.513328 +L252D,NP_000537:p.Leu252Asp,,,,,saturation_mutlist,,,,,,,,3.2754,2.8544908714294435,,3.162811322874639,,3.2191056614373195,,Destabilizing,Destabilizing,,Destabilizing,0.2680433732866237,,0.27901380603577575,3.92343,,3.3210738204168053,,3.6222519102084028,,Destabilizing,,Destabilizing,,0.6318223090950512,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.5139,0.295,-22.239,-4.7962226105534,0.2743200689577354,Benign,0.9677,pathogenic,-4.043,available,https://doi.org/10.1101/2022.10.22.513328 +L252E,NP_000537:p.Leu252Glu,,,,,saturation_mutlist,,,,,,,,2.97286,2.1517229175567625,,2.5221819168770847,,2.7475209584385425,,Uncertain,Destabilizing,,Uncertain,0.3306931897472512,,0.24630024534165595,3.39098,,2.885350088193515,,3.1381650440967572,,Uncertain,,Destabilizing,,0.533197504561565,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.4819,0.295,-22.239,-4.43207227029161,0.0769919057840972,Benign,0.7475,pathogenic,-4.002,available,https://doi.org/10.1101/2022.10.22.513328 +L252F,NP_000537:p.Leu252Phe,"hg19,17:g.7577527G>A, hg38,17:g.7674209G>A",,,0.716,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1053765,Uncertain significance,1,,,,,1.08325,0.8522373104095459,0.8442166666666667,0.9181959682713314,0.9637333333333333,1.0007229841356657,Neutral,Neutral,Neutral,Neutral,Neutral,0.3420158512348115,0.5615585873461666,0.39463239635143255,1.59957,2.0526066666666662,1.277399945487521,1.826088333333333,1.4384849727437605,Uncertain,Neutral,Neutral,Neutral,0.6196130261345023,0.26269104925119235,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.3258,0.295,-22.239,-6.52101244700316,0.5923473637238145,Uncertain,0.3774,ambiguous,-3.91,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L252G,NP_000537:p.Leu252Gly,,,,,saturation_mutlist,,,,,,,,3.57522,2.8503266525268556,,4.273043172151895,,3.9241315860759474,,Destabilizing,Destabilizing,,Destabilizing,0.24516103265060268,,0.2920323655210934,2.18813,,3.870196063207088,,3.0291630316035443,,Uncertain,,Destabilizing,,0.5186696031732089,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.4672,0.295,-22.239,-7.20169181714271,0.4922913796591854,Uncertain,0.9311,pathogenic,-4.297,available,https://doi.org/10.1101/2022.10.22.513328 +L252H,NP_000537:p.Leu252His,"hg19,17:g.7577526A>T, hg38,17:g.7674208A>T",,,0.914,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.88998,1.549707818031311,2.049773333333333,1.7923124289796588,2.4698766666666665,2.3411462144898296,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.29380382247589076,0.33437875294674785,0.26583243878070495,2.85517,3.20907,1.9899956683041726,3.03212,2.4225828341520863,Uncertain,Uncertain,Destabilizing,Uncertain,0.7227792780648875,0.3128732284388728,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.4347,0.295,-22.239,-6.10553946518275,0.3556995624617788,Uncertain,0.6136,pathogenic,-3.932,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L252I,NP_000537:p.Leu252Ile,,,,,saturation_mutlist,,,,,,,,1.35807,-0.2942686605453491,,0.9293876860074836,,1.1437288430037418,,Neutral,Neutral,,Neutral,0.5131247014100102,,0.1609755850433361,1.14722,,1.295498895349543,,1.2213594476747716,,Neutral,,Neutral,,0.4404443243466665,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,uncertain,,-0.1885,0.295,-6.9513,-0.565823379800516,0.0124868456697013,Benign,0.09,benign,-3.56,available,https://doi.org/10.1101/2022.10.22.513328 +L252K,NP_000537:p.Leu252Lys,,,,,saturation_mutlist,,,,,,,,1.76963,1.2593087768554687,,2.7097442582943585,,2.239687129147179,,Uncertain,Uncertain,,Uncertain,0.2522579801181511,,0.24744480595838936,1.54246,,2.4157851430123993,,1.9791225715061995,,Uncertain,,Neutral,,0.629377861404693,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,uncertain,,-0.481,0.295,-22.239,-5.12571930820422,0.0288233196274121,Benign,0.7311,pathogenic,-3.955,available,https://doi.org/10.1101/2022.10.22.513328 +L252M,NP_000537:p.Leu252Met,,,,,saturation_mutlist,,,,,,,,0.46051,0.6064815950393677,,1.1526990427740833,,0.8066045213870416,,Neutral,Neutral,,Neutral,0.11485330659894957,,0.1865001912121577,0.11688,,1.2828655585110686,,0.6998727792555344,,Neutral,,Neutral,,0.07430832155798647,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,uncertain,,-0.2139,0.295,-7.3663,-2.34504626988143,0.0003431671763887,Benign,0.1395,benign,-3.506,available,https://doi.org/10.1101/2022.10.22.513328 +L252N,NP_000537:p.Leu252Asn,,,,,saturation_mutlist,,,,,,,,2.49859,2.0717293500900267,,2.3248202927380492,,2.411705146369025,,Uncertain,Destabilizing,,Uncertain,0.29616240917171766,,0.17444797646754928,2.20047,,2.10912047147549,,2.154795235737745,,Uncertain,,Uncertain,,0.3997255506991797,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.4602,0.295,-22.239,-4.34037649175041,0.3507042372828399,Uncertain,0.7671,pathogenic,-4.073,available,https://doi.org/10.1101/2022.10.22.513328 +L252P,NP_000537:p.Leu252Pro,"hg19,17:g.7577526A>G, hg19,17:g.7674208A>G, hg38,17:g.7674208A>G",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12350,Conflicting classifications of pathogenicity,1,,,,,4.68149,3.1430355739593505,6.095009999999999,6.827807074494319,5.388249999999999,5.75464853724716,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.31813915527160813,0.7733876681630416,0.8629971735837388,6.09117,6.123016666666666,7.06337919599503,6.107093333333333,6.577274597997516,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.877528388993136,1.2122707376990804,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.4758,0.295,-22.239,-7.20169181714271,0.7946937304955756,Pathogenic,0.9967,pathogenic,-4.263,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L252Q,NP_000537:p.Leu252Gln,,,,,saturation_mutlist,,,,,,,,2.28948,1.533111982345581,,2.0611080481044683,,2.175294024052234,,Uncertain,Uncertain,,Uncertain,0.22760360328076276,,0.2062874771617444,1.99028,,2.1605903590182893,,2.0754351795091446,,Uncertain,,Uncertain,,0.27561196047085645,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.3453,0.295,-8.9511,-3.31028047262029,0.0104071968439334,Benign,0.3879,ambiguous,-3.607,available,https://doi.org/10.1101/2022.10.22.513328 +L252R,NP_000537:p.Leu252Arg,,,,,saturation_mutlist,,,,,,,,2.26207,1.1752323031425476,,2.0626933092258195,,2.1623816546129095,,Uncertain,Uncertain,,Uncertain,0.3040155146223865,,0.2994664330637491,1.83616,,1.8436675490415764,,1.839913774520788,,Neutral,,Neutral,,0.501725585681334,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.4047,0.295,-8.9511,-5.1513623328678,0.0520242855241158,Benign,0.5934,pathogenic,-3.996,available,https://doi.org/10.1101/2022.10.22.513328 +L252S,NP_000537:p.Leu252Ser,,,,,saturation_mutlist,,,,,,,,3.2093,1.9101737546920776,,3.2358166354092237,,3.2225583177046118,,Destabilizing,Uncertain,,Destabilizing,0.22249533610188452,,0.2039192015605342,1.99769,,3.0087070734792483,,2.503198536739624,,Uncertain,,Uncertain,,0.4636943599296318,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.3498,0.295,-7.9512,-4.27254861360225,0.0576205092532352,Benign,0.6428,pathogenic,-3.75,available,https://doi.org/10.1101/2022.10.22.513328 +L252T,NP_000537:p.Leu252Thr,,,,,saturation_mutlist,,,,,,,,2.61037,1.2603797221183777,,2.225487715361974,,2.417928857680987,,Uncertain,Uncertain,,Uncertain,0.3611964518895225,,0.202730631141623,2.18795,,2.371985979859799,,2.2799679899298995,,Uncertain,,Uncertain,,0.20972920483811897,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.3955,0.295,-22.239,-6.0620096481428,0.1699895125981999,Benign,0.4968,ambiguous,-4.024,available,https://doi.org/10.1101/2022.10.22.513328 +L252V,NP_000537:p.Leu252Val,"hg19,17:g.7577527G>C, hg38,17:g.7674209G>C",,,0.607,"ClinVar,saturation_mutlist",1759470,Conflicting classifications of pathogenicity,1,,,,,1.46967,-0.005154557228088379,1.1675733333333334,1.1842131757808174,1.3186216666666666,1.3269415878904087,Neutral,Neutral,Neutral,Neutral,Neutral,0.4329690284828248,0.9131870925257077,0.11623901145383371,0.92914,0.71111,1.2981796905855691,0.820125,1.1136598452927846,Neutral,Neutral,Neutral,Neutral,0.2684281044649883,0.2945555869178246,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.2218,0.295,-6.3663,-0.444021344648924,3.825660962187732e-05,Benign,0.0882,benign,-3.461,available,https://doi.org/10.1101/2022.10.22.513328 +L252W,NP_000537:p.Leu252Trp,,,,,saturation_mutlist,,,,,,,,2.47841,1.005120313167572,,0.9697682318386649,,1.7240891159193323,,Uncertain,Uncertain,,Neutral,0.27704744499816414,,0.41039055063207003,2.1935,,1.2338074540933663,,1.7136537270466832,,Uncertain,,Neutral,,0.4043931070892286,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.425,0.295,-22.239,-6.52101244700316,0.8191540733618617,Pathogenic,0.6795,pathogenic,-4.402,available,https://doi.org/10.1101/2022.10.22.513328 +L252Y,NP_000537:p.Leu252Tyr,,,,,saturation_mutlist,,,,,,,,1.74522,0.9483983063697815,,1.3486646550963146,,1.5469423275481573,,Neutral,Neutral,,Neutral,0.37290775080279054,,0.4080737245151511,2.63225,,1.7268789660548418,,2.179564483027421,,Uncertain,,Uncertain,,0.3948247650349362,8.319,3.854,6.095,3.83,,True,8.319,,neutral,neutral,neutral,,True,6.095,,neutral,neutral,neutral,neutral,,-0.4179,0.295,-22.239,-5.50703915075823,0.2963794984336334,Benign,0.6985,pathogenic,-4.05,available,https://doi.org/10.1101/2022.10.22.513328 +T253A,NP_000537:p.Thr253Ala,"hg19,17:g.7577524T>C, hg19,17:g.7674206T>C, hg38,17:g.7674206T>C",,,0.854,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",827132,Pathogenic/Likely pathogenic,2,,,,,1.824,0.3911074769496918,1.5061233333333333,1.0473116443437238,1.6650616666666667,1.4356558221718618,Neutral,Neutral,Neutral,Neutral,Neutral,0.18782048705387472,0.19752167920396882,0.612410543417756,0.5163,1.50964,0.6308424225445893,1.0129700000000001,0.5735712112722946,Neutral,Neutral,Neutral,Neutral,0.2506133042491293,0.11707829745144649,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.1215,1.2519,-5.3663,-1.81376137317371,0.0002533113383874,Benign,0.5944,pathogenic,-3.478,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T253C,NP_000537:p.Thr253Cys,,,,,saturation_mutlist,,,,,,,,0.80763,-0.6493332147598266,,1.00661501776162,,0.9071225088808099,,Neutral,Neutral,,Neutral,0.302210550405172,,0.36990577354008936,-0.15012,,0.9376215925070136,,0.3937507962535068,,Neutral,,Neutral,,0.3010384100252694,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.2434,1.2519,-22.239,-3.02168511213109,0.7445565640752505,Pathogenic,0.8623,pathogenic,-4.226,available,https://doi.org/10.1101/2022.10.22.513328 +T253D,NP_000537:p.Thr253Asp,"hg19,17:g.7577523_7577524delinsTC",,,,"cBioPortal,saturation_mutlist",,,,,,,,2.03661,2.0476880359649656,1.9730166666666669,2.474393079762501,2.0048133333333333,2.2555015398812506,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,0.3965614404089131,0.5777332928109841,0.46794993094647497,1.33592,1.646823333333333,2.2809007618583945,1.4913716666666665,1.8084103809291974,Neutral,Uncertain,Neutral,Neutral,0.5656878501631639,0.25843473734767575,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,uncertain,,-0.3232,1.2519,-22.239,-6.06791127463505,0.8127573065977443,Pathogenic,0.9969,pathogenic,-4.599,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T253E,NP_000537:p.Thr253Glu,,,,,saturation_mutlist,,,,,,,,1.49861,1.7217485809326172,,2.1394150824501614,,1.8190125412250806,,Uncertain,Uncertain,,Neutral,0.4345961308257016,,0.6391735822132457,0.86284,,1.6351144512609777,,1.248977225630489,,Neutral,,Neutral,,0.11515322915646757,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.2985,1.2519,-22.239,-6.06791127463505,0.7965350861489514,Pathogenic,0.998,pathogenic,-4.6,available,https://doi.org/10.1101/2022.10.22.513328 +T253F,NP_000537:p.Thr253Phe,,,,,saturation_mutlist,,,,,,,,1.67734,-0.28853469133377074,,-0.33792036135305265,,0.6697098193234737,,Neutral,Neutral,,Neutral,0.5778366422620296,,1.0508199974322652,4.47512,,-0.3146948190156414,,2.0802125904921795,,Uncertain,,Uncertain,,0.5549931744281692,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.3148,1.2519,-22.239,-6.20497469977993,0.6948569202578241,Pathogenic,0.9932,pathogenic,-4.328,available,https://doi.org/10.1101/2022.10.22.513328 +T253G,NP_000537:p.Thr253Gly,,,,,saturation_mutlist,,,,,,,,3.53185,1.5000085973739623,,3.5405480440693444,,3.536199022034672,,Destabilizing,Uncertain,,Destabilizing,0.29805107889356686,,0.5992406192911782,1.79395,,2.944179839058606,,2.3690649195293028,,Uncertain,,Uncertain,,0.05849295746099468,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.2811,1.2519,-22.239,-6.43928617269642,0.8122163792423643,Pathogenic,0.9011,pathogenic,-4.421,available,https://doi.org/10.1101/2022.10.22.513328 +T253H,NP_000537:p.Thr253His,,,,,saturation_mutlist,,,,,,,,2.96243,1.0974275022745132,,0.9039064830748743,,1.9331682415374372,,Uncertain,Uncertain,,Neutral,0.42095845251157477,,0.9802253904286066,4.39908,,0.5019580337827078,,2.4505190168913535,,Uncertain,,Uncertain,,0.2607234140608173,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.2951,1.2519,-22.239,-6.20497469977993,0.8589926606828056,Pathogenic,0.9883,pathogenic,-4.534,available,https://doi.org/10.1101/2022.10.22.513328 +T253I,NP_000537:p.Thr253Ile,"hg19,17:g.7577523G>A, hg19,17:g.7674205G>A, hg38,17:g.7674205G>A",,,0.790,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",837688,Conflicting classifications of pathogenicity,1,,,,,-1.07831,-1.4417189931869507,-1.4538533333333332,-1.114456977307681,-1.2660816666666665,-1.0963834886538404,Neutral,Neutral,Uncertain,Neutral,Neutral,0.4687674617255399,0.38712800039378303,0.20166938253677638,-1.40705,-1.0971633333333333,-1.189688378758999,-1.2521066666666667,-1.2983691893794993,Neutral,Neutral,Neutral,Neutral,1.1239577966671563,0.24415594796585882,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.1243,1.2519,-0.8428,-1.96920395385682,0.0004182508112196,Benign,0.9634,pathogenic,-3.404,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T253K,NP_000537:p.Thr253Lys,,,,,saturation_mutlist,,,,,,,,2.40744,1.4660882139205933,,3.675366424772483,,3.0414032123862413,,Uncertain,Uncertain,,Destabilizing,0.4631745610458721,,1.5494964969414944,2.81837,,1.9518632211742568,,2.3851166105871284,,Uncertain,,Uncertain,,0.7101486087663405,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.2907,1.2519,-22.239,-6.43928617269642,0.8362232245901847,Pathogenic,0.9982,pathogenic,-4.542,available,https://doi.org/10.1101/2022.10.22.513328 +T253L,NP_000537:p.Thr253Leu,,,,,saturation_mutlist,,,,,,,,-0.98511,-1.013582582473755,,-0.9888182691277313,,-0.9869641345638657,,Neutral,Uncertain,,Neutral,0.6993794694310841,,0.26954315219029057,-1.88773,,-1.3331659136707987,,-1.6104479568353993,,Neutral,,Neutral,,0.32210989449980854,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.2854,1.2519,-22.239,-2.73886578153278,0.0310664025945029,Benign,0.8156,pathogenic,-3.754,available,https://doi.org/10.1101/2022.10.22.513328 +T253M,NP_000537:p.Thr253Met,,,,,saturation_mutlist,,,,,,,,-1.1746,-0.5768831014633179,,-0.22786274567726342,,-0.7012313728386318,,Neutral,Neutral,,Neutral,0.5561320481326304,,0.4580845399143232,-1.52926,,-0.46102747750252066,,-0.9951437387512604,,Neutral,,Neutral,,0.3934593600700987,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.1846,1.2519,-8.9511,-1.69755716348408,0.1947065243984903,Benign,0.7455,pathogenic,-3.724,available,https://doi.org/10.1101/2022.10.22.513328 +T253N,NP_000537:p.Thr253Asn,"hg19,17:g.7577523G>T, hg19,17:g.7674205G>T, hg38,17:g.7674205G>T",,,0.895,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",505571,Uncertain significance,2,,,,,1.65064,1.513306360244751,1.17891,1.1284288734177765,1.4147750000000001,1.3895344367088884,Neutral,Neutral,Uncertain,Neutral,Neutral,0.4003965500793378,0.9369164117465336,0.46478380141109554,0.68362,1.0247133333333334,0.8777424346152044,0.8541666666666667,0.7806812173076022,Neutral,Neutral,Neutral,Neutral,0.6019965034413037,0.41615043835632526,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,uncertain,,-0.1954,1.2519,-8.9511,-4.14012922934797,0.5558806593975456,Uncertain,0.9499,pathogenic,-4.141,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T253P,NP_000537:p.Thr253Pro,"hg19,17:g.7577524T>G, hg19,17:g.7674206T>G, hg38,17:g.7674206T>G",,,0.942,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3148769,Conflicting classifications of pathogenicity,1,,,,,3.83775,1.700634126663208,3.11837,4.894380303529834,3.47806,4.366065151764917,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.34248281711865225,0.8485225786035395,0.892349128891028,4.16541,2.924716666666667,4.62681074004768,3.5450633333333332,4.396110370023839,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.4578607871637647,0.23669572698464003,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,uncertain,,-0.3719,1.2519,-22.239,-6.43928617269642,0.833904233711422,Pathogenic,0.9882,pathogenic,-4.478,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T253Q,NP_000537:p.Thr253Gln,,,,,saturation_mutlist,,,,,,,,1.73917,1.2168755996227265,,1.1300869068625043,,1.4346284534312521,,Neutral,Uncertain,,Neutral,0.46033147328416274,,0.5143232273924755,0.59226,,0.6777097313528325,,0.6349848656764163,,Neutral,,Neutral,,0.16862054829193004,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.2727,1.2519,-22.239,-6.06791127463505,0.8521738256046161,Pathogenic,0.9914,pathogenic,-4.437,available,https://doi.org/10.1101/2022.10.22.513328 +T253R,NP_000537:p.Thr253Arg,,,,,saturation_mutlist,,,,,,,,5.83374,1.4107751607894898,,2.4241743222974024,,4.128957161148701,,Uncertain,Uncertain,,Destabilizing,0.4177216991997627,,1.431609214823502,5.7492,,0.8624331909341123,,3.305816595467056,,Uncertain,,Destabilizing,,0.6210217324242383,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.2935,1.2519,-22.239,-6.43928617269642,0.842563544816896,Pathogenic,0.9976,pathogenic,-4.608,available,https://doi.org/10.1101/2022.10.22.513328 +T253S,NP_000537:p.Thr253Ser,"hg19,17:g.7577523G>C, hg19,17:g.7577524T>A, hg38,17:g.7674205G>C, hg38,17:g.7674206T>A",,,"0.851, 0.854","cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.87383,0.6663280844688415,1.9051033333333331,2.074196340751696,1.8894666666666666,1.974013170375848,Neutral,Uncertain,Neutral,Neutral,Neutral,0.2100317424178989,0.1217180538055971,0.6532927338603715,1.00797,1.8515866666666667,1.714857166549394,1.4297783333333334,1.361413583274697,Neutral,Neutral,Neutral,Neutral,0.0940664645639218,0.12244513428908878,0.028,0.139,5.25,4.03,,True,0.028,,neutral,,,,True,5.25,,neutral,,,neutral,,-0.1713,1.2519,-22.239,-4.19430095203731,0.0191903966630435,Benign,0.6338,pathogenic,-4.095,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T253V,NP_000537:p.Thr253Val,,,,,saturation_mutlist,,,,,,,,-0.76867,-1.2834442019462586,,-1.0766199926626847,,-0.9226449963313423,,Neutral,Uncertain,,Neutral,0.3219801478654257,,0.16275184038378812,-1.11345,,-0.9317066618087163,,-1.0225783309043581,,Neutral,,Neutral,,0.18643762159541247,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.1389,1.2519,-6.1439,-1.18688464182934,0.0245489013375776,Benign,0.8351,pathogenic,-3.52,available,https://doi.org/10.1101/2022.10.22.513328 +T253W,NP_000537:p.Thr253Trp,,,,,saturation_mutlist,,,,,,,,10.65225,-0.07158730268478393,,1.1721336062024996,,5.91219180310125,,Uncertain,Neutral,,Destabilizing,0.7236908355549392,,1.5708712605432449,10.78636,,0.12333171062459924,,5.4548458553123,,Uncertain,,Destabilizing,,1.084933479210394,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.3077,1.2519,-22.239,-6.20497469977993,0.8707838857818175,Pathogenic,0.9991,pathogenic,-4.712,available,https://doi.org/10.1101/2022.10.22.513328 +T253Y,NP_000537:p.Thr253Tyr,,,,,saturation_mutlist,,,,,,,,4.2681,0.06779818773269654,,0.8180879811388645,,2.543093990569432,,Uncertain,Neutral,,Uncertain,0.5654579756325463,,1.4979408361454103,7.74213,,0.36940772787609727,,4.055768863938049,,Uncertain,,Destabilizing,,0.8402743761024656,0.028,0.139,5.25,4.03,,True,0.028,,uncertain,,,,True,5.25,,uncertain,,,neutral,,-0.3163,1.2519,-22.239,-6.20497469977993,0.8210330299668427,Pathogenic,0.9972,pathogenic,-4.578,available,https://doi.org/10.1101/2022.10.22.513328 +I254A,NP_000537:p.Ile254Ala,,,,,saturation_mutlist,,,,,,,,3.42721,2.147027702331543,,2.95677730319361,,3.191993651596805,,Uncertain,Destabilizing,,Destabilizing,0.18162839727189847,,0.23251716674860187,2.67798,,2.7822687067045067,,2.7301243533522532,,Uncertain,,Uncertain,,0.08513113603864483,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.4224,0.0421,-22.2361,-5.67250387452748,0.7701140885175584,Pathogenic,0.9717,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328 +I254C,NP_000537:p.Ile254Cys,,,,,saturation_mutlist,,,,,,,,2.68801,1.1568772649765016,,2.9647678406281828,,2.8263889203140913,,Uncertain,Uncertain,,Uncertain,0.13627928244588283,,0.09631885718791826,2.18531,,2.690163736981416,,2.437736868490708,,Uncertain,,Uncertain,,0.14539148978743785,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.4024,0.0421,-22.2361,-7.00135748934014,0.8498705233904261,Pathogenic,0.987,pathogenic,-4.446,available,https://doi.org/10.1101/2022.10.22.513328 +I254D,NP_000537:p.Ile254Asp,"hg19,17:g.7577520_7577521delinsTC, hg19,17:g.7674202_7674203delinsTC, hg38,17:g.7674202_7674203delinsTC",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,2.65583,2.464707384109497,4.12857,3.958142799564937,3.3922,3.3069863997824687,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.3951867253441825,0.21392964560029232,0.2972285054454665,3.69888,4.284126666666666,3.8000291311907852,3.991503333333333,3.749454565595393,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.5836427775807923,0.14119628923916533,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.5464,0.0421,-22.2361,-7.91994321044374,0.8702608441690488,Pathogenic,0.9995,pathogenic,-4.818,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254E,NP_000537:p.Ile254Glu,,,,,saturation_mutlist,,,,,,,,3.31838,2.4443743133544924,,3.354213767579187,,3.3362968837895934,,Destabilizing,Destabilizing,,Destabilizing,0.32218835510735805,,0.2768309447893216,3.66933,,3.2554098311470145,,3.4623699155735075,,Destabilizing,,Destabilizing,,0.1273581451133162,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.5274,0.0421,-22.2361,-7.91994321044374,0.8012481145341709,Pathogenic,0.9982,pathogenic,-4.658,available,https://doi.org/10.1101/2022.10.22.513328 +I254F,NP_000537:p.Ile254Phe,"hg19,17:g.7577521T>A, hg19,17:g.7674203T>A, hg38,17:g.7674203T>A",,,0.942,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,5.17602,1.369680781364441,3.140473333333333,1.3371076851602217,4.158246666666667,3.256563842580111,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.2643110233482852,1.4971020575394614,0.3071015879557391,5.13917,2.68991,1.4751287992876996,3.9145399999999997,3.30714939964385,Uncertain,Uncertain,Destabilizing,Destabilizing,1.5169431184018294,0.2934992668843968,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.3834,0.0421,-22.2361,-7.91994321044374,0.8708591134846212,Pathogenic,0.935,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254G,NP_000537:p.Ile254Gly,,,,,saturation_mutlist,,,,,,,,4.57682,2.812458038330078,,4.904190759889899,,4.740505379944949,,Destabilizing,Destabilizing,,Destabilizing,0.3699052042855996,,0.42269427988265384,3.94696,,4.422666239843518,,4.184813119921759,,Destabilizing,,Destabilizing,,0.25124180339696145,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.5131,0.0421,-22.2361,-7.91994321044374,0.8702426006797316,Pathogenic,0.9979,pathogenic,-4.752,available,https://doi.org/10.1101/2022.10.22.513328 +I254H,NP_000537:p.Ile254His,,,,,saturation_mutlist,,,,,,,,6.00151,2.152955937385559,,2.41563873971703,,4.208574369858515,,Uncertain,Destabilizing,,Destabilizing,0.25993711343397047,,0.13121865554479453,6.11218,,2.3609821164389326,,4.236581058219467,,Uncertain,,Destabilizing,,0.19263413690566195,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.513,0.0421,-22.2361,-7.91994321044374,0.86878964668506,Pathogenic,0.9981,pathogenic,-4.634,available,https://doi.org/10.1101/2022.10.22.513328 +I254K,NP_000537:p.Ile254Lys,,,,,saturation_mutlist,,,,,,,,4.24162,2.566584734916687,,3.7227549837426253,,3.9821874918713127,,Destabilizing,Destabilizing,,Destabilizing,0.28560920427661385,,0.661508788950886,4.77535,,3.577866804121321,,4.17660840206066,,Destabilizing,,Destabilizing,,0.51472096400343,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,uncertain,,-0.5199,0.0421,-22.2361,-7.91994321044374,0.8704077092948044,Pathogenic,0.9979,pathogenic,-4.681,available,https://doi.org/10.1101/2022.10.22.513328 +I254L,NP_000537:p.Ile254Leu,"hg19,17:g.7577521T>G, hg38,17:g.7674203T>G",,,0.871,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.18259,0.7215896177291871,0.30124666666666666,0.5881186176558517,0.24191833333333335,0.3853543088279259,Neutral,Neutral,Neutral,Neutral,Neutral,0.17934639827497034,0.11657380275554576,0.16052018703041904,0.38284,0.91406,0.46015796863157177,0.64845,0.4214989843157859,Neutral,Neutral,Neutral,Neutral,0.0625460662232246,0.20394472427730584,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,uncertain,,-0.2398,0.0421,-8.9482,-4.22488625076884,0.1023629050292371,Benign,0.6108,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254M,NP_000537:p.Ile254Met,"hg19,17:g.7577519G>C, hg38,17:g.7674201G>C",,,0.877,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2135554,Uncertain significance,1,,,,,0.4004,1.2163958930969239,1.0850333333333333,1.3624312418868865,0.7427166666666667,0.8814156209434432,Neutral,Neutral,Uncertain,Neutral,Neutral,0.17362942632328307,0.38637643901022517,0.1405703957792026,0.76216,1.6772099999999999,1.3147301095632111,1.219685,1.0384450547816055,Neutral,Neutral,Neutral,Neutral,0.170109057567981,0.24545489001670057,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,uncertain,,-0.3133,0.0421,-22.2361,-4.75314403238212,0.869049203570615,Pathogenic,0.6518,pathogenic,-4.174,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254N,NP_000537:p.Ile254Asn,"hg19,17:g.7577519_7577520delinsAT, hg19,17:g.7577520A>T, hg19,17:g.7674202A>T, hg38,17:g.7674201_7674202delinsAT, hg38,17:g.7674202A>T",,,0.962,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2817584, 856299","Pathogenic, Pathogenic","1, 3",,,,,3.14816,2.4388651943206785,3.0473933333333334,2.8749227802276587,3.0977766666666664,3.0115413901138295,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.31944851465889346,0.10736480656569401,0.11881488067806525,3.03777,3.072226666666667,2.5552013155064404,3.0549983333333337,2.7964856577532204,Destabilizing,Uncertain,Destabilizing,Uncertain,0.29178686517540314,0.1717624844605488,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.4595,0.0421,-22.2361,-7.91994321044374,0.8610421676740224,Pathogenic,0.9911,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254P,NP_000537:p.Ile254Pro,,,,,saturation_mutlist,,,,,,,,5.48864,2.9310184574127196,,7.294672752392571,,6.391656376196286,,Destabilizing,Destabilizing,,Destabilizing,0.3640472546337394,,0.2087666193755772,3.92033,,5.075449131302778,,4.4978895656513895,,Destabilizing,,Destabilizing,,0.6407360887133358,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.5665,0.0421,-22.2361,-7.91994321044374,0.8642001975602676,Pathogenic,0.9989,pathogenic,-4.701,available,https://doi.org/10.1101/2022.10.22.513328 +I254Q,NP_000537:p.Ile254Gln,,,,,saturation_mutlist,,,,,,,,3.20177,2.349442272186279,,2.6064870010446355,,2.904128500522318,,Uncertain,Destabilizing,,Uncertain,0.290866078375704,,0.17920733820741522,3.30867,,2.5189086030203844,,2.9137893015101923,,Uncertain,,Uncertain,,0.21959555712853782,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.4871,0.0421,-22.2361,-7.91994321044374,0.8706040152119583,Pathogenic,0.9976,pathogenic,-4.595,available,https://doi.org/10.1101/2022.10.22.513328 +I254R,NP_000537:p.Ile254Arg,,,,,saturation_mutlist,,,,,,,,5.2462,2.588018226623535,,2.751717525399999,,3.998958762699999,,Uncertain,Destabilizing,,Destabilizing,0.2827824831108339,,0.5063051420082608,8.43057,,2.674973713818724,,5.552771856909362,,Uncertain,,Destabilizing,,0.40906034282268744,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.5467,0.0421,-22.2361,-7.91994321044374,0.8657925023713351,Pathogenic,0.9958,pathogenic,-4.64,available,https://doi.org/10.1101/2022.10.22.513328 +I254S,NP_000537:p.Ile254Ser,"hg19,17:g.7577520A>C, hg19,17:g.7674202A>C, hg38,17:g.7674202A>C",,0.0,0.953,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",659457,Conflicting classifications of pathogenicity,1,,,,,4.13837,2.278830714225769,3.54059,3.7456580709957312,3.83948,3.9420140354978654,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.2922016687473546,0.5924072952510515,0.33760498839777847,3.52578,3.4934266666666667,3.4255705916763843,3.5096033333333336,3.475675295838192,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.6426915482216607,0.23934081913799582,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.463,0.0421,-22.2361,-7.00135748934014,0.8406404354528518,Pathogenic,0.9848,pathogenic,-4.478,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254T,NP_000537:p.Ile254Thr,"hg19,17:g.7577520A>G, hg38,17:g.7674202A>G",,,0.954,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1759844,Pathogenic,3,,,,,3.06575,1.9305073738098144,2.535486666666667,2.5092213810138535,2.8006183333333334,2.7874856905069265,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.30799503096686515,0.2925283057908908,0.21552599298925745,2.47833,1.82494,2.213131514311149,2.151635,2.3457307571555743,Uncertain,Uncertain,Uncertain,Uncertain,0.49619653874918024,0.1271510886964106,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.3798,0.0421,-22.2361,-7.00135748934014,0.8677703314347418,Pathogenic,0.9725,pathogenic,-4.188,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254V,NP_000537:p.Ile254Val,"hg19,17:g.7577521T>C, hg38,17:g.7674203T>C",,1.5906090442e-05,0.780,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406605,Likely benign,3,,,,,1.1401,0.44005595207214354,0.20011333333333337,0.8141539473339842,0.6701066666666666,0.9771269736669921,Neutral,Neutral,Neutral,Neutral,Neutral,0.13497263888917133,0.5824715549182543,0.042173327875437025,0.56486,0.3091833333333333,0.7403359650934226,0.43702166666666664,0.6525979825467113,Neutral,Neutral,Neutral,Neutral,0.32571791817801826,0.26252213225432575,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.1999,0.0421,-8.9482,-2.63502144052448,0.0254825571047142,Benign,0.1871,benign,-3.418,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254W,NP_000537:p.Ile254Trp,,,,,saturation_mutlist,,,,,,,,9.32032,1.5526219606399536,,1.8261685982249096,,5.573244299112455,,Uncertain,Uncertain,,Destabilizing,0.2658182537659551,,0.3472733876322352,10.97545,,1.7447410337199594,,6.36009551685998,,Uncertain,,Destabilizing,,0.41773634671998966,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.4723,0.0421,-22.2361,-7.91994321044374,0.8693088227163428,Pathogenic,0.9976,pathogenic,-4.746,available,https://doi.org/10.1101/2022.10.22.513328 +I254Y,NP_000537:p.Ile254Tyr,,,,,saturation_mutlist,,,,,,,,7.77083,1.6097170448303222,,2.05582092615775,,4.913325463078875,,Uncertain,Uncertain,,Destabilizing,0.28634161785673595,,0.22648889887795798,7.77911,,2.014863128158389,,4.896986564079194,,Uncertain,,Destabilizing,,0.2532518922476514,2.235,1.775,1.185,1.268,,True,2.235,,neutral,neutral,neutral,,True,1.185,,neutral,neutral,neutral,neutral,,-0.4811,0.0421,-22.2361,-7.91994321044374,0.8639202665605441,Pathogenic,0.9919,pathogenic,-4.655,available,https://doi.org/10.1101/2022.10.22.513328 +I255A,NP_000537:p.Ile255Ala,,,,,saturation_mutlist,,,,,,,,4.35052,2.5860981941223145,,3.595631613632442,,3.9730758068162215,,Destabilizing,Destabilizing,,Destabilizing,0.20503567222489757,,0.12265498547316385,2.29951,,2.8201529690814624,,2.559831484540731,,Uncertain,,Uncertain,,0.26373939751312,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.291,1.4703,-22.239,-6.43911129997014,0.8308949374677067,Pathogenic,0.9732,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328 +I255C,NP_000537:p.Ile255Cys,,,,,saturation_mutlist,,,,,,,,3.39151,1.5217986440658569,,3.4318366624554972,,3.4116733312277487,,Destabilizing,Uncertain,,Destabilizing,0.1974605943193955,,0.08894945268159982,1.6726,,2.937001043088547,,2.3048005215442737,,Uncertain,,Uncertain,,0.15827570094936844,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.271,1.4703,-22.239,-6.43911129997014,0.7937256395179739,Pathogenic,0.9727,pathogenic,-4.267,available,https://doi.org/10.1101/2022.10.22.513328 +I255D,NP_000537:p.Ile255Asp,,,,,saturation_mutlist,,,,,,,,3.71121,3.9508646583557128,,4.745267309142094,,4.228238654571047,,Destabilizing,Destabilizing,,Destabilizing,0.3250522869735485,,0.21341580849975703,2.83277,,3.896687666421277,,3.3647288332106386,,Uncertain,,Destabilizing,,0.32420625357649385,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.4151,1.4703,-22.239,-6.43911129997014,0.844646006177901,Pathogenic,0.9998,pathogenic,-4.742,available,https://doi.org/10.1101/2022.10.22.513328 +I255E,NP_000537:p.Ile255Glu,,,,,saturation_mutlist,,,,,,,,2.95394,3.5258291721343995,,4.288942662756015,,3.6214413313780076,,Uncertain,Destabilizing,,Destabilizing,0.3011630076349422,,0.15807642475266293,3.2018,,3.323604096952524,,3.262702048476262,,Destabilizing,,Destabilizing,,0.39812375557442903,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.396,1.4703,-22.239,-6.43911129997014,0.8060967361543939,Pathogenic,0.9992,pathogenic,-4.748,available,https://doi.org/10.1101/2022.10.22.513328 +I255F,NP_000537:p.Ile255Phe,"hg19,17:g.7577518T>A, hg19,17:g.7674200T>A, hg38,17:g.7674200T>A",,,0.785,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376621,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,3.79319,1.0973029947280883,1.43084,1.0979049706058275,2.612015,2.4455474853029138,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.3915879954585591,0.6588838250152045,0.3905927041441161,3.23529,2.1578233333333334,0.5555767832609845,2.696556666666667,1.8954333916304922,Uncertain,Uncertain,Uncertain,Neutral,1.6144143891069467,1.3180681402696062,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,neutral,,-0.252,1.4703,-22.239,-3.51894571455168,0.2299504849217117,Benign,0.7283,pathogenic,-3.581,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I255G,NP_000537:p.Ile255Gly,,,,,saturation_mutlist,,,,,,,,5.9021,3.6117014694213867,,5.753635137013529,,5.827867568506765,,Destabilizing,Destabilizing,,Destabilizing,0.30804346952864314,,0.20752299226677287,3.73825,,4.797559283234249,,4.2679046416171245,,Destabilizing,,Destabilizing,,0.3003931295738543,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.3817,1.4703,-22.239,-6.43911129997014,0.8599231051566617,Pathogenic,0.9982,pathogenic,-4.575,available,https://doi.org/10.1101/2022.10.22.513328 +I255H,NP_000537:p.Ile255His,,,,,saturation_mutlist,,,,,,,,4.37979,2.680671215057373,,2.724829182083983,,3.5523095910419915,,Uncertain,Destabilizing,,Destabilizing,0.2915144081294269,,0.20177484370570734,4.31893,,2.04076473507069,,3.179847367535345,,Uncertain,,Destabilizing,,0.8070809818391181,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.3816,1.4703,-22.239,-4.62349728709182,0.826189305818647,Pathogenic,0.9982,pathogenic,-4.588,available,https://doi.org/10.1101/2022.10.22.513328 +I255K,NP_000537:p.Ile255Lys,,,,,saturation_mutlist,,,,,,,,3.88869,2.9569029712677004,,5.119386085679097,,4.504038042839548,,Destabilizing,Destabilizing,,Destabilizing,0.29895811983229026,,0.3240400012312993,4.51726,,3.848529402794616,,4.182894701397308,,Destabilizing,,Destabilizing,,0.42999314548131073,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.3885,1.4703,-22.239,-6.43911129997014,0.8458772989612148,Pathogenic,0.9986,pathogenic,-4.695,available,https://doi.org/10.1101/2022.10.22.513328 +I255L,NP_000537:p.Ile255Leu,,,,,saturation_mutlist,,,,,,,,0.28441,0.9780024862289429,,0.8703025348513461,,0.577356267425673,,Neutral,Neutral,,Neutral,0.17025044468113376,,0.05322826493510425,-0.1563,,0.6506004606915584,,0.2471502303457792,,Neutral,,Neutral,,0.4195124989189338,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.0793,1.4703,-3.2508,-1.69880606760401,9.473667499229652e-06,Benign,0.2937,benign,-3.242,available,https://doi.org/10.1101/2022.10.22.513328 +I255M,NP_000537:p.Ile255Met,"hg38,17:g.7674198G>C",,,0.791,"COSMIC,saturation_mutlist",,,,,,,,0.08174,1.40884211063385,1.1649666666666667,1.7241010218249018,0.6233533333333333,0.9029205109124508,Neutral,Neutral,Uncertain,Neutral,Neutral,0.1821478575399154,0.13903994398093739,0.009687783261138214,0.23169,-0.5036266666666667,1.2978820592268494,-0.13596833333333333,0.7647860296134247,Neutral,Neutral,Neutral,Neutral,2.464699884912743,0.5098602267628236,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.0997,1.4703,-6.1439,-1.79668142913908,0.0022981783374836,Benign,0.4549,ambiguous,-3.556,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I255N,NP_000537:p.Ile255Asn,"hg19,17:g.7577517A>T, hg19,17:g.7674199A>T, hg38,17:g.7674199A>T",,,0.928,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",232289,Conflicting classifications of pathogenicity,1,,,,,3.31071,3.4483507251739502,3.7442166666666665,3.3386488059860873,3.5274633333333334,3.3246794029930435,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.29911334570415016,0.188380807467805,0.05713615639887494,2.286,3.2682533333333335,2.909315094302942,2.7771266666666667,2.597657547151471,Uncertain,Uncertain,Uncertain,Uncertain,0.8437909823857775,0.214938207447839,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.3281,1.4703,-22.239,-6.43911129997014,0.8221242480018573,Pathogenic,0.9967,pathogenic,-4.556,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I255P,NP_000537:p.Ile255Pro,,,,,saturation_mutlist,,,,,,,,6.0473,3.451539144515991,,7.20067582045579,,6.6239879102278945,,Destabilizing,Destabilizing,,Destabilizing,0.24606071374759148,,0.7073013364549721,3.17648,,6.016115360101748,,4.596297680050874,,Destabilizing,,Destabilizing,,0.5528287201194703,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.4351,1.4703,-22.239,-6.43911129997014,0.7576963461620445,Pathogenic,0.9988,pathogenic,-4.62,available,https://doi.org/10.1101/2022.10.22.513328 +I255Q,NP_000537:p.Ile255Gln,,,,,saturation_mutlist,,,,,,,,2.73384,3.0287534618377685,,3.2646615496227205,,2.99925077481136,,Uncertain,Destabilizing,,Uncertain,0.2918624249148097,,0.08911194869728992,2.86613,,2.6156035932393715,,2.740866796619686,,Uncertain,,Uncertain,,0.4020519475716591,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.3557,1.4703,-22.239,-6.43911129997014,0.7913340875249034,Pathogenic,0.9979,pathogenic,-4.591,available,https://doi.org/10.1101/2022.10.22.513328 +I255R,NP_000537:p.Ile255Arg,,,,,saturation_mutlist,,,,,,,,6.41215,2.933401737213135,,4.089952683493592,,5.251051341746796,,Destabilizing,Destabilizing,,Destabilizing,0.2950439538274424,,0.3866306822810549,7.63901,,2.926147416897829,,5.282578708448915,,Uncertain,,Destabilizing,,0.6399274878152548,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,neutral,,-0.4153,1.4703,-22.239,-6.43911129997014,0.8526216881455042,Pathogenic,0.9972,pathogenic,-4.732,available,https://doi.org/10.1101/2022.10.22.513328 +I255S,NP_000537:p.Ile255Ser,"hg19,17:g.7577517A>C, hg19,17:g.7674199A>C, hg38,17:g.7674199A>C",,,0.943,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376622,Uncertain significance,1,Likely oncogenic,1,,,5.08959,3.119682579040527,4.395576666666667,4.576917522636969,4.742583333333334,4.833253761318485,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.27048990148381047,0.2061703480673741,0.15574710438927278,2.86731,4.257596666666666,3.6353316671026072,3.562453333333333,3.2513208335513033,Uncertain,Uncertain,Destabilizing,Destabilizing,0.7066084910487717,0.20010487949963046,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.3316,1.4703,-22.239,-6.43911129997014,0.8478463975584712,Pathogenic,0.9923,pathogenic,-4.501,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I255T,NP_000537:p.Ile255Thr,"hg19,17:g.7577516_7577517delinsAG, hg19,17:g.7577517A>G, hg19,17:g.7674199A>G, hg38,17:g.7674198_7674199delinsAG, hg38,17:g.7674199A>G",,,0.948,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376623,Uncertain significance,1,,,,,3.48782,2.539035177230835,2.8983000000000003,3.179132176820874,3.19306,3.3334760884104373,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.2089491957822299,0.13762994538495857,0.09592704786276043,1.45374,2.7784599999999995,2.5557301148400358,2.1161,2.004735057420018,Uncertain,Uncertain,Uncertain,Uncertain,0.1080092258405117,0.04547562550059832,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.2484,1.4703,-22.239,-6.43911129997014,0.8272273603648213,Pathogenic,0.9812,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I255V,NP_000537:p.Ile255Val,"hg19,17:g.7577518T>C, hg38,17:g.7674200T>C",,,0.628,"COSMIC,ClinVar,saturation_mutlist",3242231,,,,,Tier IV - Benign/Likely benign,0,1.28722,0.7460276556015014,0.9391166666666666,1.2076059120361373,1.1131683333333333,1.2474129560180687,Neutral,Neutral,Neutral,Neutral,Neutral,0.15753971545802217,0.14022012559622898,0.06511075697295006,0.18291,0.9069166666666667,1.0630322519287232,0.5449133333333334,0.6229711259643615,Neutral,Neutral,Neutral,Neutral,0.31781241745546834,0.1320128779506317,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,uncertain,,-0.029,1.4703,-1.2098,-1.75416370524352,3.188483186119049e-05,Benign,0.1835,benign,-3.184,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I255W,NP_000537:p.Ile255Trp,,,,,saturation_mutlist,,,,,,,,10.00667,1.296746826171875,,2.266874289610437,,6.136772144805218,,Uncertain,Uncertain,,Destabilizing,0.46681660451014045,,0.49535893229342826,10.11224,,0.8900857436813848,,5.501162871840692,,Uncertain,,Destabilizing,,1.4399102326111248,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,neutral,,-0.3409,1.4703,-22.239,-4.05758481142232,0.0862977783209384,Benign,0.9957,pathogenic,-4.376,available,https://doi.org/10.1101/2022.10.22.513328 +I255Y,NP_000537:p.Ile255Tyr,,,,,saturation_mutlist,,,,,,,,5.61787,1.3762303400039673,,2.010757539964064,,3.814313769982032,,Uncertain,Uncertain,,Destabilizing,0.4111753856155302,,0.5515772241276168,6.18528,,1.038084502753627,,3.611682251376813,,Uncertain,,Destabilizing,,1.4217536987090524,0.022,0.098,3.895,3.313,,True,0.022,,neutral,neutral,neutral,,True,3.895,,neutral,neutral,neutral,neutral,,-0.3497,1.4703,-22.239,-4.62349728709182,0.460097822430985,Uncertain,0.9883,pathogenic,-4.387,available,https://doi.org/10.1101/2022.10.22.513328 +T256A,NP_000537:p.Thr256Ala,"hg19,17:g.7577515T>C, hg38,17:g.7674197T>C",,,0.909,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141011,Uncertain significance,2,,,,,1.19886,0.6004454350471496,0.44932,0.4092364030393954,0.82409,0.8040482015196977,Neutral,Neutral,Neutral,Neutral,Neutral,0.21326468722601788,0.2954747211973753,0.11439625105632746,0.37427,0.09931999999999998,0.6658063898683632,0.23679499999999998,0.5200381949341816,Neutral,Neutral,Neutral,Neutral,0.1064064296302938,0.5725296836750066,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.3146,0.0888,-22.239,-4.85637614669093,0.8649737807577336,Pathogenic,0.8745,pathogenic,-4.116,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T256C,NP_000537:p.Thr256Cys,,,,,saturation_mutlist,,,,,,,,0.72407,-0.10823202848434446,,0.8497311677064033,,0.7869005838532017,,Neutral,Neutral,,Neutral,0.21789944424659113,,0.1485249480804533,-0.01288,,0.8104670004399734,,0.3987935002199867,,Neutral,,Neutral,,0.5859265643268983,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.3504,0.0888,-22.239,-3.49866155747281,0.8188868470317971,Pathogenic,0.9437,pathogenic,-4.254,available,https://doi.org/10.1101/2022.10.22.513328 +T256D,NP_000537:p.Thr256Asp,,,,,saturation_mutlist,,,,,,,,1.94502,1.3573203706741332,,1.1272992092787761,,1.536159604639388,,Neutral,Uncertain,,Neutral,0.16294834989519275,,0.1919701445920797,1.66165,,1.1597379902042086,,1.4106939951021045,,Neutral,,Neutral,,0.5759750361531537,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,uncertain,,-0.4302,0.0888,-22.239,-6.91649716536948,0.8575983207042241,Pathogenic,0.9924,pathogenic,-4.768,available,https://doi.org/10.1101/2022.10.22.513328 +T256E,NP_000537:p.Thr256Glu,,,,,saturation_mutlist,,,,,,,,1.39951,0.3915032732486725,,0.46805230820025273,,0.9337811541001264,,Neutral,Neutral,,Neutral,0.25035637546273143,,0.23780838770981666,0.71383,,0.8347805182055773,,0.7743052591027886,,Neutral,,Neutral,,0.5517426882939747,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.4055,0.0888,-22.239,-6.91649716536948,0.6903681600919974,Pathogenic,0.9909,pathogenic,-4.539,available,https://doi.org/10.1101/2022.10.22.513328 +T256F,NP_000537:p.Thr256Phe,,,,,saturation_mutlist,,,,,,,,3.75532,0.2687499904632568,,-0.7296193526974742,,1.512850323651263,,Uncertain,Neutral,,Neutral,0.25551365361817263,,0.22986174941640108,3.35989,,-0.5597198718283817,,1.4000850640858091,,Uncertain,,Neutral,,0.4767815293749006,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.4219,0.0888,-22.239,-8.08902677723851,0.8189513046682451,Pathogenic,0.9834,pathogenic,-4.502,available,https://doi.org/10.1101/2022.10.22.513328 +T256G,NP_000537:p.Thr256Gly,,,,,saturation_mutlist,,,,,,,,2.68508,1.8867148685455322,,1.972300001880761,,2.3286900009403806,,Uncertain,Uncertain,,Uncertain,0.21009094700062483,,0.07387888377618385,1.41088,,2.0732863149106544,,1.742083157455327,,Uncertain,,Neutral,,0.4534340309330634,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.3881,0.0888,-22.239,-8.08902677723851,0.8708643519453154,Pathogenic,0.9349,pathogenic,-4.514,available,https://doi.org/10.1101/2022.10.22.513328 +T256H,NP_000537:p.Thr256His,,,,,saturation_mutlist,,,,,,,,4.65829,0.7872091734409332,,0.022210983692082725,,2.3402504918460414,,Uncertain,Neutral,,Uncertain,0.2462098813916051,,0.18647632067224168,3.88962,,0.13472637873482407,,2.012173189367412,,Uncertain,,Uncertain,,0.5181387221479491,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.4022,0.0888,-22.239,-8.08902677723851,0.8572835831300849,Pathogenic,0.9534,pathogenic,-4.574,available,https://doi.org/10.1101/2022.10.22.513328 +T256I,NP_000537:p.Thr256Ile,"hg19,17:g.7577514G>A, hg19,17:g.7674196G>A, hg38,17:g.7674196G>A",,,0.932,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",858889,Uncertain significance,2,,,,,-1.10617,-0.7136178255081177,-1.10839,-1.011424830585238,-1.10728,-1.0587974152926192,Neutral,Neutral,Neutral,Neutral,Neutral,0.3024575744797923,0.6367302916201385,0.4937542962819519,-1.31264,-1.6581633333333332,-0.8857045559757187,-1.4854016666666667,-1.0991722779878594,Neutral,Neutral,Neutral,Neutral,0.5987538745502102,0.5002316069108962,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.3405,0.0888,-22.239,-6.440376219923,0.2848579304509337,Benign,0.975,pathogenic,-3.965,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T256K,NP_000537:p.Thr256Lys,"hg19,17:g.7577514G>T, hg38,17:g.7674196G>T",,,0.936,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2826159,Uncertain significance,1,,,,,1.05831,0.9969446063041687,1.4153066666666667,0.2566913532646262,1.2368083333333333,0.6575006766323132,Neutral,Neutral,Neutral,Neutral,Neutral,0.370722293840604,0.1088587746680176,0.028722929553961316,1.06459,1.3908133333333332,0.6807657245325475,1.2277016666666665,0.8726778622662736,Neutral,Neutral,Neutral,Neutral,0.41980501325681613,0.4748871135646693,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.3977,0.0888,-22.239,-7.81772897076735,0.8396729730775638,Pathogenic,0.9946,pathogenic,-4.526,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T256L,NP_000537:p.Thr256Leu,,,,,saturation_mutlist,,,,,,,,-0.42339,-0.25236499309539795,,-0.872996729585128,,-0.648193364792564,,Neutral,Neutral,,Neutral,0.30911882458764234,,0.369770842213002,-1.75241,,-0.9412587123493793,,-1.3468343561746896,,Neutral,,Neutral,,0.3206173121610206,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.3925,0.0888,-22.239,-6.39053795770667,0.6214769584916905,Uncertain,0.8612,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328 +T256M,NP_000537:p.Thr256Met,,,,,saturation_mutlist,,,,,,,,-0.7249,-0.1370748233795166,,-0.32195679476159406,,-0.523428397380797,,Neutral,Neutral,,Neutral,0.3223391183975193,,0.26900784414691037,-1.9008,,-0.33849052310693906,,-1.1196452615534696,,Neutral,,Neutral,,0.35402998751056886,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.3594,0.0888,-22.239,-6.98010707437491,0.7294850422104464,Pathogenic,0.7838,pathogenic,-4.153,available,https://doi.org/10.1101/2022.10.22.513328 +T256N,NP_000537:p.Thr256Asn,,,,,saturation_mutlist,,,,,,,,1.36052,1.272662467956543,,0.5479879076604753,,0.9542539538302377,,Neutral,Uncertain,,Neutral,0.23097725572388442,,0.11081026045891106,1.24393,,0.5845063918549317,,0.9142181959274658,,Neutral,,Neutral,,0.5487854619358261,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,uncertain,,-0.3702,0.0888,-22.239,-5.89880588250078,0.5974895569380456,Uncertain,0.8675,pathogenic,-4.02,available,https://doi.org/10.1101/2022.10.22.513328 +T256P,NP_000537:p.Thr256Pro,"hg19,17:g.7577515T>G, hg19,17:g.7674197T>G, hg38,17:g.7674197T>G",,,0.945,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528269,Conflicting classifications of pathogenicity,1,,,,,4.05698,2.679326543807983,2.7460299999999997,3.0955071351833996,3.4015050000000002,3.5762435675916997,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.32866694260147494,0.34128724001931277,0.07903877003634899,4.16287,2.2941033333333336,3.8194142592011797,3.228486666666667,3.99114212960059,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.7018982436380805,0.9698148672621646,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,uncertain,,-0.4111,0.0888,-8.9511,-8.08902677723851,0.5663531514186722,Uncertain,0.9887,pathogenic,-4.363,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T256Q,NP_000537:p.Thr256Gln,,,,,saturation_mutlist,,,,,,,,0.47201,0.4609614658355713,,0.4187974811505201,,0.44540374057526005,,Neutral,Neutral,,Neutral,0.2620444676855894,,0.20210755921225676,0.40395,,0.40111789509752466,,0.4025339475487623,,Neutral,,Neutral,,0.44434555879781157,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.3797,0.0888,-22.239,-5.73987309400099,0.4649424015587644,Uncertain,0.9678,pathogenic,-4.281,available,https://doi.org/10.1101/2022.10.22.513328 +T256R,NP_000537:p.Thr256Arg,"hg19,17:g.7577514G>C, hg38,17:g.7674196G>C",,,0.935,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.74158,0.8319617891311646,0.8446700000000001,-0.26583109858574033,1.293125,0.7378744507071298,Neutral,Neutral,Neutral,Neutral,Neutral,0.37278955744589787,0.16680914383410358,0.03375122459858758,1.68145,0.9269833333333333,0.05993860075609936,1.3042166666666666,0.8706943003780496,Neutral,Neutral,Neutral,Neutral,0.41687650044374325,0.5374741039855991,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.4006,0.0888,-22.239,-7.67905902354375,0.6420822362092966,Uncertain,0.9902,pathogenic,-4.345,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T256S,NP_000537:p.Thr256Ser,"hg38,17:g.7674197T>A",,,0.846,"COSMIC,saturation_mutlist",,,,,,,,1.21649,0.679718132019043,1.0284566666666668,1.0426686742541602,1.1224733333333334,1.1295793371270801,Neutral,Neutral,Neutral,Neutral,Neutral,0.13061668820816355,0.16302674981595977,0.15484881525512686,0.84805,0.6882066666666667,1.1001812339754882,0.7681283333333333,0.9741156169877441,Neutral,Neutral,Neutral,Neutral,0.2208509063196758,0.6555851999683517,8.391,5.534,5.31,5.755,,True,8.391,,neutral,,,,True,5.31,,neutral,,,neutral,,-0.2003,0.0888,-6.9513,-2.22859017085069,0.009839484787646,Benign,0.4732,ambiguous,-3.532,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T256V,NP_000537:p.Thr256Val,,,,,saturation_mutlist,,,,,,,,-0.77993,-0.7835988759994507,,-0.8583857516505886,,-0.8191578758252943,,Neutral,Neutral,,Neutral,0.29493068724121385,,0.4282731470357698,-1.08914,,-0.6641602295849065,,-0.8766501147924532,,Neutral,,Neutral,,0.6844002527436531,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.3281,0.0888,-22.239,-6.98010707437491,0.869833277481687,Pathogenic,0.94,pathogenic,-4.312,available,https://doi.org/10.1101/2022.10.22.513328 +T256W,NP_000537:p.Thr256Trp,,,,,saturation_mutlist,,,,,,,,4.27856,-0.07570088148117066,,-0.9193977007557659,,1.679581149622117,,Uncertain,Neutral,,Neutral,0.15460508414583865,,0.2386525788130174,5.18713,,-0.5435556417295512,,2.3217871791352245,,Uncertain,,Uncertain,,0.5756107854846566,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.4148,0.0888,-22.239,-8.08902677723851,0.8613228723652996,Pathogenic,0.9941,pathogenic,-4.73,available,https://doi.org/10.1101/2022.10.22.513328 +T256Y,NP_000537:p.Thr256Tyr,,,,,saturation_mutlist,,,,,,,,6.06768,0.12616125106811524,,-0.479735868664488,,2.7939720656677562,,Uncertain,Neutral,,Uncertain,0.2875133732272084,,0.2029737638380949,5.91506,,-0.25189875976499637,,2.831580620117502,,Uncertain,,Uncertain,,0.4944983504461041,8.391,5.534,5.31,5.755,,True,8.391,,uncertain,,,,True,5.31,,uncertain,,,neutral,,-0.4233,0.0888,-22.239,-8.08902677723851,0.842929572212407,Pathogenic,0.9834,pathogenic,-4.554,available,https://doi.org/10.1101/2022.10.22.513328 +L257A,NP_000537:p.Leu257Ala,,,,,saturation_mutlist,,,,,,,,4.49577,2.8812382888793944,,3.9308394428017444,,4.213304721400872,,Destabilizing,Destabilizing,,Destabilizing,0.21707429368363798,,0.1271980041784057,1.45574,,2.7500583816191746,,2.1028991908095875,,Uncertain,,Uncertain,,0.5554372272211866,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.4106,0.0969,-22.239,-7.70269970020109,0.8035756844176039,Pathogenic,0.9721,pathogenic,-4.526,available,https://doi.org/10.1101/2022.10.22.513328 +L257C,NP_000537:p.Leu257Cys,,,,,saturation_mutlist,,,,,,,,3.56211,1.8229261970520019,,3.9826194379108784,,3.7723647189554392,,Destabilizing,Uncertain,,Destabilizing,0.18798174833852152,,0.1544545522723909,0.88414,,2.8892278854484825,,1.8866839427242412,,Uncertain,,Neutral,,0.6297430937103836,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.3998,0.0969,-22.239,-7.70269970020109,0.8707925809280603,Pathogenic,0.9737,pathogenic,-4.412,available,https://doi.org/10.1101/2022.10.22.513328 +L257D,NP_000537:p.Leu257Asp,,,,,saturation_mutlist,,,,,,,,4.79439,3.7913101291656495,,5.208724988251998,,5.001557494125999,,Destabilizing,Destabilizing,,Destabilizing,0.39435869222225145,,0.12345437959901379,2.81078,,4.008206480998614,,3.409493240499307,,Uncertain,,Destabilizing,,0.25426446352528864,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.5321,0.0969,-22.239,-8.13493771905467,0.8653884843729469,Pathogenic,0.9999,pathogenic,-4.886,available,https://doi.org/10.1101/2022.10.22.513328 +L257E,NP_000537:p.Leu257Glu,,,,,saturation_mutlist,,,,,,,,4.09227,3.4867885971069335,,4.643318947696735,,4.367794473848368,,Destabilizing,Destabilizing,,Destabilizing,0.287477356824808,,0.14908335262125236,3.00632,,3.853535506418489,,3.4299277532092445,,Destabilizing,,Destabilizing,,0.29202275649285503,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.5002,0.0969,-22.239,-8.13493771905467,0.8700700904934778,Pathogenic,0.9984,pathogenic,-4.777,available,https://doi.org/10.1101/2022.10.22.513328 +L257F,NP_000537:p.Leu257Phe,,,,,saturation_mutlist,,,,,,,,2.19386,1.5149331521987914,,1.8292024580906034,,2.0115312290453016,,Uncertain,Uncertain,,Uncertain,0.41953332991745335,,0.04678044207587627,6.26215,,1.5608151934700227,,3.9114825967350115,,Uncertain,,Destabilizing,,0.7828392082119823,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.344,0.0969,-22.239,-8.13493771905467,0.7893772274689376,Pathogenic,0.9477,pathogenic,-4.259,available,https://doi.org/10.1101/2022.10.22.513328 +L257G,NP_000537:p.Leu257Gly,,,,,saturation_mutlist,,,,,,,,6.15167,3.6085014820098875,,6.191489967937667,,6.171579983968833,,Destabilizing,Destabilizing,,Destabilizing,0.22007462197080435,,0.13939927568039828,1.60339,,4.47448261349734,,3.03893630674867,,Uncertain,,Destabilizing,,0.22223600362710716,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.4854,0.0969,-22.239,-8.13493771905467,0.8692530621620168,Pathogenic,0.9972,pathogenic,-4.77,available,https://doi.org/10.1101/2022.10.22.513328 +L257H,NP_000537:p.Leu257His,,,,,saturation_mutlist,,,,,,,,3.93447,3.420594425201416,,3.3944697192920614,,3.664469859646031,,Destabilizing,Destabilizing,,Destabilizing,0.3061332759934089,,0.044228157700155514,6.03903,,2.585398137942354,,4.312214068971177,,Uncertain,,Destabilizing,,0.502920597835607,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.453,0.0969,-22.239,-8.13493771905467,0.858509608348218,Pathogenic,0.9985,pathogenic,-4.604,available,https://doi.org/10.1101/2022.10.22.513328 +L257I,NP_000537:p.Leu257Ile,,,,,saturation_mutlist,,,,,,,,2.42552,1.1130066013336182,,1.6180880914782094,,2.021804045739105,,Uncertain,Uncertain,,Uncertain,0.3863595252312964,,0.22308172891394323,0.84057,,1.4973534338439822,,1.168961716921991,,Neutral,,Neutral,,0.8395119978533988,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,uncertain,,-0.2847,0.0969,-22.239,-2.74715223047285,0.8376628116379503,Pathogenic,0.6331,pathogenic,-4.228,available,https://doi.org/10.1101/2022.10.22.513328 +L257K,NP_000537:p.Leu257Lys,,,,,saturation_mutlist,,,,,,,,3.70425,3.6018110847473146,,5.999440911955354,,4.851845455977677,,Destabilizing,Destabilizing,,Destabilizing,0.3063347666640242,,0.400254299226283,3.78515,,4.551405248625923,,4.168277624312962,,Destabilizing,,Destabilizing,,0.6178692532322423,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,uncertain,,-0.4992,0.0969,-22.239,-8.13493771905467,0.8474843110450943,Pathogenic,0.9972,pathogenic,-4.775,available,https://doi.org/10.1101/2022.10.22.513328 +L257M,NP_000537:p.Leu257Met,"hg19,17:g.7577512G>T",,,0.843,"cBioPortal,saturation_mutlist",,,,,,,,-0.06886,1.1066936016082765,,1.8708867538448235,,0.9010133769224118,,Neutral,Uncertain,,Neutral,0.21873251621518397,,0.053360895742761955,-0.12691,,1.6735206873948825,,0.7733053436974412,,Neutral,,Neutral,,0.6237641965611358,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,uncertain,,-0.2402,0.0969,-8.9511,-2.2601558430761,0.0695531424165593,Benign,0.4883,ambiguous,-3.664,available,https://doi.org/10.1101/2022.10.22.513328 +L257N,NP_000537:p.Leu257Asn,,,,,saturation_mutlist,,,,,,,,3.87753,3.597132472991943,,3.7439695539510414,,3.8107497769755208,,Destabilizing,Destabilizing,,Destabilizing,0.25044887178807873,,0.17576810682990612,1.28507,,2.6605394388823114,,1.9728047194411555,,Uncertain,,Neutral,,0.43861867805196886,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.4784,0.0969,-22.239,-8.13493771905467,0.8694364088569443,Pathogenic,0.9993,pathogenic,-4.709,available,https://doi.org/10.1101/2022.10.22.513328 +L257P,NP_000537:p.Leu257Pro,"hg19,17:g.7577510_7577511delinsAG, hg19,17:g.7577511A>G, hg19,17:g.7674193A>G, hg38,17:g.7674193A>G",,,0.933,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458562,Conflicting classifications of pathogenicity,1,,,,,6.51134,3.538832120895386,7.025393333333334,8.31929112827532,6.768366666666667,7.415315564137661,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.31827464641346276,0.9974822697282504,0.5156779704809166,2.56707,4.847733333333333,6.998398366460628,3.7074016666666667,4.782734183230314,Uncertain,Uncertain,Destabilizing,Destabilizing,1.8339858967348202,0.7188689342500442,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.494,0.0969,-22.239,-8.13493771905467,0.8699140235098215,Pathogenic,0.9993,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L257Q,NP_000537:p.Leu257Gln,"hg19,17:g.7577511A>T, hg19,17:g.7674193A>T, hg38,17:g.7674193A>T",,,0.916,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12372,Conflicting classifications of pathogenicity,1,,,,,3.20449,3.3869105911254884,2.4595233333333333,3.5222973076171598,2.8320066666666666,3.36339365380858,Uncertain,Destabilizing,Destabilizing,Uncertain,Destabilizing,0.2790523880760631,0.11481712338419836,0.12164676960909981,2.02775,2.2595266666666665,2.805298799710324,2.1436383333333335,2.416524399855162,Uncertain,Uncertain,Uncertain,Uncertain,1.0506412744710834,0.4344762759827968,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.4314,0.0969,-22.239,-8.13493771905467,0.8708566439614697,Pathogenic,0.9953,pathogenic,-4.524,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L257R,NP_000537:p.Leu257Arg,"hg19,17:g.7577511A>C, hg19,17:g.7674193A>C, hg38,17:g.7674193A>C",,,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142134,Conflicting classifications of pathogenicity,1,,,,,4.6192,3.631170253753662,5.674603333333334,4.95680932498461,5.1469016666666665,4.788004662492305,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.34157292162860975,0.8551998054775788,0.3423688777674469,6.62462,2.8833299999999995,3.5396895853898163,4.753975,5.082154792694908,Uncertain,Destabilizing,Destabilizing,Destabilizing,2.089846008728873,0.5830651268957148,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.4179,0.0969,-7.9512,-8.13493771905467,0.859800224331768,Pathogenic,0.9938,pathogenic,-4.676,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L257S,NP_000537:p.Leu257Ser,,,,,saturation_mutlist,,,,,,,,5.01401,3.4582360076904295,,4.989428979678361,,5.00171948983918,,Destabilizing,Destabilizing,,Destabilizing,0.29340328427020923,,0.09232727856853304,2.2675,,3.5846746191682892,,2.926087309584145,,Uncertain,,Uncertain,,0.3604909649379387,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.441,0.0969,-22.239,-7.70269970020109,0.8702107084719308,Pathogenic,0.998,pathogenic,-4.608,available,https://doi.org/10.1101/2022.10.22.513328 +L257T,NP_000537:p.Leu257Thr,,,,,saturation_mutlist,,,,,,,,3.7684,3.15386549949646,,3.831107686423841,,3.7997538432119207,,Destabilizing,Destabilizing,,Destabilizing,0.3199489006507271,,0.162058788611599,2.25922,,2.7339683266244363,,2.496594163312218,,Uncertain,,Uncertain,,0.6694830134750226,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.3408,0.0969,-7.9512,-5.51087021326529,0.7995310199328023,Pathogenic,0.9884,pathogenic,-4.226,available,https://doi.org/10.1101/2022.10.22.513328 +L257V,NP_000537:p.Leu257Val,"hg19,17:g.7577512G>C, hg19,17:g.7674194G>C, hg38,17:g.7674194G>C",,,0.896,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",827201,Conflicting classifications of pathogenicity,1,,,,,3.10095,1.585667691230774,2.32959,2.1484590353308834,2.7152700000000003,2.6247045176654415,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.3772223779113847,0.6201656101934924,0.21486511446920664,1.13398,2.3058966666666665,1.6641876723805389,1.7199383333333333,1.3990838361902695,Uncertain,Neutral,Neutral,Neutral,2.7766172824780075,1.0240706054631286,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.321,0.0969,-22.239,-4.88168786702626,0.8706195464171612,Pathogenic,0.6232,pathogenic,-4.144,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L257W,NP_000537:p.Leu257Trp,,,,,saturation_mutlist,,,,,,,,5.82823,2.2822978639602662,,3.589941460853209,,4.7090857304266045,,Destabilizing,Destabilizing,,Destabilizing,0.45419254504742834,,0.23529291986926687,13.21312,,2.431260015963599,,7.822190007981799,,Uncertain,,Destabilizing,,0.590719899834353,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.4432,0.0969,-22.239,-8.13493771905467,0.8666430998369268,Pathogenic,0.9956,pathogenic,-4.709,available,https://doi.org/10.1101/2022.10.22.513328 +L257Y,NP_000537:p.Leu257Tyr,,,,,saturation_mutlist,,,,,,,,4.87148,2.481926136016846,,3.263280530859163,,4.067380265429581,,Destabilizing,Destabilizing,,Destabilizing,0.41333408103346614,,0.0907463953764582,9.27934,,2.3352077317605326,,5.807273865880266,,Uncertain,,Destabilizing,,0.7242606822208895,0.455,0.521,1.235,1.758,,True,0.455,,neutral,neutral,neutral,,True,1.235,,neutral,neutral,neutral,neutral,,-0.4361,0.0969,-22.239,-8.13493771905467,0.8689679678762479,Pathogenic,0.9965,pathogenic,-4.656,available,https://doi.org/10.1101/2022.10.22.513328 +E258A,NP_000537:p.Glu258Ala,"hg19,17:g.7577508T>G, hg19,17:g.7674190T>G, hg38,17:g.7674190T>G",,,0.955,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458563,Uncertain significance,2,,,,,0.18208,0.7408770298957825,0.24886666666666665,0.7774986705031397,0.21547333333333332,0.47978933525156986,Neutral,Neutral,Neutral,Neutral,Neutral,0.6646092450397076,0.18873597649155877,0.3417918053990684,0.07111,0.7863933333333334,0.6807382480096281,0.4287516666666667,0.37592412400481406,Neutral,Neutral,Neutral,Neutral,0.2239361192145851,0.17468133046830728,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.3206,0.0001,-22.239,-7.58032490440679,0.8700270825934455,Pathogenic,0.9822,pathogenic,-4.518,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258C,NP_000537:p.Glu258Cys,,,,,saturation_mutlist,,,,,,,,0.0036,-0.04984014272689819,,1.2126657021773481,,0.6081328510886741,,Neutral,Neutral,,Neutral,0.442285767148885,,0.43350999014325886,-0.13361,,1.0956873206134279,,0.48103866030671394,,Neutral,,Neutral,,0.24832730127037175,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.39,0.0001,-22.239,-7.58032490440679,0.8466672674539686,Pathogenic,0.995,pathogenic,-4.585,available,https://doi.org/10.1101/2022.10.22.513328 +E258D,NP_000537:p.Glu258Asp,"hg19,17:g.7577507T>A, hg19,17:g.7577507T>G, hg19,17:g.7674189T>A, hg38,17:g.7674189T>A, hg38,17:g.7674189T>G",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1360091,Uncertain significance,2,,,,,1.50314,2.0918183851242067,1.7739233333333333,0.9668528612280735,1.6385316666666667,1.2349964306140366,Neutral,Neutral,Destabilizing,Neutral,Neutral,0.34029948092623086,0.5654179209713427,0.24079436115370936,0.92176,1.0988666666666667,0.8138487997530602,1.0103133333333334,0.8678043998765301,Neutral,Neutral,Neutral,Neutral,0.8602903856386066,0.2640613493234088,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.2864,0.0001,-22.239,-4.93330392418067,0.8383242794957786,Pathogenic,0.9944,pathogenic,-4.333,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258F,NP_000537:p.Glu258Phe,,,,,saturation_mutlist,,,,,,,,1.86436,0.4134545397758484,,-0.06802903984932347,,0.8981654800753383,,Neutral,Neutral,,Neutral,0.4235168087968171,,0.3409356085545104,0.57191,,-0.2677874447935076,,0.15206127760324623,,Neutral,,Neutral,,0.5506048920020707,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.3676,0.0001,-22.239,-8.22023741839059,0.8442742802342119,Pathogenic,0.9995,pathogenic,-4.763,available,https://doi.org/10.1101/2022.10.22.513328 +E258G,NP_000537:p.Glu258Gly,"hg19,17:g.7577508T>C, hg19,17:g.7674190T>C, hg38,17:g.7674190T>C",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406590,Conflicting classifications of pathogenicity,1,,,,,1.11743,1.7259489178657532,2.0387766666666667,2.1543225179506664,1.5781033333333334,1.6358762589753333,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.5926200333144008,0.5684359842194683,0.3253675251590593,0.86645,2.417456666666667,1.8176482571347818,1.6419533333333334,1.342049128567391,Uncertain,Neutral,Neutral,Neutral,0.28881455992076005,0.28356523519757887,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.3464,0.0001,-22.239,-8.22023741839059,0.8688495611048404,Pathogenic,0.9859,pathogenic,-4.548,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258H,NP_000537:p.Glu258His,,,,,saturation_mutlist,,,,,,,,2.2571,1.2098408246040344,,0.382012398720559,,1.3195561993602793,,Uncertain,Uncertain,,Neutral,0.2638071655552749,,0.34401358458203457,1.18326,,0.1381937346851473,,0.6607268673425737,,Neutral,,Neutral,,0.34805180206752695,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.3589,0.0001,-22.239,-8.22023741839059,0.8630845360891406,Pathogenic,0.9977,pathogenic,-4.506,available,https://doi.org/10.1101/2022.10.22.513328 +E258I,NP_000537:p.Glu258Ile,,,,,saturation_mutlist,,,,,,,,-0.92,0.10857784032821655,,-0.1251219488713288,,-0.5225609744356644,,Neutral,Neutral,,Neutral,0.5004885363050561,,0.23365041181529564,-0.64283,,-0.3642536773405798,,-0.5035418386702899,,Neutral,,Neutral,,0.35778972531685727,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.373,0.0001,-22.239,-8.22023741839059,0.8647194537912188,Pathogenic,0.9963,pathogenic,-4.63,available,https://doi.org/10.1101/2022.10.22.513328 +E258K,NP_000537:p.Glu258Lys,"hg19,17:g.7577509C>T, hg19,17:g.7577509_7577510delinsTT, hg19,17:g.7674191C>T, hg38,17:g.7674191C>T, hg38,17:g.7674191_7674192delinsTT",,,0.961,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","4082532, 12348","Likely pathogenic, Pathogenic/Likely pathogenic","1, 2",Oncogenic,1,,,-0.22104,1.483462085723877,0.75068,1.0266438547215435,0.26482,0.40280192736077175,Neutral,Neutral,Uncertain,Neutral,Neutral,0.41518206134386443,0.40721021802831353,0.13179715496857802,-0.2275,1.0469366666666666,0.6486646642001359,0.4097183333333333,0.21058233210006794,Neutral,Neutral,Neutral,Neutral,0.20374472922971262,0.2694106195433094,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.3426,0.0001,-22.239,-7.66904678040932,0.8699085265877404,Pathogenic,0.9918,pathogenic,-4.464,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258L,NP_000537:p.Glu258Leu,"hg38,17:g.7674190_7674191delinsAA",,,,"COSMIC,saturation_mutlist",,,,,,,,-1.16852,0.6689521694183349,-1.2494333333333334,-0.2542552747459716,-1.2089766666666666,-0.7113876373729858,Neutral,Neutral,Neutral,Neutral,Neutral,0.37403164782836995,0.5001074034867132,0.27568930295952426,-0.99457,-0.24750333333333333,-0.46278514655821684,-0.6210366666666667,-0.7286775732791084,Neutral,Neutral,Neutral,Neutral,0.11844985164851644,0.4007797177129071,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.3751,0.0001,-22.239,-8.22023741839059,0.8701277011232702,Pathogenic,0.9966,pathogenic,-4.556,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258M,NP_000537:p.Glu258Met,,,,,saturation_mutlist,,,,,,,,-1.32517,0.24169160604476927,,0.15912966009156693,,-0.5830201699542166,,Neutral,Neutral,,Neutral,0.3296816469934389,,0.3819273905300615,-0.97465,,-0.06791776574173275,,-0.5212838828708664,,Neutral,,Neutral,,0.3892407591098305,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.3239,0.0001,-22.239,-8.22023741839059,0.8615661797678273,Pathogenic,0.995,pathogenic,-4.63,available,https://doi.org/10.1101/2022.10.22.513328 +E258N,NP_000537:p.Glu258Asn,,,,,saturation_mutlist,,,,,,,,0.82306,1.9317291831970216,,0.8459362909813469,,0.8344981454906735,,Neutral,Uncertain,,Neutral,0.32687184748011683,,0.22314374505515144,0.49486,,0.6793727357041489,,0.5871163678520744,,Neutral,,Neutral,,0.3228691590880455,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.3468,0.0001,-22.239,-4.93330392418067,0.8477451946398606,Pathogenic,0.9989,pathogenic,-4.698,available,https://doi.org/10.1101/2022.10.22.513328 +E258P,NP_000537:p.Glu258Pro,,,,,saturation_mutlist,,,,,,,,4.17413,3.3304980564117432,,4.062976445592777,,4.118553222796388,,Destabilizing,Destabilizing,,Destabilizing,0.397447828341183,,0.4890191804280199,1.89412,,3.0505944275240906,,2.472357213762045,,Uncertain,,Uncertain,,0.6763534870047915,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.4776,0.0001,-22.239,-6.56542053406238,0.8112485469762636,Pathogenic,0.9997,pathogenic,-4.794,available,https://doi.org/10.1101/2022.10.22.513328 +E258Q,NP_000537:p.Glu258Gln,"hg19,17:g.7577509C>G, hg19,17:g.7674191C>G, hg38,17:g.7674191C>G",,,0.936,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.2311,0.4605497741699219,-0.17426333333333333,0.541616664444193,-0.20268166666666665,0.1552583322220965,Neutral,Neutral,Neutral,Neutral,Neutral,0.41357379236725095,0.2520339686541391,0.3020121218360242,-0.19324,-0.2466,0.416697767776583,-0.21992,0.11172888388829151,Neutral,Neutral,Neutral,Neutral,0.3044670991530393,0.20627724321118415,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.2932,0.0001,-22.239,-4.33439569529132,0.664038973726442,Uncertain,0.9505,pathogenic,-4.085,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258R,NP_000537:p.Glu258Arg,,,,,saturation_mutlist,,,,,,,,0.45805,1.4696580934524537,,0.6522474495142014,,0.5551487247571008,,Neutral,Uncertain,,Neutral,0.3998024988514115,,0.1978442295668543,-0.04214,,0.30928119222754274,,0.13357059611377137,,Neutral,,Neutral,,0.2636263415315006,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.4031,0.0001,-22.239,-7.33311676482505,0.4556924294295201,Uncertain,0.9905,pathogenic,-4.354,available,https://doi.org/10.1101/2022.10.22.513328 +E258S,NP_000537:p.Glu258Ser,,,,,saturation_mutlist,,,,,,,,0.51298,1.084168016910553,,1.2786886570373808,,0.8958343285186904,,Neutral,Uncertain,,Neutral,0.4473216987001139,,0.3731191213727627,0.12816,,1.0817634185595424,,0.6049617092797712,,Neutral,,Neutral,,0.34318768916889025,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.3341,0.0001,-22.239,-7.58032490440679,0.8661646181794377,Pathogenic,0.991,pathogenic,-4.639,available,https://doi.org/10.1101/2022.10.22.513328 +E258T,NP_000537:p.Glu258Thr,,,,,saturation_mutlist,,,,,,,,0.34804,0.6128920531272888,,0.7323590907282919,,0.5401995453641459,,Neutral,Neutral,,Neutral,0.47257754621694437,,0.26872562979032927,-0.31726,,0.6192872318492647,,0.15101361592463236,,Neutral,,Neutral,,0.2458483997716888,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.35,0.0001,-22.239,-5.85665866064952,0.8708637148309493,Pathogenic,0.9906,pathogenic,-4.519,available,https://doi.org/10.1101/2022.10.22.513328 +E258V,NP_000537:p.Glu258Val,"hg19,17:g.7577508T>A, hg38,17:g.7674190T>A",,,0.963,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2808296,Uncertain significance,1,,,,,-0.84239,-0.16615193843841553,-0.9404766666666665,-0.05167091582806536,-0.8914333333333333,-0.4470304579140327,Neutral,Neutral,Neutral,Neutral,Neutral,0.6414453483395702,0.3971099255314019,0.25493667662194436,-0.69169,0.01939,-0.1335459750117666,-0.33615,-0.4126179875058833,Neutral,Neutral,Neutral,Neutral,0.056632828524334426,0.2899663814517131,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,uncertain,,-0.3339,0.0001,-22.239,-8.22023741839059,0.8197832286795876,Pathogenic,0.9887,pathogenic,-4.478,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258W,NP_000537:p.Glu258Trp,,,,,saturation_mutlist,,,,,,,,3.10928,0.8648102116584778,,-0.22386557330697202,,1.442707213346514,,Uncertain,Neutral,,Neutral,0.5587820787230345,,0.32505810470565444,1.4449,,-0.627555916564127,,0.40867204171793653,,Neutral,,Neutral,,0.42298578361922684,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.3777,0.0001,-22.239,-8.22023741839059,0.8549879951400899,Pathogenic,0.9996,pathogenic,-4.838,available,https://doi.org/10.1101/2022.10.22.513328 +E258Y,NP_000537:p.Glu258Tyr,,,,,saturation_mutlist,,,,,,,,2.83214,0.6707648611068726,,0.15352168463806024,,1.49283084231903,,Uncertain,Neutral,,Neutral,0.5723698626923983,,0.3094169219671618,1.26715,,-0.14156905047440402,,0.562790474762798,,Neutral,,Neutral,,0.4454225227085878,10.9,5.843,28.855,9.567,,True,10.9,,neutral,neutral,neutral,,True,28.855,,neutral,neutral,neutral,neutral,,-0.3685,0.0001,-22.239,-8.22023741839059,0.8558720996328555,Pathogenic,0.9991,pathogenic,-4.764,available,https://doi.org/10.1101/2022.10.22.513328 +D259A,NP_000537:p.Asp259Ala,"hg19,17:g.7577505T>G, hg38,17:g.7674187T>G",,,0.691,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2671888,Pathogenic,0,,,,,1.25053,2.247561755180359,1.7840133333333332,1.017803047969612,1.5172716666666666,1.134166523984806,Neutral,Neutral,Destabilizing,Neutral,Neutral,0.32271038989117234,0.7272963555678127,0.6476972660806062,-1.5456,0.22879666666666673,0.4243488208877362,-0.6584016666666667,-0.560625589556132,Neutral,Neutral,Neutral,Neutral,0.5701548745345913,0.2762224069104246,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.1392,1.3643,-5.7784,-1.70989184504227,0.0022733266521254,Benign,0.8494,pathogenic,-3.599,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259C,NP_000537:p.Asp259Cys,,,,,saturation_mutlist,,,,,,,,1.51072,1.4248060369491578,,1.4114572055040302,,1.4610886027520151,,Neutral,Uncertain,,Neutral,0.25998454011410277,,0.541763426789485,-1.19035,,0.9233193967488372,,-0.1335153016255814,,Neutral,,Neutral,,0.07370144592652263,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,uncertain,,-0.2646,1.3643,-22.2361,-2.57012179162441,0.0955584467050807,Benign,0.9449,pathogenic,-3.959,available,https://doi.org/10.1101/2022.10.22.513328 +D259E,NP_000537:p.Asp259Glu,"hg19,17:g.7577504G>T, hg38,17:g.7674186G>T",,,0.564,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.09739,2.016759877204895,1.9166633333333334,1.028724064749978,1.5070266666666667,1.063057032374989,Neutral,Neutral,Destabilizing,Neutral,Neutral,0.30657602127934,0.42782727529797454,0.6119353122013831,-0.03497,0.45419666666666675,0.6359059405406597,0.20961333333333337,0.3004679702703299,Neutral,Neutral,Neutral,Neutral,0.5493260798064803,0.5089856802373777,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.1681,1.3643,-22.2361,-3.87769875406997,0.080933087715221,Benign,0.8705,pathogenic,-3.787,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259F,NP_000537:p.Asp259Phe,"hg19,17:g.7577505_7577506delinsAA",,,,"cBioPortal,saturation_mutlist",,,,,,,,1.15596,2.253138709068298,3.3701833333333333,0.5618073945036235,2.263071666666667,0.8588836972518118,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,0.3173118604990407,0.6066402758545536,0.2760639533930639,3.47774,3.6764166666666664,-0.1209806972700469,3.577078333333333,1.6783796513649765,Destabilizing,Uncertain,Destabilizing,Neutral,1.8251394537648042,0.2756260635772943,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.3233,1.3643,-22.2361,-4.92934531738054,0.3081588402702837,Benign,0.9834,pathogenic,-4.329,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259G,NP_000537:p.Asp259Gly,"hg19,17:g.7577505T>C, hg38,17:g.7674187T>C",,3.9774716009e-06,0.655,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",188349,Uncertain significance,2,,,,,1.55608,1.9235061502456665,2.6253966666666666,1.8003317079065646,2.0907383333333334,1.6782058539532823,Uncertain,Neutral,Uncertain,Uncertain,Neutral,0.32496981164042915,0.6517967010417351,0.7681947825320067,-1.25037,1.14184,1.629177503845332,-0.05426500000000001,0.189403751922666,Neutral,Neutral,Neutral,Neutral,0.4641061514352078,0.3251228115460328,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.1503,1.3643,-5.7784,-2.8331597668249,3.225835084072401e-05,Benign,0.6494,pathogenic,-3.505,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259H,NP_000537:p.Asp259His,"hg19,17:g.7577506C>G, hg19,17:g.7674188C>G, hg38,17:g.7674188C>G",,,0.714,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1349622,Uncertain significance,2,,,,,1.97619,2.2002189207077025,1.6531766666666667,0.6792643356153697,1.8146833333333334,1.3277271678076847,Neutral,Neutral,Destabilizing,Neutral,Neutral,0.27785622263435067,1.1951373350744627,0.5756803128878327,3.62988,2.2183699999999997,0.10068339368372636,2.924125,1.8652816968418633,Uncertain,Uncertain,Uncertain,Neutral,1.4545957948745303,0.339201828511799,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.2325,1.3643,-22.2361,-4.02744588332535,0.0144226157941884,Benign,0.9217,pathogenic,-3.83,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259I,NP_000537:p.Asp259Ile,"hg19,17:g.7577505_7577506delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,2.43589,2.79660774230957,2.9066899999999998,0.7399371565973021,2.67129,1.587913578298651,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,0.28780791734057265,0.7665621865184845,0.45277174939241,-0.30729,0.26281000000000004,-0.04088868074112769,-0.022239999999999982,-0.17408934037056384,Neutral,Neutral,Neutral,Neutral,0.8649925831281253,0.46634489416580704,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.3155,1.3643,-22.2361,-4.38224410620792,0.2702251996198974,Benign,0.9856,pathogenic,-4.22,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259K,NP_000537:p.Asp259Lys,,,,,saturation_mutlist,,,,,,,,0.72186,2.6462684535980223,,0.9429696650645747,,0.8324148325322873,,Neutral,Destabilizing,,Neutral,0.2596199868244537,,0.6939092786326648,-0.39998,,0.8786421685926875,,0.23933108429634375,,Neutral,,Neutral,,0.6279271368599045,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.2939,1.3643,-22.2361,-3.51300888565769,0.1169506431497978,Benign,0.9778,pathogenic,-3.866,available,https://doi.org/10.1101/2022.10.22.513328 +D259L,NP_000537:p.Asp259Leu,,,,,saturation_mutlist,,,,,,,,0.1663,2.4265169382095335,,0.33554231447321586,,0.2509211572366079,,Neutral,Destabilizing,,Neutral,0.31706587918057205,,0.46185290174801524,-1.31042,,-0.5134151708686446,,-0.9119175854343222,,Neutral,,Neutral,,0.5938060619813641,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.3092,1.3643,-22.2361,-3.66140819714008,0.047511114431095,Benign,0.9627,pathogenic,-3.978,available,https://doi.org/10.1101/2022.10.22.513328 +D259M,NP_000537:p.Asp259Met,,,,,saturation_mutlist,,,,,,,,0.14659,2.3024732208251955,,0.699789600720422,,0.423189800360211,,Neutral,Destabilizing,,Neutral,0.35180750079831236,,0.5013403138419885,-1.84903,,-0.09437625370195028,,-0.9717031268509752,,Neutral,,Neutral,,0.4190357436565723,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.1624,1.3643,-5.4889,-3.08077902066545,0.5127309581769595,Uncertain,0.982,pathogenic,-4.167,available,https://doi.org/10.1101/2022.10.22.513328 +D259N,NP_000537:p.Asp259Asn,"hg19,17:g.7577506C>T, hg19,17:g.7674188C>T, hg38,17:g.7674188C>T",,,0.532,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3634427,Uncertain significance,1,,,,,0.82278,0.9835302543640136,1.0896833333333333,0.6621462249502363,0.9562316666666666,0.7424631124751182,Neutral,Neutral,Neutral,Neutral,Neutral,0.18729637279191613,0.1396917779334998,0.7164134535416524,-0.46193,-0.07879666666666667,0.3642086561212672,-0.27036333333333334,-0.04886067193936641,Neutral,Neutral,Neutral,Neutral,0.5633535118279541,0.19852978149026954,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,uncertain,,-0.1169,1.3643,-7.9483,-2.38353149124325,0.008458380545714,Benign,0.3388,benign,-3.511,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259P,NP_000537:p.Asp259Pro,,,,,saturation_mutlist,,,,,,,,3.08957,3.6572012233734132,,4.238426650107047,,3.6639983250535235,,Destabilizing,Destabilizing,,Destabilizing,0.2023063950760759,,0.9687729376291613,-0.42573,,5.882751085031358,,2.728510542515679,,Uncertain,,Uncertain,,0.8536939819044598,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,uncertain,,-0.3601,1.3643,-22.2361,-6.06473125273993,0.6040564678547501,Uncertain,0.9924,pathogenic,-4.396,available,https://doi.org/10.1101/2022.10.22.513328 +D259Q,NP_000537:p.Asp259Gln,,,,,saturation_mutlist,,,,,,,,1.27521,2.224321503639221,,1.080961411999387,,1.1780857059996934,,Neutral,Destabilizing,,Neutral,0.341798560788754,,0.5985608635969444,-0.06514,,0.40984919307830925,,0.17235459653915464,,Neutral,,Neutral,,0.3446116358182091,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.2501,1.3643,-22.2361,-3.21529273583598,0.0828247212520412,Benign,0.9639,pathogenic,-3.971,available,https://doi.org/10.1101/2022.10.22.513328 +D259R,NP_000537:p.Asp259Arg,,,,,saturation_mutlist,,,,,,,,0.95895,2.5605159616470337,,0.6798588787708767,,0.8194044393854383,,Neutral,Destabilizing,,Neutral,0.26199204443816665,,0.6344932042991617,0.51518,,0.2650439155957691,,0.39011195779788455,,Neutral,,Neutral,,0.6462012839855279,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.3249,1.3643,-22.2361,-3.5682057157072,0.0366652059799088,Benign,0.9801,pathogenic,-3.926,available,https://doi.org/10.1101/2022.10.22.513328 +D259S,NP_000537:p.Asp259Ser,"hg38,17:g.7674187_7674188delinsCT",,,,"COSMIC,saturation_mutlist",,,,,,,,1.14179,1.281874523162842,1.22109,1.11943671363984,1.18144,1.1306133568199201,Neutral,Neutral,Uncertain,Neutral,Neutral,0.36833329946899585,0.0871999522171123,0.49888448746934944,-1.30899,0.25272333333333336,1.175942440721954,-0.5281333333333333,-0.066523779639023,Neutral,Neutral,Neutral,Neutral,0.29060003410567975,0.29503255791767685,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.1418,1.3643,-5.0415,-1.16439102148646,4.513714236519315e-07,Benign,0.5538,ambiguous,-3.324,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259T,NP_000537:p.Asp259Thr,,,,,saturation_mutlist,,,,,,,,2.47415,1.6731831979751588,,1.0208013379353913,,1.7474756689676956,,Uncertain,Uncertain,,Neutral,0.46148024861746845,,0.5492606550114473,-1.13481,,0.5496877050276118,,-0.29256114748619416,,Neutral,,Neutral,,0.4013219620653825,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,uncertain,,-0.1487,1.3643,-0.5137,-1.12290732943819,1.4991491788158542e-08,Benign,0.7583,pathogenic,-3.165,available,https://doi.org/10.1101/2022.10.22.513328 +D259V,NP_000537:p.Asp259Val,"hg19,17:g.7577505T>A, hg19,17:g.7674187T>A, hg38,17:g.7674186_7674187delinsAA, hg38,17:g.7674187T>A",,,0.742,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",485034,Conflicting classifications of pathogenicity,1,,,,,2.56378,2.839278221130371,2.807373333333333,0.7878613619342633,2.6855766666666665,1.6758206809671317,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,0.30756341462403947,0.7291938286598122,0.414362367498717,-0.653,0.056573333333333364,0.06339516564525527,-0.29821333333333333,-0.2948024171773724,Neutral,Neutral,Neutral,Neutral,0.7772669112273395,0.3977291996183883,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.2702,1.3643,-22.2361,-4.70426656490911,0.5979896659917047,Uncertain,0.9451,pathogenic,-4.176,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259W,NP_000537:p.Asp259Trp,,,,,saturation_mutlist,,,,,,,,1.94957,2.2350392150878906,,0.29377245012501013,,1.1216712250625052,,Neutral,Destabilizing,,Neutral,0.3186541353541052,,0.4392453041124528,6.39629,,-0.5257612329911148,,2.9352643835044425,,Uncertain,,Uncertain,,0.4941107710642352,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.3037,1.3643,-22.2361,-4.92934531738054,0.7404677960501027,Pathogenic,0.9962,pathogenic,-4.547,available,https://doi.org/10.1101/2022.10.22.513328 +D259Y,NP_000537:p.Asp259Tyr,"hg19,17:g.7577506C>A, hg19,17:g.7674188C>A, hg38,17:g.7674188C>A",,,0.737,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634680,Uncertain significance,1,,,,,1.3132,2.639635443687439,3.6425133333333335,0.6851245195762714,2.477856666666667,0.9991622597881357,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,0.3140977435506785,0.7310277945164297,0.30214439098224904,5.24361,3.025283333333333,0.02260920257503927,4.134446666666666,2.63310960128752,Destabilizing,Uncertain,Destabilizing,Uncertain,1.2423193181661827,0.3663083590827225,27.238,6.093,19.89,13.793,,True,27.238,,neutral,neutral,neutral,,True,19.89,,neutral,neutral,neutral,neutral,,-0.2003,1.3643,-8.9482,-2.53379256730248,0.0232235630979985,Benign,0.8837,pathogenic,-3.966,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S260A,NP_000537:p.Ser260Ala,"hg38,17:g.7674185A>C",,,0.599,"COSMIC,saturation_mutlist",,,,,,,,0.07135,0.03779599428176881,0.06383,-0.10487362472447824,0.06759,-0.01676181236223912,Neutral,Neutral,Neutral,Neutral,Neutral,0.08211170505516995,0.24339274612581752,0.1325488699065458,-0.17285,-0.3612233333333333,0.09258301650793037,-0.26703666666666664,-0.04013349174603482,Neutral,Neutral,Neutral,Neutral,0.4614771523657,0.16906772279639512,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.0117,2.008,-5.7813,-0.38674266409016,8.008240952324595e-08,Benign,0.0661,benign,-3.033,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S260C,NP_000537:p.Ser260Cys,"hg19,17:g.7577502G>C, hg38,17:g.7674184G>C",,,0.660,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.45139,0.05606097698211669,0.7911566666666666,0.43461488581554936,0.6212733333333333,0.4430024429077747,Neutral,Neutral,Neutral,Neutral,Neutral,0.15409949140328594,0.38045884090427207,0.1613844339483896,0.30156,0.39025,0.6764558806520652,0.345905,0.48900794032603256,Neutral,Neutral,Neutral,Neutral,0.5747463870264866,0.0904698384563717,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.1462,2.008,-22.239,-2.11362212266492,0.0082748220277151,Benign,0.0973,benign,-3.462,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S260D,NP_000537:p.Ser260Asp,,,,,saturation_mutlist,,,,,,,,0.34283,0.18817538261413574,,0.004423509999132061,,0.17362675499956604,,Neutral,Neutral,,Neutral,0.1958378964668296,,0.11907868387626981,0.00384,,0.03642487448720106,,0.02013243724360053,,Neutral,,Neutral,,0.1205157047284756,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.1944,2.008,-22.239,-3.07923079775833,0.058320831697469,Benign,0.2697,benign,-3.53,available,https://doi.org/10.1101/2022.10.22.513328 +S260E,NP_000537:p.Ser260Glu,,,,,saturation_mutlist,,,,,,,,0.04627,0.17160539388656615,,-0.12828317299563854,,-0.04100658649781927,,Neutral,Neutral,,Neutral,0.21524992414053584,,0.14929664489509492,0.0606,,0.0177101138776183,,0.03915505693880915,,Neutral,,Neutral,,0.22708795045098518,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.0998,2.008,-8.9511,-2.28614415024623,0.0146926751219765,Benign,0.3196,benign,-3.31,available,https://doi.org/10.1101/2022.10.22.513328 +S260F,NP_000537:p.Ser260Phe,"hg19,17:g.7577502G>A, hg38,17:g.7674184G>A",,,0.636,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2765819,Uncertain significance,1,,,,,0.0612,0.47088113784790037,0.5122466666666666,-0.45793886504498055,0.28672333333333333,-0.19836943252249029,Neutral,Neutral,Neutral,Neutral,Neutral,0.25214354054139165,0.229475863702966,0.1501313785762732,-0.00594,0.36247,-0.20246159126886099,0.178265,-0.1042007956344305,Neutral,Neutral,Neutral,Neutral,0.578391452968201,0.26020913486504776,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.106,2.008,-8.9511,-2.57687113446244,0.0641929303903014,Benign,0.1977,benign,-3.578,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S260G,NP_000537:p.Ser260Gly,,,,,saturation_mutlist,,,,,,,,0.24485,0.35636622190475464,,0.4938798989457365,,0.36936494947286824,,Neutral,Neutral,,Neutral,0.1113936932146205,,0.11030893581678783,-0.02641,,0.47064925820404574,,0.22211962910202288,,Neutral,,Neutral,,0.007482622393585885,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.0371,2.008,-8.9511,-2.65757151669382,0.0162860394943667,Benign,0.0897,benign,-3.262,available,https://doi.org/10.1101/2022.10.22.513328 +S260H,NP_000537:p.Ser260His,,,,,saturation_mutlist,,,,,,,,0.35546,0.29771754026412967,,-0.43766866354739514,,-0.04110433177369757,,Neutral,Neutral,,Neutral,0.20756759865355434,,0.10288367762806758,0.41059,,-0.20811836272677034,,0.10123581863661484,,Neutral,,Neutral,,0.1905298551834426,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.0889,2.008,-5.3663,-2.15963477321954,0.000212639580705,Benign,0.255,benign,-3.16,available,https://doi.org/10.1101/2022.10.22.513328 +S260I,NP_000537:p.Ser260Ile,,,,,saturation_mutlist,,,,,,,,0.36955,0.402129020690918,,-0.40774127126930443,,-0.01909563563465222,,Neutral,Neutral,,Neutral,0.337942574670718,,0.20132428849999293,0.4076,,-0.055922055764463276,,0.17583897211776836,,Neutral,,Neutral,,0.294983819140116,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.1769,2.008,-22.239,-3.93109958189597,0.1394672752785239,Benign,0.1924,benign,-3.644,available,https://doi.org/10.1101/2022.10.22.513328 +S260K,NP_000537:p.Ser260Lys,,,,,saturation_mutlist,,,,,,,,-0.21953,0.2779726576805115,,-0.3173516415633374,,-0.2684408207816687,,Neutral,Neutral,,Neutral,0.16880593641354827,,0.11203018443292267,-0.1522,,0.053493661436997575,,-0.049353169281501214,,Neutral,,Neutral,,0.18778365535474792,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.1012,2.008,-5.9513,-1.00594302893451,1.84044676979515e-08,Benign,0.515,ambiguous,-3.148,available,https://doi.org/10.1101/2022.10.22.513328 +S260L,NP_000537:p.Ser260Leu,,,,,saturation_mutlist,,,,,,,,-0.05696,0.37789895057678224,,-0.7240495100916376,,-0.39050475504581883,,Neutral,Neutral,,Neutral,0.315553865423362,,0.25569243573407335,-0.04923,,-0.4938660844007962,,-0.27154804220039813,,Neutral,,Neutral,,0.21244085221062925,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.0952,2.008,-6.9513,-2.3755868189941,0.0041115638678851,Benign,0.1155,benign,-3.22,available,https://doi.org/10.1101/2022.10.22.513328 +S260M,NP_000537:p.Ser260Met,,,,,saturation_mutlist,,,,,,,,-0.02371,0.37288666009902954,,-0.3619647596278845,,-0.19283737981394225,,Neutral,Neutral,,Neutral,0.23341927857311845,,0.14218789664399725,-0.17031,,-0.1391492833002613,,-0.15472964165013064,,Neutral,,Neutral,,0.18395634356117882,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.1442,2.008,-22.239,-4.21462642092151,0.1026279299939304,Benign,0.2123,benign,-3.45,available,https://doi.org/10.1101/2022.10.22.513328 +S260N,NP_000537:p.Ser260Asn,,,,,saturation_mutlist,,,,,,,,0.25014,0.20149795532226564,,-0.1733965399796903,,0.03837173001015484,,Neutral,Neutral,,Neutral,0.16930048255465652,,0.15614024117094644,0.16601,,-0.07113945786733224,,0.04743527106633388,,Neutral,,Neutral,,0.0019749652888226125,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.0421,2.008,-7.3663,-1.82677753753766,0.0003776364950087,Benign,0.1465,benign,-3.282,available,https://doi.org/10.1101/2022.10.22.513328 +S260P,NP_000537:p.Ser260Pro,"hg19,17:g.7577503A>G, hg38,17:g.7674185A>G",,,0.659,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.47415,0.7882659375667572,0.8192733333333333,3.504586589674236,0.17256166666666664,1.515218294837118,Neutral,Uncertain,Neutral,Neutral,Neutral,0.5335142016783627,0.8218208598526134,1.1034098054921229,1.18185,1.3251733333333333,2.5644161130795067,1.2535116666666668,1.8731330565397535,Neutral,Uncertain,Neutral,Neutral,1.6590016231121922,1.5691735903395687,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.1533,2.008,-3.4594,-0.672831220077273,1.2133532166864592e-06,Benign,0.0896,benign,-3.008,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S260Q,NP_000537:p.Ser260Gln,,,,,saturation_mutlist,,,,,,,,0.06284,0.24251387834548951,,-0.08277816985583628,,-0.009969084927918141,,Neutral,Neutral,,Neutral,0.181005763658026,,0.1012193925507563,0.0543,,0.1755546406373589,,0.11492732031867944,,Neutral,,Neutral,,0.16074530589092026,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.0456,2.008,-4.1964,-1.86364294399756,1.0124058415458133e-05,Benign,0.3127,benign,-3.078,available,https://doi.org/10.1101/2022.10.22.513328 +S260R,NP_000537:p.Ser260Arg,,,,,saturation_mutlist,,,,,,,,-0.29513,0.30789130210876464,,-0.5953931307531124,,-0.4452615653765562,,Neutral,Neutral,,Neutral,0.19125695203063348,,0.16859844887934877,-0.35042,,-0.19245549370753767,,-0.27143774685376887,,Neutral,,Neutral,,0.16688161645881752,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.0802,2.008,-0.8066,-1.01592776987403,0.0001437706925,Benign,0.4246,ambiguous,-3.118,available,https://doi.org/10.1101/2022.10.22.513328 +S260T,NP_000537:p.Ser260Thr,"hg19,17:g.7577503A>T",,,0.530,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.72891,0.276607882976532,0.4374133333333334,-0.07765369087554726,0.5831616666666667,0.3256281545622263,Neutral,Neutral,Neutral,Neutral,Neutral,0.2111182278576016,0.22044261798078477,0.2231825520000343,0.50815,0.005783333333333325,0.1769794424381319,0.2569666666666667,0.34256472121906595,Neutral,Neutral,Neutral,Neutral,0.569564588455271,0.21460392477499632,69.339,9.408,69.355,10.049,,True,69.339,,neutral,,,,True,69.355,,neutral,,,uncertain,,-0.0084,2.008,-6.9513,-1.98572016214949,0.0048245155574749,Benign,0.0865,benign,-3.246,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S260V,NP_000537:p.Ser260Val,,,,,saturation_mutlist,,,,,,,,0.70913,0.42513826608657834,,-0.30554089180208466,,0.2017945540989577,,Neutral,Neutral,,Neutral,0.3063737359360862,,0.21963628799351362,0.61053,,0.04887868392245529,,0.32970434196122766,,Neutral,,Neutral,,0.2615506358196124,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.1512,2.008,-22.239,-3.97940771885032,0.0525638560221948,Benign,0.1673,benign,-3.514,available,https://doi.org/10.1101/2022.10.22.513328 +S260W,NP_000537:p.Ser260Trp,,,,,saturation_mutlist,,,,,,,,0.23304,0.4311364769935608,,-0.8087629343179167,,-0.28786146715895833,,Neutral,Neutral,,Neutral,0.1938342423308777,,0.031115949067702483,0.41364,,-0.6423498387119816,,-0.11435491935599079,,Neutral,,Neutral,,0.28541200973090214,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.1835,2.008,-22.239,-4.1221197690896,0.471663584821703,Uncertain,0.3256,benign,-3.902,available,https://doi.org/10.1101/2022.10.22.513328 +S260Y,NP_000537:p.Ser260Tyr,"hg19,17:g.7577502G>T, hg38,17:g.7674184G>T",,3.9771552204e-06,0.668,"COSMIC,ClinVar,saturation_mutlist",231033,Likely benign,3,,,,,0.16688,0.47571861147880556,0.2494333333333333,-0.43306960573173797,0.20815666666666666,-0.133094802865869,Neutral,Neutral,Neutral,Neutral,Neutral,0.2506405450855614,0.21406683478660485,0.07579438770836049,0.10641,-0.04194666666666672,-0.06437695425988767,0.032231666666666645,0.02101652287005617,Neutral,Neutral,Neutral,Neutral,0.9053578156851699,0.25800842607904545,69.339,9.408,69.355,10.049,,True,69.339,,uncertain,,,,True,69.355,,uncertain,,,uncertain,,-0.1786,2.008,-22.239,-3.82739574834943,0.0730383899636282,Benign,0.2029,benign,-3.698,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261A,NP_000537:p.Ser261Ala,,,,,saturation_mutlist,,,,,,,,0.21345,0.09980189085006712,,0.12864297767160265,,0.1710464888358013,,Neutral,Neutral,,Neutral,0.042570261423680075,,0.2633739080852399,-0.12323,,0.23454883504474422,,0.05565941752237211,,Neutral,,Neutral,,0.09174132303760998,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,uncertain,,-0.055,1.7131,-8.9453,-2.04022371982166,0.0009756908758932,Benign,0.0873,benign,-3.25,available,https://doi.org/10.1101/2022.10.22.513328 +S261C,NP_000537:p.Ser261Cys,"hg38,17:g.7674182T>A",,,0.547,"COSMIC,saturation_mutlist",,,,,,,,0.45647,-0.31701193571090697,1.1284566666666667,0.7625621973382731,0.7924633333333333,0.6095160986691366,Neutral,Neutral,Neutral,Neutral,Neutral,0.10760489928341857,0.19121682532896758,0.24334949863641203,0.05661,0.81417,0.7832274504950013,0.43539,0.4199187252475007,Neutral,Neutral,Neutral,Neutral,0.8344939478909758,0.1035564738011182,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.1004,1.7131,-7.9454,-0.502208726640067,0.0178114924795914,Benign,0.087,benign,-3.37,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261D,NP_000537:p.Ser261Asp,,,,,saturation_mutlist,,,,,,,,0.42645,0.0125787615776062,,-0.11283446067767318,,0.15680776966116342,,Neutral,Neutral,,Neutral,0.07942366402180204,,0.25416463877857814,-0.04447,,0.0190617246209971,,-0.012704137689501451,,Neutral,,Neutral,,0.1906886387020026,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.1113,1.7131,-0.6462,-0.875788802920189,2.7135721951607856e-08,Benign,0.1721,benign,-2.992,available,https://doi.org/10.1101/2022.10.22.513328 +S261E,NP_000537:p.Ser261Glu,,,,,saturation_mutlist,,,,,,,,0.44903,0.02205954790115355,,-0.07848658049985952,,0.18527170975007023,,Neutral,Neutral,,Neutral,0.0800549546845434,,0.2750890902622886,0.04058,,0.23221770523372354,,0.13639885261686177,,Neutral,,Neutral,,0.06599984127284325,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.0971,1.7131,-3.1126,-0.946725575828048,1.50672951385436e-07,Benign,0.2859,benign,-3.047,available,https://doi.org/10.1101/2022.10.22.513328 +S261F,NP_000537:p.Ser261Phe,,,,,saturation_mutlist,,,,,,,,0.27412,-7.609844207762118e-05,,-0.12162450401237722,,0.07624774799381137,,Neutral,Neutral,,Neutral,0.1377153613994684,,0.35742568521027995,-0.2061,,-0.0025890319558306008,,-0.1043445159779153,,Neutral,,Neutral,,0.07900588538904169,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.2009,1.7131,-22.2332,-4.61296027217296,0.0588126939535827,Benign,0.2061,benign,-3.572,available,https://doi.org/10.1101/2022.10.22.513328 +S261G,NP_000537:p.Ser261Gly,"hg19,17:g.7577500T>C, hg38,17:g.7674182T>C",,,0.529,"COSMIC,ClinVar,saturation_mutlist",1383522,Conflicting classifications of pathogenicity,1,,,,,0.3611,0.3484243130683899,1.0819733333333335,0.6044109743174103,0.7215366666666667,0.48275548715870514,Neutral,Neutral,Neutral,Neutral,Neutral,0.1510341659630593,0.3163455754217038,0.04238308545322484,-0.69092,0.40623666666666675,0.412579561975424,-0.14234166666666662,-0.139170219012288,Neutral,Neutral,Neutral,Neutral,1.32123539604249,0.351395034779279,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,uncertain,,-0.0561,1.7131,-7.3604,-2.17914337186216,2.019823258804172e-06,Benign,0.0786,benign,-3.105,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261H,NP_000537:p.Ser261His,,,,,saturation_mutlist,,,,,,,,0.22239,-0.15530531406402587,,-0.2660266151465705,,-0.021818307573285248,,Neutral,Neutral,,Neutral,0.13702733409161555,,0.28061924083909956,0.06627,,-0.15684892028961375,,-0.04528946014480688,,Neutral,,Neutral,,0.14666924343744137,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.1224,1.7131,-6.6235,-2.5578206679946,8.879736881525837e-05,Benign,0.1504,benign,-3.187,available,https://doi.org/10.1101/2022.10.22.513328 +S261I,NP_000537:p.Ser261Ile,"hg19,17:g.7577499C>A, hg38,17:g.7674181C>A",,,0.532,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.80968,0.4250917112827301,1.0360566666666666,0.08597285542018733,0.9228683333333333,0.4478264277100936,Neutral,Neutral,Neutral,Neutral,Neutral,0.15940219381319276,0.21452939275436259,0.4157946131706431,0.87599,1.5800433333333332,0.6451700218362747,1.2280166666666665,0.7605800109181373,Neutral,Neutral,Neutral,Neutral,1.73936030559769,0.5932290404243029,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.204,1.7131,-22.2332,-4.59122588609972,0.031828400675512,Benign,0.205,benign,-3.695,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261K,NP_000537:p.Ser261Lys,,,,,saturation_mutlist,,,,,,,,-0.1239,0.01789036989212033,,-0.020658718895707504,,-0.07227935944785376,,Neutral,Neutral,,Neutral,0.05244239138761398,,0.13897931740563288,-0.38279,,0.13840535549697108,,-0.12219232225151447,,Neutral,,Neutral,,0.12800201980911682,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.1436,1.7131,-8.9453,-2.48110060430245,0.000458313553013,Benign,0.3333,benign,-3.306,available,https://doi.org/10.1101/2022.10.22.513328 +S261L,NP_000537:p.Ser261Leu,,,,,saturation_mutlist,,,,,,,,0.2516,0.0020698285102844316,,-0.35509924787036035,,-0.05174962393518018,,Neutral,Neutral,,Neutral,0.12782241034588585,,0.3550086166568502,-0.09515,,-0.2172612356406994,,-0.1562056178203497,,Neutral,,Neutral,,0.018375569980705744,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.1274,1.7131,-7.9454,-2.9753696704731,0.0026620882853516,Benign,0.1274,benign,-3.354,available,https://doi.org/10.1101/2022.10.22.513328 +S261M,NP_000537:p.Ser261Met,,,,,saturation_mutlist,,,,,,,,0.36602,-0.017734084129333482,,0.0024057917621709605,,0.1842128958810855,,Neutral,Neutral,,Neutral,0.09651954823444205,,0.3066591701563217,-0.09756,,0.04745499140336116,,-0.025052504298319418,,Neutral,,Neutral,,0.04974645667184485,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.1713,1.7131,-22.2332,-3.07376485559445,0.0002035752584973,Benign,0.187,benign,-3.428,available,https://doi.org/10.1101/2022.10.22.513328 +S261N,NP_000537:p.Ser261Asn,"hg19,17:g.7577499C>T, hg38,17:g.7674181C>T",,,0.446,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",4427935,,,,,,,-0.20078,-0.29481960535049434,0.21247333333333332,-0.16490202908868487,0.005846666666666667,-0.18284101454434243,Neutral,Neutral,Neutral,Neutral,Neutral,0.08539393111565391,0.25665985822138654,0.23292679354626836,-0.13838,-0.15839,-0.14375410191189333,-0.148385,-0.14106705095594668,Neutral,Neutral,Neutral,Neutral,0.9774861694503236,0.219486237199176,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.0565,1.7131,-4.858,0.403774820524704,2.1237138844390275e-08,Benign,0.08,benign,-2.92,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261P,NP_000537:p.Ser261Pro,,,,,saturation_mutlist,,,,,,,,1.25997,2.1755842065811155,,2.6923565478952667,,1.9761632739476334,,Uncertain,Destabilizing,,Neutral,0.26782942515505226,,0.9589888818842194,1.65641,,4.109708022920675,,2.8830590114603374,,Uncertain,,Uncertain,,1.0071820664342872,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.2763,1.7131,-22.2332,-5.36520861972928,0.2444873835395251,Benign,0.7656,pathogenic,-3.868,available,https://doi.org/10.1101/2022.10.22.513328 +S261Q,NP_000537:p.Ser261Gln,,,,,saturation_mutlist,,,,,,,,-0.09092,-0.11990125894546509,,0.12371826608444401,,0.016399133042222007,,Neutral,Neutral,,Neutral,0.10022839958312361,,0.25528008621224485,-0.06677,,0.29504644620903886,,0.11413822310451943,,Neutral,,Neutral,,0.04738014889096765,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.0851,1.7131,-6.6235,-1.11833664663487,4.135505109297147e-06,Benign,0.2217,benign,-3.077,available,https://doi.org/10.1101/2022.10.22.513328 +S261R,NP_000537:p.Ser261Arg,"hg19,17:g.7577500T>G, hg38,17:g.7673837A>C, hg38,17:g.7673837A>T, hg38,17:g.7674182T>G",,,"0.390, 0.391, 0.456","COSMIC,ClinVar,saturation_mutlist",3708635,Uncertain significance,1,,,,,-0.23751,0.02813782215118407,0.4817466666666667,-0.19293162857855684,0.12211833333333336,-0.21522081428927842,Neutral,Neutral,Neutral,Neutral,Neutral,0.0693443431250968,0.18606990126174505,0.19937185967190163,-0.57524,0.38276666666666664,-0.06928362102314135,-0.09623666666666666,-0.32226181051157066,Neutral,Neutral,Neutral,Neutral,0.26499594164607293,0.09125035206259462,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.137,1.7131,-6.6235,-1.20713191968725,0.0029405925469668,Benign,0.2371,benign,-3.265,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261T,NP_000537:p.Ser261Thr,"hg19,17:g.7577499C>G, hg19,17:g.7674181C>G, hg38,17:g.7674181C>G",,,0.504,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",187005,Uncertain significance,2,,,,,0.50128,0.030693933963775635,-0.06893666666666666,0.07524547860070525,0.21617166666666665,0.2882627393003526,Neutral,Neutral,Neutral,Neutral,Neutral,0.1241913733370788,0.15955586405881658,0.2655730171883184,0.37929,0.28628333333333333,0.5361739436874172,0.3327866666666667,0.4577319718437086,Neutral,Neutral,Neutral,Neutral,0.35202459633131067,0.4261627255816993,75.617,7.15,90.695,19.761,,True,75.617,,neutral,,,,True,90.695,,neutral,,,neutral,,-0.1135,1.7131,-22.2332,-2.87081743695043,0.0007919516612992,Benign,0.0875,benign,-3.192,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261V,NP_000537:p.Ser261Val,,,,,saturation_mutlist,,,,,,,,1.04761,0.3846442151069641,,0.08149290945078376,,0.5645514547253918,,Neutral,Neutral,,Neutral,0.16599060264350457,,0.3940907843838616,0.84309,,0.5836408633616865,,0.7133654316808433,,Neutral,,Neutral,,0.46210005072552846,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.1783,1.7131,-22.2332,-4.59122588609972,0.002339587213864,Benign,0.1984,benign,-3.696,available,https://doi.org/10.1101/2022.10.22.513328 +S261W,NP_000537:p.Ser261Trp,,,,,saturation_mutlist,,,,,,,,0.52927,0.05242028474807738,,-0.5425370609757026,,-0.0066335304878513135,,Neutral,Neutral,,Neutral,0.11077510400593565,,0.47756088646777073,0.04232,,-0.22179940292224987,,-0.08973970146112493,,Neutral,,Neutral,,0.0682492016084279,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.2106,1.7131,-22.2332,-4.61296027217296,0.2317543290742702,Benign,0.3039,benign,-3.899,available,https://doi.org/10.1101/2022.10.22.513328 +S261Y,NP_000537:p.Ser261Tyr,,,,,saturation_mutlist,,,,,,,,0.33345,0.0223019790649414,,-0.048483188753245386,,0.14248340562337733,,Neutral,Neutral,,Neutral,0.1574518521290844,,0.36913344495500866,-0.10179,,0.07241836196986996,,-0.014685819015065021,,Neutral,,Neutral,,0.0554292198652536,75.617,7.15,90.695,19.761,,True,75.617,,uncertain,,,,True,90.695,,uncertain,,,neutral,,-0.2057,1.7131,-22.2332,-4.61296027217296,0.328653743854079,Uncertain,0.174,benign,-3.716,available,https://doi.org/10.1101/2022.10.22.513328 +G262A,NP_000537:p.Gly262Ala,,,,,saturation_mutlist,,,,,,,,3.26795,1.5228257036209107,,1.2295238935884847,,2.248736946794242,,Uncertain,Uncertain,,Uncertain,0.1682464980854846,,0.3798748780507734,2.6097,,1.0269035258723924,,1.8183017629361964,,Uncertain,,Neutral,,0.4941459582450218,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.3782,0.0592,-22.2332,-5.73364708026077,0.5294729414423727,Uncertain,0.8367,pathogenic,-3.786,available,https://doi.org/10.1101/2022.10.22.513328 +G262C,NP_000537:p.Gly262Cys,"hg19,17:g.7577154C>A",,,0.865,"cBioPortal,saturation_mutlist",,,,,,,,3.37647,0.7959802913665771,1.612243333333333,1.6770803132444552,2.4943566666666666,2.5267751566222274,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.15697142493682803,0.2970683133931019,0.35689814342115167,2.75062,1.1336733333333333,1.5087640246850447,1.9421466666666667,2.1296920123425225,Uncertain,Uncertain,Neutral,Uncertain,1.0655597388018916,0.4049933157579775,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.4379,0.0592,-22.2332,-6.35039706060677,0.7372361459513241,Pathogenic,0.8435,pathogenic,-3.974,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G262D,NP_000537:p.Gly262Asp,"hg19,17:g.7577153C>T, hg19,17:g.7673835C>T, hg38,17:g.7673835C>T",,,0.931,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2993845,Uncertain significance,1,,,,,3.85423,1.314012279510498,0.92211,0.6697908506490645,2.3881699999999997,2.262010425324532,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.19583774655089597,0.8050788177977773,0.4450999986492642,2.68937,0.2741466666666666,0.6003830252963843,1.4817583333333333,1.6448765126481921,Uncertain,Uncertain,Neutral,Neutral,1.4140351316789206,0.4825313988083425,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.4385,0.0592,-22.2332,-5.37575011432035,0.5855638912025629,Uncertain,0.9609,pathogenic,-3.886,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G262E,NP_000537:p.Gly262Glu,,,,,saturation_mutlist,,,,,,,,3.43402,1.4797699022293092,,0.9352774363839251,,2.1846487181919625,,Uncertain,Uncertain,,Uncertain,0.24130477639894957,,0.4073239144284425,2.89021,,0.7853439906106088,,1.8377769953053045,,Uncertain,,Neutral,,0.5519316110461702,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.3649,0.0592,-7.9454,-4.18735712970854,0.1193809237587507,Benign,0.9553,pathogenic,-3.754,available,https://doi.org/10.1101/2022.10.22.513328 +G262F,NP_000537:p.Gly262Phe,,,,,saturation_mutlist,,,,,,,,3.33336,1.3989814805984497,,0.8516040873527979,,2.092482043676399,,Uncertain,Uncertain,,Uncertain,0.15227402033249537,,0.33535878557596493,2.80603,,0.6941704670500695,,1.7501002335250346,,Uncertain,,Neutral,,0.5637443197454998,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.476,0.0592,-22.2332,-7.33538990925361,0.8677240979352827,Pathogenic,0.9877,pathogenic,-4.323,available,https://doi.org/10.1101/2022.10.22.513328 +G262H,NP_000537:p.Gly262His,"hg38,17:g.7673835_7673836delinsTG",,,,"COSMIC,saturation_mutlist",,,,,,,,3.59509,1.3069995474815368,0.18832000000000002,0.5676148990046804,1.891705,2.08135244950234,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,0.23129042783494996,0.4687953413448843,0.3717246296686162,2.91738,-0.10385666666666671,0.4254072128410191,1.4067616666666667,1.6713936064205095,Uncertain,Uncertain,Neutral,Neutral,0.7939305565490109,0.4924198977928484,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.4508,0.0592,-22.2332,-7.33538990925361,0.8707630531421902,Pathogenic,0.9694,pathogenic,-4.323,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G262I,NP_000537:p.Gly262Ile,"hg19,17:g.7577153_7577154delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,4.74005,2.0249766397476194,,2.1631935182054964,,3.451621759102748,,Uncertain,Destabilizing,,Destabilizing,0.19411493098794064,,0.526369601028984,4.65304,,1.7758008068746876,,3.2144204034373436,,Uncertain,,Destabilizing,,1.1227319621253322,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.5217,0.0592,-22.2332,-7.33538990925361,0.869555621585437,Pathogenic,0.9959,pathogenic,-4.623,available,https://doi.org/10.1101/2022.10.22.513328 +G262K,NP_000537:p.Gly262Lys,,,,,saturation_mutlist,,,,,,,,3.11146,1.592626190185547,,0.6646276045928646,,1.8880438022964323,,Uncertain,Uncertain,,Neutral,0.2686174959970979,,0.4173289955801933,2.45346,,0.5504012674054223,,1.5019306337027112,,Uncertain,,Neutral,,0.4251153570520689,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.4707,0.0592,-22.2332,-6.36573150035049,0.5632845925303624,Uncertain,0.9793,pathogenic,-3.985,available,https://doi.org/10.1101/2022.10.22.513328 +G262L,NP_000537:p.Gly262Leu,,,,,saturation_mutlist,,,,,,,,3.3501,1.5499708223342896,,0.7820128803571519,,2.066056440178576,,Uncertain,Uncertain,,Uncertain,0.1857515609955562,,0.4007141706826985,3.06424,,0.6588265946467493,,1.8615332973233745,,Uncertain,,Neutral,,0.6473628930747597,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.4899,0.0592,-22.2332,-7.11273424087202,0.8518611188844114,Pathogenic,0.9785,pathogenic,-4.271,available,https://doi.org/10.1101/2022.10.22.513328 +G262M,NP_000537:p.Gly262Met,,,,,saturation_mutlist,,,,,,,,3.32858,1.4073323178291322,,0.9121278051806616,,2.120353902590331,,Uncertain,Uncertain,,Uncertain,0.2200483532768112,,0.3814891819207666,2.84924,,0.871119801522958,,1.860179900761479,,Uncertain,,Neutral,,0.5216201423893023,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.4282,0.0592,-22.2332,-7.33538990925361,0.87010628774238,Pathogenic,0.9865,pathogenic,-4.345,available,https://doi.org/10.1101/2022.10.22.513328 +G262N,NP_000537:p.Gly262Asn,,,,,saturation_mutlist,,,,,,,,3.20904,1.09287757396698,,0.3954208857823813,,1.8022304428911906,,Uncertain,Uncertain,,Neutral,0.2680922376056149,,0.36169387095732086,2.32755,,0.47931117219048835,,1.403430586095244,,Uncertain,,Neutral,,0.31361090496940763,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.4388,0.0592,-22.2332,-5.0085921961254,0.3904992615459105,Uncertain,0.925,pathogenic,-3.722,available,https://doi.org/10.1101/2022.10.22.513328 +G262P,NP_000537:p.Gly262Pro,,,,,saturation_mutlist,,,,,,,,7.0662,2.3150290632247925,,7.063580678826937,,7.064890339413468,,Destabilizing,Destabilizing,,Destabilizing,0.242725701455823,,0.27191947233185565,6.17632,,4.399123236331373,,5.287721618165686,,Destabilizing,,Destabilizing,,2.5785411824634252,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.5359,0.0592,-22.2332,-7.86384531971252,0.8708566439614697,Pathogenic,0.9987,pathogenic,-4.539,available,https://doi.org/10.1101/2022.10.22.513328 +G262Q,NP_000537:p.Gly262Gln,,,,,saturation_mutlist,,,,,,,,3.13347,1.4975400805473327,,1.0176408114899393,,2.0755554057449697,,Uncertain,Uncertain,,Uncertain,0.26903622914286257,,0.4016424443443122,2.7135,,0.9358523695853469,,1.8246761847926734,,Uncertain,,Neutral,,0.4916713629883612,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.4417,0.0592,-22.2332,-5.49734300582471,0.6488772924991666,Uncertain,0.9255,pathogenic,-4.045,available,https://doi.org/10.1101/2022.10.22.513328 +G262R,NP_000537:p.Gly262Arg,"hg19,17:g.7577154C>G, hg38,17:g.7673836C>G",,,0.889,"COSMIC,ClinVar,saturation_mutlist",1760888,Uncertain significance,1,,,,,3.06349,1.6307548332214354,1.1053300000000001,0.5731721216165421,2.08441,1.818331060808271,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.23345027053747325,0.25558997998095834,0.36171050625528567,2.37086,0.41575999999999996,0.4686261313112315,1.39331,1.4197430656556158,Uncertain,Uncertain,Neutral,Neutral,0.9085449032748282,0.46108235959354354,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.4547,0.0592,-22.2332,-5.79806747256491,0.5403141050472513,Uncertain,0.9274,pathogenic,-3.918,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G262S,NP_000537:p.Gly262Ser,"hg19,17:g.7577154C>T, hg19,17:g.7673836C>T, hg38,17:g.7673836C>T",3.186336987e-05,8.1725386357e-06,0.876,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141228,Likely benign,3,,,,,3.38688,1.490064435005188,1.2088433333333333,1.1987842052932995,2.297861666666667,2.29283210264665,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.17109776384390665,0.203659075472276,0.3039590648953969,2.60765,0.08877333333333337,0.9447076731359343,1.3482116666666668,1.7761788365679672,Uncertain,Uncertain,Neutral,Neutral,1.003350172184279,0.5597452577597665,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.3841,0.0592,-22.2332,-6.34618526957259,0.7282729553086548,Pathogenic,0.6981,pathogenic,-3.856,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G262T,NP_000537:p.Gly262Thr,,,,,saturation_mutlist,,,,,,,,4.47328,1.8323469591140746,,1.820146259034549,,3.1467131295172743,,Uncertain,Uncertain,,Destabilizing,0.1620849369764397,,0.35440000280762685,4.16549,,1.4138706826356744,,2.7896803413178373,,Uncertain,,Uncertain,,0.9174070913562442,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.3932,0.0592,-8.9453,-6.23904282959436,0.6711767143021219,Uncertain,0.9573,pathogenic,-4.229,available,https://doi.org/10.1101/2022.10.22.513328 +G262V,NP_000537:p.Gly262Val,"hg19,17:g.7577153C>A, hg19,17:g.7673835C>A, hg38,17:g.7673835C>A",,,0.929,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428889,Conflicting classifications of pathogenicity,1,Uncertain significance,1,,,4.87142,2.0144933319091796,5.258506666666666,2.0241848450052746,5.064963333333333,3.447802422502637,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.19552502310467323,0.45889719766220183,0.3647211786459621,4.41467,3.6868466666666664,1.5093872576429437,4.0507583333333335,2.962028628821472,Destabilizing,Uncertain,Destabilizing,Uncertain,2.5928241264219127,0.958821485296574,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.465,0.0592,-22.2332,-7.33538990925361,0.8705260902226395,Pathogenic,0.9878,pathogenic,-4.432,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G262W,NP_000537:p.Gly262Trp,,,,,saturation_mutlist,,,,,,,,3.76477,1.5890575075149536,,0.6019497166640071,,2.1833598583320035,,Uncertain,Uncertain,,Uncertain,0.1323929904681902,,0.36090144595438706,3.19299,,0.43867986453203384,,1.815834932266017,,Uncertain,,Neutral,,0.6217225892145739,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.4758,0.0592,-22.2332,-7.33538990925361,0.8703351197825077,Pathogenic,0.973,pathogenic,-4.484,available,https://doi.org/10.1101/2022.10.22.513328 +G262Y,NP_000537:p.Gly262Tyr,,,,,saturation_mutlist,,,,,,,,3.44994,1.5131769800186157,,0.8715833568158664,,2.1607616784079333,,Uncertain,Uncertain,,Uncertain,0.14913820763578348,,0.3295303822630652,2.89153,,0.7553100486956801,,1.82342002434784,,Uncertain,,Neutral,,0.585052035097003,55.277,10.136,84.605,24.702,,False,55.277,,neutral,neutral,neutral,,False,84.605,,neutral,neutral,neutral,uncertain,,-0.4764,0.0592,-22.2332,-7.15246193613362,0.8068636906846784,Pathogenic,0.9783,pathogenic,-4.259,available,https://doi.org/10.1101/2022.10.22.513328 +N263A,NP_000537:p.Asn263Ala,,,,,saturation_mutlist,,,,,,,,0.12166,0.2055549454689026,,0.06730055371941526,,0.09448027685970764,,Neutral,Neutral,,Neutral,0.1029974047158525,,0.2515977469273099,-0.04958,,0.4381784384865693,,0.19429921924328464,,Neutral,,Neutral,,0.2524671727204267,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.1077,1.6112,-7.9454,-3.5389879530537,0.0008577695200733,Benign,0.1647,benign,-3.205,available,https://doi.org/10.1101/2022.10.22.513328 +N263C,NP_000537:p.Asn263Cys,,,,,saturation_mutlist,,,,,,,,0.30594,-0.017084155082702616,,0.5881876089667618,,0.4470638044833809,,Neutral,Neutral,,Neutral,0.06965914644966724,,0.19359048489473493,0.1202,,0.936070812416741,,0.5281354062083705,,Neutral,,Neutral,,0.081756306487728,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.2305,1.6112,-22.2332,-4.44360904561772,0.002433512474041,Benign,0.1377,benign,-3.448,available,https://doi.org/10.1101/2022.10.22.513328 +N263D,NP_000537:p.Asn263Asp,"hg19,17:g.7577151T>C, hg38,17:g.7673833T>C",,0.0001136465106462,0.315,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142916,Conflicting classifications of pathogenicity,1,,,,,0.38209,0.6834776496887207,0.36667,0.22265544900698267,0.37438,0.30237272450349134,Neutral,Neutral,Neutral,Neutral,Neutral,0.09566146296533401,0.44035958314389695,0.32401238482153133,-0.08714,0.2438766666666667,0.43402181555905867,0.07836833333333336,0.17344090777952934,Neutral,Neutral,Neutral,Neutral,0.401167464810174,0.13059390911342533,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.116,1.6112,-8.9453,-3.16059060505359,0.0154966667641783,Benign,0.2109,benign,-3.394,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N263E,NP_000537:p.Asn263Glu,,,,,saturation_mutlist,,,,,,,,0.06398,0.4859950184822083,,0.023048374622867296,,0.043514187311433646,,Neutral,Neutral,,Neutral,0.10725676507094453,,0.28634516509205044,-0.19261,,0.380280459872512,,0.09383522993625601,,Neutral,,Neutral,,0.17821847571245775,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.1329,1.6112,-6.9454,-1.96554421769677,0.0001133959187897,Benign,0.2544,benign,-3.136,available,https://doi.org/10.1101/2022.10.22.513328 +N263F,NP_000537:p.Asn263Phe,,,,,saturation_mutlist,,,,,,,,-0.35603,0.39980484008789063,,-0.48980815778515946,,-0.42291907889257974,,Neutral,Neutral,,Neutral,0.09734569388889461,,0.16698335064017772,-0.27687,,-0.17787347476663715,,-0.22737173738331856,,Neutral,,Neutral,,0.028224680223013908,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.17,1.6112,-8.9453,-5.36611076407854,0.0385483194555927,Benign,0.3972,ambiguous,-3.668,available,https://doi.org/10.1101/2022.10.22.513328 +N263G,NP_000537:p.Asn263Gly,,,,,saturation_mutlist,,,,,,,,0.54428,0.7641952466964722,,0.8344316363432144,,0.6893558181716072,,Neutral,Neutral,,Neutral,0.10923976802893233,,0.25254981159692313,0.20026,,1.0036397739827676,,0.6019498869913837,,Neutral,,Neutral,,0.1582354944324844,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.1436,1.6112,-8.9453,-5.96632723085024,0.0408853670464283,Benign,0.2986,benign,-3.467,available,https://doi.org/10.1101/2022.10.22.513328 +N263H,NP_000537:p.Asn263His,"hg19,17:g.7577151T>G, hg38,17:g.7673833T>G, hg38,17:g.7673833_7673834delinsGT",,,0.315,"COSMIC,ClinVar,saturation_mutlist",528251,Uncertain significance,1,,,,,0.26124,0.08071473598480222,0.15589666666666666,-0.3601822050169516,0.20856833333333336,-0.04947110250847578,Neutral,Neutral,Neutral,Neutral,Neutral,0.07127607510323074,0.42158604375487685,0.15963366326025666,0.1084,0.1549866666666667,-0.021046327820395564,0.13169333333333333,0.04367683608980222,Neutral,Neutral,Neutral,Neutral,0.2896690181722735,0.06385852150233098,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.1076,1.6112,-6.9454,-2.09937785895099,3.017920159696205e-05,Benign,0.0689,benign,-3.13,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N263I,NP_000537:p.Asn263Ile,"hg38,17:g.7673832T>A",,,0.318,"COSMIC,saturation_mutlist",,,,,,,,-0.04339,0.31004661083221435,0.5277733333333333,-0.497341475248189,0.24219166666666667,-0.2703657376240945,Neutral,Neutral,Neutral,Neutral,Neutral,0.15726525438102895,0.2058149706788978,0.13320356982080303,0.07369,1.1387766666666668,0.1870372523874799,0.6062333333333334,0.13036362619373995,Neutral,Neutral,Neutral,Neutral,0.38927801036734094,0.10431740282706341,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.158,1.6112,-7.9454,-3.16992684680608,0.0020597620732658,Benign,0.1494,benign,-3.474,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N263K,NP_000537:p.Asn263Lys,"hg19,17:g.7577149A>C, hg19,17:g.7577149A>T, hg38,17:g.7673831A>C, hg38,17:g.7673831A>T",,,0.213,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",485047,Uncertain significance,1,,,,,-0.45728,-0.11929192066192627,0.0037400000000000024,-0.16644423739294611,-0.22677,-0.31186211869647307,Neutral,Neutral,Neutral,Neutral,Neutral,0.10531073801385235,0.5899505757829775,0.29062362693071037,-0.50083,0.34898,0.2693171982714052,-0.07592499999999999,-0.11575640086429739,Neutral,Neutral,Neutral,Neutral,0.10847103207769344,0.211580395422742,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.0999,1.6112,-5.7755,-1.63217552242182,5.5317864002968575e-05,Benign,0.1437,benign,-3.045,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N263L,NP_000537:p.Asn263Leu,,,,,saturation_mutlist,,,,,,,,-0.24976,0.2674508500099182,,-0.639345833281031,,-0.4445529166405155,,Neutral,Neutral,,Neutral,0.08167307101084924,,0.07270572936272943,-0.35782,,-0.3151831654793506,,-0.33650158273967534,,Neutral,,Neutral,,0.16333394144382676,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.1447,1.6112,-4.0875,-2.72522943396324,7.365307303741582e-05,Benign,0.1829,benign,-3.088,available,https://doi.org/10.1101/2022.10.22.513328 +N263M,NP_000537:p.Asn263Met,,,,,saturation_mutlist,,,,,,,,-0.2645,0.1815298342704773,,-0.24942844834788236,,-0.25696422417394116,,Neutral,Neutral,,Neutral,0.08756559343876165,,0.13842560161497777,-0.46417,,0.04027442391445813,,-0.21194778804277095,,Neutral,,Neutral,,0.07815279591982485,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.1156,1.6112,-7.3604,-3.07863998203176,0.0002815627503223,Benign,0.2242,benign,-3.378,available,https://doi.org/10.1101/2022.10.22.513328 +N263P,NP_000537:p.Asn263Pro,,,,,saturation_mutlist,,,,,,,,2.05219,2.7921845531463623,,3.682837536081278,,2.867513768040639,,Uncertain,Destabilizing,,Uncertain,0.2808905148101642,,0.6509715829154737,1.1257,,3.8999401040730564,,2.512820052036528,,Uncertain,,Uncertain,,0.9833797348657067,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.3462,1.6112,-22.2332,-4.62100007272057,0.2487050287926423,Benign,0.9564,pathogenic,-3.915,available,https://doi.org/10.1101/2022.10.22.513328 +N263Q,NP_000537:p.Asn263Gln,,,,,saturation_mutlist,,,,,,,,-0.27181,0.0354492998123169,,0.0738981456490921,,-0.09895592717545396,,Neutral,Neutral,,Neutral,0.09129641301494847,,0.26077077275343674,-0.31375,,0.4482080397209716,,0.06722901986048582,,Neutral,,Neutral,,0.16598999334317494,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.0639,1.6112,-0.5446,-0.947771734445837,7.045683281580252e-10,Benign,0.1273,benign,-2.794,available,https://doi.org/10.1101/2022.10.22.513328 +N263R,NP_000537:p.Asn263Arg,,,,,saturation_mutlist,,,,,,,,-0.60737,-0.2273918104171753,,-0.46182909657393667,,-0.5345995482869683,,Neutral,Neutral,,Neutral,0.09144490007722827,,0.19097095382995843,-0.55191,,-0.025449130887272672,,-0.2886795654436363,,Neutral,,Neutral,,0.19089997077182236,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.138,1.6112,-6.9454,-2.8855157720337,4.662204485019185e-05,Benign,0.1343,benign,-3.044,available,https://doi.org/10.1101/2022.10.22.513328 +N263S,NP_000537:p.Asn263Ser,"hg19,17:g.7577150T>C, hg38,17:g.7673832T>C",,,0.243,"cBioPortal,ClinVar,saturation_mutlist",827313,Likely benign,1,,,,,0.30559,0.23981974840164186,0.2605433333333333,0.2905236907312399,0.28306666666666663,0.29805684536561994,Neutral,Neutral,Neutral,Neutral,Neutral,0.059391691892011746,0.7176405223756219,0.3698332187530192,0.13613,0.05612333333333334,0.6130642010263322,0.09612666666666667,0.3745971005131661,Neutral,Neutral,Neutral,Neutral,0.2524344702206011,0.12875031561019137,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.0776,1.6112,-7.9454,-2.50718463114567,3.469311402443688e-06,Benign,0.093,benign,-3.085,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N263T,NP_000537:p.Asn263Thr,,,,,saturation_mutlist,,,,,,,,0.26769,0.22140926837921138,,0.006504719508867829,,0.1370973597544339,,Neutral,Neutral,,Neutral,0.11524426751278284,,0.2539415729009682,0.38973,,0.5180108715020363,,0.45387043575101815,,Neutral,,Neutral,,0.16637557737557648,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.1323,1.6112,-8.9453,-1.75573272354967,0.0114854338353704,Benign,0.1154,benign,-3.274,available,https://doi.org/10.1101/2022.10.22.513328 +N263V,NP_000537:p.Asn263Val,,,,,saturation_mutlist,,,,,,,,0.24526,0.1627678894996643,,-0.3886094376387829,,-0.07167471881939146,,Neutral,Neutral,,Neutral,0.15597728811762773,,0.0650328315265815,0.36919,,0.2762713186020754,,0.3227306593010377,,Neutral,,Neutral,,0.09186390653682816,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.1446,1.6112,-6.6235,-3.06010693003711,2.838152577811049e-05,Benign,0.1438,benign,-3.202,available,https://doi.org/10.1101/2022.10.22.513328 +N263W,NP_000537:p.Asn263Trp,,,,,saturation_mutlist,,,,,,,,0.0218,0.4827207827568054,,-0.7693369845835694,,-0.37376849229178466,,Neutral,Neutral,,Neutral,0.10625073756089974,,0.1572521019632335,0.10939,,-0.4575637275443139,,-0.17408686377215696,,Neutral,,Neutral,,0.08371210787620445,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.2429,1.6112,-22.2332,-5.36611076407854,0.4892516326995746,Uncertain,0.6572,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328 +N263Y,NP_000537:p.Asn263Tyr,"hg19,17:g.7577151T>A, hg38,17:g.7673833T>A",,,0.446,"cBioPortal,ClinVar,saturation_mutlist",1364128,Uncertain significance,1,,,,,-0.23879,0.32214884042739866,0.03763999999999997,-0.42155620979476205,-0.10057500000000001,-0.33017310489738105,Neutral,Neutral,Neutral,Neutral,Neutral,0.10219049320103885,0.5163842835201965,0.16203177670084087,-0.16568,0.3057833333333333,-0.08446053750493267,0.07005166666666665,-0.12507026875246632,Neutral,Neutral,Neutral,Neutral,0.19254626272376435,0.06999024916246753,61.818,4.34,78.84,17.482,,False,61.818,,neutral,neutral,neutral,,False,78.84,,neutral,neutral,neutral,uncertain,,-0.2213,1.6112,-22.2332,-5.07098975814963,0.0085550212982532,Benign,0.1443,benign,-3.644,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L264A,NP_000537:p.Leu264Ala,,,,,saturation_mutlist,,,,,,,,1.85057,1.5365340614318848,,2.195403113171173,,2.0229865565855865,,Uncertain,Uncertain,,Uncertain,0.22600024478395297,,0.31115508986217216,0.19057,,1.750737778714112,,0.970653889357056,,Neutral,,Neutral,,0.4609848313087347,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,neutral,,-0.3237,1.041,-22.2273,-5.24287573150059,0.6821823319582183,Pathogenic,0.8098,pathogenic,-3.996,available,https://doi.org/10.1101/2022.10.22.513328 +L264C,NP_000537:p.Leu264Cys,,,,,saturation_mutlist,,,,,,,,1.50811,0.8434454870223999,,2.3897779830939547,,1.9489439915469773,,Uncertain,Neutral,,Neutral,0.21952984877842924,,0.1737731591037758,0.38822,,2.060505814212861,,1.2243629071064306,,Uncertain,,Neutral,,0.4347131052178284,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,neutral,,-0.3129,1.041,-22.2273,-4.36502341035108,0.2538362157130683,Benign,0.7742,pathogenic,-3.728,available,https://doi.org/10.1101/2022.10.22.513328 +L264D,NP_000537:p.Leu264Asp,,,,,saturation_mutlist,,,,,,,,1.60774,1.7217607116699218,,2.3830758650224926,,1.9954079325112462,,Uncertain,Uncertain,,Neutral,0.24244925361810465,,0.4533933592103049,0.88107,,2.2160785314308638,,1.5485742657154318,,Uncertain,,Neutral,,1.1617279914361216,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,neutral,,-0.4452,1.041,-22.2273,-5.4905070548635,0.2408600521336015,Benign,0.9863,pathogenic,-4.22,available,https://doi.org/10.1101/2022.10.22.513328 +L264E,NP_000537:p.Leu264Glu,,,,,saturation_mutlist,,,,,,,,1.34128,1.4755780220031738,,1.9722233043649509,,1.6567516521824754,,Neutral,Uncertain,,Neutral,0.2726435797529377,,0.41554374981411135,1.25845,,2.08905797522568,,1.67375398761284,,Uncertain,,Neutral,,1.0730346850610326,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,neutral,,-0.4133,1.041,-22.2273,-5.2808123547975,0.2853288435570334,Benign,0.9408,pathogenic,-4.059,available,https://doi.org/10.1101/2022.10.22.513328 +L264F,NP_000537:p.Leu264Phe,,,,,saturation_mutlist,,,,,,,,1.55409,0.9101405739784241,,0.770148992508011,,1.1621194962540056,,Neutral,Neutral,,Neutral,0.28798992049444055,,0.308733773467917,0.74963,,0.7969260072095686,,0.7732780036047844,,Neutral,,Neutral,,0.8682506748242161,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,uncertain,,-0.2571,1.041,-22.2273,-6.5461871813981,0.7852998097224846,Pathogenic,0.7496,pathogenic,-4.215,available,https://doi.org/10.1101/2022.10.22.513328 +L264G,NP_000537:p.Leu264Gly,,,,,saturation_mutlist,,,,,,,,2.33477,2.237506866455078,,3.1943870949376696,,2.764578547468835,,Uncertain,Destabilizing,,Uncertain,0.23867863436661715,,0.5467549805106219,-0.01029,,2.8551352434649533,,1.4224226217324767,,Uncertain,,Neutral,,0.6319226530422749,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,neutral,,-0.3985,1.041,-22.2273,-6.5461871813981,0.8297180068720659,Pathogenic,0.9577,pathogenic,-4.449,available,https://doi.org/10.1101/2022.10.22.513328 +L264H,NP_000537:p.Leu264His,,,,,saturation_mutlist,,,,,,,,2.01402,1.7070918464660645,,1.464316901577128,,1.739168450788564,,Uncertain,Uncertain,,Neutral,0.2829347138294492,,0.2846331445956602,1.01268,,1.2740770321407056,,1.143378516070353,,Neutral,,Neutral,,0.8249208003753511,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,neutral,,-0.366,1.041,-22.2273,-6.5461871813981,0.6636074140855083,Uncertain,0.9052,pathogenic,-4.158,available,https://doi.org/10.1101/2022.10.22.513328 +L264I,NP_000537:p.Leu264Ile,"hg19,17:g.7577148G>T, hg38,17:g.7673830G>T",,,0.378,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",640121,Uncertain significance,1,,,,,0.72618,0.02511242389678955,0.07437666666666669,0.49075756474255644,0.40027833333333335,0.6084687823712782,Neutral,Neutral,Neutral,Neutral,Neutral,0.3109764515441372,0.6863310311763237,0.08668154693311349,0.67775,0.5692699999999999,1.0830204891194395,0.62351,0.8803852445597198,Neutral,Neutral,Neutral,Neutral,0.6892576162800089,0.7523160284033698,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,uncertain,,-0.1181,1.041,-6.6176,-1.87427155223024,0.0002595743008387,Benign,0.1043,benign,-3.25,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L264K,NP_000537:p.Leu264Lys,,,,,saturation_mutlist,,,,,,,,1.23972,1.6706038236618042,,2.104602028526122,,1.672161014263061,,Uncertain,Uncertain,,Neutral,0.24686209368373407,,0.34739267138206287,0.81378,,1.6936208261037915,,1.2537004130518956,,Neutral,,Neutral,,0.7474621484974865,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,uncertain,,-0.4123,1.041,-22.2273,-6.5461871813981,0.7892828327528014,Pathogenic,0.9339,pathogenic,-4.334,available,https://doi.org/10.1101/2022.10.22.513328 +L264M,NP_000537:p.Leu264Met,,,,,saturation_mutlist,,,,,,,,0.24258,0.6891790413856507,,1.0265198832757376,,0.6345499416378688,,Neutral,Neutral,,Neutral,0.16316137812631948,,0.1181392262099512,-0.12199,,1.0421390807192468,,0.46007454035962336,,Neutral,,Neutral,,0.7295675899192181,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,uncertain,,-0.1482,1.041,-7.9395,-1.71456015363385,0.3599754373194359,Uncertain,0.2687,benign,-3.73,available,https://doi.org/10.1101/2022.10.22.513328 +L264N,NP_000537:p.Leu264Asn,,,,,saturation_mutlist,,,,,,,,1.85069,1.912969822883606,,1.913120482902136,,1.881905241451068,,Neutral,Uncertain,,Neutral,0.23654629288364523,,0.28809303273503006,0.4796,,1.6047885437398175,,1.0421942718699087,,Neutral,,Neutral,,0.6423361066172524,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,neutral,,-0.3915,1.041,-22.2273,-5.75837237714931,0.8481105964048743,Pathogenic,0.9085,pathogenic,-4.354,available,https://doi.org/10.1101/2022.10.22.513328 +L264P,NP_000537:p.Leu264Pro,"hg19,17:g.7577147A>G, hg38,17:g.7673829A>G",,,0.831,"COSMIC,ClinVar,saturation_mutlist",480759,Uncertain significance,2,,,,,1.19343,1.4342056274414063,1.4607700000000001,2.804494071784703,1.3271000000000002,1.9989620358923514,Neutral,Uncertain,Uncertain,Neutral,Neutral,0.25356129120977283,0.5181472642663152,0.3947184801514624,1.71648,3.5897966666666665,3.9286777756744358,2.653138333333333,2.822578887837218,Uncertain,Uncertain,Uncertain,Uncertain,2.7346425945917603,2.6447209929786983,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,neutral,,-0.3312,1.041,-7.3546,-3.41572466550931,0.2349656202404051,Benign,0.8569,pathogenic,-3.679,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L264Q,NP_000537:p.Leu264Gln,"hg38,17:g.7673829A>T",,,0.813,"COSMIC,saturation_mutlist",,,,,,,,1.48768,1.5667350721359252,1.12857,1.7752737215263235,1.308125,1.6314768607631618,Neutral,Neutral,Uncertain,Neutral,Neutral,0.2554418958792764,0.2891394805279971,0.21456032367088612,0.79918,0.30295,1.6114997815726066,0.551065,1.2053398907863033,Neutral,Neutral,Neutral,Neutral,0.386013091228782,0.800793892824498,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,neutral,,-0.3444,1.041,-22.2273,-5.75837237714931,0.8582935796690372,Pathogenic,0.8352,pathogenic,-4.15,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L264R,NP_000537:p.Leu264Arg,"hg19,17:g.7577147A>C, hg19,17:g.7673829A>C, hg38,17:g.7673829A>C",,,0.822,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.47551,1.8404258918762206,1.8269833333333334,1.6210236451451898,1.6512466666666668,1.5482668225725948,Neutral,Neutral,Uncertain,Neutral,Neutral,0.29274863588177036,0.22825828649921026,0.2122481743763433,1.50831,2.0405933333333333,1.2001027371086213,1.7744516666666668,1.3542063685543106,Uncertain,Neutral,Neutral,Neutral,1.3163750960961782,0.5449889273512541,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,uncertain,,-0.4039,1.041,-22.2273,-6.5461871813981,0.7901559440941178,Pathogenic,0.8804,pathogenic,-4.239,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L264S,NP_000537:p.Leu264Ser,,,,,saturation_mutlist,,,,,,,,2.18088,1.7310300970077515,,2.5305846855490555,,2.3557323427745276,,Uncertain,Uncertain,,Uncertain,0.2702849344532587,,0.34694449691547086,0.62379,,2.0072334395670537,,1.3155117197835269,,Uncertain,,Neutral,,0.7404498924281488,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,neutral,,-0.3541,1.041,-22.2273,-5.24287573150059,0.7432071545088421,Pathogenic,0.917,pathogenic,-4.077,available,https://doi.org/10.1101/2022.10.22.513328 +L264T,NP_000537:p.Leu264Thr,,,,,saturation_mutlist,,,,,,,,1.37305,1.2051804947853089,,1.8578264888961435,,1.6154382444480717,,Neutral,Uncertain,,Neutral,0.3094973924446164,,0.23310236599538628,0.78784,,1.6651710484157078,,1.226505524207854,,Neutral,,Neutral,,0.6867698726653576,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,neutral,,-0.259,1.041,-8.9394,-3.82161584058167,0.0819531147275861,Benign,0.583,pathogenic,-3.621,available,https://doi.org/10.1101/2022.10.22.513328 +L264V,NP_000537:p.Leu264Val,"hg19,17:g.7577148G>C, hg38,17:g.7673830G>C",,,0.381,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,1.30208,0.30014466285705566,0.24206333333333338,0.8284199940702535,0.7720716666666666,1.0652499970351266,Neutral,Neutral,Neutral,Neutral,Neutral,0.3141030740637625,0.4441103677640903,0.11002383603181483,0.68414,0.05838999999999998,1.111664604068757,0.37126499999999996,0.8979023020343785,Neutral,Neutral,Neutral,Neutral,0.3378647591369462,0.3982179731940254,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,neutral,,-0.1233,1.041,-0.5217,-0.402437184412507,3.577275405634069e-07,Benign,0.0848,benign,-2.988,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L264W,NP_000537:p.Leu264Trp,,,,,saturation_mutlist,,,,,,,,1.84449,1.1927333283424377,,0.7469834388639377,,1.2957367194319689,,Neutral,Uncertain,,Neutral,0.3104323418738163,,0.2882346240945695,3.10203,,0.6532974410575555,,1.8776637205287778,,Uncertain,,Neutral,,0.9662967394370829,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,uncertain,,-0.3563,1.041,-22.2273,-6.5461871813981,0.8021018762609149,Pathogenic,0.9282,pathogenic,-4.365,available,https://doi.org/10.1101/2022.10.22.513328 +L264Y,NP_000537:p.Leu264Tyr,,,,,saturation_mutlist,,,,,,,,1.55713,1.3174779081344605,,1.1036417130391476,,1.3303858565195736,,Neutral,Uncertain,,Neutral,0.3069917026251308,,0.4064576601310146,1.22723,,0.9965219218325809,,1.1118759609162905,,Neutral,,Neutral,,0.8948847315685984,39.531,4.872,38.29,20.23,,False,39.531,,neutral,neutral,neutral,,False,38.29,,neutral,neutral,neutral,uncertain,,-0.3492,1.041,-22.2273,-6.5461871813981,0.8052134654630674,Pathogenic,0.9439,pathogenic,-4.32,available,https://doi.org/10.1101/2022.10.22.513328 +L265A,NP_000537:p.Leu265Ala,,,,,saturation_mutlist,,,,,,,,2.30633,2.2305146408081056,,2.2964287704183763,,2.301379385209188,,Uncertain,Destabilizing,,Uncertain,0.2629178975692772,,0.31889666474934614,0.3097,,1.6614166085037436,,0.9855583042518719,,Neutral,,Neutral,,0.41141535204823027,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.4156,0.0422,-22.2332,-7.34723861280443,0.8707259869926334,Pathogenic,0.8985,pathogenic,-4.486,available,https://doi.org/10.1101/2022.10.22.513328 +L265C,NP_000537:p.Leu265Cys,,,,,saturation_mutlist,,,,,,,,2.19289,1.5030040693283082,,2.4857507018717846,,2.339320350935892,,Uncertain,Uncertain,,Uncertain,0.1755767279279987,,0.2458139257589205,0.34811,,2.038541756619288,,1.193325878309644,,Uncertain,,Neutral,,0.2962671820206014,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.4048,0.0422,-22.2332,-7.34723861280443,0.7752014848127868,Pathogenic,0.9147,pathogenic,-4.28,available,https://doi.org/10.1101/2022.10.22.513328 +L265D,NP_000537:p.Leu265Asp,,,,,saturation_mutlist,,,,,,,,2.67085,2.5028103494644167,,2.8624895313280057,,2.7666697656640027,,Uncertain,Destabilizing,,Uncertain,0.3020009767424982,,0.3036975412956689,0.72947,,1.7091172204964635,,1.2192936102482317,,Neutral,,Neutral,,0.36626221126617015,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.5371,0.0422,-22.2332,-7.87558311971445,0.860964696318212,Pathogenic,0.9979,pathogenic,-4.85,available,https://doi.org/10.1101/2022.10.22.513328 +L265E,NP_000537:p.Leu265Glu,,,,,saturation_mutlist,,,,,,,,2.12508,2.5222350025177,,2.4578181408694544,,2.2914490704347275,,Uncertain,Destabilizing,,Uncertain,0.2819575775258251,,0.2905795982704159,0.94247,,1.4363809183035974,,1.1894254591517988,,Neutral,,Neutral,,0.3085380650372369,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.5052,0.0422,-22.2332,-7.87558311971445,0.8589987811206987,Pathogenic,0.9814,pathogenic,-4.684,available,https://doi.org/10.1101/2022.10.22.513328 +L265F,NP_000537:p.Leu265Phe,,,,,saturation_mutlist,,,,,,,,0.27184,1.3308099842071532,,0.63282224227746,,0.45233112113873,,Neutral,Uncertain,,Neutral,0.4538599040094546,,0.2922510617845518,0.48594,,0.6554545424231816,,0.5706972712115908,,Neutral,,Neutral,,0.22693180696004925,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.3491,0.0422,-22.2332,-6.34314312364686,0.7726812077242147,Pathogenic,0.6692,pathogenic,-4.072,available,https://doi.org/10.1101/2022.10.22.513328 +L265G,NP_000537:p.Leu265Gly,,,,,saturation_mutlist,,,,,,,,3.09857,3.0470030021667482,,3.4789264210122055,,3.2887482105061028,,Destabilizing,Destabilizing,,Destabilizing,0.3295849398958595,,0.6165865302415637,0.11635,,2.5776996328407114,,1.3470248164203558,,Uncertain,,Neutral,,0.5010382695075117,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.4904,0.0422,-22.2332,-7.87558311971445,0.8517707979603193,Pathogenic,0.9901,pathogenic,-4.767,available,https://doi.org/10.1101/2022.10.22.513328 +L265H,NP_000537:p.Leu265His,,,,,saturation_mutlist,,,,,,,,1.96658,2.197988119125366,,1.6315706369449938,,1.799075318472497,,Neutral,Destabilizing,,Neutral,0.3397668380549775,,0.15479755509080095,1.02992,,1.0581395855249642,,1.044029792762482,,Neutral,,Neutral,,0.2894609019985907,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.458,0.0422,-22.2332,-6.61671431671546,0.590477952725514,Uncertain,0.9292,pathogenic,-4.209,available,https://doi.org/10.1101/2022.10.22.513328 +L265I,NP_000537:p.Leu265Ile,,,,,saturation_mutlist,,,,,,,,0.9983,0.8135057210922241,,1.2709733819967484,,1.134636690998374,,Neutral,Neutral,,Neutral,0.26416727652271654,,0.14843200037637316,0.21562,,0.6450470414847191,,0.4303335207423596,,Neutral,,Neutral,,0.23922781009366811,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,uncertain,,-0.2219,0.0422,-8.9453,-3.83204599167508,0.0687300349208046,Benign,0.2627,benign,-3.624,available,https://doi.org/10.1101/2022.10.22.513328 +L265K,NP_000537:p.Leu265Lys,,,,,saturation_mutlist,,,,,,,,0.98983,2.1978190469741823,,2.221696619669658,,1.605763309834829,,Uncertain,Destabilizing,,Neutral,0.1945457894561941,,0.49169949442725747,0.19942,,1.3802715651779203,,0.7898457825889601,,Neutral,,Neutral,,0.43186399281615817,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,uncertain,,-0.5042,0.0422,-22.2332,-7.61141086625944,0.8702665156745051,Pathogenic,0.9454,pathogenic,-4.58,available,https://doi.org/10.1101/2022.10.22.513328 +L265M,NP_000537:p.Leu265Met,"hg38,17:g.7673827G>T",,,0.870,"COSMIC,saturation_mutlist",,,,,,,,-0.0521,0.8894155693054199,1.4125866666666667,1.2528505472534206,0.6802433333333333,0.6003752736267103,Neutral,Neutral,Neutral,Neutral,Neutral,0.22589375790025543,0.3584303953194942,0.09678339760547154,-0.23359,0.5114533333333333,0.9203840553678203,0.13893166666666668,0.34339702768391017,Neutral,Neutral,Neutral,Neutral,0.1754870161072386,0.24987763379293504,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,uncertain,,-0.313,0.0422,-22.2332,-3.91495728915611,0.7528596764569417,Pathogenic,0.4348,ambiguous,-3.942,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L265N,NP_000537:p.Leu265Asn,,,,,saturation_mutlist,,,,,,,,2.40954,2.5432294273376463,,2.203860928677375,,2.3067004643386877,,Uncertain,Destabilizing,,Uncertain,0.2251074560552595,,0.32935399229161805,0.40717,,1.491285577057995,,0.9492277885289975,,Neutral,,Neutral,,0.35002996226400945,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.4834,0.0422,-22.2332,-7.87558311971445,0.8671597521678513,Pathogenic,0.9905,pathogenic,-4.724,available,https://doi.org/10.1101/2022.10.22.513328 +L265P,NP_000537:p.Leu265Pro,"hg19,17:g.7577143_7577144delinsAG, hg19,17:g.7577144A>G, hg19,17:g.7673826A>G, hg38,17:g.7673825_7673826delinsAG, hg38,17:g.7673826A>G",,,0.948,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",245777,Pathogenic/Likely pathogenic,2,,,,,5.47796,2.843164472579956,6.904986666666666,7.049176755660981,6.191473333333333,6.263568377830491,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.3204207483238897,0.6603496470978253,0.1757183516314385,3.25636,3.53016,4.514245887882353,3.3932599999999997,3.8853029439411766,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.8618466897308362,0.38596764872311623,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.499,0.0422,-22.2332,-7.87558311971445,0.8656403829284776,Pathogenic,0.9913,pathogenic,-4.572,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L265Q,NP_000537:p.Leu265Gln,"hg19,17:g.7577144A>T, hg19,17:g.7673826A>T, hg38,17:g.7673826A>T",,,0.964,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",953467,Pathogenic/Likely pathogenic,2,,,,,1.76748,2.241291198730469,1.2387766666666666,1.9919460365220705,1.5031283333333332,1.879713018261035,Neutral,Neutral,Destabilizing,Neutral,Neutral,0.28928559491293687,0.6012946256388978,0.28138251103518513,0.31875,1.1439933333333334,1.4627199448921129,0.7313716666666668,0.8907349724460565,Neutral,Neutral,Neutral,Neutral,0.2534229669062288,0.31305805238979756,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.4364,0.0422,-22.2332,-7.87558311971445,0.8682348257349046,Pathogenic,0.9105,pathogenic,-4.315,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L265R,NP_000537:p.Leu265Arg,"hg19,17:g.7577144A>C, hg19,17:g.7673826A>C, hg38,17:g.7673826A>C",,,0.965,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2764543,Uncertain significance,1,Likely oncogenic,1,,,1.36805,2.1160898876190184,2.1888866666666664,1.5711809435644322,1.778468333333333,1.469615471782216,Uncertain,Neutral,Destabilizing,Neutral,Neutral,0.20082973212686742,0.11960239973437921,0.39214204435879585,0.58308,1.7589566666666665,0.9911678682950779,1.1710183333333333,0.7871239341475389,Neutral,Neutral,Neutral,Neutral,0.6151478106565571,0.39124174071101847,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.4958,0.0422,-22.2332,-7.37297889237968,0.8695697876898334,Pathogenic,0.8691,pathogenic,-4.334,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L265S,NP_000537:p.Leu265Ser,,,,,saturation_mutlist,,,,,,,,2.82359,2.5824453163146974,,2.941014976145706,,2.882302488072853,,Uncertain,Destabilizing,,Uncertain,0.24123056825443792,,0.36156194525655705,0.43005,,1.8827530643430765,,1.1564015321715382,,Neutral,,Neutral,,0.40833659269664946,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.446,0.0422,-22.2332,-6.75359307517743,0.8708271923916435,Pathogenic,0.981,pathogenic,-4.464,available,https://doi.org/10.1101/2022.10.22.513328 +L265T,NP_000537:p.Leu265Thr,"hg19,17:g.7577144_7577145delinsGT",,,,"cBioPortal,saturation_mutlist",,,,,,,,3.07001,2.3499163293838503,2.5365066666666665,2.404262187776347,2.803258333333333,2.7371360938881732,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,0.2566771061363745,0.12576434824261168,0.2027759652861047,0.75477,1.396823333333333,1.4514847743121642,1.0757966666666665,1.103127387156082,Neutral,Neutral,Neutral,Neutral,0.2855564038076463,0.26303082360036234,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.4187,0.0422,-22.2332,-7.34723861280443,0.8694242445775713,Pathogenic,0.9283,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L265V,NP_000537:p.Leu265Val,,,,,saturation_mutlist,,,,,,,,1.79164,1.5713572931289672,2.1557833333333334,1.528068636566865,1.9737116666666665,1.6598543182834324,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.24890187078522524,1.163057008013317,0.1352277823926714,0.31516,0.69195,0.8673192360831062,0.503555,0.5912396180415531,Neutral,Neutral,Neutral,Neutral,0.7069066837049051,0.14477186732845493,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.2582,0.0422,-8.9453,-3.77375082373062,0.1106420172817101,Benign,0.3252,benign,-3.641,available,https://doi.org/10.1101/2022.10.22.513328 +L265W,NP_000537:p.Leu265Trp,,,,,saturation_mutlist,,,,,,,,1.23031,1.6341945695877076,,0.7521392180179282,,0.991224609008964,,Neutral,Uncertain,,Neutral,0.35865086657692635,,0.19456996736094095,1.61243,,0.39890957835444607,,1.005669789177223,,Neutral,,Neutral,,0.18566823151793677,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.4482,0.0422,-22.2332,-6.84349102707037,0.8235872876217347,Pathogenic,0.8178,pathogenic,-4.396,available,https://doi.org/10.1101/2022.10.22.513328 +L265Y,NP_000537:p.Leu265Tyr,,,,,saturation_mutlist,,,,,,,,0.46027,1.5908128118515015,,0.9615430520059273,,0.7109065260029637,,Neutral,Uncertain,,Neutral,0.45934394491166913,,0.2148685206487366,0.91275,,0.7929398205163429,,0.8528449102581714,,Neutral,,Neutral,,0.25481511500060927,17.835,4.577,27.57,17.594,,False,17.835,,neutral,neutral,neutral,,False,27.57,,neutral,neutral,neutral,neutral,,-0.4411,0.0422,-22.2332,-5.86744239818955,0.6527592081560019,Uncertain,0.8938,pathogenic,-4.002,available,https://doi.org/10.1101/2022.10.22.513328 +G266A,NP_000537:p.Gly266Ala,"hg19,17:g.7577141C>G, hg38,17:g.7673823C>G",,,0.960,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,3.11904,1.4215033912658692,1.1027233333333333,0.6373954717422299,2.1108816666666668,1.878217735871115,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,0.49434680847732243,1.5154633523630836,0.8549096722288718,3.15757,1.81905,1.2196927453800053,2.4883100000000002,2.188631372690003,Uncertain,Uncertain,Uncertain,Uncertain,3.8366546340877057,0.19438606318767604,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.31,0.0633,-8.9453,-6.36324581472309,0.012636196124792,Benign,0.8482,pathogenic,-3.668,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266C,NP_000537:p.Gly266Cys,,,,,saturation_mutlist,,,,,,,,6.18109,1.4521881866455078,,2.0129925159133775,,4.097041257956689,,Uncertain,Uncertain,,Destabilizing,0.275861418767228,,1.220997926429273,5.24128,,2.483056200941697,,3.862168100470848,,Uncertain,,Destabilizing,,0.5318349567872541,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4376,0.0633,-22.2332,-6.93805310884829,0.8691672870950153,Pathogenic,0.9857,pathogenic,-4.429,available,https://doi.org/10.1101/2022.10.22.513328 +G266D,NP_000537:p.Gly266Asp,,,,,saturation_mutlist,,,,,,,,13.11678,2.548125762939453,,3.6791855985121686,,8.397982799256084,,Destabilizing,Destabilizing,,Destabilizing,0.26118967138872984,,1.3334157121837265,10.06858,,4.032864195232577,,7.050722097616289,,Destabilizing,,Destabilizing,,0.7246610883805475,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4381,0.0633,-22.2332,-6.77792298967897,0.804870665107659,Pathogenic,0.9976,pathogenic,-4.211,available,https://doi.org/10.1101/2022.10.22.513328 +G266E,NP_000537:p.Gly266Glu,"hg19,17:g.7577141C>T, hg19,17:g.7673823C>T, hg38,17:g.7673823C>T",,,0.973,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",161516,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier II - Potential,1,12.49978,2.5784941482543946,11.30964,4.752797249720208,11.90471,8.626288624860104,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.23514309998718444,1.9268493809498106,1.418410921318165,12.54354,9.897503333333335,4.84357962012049,11.220521666666667,8.693559810060245,Destabilizing,Destabilizing,Destabilizing,Destabilizing,5.532982205431555,1.0676075757271715,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.3696,0.0633,-8.9453,-7.46706303705164,0.8706355278571457,Pathogenic,0.9988,pathogenic,-4.432,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266F,NP_000537:p.Gly266Phe,,,,,saturation_mutlist,,,,,,,,24.24892,1.3070175051689148,,3.1445462502866035,,13.6967331251433,,Destabilizing,Uncertain,,Destabilizing,0.2670380271029326,,1.5100516440255607,27.97991,,3.9827323649922053,,15.981321182496103,,Destabilizing,,Destabilizing,,1.2887447459641106,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4757,0.0633,-22.2332,-7.88629348640739,0.8701221009629496,Pathogenic,0.9979,pathogenic,-4.817,available,https://doi.org/10.1101/2022.10.22.513328 +G266H,NP_000537:p.Gly266His,,,,,saturation_mutlist,,,,,,,,21.34854,2.165183730125427,,3.725478356624459,,12.53700917831223,,Destabilizing,Destabilizing,,Destabilizing,0.2422703807942632,,1.3979806440306815,23.79181,,4.266142773690056,,14.028976386845029,,Destabilizing,,Destabilizing,,1.071998225627579,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4504,0.0633,-22.2332,-7.88629348640739,0.8708218989973193,Pathogenic,0.9995,pathogenic,-4.688,available,https://doi.org/10.1101/2022.10.22.513328 +G266I,NP_000537:p.Gly266Ile,,,,,saturation_mutlist,,,,,,,,13.32832,1.7645795106887818,,4.640300440398076,,8.984310220199038,,Destabilizing,Uncertain,,Destabilizing,0.31387534804204786,,1.6151351351429823,12.28587,,4.505089715434122,,8.39547985771706,,Destabilizing,,Destabilizing,,1.4720604064421918,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.5213,0.0633,-22.2332,-7.88629348640739,0.8707945277384153,Pathogenic,0.9983,pathogenic,-4.824,available,https://doi.org/10.1101/2022.10.22.513328 +G266K,NP_000537:p.Gly266Lys,"hg19,17:g.7577141_7577142delinsTT, hg38,17:g.7673823_7673824delinsTT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,16.29781,2.3671384477615356,18.09523666666667,5.787491851954907,17.19652333333333,11.042650925977453,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.3034494749788079,3.342356406492615,1.4454668510781181,16.54971,12.256806666666668,6.0653823571429575,14.403258333333333,11.30754617857148,Destabilizing,Destabilizing,Destabilizing,Destabilizing,1.2144936441259062,0.8297992724267395,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4703,0.0633,-22.2332,-7.88629348640739,0.8707875146213229,Pathogenic,0.9995,pathogenic,-4.696,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266L,NP_000537:p.Gly266Leu,"hg38,17:g.7673823_7673824delinsAA",,,,"COSMIC,saturation_mutlist",,,,,,,,13.92146,1.9180930614471436,,3.2813331111628443,,8.601396555581422,,Destabilizing,Uncertain,,Destabilizing,0.20718257868203604,,1.4139067416298015,12.4033,,3.3354322619427514,,7.869366130971375,,Destabilizing,,Destabilizing,,1.2814303639987952,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4896,0.0633,-22.2332,-7.88629348640739,0.8706234257673205,Pathogenic,0.9963,pathogenic,-4.708,available,https://doi.org/10.1101/2022.10.22.513328 +G266M,NP_000537:p.Gly266Met,,,,,saturation_mutlist,,,,,,,,9.70774,1.7861678791046143,,3.0561874447675526,,6.381963722383776,,Destabilizing,Uncertain,,Destabilizing,0.23540253696787097,,1.301592024964422,11.22287,,3.5578160097606624,,7.390343004880331,,Destabilizing,,Destabilizing,,1.011714974546127,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4278,0.0633,-22.2332,-7.88629348640739,0.8708636637510747,Pathogenic,0.9989,pathogenic,-4.8,available,https://doi.org/10.1101/2022.10.22.513328 +G266N,NP_000537:p.Gly266Asn,,,,,saturation_mutlist,,,,,,,,12.06805,2.4249103927612303,,2.7016518480303535,,7.3848509240151765,,Uncertain,Destabilizing,,Destabilizing,0.24138225185673,,1.2351806169178052,9.06539,,2.905498977297938,,5.9854444886489695,,Uncertain,,Destabilizing,,0.7061754007586435,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4384,0.0633,-22.2332,-7.46706303705164,0.8705798072697052,Pathogenic,0.9992,pathogenic,-4.65,available,https://doi.org/10.1101/2022.10.22.513328 +G266P,NP_000537:p.Gly266Pro,,,,,saturation_mutlist,,,,,,,,9.77407,2.07666841506958,,7.933066951428594,,8.853568475714297,,Destabilizing,Destabilizing,,Destabilizing,0.25684712727165443,,0.9894338492000685,7.90804,,8.516631949007945,,8.212335974503972,,Destabilizing,,Destabilizing,,0.5522033841577705,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4677,0.0633,-8.9453,-7.88629348640739,0.8699137131956447,Pathogenic,0.9995,pathogenic,-4.68,available,https://doi.org/10.1101/2022.10.22.513328 +G266Q,NP_000537:p.Gly266Gln,,,,,saturation_mutlist,,,,,,,,13.19018,2.3203052186965945,,3.734703651032028,,8.462441825516013,,Destabilizing,Destabilizing,,Destabilizing,0.2606639879405007,,1.5165415869659504,13.13311,,4.185930486222083,,8.659520243111041,,Destabilizing,,Destabilizing,,1.0160486132654434,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4413,0.0633,-22.2332,-7.46706303705164,0.8678472978241196,Pathogenic,0.9987,pathogenic,-4.703,available,https://doi.org/10.1101/2022.10.22.513328 +G266R,NP_000537:p.Gly266Arg,"hg19,17:g.7577142C>G, hg19,17:g.7577142C>T, hg19,17:g.7577142_7577143delinsTT, hg19,17:g.7673824C>G, hg19,17:g.7673824C>T, hg38,17:g.7673824C>G, hg38,17:g.7673824C>T, hg38,17:g.7673824_7673825delinsTT",,,0.963,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","458566, 376605","Pathogenic, Pathogenic","2, 2",Oncogenic,1,,,20.20804,2.1415745210647583,15.434803333333335,4.90518932100621,17.821421666666666,12.556614660503104,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.3118433345348797,1.8658049941394084,1.4486457015632392,20.01615,10.726643333333334,5.2913550119901975,15.371396666666666,12.653752505995099,Destabilizing,Destabilizing,Destabilizing,Destabilizing,1.7359317171158806,0.9449591619327204,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4544,0.0633,-22.2332,-7.88629348640739,0.8585408758137115,Pathogenic,0.9986,pathogenic,-4.518,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266S,NP_000537:p.Gly266Ser,,,,,"COSMIC,saturation_mutlist",,,,,,,,4.77076,1.8808586835861205,3.2281166666666667,1.953434764512097,3.9994383333333334,3.3620973822560485,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.42902155507114437,1.1943594122745838,1.0817863255348044,4.68254,3.4498866666666674,2.4059027454739383,4.066213333333334,3.5442213727369696,Destabilizing,Uncertain,Destabilizing,Destabilizing,3.3025491156613485,0.25634497520009714,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.3837,0.0633,-22.2332,-6.93805310884829,0.8684281199810319,Pathogenic,0.9729,pathogenic,-4.17,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266T,NP_000537:p.Gly266Thr,"hg19,17:g.7577141_7577142delinsGT, hg38,17:g.7673823_7673824delinsGT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,9.69534,2.028735752105713,5.936963333333334,2.860818547193238,7.816151666666666,6.278079273596619,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,0.41951874320684734,1.3040005499061553,1.4394120758288937,8.79749,6.897846666666667,3.2875701245186453,7.847668333333333,6.042530062259322,Destabilizing,Destabilizing,Destabilizing,Destabilizing,5.447010917597121,0.7112382887309685,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4606,0.0633,-22.2332,-6.93805310884829,0.8675692223173517,Pathogenic,0.9969,pathogenic,-4.639,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266V,NP_000537:p.Gly266Val,"hg19,17:g.7577141C>A, hg19,17:g.7673823C>A, hg38,17:g.7673823C>A",,0.0,0.974,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",233303,Conflicting classifications of pathogenicity,1,,,,,10.74834,1.6596538257598876,10.074376666666668,3.6071465816925006,10.411358333333334,7.177743290846251,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.322890198917074,2.9902837781202116,1.6594118650207457,9.67364,7.278343333333333,3.435835676253617,8.475991666666667,6.554737838126809,Destabilizing,Destabilizing,Destabilizing,Destabilizing,4.633228764927926,1.1881156416835648,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4646,0.0633,-22.2332,-7.88629348640739,0.8707030325359331,Pathogenic,0.9956,pathogenic,-4.654,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266W,NP_000537:p.Gly266Trp,,,,,saturation_mutlist,,,,,,,,35.83829,1.4300118899345398,,4.138207114668988,,19.988248557334494,,Destabilizing,Uncertain,,Destabilizing,0.2790185646029319,,1.3384664425177588,38.78697,,4.927937344715346,,21.85745367235767,,Destabilizing,,Destabilizing,,0.8610478552722324,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4754,0.0633,-22.2332,-7.88629348640739,0.8586158067431862,Pathogenic,0.9978,pathogenic,-4.717,available,https://doi.org/10.1101/2022.10.22.513328 +G266Y,NP_000537:p.Gly266Tyr,,,,,saturation_mutlist,,,,,,,,29.14401,1.5180719804763794,,3.8526415087866455,,16.498325754393324,,Destabilizing,Uncertain,,Destabilizing,0.2535353292126201,,1.4996153227203526,31.41779,,4.819578800040152,,18.118684400020076,,Destabilizing,,Destabilizing,,1.1712975165783233,0.039,0.286,0.22,0.437,,False,0.039,,neutral,neutral,neutral,,False,0.22,,neutral,neutral,neutral,neutral,,-0.4761,0.0633,-22.2332,-7.88629348640739,0.8705950513473898,Pathogenic,0.9981,pathogenic,-4.773,available,https://doi.org/10.1101/2022.10.22.513328 +R267A,NP_000537:p.Arg267Ala,,,,,saturation_mutlist,,,,,,,,1.58242,1.253767855167389,,1.5444924573838705,,1.5634562286919351,,Neutral,Uncertain,,Neutral,0.3020013747603745,,0.18031872781784272,-0.20908,,1.7343760292487909,,0.7626480146243955,,Neutral,,Neutral,,0.1427772102630729,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.3984,0.1239,-22.2332,-7.70598599850712,0.763277557069098,Pathogenic,0.9968,pathogenic,-4.405,available,https://doi.org/10.1101/2022.10.22.513328 +R267C,NP_000537:p.Arg267Cys,,,,,saturation_mutlist,,,,,,,,1.02652,0.9083309626579285,,2.1375461466884866,,1.5820330733442434,,Uncertain,Neutral,,Neutral,0.36083095683376265,,0.11787497690141571,-0.63595,,2.0236472424175957,,0.6938486212087979,,Uncertain,,Neutral,,0.1741416647500175,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.4073,0.1239,-22.2332,-7.70598599850712,0.7270433074700877,Pathogenic,0.9269,pathogenic,-4.082,available,https://doi.org/10.1101/2022.10.22.513328 +R267D,NP_000537:p.Arg267Asp,,,,,saturation_mutlist,,,,,,,,2.2361,2.5933684062957765,,2.7338694757821393,,2.48498473789107,,Uncertain,Destabilizing,,Uncertain,0.4379382750518278,,0.1417632724093637,1.60702,,2.8619929286756354,,2.2345064643378176,,Uncertain,,Uncertain,,0.47928552717237877,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.4895,0.1239,-22.2332,-7.03787472762136,0.8122861587131511,Pathogenic,0.9988,pathogenic,-4.59,available,https://doi.org/10.1101/2022.10.22.513328 +R267E,NP_000537:p.Arg267Glu,,,,,saturation_mutlist,,,,,,,,1.74693,1.7680546617507935,,2.0889654760045846,,1.9179477380022925,,Uncertain,Uncertain,,Neutral,0.3066020529298693,,0.12962953738875574,0.81259,,2.297814592777901,,1.5552022963889505,,Uncertain,,Neutral,,0.44679069444900704,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.4347,0.1239,-22.2332,-7.03787472762136,0.7954748457581995,Pathogenic,0.9861,pathogenic,-4.448,available,https://doi.org/10.1101/2022.10.22.513328 +R267F,NP_000537:p.Arg267Phe,,,,,saturation_mutlist,,,,,,,,5.10186,0.6581262969970703,,0.8312939520212291,,2.966576976010615,,Uncertain,Neutral,,Uncertain,0.2893197421019212,,0.18320414963469833,1.15152,,0.695257418079882,,0.9233887090399411,,Neutral,,Neutral,,0.10624379086174494,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,neutral,,-0.4306,0.1239,-22.2332,-6.77941400693417,0.7268613507697419,Pathogenic,0.9982,pathogenic,-4.458,available,https://doi.org/10.1101/2022.10.22.513328 +R267G,NP_000537:p.Arg267Gly,"hg19,17:g.7577139G>C, hg19,17:g.7673821G>C, hg38,17:g.7673821G>C",,,0.946,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1761541,Pathogenic,2,,,Tier I - Strong,1,2.67801,2.053549952507019,2.9965999999999995,2.947704096737761,2.8373049999999997,2.8128570483688806,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,0.31569152303487236,0.18018150349023074,0.2466134161116277,0.49943,1.3827666666666667,3.1616786741058434,0.9410983333333334,1.8305543370529216,Neutral,Uncertain,Neutral,Neutral,0.3611141040662294,0.4022078800654583,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.4338,0.1239,-22.2332,-7.70598599850712,0.7307094535702936,Pathogenic,0.9913,pathogenic,-4.378,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R267H,NP_000537:p.Arg267His,,,,,saturation_mutlist,,,,,,,,4.04824,1.47654541015625,,1.4901813437256823,,2.769210671862841,,Uncertain,Uncertain,,Uncertain,0.2505649564522992,,0.12305386932638555,2.59084,,1.3630790800760266,,1.9769595400380133,,Uncertain,,Neutral,,0.3826844390121091,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.2885,0.1239,-6.6235,-3.9168867483715,0.0011584855650976,Benign,0.928,pathogenic,-3.609,available,https://doi.org/10.1101/2022.10.22.513328 +R267I,NP_000537:p.Arg267Ile,,,,,saturation_mutlist,,,,,,,,0.88662,0.3069217538833618,,0.5533277864299523,,0.7199738932149762,,Neutral,Neutral,,Neutral,0.5161762871920097,,0.22539816106604985,-0.4058,,0.4603700368682833,,0.02728501843414166,,Neutral,,Neutral,,0.23438659756591063,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.4279,0.1239,-22.2332,-7.44752527781993,0.4627388881602232,Uncertain,0.9929,pathogenic,-4.459,available,https://doi.org/10.1101/2022.10.22.513328 +R267K,NP_000537:p.Arg267Lys,,,,,saturation_mutlist,,,,,,,,0.35247,0.44648621320724485,,1.5523394145970453,,0.9524047072985227,,Neutral,Neutral,,Neutral,0.08787846605806207,,0.1952833291718579,-0.43639,,1.7946439564377623,,0.6791269782188811,,Neutral,,Neutral,,0.48465701895403773,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.2887,0.1239,-22.2332,-3.78185491236608,0.6437276333224374,Uncertain,0.9118,pathogenic,-3.914,available,https://doi.org/10.1101/2022.10.22.513328 +R267L,NP_000537:p.Arg267Leu,"hg19,17:g.7577137_7577138delinsAA, hg19,17:g.7577138C>A, hg19,17:g.7673820C>A, hg38,17:g.7673819_7673820delinsAA, hg38,17:g.7673820C>A",,,0.911,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",852206,Uncertain significance,2,,,,,-0.36522,0.5373617815971374,-0.18616666666666667,0.4556080523406983,-0.27569333333333335,0.04519402617034915,Neutral,Neutral,Neutral,Neutral,Neutral,0.4874052003799496,0.46581237455534485,0.19866927882951144,-1.52455,-1.3350366666666666,0.09709755493105705,-1.4297933333333335,-0.7137262225344715,Neutral,Neutral,Neutral,Neutral,0.6734471959668074,0.08596922472237355,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.4009,0.1239,-22.2332,-4.27853092395634,0.7874690055118875,Pathogenic,0.9887,pathogenic,-4.313,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R267M,NP_000537:p.Arg267Met,,,,,saturation_mutlist,,,,,,,,-0.36458,0.47616360664367674,,1.0075657658934896,,0.3214928829467448,,Neutral,Neutral,,Neutral,0.32149221448976556,,0.16052231769657047,-1.8561,,0.6667441947431976,,-0.5946779026284013,,Neutral,,Neutral,,0.01308367772876444,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.3667,0.1239,-22.2332,-7.44752527781993,0.8148616754695868,Pathogenic,0.9967,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328 +R267N,NP_000537:p.Arg267Asn,,,,,saturation_mutlist,,,,,,,,1.31425,1.911297197341919,,1.8946742196709827,,1.6044621098354912,,Neutral,Uncertain,,Neutral,0.3615022328940192,,0.17416551596416927,0.59817,,1.7257346360720238,,1.1619523180360118,,Neutral,,Neutral,,0.16510180353885198,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.4133,0.1239,-22.2332,-7.03787472762136,0.7864307798303529,Pathogenic,0.9977,pathogenic,-4.465,available,https://doi.org/10.1101/2022.10.22.513328 +R267P,NP_000537:p.Arg267Pro,"hg19,17:g.7577137_7577138delinsGG, hg19,17:g.7577138C>G, hg19,17:g.7673820C>G, hg38,17:g.7673819_7673820inv, hg38,17:g.7673820C>G",,,0.927,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428867,Conflicting classifications of pathogenicity,1,,,,,6.22844,1.972615556716919,7.366103333333332,5.652089243245558,6.797271666666666,5.940264621622779,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.394524348670686,0.5524287043793272,0.5519216970349913,4.2621,6.312016666666666,6.008085264253805,5.2870583333333325,5.135092632126902,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.6756990939924534,1.246931081273858,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.5405,0.1239,-22.2332,-7.70598599850712,0.7564408251132462,Pathogenic,0.9992,pathogenic,-4.476,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R267Q,NP_000537:p.Arg267Gln,"hg19,17:g.7577138C>T, hg19,17:g.7673820C>T, hg38,17:g.7673820C>T",,1.2030991835e-05,0.902,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127823,Likely pathogenic,3,Uncertain significance,1,,,0.83869,1.015028214454651,0.04988666666666666,1.6517815322439109,0.44428833333333334,1.2452357661219555,Neutral,Neutral,Uncertain,Neutral,Neutral,0.2823310236994966,0.1122882295206799,0.11935162429177348,-0.03852,-0.6947833333333332,1.616361374634703,-0.3666516666666666,0.7889206873173515,Neutral,Neutral,Neutral,Neutral,0.5261193317954481,0.20055709954746623,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.3732,0.1239,-22.2332,-5.21833867213814,0.0337001581496403,Benign,0.8812,pathogenic,-3.678,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R267S,NP_000537:p.Arg267Ser,,,,,saturation_mutlist,,,,,,,,1.1842,1.1400790739059448,,2.2795902743840113,,1.7318951371920055,,Uncertain,Uncertain,,Neutral,0.39446472608966887,,0.12150842594094978,-0.34449,,2.3829815290242706,,1.0192457645121353,,Uncertain,,Neutral,,0.3072029933762771,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.3312,0.1239,-8.9453,-7.70598599850712,0.0660430118803936,Benign,0.9972,pathogenic,-3.915,available,https://doi.org/10.1101/2022.10.22.513328 +R267T,NP_000537:p.Arg267Thr,,,,,saturation_mutlist,,,,,,,,1.2618,0.689258086681366,,1.5988533561050786,,1.4303266780525394,,Neutral,Neutral,,Neutral,0.4387243610850687,,0.14315625258979514,0.29462,,1.7446444900631572,,1.0196322450315787,,Neutral,,Neutral,,0.2154735023045414,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.4033,0.1239,-22.2332,-7.70598599850712,0.8209365269197904,Pathogenic,0.9958,pathogenic,-4.21,available,https://doi.org/10.1101/2022.10.22.513328 +R267V,NP_000537:p.Arg267Val,,,,,saturation_mutlist,,,,,,,,1.18312,0.35445335388183596,,0.7691902950622107,,0.9761551475311053,,Neutral,Neutral,,Neutral,0.5051795085610459,,0.2078693031103322,-0.12496,,0.6654245447425032,,0.27023227237125164,,Neutral,,Neutral,,0.30785922240322666,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,uncertain,,-0.4149,0.1239,-22.2332,-7.44752527781993,0.7674434817242352,Pathogenic,0.9923,pathogenic,-4.338,available,https://doi.org/10.1101/2022.10.22.513328 +R267W,NP_000537:p.Arg267Trp,"hg19,17:g.7577139G>A, hg19,17:g.7673821G>A, hg38,17:g.7673821G>A",,0.0,0.917,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141764,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,Tier I - Strong,1,6.3241,0.8646254110336303,2.076756666666667,0.666587522635219,4.200428333333333,3.4953437613176095,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,0.3620082309931772,1.3020516170089247,0.2441203736403121,2.66191,0.24943666666666675,0.5210354757399145,1.4556733333333334,1.5914727378699574,Uncertain,Uncertain,Neutral,Neutral,2.184243913445159,0.3259707840888104,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,neutral,,-0.3484,0.1239,-8.9453,-6.77941400693417,0.8457833383937833,Pathogenic,0.9682,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R267Y,NP_000537:p.Arg267Tyr,,,,,saturation_mutlist,,,,,,,,7.68761,0.9748883605003357,,1.0741229985938328,,4.380866499296917,,Uncertain,Neutral,,Destabilizing,0.31330171535707113,,0.2001582863551573,2.59767,,0.9695674493547589,,1.7836187246773794,,Uncertain,,Neutral,,0.27662604722393735,15.954,3.322,21.335,6.355,,True,15.954,,neutral,neutral,neutral,,True,21.335,,neutral,neutral,neutral,neutral,,-0.4199,0.1239,-22.2332,-6.77941400693417,0.8028177108850432,Pathogenic,0.992,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328 +N268A,NP_000537:p.Asn268Ala,,,,,saturation_mutlist,,,,,,,,0.81411,-0.01695390582084656,,1.2152289489445387,,1.0146694744722693,,Neutral,Neutral,,Neutral,0.34504658451441844,,0.3719100096587401,-0.54006,,0.5714756060659799,,0.015707803032989964,,Neutral,,Neutral,,0.4351766446905309,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,uncertain,,-0.2294,1.0811,-22.2302,-4.36168635290202,0.0014197097158054,Benign,0.2255,benign,-3.398,available,https://doi.org/10.1101/2022.10.22.513328 +N268C,NP_000537:p.Asn268Cys,,,,,saturation_mutlist,,,,,,,,0.09132,-0.7648204469680786,,1.5191158309076525,,0.8052179154538263,,Neutral,Neutral,,Neutral,0.2997097303217437,,0.23857408393454238,-0.65898,,0.9393193080037441,,0.14016965400187203,,Neutral,,Neutral,,0.35263037143896525,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,uncertain,,-0.2013,1.0811,-6.9425,-2.41546047797844,1.4763222772045958e-07,Benign,0.1827,benign,-3.144,available,https://doi.org/10.1101/2022.10.22.513328 +N268D,NP_000537:p.Asn268Asp,"hg19,17:g.7577136T>C",,,0.221,"cBioPortal,saturation_mutlist",,,,,,,,1.30845,0.17783112227916717,0.13174666666666668,2.2962388850639552,0.7200983333333333,1.8023444425319775,Neutral,Uncertain,Neutral,Neutral,Neutral,0.3142424941933064,0.659545333005161,0.5824079997244374,0.05918,0.12165333333333334,1.563508537274951,0.09041666666666667,0.8113442686374756,Neutral,Neutral,Neutral,Neutral,0.4616202787525214,0.7120271605433065,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,uncertain,,-0.1471,1.0811,-5.4831,-0.591323006675345,1.0104557927148332e-06,Benign,0.0926,benign,-3.234,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N268E,NP_000537:p.Asn268Glu,,,,,saturation_mutlist,,,,,,,,0.60666,0.15335268378257752,,2.017107232910888,,1.311883616455444,,Uncertain,Neutral,,Neutral,0.46413809306560705,,0.5487978653999072,-0.47103,,1.119009620184246,,0.323989810092123,,Neutral,,Neutral,,0.7145115383358811,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,neutral,,-0.2597,1.0811,-22.2302,-4.29554783337864,0.0356002993987211,Benign,0.3838,ambiguous,-3.608,available,https://doi.org/10.1101/2022.10.22.513328 +N268F,NP_000537:p.Asn268Phe,"hg38,17:g.7673817_7673818inv",,,,"COSMIC,saturation_mutlist",,,,,,,,0.14317,-0.15221066594123842,0.04330666666666664,0.339547815748724,0.09323833333333331,0.24135890787436198,Neutral,Neutral,Neutral,Neutral,Neutral,0.47335541905515527,0.907905063037369,0.8999630434551885,-0.50779,0.3924033333333334,-0.3715221604715864,-0.05769333333333329,-0.43965608023579317,Neutral,Neutral,Neutral,Neutral,1.1196554512388572,0.41207125205594536,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,neutral,,-0.2865,1.0811,-22.2302,-4.50942508843303,4.991052092879287e-05,Benign,0.6464,pathogenic,-3.554,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N268G,NP_000537:p.Asn268Gly,,,,,saturation_mutlist,,,,,,,,1.991,0.31464657008647917,,2.9189941238223063,,2.454997061911153,,Uncertain,Neutral,,Uncertain,0.3849709009763039,,0.48946283128042056,0.22531,,2.2399937739054265,,1.2326518869527132,,Uncertain,,Neutral,,0.5709455284534538,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,uncertain,,-0.1843,1.0811,-7.3575,-2.0612816299312,1.3988411064962723e-09,Benign,0.2289,benign,-3.188,available,https://doi.org/10.1101/2022.10.22.513328 +N268H,NP_000537:p.Asn268His,"hg38,17:g.7673818T>G",,,0.404,"COSMIC,saturation_mutlist",,,,,,,,1.50467,0.039258177280426014,0.3283466666666666,1.1388208441987846,0.9165083333333333,1.3217454220993923,Neutral,Neutral,Neutral,Neutral,Neutral,0.3537433696909387,0.3001865615838849,0.7706141499385255,0.87717,1.4842433333333334,0.25391903081368644,1.1807066666666666,0.5655445154068433,Neutral,Neutral,Neutral,Neutral,1.737107451528418,0.4909665209154409,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,neutral,,-0.2344,1.0811,-22.2302,-5.51296298197219,0.0004566673940268,Benign,0.1252,benign,-3.34,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N268I,NP_000537:p.Asn268Ile,"hg19,17:g.7577135T>A, hg19,17:g.7673817T>A, hg38,17:g.7673817T>A",,,0.511,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.97266,-0.14738696694374084,-0.2613366666666666,0.12484379825216124,-0.6169983333333333,-0.4239081008739194,Neutral,Neutral,Neutral,Neutral,Neutral,0.5525364765192803,0.7814333185599112,0.3012462734933914,-1.17025,1.08855,-0.2911925976557043,-0.04085000000000005,-0.7307212988278522,Neutral,Neutral,Neutral,Neutral,1.6313937413144628,0.5309987788584898,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,neutral,,-0.2796,1.0811,-22.2302,-5.43571068450721,0.0068861243844721,Benign,0.4467,ambiguous,-3.855,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N268K,NP_000537:p.Asn268Lys,"hg19,17:g.7577134G>C, hg38,17:g.7673816G>C",,,0.344,"COSMIC,ClinVar,saturation_mutlist",1349719,Conflicting classifications of pathogenicity,1,,,,,0.11923,0.33812214106321337,1.964286666666667,2.0578545504835435,1.0417583333333336,1.0885422752417717,Neutral,Uncertain,Neutral,Neutral,Neutral,0.3704425434351374,0.545404941753271,0.8462478547485532,-0.33727,2.2133766666666665,0.9469365493207121,0.9380533333333333,0.30483327466035604,Uncertain,Neutral,Neutral,Neutral,2.0069001467658745,0.6730487876319485,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,neutral,,-0.2326,1.0811,-22.2302,-2.67496267781037,0.0002191671813352,Benign,0.3993,ambiguous,-3.11,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N268L,NP_000537:p.Asn268Leu,,,,,saturation_mutlist,,,,,,,,-1.08528,-0.4340368390083313,,-0.5106553163960922,,-0.7979676581980462,,Neutral,Neutral,,Neutral,0.38617422671844853,,0.566326007703343,-1.51621,,-0.7751279013709599,,-1.14566895068548,,Neutral,,Neutral,,0.524706228050754,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,neutral,,-0.2861,1.0811,-22.2302,-4.74099025714108,0.0001783843333275,Benign,0.4293,ambiguous,-3.613,available,https://doi.org/10.1101/2022.10.22.513328 +N268M,NP_000537:p.Asn268Met,,,,,saturation_mutlist,,,,,,,,-1.27692,-0.5230368423461914,,0.16817430150265933,,-0.5543728492486704,,Neutral,Neutral,,Neutral,0.4206754732398489,,0.5091965131604529,-1.72336,,-0.2977029415360592,,-1.0105314707680295,,Neutral,,Neutral,,0.5315153390855633,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,neutral,,-0.1673,1.0811,-7.9424,-3.47104308394239,0.0023884216399632,Benign,0.4677,ambiguous,-3.586,available,https://doi.org/10.1101/2022.10.22.513328 +N268P,NP_000537:p.Asn268Pro,,,,,saturation_mutlist,,,,,,,,2.45873,2.413287343978882,,6.430795174810343,,4.4447625874051715,,Uncertain,Destabilizing,,Destabilizing,0.49431254112852824,,0.22330554759067814,1.51483,,5.550933850407682,,3.532881925203841,,Uncertain,,Destabilizing,,0.6540865181486235,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,uncertain,,-0.395,1.0811,-22.2302,-6.37323766412879,0.0528643165791038,Benign,0.9645,pathogenic,-3.827,available,https://doi.org/10.1101/2022.10.22.513328 +N268Q,NP_000537:p.Asn268Gln,,,,,saturation_mutlist,,,,,,,,0.33357,-0.19710878133773804,,1.0262586030516003,,0.6799143015258001,,Neutral,Neutral,,Neutral,0.3999070721293245,,0.47763545288773906,-0.62829,,0.45987602589762916,,-0.08420698705118543,,Neutral,,Neutral,,0.5392137299524645,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,neutral,,-0.1453,1.0811,-6.9425,-2.43363401844085,1.395131926512854e-08,Benign,0.3103,benign,-3.058,available,https://doi.org/10.1101/2022.10.22.513328 +N268R,NP_000537:p.Asn268Arg,,,,,saturation_mutlist,,,,,,,,0.55928,0.3288631382584572,,1.177654727810464,,0.868467363905232,,Neutral,Neutral,,Neutral,0.4062445985577676,,0.7530425059799333,0.44277,,0.2919328930538532,,0.36735144652692664,,Neutral,,Neutral,,0.6314383084816553,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,neutral,,-0.1531,1.0811,-0.3501,-0.33024769470899,1.1724704115149305e-12,Benign,0.355,ambiguous,-2.726,available,https://doi.org/10.1101/2022.10.22.513328 +N268S,NP_000537:p.Asn268Ser,"hg19,17:g.7577135T>C, hg38,17:g.7673817T>C",,,0.327,"COSMIC,ClinVar,saturation_mutlist",2831391,Uncertain significance,1,,,,,1.26378,-0.15295691370964049,1.0947866666666666,2.2287426788814755,1.1792833333333332,1.7462613394407378,Neutral,Uncertain,Neutral,Neutral,Neutral,0.21406097741235175,0.24869732626003216,0.4547243699333656,0.22076,0.7375266666666667,1.3581768635662328,0.47914333333333337,0.7894684317831164,Neutral,Neutral,Neutral,Neutral,0.8514657498037657,0.5611188526753813,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,uncertain,,-0.1183,1.0811,-6.3575,-1.14138344287833,1.8746849181159628e-06,Benign,0.0787,benign,-3.146,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N268T,NP_000537:p.Asn268Thr,,,,,saturation_mutlist,,,,,,,,0.64838,0.07780171632766723,,1.4858336488146777,,1.0671068244073387,,Neutral,Neutral,,Neutral,0.347271191619333,,0.25422233541154254,-0.05256,,0.6764782706690443,,0.31195913533452213,,Neutral,,Neutral,,0.44518288393519634,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,uncertain,,-0.2489,1.0811,-22.2302,-4.88317032886151,0.0145796015062153,Benign,0.1962,benign,-3.526,available,https://doi.org/10.1101/2022.10.22.513328 +N268V,NP_000537:p.Asn268Val,,,,,saturation_mutlist,,,,,,,,-0.98841,-0.3151680052280426,,0.2844131120909486,,-0.35199844395452573,,Neutral,Neutral,,Neutral,0.47293657643050524,,0.23883297179407223,-1.44277,,-0.16669729488573906,,-0.8047336474428696,,Neutral,,Neutral,,0.4243428540530878,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,neutral,,-0.273,1.0811,-22.2302,-5.43571068450721,0.0160592414790959,Benign,0.3892,ambiguous,-3.679,available,https://doi.org/10.1101/2022.10.22.513328 +N268W,NP_000537:p.Asn268Trp,,,,,saturation_mutlist,,,,,,,,0.94236,-0.2525094568729401,,0.6373823514056066,,0.7898711757028033,,Neutral,Neutral,,Neutral,0.4868189605165772,,1.1821506944554763,0.83209,,-0.21861827146454385,,0.3067358642677281,,Neutral,,Neutral,,0.5717115998971705,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,neutral,,-0.2916,1.0811,-22.2302,-5.51296298197219,0.023095716275161,Benign,0.766,pathogenic,-3.95,available,https://doi.org/10.1101/2022.10.22.513328 +N268Y,NP_000537:p.Asn268Tyr,"hg19,17:g.7577136T>A, hg38,17:g.7673818T>A",,,0.561,"cBioPortal,ClinVar,saturation_mutlist",827405,Uncertain significance,1,,,,,0.34273,0.04516724824905396,-0.40362666666666663,1.0434571372820447,-0.030448333333333327,0.6930935686410223,Neutral,Neutral,Neutral,Neutral,Neutral,0.5356770937259736,0.27332688565566,1.0982605598831505,0.18529,1.8291366666666669,-0.06674964486962587,1.0072133333333335,0.05927017756518707,Neutral,Neutral,Neutral,Neutral,1.4566445551868703,0.3957914143535465,9.629,4.22,12.17,5.374,,True,9.629,,neutral,neutral,neutral,,True,12.17,,neutral,neutral,neutral,neutral,,-0.2701,1.0811,-22.2302,-5.04988168903457,0.0013933634097833,Benign,0.2266,benign,-3.712,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269A,NP_000537:p.Ser269Ala,,,,,saturation_mutlist,,,,,,,,-0.50224,0.1400759267807007,,-0.10538630323244254,,-0.3038131516162213,,Neutral,Neutral,,Neutral,0.21302577785298651,,0.23982978534794352,-0.39498,,-0.34124132328990714,,-0.36811066164495354,,Neutral,,Neutral,,0.2071805897728261,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,uncertain,,-0.1798,1.0942,-22.2302,-2.72864476397273,0.2876327388859218,Benign,0.1426,benign,-3.555,available,https://doi.org/10.1101/2022.10.22.513328 +S269C,NP_000537:p.Ser269Cys,"hg19,17:g.7577133T>A, hg38,17:g.7673815T>A",,,0.460,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2575177,Benign,0,,,,,-0.75828,-0.3681187129020691,0.22914,0.5062241864196023,-0.26456999999999997,-0.12602790679019882,Neutral,Neutral,Neutral,Neutral,Neutral,0.2548217323925265,0.3313967442004624,0.2088284403141351,-0.47332,-0.10884333333333335,-0.0646789954261525,-0.2910816666666667,-0.26899949771307624,Neutral,Neutral,Neutral,Neutral,0.17243221592524088,0.22127156109415988,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.1209,1.0942,-0.803,-1.55477986731131,4.765649891038397e-08,Benign,0.0938,benign,-3.03,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269D,NP_000537:p.Ser269Asp,,,,,saturation_mutlist,,,,,,,,0.79619,1.1904731726646423,,1.212529940940659,,1.0043599704703294,,Neutral,Uncertain,,Neutral,0.35763847934270354,,0.21356956639204625,0.68982,,0.4289843639619361,,0.559402181980968,,Neutral,,Neutral,,0.1637267818744838,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.2784,1.0942,-22.2302,-5.91168618561201,0.8637109441364133,Pathogenic,0.9234,pathogenic,-4.334,available,https://doi.org/10.1101/2022.10.22.513328 +S269E,NP_000537:p.Ser269Glu,,,,,saturation_mutlist,,,,,,,,0.12519,0.48971144437789915,,0.9183043939853145,,0.5217471969926573,,Neutral,Neutral,,Neutral,0.3440138114975465,,0.43348765553437746,0.28349,,0.033689189305045796,,0.1585895946525229,,Neutral,,Neutral,,0.10920201378554206,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.2516,1.0942,-22.2302,-5.91168618561201,0.6869341144660784,Pathogenic,0.9531,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328 +S269F,NP_000537:p.Ser269Phe,,,,,saturation_mutlist,,,,,,,,-0.43918,-0.168065664768219,,-0.33537977639481337,,-0.38727988819740666,,Neutral,Neutral,,Neutral,0.35400708595149116,,0.2211923061144236,-0.45584,,-1.3216634582793532,,-0.8887517291396766,,Neutral,,Neutral,,0.5527934336363163,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.2578,1.0942,-22.2302,-5.58557411384376,0.6495342530027585,Uncertain,0.7539,pathogenic,-4.022,available,https://doi.org/10.1101/2022.10.22.513328 +S269G,NP_000537:p.Ser269Gly,"hg19,17:g.7577133T>C, hg38,17:g.7673815T>C",,,0.688,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.61398,0.8704065036773682,1.14558,1.231955173367263,0.87978,0.9229675866836314,Neutral,Neutral,Neutral,Neutral,Neutral,0.2053772968101841,0.33630864227174817,0.2695802941837759,0.15858,0.09002333333333334,1.0954365509726378,0.12430166666666667,0.6270082754863189,Neutral,Neutral,Neutral,Neutral,0.2403697070949018,0.2354210494044085,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,uncertain,,-0.1889,1.0942,-22.2302,-6.11743999468942,0.7232675333413295,Pathogenic,0.2576,benign,-3.992,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269H,NP_000537:p.Ser269His,,,,,saturation_mutlist,,,,,,,,0.35305,0.4072138261795044,,0.050950564335471314,,0.20200028216773563,,Neutral,Neutral,,Neutral,0.35123497210879207,,0.23616666179045315,0.54849,,-0.7327731332208413,,-0.09214156661042061,,Neutral,,Neutral,,0.46725408893670445,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.259,1.0942,-22.2302,-5.58557411384376,0.8567273299230327,Pathogenic,0.7788,pathogenic,-4.179,available,https://doi.org/10.1101/2022.10.22.513328 +S269I,NP_000537:p.Ser269Ile,"hg19,17:g.7577132C>A, hg38,17:g.7673814C>A",,,0.810,"COSMIC,ClinVar,saturation_mutlist",2575169,Likely pathogenic,0,,,,,-1.08257,-0.3027238368988037,-0.82925,-0.26613399110219166,-0.95591,-0.6743519955510958,Neutral,Neutral,Neutral,Neutral,Neutral,0.480065381449631,0.38066008170019616,0.25474028869805104,-0.66296,-0.4309533333333333,-1.5300840872983636,-0.5469566666666666,-1.0965220436491818,Neutral,Neutral,Neutral,Neutral,0.3574957531060878,0.22485553149637175,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.261,1.0942,-22.2302,-3.98265316785276,0.2235202932537445,Benign,0.4663,ambiguous,-3.882,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269K,NP_000537:p.Ser269Lys,,,,,saturation_mutlist,,,,,,,,-0.77921,0.7575938272476196,,0.6176391299485083,,-0.08078543502574581,,Neutral,Neutral,,Neutral,0.46469720931477076,,0.43311153761321686,-0.2536,,0.04104452326549027,,-0.10627773836725486,,Neutral,,Neutral,,0.06437416604053163,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.2684,1.0942,-22.2302,-4.36669348320052,0.1741881079372422,Benign,0.9767,pathogenic,-3.919,available,https://doi.org/10.1101/2022.10.22.513328 +S269L,NP_000537:p.Ser269Leu,,,,,saturation_mutlist,,,,,,,,-0.96957,0.2838246023654938,,-0.4859787010537642,,-0.7277743505268821,,Neutral,Neutral,,Neutral,0.5267810156425716,,0.34977312078619227,-0.37303,,-1.5679316334039115,,-0.9704808167019557,,Neutral,,Neutral,,0.33399851937142594,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.2572,1.0942,-22.2302,-4.39683064233223,0.6487539187709113,Uncertain,0.4537,ambiguous,-3.997,available,https://doi.org/10.1101/2022.10.22.513328 +S269M,NP_000537:p.Ser269Met,,,,,saturation_mutlist,,,,,,,,-1.61381,0.053638153076171875,,-0.07307549425926592,,-0.843442747129633,,Neutral,Neutral,,Neutral,0.4120170525834251,,0.19379453769952937,-1.06617,,-0.9833340077986766,,-1.0247520038993383,,Neutral,,Neutral,,0.24327448730274406,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.2283,1.0942,-22.2302,-4.61654398982983,0.7778011431218738,Pathogenic,0.5609,ambiguous,-4.08,available,https://doi.org/10.1101/2022.10.22.513328 +S269N,NP_000537:p.Ser269Asn,"hg19,17:g.7577132C>T, hg38,17:g.7673814C>T",,,0.729,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3076193,Uncertain significance,1,,,,,0.21463,0.9498328453302384,-0.027666666666666673,0.4470955489079152,0.09348166666666666,0.3308627744539576,Neutral,Neutral,Neutral,Neutral,Neutral,0.3508185192541022,0.4121582435047113,0.13537342286733847,0.50913,-0.009410000000000002,-0.2174710687809637,0.24985999999999997,0.14582946560951815,Neutral,Neutral,Neutral,Neutral,0.19113315062193337,0.13288020925437696,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.1291,1.0942,-7.9424,-4.25800922113961,0.4034656080538056,Uncertain,0.4728,ambiguous,-3.77,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269P,NP_000537:p.Ser269Pro,,,,,saturation_mutlist,,,,,,,,0.06656,1.1845920610427856,,2.4744590694637374,,1.2705095347318687,,Uncertain,Uncertain,,Neutral,0.33251080351348894,,0.4403019254608218,-0.17405,,0.7891419947563204,,0.3075459973781602,,Neutral,,Neutral,,0.10290825971610675,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.2654,1.0942,-8.9424,-4.45084374383499,0.7552530448635252,Pathogenic,0.9168,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +S269Q,NP_000537:p.Ser269Gln,,,,,saturation_mutlist,,,,,,,,-0.06184,0.37728744864463803,,0.4833543515217089,,0.21075717576085445,,Neutral,Neutral,,Neutral,0.35763730482866807,,0.26084944946162014,0.32231,,-0.4088602342877523,,-0.04327511714387616,,Neutral,,Neutral,,0.14735535482716566,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.2217,1.0942,-22.2302,-5.91168618561201,0.850662972355603,Pathogenic,0.887,pathogenic,-4.3,available,https://doi.org/10.1101/2022.10.22.513328 +S269R,NP_000537:p.Ser269Arg,"hg19,17:g.7577131G>C, hg19,17:g.7577133T>G, hg38,17:g.7673813G>C, hg38,17:g.7673813G>T, hg38,17:g.7673815T>G",,,"0.793, 0.812","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2113149, 647256","Uncertain significance, Uncertain significance","2, 1",,,,,-0.51171,0.716982991695404,-0.22789333333333336,0.03660673925448762,-0.3698016666666667,-0.2375516303727562,Neutral,Neutral,Neutral,Neutral,Neutral,0.43528897091460167,0.46956770973121886,0.30461405500984573,0.12178,0.6022666666666666,-0.5707168178353969,0.3620233333333333,-0.22446840891769843,Neutral,Neutral,Neutral,Neutral,0.5918389095203375,0.18127898393371347,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.2736,1.0942,-22.2302,-4.35152183098193,0.17116262508089,Benign,0.9398,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269T,NP_000537:p.Ser269Thr,"hg19,17:g.7577132C>G, hg38,17:g.7673814C>G",,,0.603,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.61423,-0.18473153829574585,-0.18061000000000002,0.16937597392317336,-0.39742000000000005,-0.22242701303841333,Neutral,Neutral,Neutral,Neutral,Neutral,0.1972491193005659,0.3067988856998452,0.17114560453899363,-0.29669,-0.06417,-0.5037073525159519,-0.18043,-0.40019867625797595,Neutral,Neutral,Neutral,Neutral,0.27159043613500083,0.22261456736013244,30.29,5.852,21.965,8.844,P,True,30.29,1.734,neutral,neutral,potentially_damaging,P,True,21.965,2.027,neutral,uncertain,uncertain,neutral,,-0.0924,1.0942,-6.9425,-1.69761692650551,0.0190920773132126,Benign,0.1301,benign,-3.5,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269V,NP_000537:p.Ser269Val,,,,,saturation_mutlist,,,,,,,,-1.14667,-0.41370044231414793,,-0.4849883836824423,,-0.8158291918412212,,Neutral,Neutral,,Neutral,0.38330878410583935,,0.1332951638965528,-0.88058,,-1.4963488985549975,,-1.1884644492774987,,Neutral,,Neutral,,0.1946638282135387,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.2352,1.0942,-22.2302,-3.56821591465137,0.0648208850928016,Benign,0.3851,ambiguous,-3.57,available,https://doi.org/10.1101/2022.10.22.513328 +S269W,NP_000537:p.Ser269Trp,,,,,saturation_mutlist,,,,,,,,0.01809,-0.3573246908187866,,-0.32157003543829427,,-0.15174001771914714,,Neutral,Neutral,,Neutral,0.4510983139272906,,0.39737844678480533,-0.70817,,-1.3668703811473168,,-1.0375201905736584,,Neutral,,Neutral,,0.5397396583720567,30.29,5.852,21.965,8.844,P,True,30.29,1.734,damaging,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.2675,1.0942,-22.2302,-5.58557411384376,0.8438632066767293,Pathogenic,0.8497,pathogenic,-4.384,available,https://doi.org/10.1101/2022.10.22.513328 +S269Y,NP_000537:p.Ser269Tyr,,,,,saturation_mutlist,,,,,,,,-0.36131,-0.14368988037109376,,-0.17349251459840154,,-0.2674012572992008,,Neutral,Neutral,,Neutral,0.4238736413641452,,0.24375377570922632,-0.3781,,-1.120733200560227,,-0.7494166002801135,,Neutral,,Neutral,,0.572705921885187,30.29,5.852,21.965,8.844,P,True,30.29,1.734,uncertain,neutral,potentially_damaging,P,True,21.965,2.027,uncertain,uncertain,uncertain,neutral,,-0.2626,1.0942,-22.2302,-5.06353889053765,0.7717714500532307,Pathogenic,0.6829,pathogenic,-4.041,available,https://doi.org/10.1101/2022.10.22.513328 +F270A,NP_000537:p.Phe270Ala,,,,,saturation_mutlist,,,,,,,,5.10476,2.478992772102356,,4.058005467106953,,4.581382733553476,,Destabilizing,Destabilizing,,Destabilizing,0.32045802704568216,,0.473032879682,1.66528,,3.3591577475888568,,2.5122188737944287,,Uncertain,,Uncertain,,0.4421673464883365,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.4454,0.0423,-22.2302,-6.91503110018152,0.8488288460465558,Pathogenic,0.9956,pathogenic,-4.434,available,https://doi.org/10.1101/2022.10.22.513328 +F270C,NP_000537:p.Phe270Cys,"hg19,17:g.7577129A>C, hg19,17:g.7673811A>C, hg38,17:g.7673811A>C",,,0.929,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376597,Likely pathogenic,2,,,,,4.48348,1.505154972076416,4.162133333333333,3.9294301778322454,4.322806666666667,4.2064550889161225,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.2786506614599666,0.18708795762659053,0.5115686011302654,1.38383,3.8839,3.3743209141080173,2.633865,2.3790754570540087,Uncertain,Uncertain,Uncertain,Uncertain,0.6171082378859212,0.26266706714344634,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.4135,0.0423,-22.2302,-5.54328700988529,0.7272656398596062,Pathogenic,0.9612,pathogenic,-4.002,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F270D,NP_000537:p.Phe270Asp,,,,,saturation_mutlist,,,,,,,,5.65034,3.205576391220093,,5.313123190340792,,5.481731595170396,,Destabilizing,Destabilizing,,Destabilizing,0.2869778122566515,,0.5398094504799728,3.37042,,4.3692941277723785,,3.8698570638861893,,Destabilizing,,Destabilizing,,0.39325789908456793,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.5683,0.0423,-22.2302,-6.96496115851168,0.8695558971552554,Pathogenic,0.9998,pathogenic,-4.829,available,https://doi.org/10.1101/2022.10.22.513328 +F270E,NP_000537:p.Phe270Glu,,,,,saturation_mutlist,,,,,,,,5.24543,2.886450099945068,,4.879846341369933,,5.062638170684966,,Destabilizing,Destabilizing,,Destabilizing,0.2845945493381277,,0.6434714818209484,2.89588,,3.904191111042375,,3.400035555521187,,Uncertain,,Destabilizing,,0.31146349511598814,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.5377,0.0423,-22.2302,-6.96496115851168,0.854007999523428,Pathogenic,0.9995,pathogenic,-4.784,available,https://doi.org/10.1101/2022.10.22.513328 +F270G,NP_000537:p.Phe270Gly,,,,,saturation_mutlist,,,,,,,,6.24758,3.034108486175537,,5.824806634177986,,6.036193317088993,,Destabilizing,Destabilizing,,Destabilizing,0.30734750492249735,,0.5002420904178421,2.50931,,4.962308014603031,,3.7358090073015155,,Uncertain,,Destabilizing,,0.4204964939338278,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.4807,0.0423,-22.2302,-7.69257588144644,0.8359972659831771,Pathogenic,0.9987,pathogenic,-4.615,available,https://doi.org/10.1101/2022.10.22.513328 +F270H,NP_000537:p.Phe270His,,,,,saturation_mutlist,,,,,,,,3.83915,2.749794101715088,,2.733525298878863,,3.2863376494394316,,Uncertain,Destabilizing,,Destabilizing,0.360689004355485,,0.2432869473779583,2.1374,,2.2391643247820903,,2.188282162391045,,Uncertain,,Uncertain,,0.3724978429348847,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.4729,0.0423,-22.2302,-4.63948944499405,0.8691503084231919,Pathogenic,0.9957,pathogenic,-4.57,available,https://doi.org/10.1101/2022.10.22.513328 +F270I,NP_000537:p.Phe270Ile,"hg19,17:g.7577130A>T, hg19,17:g.7673812A>T, hg38,17:g.7673812A>T",,,0.938,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376596,Conflicting classifications of pathogenicity,1,,,,,2.91008,1.2344364070892333,2.9918366666666665,2.1624186707267303,2.9509583333333333,2.5362493353633653,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.283288673325963,0.4125473327456565,0.6208253816992898,1.21154,1.55567,1.8227402593031474,1.3836050000000002,1.5171401296515739,Neutral,Neutral,Neutral,Neutral,0.8720992098379634,0.09591777674087777,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.3893,0.0423,-22.2302,-4.46839511542668,0.4034463313779977,Uncertain,0.9152,pathogenic,-3.721,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F270K,NP_000537:p.Phe270Lys,"hg19,17:g.7577128_7577130delinsTTT",,,,"cBioPortal,saturation_mutlist",,,,,,,,4.78977,2.9124056339263915,,4.930451674223118,,4.860110837111559,,Destabilizing,Destabilizing,,Destabilizing,0.3332602141800702,,0.6754608174439064,2.41789,,3.7635566167611323,,3.090723308380566,,Uncertain,,Destabilizing,,0.7618184720626267,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.5446,0.0423,-22.2302,-7.69257588144644,0.8667230697865627,Pathogenic,0.9994,pathogenic,-4.744,available,https://doi.org/10.1101/2022.10.22.513328 +F270L,NP_000537:p.Phe270Leu,"hg19,17:g.7577128A>C, hg19,17:g.7577128A>T, hg19,17:g.7577130A>G, hg19,17:g.7673810A>C, hg19,17:g.7673812A>G, hg38,17:g.7673810A>C, hg38,17:g.7673810A>T, hg38,17:g.7673812A>G",,,"0.827, 0.935","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","1431729, 634778","Conflicting classifications of pathogenicity, Conflicting classifications of pathogenicity","1, 1",,,,,2.49988,1.5445454216003418,2.6869599999999996,1.8473704570099885,2.59342,2.1736252285049944,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.39661537388573587,0.26936657563006344,0.4311795671354565,0.0864,1.7011299999999998,1.3806566332816346,0.8937649999999999,0.7335283166408173,Neutral,Neutral,Neutral,Neutral,0.8282656321494933,0.19150074795313402,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.2836,0.0423,-8.9424,-3.45216713202377,0.3973499295870359,Uncertain,0.9944,pathogenic,-3.693,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F270M,NP_000537:p.Phe270Met,,,,,saturation_mutlist,,,,,,,,1.5953,1.4654719591140748,,2.364572186739362,,1.979936093369681,,Uncertain,Uncertain,,Neutral,0.2951004229921509,,0.5173368105683303,-0.67535,,1.8143075884175388,,0.5694787942087693,,Neutral,,Neutral,,0.17367236872339312,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.3824,0.0423,-22.2302,-4.58205857622468,0.5023578242858687,Uncertain,0.9642,pathogenic,-3.83,available,https://doi.org/10.1101/2022.10.22.513328 +F270N,NP_000537:p.Phe270Asn,,,,,saturation_mutlist,,,,,,,,5.39738,3.054235773086548,,3.9104916078584964,,4.653935803929248,,Destabilizing,Destabilizing,,Destabilizing,0.2976399721653348,,0.5301384863414961,2.75556,,2.9953333144018455,,2.8754466572009227,,Uncertain,,Uncertain,,0.5384398568336223,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.498,0.0423,-22.2302,-6.96496115851168,0.8629443161140484,Pathogenic,0.9991,pathogenic,-4.674,available,https://doi.org/10.1101/2022.10.22.513328 +F270P,NP_000537:p.Phe270Pro,,,,,saturation_mutlist,,,,,,,,6.76916,3.22347261428833,,7.6815349800434545,,7.225347490021727,,Destabilizing,Destabilizing,,Destabilizing,0.32904634509136244,,0.51304658781372,4.64668,,7.299674270193017,,5.973177135096508,,Destabilizing,,Destabilizing,,0.16634425680265197,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.5009,0.0423,-8.9424,-7.69257588144644,0.8647623117971187,Pathogenic,0.9999,pathogenic,-4.649,available,https://doi.org/10.1101/2022.10.22.513328 +F270Q,NP_000537:p.Phe270Gln,,,,,saturation_mutlist,,,,,,,,4.72204,2.8870925903320312,,3.803360488712235,,4.262700244356117,,Destabilizing,Destabilizing,,Destabilizing,0.3380713076667126,,0.5592439415188807,2.38167,,3.118167125339056,,2.749918562669528,,Uncertain,,Uncertain,,0.31453328136082365,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.5,0.0423,-22.2302,-6.02793001538936,0.864251922979483,Pathogenic,0.9986,pathogenic,-4.47,available,https://doi.org/10.1101/2022.10.22.513328 +F270R,NP_000537:p.Phe270Arg,,,,,saturation_mutlist,,,,,,,,5.36344,2.748928623199463,,4.10034898326025,,4.7318944916301255,,Destabilizing,Destabilizing,,Destabilizing,0.3077720613025346,,0.646790863269502,3.79101,,2.761188349276841,,3.2760991746384205,,Uncertain,,Destabilizing,,0.6196205713458743,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.5459,0.0423,-22.2302,-7.69257588144644,0.864144345054376,Pathogenic,0.9978,pathogenic,-4.666,available,https://doi.org/10.1101/2022.10.22.513328 +F270S,NP_000537:p.Phe270Ser,"hg19,17:g.7577129A>G, hg19,17:g.7673811A>G, hg38,17:g.7673811A>G",,,0.945,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376594,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,5.2995,2.690603160858154,5.185033333333333,4.834462441621894,5.242266666666667,5.066981220810947,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.28626635592944627,0.05029332913573687,0.521970639714657,2.28971,4.269386666666667,4.179953698835084,3.2795483333333335,3.2348318494175423,Uncertain,Uncertain,Destabilizing,Destabilizing,0.40221063555748443,0.3664770681443741,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.4243,0.0423,-22.2302,-6.91503110018152,0.8687453529404657,Pathogenic,0.9952,pathogenic,-4.405,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F270T,NP_000537:p.Phe270Thr,,,,,saturation_mutlist,,,,,,,,4.61756,2.5502042675018313,,3.7996978920538775,,4.208628946026939,,Destabilizing,Destabilizing,,Destabilizing,0.3203587957035627,,0.5534664806977129,1.39755,,3.204725476257044,,2.301137738128522,,Uncertain,,Uncertain,,0.2460052357024697,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.4706,0.0423,-22.2302,-6.91503110018152,0.8524391291747411,Pathogenic,0.9945,pathogenic,-4.354,available,https://doi.org/10.1101/2022.10.22.513328 +F270V,NP_000537:p.Phe270Val,"hg19,17:g.7577130A>C, hg19,17:g.7673812A>C, hg38,17:g.7673812A>C",,,0.926,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376598,Pathogenic,1,,,Tier I - Strong,1,3.34991,1.5028378009796142,2.9342400000000004,2.4472302136448554,3.142075,2.8985701068224277,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.30762472406238356,0.5033572489461801,0.43171698031984646,1.15307,2.07551,1.9725691702601498,1.61429,1.5628195851300748,Uncertain,Neutral,Neutral,Neutral,0.4755809689912608,0.21208860086009182,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.3836,0.0423,-22.2302,-4.18485049707298,0.5207188382346581,Uncertain,0.882,pathogenic,-3.732,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F270W,NP_000537:p.Phe270Trp,,,,,saturation_mutlist,,,,,,,,3.37485,1.1577046537399291,,1.8445102583250943,,2.6096801291625473,,Uncertain,Uncertain,,Uncertain,0.4940361700721003,,0.20245461116816757,4.18248,,1.1026204709851066,,2.6425502354925534,,Uncertain,,Uncertain,,0.29464913707320267,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,damaging,,-0.3689,0.0423,-22.2302,-4.63948944499405,0.8660040601329309,Pathogenic,0.9186,pathogenic,-4.442,available,https://doi.org/10.1101/2022.10.22.513328 +F270Y,NP_000537:p.Phe270Tyr,"hg38,17:g.7673811A>T",,,0.936,"COSMIC,saturation_mutlist",,,,,,,,1.34861,1.2809807348251343,0.21678333333333333,1.6295959503282835,0.7826966666666667,1.4891029751641418,Neutral,Neutral,Uncertain,Neutral,Neutral,0.38167564474747045,0.07497674143063003,0.05046736910311503,1.38665,0.6448999999999999,1.2362433954065717,1.0157749999999999,1.311446697703286,Neutral,Neutral,Neutral,Neutral,0.34561616349162066,0.2739842756826846,6.178,2.231,3.23,2.026,,True,6.178,,neutral,neutral,neutral,,True,3.23,,neutral,neutral,neutral,uncertain,,-0.3372,0.0423,-22.2302,-4.63948944499405,0.8698200708825938,Pathogenic,0.8656,pathogenic,-4.238,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271A,NP_000537:p.Glu271Ala,"hg19,17:g.7673808T>G",,,,"cBioPortal,saturation_mutlist",,,,,,,,0.41232,1.0973694920539856,,1.0731058132583031,,0.7427129066291516,,Neutral,Uncertain,,Neutral,0.2757422007769511,,0.30140362580533453,0.39158,,1.0082622160737833,,0.6999211080368917,,Neutral,,Neutral,,0.3107137607649822,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.3148,0.0634,-22.2302,-6.17285794794044,0.7184220630176705,Pathogenic,0.8063,pathogenic,-4.092,available,https://doi.org/10.1101/2022.10.22.513328 +E271C,NP_000537:p.Glu271Cys,,,,,saturation_mutlist,,,,,,,,0.07218,0.46743614196777344,,1.4682632771405852,,0.7702216385702926,,Neutral,Neutral,,Neutral,0.28138844611015584,,0.26738514586877016,-0.05717,,1.3767527865089004,,0.6597913932544502,,Neutral,,Neutral,,0.3153236103136791,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.3841,0.0634,-22.2302,-6.6845952639708,0.8696747628253019,Pathogenic,0.9833,pathogenic,-4.528,available,https://doi.org/10.1101/2022.10.22.513328 +E271D,NP_000537:p.Glu271Asp,"hg19,17:g.7577125C>A, hg19,17:g.7673807C>G, hg38,17:g.7673807C>A, hg38,17:g.7673807C>G",,,"0.843, 0.844","cBioPortal,COSMIC,ClinVar,saturation_mutlist",859912,Uncertain significance,1,,,,,0.82079,1.137235233783722,0.32029666666666673,1.5846160692468712,0.5705433333333334,1.2027030346234355,Neutral,Neutral,Uncertain,Neutral,Neutral,0.34395784983340166,0.34324693777059234,0.17950363115238097,0.74846,1.0086166666666665,1.394482636640201,0.8785383333333332,1.0714713183201006,Neutral,Neutral,Neutral,Neutral,0.3647373514675396,0.23362948675259188,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.2127,0.0634,-8.9424,-2.75745417207769,0.0068975054763492,Benign,0.7768,pathogenic,-3.578,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271F,NP_000537:p.Glu271Phe,,,,,saturation_mutlist,,,,,,,,0.2522,0.9050094056129455,,0.33602531365394844,,0.2941126568269742,,Neutral,Neutral,,Neutral,0.4436212135158555,,0.32450194108943126,-0.17845,,-0.06072496920655698,,-0.11958748460327849,,Neutral,,Neutral,,0.29767416158905047,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.3618,0.0634,-22.2302,-7.14051568551294,0.8683630282278967,Pathogenic,0.9936,pathogenic,-4.672,available,https://doi.org/10.1101/2022.10.22.513328 +E271G,NP_000537:p.Glu271Gly,"hg19,17:g.7577126T>C, hg38,17:g.7673808T>C",,,0.967,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2858983,Uncertain significance,1,,,,,1.47185,1.9471693992614747,1.7829933333333334,2.4701688144634084,1.6274216666666668,1.9710094072317044,Neutral,Uncertain,Uncertain,Neutral,Neutral,0.42499884222601964,0.2072762704433117,0.11686214027185088,1.32133,2.78594,2.1931185732517395,2.053635,1.7572242866258696,Uncertain,Uncertain,Uncertain,Neutral,0.5985032359700879,0.30193264527295754,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.3405,0.0634,-22.2302,-5.1338776088959,0.6242456099800583,Uncertain,0.8534,pathogenic,-4.093,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271H,NP_000537:p.Glu271His,,,,,saturation_mutlist,,,,,,,,1.64531,1.231483850479126,,0.7763286350299299,,1.2108193175149649,,Neutral,Uncertain,,Neutral,0.37860035920862023,,0.251522012465222,0.95907,,0.5447423707215729,,0.7519061853607865,,Neutral,,Neutral,,0.23303530482194193,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.353,0.0634,-22.2302,-6.76498148786276,0.7414448442698767,Pathogenic,0.9738,pathogenic,-4.246,available,https://doi.org/10.1101/2022.10.22.513328 +E271I,NP_000537:p.Glu271Ile,,,,,saturation_mutlist,,,,,,,,-1.26584,0.295273118019104,,-0.16411589964968387,,-0.714977949824842,,Neutral,Neutral,,Neutral,0.5079722931729648,,0.39613829941688106,-1.67534,,-0.2108494026682861,,-0.9430947013341431,,Neutral,,Neutral,,0.3997114742608091,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.3671,0.0634,-22.2302,-7.08214190607596,0.8667602284663278,Pathogenic,0.9811,pathogenic,-4.656,available,https://doi.org/10.1101/2022.10.22.513328 +E271K,NP_000537:p.Glu271Lys,"hg19,17:g.7577127C>T, hg19,17:g.7673809C>T, hg38,17:g.7673809C>T",,,0.935,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406566,Conflicting classifications of pathogenicity,1,,,,,0.07545,1.6392128705978393,0.89365,1.4523126077076436,0.48455000000000004,0.7638813038538218,Neutral,Neutral,Uncertain,Neutral,Neutral,0.3946866086111588,0.1746162489575354,0.21331082734056564,0.41451,2.11542,1.0801894995256245,1.264965,0.7473497497628122,Uncertain,Neutral,Neutral,Neutral,0.49103668885328716,0.38909929663327897,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.269,0.0634,-8.9424,-5.99359737796003,0.638852324463939,Uncertain,0.9532,pathogenic,-4.157,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271L,NP_000537:p.Glu271Leu,"hg19,17:g.7577126_7577127delinsAA, hg38,17:g.7673808_7673809delinsAA",,,,"ClinVar,saturation_mutlist",568838,Uncertain significance,1,,,,,-1.75112,0.45595852613449095,-0.2384333333333333,-0.20715116063728503,-0.9947766666666666,-0.9791355803186426,Neutral,Neutral,Neutral,Neutral,Neutral,0.3765698237782778,0.8875941967037765,0.34380758219666724,-1.86087,0.20736999999999997,-0.2787778360227635,-0.82675,-1.0698239180113818,Neutral,Neutral,Neutral,Neutral,0.10246335182233045,0.2790583190546146,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.3692,0.0634,-22.2302,-6.79199726822656,0.694915266544585,Pathogenic,0.9679,pathogenic,-4.238,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271M,NP_000537:p.Glu271Met,,,,,saturation_mutlist,,,,,,,,-1.2587,0.6882226538658142,,0.34865349173819987,,-0.45502325413090006,,Neutral,Neutral,,Neutral,0.30813816023005614,,0.3024625414957435,-1.53339,,0.27616619827205424,,-0.6286119008639729,,Neutral,,Neutral,,0.3026484334569854,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.3181,0.0634,-22.2302,-7.08214190607596,0.868121252134773,Pathogenic,0.968,pathogenic,-4.636,available,https://doi.org/10.1101/2022.10.22.513328 +E271N,NP_000537:p.Glu271Asn,,,,,saturation_mutlist,,,,,,,,0.55057,1.5473449563980102,,1.2425311137808404,,0.8965505568904202,,Neutral,Uncertain,,Neutral,0.40809043311598825,,0.2664156416336276,0.66287,,1.1884705141996215,,0.9256702570998108,,Neutral,,Neutral,,0.26641125372171903,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.341,0.0634,-22.2302,-3.74959058021178,0.522641305801466,Uncertain,0.9324,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328 +E271P,NP_000537:p.Glu271Pro,"hg38,17:g.7673808_7673809delinsGG",,,,"COSMIC,saturation_mutlist",,,,,,,,-0.98997,1.6209552717208862,2.172336666666667,2.914184275249081,0.5911833333333334,0.9621071376245405,Uncertain,Uncertain,Uncertain,Neutral,Neutral,0.36976029378673964,0.10812685677275341,0.28832870256948423,0.2422,3.660203333333333,2.5486417205601395,1.9512016666666665,1.3954208602800697,Uncertain,Uncertain,Neutral,Neutral,0.5792826682678806,0.30053859196466487,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.4039,0.0634,-8.9424,-6.13874495590501,0.5515815464806931,Uncertain,0.9819,pathogenic,-4.238,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271Q,NP_000537:p.Glu271Gln,"hg19,17:g.7577127C>G, hg19,17:g.7673809C>G, hg38,17:g.7673809C>G",,,0.924,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3634426,Uncertain significance,2,,,,,0.31948,0.8334662294387818,0.11042999999999997,0.8418931416968242,0.21495499999999998,0.5806865708484121,Neutral,Neutral,Neutral,Neutral,Neutral,0.22019200438472264,0.36255960539843185,0.29452979204471114,0.02331,0.6841266666666668,0.8457250374830428,0.3537183333333334,0.43451751874152145,Neutral,Neutral,Neutral,Neutral,0.4805956082704969,0.29626749459882673,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.2873,0.0634,-22.2302,-4.5582696722585,0.728915006186129,Pathogenic,0.7442,pathogenic,-4.064,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271R,NP_000537:p.Glu271Arg,,,,,saturation_mutlist,,,,,,,,0.475,1.8114123034477234,0.93016,1.0753545077223403,0.70258,0.7751772538611701,Neutral,Neutral,Uncertain,Neutral,Neutral,0.42246283424978315,0.4979036224679096,0.16128003358974904,0.71114,1.94399,0.7550139484592581,1.327565,0.733076974229629,Neutral,Neutral,Neutral,Neutral,0.4501412153980127,0.48038207117829923,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.3973,0.0634,-22.2302,-6.34892669683129,0.8708540421658563,Pathogenic,0.959,pathogenic,-4.384,available,https://doi.org/10.1101/2022.10.22.513328 +E271S,NP_000537:p.Glu271Ser,,,,,saturation_mutlist,,,,,,,,1.00064,1.152125678062439,,1.6180191411105282,,1.309329570555264,,Neutral,Uncertain,,Neutral,0.30326243362985483,,0.1624400253971753,0.88141,,1.3933968283054312,,1.1374034141527156,,Neutral,,Neutral,,0.33406520169545967,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.3282,0.0634,-22.2302,-5.58745827247622,0.6642086452207352,Uncertain,0.8257,pathogenic,-4.129,available,https://doi.org/10.1101/2022.10.22.513328 +E271T,NP_000537:p.Glu271Thr,,,,,saturation_mutlist,,,,,,,,-0.02281,0.8106212139129638,,1.0153616885516479,,0.49627584427582394,,Neutral,Neutral,,Neutral,0.38976602257286713,,0.3139849072350303,-0.37663,,0.8806667622348,,0.2520183811174,,Neutral,,Neutral,,0.33825998367619897,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.3441,0.0634,-22.2302,-6.6845952639708,0.8530171405816365,Pathogenic,0.9497,pathogenic,-4.454,available,https://doi.org/10.1101/2022.10.22.513328 +E271V,NP_000537:p.Glu271Val,"hg19,17:g.7577126T>A, hg19,17:g.7673808T>A, hg38,17:g.7673808T>A",,,0.972,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3147994,Likely pathogenic,2,,,,,-0.98131,0.3450621581077576,-0.015306666666666654,0.0858064277055589,-0.49830833333333335,-0.44775178614722055,Neutral,Neutral,Neutral,Neutral,Neutral,0.4629639285798253,0.22618473885054421,0.39316692253436325,-1.466,0.025283333333333324,0.02968931655221113,-0.7203583333333333,-0.7181553417238944,Neutral,Neutral,Neutral,Neutral,0.45442256152420757,0.4388898973369723,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,uncertain,,-0.328,0.0634,-22.2302,-7.08214190607596,0.859649952722136,Pathogenic,0.9457,pathogenic,-4.434,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271W,NP_000537:p.Glu271Trp,,,,,saturation_mutlist,,,,,,,,1.24998,0.7116523122787476,,0.23560873376231783,,0.742794366881159,,Neutral,Neutral,,Neutral,0.3793740116109414,,0.13012702585291144,0.38282,,-0.21188514877411524,,0.08546742561294238,,Neutral,,Neutral,,0.25189011970373465,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.3718,0.0634,-22.2302,-7.14051568551294,0.8708183379723466,Pathogenic,0.9971,pathogenic,-4.797,available,https://doi.org/10.1101/2022.10.22.513328 +E271Y,NP_000537:p.Glu271Tyr,,,,,saturation_mutlist,,,,,,,,0.72775,0.8770603394508362,,0.6674509888911961,,0.697600494445598,,Neutral,Neutral,,Neutral,0.42596506264164735,,0.19279151094346017,0.07901,,0.18435377740308426,,0.13168188870154213,,Neutral,,Neutral,,0.3338795441742611,15.473,4.107,23.695,8.175,,True,15.473,,neutral,neutral,neutral,,True,23.695,,neutral,neutral,neutral,neutral,,-0.3626,0.0634,-22.2302,-6.87743560539688,0.8575961504579961,Pathogenic,0.9894,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328 +V272A,NP_000537:p.Val272Ala,"hg19,17:g.7577123A>G, hg19,17:g.7673805A>G, hg38,17:g.7673805A>G",,,0.658,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",565884,Uncertain significance,1,,,,,3.39736,1.8277060508728027,2.847053333333333,3.1035170733620916,3.1222066666666666,3.2504385366810458,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.22385863269251627,0.4871595580049267,0.25338215363656613,1.63968,2.8981833333333333,2.2688505966491608,2.2689316666666666,1.9542652983245805,Uncertain,Uncertain,Uncertain,Neutral,0.1597075029198343,0.1669304437799319,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,uncertain,,-0.1077,1.4791,-1.2283,-2.15184917570093,0.0017245284391972,Benign,0.9028,pathogenic,-3.32,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V272C,NP_000537:p.Val272Cys,,,,,saturation_mutlist,,,,,,,,2.46133,1.0947885704040528,,2.7503871091581407,,2.6058585545790702,,Uncertain,Uncertain,,Uncertain,0.21076117804124916,,0.18608049187587164,1.23023,,2.3190906768175434,,1.7746603384087716,,Uncertain,,Neutral,,0.14372140016422044,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,uncertain,,-0.2427,1.4791,-22.2302,-4.0008210332106,0.8688226318888297,Pathogenic,0.9792,pathogenic,-4.193,available,https://doi.org/10.1101/2022.10.22.513328 +V272D,NP_000537:p.Val272Asp,,,,,saturation_mutlist,,,,,,,,4.26442,3.142386417388916,,4.619035205643655,,4.441727602821828,,Destabilizing,Destabilizing,,Destabilizing,0.2859716069207501,,0.08000236748356782,3.30607,,3.8116377940750517,,3.558853897037526,,Destabilizing,,Destabilizing,,0.15543983135918416,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,uncertain,,-0.3814,1.4791,-22.2302,-6.48435979193118,0.8690175053985187,Pathogenic,0.9969,pathogenic,-4.629,available,https://doi.org/10.1101/2022.10.22.513328 +V272E,NP_000537:p.Val272Glu,"hg19,17:g.7577123A>T, hg19,17:g.7673805A>T, hg38,17:g.7673805A>T",,,0.806,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376673,Conflicting classifications of pathogenicity,1,,,,,3.78877,2.9226586389541627,4.801703333333333,4.663190007053111,4.295236666666667,4.225980003526556,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.3669905011125649,1.287135786215097,0.16013033719090725,3.90782,3.8921799999999998,3.6546734347194545,3.9,3.7812467173597275,Destabilizing,Destabilizing,Destabilizing,Destabilizing,1.2221994858450889,0.3218646344083825,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,uncertain,,-0.3387,1.4791,-22.2302,-6.48435979193118,0.8707036106879041,Pathogenic,0.9937,pathogenic,-4.549,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V272F,NP_000537:p.Val272Phe,,,,,saturation_mutlist,,,,,,,,8.44859,1.9492851686477661,,3.368802902566074,,5.908696451283037,,Destabilizing,Uncertain,,Destabilizing,0.452408661170328,,0.6984251203669514,7.24857,,1.275542916178191,,4.262056458089096,,Uncertain,,Destabilizing,,1.319145995059326,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,neutral,,-0.292,1.4791,-22.2302,-6.48435979193118,0.8478046969785913,Pathogenic,0.9706,pathogenic,-4.108,available,https://doi.org/10.1101/2022.10.22.513328 +V272G,NP_000537:p.Val272Gly,"hg19,17:g.7577123A>C, hg19,17:g.7673805A>C, hg38,17:g.7673805A>C",,,0.707,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",233323,Conflicting classifications of pathogenicity,1,,,,,5.20297,2.806018009185791,5.36474,5.48817452982572,5.283855,5.34557226491286,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.251165099623289,0.6570907249383453,0.27327048264341997,2.9844,4.873583333333333,4.270239751354173,3.9289916666666667,3.6273198756770864,Uncertain,Uncertain,Destabilizing,Destabilizing,0.4130641874522115,0.13557509099116846,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,uncertain,,-0.2411,1.4791,-2.7331,-2.44295666055379,0.5781006223116738,Uncertain,0.8186,pathogenic,-3.722,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V272H,NP_000537:p.Val272His,,,,,saturation_mutlist,,,,,,,,8.35465,2.669983367919922,,4.009836197313548,,6.182243098656773,,Destabilizing,Destabilizing,,Destabilizing,0.3636091793579514,,0.4493075257787258,7.63333,,2.3591531571191013,,4.996241578559551,,Uncertain,,Destabilizing,,0.8882538488012353,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,neutral,,-0.3844,1.4791,-22.2302,-6.48435979193118,0.8608250919014535,Pathogenic,0.9991,pathogenic,-4.637,available,https://doi.org/10.1101/2022.10.22.513328 +V272I,NP_000537:p.Val272Ile,,,,,saturation_mutlist,,,,,,,,1.02828,0.33919463157653806,,0.5249692954111441,,0.776624647705572,,Neutral,Neutral,,Neutral,0.18999343735970076,,0.2092178715645179,0.69597,,0.4626127904781783,,0.5792913952390891,,Neutral,,Neutral,,0.2554796699570017,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,neutral,,-0.1504,1.4791,-22.2302,-3.22135203996412,0.1719615117827245,Benign,0.3344,benign,-3.504,available,https://doi.org/10.1101/2022.10.22.513328 +V272K,NP_000537:p.Val272Lys,"hg19,17:g.7577123_7577124delinsTT, hg38,17:g.7673805_7673806delinsTT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,6.92574,2.7036102485656737,7.752043333333333,6.925843286508912,7.338891666666667,6.925791643254456,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.33391384171213345,2.1228796741899645,0.6770641095642366,6.02914,5.458503333333333,4.346902202284212,5.743821666666666,5.188021101142105,Destabilizing,Destabilizing,Destabilizing,Destabilizing,1.7562844128316906,0.9454136813576407,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,neutral,,-0.3777,1.4791,-22.2302,-6.48435979193118,0.8650754758083341,Pathogenic,0.9971,pathogenic,-4.652,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V272L,NP_000537:p.Val272Leu,"hg19,17:g.7577124C>A, hg19,17:g.7577124C>G, hg19,17:g.7673806C>A, hg19,17:g.7673806C>G, hg38,17:g.7673806C>A, hg38,17:g.7673806C>G",,,0.878,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","574679, 12358","Pathogenic, Pathogenic/Likely pathogenic","2, 2",Oncogenic,1,Tier II - Potential,1,1.46302,1.235099058151245,1.6021533333333335,1.324097454400696,1.5325866666666668,1.393558727200348,Neutral,Neutral,Uncertain,Neutral,Neutral,0.3367312300089138,0.6589298629512014,0.2793234123186205,1.62183,1.02642,0.9127160224817273,1.324125,1.2672730112408637,Neutral,Neutral,Neutral,Neutral,0.5446893788818234,0.39637150236719665,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,neutral,,-0.2155,1.4791,-22.2302,-3.54364476514723,0.2306612163995733,Benign,0.9653,pathogenic,-3.728,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V272M,NP_000537:p.Val272Met,"hg19,17:g.7577124C>T, hg19,17:g.7577124_7577125delinsTT, hg19,17:g.7673806C>T, hg38,17:g.7673806C>T",,3.9857787415e-06,0.907,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",185814,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,1.76139,1.6515932750701905,3.062586666666667,2.5100070177411857,2.4119883333333334,2.135698508870593,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.3901284948709277,0.5627366085084171,0.36699870327724493,1.50829,1.1441033333333335,1.6077699203782834,1.3261966666666667,1.5580299601891416,Neutral,Neutral,Neutral,Neutral,0.6976414746048926,0.5881996253518655,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,neutral,,-0.2245,1.4791,-22.2302,-4.14864059378533,0.7501014659611975,Pathogenic,0.9572,pathogenic,-4.149,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V272N,NP_000537:p.Val272Asn,,,,,saturation_mutlist,,,,,,,,3.07796,2.9138754749298097,,3.0317886803375274,,3.0548743401687637,,Destabilizing,Destabilizing,,Destabilizing,0.2952527917846504,,0.19891148706639136,2.86373,,2.4977705364086744,,2.680750268204337,,Uncertain,,Uncertain,,0.1753763337526892,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,uncertain,,-0.3693,1.4791,-22.2302,-6.48435979193118,0.869897475692885,Pathogenic,0.989,pathogenic,-4.536,available,https://doi.org/10.1101/2022.10.22.513328 +V272P,NP_000537:p.Val272Pro,,,,,saturation_mutlist,,,,,,,,7.00607,2.9963769054412843,,6.399011936095754,,6.702540968047877,,Destabilizing,Destabilizing,,Destabilizing,0.26524816265335716,,0.3234865175074486,4.6159,,6.176882789900989,,5.396391394950495,,Destabilizing,,Destabilizing,,0.5551381768642059,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,uncertain,,-0.3514,1.4791,-8.9424,-5.53858570879084,0.8550691795977238,Pathogenic,0.9955,pathogenic,-4.424,available,https://doi.org/10.1101/2022.10.22.513328 +V272Q,NP_000537:p.Val272Gln,,,,,saturation_mutlist,,,,,,,,4.09807,2.6416766023635865,,3.599800630456247,,3.8489353152281236,,Destabilizing,Destabilizing,,Destabilizing,0.3866877067351931,,0.24909113766620397,4.09808,,2.768039437711837,,3.433059718855919,,Uncertain,,Destabilizing,,0.42267317293289436,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,uncertain,,-0.3494,1.4791,-22.2302,-6.48435979193118,0.8513025835516409,Pathogenic,0.9951,pathogenic,-4.6,available,https://doi.org/10.1101/2022.10.22.513328 +V272R,NP_000537:p.Val272Arg,,,,,saturation_mutlist,,,,,,,,9.73873,2.7303534507751466,,5.890706737225237,,7.814718368612619,,Destabilizing,Destabilizing,,Destabilizing,0.32752142781821547,,0.6253319459089932,8.86675,,3.4100279112883296,,6.138388955644165,,Destabilizing,,Destabilizing,,0.9874755984160558,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,neutral,,-0.3987,1.4791,-22.2302,-6.48435979193118,0.8544026511294832,Pathogenic,0.9939,pathogenic,-4.654,available,https://doi.org/10.1101/2022.10.22.513328 +V272S,NP_000537:p.Val272Ser,,,,,saturation_mutlist,,,,,,,,4.10637,2.353217511177063,,3.996873183842979,,4.0516215919214895,,Destabilizing,Destabilizing,,Destabilizing,0.32394228257968904,,0.24312074301675848,2.16485,,3.1778132886436956,,2.6713316443218478,,Uncertain,,Uncertain,,0.07484115821597734,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,uncertain,,-0.3185,1.4791,-22.2302,-3.27956985911653,0.8706145190734547,Pathogenic,0.9577,pathogenic,-4.22,available,https://doi.org/10.1101/2022.10.22.513328 +V272T,NP_000537:p.Val272Thr,,,,,saturation_mutlist,,,,,,,,2.13167,1.6203277397155762,,2.4722985505199158,,2.301984275259958,,Uncertain,Uncertain,,Uncertain,0.280659183512724,,0.22165316265116014,1.04713,,2.036699828583364,,1.5419149142916821,,Uncertain,,Neutral,,0.08652757438468135,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,uncertain,,-0.2339,1.4791,-22.2302,-3.03160401968157,0.5298429161628423,Uncertain,0.9045,pathogenic,-3.678,available,https://doi.org/10.1101/2022.10.22.513328 +V272W,NP_000537:p.Val272Trp,,,,,saturation_mutlist,,,,,,,,13.38237,2.1792440748214723,,5.535058931056483,,9.458714465528242,,Destabilizing,Destabilizing,,Destabilizing,0.5121642250814586,,0.9682471603256243,15.75351,,2.4073635052885245,,9.080436752644262,,Uncertain,,Destabilizing,,1.6688318741567392,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,neutral,,-0.3325,1.4791,-22.2302,-6.48435979193118,0.870378770601084,Pathogenic,0.9995,pathogenic,-4.624,available,https://doi.org/10.1101/2022.10.22.513328 +V272Y,NP_000537:p.Val272Tyr,,,,,saturation_mutlist,,,,,,,,11.85362,2.2053998422622683,,4.706550404062284,,8.280085202031142,,Destabilizing,Destabilizing,,Destabilizing,0.47687103343662385,,0.755792983008603,10.35628,,2.038817198207114,,6.197548599103557,,Uncertain,,Destabilizing,,1.5161417942728912,0.072,0.296,0.57,1.37,,False,0.072,,neutral,neutral,neutral,,False,0.57,,neutral,neutral,neutral,neutral,,-0.3354,1.4791,-22.2302,-6.48435979193118,0.87068422867261,Pathogenic,0.9967,pathogenic,-4.614,available,https://doi.org/10.1101/2022.10.22.513328 +R273A,NP_000537:p.Arg273Ala,,,,,saturation_mutlist,,,,,,,,1.02185,0.657378226518631,,0.9057696340627658,,0.9638098170313829,,Neutral,Neutral,,Neutral,0.3013708446106885,,0.18877285868909283,0.89893,,1.2075575110696526,,1.0532437555348264,,Neutral,,Neutral,,0.14732087140541514,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.4036,0.0682,-22.2302,-7.11021169620391,0.8492271311929989,Pathogenic,0.9989,pathogenic,-4.611,available,https://doi.org/10.1101/2022.10.22.513328 +R273C,NP_000537:p.Arg273Cys,"hg19,17:g.7577121G>A, hg19,17:g.7577121_7577122delinsAA, hg19,17:g.7673803G>A, hg38,17:g.7673803G>A, hg38,17:g.7673803_7673804delinsAG",0.0,1.195933825e-05,0.901,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",43594,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,0.666,-0.22050299644470214,0.9099766666666667,1.415540076024632,0.7879883333333333,1.040770038012316,Neutral,Neutral,Neutral,Neutral,Neutral,0.19956688858458518,0.27701673431200663,0.1973030975948942,0.52491,0.7841266666666665,1.5136287723258037,0.6545183333333333,1.0192693861629019,Neutral,Neutral,Neutral,Neutral,0.744400185040875,0.17503702732850007,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,stabilizing,-0.4124,0.0682,-22.2302,-4.01724918554044,0.5826370316456644,Uncertain,0.9945,pathogenic,-4.172,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273D,NP_000537:p.Arg273Asp,,,,,saturation_mutlist,,,,,,,,1.52611,1.0373956751823425,,1.9508702171407002,,1.7384901085703501,,Neutral,Uncertain,,Neutral,0.523812989866981,,0.5339024325688204,1.46678,,1.9125462244905425,,1.6896631122452712,,Neutral,,Neutral,,0.6508919140760172,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.4946,0.0682,-22.2302,-7.62147705658493,0.8480958097282811,Pathogenic,0.9994,pathogenic,-4.82,available,https://doi.org/10.1101/2022.10.22.513328 +R273E,NP_000537:p.Arg273Glu,,,,,saturation_mutlist,,,,,,,,1.28351,0.746147733926773,,1.4757622134086053,,1.3796361067043026,,Neutral,Neutral,,Neutral,0.4994417117871677,,0.6029097853543474,1.19292,,1.3654602493728714,,1.2791901246864357,,Neutral,,Neutral,,0.5304958793999797,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.4398,0.0682,-22.2302,-7.62147705658493,0.8465504936627113,Pathogenic,0.9978,pathogenic,-4.742,available,https://doi.org/10.1101/2022.10.22.513328 +R273F,NP_000537:p.Arg273Phe,,,,,saturation_mutlist,,,,,,,,-0.62149,-0.1838800048828125,,-0.3027603609415846,,-0.4621251804707923,,Neutral,Neutral,,Neutral,0.2418792480312796,,0.23398743468158253,0.18946,,0.08014887243418951,,0.13480443621709476,,Neutral,,Neutral,,0.32785968384618686,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,neutral,,-0.4357,0.0682,-22.2302,-6.57658797529699,0.7772526639907797,Pathogenic,0.9994,pathogenic,-4.706,available,https://doi.org/10.1101/2022.10.22.513328 +R273G,NP_000537:p.Arg273Gly,"hg19,17:g.7577121G>C, hg19,17:g.7577121_7577122delinsCT, hg19,17:g.7673803G>C, hg38,17:g.7673803G>C",,,0.902,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634682,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,2.34561,1.7089809274673462,2.00238,2.4525135842848576,2.173995,2.3990617921424287,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.25779159544239094,0.21254810232039234,0.17813141007185967,1.85268,2.25703,2.5086115800536426,2.054855,2.1806457900268215,Uncertain,Uncertain,Uncertain,Uncertain,0.44142790827042194,0.44252616565377834,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.4389,0.0682,-22.2302,-7.62147705658493,0.7976161942894914,Pathogenic,0.9981,pathogenic,-4.506,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273H,NP_000537:p.Arg273His,"hg19,17:g.7577120C>T, hg19,17:g.7673802C>T, hg38,17:g.7673802C>T",,1.59328272005e-05,0.868,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12366,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,0.99881,-0.02957308292388916,0.26882,0.5262100356455623,0.633815,0.7625100178227812,Neutral,Neutral,Neutral,Neutral,Neutral,0.25409548198481746,0.08943145904359755,0.265573702931657,1.20927,-0.32743666666666665,0.741320159789407,0.44091666666666673,0.9752950798947035,Neutral,Neutral,Neutral,Neutral,0.8645977119382684,0.36189832904726643,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,neutral,-0.2953,0.0682,-6.9425,-2.02805387219135,0.0005848995091557,Benign,0.9889,pathogenic,-3.658,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273I,NP_000537:p.Arg273Ile,"hg38,17:g.7673802_7673803delinsAT",,,,"COSMIC,saturation_mutlist",,,,,,,,-0.63665,-0.3950628590583801,,-0.13528375153571393,,-0.385966875767857,,Neutral,Neutral,,Neutral,0.30229885674220863,,0.23056738673006918,-0.56591,,0.10700701206562764,,-0.2294514939671862,,Neutral,,Neutral,,0.1759426313627187,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.433,0.0682,-22.2302,-7.62147705658493,0.8245679301443909,Pathogenic,0.9983,pathogenic,-4.62,available,https://doi.org/10.1101/2022.10.22.513328 +R273K,NP_000537:p.Arg273Lys,,,,,saturation_mutlist,,,,,,,,-0.04855,0.31619635462760926,,1.139448608741745,,0.5454493043708725,,Neutral,Neutral,,Neutral,0.10889064645761512,,0.35132803559419745,-0.2129,,1.057382389837489,,0.4222411949187445,,Neutral,,Neutral,,0.19256421419410544,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.2938,0.0682,-22.2302,-3.71893592246007,0.0028011958615303,Benign,0.9578,pathogenic,-3.524,available,https://doi.org/10.1101/2022.10.22.513328 +R273L,NP_000537:p.Arg273Leu,"hg19,17:g.7577120C>A, hg19,17:g.7673802C>A, hg38,17:g.7673802C>A",,3.9832068001e-06,0.921,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376655,Pathogenic,2,Oncogenic,1,Tier I - Strong,1,-0.86206,-0.11206814527511597,-0.4026066666666667,-0.4622173403355328,-0.6323333333333334,-0.6621386701677664,Neutral,Neutral,Neutral,Neutral,Neutral,0.26485986628195196,0.7385361468171721,0.2648708806750402,-0.70955,-0.6978433333333335,-0.10266903105505265,-0.7036966666666667,-0.40610951552752633,Neutral,Neutral,Neutral,Neutral,0.5468337959156837,0.21150203369052356,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.406,0.0682,-22.2302,-7.62147705658493,0.847018623778218,Pathogenic,0.9954,pathogenic,-4.49,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273M,NP_000537:p.Arg273Met,,,,,saturation_mutlist,,,,,,,,-0.61621,0.08290256261825561,,0.11514594322762783,,-0.2505320283861861,,Neutral,Neutral,,Neutral,0.23147599558466025,,0.2580383985594076,-0.5571,,0.48140928009130607,,-0.037845359954346985,,Neutral,,Neutral,,0.25400729517187814,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.3719,0.0682,-22.2302,-7.62147705658493,0.8395117372104879,Pathogenic,0.9995,pathogenic,-4.581,available,https://doi.org/10.1101/2022.10.22.513328 +R273N,NP_000537:p.Arg273Asn,,,,,saturation_mutlist,,,,,,,,0.82828,0.47250950932502744,0.8649666666666667,1.1571225202366067,0.8466233333333333,0.9927012601183034,Neutral,Neutral,Neutral,Neutral,Neutral,0.29922902642055654,0.37139793307029717,0.1671698567914524,0.5799,0.35374,1.1860422854205228,0.46682,0.8829711427102613,Neutral,Neutral,Neutral,Neutral,0.4714534284529067,0.33732784300093016,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.4184,0.0682,-22.2302,-7.62147705658493,0.852486193748081,Pathogenic,0.9995,pathogenic,-4.508,available,https://doi.org/10.1101/2022.10.22.513328 +R273P,NP_000537:p.Arg273Pro,"hg19,17:g.7577120C>G, hg19,17:g.7673802C>G, hg38,17:g.7673802C>G",3.1867431485e-05,,0.932,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",231060,Pathogenic/Likely pathogenic,2,,,,,2.68547,2.071652121543884,3.0250566666666665,4.717104604946311,2.8552633333333333,3.7012873024731556,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,0.2252540814821159,0.6908472472905199,0.5576987566114718,2.31807,2.9097500000000003,4.743584512909199,2.61391,3.5308272564545993,Uncertain,Uncertain,Uncertain,Destabilizing,0.3063308371679221,1.6010592436487292,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.5456,0.0682,-22.2302,-7.62147705658493,0.8579175131324634,Pathogenic,0.9988,pathogenic,-4.644,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273Q,NP_000537:p.Arg273Gln,"hg38,17:g.7673801_7673802delinsCT",,,,"COSMIC,saturation_mutlist",,,,,,,,0.22915,0.43802075982093813,0.21179,0.9357920329057855,0.22047,0.5824710164528928,Neutral,Neutral,Neutral,Neutral,Neutral,0.279220023737889,0.05569770611673937,0.31094215253873486,0.22951,0.18288333333333331,1.0782986358822326,0.20619666666666664,0.6539043179411164,Neutral,Neutral,Neutral,Neutral,0.5048060315496329,0.33399348528197786,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.3783,0.0682,-22.2302,-7.62147705658493,0.8220576603716665,Pathogenic,0.9917,pathogenic,-4.02,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273S,NP_000537:p.Arg273Ser,"hg19,17:g.7577121G>T, hg19,17:g.7577121_7577122delinsTT, hg19,17:g.7673803G>T, hg38,17:g.7673801_7673803delinsCGA, hg38,17:g.7673803G>T, hg38,17:g.7673803_7673804delinsTT",,0.0,0.906,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","4530236, 376656",Pathogenic,2,,,Tier I - Strong,1,1.5524,0.5026306319236755,1.26542,1.6296975455195835,1.40891,1.5910487727597917,Neutral,Neutral,Neutral,Neutral,Neutral,0.2539670818956592,0.16168850484805652,0.2427111805092,0.86155,1.11655,1.5886428917297881,0.98905,1.225096445864894,Neutral,Neutral,Neutral,Neutral,0.6848253756980679,0.30181882294578166,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.4041,0.0682,-22.2302,-7.11021169620391,0.7944171265922608,Pathogenic,0.9993,pathogenic,-4.424,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273T,NP_000537:p.Arg273Thr,,,,,saturation_mutlist,,,,,,,,0.81476,0.41153077363967894,,1.124256515389352,,0.9695082576946761,,Neutral,Neutral,,Neutral,0.24518622546055252,,0.21450063975005448,0.72522,,0.9555122654449884,,0.8403661327224942,,Neutral,,Neutral,,0.2351564580791008,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.4084,0.0682,-22.2302,-7.11021169620391,0.8405807145933339,Pathogenic,0.9991,pathogenic,-4.472,available,https://doi.org/10.1101/2022.10.22.513328 +R273V,NP_000537:p.Arg273Val,"hg19,17:g.7577120_7577121delinsAC",,,,"cBioPortal,saturation_mutlist",,,,,,,,-0.41397,-0.3644333076477051,-0.4520433333333333,0.07197718716770513,-0.43300666666666665,-0.17099640641614744,Neutral,Neutral,Neutral,Neutral,Neutral,0.2600949280277099,0.3837795236272456,0.1789568432390337,-0.01233,-0.76916,0.12938220251082258,-0.39074499999999995,0.058526101255411286,Neutral,Neutral,Neutral,Neutral,0.7721075586989159,0.1484882979123298,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,uncertain,,-0.4201,0.0682,-22.2302,-7.62147705658493,0.8327354327096622,Pathogenic,0.9978,pathogenic,-4.608,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273W,NP_000537:p.Arg273Trp,,,,,saturation_mutlist,,,,,,,,0.19383,-0.454862973690033,,-0.31610889274314297,,-0.06113944637157148,,Neutral,Neutral,,Neutral,0.30561616036713724,,0.4456705178534843,0.74087,,-0.1848536154162935,,0.27800819229185325,,Neutral,,Neutral,,0.4146757601763205,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,neutral,,-0.4213,0.0682,-22.2302,-6.57658797529699,0.8502494239592289,Pathogenic,0.9908,pathogenic,-4.482,available,https://doi.org/10.1101/2022.10.22.513328 +R273Y,NP_000537:p.Arg273Tyr,"hg19,17:g.7577120_7577121delinsTA, hg38,17:g.7673802_7673803delinsTA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.57745,-0.41741576194763186,-0.4376433333333334,-0.06166385845665664,-0.5075466666666667,-0.31955692922832835,Neutral,Neutral,Neutral,Neutral,Neutral,0.2081530305159939,0.37267097859759474,0.25912786912133023,0.57482,-1.6978466666666667,0.2389304150204626,-0.5615133333333333,0.4068752075102313,Neutral,Neutral,Neutral,Neutral,1.041189332264897,0.3476311505529195,21.174,5.639,35.415,9.108,,False,21.174,,neutral,neutral,neutral,,False,35.415,,neutral,neutral,neutral,neutral,,-0.425,0.0682,-22.2302,-6.57658797529699,0.8488924651125445,Pathogenic,0.9985,pathogenic,-4.625,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274A,NP_000537:p.Val274Ala,"hg19,17:g.7577117A>G, hg19,17:g.7673799A>G, hg38,17:g.7673799A>G",,,0.847,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376677,Conflicting classifications of pathogenicity,1,,,,,2.49728,1.5732391119003295,3.0668933333333332,2.8700566270387924,2.7820866666666664,2.683668313519396,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.5565371951218885,0.4228210188194947,0.2973667844030038,-1.60205,2.5675766666666666,1.6739371067470354,0.4827633333333333,0.035943553373517734,Uncertain,Neutral,Neutral,Neutral,0.37405665759198686,0.8919428839505568,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.2627,0.9589,-22.2302,-6.80217081269693,0.513378503089405,Uncertain,0.9908,pathogenic,-3.946,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274C,NP_000537:p.Val274Cys,"hg19,17:g.7577117_7577118delinsCA, hg19,17:g.7673799_7673800delinsCA",,,,"cBioPortal,saturation_mutlist",,,,,,,,1.86806,0.9588061332702636,2.38186,2.4575340330786726,2.12496,2.1627970165393364,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.39521020357970105,0.17012252780471682,0.16437071309430887,-0.88278,2.0500000000000003,1.815918835029484,0.5836100000000002,0.46656941751474196,Uncertain,Neutral,Neutral,Neutral,0.20246142496781946,0.6270042348820993,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.2906,0.9589,-22.2302,-6.80217081269693,0.6183762516416454,Uncertain,0.9942,pathogenic,-4.005,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274D,NP_000537:p.Val274Asp,"hg19,17:g.7577117A>T, hg19,17:g.7673799A>T, hg38,17:g.7673799A>T",,,0.889,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376675,Conflicting classifications of pathogenicity,1,,,,,3.25391,2.6543357276916506,4.63662,4.293287500426872,3.945265,3.773598750213436,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.40787789819901266,1.338104473524645,0.41135170285025296,1.88083,4.59841,2.905487587053299,3.2396200000000004,2.3931587935266494,Uncertain,Uncertain,Destabilizing,Uncertain,0.6240747027399844,0.7879955231573104,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.4293,0.9589,-22.2302,-6.80217081269693,0.8390067209925576,Pathogenic,0.9991,pathogenic,-4.632,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274E,NP_000537:p.Val274Glu,"hg19,17:g.7577116_7577117inv, hg38,17:g.7673798_7673799inv",,,,"ClinVar,saturation_mutlist",1417760,Uncertain significance,1,,,,,3.03578,2.8078777027130126,4.94229,4.35485227523283,3.989035,3.6953161376164148,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.3901187414614664,1.4282079450136103,0.636977662921834,1.87673,5.29796,2.5280854193831357,3.587345,2.2024077096915677,Uncertain,Uncertain,Destabilizing,Uncertain,0.6752677539070457,0.9166855400030489,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,uncertain,,-0.3866,0.9589,-22.2302,-6.80217081269693,0.8377260209128816,Pathogenic,0.9984,pathogenic,-4.591,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274F,NP_000537:p.Val274Phe,"hg19,17:g.7577118C>A, hg19,17:g.7577118_7577119delinsAC, hg19,17:g.7673800C>A, hg38,17:g.7673800C>A",,,0.773,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376674,Conflicting classifications of pathogenicity,1,Oncogenic,1,Tier I - Strong,1,9.40429,1.6051615285873413,5.620066666666666,2.804230064401178,7.512178333333333,6.104260032200589,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.576024189913268,2.395099951168821,1.2732787439931639,12.40123,3.8960333333333335,0.3450288027872543,8.148631666666667,6.373129401393627,Destabilizing,Uncertain,Destabilizing,Destabilizing,2.376630265681971,0.687072086349327,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.272,0.9589,-8.9424,-6.80217081269693,0.7351823760284366,Pathogenic,0.9915,pathogenic,-4.236,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274G,NP_000537:p.Val274Gly,"hg19,17:g.7577117A>C, hg19,17:g.7673799A>C, hg38,17:g.7673799A>C",,,0.865,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376676,Conflicting classifications of pathogenicity,1,,,,,4.15702,2.318664855957031,4.916666666666666,5.01530055950601,4.536843333333334,4.586160279753005,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,0.5528850767080148,0.7214150229622027,0.3744782681039162,-1.26932,4.667803333333333,3.608420458178212,1.6992416666666663,1.169550229089106,Uncertain,Uncertain,Neutral,Neutral,0.25795580207125063,1.0017687590108897,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.3885,0.9589,-22.2302,-6.80217081269693,0.7969953163802151,Pathogenic,0.989,pathogenic,-4.405,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274H,NP_000537:p.Val274His,,,,,saturation_mutlist,,,,,,,,10.21718,2.4576755285263063,,3.496520619334154,,6.856850309667077,,Destabilizing,Destabilizing,,Destabilizing,0.6299169772062442,,0.9746750951427098,10.65185,,1.350696007497142,,6.001273003748571,,Uncertain,,Destabilizing,,0.5949993661802765,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.4323,0.9589,-22.2302,-6.80217081269693,0.7879744646698204,Pathogenic,0.9997,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +V274I,NP_000537:p.Val274Ile,"hg19,17:g.7577118C>T, hg38,17:g.7673800C>T",,,0.367,"COSMIC,ClinVar,saturation_mutlist",3460325,Benign,1,,,,,-0.35905,0.17554226398468017,0.6503366666666667,0.35384693814383444,0.14564333333333335,-0.002601530928082768,Neutral,Neutral,Neutral,Neutral,Neutral,0.1835231661207712,0.8411835298091744,0.3513852713215291,1.13975,0.8397933333333333,-0.17913418079699298,0.9897716666666667,0.48030790960150355,Neutral,Neutral,Neutral,Neutral,0.40142778655970274,0.15434392172750333,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.0881,0.9589,-0.6387,-0.311767547129325,1.1555261292893519e-10,Benign,0.0913,benign,-2.786,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274K,NP_000537:p.Val274Lys,,,,,saturation_mutlist,,,,,,,,6.59234,2.5230068874359133,,5.93486247147072,,6.26360123573536,,Destabilizing,Destabilizing,,Destabilizing,0.5339679141980989,,0.993652043824399,5.63258,,3.210780227662889,,4.421680113831444,,Destabilizing,,Destabilizing,,1.104810820944319,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.4256,0.9589,-22.2302,-6.80217081269693,0.7959396260329111,Pathogenic,0.9991,pathogenic,-4.616,available,https://doi.org/10.1101/2022.10.22.513328 +V274L,NP_000537:p.Val274Leu,"hg19,17:g.7577118C>G, hg19,17:g.7673800C>G, hg38,17:g.7673800C>G",,,0.630,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376678,Conflicting classifications of pathogenicity,1,Uncertain significance,1,,,1.11438,1.0079167151451112,2.751246666666667,1.036221140663751,1.9328133333333333,1.0753005703318754,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.316220373732486,0.5785973246471926,0.6396578550104939,1.01462,1.7246033333333333,-0.2031677970474408,1.3696116666666667,0.40572610147627963,Neutral,Neutral,Neutral,Neutral,0.2825673111942632,0.1674335747865157,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.2633,0.9589,-22.2302,-3.55708445755812,0.0156181227142313,Benign,0.967,pathogenic,-3.75,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274M,NP_000537:p.Val274Met,,,,,saturation_mutlist,,,,,,,,1.17107,1.4444645500183106,,2.099783753411827,,1.6354268767059135,,Uncertain,Uncertain,,Neutral,0.4059308097368039,,0.7308327825279988,0.68401,,0.3843794066063273,,0.5341947033031637,,Neutral,,Neutral,,0.2852265784515253,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.2724,0.9589,-22.2302,-4.08312790585859,0.5215561213147862,Uncertain,0.984,pathogenic,-3.964,available,https://doi.org/10.1101/2022.10.22.513328 +V274N,NP_000537:p.Val274Asn,,,,,saturation_mutlist,,,,,,,,2.23189,2.517028126716614,,2.741924828563248,,2.4869074142816237,,Uncertain,Destabilizing,,Uncertain,0.5129907817117999,,0.2445324787779782,1.28473,,1.698011275593154,,1.491370637796577,,Neutral,,Neutral,,0.48771037760427444,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.4171,0.9589,-22.2302,-6.80217081269693,0.6871747564077793,Pathogenic,0.9964,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328 +V274P,NP_000537:p.Val274Pro,,,,,saturation_mutlist,,,,,,,,0.61616,1.7778238010406495,,5.900081406679971,,3.2581207033399853,,Uncertain,Uncertain,,Destabilizing,0.628236266015235,,0.5789638228509871,-3.23475,,4.405151486319024,,0.5852007431595121,,Uncertain,,Neutral,,1.2023914704279304,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.467,0.9589,-22.2302,-5.66142453448823,0.6091732029934918,Uncertain,0.9903,pathogenic,-4.32,available,https://doi.org/10.1101/2022.10.22.513328 +V274Q,NP_000537:p.Val274Gln,,,,,saturation_mutlist,,,,,,,,2.98092,2.565289144515991,,3.3295071383029367,,3.155213569151468,,Uncertain,Destabilizing,,Destabilizing,0.48872006866144524,,0.5404230457342444,2.73931,,1.6293752869452691,,2.1843426434726347,,Uncertain,,Uncertain,,0.6474427929151656,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,uncertain,,-0.3972,0.9589,-22.2302,-6.80217081269693,0.769179437028199,Pathogenic,0.9988,pathogenic,-4.551,available,https://doi.org/10.1101/2022.10.22.513328 +V274R,NP_000537:p.Val274Arg,,,,,saturation_mutlist,,,,,,,,10.81329,2.560623688697815,,4.867233437406011,,7.8402617187030055,,Destabilizing,Destabilizing,,Destabilizing,0.5227161709246223,,1.159061329713003,8.94791,,2.0387153033802803,,5.4933126516901405,,Uncertain,,Destabilizing,,0.8762468522978522,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.4466,0.9589,-22.2302,-6.80217081269693,0.7921654287148987,Pathogenic,0.9974,pathogenic,-4.582,available,https://doi.org/10.1101/2022.10.22.513328 +V274S,NP_000537:p.Val274Ser,,,,,saturation_mutlist,,,,,,,,3.09339,2.1431336402893066,,3.607365369413184,,3.350377684706592,,Destabilizing,Destabilizing,,Destabilizing,0.5366247980740824,,0.3416411216643696,-0.86895,,2.5350825692945693,,0.8330662846472847,,Uncertain,,Neutral,,0.9591872518570905,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.3664,0.9589,-22.2302,-6.80217081269693,0.6436579967094653,Uncertain,0.989,pathogenic,-4.114,available,https://doi.org/10.1101/2022.10.22.513328 +V274T,NP_000537:p.Val274Thr,,,,,saturation_mutlist,,,,,,,,2.26284,1.586401662826538,,2.235709939564903,,2.2492749697824514,,Uncertain,Uncertain,,Uncertain,0.38773576240862817,,0.24084973655365768,0.73929,,1.5233551735292157,,1.131322586764608,,Neutral,,Neutral,,0.631720600098654,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.2817,0.9589,-22.2302,-6.80217081269693,0.7814696396743525,Pathogenic,0.9849,pathogenic,-4.106,available,https://doi.org/10.1101/2022.10.22.513328 +V274W,NP_000537:p.Val274Trp,,,,,saturation_mutlist,,,,,,,,15.31868,1.7050883102416992,,4.550533664066951,,9.934606832033475,,Destabilizing,Uncertain,,Destabilizing,0.7320308360260775,,1.5493255242259627,19.64105,,0.8429998889415339,,10.242024944470767,,Uncertain,,Destabilizing,,0.944949330856051,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.3804,0.9589,-22.2302,-6.80217081269693,0.802960280744946,Pathogenic,0.9997,pathogenic,-4.622,available,https://doi.org/10.1101/2022.10.22.513328 +V274Y,NP_000537:p.Val274Tyr,,,,,saturation_mutlist,,,,,,,,11.75587,1.8833143734931945,,4.02827845805925,,7.892074229029625,,Destabilizing,Uncertain,,Destabilizing,0.7000473579511156,,1.3033767873169633,15.55714,,0.9933275259588973,,8.275233762979449,,Uncertain,,Destabilizing,,1.0061511256515863,0.631,1.496,1.01,1.475,,False,0.631,,neutral,neutral,neutral,,False,1.01,,neutral,neutral,neutral,neutral,,-0.3833,0.9589,-22.2302,-6.80217081269693,0.8242594736669258,Pathogenic,0.9989,pathogenic,-4.56,available,https://doi.org/10.1101/2022.10.22.513328 +C275A,NP_000537:p.Cys275Ala,,,,,saturation_mutlist,,,,,,,,0.45511,0.357772479057312,,0.46633040164973716,,0.4607202008248686,,Neutral,Neutral,,Neutral,0.18683634894893653,,0.19990014311040263,0.2556,,-0.0641207964551055,,0.09573960177244725,,Neutral,,Neutral,,0.301450170771559,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.4905,0.0212,-22.2302,-4.78341883513615,0.8623716638737828,Pathogenic,0.9934,pathogenic,-4.806,available,https://doi.org/10.1101/2022.10.22.513328 +C275D,NP_000537:p.Cys275Asp,,,,,saturation_mutlist,,,,,,,,2.87707,2.0176850509643556,,2.3200659833908888,,2.598567991695444,,Uncertain,Destabilizing,,Uncertain,0.24639786086439378,,0.27278874267907854,1.55703,,0.2508085495548407,,0.9039192747774203,,Neutral,,Neutral,,0.4296610831806881,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,uncertain,,-0.5978,0.0212,-22.2302,-7.96890002094704,0.8637624987638247,Pathogenic,0.9997,pathogenic,-4.96,available,https://doi.org/10.1101/2022.10.22.513328 +C275E,NP_000537:p.Cys275Glu,,,,,saturation_mutlist,,,,,,,,3.29595,1.685595908164978,,2.4826915296400878,,2.889320764820044,,Uncertain,Uncertain,,Uncertain,0.18012393727600548,,0.4179554625005943,1.13147,,0.0582466069437759,,0.594858303471888,,Neutral,,Neutral,,0.4801534001684617,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.5854,0.0212,-22.2302,-7.96890002094704,0.8361657451072021,Pathogenic,1.0,pathogenic,-4.998,available,https://doi.org/10.1101/2022.10.22.513328 +C275F,NP_000537:p.Cys275Phe,"hg19,17:g.7577114C>A, hg19,17:g.7673796C>A, hg38,17:g.7673795_7673796delinsGA, hg38,17:g.7673796C>A",,,0.981,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376582,Pathogenic,2,Oncogenic,1,Tier I - Strong,1,7.59948,0.8696216225624085,2.561223333333333,1.557977308829149,5.080351666666666,4.578728654414574,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,0.14167684172892317,0.600290759123351,0.814298828206276,0.39016,0.7026066666666667,-0.5570974212351557,0.5463833333333333,-0.08346871061757785,Neutral,Neutral,Neutral,Neutral,1.2689056177754998,0.14711944233908011,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.4845,0.0212,-22.2302,-7.96890002094704,0.843023185700425,Pathogenic,0.9978,pathogenic,-4.751,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C275G,NP_000537:p.Cys275Gly,"hg19,17:g.7577115A>C, hg19,17:g.7673797A>C, hg38,17:g.7673797A>C",,,0.957,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1414106,Conflicting classifications of pathogenicity,1,Uncertain significance,1,,,1.45957,0.8682110714912414,1.0124733333333333,2.4818824578463237,1.2360216666666668,1.9707262289231617,Neutral,Uncertain,Neutral,Neutral,Neutral,0.27927274384716144,0.37625486170354727,0.23504562354816508,0.57529,1.2549866666666667,0.9118362812368087,0.9151383333333334,0.7435631406184043,Neutral,Neutral,Neutral,Neutral,0.36049702600098593,0.6421078574178699,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.483,0.0212,-22.2302,-7.96890002094704,0.8605076824267808,Pathogenic,0.9926,pathogenic,-4.641,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C275H,NP_000537:p.Cys275His,,,,,saturation_mutlist,,,,,,,,6.90866,1.4683874368667602,,1.9406427961350217,,4.424651398067511,,Uncertain,Uncertain,,Destabilizing,0.25604634783361696,,0.5005644531361703,1.55305,,-0.3605091650714185,,0.5962704174642908,,Neutral,,Neutral,,0.2963633655077157,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.5962,0.0212,-22.2302,-7.96890002094704,0.8500059631023835,Pathogenic,0.9996,pathogenic,-4.787,available,https://doi.org/10.1101/2022.10.22.513328 +C275I,NP_000537:p.Cys275Ile,,,,,saturation_mutlist,,,,,,,,1.05888,0.8782440161705017,,-0.21302136814020148,,0.4229293159298993,,Neutral,Neutral,,Neutral,0.12562054738933834,,0.1354587553967949,0.67664,,-0.7850606854141651,,-0.054210342707082526,,Neutral,,Neutral,,0.17490408322500473,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.5144,0.0212,-22.2302,-7.96890002094704,0.841537629757133,Pathogenic,0.9992,pathogenic,-4.906,available,https://doi.org/10.1101/2022.10.22.513328 +C275K,NP_000537:p.Cys275Lys,,,,,saturation_mutlist,,,,,,,,3.88609,1.8595277881622314,,4.372152037760791,,4.1291210188803955,,Destabilizing,Uncertain,,Destabilizing,0.24015809268260652,,0.19542970713820085,0.28171,,0.07838404585807941,,0.1800470229290397,,Neutral,,Neutral,,0.5463808192888435,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.586,0.0212,-22.2302,-7.96890002094704,0.8461548583981611,Pathogenic,1.0,pathogenic,-4.922,available,https://doi.org/10.1101/2022.10.22.513328 +C275L,NP_000537:p.Cys275Leu,,,,,saturation_mutlist,,,,,,,,0.75104,0.8437007331848144,,0.10249991910648067,,0.4267699595532404,,Neutral,Neutral,,Neutral,0.18039940530197274,,0.27839247309510967,0.51411,,-1.0577879970649027,,-0.27183899853245136,,Neutral,,Neutral,,0.32333509135461536,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.4796,0.0212,-8.9424,-7.96890002094704,0.8673183566585454,Pathogenic,0.9964,pathogenic,-4.773,available,https://doi.org/10.1101/2022.10.22.513328 +C275M,NP_000537:p.Cys275Met,,,,,saturation_mutlist,,,,,,,,1.41682,0.8085424709320068,,0.7688346751651514,,1.0928273375825757,,Neutral,Neutral,,Neutral,0.10531985495140408,,0.28515972611908635,0.1635,,-0.6468188865941634,,-0.24165944329708172,,Neutral,,Neutral,,0.1885790031419212,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.5147,0.0212,-22.2302,-7.96890002094704,0.8399726243444124,Pathogenic,0.9981,pathogenic,-4.938,available,https://doi.org/10.1101/2022.10.22.513328 +C275N,NP_000537:p.Cys275Asn,,,,,saturation_mutlist,,,,,,,,1.7348,1.6901526188850402,,1.1561766375348494,,1.4454883187674246,,Neutral,Uncertain,,Neutral,0.22596517166337018,,0.15872434253120377,0.41496,,-0.08120407100590514,,0.16687796449704742,,Neutral,,Neutral,,0.35578989971720026,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.5402,0.0212,-22.2302,-7.96890002094704,0.8694492032097283,Pathogenic,0.9995,pathogenic,-4.896,available,https://doi.org/10.1101/2022.10.22.513328 +C275P,NP_000537:p.Cys275Pro,,,,,saturation_mutlist,,,,,,,,5.6855,2.401099433898926,,5.5578911329195435,,5.621695566459772,,Destabilizing,Destabilizing,,Destabilizing,0.2339982412197606,,0.5157584616997634,4.82177,,3.7403823100192253,,4.281076155009613,,Destabilizing,,Destabilizing,,0.40636034648282554,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,uncertain,,-0.6088,0.0212,-22.2302,-7.96890002094704,0.8633991065754671,Pathogenic,0.9996,pathogenic,-5.016,available,https://doi.org/10.1101/2022.10.22.513328 +C275Q,NP_000537:p.Cys275Gln,,,,,saturation_mutlist,,,,,,,,2.81033,1.563427243232727,,1.5207345787383184,,2.165532289369159,,Uncertain,Uncertain,,Uncertain,0.18148939185023896,,0.2987884916636967,0.69764,,-0.057180278793030566,,0.32022986060348474,,Neutral,,Neutral,,0.25716957391369455,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.5642,0.0212,-22.2302,-7.96890002094704,0.8429931487764635,Pathogenic,0.9998,pathogenic,-4.914,available,https://doi.org/10.1101/2022.10.22.513328 +C275R,NP_000537:p.Cys275Arg,"hg19,17:g.7577115A>G, hg19,17:g.7673797A>G, hg38,17:g.7673797A>G",,,0.962,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376584,Conflicting classifications of pathogenicity,1,,,,,3.60003,1.799808020591736,2.6151933333333335,3.258005882847128,3.1076116666666667,3.429017941423564,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.30492890236164827,0.3037897910653938,0.23719010076674826,0.49705,0.75703,-0.36964004584557447,0.62704,0.06370497707721276,Neutral,Neutral,Neutral,Neutral,0.6805519179803012,0.4245645130571141,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.5428,0.0212,-22.2302,-7.96890002094704,0.8685728591927009,Pathogenic,0.9995,pathogenic,-4.7,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C275S,NP_000537:p.Cys275Ser,"hg19,17:g.7577114C>G, hg19,17:g.7577115A>T, hg19,17:g.7673796C>G, hg38,17:g.7673796C>G, hg38,17:g.7673797A>T",,,"0.965, 0.982","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","960924, 376583","Uncertain significance, Conflicting classifications of pathogenicity","1, 1",,,,,0.81934,0.6894899988174439,0.6306133333333334,1.5178682998537438,0.7249766666666666,1.168604149926872,Neutral,Neutral,Neutral,Neutral,Neutral,0.2858910785636807,0.17143021210458273,0.1520788285185176,0.02548,0.6642866666666667,0.31308383578867727,0.3448833333333333,0.16928191789433863,Neutral,Neutral,Neutral,Neutral,0.07096681963346593,0.4709668332696638,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.4813,0.0212,-22.2302,-4.46041556087988,0.8168382547942192,Pathogenic,0.9933,pathogenic,-4.21,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C275T,NP_000537:p.Cys275Thr,,,,,saturation_mutlist,,,,,,,,1.17,0.4493924927711487,,0.522449460396022,,0.846224730198011,,Neutral,Neutral,,Neutral,0.2777490675471827,,0.05805869147486588,-0.14994,,-0.062006129924515596,,-0.10597306496225779,,Neutral,,Neutral,,0.22836338792135466,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.516,0.0212,-22.2302,-4.78341883513615,0.862664846113737,Pathogenic,0.9968,pathogenic,-4.806,available,https://doi.org/10.1101/2022.10.22.513328 +C275V,NP_000537:p.Cys275Val,,,,,saturation_mutlist,,,,,,,,0.28284,0.25695539236068726,,-0.4260876315245739,,-0.07162381576228696,,Neutral,Neutral,,Neutral,0.2953454664821775,,0.06992821053015118,0.01849,,-0.690285946378019,,-0.3358979731890095,,Neutral,,Neutral,,0.1907732607892947,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.5124,0.0212,-22.2302,-7.96890002094704,0.8551819140281529,Pathogenic,0.9958,pathogenic,-4.716,available,https://doi.org/10.1101/2022.10.22.513328 +C275W,NP_000537:p.Cys275Trp,"hg19,17:g.7577113A>C, hg19,17:g.7673795A>C, hg38,17:g.7673795A>C",,,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",485044,Likely pathogenic,1,,,,,11.06764,1.4550135612487793,2.628686666666667,2.970025441754181,6.848163333333334,7.018832720877091,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.1889122204044055,0.9324862742272522,0.7128888036129081,1.74312,1.0138333333333334,-0.7020161637148083,1.3784766666666668,0.5205519181425958,Neutral,Neutral,Neutral,Neutral,0.7420001111560265,0.2876662558790224,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.4876,0.0212,-22.2302,-7.96890002094704,0.864854623485108,Pathogenic,0.9994,pathogenic,-4.81,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C275Y,NP_000537:p.Cys275Tyr,"hg19,17:g.7577114C>T, hg19,17:g.7673796C>T, hg38,17:g.7673796C>T",3.186336987e-05,,0.972,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",215997,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,8.83124,1.2295425057411193,2.46814,2.588857051495719,5.64969,5.710048525747859,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.18138526610591793,0.2951732387372993,0.7674381197340603,0.91809,0.3112233333333333,-0.3430826796164168,0.6146566666666666,0.2875036601917916,Neutral,Neutral,Neutral,Neutral,0.5761832729455292,0.17661704919941504,2.181,1.98,17.32,7.352,,False,2.181,,neutral,neutral,neutral,,False,17.32,,neutral,neutral,neutral,damaging,,-0.4938,0.0212,-22.2302,-7.96890002094704,0.843600373546457,Pathogenic,0.9996,pathogenic,-4.683,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276C,NP_000537:p.Ala276Cys,,,,,saturation_mutlist,,,,,,,,0.18282,-0.48537636518478394,,0.769540610474461,,0.4761803052372305,,Neutral,Neutral,,Neutral,0.15906085755482105,,0.14737537850719667,0.17263,,0.5606052388979793,,0.36661761944898963,,Neutral,,Neutral,,0.144913666180957,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.3336,0.0749,-22.2273,-4.32255694953662,0.7431236801579275,Pathogenic,0.9743,pathogenic,-4.132,available,https://doi.org/10.1101/2022.10.22.513328 +A276D,NP_000537:p.Ala276Asp,"hg19,17:g.7577110_7577111delinsAT, hg19,17:g.7577111G>T, hg19,17:g.7673793G>T, hg38,17:g.7673792_7673793delinsAT, hg38,17:g.7673793G>T",,,0.951,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",232683,Conflicting classifications of pathogenicity,1,Uncertain significance,1,Tier I - Strong,1,-0.48034,-0.21276042342185975,-0.81236,-0.18450527078471723,-0.64635,-0.3324226353923586,Neutral,Neutral,Neutral,Neutral,Neutral,0.16660077782763247,0.5606971325650477,0.28257760681873306,-0.57486,-0.50193,-0.37043821856977655,-0.538395,-0.4726491092848883,Neutral,Neutral,Neutral,Neutral,0.49646678579739856,0.1319475931854959,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.4154,0.0749,-22.2273,-7.37168848391084,0.779089296744687,Pathogenic,0.9993,pathogenic,-4.498,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276E,NP_000537:p.Ala276Glu,,,,,saturation_mutlist,,,,,,,,-0.67872,-0.4135895705223083,,-0.33740099433309,,-0.508060497166545,,Neutral,Neutral,,Neutral,0.13252083911405388,,0.24793177699113808,-0.69813,,-0.4389641432534102,,-0.5685470716267051,,Neutral,,Neutral,,0.10646635378610166,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.3332,0.0749,-8.9394,-7.37168848391084,0.8670653390220142,Pathogenic,0.9987,pathogenic,-4.61,available,https://doi.org/10.1101/2022.10.22.513328 +A276F,NP_000537:p.Ala276Phe,"hg19,17:g.7577111_7577112delinsAA, hg38,17:g.7673793_7673794delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.66864,-0.116826593875885,-0.6980733333333333,-0.4442229445887362,-0.6833566666666666,-0.5564314722943681,Neutral,Neutral,Neutral,Neutral,Neutral,0.2290263842564758,0.35086997518865715,0.05671733085839083,-0.36132,-0.33605666666666667,-0.3039798148702669,-0.3486883333333333,-0.33264990743513345,Neutral,Neutral,Neutral,Neutral,0.7385716127920313,0.07766634686909037,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.3837,0.0749,-22.2273,-7.62748751942468,0.8665935834863054,Pathogenic,0.9806,pathogenic,-4.62,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276G,NP_000537:p.Ala276Gly,"hg19,17:g.7577111G>C, hg19,17:g.7673793G>C, hg38,17:g.7673793G>C",,,0.930,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",185319,Pathogenic/Likely pathogenic,2,,,,,0.20024,0.41311532258987427,0.7377566666666667,0.6343286501675992,0.46899833333333335,0.4172843250837996,Neutral,Neutral,Neutral,Neutral,Neutral,0.07919999977449914,0.019292729776323063,0.21980837974315742,0.17834,0.5707466666666666,0.36863293389697543,0.37454333333333334,0.2734864669484877,Neutral,Neutral,Neutral,Neutral,0.16398136587903991,0.08708298673919312,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,uncertain,,-0.3271,0.0749,-22.2273,-7.62748751942468,0.8609790103964514,Pathogenic,0.9785,pathogenic,-4.232,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276H,NP_000537:p.Ala276His,,,,,saturation_mutlist,,,,,,,,-0.00578,-0.26893789291381837,,-0.40639690022042396,,-0.20608845011021198,,Neutral,Neutral,,Neutral,0.1623041109422225,,0.15295449558382804,0.07212,,-0.4678464875582174,,-0.1978632437791087,,Neutral,,Neutral,,0.09981204796079872,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.3879,0.0749,-22.2273,-7.62748751942468,0.8625555034834216,Pathogenic,0.9944,pathogenic,-4.617,available,https://doi.org/10.1101/2022.10.22.513328 +A276I,NP_000537:p.Ala276Ile,,,,,saturation_mutlist,,,,,,,,-0.39469,-0.21585809111595153,,-0.34793175609257315,,-0.3713108780462866,,Neutral,Neutral,,Neutral,0.18335119611469472,,0.07332169042162591,0.05668,,-0.25889016972298556,,-0.10110508486149278,,Neutral,,Neutral,,0.13180571092653978,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.3733,0.0749,-22.2273,-7.62748751942468,0.8708296571353376,Pathogenic,0.9955,pathogenic,-4.443,available,https://doi.org/10.1101/2022.10.22.513328 +A276K,NP_000537:p.Ala276Lys,,,,,saturation_mutlist,,,,,,,,-0.64549,0.04391197919845581,,-0.20114928509253038,,-0.4233196425462652,,Neutral,Neutral,,Neutral,0.0739088924525063,,0.14056481215194908,-0.18954,,-0.3059178498906702,,-0.2477289249453351,,Neutral,,Neutral,,0.1360856134679739,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.4057,0.0749,-22.2273,-6.90936883801731,0.5828304348554479,Uncertain,0.9985,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +A276L,NP_000537:p.Ala276Leu,,,,,saturation_mutlist,,,,,,,,-0.76509,-0.1955300509929657,,-0.5598070258101439,,-0.6624485129050719,,Neutral,Neutral,,Neutral,0.14698844126623764,,0.05469997653904143,-0.0738,,-0.5388054002597089,,-0.30630270012985444,,Neutral,,Neutral,,0.08908307508998169,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.378,0.0749,-22.2273,-7.62748751942468,0.8707002109512268,Pathogenic,0.9671,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +A276M,NP_000537:p.Ala276Met,,,,,saturation_mutlist,,,,,,,,-0.60716,-0.028680423498153668,,-0.23911150263069833,,-0.4231357513153492,,Neutral,Neutral,,Neutral,0.14931577645712724,,0.10651999823896327,-0.10892,,-0.21395233424183233,,-0.16143616712091616,,Neutral,,Neutral,,0.08933040093316207,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.3368,0.0749,-22.2273,-7.62748751942468,0.8686092729405677,Pathogenic,0.9931,pathogenic,-4.514,available,https://doi.org/10.1101/2022.10.22.513328 +A276N,NP_000537:p.Ala276Asn,,,,,saturation_mutlist,,,,,,,,-0.08321,-0.23612207531929016,,-0.035062419156058934,,-0.05913620957802947,,Neutral,Neutral,,Neutral,0.16976408013991182,,0.19080399515902854,-0.05173,,-0.15983615627892275,,-0.10578307813946138,,Neutral,,Neutral,,0.12249105755771333,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.3857,0.0749,-22.2273,-7.37168848391084,0.8697210431541887,Pathogenic,0.9931,pathogenic,-4.492,available,https://doi.org/10.1101/2022.10.22.513328 +A276P,NP_000537:p.Ala276Pro,"hg19,17:g.7577112C>G, hg19,17:g.7673794C>G, hg38,17:g.7673794C>G",,,0.949,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428893,Conflicting classifications of pathogenicity,1,,,,,-0.37838,1.0087741529941558,0.37812,1.5596395316243319,-0.00012999999999999123,0.590629765812166,Neutral,Neutral,Uncertain,Neutral,Neutral,0.37373241296385096,0.8748082960664392,0.8184125703955826,-0.98026,-0.5099766666666666,0.4697527268271479,-0.7451183333333333,-0.2552536365864261,Neutral,Neutral,Neutral,Neutral,0.33014924971728904,0.20047296824056277,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.4551,0.0749,-22.2273,-7.62748751942468,0.8610490359156022,Pathogenic,0.9913,pathogenic,-4.348,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276Q,NP_000537:p.Ala276Gln,,,,,saturation_mutlist,,,,,,,,-0.55898,-0.1480662715435028,,0.049268056329941946,,-0.25485597183502906,,Neutral,Neutral,,Neutral,0.11626847397172664,,0.19397998424584242,-0.17575,,-0.11538869953490159,,-0.14556934976745078,,Neutral,,Neutral,,0.08464547077625971,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.3832,0.0749,-22.2273,-7.37168848391084,0.8535416890561107,Pathogenic,0.9881,pathogenic,-4.515,available,https://doi.org/10.1101/2022.10.22.513328 +A276R,NP_000537:p.Ala276Arg,,,,,saturation_mutlist,,,,,,,,-0.40262,0.07447226285934447,,-0.31679860617660904,,-0.3597093030883045,,Neutral,Neutral,,Neutral,0.06987025047271984,,0.07258781688249379,-0.22808,,-0.3797946783176311,,-0.30393733915881554,,Neutral,,Neutral,,0.14265520923249175,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.4164,0.0749,-22.2273,-6.1688153241086,0.442732348773676,Uncertain,0.9704,pathogenic,-4.34,available,https://doi.org/10.1101/2022.10.22.513328 +A276S,NP_000537:p.Ala276Ser,"hg19,17:g.7577112C>A, hg38,17:g.7673794C>A",,,0.850,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.05236,-0.2118128001689911,-0.4654200000000001,0.028964153351139593,-0.20653000000000005,0.04066207667556979,Neutral,Neutral,Neutral,Neutral,Neutral,0.09422737866070725,0.5632773811069167,0.2507808355277629,0.1085,0.013606666666666668,-0.14692310507966302,0.061053333333333334,-0.019211552539831513,Neutral,Neutral,Neutral,Neutral,0.03136589903417758,0.12992948990446246,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,uncertain,,-0.2983,0.0749,-22.2273,-3.61938748631823,0.0571987258257134,Benign,0.6879,pathogenic,-3.496,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276T,NP_000537:p.Ala276Thr,"hg19,17:g.7577112C>T, hg38,17:g.7673794C>T",,,0.928,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",827547,Uncertain significance,2,,,,,0.17663,-0.41181055068969724,-0.4903633333333333,-0.03892300491732944,-0.15686666666666665,0.06885349754133528,Neutral,Neutral,Neutral,Neutral,Neutral,0.22227066486988167,0.39104279870907,0.12069854102603238,0.04868,0.13186,-0.17870894501262594,0.09027,-0.06501447250631297,Neutral,Neutral,Neutral,Neutral,0.2094411346098628,0.14573798447228334,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.2284,0.0749,-7.3546,-1.74589151428764,0.0241303041126006,Benign,0.97,pathogenic,-3.594,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276V,NP_000537:p.Ala276Val,"hg19,17:g.7577111G>A, hg38,17:g.7673793G>A",,,0.934,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3893198,Uncertain significance,1,,,,,-0.01109,-0.3161845016479492,-0.42766333333333334,-0.21130059222807507,-0.21937666666666666,-0.11119529611403753,Neutral,Neutral,Neutral,Neutral,Neutral,0.18852204666144623,0.2647337966503122,0.06757522048602371,0.21524,0.03027333333333332,-0.17928744145356182,0.12275666666666665,0.017976279273219084,Neutral,Neutral,Neutral,Neutral,0.18471458241177266,0.14919252028275998,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.3013,0.0749,-22.2273,-7.62748751942468,0.8621398981845383,Pathogenic,0.9902,pathogenic,-4.226,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276W,NP_000537:p.Ala276Trp,,,,,saturation_mutlist,,,,,,,,-0.35011,-0.04684226632118225,,-0.8524151604240631,,-0.6012625802120315,,Neutral,Neutral,,Neutral,0.21142566434829071,,0.0810434197406186,-0.12734,,-0.6734586863241413,,-0.40039934316207065,,Neutral,,Neutral,,0.08346831797605103,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.3947,0.0749,-22.2273,-7.62748751942468,0.8580265128595761,Pathogenic,0.9977,pathogenic,-4.813,available,https://doi.org/10.1101/2022.10.22.513328 +A276Y,NP_000537:p.Ala276Tyr,"hg19,17:g.7577111_7577112delinsTA",,,,"cBioPortal,saturation_mutlist",,,,,,,,-0.58201,-0.14113179206848142,,-0.39595020441037904,,-0.4889801022051895,,Neutral,Neutral,,Neutral,0.22892126170084223,,0.083205834673601,-0.31643,,-0.24668928932151923,,-0.2815596446607596,,Neutral,,Neutral,,0.08164380151750886,44.705,9.069,96.92,10.012,,False,44.705,,neutral,neutral,neutral,,False,96.92,,neutral,neutral,neutral,neutral,,-0.4029,0.0749,-22.2273,-7.62748751942468,0.8470975870481166,Pathogenic,0.994,pathogenic,-4.698,available,https://doi.org/10.1101/2022.10.22.513328 +C277A,NP_000537:p.Cys277Ala,,,,,saturation_mutlist,,,,,,,,0.18954,0.736185438632965,,-0.12269286229027176,,0.03342356885486411,,Neutral,Neutral,,Neutral,0.10245581375605184,,0.10446863911157725,0.01546,,-0.2795944582228188,,-0.13206722911140942,,Neutral,,Neutral,,0.17324219524488302,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,uncertain,,-0.4905,0.0212,-22.2302,-4.78540406810362,0.8648400057600738,Pathogenic,0.9938,pathogenic,-4.758,available,https://doi.org/10.1101/2022.10.22.513328 +C277D,NP_000537:p.Cys277Asp,,,,,saturation_mutlist,,,,,,,,-1.09736,0.12657163858413695,,-0.1674992338521606,,-0.6324296169260802,,Neutral,Neutral,,Neutral,0.10781032777705984,,0.11772994048910879,-0.53091,,-0.4313417037137355,,-0.48112585185686774,,Neutral,,Neutral,,0.3036830003499206,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,uncertain,,-0.5978,0.0212,-22.2302,-7.97190875216479,0.8707467756957098,Pathogenic,0.9997,pathogenic,-4.91,available,https://doi.org/10.1101/2022.10.22.513328 +C277E,NP_000537:p.Cys277Glu,,,,,saturation_mutlist,,,,,,,,-0.43943,0.3750893068313599,,-0.3542267077768475,,-0.39682835388842375,,Neutral,Neutral,,Neutral,0.09310660718776168,,0.06300998972278349,-0.24255,,-0.4855810042146027,,-0.3640655021073014,,Neutral,,Neutral,,0.20420885773647493,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.5854,0.0212,-22.2302,-7.97190875216479,0.870657806878097,Pathogenic,1.0,pathogenic,-4.952,available,https://doi.org/10.1101/2022.10.22.513328 +C277F,NP_000537:p.Cys277Phe,"hg19,17:g.7577108C>A, hg19,17:g.7673790C>A, hg38,17:g.7673790C>A",,3.9791809254e-06,0.932,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458567,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,-0.67209,0.2966572546958923,-0.87857,-1.0273716556365624,-0.77533,-0.8497308278182811,Neutral,Neutral,Neutral,Neutral,Neutral,0.09105966573330529,0.07468015175846034,0.21646961570016165,-0.68076,-2.5795933333333334,-1.4183578135877972,-1.6301766666666668,-1.0495589067938986,Uncertain,Neutral,Neutral,Neutral,1.2067045539079655,0.24375026392485943,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.4845,0.0212,-22.2302,-7.70457574756643,0.8083957364099436,Pathogenic,0.9904,pathogenic,-4.687,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C277G,NP_000537:p.Cys277Gly,"hg19,17:g.7577109A>C, hg19,17:g.7673791A>C, hg38,17:g.7673791A>C",,,0.846,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2757236,Likely pathogenic,3,,,,,0.61611,1.2697215175628662,4.173016666666667,0.7648673232588972,2.3945633333333336,0.6904886616294486,Uncertain,Neutral,Uncertain,Uncertain,Neutral,0.09159692310166115,0.2822377127332365,0.10893833001561985,-0.2587,1.28764,0.5899439251320702,0.51447,0.1656219625660351,Neutral,Neutral,Neutral,Neutral,1.819892518144959,0.31757825414309293,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,uncertain,,-0.483,0.0212,-22.2302,-7.97190875216479,0.8693743415061225,Pathogenic,0.9972,pathogenic,-4.766,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C277H,NP_000537:p.Cys277His,,,,,saturation_mutlist,,,,,,,,-0.09988,0.24707156419754026,,-0.7640657786952749,,-0.43197288934763745,,Neutral,Neutral,,Neutral,0.06513019327060694,,0.03133770238511449,0.06424,,-1.0475011037172475,,-0.49163055185862375,,Neutral,,Neutral,,0.27055486792664196,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.5962,0.0212,-22.2302,-7.70457574756643,0.867215154591214,Pathogenic,0.9994,pathogenic,-4.84,available,https://doi.org/10.1101/2022.10.22.513328 +C277I,NP_000537:p.Cys277Ile,,,,,saturation_mutlist,,,,,,,,-0.3994,0.5056427001953125,,-0.9664065515423509,,-0.6829032757711755,,Neutral,Neutral,,Neutral,0.160458077350396,,0.14889341614627918,0.76197,,-1.132005585736591,,-0.18501779286829545,,Neutral,,Neutral,,0.12295759467617345,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.5144,0.0212,-22.2302,-7.54819596467128,0.8691365152985879,Pathogenic,0.9977,pathogenic,-4.951,available,https://doi.org/10.1101/2022.10.22.513328 +C277K,NP_000537:p.Cys277Lys,,,,,saturation_mutlist,,,,,,,,-0.28979,0.7530855870246888,,-0.25599796415113935,,-0.2728939820755697,,Neutral,Neutral,,Neutral,0.06819582014921217,,0.0045947443761280874,-0.01992,,-0.36116030682228883,,-0.19054015341114441,,Neutral,,Neutral,,0.3172610670701737,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.586,0.0212,-22.2302,-7.97190875216479,0.8675805980733972,Pathogenic,1.0,pathogenic,-4.942,available,https://doi.org/10.1101/2022.10.22.513328 +C277L,NP_000537:p.Cys277Leu,,,,,saturation_mutlist,,,,,,,,-0.36488,0.3710663080215454,,-1.0787668789221037,,-0.7218234394610519,,Neutral,Neutral,,Neutral,0.0576228979810916,,0.13493478179047577,-0.23986,,-1.41544754404147,,-0.827653772020735,,Neutral,,Neutral,,0.1286207217145288,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.5474,0.0212,-22.2302,-7.16571991800992,0.8192528359533231,Pathogenic,0.9962,pathogenic,-4.748,available,https://doi.org/10.1101/2022.10.22.513328 +C277M,NP_000537:p.Cys277Met,,,,,saturation_mutlist,,,,,,,,-0.47967,0.5475935387611389,,-0.6787034403050914,,-0.5791867201525457,,Neutral,Neutral,,Neutral,0.06128963181559427,,0.05898093807802027,-0.47552,,-0.9006727909531115,,-0.6880963954765558,,Neutral,,Neutral,,0.0994148074972935,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.5147,0.0212,-22.2302,-7.54819596467128,0.8695825992142854,Pathogenic,0.9974,pathogenic,-4.974,available,https://doi.org/10.1101/2022.10.22.513328 +C277N,NP_000537:p.Cys277Asn,,,,,saturation_mutlist,,,,,,,,-0.37467,0.0723683953285217,,-0.3651982713910673,,-0.3699341356955337,,Neutral,Neutral,,Neutral,0.07534678044071737,,0.04789892721138611,-0.1886,,-0.48638341231615945,,-0.3374917061580797,,Neutral,,Neutral,,0.3307318850572829,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.5402,0.0212,-22.2302,-7.97190875216479,0.7881311698230675,Pathogenic,0.9989,pathogenic,-4.658,available,https://doi.org/10.1101/2022.10.22.513328 +C277P,NP_000537:p.Cys277Pro,,,,,saturation_mutlist,,,,,,,,2.19057,2.227288842201233,,3.665367589360003,,2.9279687946800017,,Uncertain,Destabilizing,,Uncertain,0.1838825710345699,,0.7323244341172168,2.21192,,1.2985090008465852,,1.7552145004232926,,Uncertain,,Neutral,,0.40581303202982133,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,uncertain,,-0.6088,0.0212,-22.2302,-7.97190875216479,0.8708173629933158,Pathogenic,0.9995,pathogenic,-4.958,available,https://doi.org/10.1101/2022.10.22.513328 +C277Q,NP_000537:p.Cys277Gln,,,,,saturation_mutlist,,,,,,,,-0.08372,0.5846458649635315,,-0.30638127252684716,,-0.1950506362634236,,Neutral,Neutral,,Neutral,0.06526423533502315,,0.03945827481526916,-0.26811,,-0.37716059027290855,,-0.3226352951364543,,Neutral,,Neutral,,0.12272387209327627,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.5642,0.0212,-22.2302,-7.97190875216479,0.8568193959087241,Pathogenic,0.9999,pathogenic,-4.984,available,https://doi.org/10.1101/2022.10.22.513328 +C277R,NP_000537:p.Cys277Arg,"hg19,17:g.7577109A>G, hg38,17:g.7673791A>G",,,0.889,"COSMIC,ClinVar,saturation_mutlist",421804,Uncertain significance,3,,,,,-0.30456,0.7018467020988465,-0.18027,-0.5895467845807607,-0.242415,-0.4470533922903803,Neutral,Neutral,Neutral,Neutral,Neutral,0.0897915818868521,0.033192753225164476,0.13108165274122965,-0.13529,-1.8172333333333333,-0.6659824243985335,-0.9762616666666666,-0.40063621219926676,Neutral,Neutral,Neutral,Neutral,1.2739252599827913,0.27240337194211894,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.5428,0.0212,-22.2302,-7.97190875216479,0.8673125779722324,Pathogenic,0.9996,pathogenic,-4.82,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C277S,NP_000537:p.Cys277Ser,"hg19,17:g.7577108C>G, hg19,17:g.7577109A>T, hg38,17:g.7673790C>G",,,"0.894, 0.936","cBioPortal,COSMIC,ClinVar,saturation_mutlist",655556,Uncertain significance,2,,,,,0.17231,0.5040941047668457,0.26859333333333335,0.1536114651531206,0.22045166666666666,0.1629607325765603,Neutral,Neutral,Neutral,Neutral,Neutral,0.09029948602961918,0.1995749679248934,0.057881964322704094,0.22144,-1.6041966666666667,-0.11245355004101752,-0.6913783333333333,0.05449322497949124,Neutral,Neutral,Neutral,Neutral,1.4624468557713661,0.29370572900776226,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,uncertain,,-0.4813,0.0212,-22.2302,-3.66742459155775,0.0938480296448164,Benign,0.9837,pathogenic,-4.213,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C277T,NP_000537:p.Cys277Thr,,,,,saturation_mutlist,,,,,,,,-0.04307,0.46961670875549316,,-0.1824208585684535,,-0.11274542928422675,,Neutral,Neutral,,Neutral,0.11565368133656098,,0.0718723196732424,0.83922,,-0.3389267446430746,,0.2501466276784627,,Neutral,,Neutral,,0.22022373755818717,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.516,0.0212,-22.2302,-4.71524399892311,0.8254853971127278,Pathogenic,0.9978,pathogenic,-4.725,available,https://doi.org/10.1101/2022.10.22.513328 +C277V,NP_000537:p.Cys277Val,,,,,saturation_mutlist,,,,,,,,0.07583,0.5014986658096313,,-0.78503138985337,,-0.354600694926685,,Neutral,Neutral,,Neutral,0.15288001022505007,,0.17047102790385138,0.77349,,-0.8642068539466634,,-0.0453584269733317,,Neutral,,Neutral,,0.16455440502872737,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.5124,0.0212,-22.2302,-7.54819596467128,0.8545103650099473,Pathogenic,0.9933,pathogenic,-4.754,available,https://doi.org/10.1101/2022.10.22.513328 +C277W,NP_000537:p.Cys277Trp,"hg19,17:g.7577107A>C, hg19,17:g.7673789A>C, hg38,17:g.7673789A>C",,,0.875,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1762926,Uncertain significance,2,,,,,-0.09878,0.46389324426651,-0.6668966666666667,-1.3716805983222218,-0.38283833333333334,-0.7352302991611109,Neutral,Neutral,Neutral,Neutral,Neutral,0.08560615902861277,0.28468141601134106,0.26966150482883017,-0.11295,0.05952333333333334,-1.6784980320213476,-0.02671333333333333,-0.8957240160106739,Neutral,Neutral,Neutral,Neutral,0.7692587090324179,0.20140841737252022,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.4198,0.0212,-8.9424,-7.70457574756643,0.7870712756526672,Pathogenic,0.9979,pathogenic,-4.78,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C277Y,NP_000537:p.Cys277Tyr,"hg19,17:g.7577108C>T, hg38,17:g.7673790C>T",,0.0,0.940,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",185722,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,-0.39014,0.3290820932388306,-1.5469366666666666,-0.9280296735534593,-0.9685383333333333,-0.6590848367767297,Neutral,Neutral,Neutral,Neutral,Neutral,0.06391230601465554,0.298291150872581,0.2073558309714317,-0.49199,-0.5062366666666667,-1.2222382481209895,-0.4991133333333333,-0.8571141240604947,Neutral,Neutral,Neutral,Neutral,0.8995993613579079,0.2952320227127391,41.269,5.778,49.89,16.311,,False,41.269,,neutral,neutral,neutral,,False,49.89,,neutral,neutral,neutral,neutral,,-0.4938,0.0212,-22.2302,-7.70457574756643,0.870614235976073,Pathogenic,0.9986,pathogenic,-4.676,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278A,NP_000537:p.Pro278Ala,"hg19,17:g.7577106G>C, hg19,17:g.7673788G>C, hg38,17:g.7673788G>C",,,0.958,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376645,Conflicting classifications of pathogenicity,1,,,,,2.60285,0.5545895838737488,1.59161,0.14728391895833703,2.09723,1.3750669594791685,Uncertain,Uncertain,Neutral,Uncertain,Neutral,0.5978567227654314,0.41016625759156083,0.24974052859628126,2.39854,-0.12562333333333328,0.15116981115304998,1.1364583333333333,1.274854905576525,Uncertain,Uncertain,Neutral,Neutral,1.895176271139149,0.19600541010793063,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,uncertain,,-0.3237,0.0423,-22.2302,-7.65902909566732,0.8704820659871179,Pathogenic,0.9934,pathogenic,-4.24,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278C,NP_000537:p.Pro278Cys,,,,,saturation_mutlist,,,,,,,,3.176,0.6975344157218933,,0.7068375460548125,,1.9414187730274064,,Uncertain,Neutral,,Neutral,0.35840013631584405,,0.13735438612003267,4.73428,,0.8098010612589063,,2.7720405306294533,,Uncertain,,Uncertain,,0.1450190665292784,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,uncertain,,-0.3564,0.0423,-22.2302,-7.65902909566732,0.8700050775606749,Pathogenic,0.9992,pathogenic,-4.498,available,https://doi.org/10.1101/2022.10.22.513328 +P278D,NP_000537:p.Pro278Asp,,,,,saturation_mutlist,,,,,,,,6.13011,2.0620974016189577,,1.6160912325776142,,3.873100616288807,,Uncertain,Destabilizing,,Destabilizing,0.2816173230900596,,0.21024558149908007,7.69299,,1.9235702758292839,,4.808280137914642,,Uncertain,,Destabilizing,,0.15629896582327354,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,uncertain,,-0.3823,0.0423,-22.2302,-7.924781724694,0.8628138570051465,Pathogenic,0.9999,pathogenic,-4.656,available,https://doi.org/10.1101/2022.10.22.513328 +P278E,NP_000537:p.Pro278Glu,,,,,saturation_mutlist,,,,,,,,7.0229,1.731749505996704,,1.5555613254761578,,4.2892306627380785,,Uncertain,Uncertain,,Destabilizing,0.2847814567966792,,0.182167365087958,9.60029,,2.1325969104550793,,5.8664434552275395,,Uncertain,,Destabilizing,,0.6033757703137397,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,neutral,,-0.3661,0.0423,-22.2302,-7.924781724694,0.8491091612697397,Pathogenic,0.9996,pathogenic,-4.596,available,https://doi.org/10.1101/2022.10.22.513328 +P278F,NP_000537:p.Pro278Phe,"hg19,17:g.7577105_7577106delinsAA, hg19,17:g.7673787_7673788delinsAA, hg38,17:g.7673787_7673788delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,22.63558,1.0507824158668517,10.9127,1.406783148626858,16.77414,12.02118157431343,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.37319408837701573,4.566858951759586,0.5792634728671622,34.04895,5.634583333333333,1.6016691050988918,19.841766666666665,17.825309552549445,Destabilizing,Uncertain,Destabilizing,Destabilizing,3.4133072091480754,1.324213064841576,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,neutral,,-0.3849,0.0423,-22.2302,-7.924781724694,0.8699998523803973,Pathogenic,0.9999,pathogenic,-4.449,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278G,NP_000537:p.Pro278Gly,,,,,saturation_mutlist,,,,,,,,3.93609,1.4338631463050842,,1.9360181808640844,,2.9360540904320422,,Uncertain,Uncertain,,Uncertain,0.44198820944072154,,0.1957599180354174,2.65843,,2.0049660214007567,,2.3316980107003786,,Uncertain,,Uncertain,,0.288582911181149,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,uncertain,,-0.3381,0.0423,-22.2302,-7.924781724694,0.845427609497148,Pathogenic,0.9989,pathogenic,-4.53,available,https://doi.org/10.1101/2022.10.22.513328 +P278H,NP_000537:p.Pro278His,"hg19,17:g.7577105G>T, hg19,17:g.7673787G>T, hg38,17:g.7673787G>T",,,0.950,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376646,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,16.75315,1.8838356018066407,10.598186666666665,1.451654760942082,13.675668333333334,9.102402380471041,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.38463234920260825,5.560144972722283,0.5533381150367728,27.36063,6.77188,1.8526256372293035,17.066255,14.606627818614651,Destabilizing,Uncertain,Destabilizing,Destabilizing,2.8768867298870147,1.0525784575690356,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,neutral,,-0.3625,0.0423,-22.2302,-7.924781724694,0.864473108403625,Pathogenic,0.9993,pathogenic,-4.4,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278I,NP_000537:p.Pro278Ile,,,,,saturation_mutlist,,,,,,,,5.7822,1.0003918242454528,,0.053813720268732025,,2.9180068601343656,,Uncertain,Uncertain,,Uncertain,0.38117254409022183,,0.29221204840083803,8.0626,,0.7897333786017019,,4.42616668930085,,Uncertain,,Destabilizing,,0.5263914263087163,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,neutral,,-0.3679,0.0423,-22.2302,-7.65902909566732,0.8603459980114134,Pathogenic,0.9994,pathogenic,-4.302,available,https://doi.org/10.1101/2022.10.22.513328 +P278K,NP_000537:p.Pro278Lys,,,,,saturation_mutlist,,,,,,,,10.88594,1.8718875932693482,,2.776180035739884,,6.831060017869942,,Uncertain,Uncertain,,Destabilizing,0.23316022623067667,,0.8510865337237628,14.36941,,3.520881444627765,,8.945145722313882,,Destabilizing,,Destabilizing,,1.2456905448390665,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,neutral,,-0.3578,0.0423,-22.2302,-7.924781724694,0.8668885184953741,Pathogenic,0.9995,pathogenic,-4.542,available,https://doi.org/10.1101/2022.10.22.513328 +P278L,NP_000537:p.Pro278Leu,"hg19,17:g.7577105G>A, hg19,17:g.7673787G>A, hg38,17:g.7673787G>A",,,0.940,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",232497,Pathogenic,2,,,,,6.43173,1.255713312625885,5.236846666666667,0.26791833657900876,5.834288333333333,3.3498241682895045,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.28823473104740654,2.6953868556273863,0.421570296686751,9.81716,2.74637,0.6402659460862167,6.281765,5.228712973043108,Uncertain,Uncertain,Destabilizing,Destabilizing,2.6011403669544637,0.5649264313789902,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,neutral,,-0.3047,0.0423,-8.9424,-5.65653065547344,0.3363015091277291,Uncertain,0.9972,pathogenic,-3.952,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278M,NP_000537:p.Pro278Met,,,,,saturation_mutlist,,,,,,,,6.17744,1.2937946391105652,,0.6303295058790364,,3.403884752939518,,Uncertain,Uncertain,,Destabilizing,0.29333867006325554,,0.179991179392198,9.57843,,0.8537680686812154,,5.216099034340608,,Uncertain,,Destabilizing,,0.6580122198772418,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,neutral,,-0.3234,0.0423,-22.2302,-7.65902909566732,0.8476373495340948,Pathogenic,0.9997,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328 +P278N,NP_000537:p.Pro278Asn,,,,,saturation_mutlist,,,,,,,,5.2407,1.9685971641540527,,0.7325158511880921,,2.986607925594046,,Uncertain,Uncertain,,Uncertain,0.3210940944746678,,0.1812319943657192,8.03617,,0.8934396365371965,,4.464804818268599,,Uncertain,,Destabilizing,,0.20413299854821423,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,uncertain,,-0.3505,0.0423,-22.2302,-7.924781724694,0.8679322680569956,Pathogenic,0.9998,pathogenic,-4.62,available,https://doi.org/10.1101/2022.10.22.513328 +P278Q,NP_000537:p.Pro278Gln,,,,,saturation_mutlist,,,,,,,,7.46785,1.8428030347824096,,1.0788781596160666,,4.273364079808033,,Uncertain,Uncertain,,Destabilizing,0.2889810963008343,,0.24509325007474386,10.7395,,1.4912114991365921,,6.1153557495682955,,Uncertain,,Destabilizing,,0.5506544440865303,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,neutral,,-0.3522,0.0423,-22.2302,-7.924781724694,0.8611188206831677,Pathogenic,0.9996,pathogenic,-4.352,available,https://doi.org/10.1101/2022.10.22.513328 +P278R,NP_000537:p.Pro278Arg,"hg19,17:g.7577105G>C, hg19,17:g.7673787G>C, hg38,17:g.7673787G>C",,,0.951,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376644,Conflicting classifications of pathogenicity,1,,,,,13.51953,1.9555353593826295,19.3483,2.0532614797857565,16.433915,7.786395739892878,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,0.27475817581992373,3.340797217860831,0.744818874019629,19.7839,9.489456666666667,2.8019536589624523,14.636678333333332,11.292926829481226,Destabilizing,Uncertain,Destabilizing,Destabilizing,4.17526143579324,1.2985801741762526,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,neutral,,-0.3936,0.0423,-22.2302,-7.924781724694,0.87078813850924,Pathogenic,0.9968,pathogenic,-4.502,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278S,NP_000537:p.Pro278Ser,"hg19,17:g.7577106G>A, hg19,17:g.7673788G>A, hg38,17:g.7673788G>A",,,0.963,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376642,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,4.20245,1.2938744878768922,3.4879833333333337,0.805300076446834,3.8452166666666665,2.5038750382234167,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,0.46975442836710185,0.2948203826437756,0.1786889864352003,3.3228,1.5187066666666666,1.1127026886614904,2.4207533333333333,2.217751344330745,Uncertain,Uncertain,Uncertain,Uncertain,2.0168935494357543,0.18841942883589846,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,uncertain,,-0.2556,0.0423,-8.9424,-5.02543687785345,0.3959218596441421,Uncertain,0.9988,pathogenic,-4.005,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278T,NP_000537:p.Pro278Thr,"hg19,17:g.7577106G>T, hg19,17:g.7673788G>T, hg38,17:g.7673788G>T",,,0.954,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376643,Pathogenic/Likely pathogenic,2,,,,,5.35318,1.332340099811554,2.6444466666666666,0.353708609605951,3.9988133333333336,2.8534443048029754,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.49604186042765086,0.695750205813041,0.0896159526280384,4.77024,1.5464866666666666,0.7284128703952192,3.1583633333333334,2.74932643519761,Uncertain,Uncertain,Destabilizing,Uncertain,2.0595557376342652,0.1477741260516691,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,uncertain,,-0.3356,0.0423,-22.2302,-7.65902909566732,0.8705672489414769,Pathogenic,0.9974,pathogenic,-4.266,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278V,NP_000537:p.Pro278Val,"hg19,17:g.7577105_7577106delinsAC, hg38,17:g.7673787_7673788delinsAC",,,,"cBioPortal,ClinVar,saturation_mutlist",3764814,,,Likely oncogenic,1,,,4.11722,0.7530597710609436,2.0766433333333336,-0.19564718517839955,3.0969316666666664,1.9607864074108001,Uncertain,Uncertain,Neutral,Destabilizing,Neutral,0.5079256045364398,1.3032757682172345,0.19821277000603915,5.50602,0.9028333333333335,0.19845384981983247,3.204426666666667,2.852236924909916,Uncertain,Uncertain,Destabilizing,Uncertain,2.8615826670490505,0.30576844348950233,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,neutral,,-0.3233,0.0423,-22.2302,-7.65902909566732,0.8663365565431582,Pathogenic,0.9982,pathogenic,-4.322,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278W,NP_000537:p.Pro278Trp,,,,,saturation_mutlist,,,,,,,,30.65752,1.3537304496765137,,1.8782835583724158,,16.267901779186207,,Uncertain,Uncertain,,Destabilizing,0.37244940045038577,,0.7657539235200795,49.5735,,2.400612484589581,,25.98705624229479,,Uncertain,,Destabilizing,,1.610647339517663,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,neutral,,-0.3974,0.0423,-22.2302,-7.924781724694,0.869005497673309,Pathogenic,0.9998,pathogenic,-4.684,available,https://doi.org/10.1101/2022.10.22.513328 +P278Y,NP_000537:p.Pro278Tyr,,,,,saturation_mutlist,,,,,,,,28.65498,1.3223364424705506,,2.009208176439579,,15.332094088219788,,Uncertain,Uncertain,,Destabilizing,0.3369827426552302,,0.7892551916165418,41.46229,,2.402788972708772,,21.932539486354386,,Uncertain,,Destabilizing,,1.400599618377842,2.805,2.186,0.525,0.767,,False,2.805,,neutral,neutral,neutral,,False,0.525,,neutral,neutral,neutral,neutral,,-0.3858,0.0423,-22.2302,-7.924781724694,0.861155409223958,Pathogenic,0.9998,pathogenic,-4.412,available,https://doi.org/10.1101/2022.10.22.513328 +G279A,NP_000537:p.Gly279Ala,"hg19,17:g.7577102C>G",,,0.907,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.02749,0.12558636784553528,-0.9650833333333333,0.41337773055493515,-0.49628666666666665,0.19294386527746757,Neutral,Neutral,Neutral,Neutral,Neutral,0.4663242762969192,0.39095737750069665,0.6455249928322454,2.70369,3.1339,1.9238957680124305,2.9187950000000003,2.313792884006215,Uncertain,Uncertain,Uncertain,Uncertain,0.7756672936682755,0.8607771108016331,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.3797,0.0423,-22.2302,-6.08115856665018,0.8128160749638212,Pathogenic,0.9586,pathogenic,-4.048,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G279C,NP_000537:p.Gly279Cys,,,,,saturation_mutlist,,,,,,,,0.64442,0.05779827952384948,,0.9831817410797412,,0.8138008705398706,,Neutral,Neutral,,Neutral,0.5051001462310555,,0.6266115316560052,6.84636,,3.2566287982718496,,5.051494399135924,,Destabilizing,,Destabilizing,,1.4195290133710698,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.4395,0.0423,-22.2302,-6.48575972066515,0.6938623673270732,Pathogenic,0.9923,pathogenic,-4.129,available,https://doi.org/10.1101/2022.10.22.513328 +G279D,NP_000537:p.Gly279Asp,"hg19,17:g.7577101_7577102delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,1.17205,0.2066823399066925,0.5447866666666666,0.5984674298684066,0.8584183333333333,0.8852587149342033,Neutral,Neutral,Neutral,Neutral,Neutral,0.6610743727732936,0.5569349267992526,0.7646136100133029,11.34862,13.871200000000002,4.121478519577277,12.609910000000001,7.735049259788639,Destabilizing,Destabilizing,Destabilizing,Destabilizing,5.025352420165841,2.51126440163096,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.44,0.0423,-22.2302,-7.59509316699625,0.8664744457816115,Pathogenic,0.9991,pathogenic,-4.419,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G279E,NP_000537:p.Gly279Glu,"hg19,17:g.7577101_7577102delinsTT, hg19,17:g.7577102C>T, hg19,17:g.7673783_7673784delinsTT, hg19,17:g.7673784C>T, hg38,17:g.7673783_7673784delinsTT, hg38,17:g.7673784C>T",,,0.907,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",419454,Conflicting classifications of pathogenicity,1,,,,,0.66853,0.1903112959861755,0.7180300000000001,0.7257383421594045,0.69328,0.6971341710797022,Neutral,Neutral,Neutral,Neutral,Neutral,0.777756840608521,1.7946435230986681,0.9215076294330127,12.27548,15.207483333333334,4.816360393203738,13.741481666666667,8.54592019660187,Destabilizing,Destabilizing,Destabilizing,Destabilizing,4.347128196931345,2.7132073919965882,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.4393,0.0423,-22.2302,-7.59509316699625,0.8672199239531324,Pathogenic,0.9986,pathogenic,-4.424,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G279F,NP_000537:p.Gly279Phe,,,,,saturation_mutlist,,,,,,,,1.04333,0.45187382102012635,,-0.7906533985183651,,0.12633830074081748,,Neutral,Neutral,,Neutral,0.492525002953463,,0.7465887463789816,20.00749,,4.484213145876841,,12.24585157293842,,Destabilizing,,Destabilizing,,2.4346717830043887,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.4776,0.0423,-22.2302,-7.24613300466929,0.8688080356555441,Pathogenic,0.9979,pathogenic,-4.565,available,https://doi.org/10.1101/2022.10.22.513328 +G279H,NP_000537:p.Gly279His,,,,,saturation_mutlist,,,,,,,,2.67442,0.3975800621509552,,-0.3045883853163589,,1.1849158073418207,,Uncertain,Neutral,,Neutral,0.4962276514341911,,0.7945739686504655,23.72867,,4.317491442323877,,14.02308072116194,,Destabilizing,,Destabilizing,,2.6530141942740895,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.4523,0.0423,-22.2302,-7.06864745155791,0.483925338210015,Uncertain,0.9996,pathogenic,-4.354,available,https://doi.org/10.1101/2022.10.22.513328 +G279I,NP_000537:p.Gly279Ile,,,,,saturation_mutlist,,,,,,,,1.80515,0.6328981685638427,,0.5775448419480906,,1.1913474209740453,,Neutral,Neutral,,Neutral,0.65459308034471,,1.3528927618663793,15.58244,,5.188524329737249,,10.385482164868625,,Destabilizing,,Destabilizing,,2.14092976701896,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.5233,0.0423,-22.2302,-7.06713682250735,0.8707944440096302,Pathogenic,0.996,pathogenic,-4.608,available,https://doi.org/10.1101/2022.10.22.513328 +G279K,NP_000537:p.Gly279Lys,,,,,saturation_mutlist,,,,,,,,0.91877,0.7275404965877533,,0.5265447174720771,,0.7226573587360385,,Neutral,Neutral,,Neutral,0.5877891610562027,,0.896851400228812,13.55536,,5.05187318644612,,9.30361659322306,,Destabilizing,,Destabilizing,,2.7099118636106625,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.4722,0.0423,-22.2302,-5.58710387886044,0.2107351379708033,Benign,0.9992,pathogenic,-3.683,available,https://doi.org/10.1101/2022.10.22.513328 +G279L,NP_000537:p.Gly279Leu,,,,,saturation_mutlist,,,,,,,,0.80316,0.6932178008556366,,-0.34023569259297365,,0.23146215370351317,,Neutral,Neutral,,Neutral,0.7511764185009563,,0.9188764674759395,16.18833,,4.090063165769699,,10.13919658288485,,Destabilizing,,Destabilizing,,2.514108048941974,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.4915,0.0423,-22.2302,-6.7001957639708,0.6763707451042147,Uncertain,0.9962,pathogenic,-4.215,available,https://doi.org/10.1101/2022.10.22.513328 +G279M,NP_000537:p.Gly279Met,,,,,saturation_mutlist,,,,,,,,0.34321,0.5113175547122956,,-0.2227432583400175,,0.06023337082999125,,Neutral,Neutral,,Neutral,0.5601242958628119,,0.6895799781300488,10.13363,,4.056230943063658,,7.094930471531828,,Destabilizing,,Destabilizing,,2.3702043441359932,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.4297,0.0423,-22.2302,-7.06713682250735,0.851291756465724,Pathogenic,0.9982,pathogenic,-4.485,available,https://doi.org/10.1101/2022.10.22.513328 +G279N,NP_000537:p.Gly279Asn,,,,,saturation_mutlist,,,,,,,,1.47043,0.5211644792556762,,0.0866539859942128,,0.7785419929971064,,Neutral,Neutral,,Neutral,0.533880313366467,,0.5990346336232774,11.87033,,3.136253784465538,,7.5032918922327685,,Destabilizing,,Destabilizing,,2.1765026506730334,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.4403,0.0423,-22.2302,-7.59509316699625,0.8705203265100196,Pathogenic,0.9986,pathogenic,-4.231,available,https://doi.org/10.1101/2022.10.22.513328 +G279P,NP_000537:p.Gly279Pro,,,,,saturation_mutlist,,,,,,,,0.22782,1.070279562473297,,4.030928382931486,,2.129374191465743,,Uncertain,Uncertain,,Uncertain,0.3872707988184531,,2.2545357801374872,8.09347,,7.883593901826996,,7.988531950913497,,Destabilizing,,Destabilizing,,0.6286106964783059,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.5374,0.0423,-22.2302,-7.8590713392407,0.8704625588550596,Pathogenic,0.9982,pathogenic,-4.608,available,https://doi.org/10.1101/2022.10.22.513328 +G279Q,NP_000537:p.Gly279Gln,,,,,saturation_mutlist,,,,,,,,1.0867,0.4347723710536957,,0.4875493611725301,,0.7871246805862651,,Neutral,Neutral,,Neutral,0.5856242829893461,,0.8531520086678163,12.58555,,4.408446086805913,,8.496998043402957,,Destabilizing,,Destabilizing,,2.6012920703489493,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.4432,0.0423,-22.2302,-7.43985307304706,0.7808426013179424,Pathogenic,0.9985,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328 +G279R,NP_000537:p.Gly279Arg,"hg19,17:g.7577103C>G, hg19,17:g.7577103C>T, hg19,17:g.7673785C>G, hg19,17:g.7673785C>T, hg38,17:g.7673785C>G, hg38,17:g.7673785C>T",,,0.896,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458568,Conflicting classifications of pathogenicity,1,,,,,1.3911,0.6619901192188263,1.801926666666667,-0.03720700266189717,1.5965133333333335,0.6769464986690514,Neutral,Neutral,Neutral,Neutral,Neutral,0.5414171437265378,1.9795513808492629,0.7987461991237415,13.88129,19.689,4.538654877585034,16.785145,9.209972438792517,Destabilizing,Destabilizing,Destabilizing,Destabilizing,4.089078873153055,2.71778984828466,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.3885,0.0423,-8.9424,-6.15827489133228,0.0819283186199024,Benign,0.9973,pathogenic,-3.804,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G279S,NP_000537:p.Gly279Ser,,,,,saturation_mutlist,,,,,,,,1.07296,0.2698147666454315,,0.7333262134231918,,0.9031431067115958,,Neutral,Neutral,,Neutral,0.4658872246929136,,0.6659925590427463,5.49505,,2.812108686552758,,4.153579343276379,,Uncertain,,Destabilizing,,1.3362552818559104,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.3856,0.0423,-22.2302,-5.56155463426553,0.3353339507516591,Uncertain,0.963,pathogenic,-3.826,available,https://doi.org/10.1101/2022.10.22.513328 +G279T,NP_000537:p.Gly279Thr,,,,,saturation_mutlist,,,,,,,,2.17319,0.44522770166397097,,0.8799405108689355,,1.5265652554344677,,Uncertain,Neutral,,Neutral,0.4738100246639364,,0.9716483897503331,10.2288,,4.1134871647709454,,7.171143582385472,,Destabilizing,,Destabilizing,,1.6375485374861967,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.4625,0.0423,-22.2302,-5.95161849905743,0.5147979977836531,Uncertain,0.9901,pathogenic,-4.136,available,https://doi.org/10.1101/2022.10.22.513328 +G279V,NP_000537:p.Gly279Val,"hg19,17:g.7577102C>A, hg38,17:g.7673783_7673784delinsTA, hg38,17:g.7673784C>A",,,0.937,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1434495,Uncertain significance,1,,,,,1.65589,0.5947600305080414,-0.23106333333333332,0.6710611046274754,0.7124133333333333,1.1634755523137377,Neutral,Neutral,Neutral,Neutral,Neutral,0.6313183037016121,1.4738446506180884,1.3298889491565975,12.05656,11.236963333333334,4.538260497691107,11.646761666666666,8.297410248845553,Destabilizing,Destabilizing,Destabilizing,Destabilizing,4.52856365915532,1.8665108944367155,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.4665,0.0423,-22.2302,-6.24577971419134,0.8350852190749557,Pathogenic,0.9895,pathogenic,-4.312,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G279W,NP_000537:p.Gly279Trp,"hg19,17:g.7577103C>A, hg19,17:g.7673785C>A, hg38,17:g.7673785C>A",,,0.930,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",4530243,,,,,Tier I - Strong,1,1.40417,0.32847684502601626,-0.76043,-1.0739937574364085,0.32186999999999993,0.16508812128179573,Neutral,Neutral,Neutral,Neutral,Neutral,0.5294308756675882,0.9162989669680233,0.794101352075907,24.00635,19.477436666666666,4.585319657313268,21.741893333333334,14.295834828656634,Destabilizing,Destabilizing,Destabilizing,Destabilizing,9.517880947747187,2.5440784614922802,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.4095,0.0423,-8.9424,-7.24613300466929,0.8478285313501481,Pathogenic,0.9965,pathogenic,-4.474,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G279Y,NP_000537:p.Gly279Tyr,,,,,saturation_mutlist,,,,,,,,1.22772,0.3381668841838837,,-0.6629639607019241,,0.2823780196490379,,Neutral,Neutral,,Neutral,0.5094060629989348,,0.8223892998146407,20.44772,,4.618132515925757,,12.53292625796288,,Destabilizing,,Destabilizing,,2.388455539768308,30.843,14.711,0.13,0.465,,False,30.843,,neutral,neutral,neutral,,False,0.13,,neutral,neutral,neutral,neutral,,-0.478,0.0423,-22.2302,-7.24613300466929,0.8687441905495304,Pathogenic,0.9979,pathogenic,-4.63,available,https://doi.org/10.1101/2022.10.22.513328 +R280A,NP_000537:p.Arg280Ala,,,,,saturation_mutlist,,,,,,,,0.65041,0.0628750467300415,,0.29302315350131775,,0.4717165767506589,,Neutral,Neutral,,Neutral,0.16840814626017467,,0.13804733424261764,-0.1005,,0.3541265305505828,,0.1268132652752914,,Neutral,,Neutral,,0.013441217928536822,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.4079,0.0212,-22.2302,-7.93668764215011,0.8637578640249548,Pathogenic,0.9997,pathogenic,-4.694,available,https://doi.org/10.1101/2022.10.22.513328 +R280C,NP_000537:p.Arg280Cys,,,,,saturation_mutlist,,,,,,,,1.06819,-0.12737183570861815,,1.020248573552151,,1.0442192867760753,,Neutral,Neutral,,Neutral,0.10384191949078458,,0.1145338099868502,0.44067,,1.1123579002215258,,0.776513950110763,,Neutral,,Neutral,,0.2370714026111124,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.4167,0.0212,-22.2302,-7.93668764215011,0.8562645338147119,Pathogenic,0.9993,pathogenic,-4.437,available,https://doi.org/10.1101/2022.10.22.513328 +R280D,NP_000537:p.Arg280Asp,,,,,saturation_mutlist,,,,,,,,0.61621,0.36726762890815734,,0.3756632934598984,,0.4959366467299492,,Neutral,Neutral,,Neutral,0.10917108948485088,,0.15842894088430243,-0.4438,,0.20789011824391243,,-0.11795494087804377,,Neutral,,Neutral,,0.18113033560357716,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.4989,0.0212,-22.2302,-7.93668764215011,0.8664820742787178,Pathogenic,0.9991,pathogenic,-4.851,available,https://doi.org/10.1101/2022.10.22.513328 +R280E,NP_000537:p.Arg280Glu,,,,,saturation_mutlist,,,,,,,,0.38167,0.21033193945884704,,0.07270187861624197,,0.22718593930812098,,Neutral,Neutral,,Neutral,0.1447125639985454,,0.17939819857786146,-0.26479,,0.1808445841742066,,-0.041972707912896715,,Neutral,,Neutral,,0.13202099467490946,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.4442,0.0212,-22.2302,-7.93668764215011,0.8644428520089446,Pathogenic,0.9966,pathogenic,-4.818,available,https://doi.org/10.1101/2022.10.22.513328 +R280F,NP_000537:p.Arg280Phe,,,,,saturation_mutlist,,,,,,,,0.21926,0.16281932711601257,,0.0866961696257273,,0.15297808481286365,,Neutral,Neutral,,Neutral,0.15274765129924234,,0.19437021189434922,-0.30851,,0.14253929992075787,,-0.08298535003962107,,Neutral,,Neutral,,0.13603785823126044,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.44,0.0212,-22.2302,-7.93668764215011,0.8687626312560728,Pathogenic,0.9998,pathogenic,-4.74,available,https://doi.org/10.1101/2022.10.22.513328 +R280G,NP_000537:p.Arg280Gly,"hg19,17:g.7577100T>C, hg19,17:g.7673782T>C, hg38,17:g.7673782T>C",,,0.924,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376658,Conflicting classifications of pathogenicity,1,,,Tier II - Potential,0,0.90151,0.7624800646305084,2.2060099999999996,0.979969622312063,1.5537599999999998,0.9407398111560314,Uncertain,Neutral,Neutral,Neutral,Neutral,0.21980026926529134,0.13779929922414946,0.13627291817516793,-0.58408,1.2250566666666665,0.9380821954003351,0.3204883333333332,0.17700109770016753,Neutral,Neutral,Neutral,Neutral,1.0157591737327416,0.14501437147622337,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.4432,0.0212,-22.2302,-7.93668764215011,0.8646735653565806,Pathogenic,0.9989,pathogenic,-4.627,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280H,NP_000537:p.Arg280His,,,,,saturation_mutlist,,,,,,,,0.23299,0.10938576459884641,,0.04729797437858633,,0.14014398718929316,,Neutral,Neutral,,Neutral,0.07976066800142588,,0.1768841967310175,0.36029,,-0.04188803526503007,,0.15920098236748498,,Neutral,,Neutral,,0.04723252787404122,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.3776,0.0212,-22.2302,-7.93668764215011,0.8696509098230322,Pathogenic,0.9973,pathogenic,-4.396,available,https://doi.org/10.1101/2022.10.22.513328 +R280I,NP_000537:p.Arg280Ile,"hg19,17:g.7577098_7577099delinsAA, hg19,17:g.7577099C>A, hg19,17:g.7673781C>A, hg38,17:g.7673781C>A",,,0.942,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",161517,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,0.4259,-0.22523550271987916,0.6303833333333334,-0.1115650323990186,0.5281416666666667,0.1571674838004907,Neutral,Neutral,Neutral,Neutral,Neutral,0.1961688174730747,0.3136940558711448,0.11723641328585405,-0.26808,1.3044233333333333,0.22001745535078018,0.5181716666666667,-0.0240312723246099,Neutral,Neutral,Neutral,Neutral,1.9345988926102715,0.22280836351353953,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.4373,0.0212,-22.2302,-7.93668764215011,0.8479031452221295,Pathogenic,0.9996,pathogenic,-4.721,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280K,NP_000537:p.Arg280Lys,"hg19,17:g.7577099C>T, hg19,17:g.7577099_7577101delinsTTT, hg19,17:g.7673781C>T, hg38,17:g.7673781C>T",,,0.935,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376657,Conflicting classifications of pathogenicity,1,,,,,-0.01379,-0.009369451999664295,0.6798166666666666,0.04230754059736439,0.33301333333333333,0.014258770298682196,Neutral,Neutral,Neutral,Neutral,Neutral,0.07088776991343003,0.22456463142910302,0.12753511362642614,-0.19475,0.38117666666666666,0.3158062835296967,0.09321333333333333,0.060528141764848345,Neutral,Neutral,Neutral,Neutral,0.4797794628322012,0.12309681975890248,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,uncertain,,-0.2981,0.0212,-22.2302,-4.76455912194511,0.8531094475552152,Pathogenic,0.9936,pathogenic,-4.259,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280L,NP_000537:p.Arg280Leu,"hg19,17:g.7577098_7577100delinsGAG, hg38,17:g.7673780_7673782delinsGAG",,,,"ClinVar,saturation_mutlist",1042468,Uncertain significance,1,,,,,0.13643,0.06743622303009031,0.5051033333333333,-0.2676473720221604,0.32076666666666664,-0.06560868601108019,Neutral,Neutral,Neutral,Neutral,Neutral,0.04936046999716492,0.20536307430716186,0.1043874950407319,-0.42427,-0.6454633333333333,-0.26464646421351856,-0.5348666666666666,-0.3444582321067593,Neutral,Neutral,Neutral,Neutral,0.7254912127348997,0.09818621739007952,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.4103,0.0212,-22.2302,-7.93668764215011,0.8613757826851565,Pathogenic,0.9988,pathogenic,-4.524,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280M,NP_000537:p.Arg280Met,,,,,saturation_mutlist,,,,,,,,0.41989,0.16907566785812378,,0.1161679299171231,,0.26802896495856154,,Neutral,Neutral,,Neutral,0.05492396127848142,,0.17307709886503672,-0.53797,,0.091327023730711,,-0.22332148813464447,,Neutral,,Neutral,,0.0828793229546732,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.3762,0.0212,-22.2302,-7.93668764215011,0.8584787270419894,Pathogenic,0.9999,pathogenic,-4.642,available,https://doi.org/10.1101/2022.10.22.513328 +R280N,NP_000537:p.Arg280Asn,"hg19,17:g.7577098_7577099delinsGT",,,,"cBioPortal,saturation_mutlist",,,,,,,,0.23352,0.30771252393722537,0.7267566666666667,0.282266247087444,0.48013833333333333,0.257893123543722,Neutral,Neutral,Neutral,Neutral,Neutral,0.11059928619288538,0.002156313726916591,0.10393382440615284,0.1151,0.32392333333333334,0.24008762200944797,0.21951166666666666,0.177593811004724,Neutral,Neutral,Neutral,Neutral,0.9704359281729469,0.21174302846913085,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.4228,0.0212,-22.2302,-7.93668764215011,0.8091210020521968,Pathogenic,0.9994,pathogenic,-4.71,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280P,NP_000537:p.Arg280Pro,,,,,saturation_mutlist,,,,,,,,0.45595,0.9699026429653168,6.408276666666666,3.5528695223252087,3.4321133333333327,2.0044097611626044,Uncertain,Uncertain,Neutral,Destabilizing,Uncertain,0.3817034292765789,2.987339476795736,0.6552379502702935,-0.13446,3.08651,2.1889424675353872,1.4760250000000001,1.0272412337676937,Uncertain,Uncertain,Neutral,Neutral,1.7895508826518456,1.0172144789433701,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.55,0.0212,-22.2302,-7.93668764215011,0.8594415802973296,Pathogenic,0.9992,pathogenic,-4.611,available,https://doi.org/10.1101/2022.10.22.513328 +R280Q,NP_000537:p.Arg280Gln,,,,,saturation_mutlist,,,,,,,,0.0001,0.12656123161315916,,0.3093597248923126,,0.1547298624461563,,Neutral,Neutral,,Neutral,0.09949106432096871,,0.16289633163382997,-0.208,,0.3798111118134926,,0.0859055559067463,,Neutral,,Neutral,,0.04365926509197593,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.3826,0.0212,-22.2302,-7.93668764215011,0.8694796503438023,Pathogenic,0.9983,pathogenic,-4.437,available,https://doi.org/10.1101/2022.10.22.513328 +R280S,NP_000537:p.Arg280Ser,"hg19,17:g.7577098T>A, hg19,17:g.7577098T>G, hg19,17:g.7673780T>A, hg19,17:g.7673780T>G, hg38,17:g.7673780T>A, hg38,17:g.7673780T>G",,,0.878,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","988616, 634747","Conflicting classifications of pathogenicity, Pathogenic/Likely pathogenic","1, 2",,,Tier I - Strong,0,0.74169,0.12244534254074095,1.2733566666666665,0.5221662230472428,1.0075233333333333,0.6319281115236214,Neutral,Neutral,Neutral,Neutral,Neutral,0.10960825554124762,0.1387557927519504,0.1935415505331814,0.09536,0.6960333333333333,0.43556345098306015,0.39569666666666664,0.2654617254915301,Neutral,Neutral,Neutral,Neutral,0.705521701878987,0.12317573234963441,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.3406,0.0212,-8.9424,-7.93668764215011,0.8694397785436389,Pathogenic,0.9997,pathogenic,-4.557,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280T,NP_000537:p.Arg280Thr,"hg19,17:g.7577099C>G, hg19,17:g.7673781C>G, hg38,17:g.7673781C>G",,,0.940,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12368,Pathogenic/Likely pathogenic,2,,,,,0.71305,0.2242099118232727,0.9868466666666666,0.32965118500329776,0.8499483333333333,0.5213505925016488,Neutral,Neutral,Neutral,Neutral,Neutral,0.10266448099107363,0.23102051342299074,0.19692313269180584,0.11961,0.64841,0.44038865370212027,0.38401,0.2799993268510601,Neutral,Neutral,Neutral,Neutral,0.3150963237911015,0.10839311206307342,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.4128,0.0212,-22.2302,-7.93668764215011,0.8429028653017477,Pathogenic,0.9997,pathogenic,-4.662,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280V,NP_000537:p.Arg280Val,,,,,saturation_mutlist,,,,,,,,0.71902,-0.039763894081115726,,0.033127397671357535,,0.37607369883567876,,Neutral,Neutral,,Neutral,0.1751051367162737,,0.13612895594952365,0.205,,0.3056086709468325,,0.25530433547341624,,Neutral,,Neutral,,0.10976387639337269,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.4244,0.0212,-22.2302,-7.93668764215011,0.8623034919482359,Pathogenic,0.9997,pathogenic,-4.761,available,https://doi.org/10.1101/2022.10.22.513328 +R280W,NP_000537:p.Arg280Trp,,,,,saturation_mutlist,,,,,,,,0.53789,0.23720850467681884,,-0.2955909083655513,,0.12114954581722434,,Neutral,Neutral,,Neutral,0.11654457594293727,,0.17059333523652767,-0.39463,,-0.2506506171683764,,-0.3226403085841882,,Neutral,,Neutral,,0.2154954664556267,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.4256,0.0212,-22.2302,-7.93668764215011,0.8606007292691373,Pathogenic,0.9946,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +R280Y,NP_000537:p.Arg280Tyr,,,,,saturation_mutlist,,,,,,,,0.33354,0.1061315369606018,,0.14304194840276005,,0.23829097420138,,Neutral,Neutral,,Neutral,0.12993382083766108,,0.22015158834124052,-0.25804,,0.15801151725450766,,-0.05001424137274617,,Neutral,,Neutral,,0.15706936098160942,59.817,6.503,75.4,11.95,,False,59.817,,neutral,neutral,neutral,,False,75.4,,neutral,neutral,neutral,neutral,,-0.4293,0.0212,-22.2302,-7.93668764215011,0.8671597521678513,Pathogenic,0.9991,pathogenic,-4.657,available,https://doi.org/10.1101/2022.10.22.513328 +D281A,NP_000537:p.Asp281Ala,"hg19,17:g.7577096T>G, hg19,17:g.7673778T>G, hg38,17:g.7673778T>G",,,0.977,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376589,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,1.03114,0.9021975207328796,1.988323333333333,0.9200662231989631,1.5097316666666665,0.9756031115994815,Neutral,Neutral,Neutral,Neutral,Neutral,0.788088501122908,0.5010640133644491,0.05024270487651005,-0.31456,1.0090733333333333,0.7509624964472831,0.34725666666666666,0.21820124822364154,Neutral,Neutral,Neutral,Neutral,0.49531642104371587,0.2990694890115368,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,uncertain,,-0.3368,0.1284,-22.2302,-7.47190388453418,0.8708607545954328,Pathogenic,0.9997,pathogenic,-4.602,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281C,NP_000537:p.Asp281Cys,,,,,saturation_mutlist,,,,,,,,1.43088,0.638343698978424,,1.504427054570572,,1.467653527285286,,Neutral,Neutral,,Neutral,0.564477270877911,,0.12050502541763387,0.02186,,1.2650460823353582,,0.6434530411676791,,Neutral,,Neutral,,0.27693359718689303,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,uncertain,,-0.3783,0.1284,-22.2302,-7.47190388453418,0.8646788346345183,Pathogenic,0.9999,pathogenic,-4.604,available,https://doi.org/10.1101/2022.10.22.513328 +D281E,NP_000537:p.Asp281Glu,"hg19,17:g.7577095G>C, hg19,17:g.7577095G>T, hg19,17:g.7673777G>C, hg19,17:g.7673777G>T, hg38,17:g.7673777G>C, hg38,17:g.7673777G>T",,,0.909,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","406568, 376587","Pathogenic/Likely pathogenic, Conflicting classifications of pathogenicity","2, 1","Oncogenic, Oncogenic","1, 1",Tier I - Strong,1,0.1962,0.40494951486587527,1.5399066666666668,0.5519703858386289,0.8680533333333333,0.37408519291931447,Neutral,Neutral,Neutral,Neutral,Neutral,0.6448461924793448,0.32497173788226913,0.10576752678812074,-0.4738,1.2924066666666667,0.7840237531464584,0.40930333333333335,0.15511187657322922,Neutral,Neutral,Neutral,Neutral,1.10854020484399,0.053357902959940993,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,neutral,,-0.2059,0.1284,-7.3575,-2.79266959541697,0.8605889695961217,Pathogenic,0.9991,pathogenic,-4.204,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281F,NP_000537:p.Asp281Phe,,,,,saturation_mutlist,,,,,,,,0.73729,1.2533946752548217,,0.5172256171645652,,0.6272578085822826,,Neutral,Uncertain,,Neutral,0.6506884864728409,,0.028238294651196698,-1.23843,,-0.1566826780567652,,-0.6975563390283825,,Neutral,,Neutral,,0.20082031107232987,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,neutral,,-0.437,0.1284,-22.2302,-6.86978097273434,0.8698819004403927,Pathogenic,0.9996,pathogenic,-4.808,available,https://doi.org/10.1101/2022.10.22.513328 +D281G,NP_000537:p.Asp281Gly,"hg19,17:g.7577096T>C, hg19,17:g.7673778T>C, hg38,17:g.7673778T>C",,,0.974,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141141,Pathogenic,2,,,,,2.16011,1.6142930269241333,3.9571466666666666,2.166693543904557,3.058628333333333,2.1634017719522785,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,0.7253698511442134,0.5191823575798993,0.08144533595500293,0.61684,1.9370733333333334,1.9983733893854525,1.2769566666666667,1.3076066946927263,Neutral,Neutral,Neutral,Neutral,0.410775504084111,0.314040371109173,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,uncertain,,-0.348,0.1284,-22.2302,-5.98985813599738,0.7245715624970708,Pathogenic,0.9995,pathogenic,-4.52,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281H,NP_000537:p.Asp281His,"hg19,17:g.7577097C>G, hg19,17:g.7673779C>G, hg38,17:g.7673779C>G",,,0.961,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376588,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,1.21636,1.011344211101532,1.8165533333333332,0.5642451315229268,1.5164566666666666,0.8903025657614634,Neutral,Neutral,Uncertain,Neutral,Neutral,0.6928660455395552,0.47062332937876716,0.06593100997410721,-0.03495,0.8487533333333334,0.3811065922933449,0.40690166666666666,0.17307829614667247,Neutral,Neutral,Neutral,Neutral,0.41631346766055455,0.2610259841197406,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,neutral,,-0.2703,0.1284,-7.3575,-3.99773447527279,0.0556336420513378,Benign,0.9993,pathogenic,-4.123,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281I,NP_000537:p.Asp281Ile,,,,,saturation_mutlist,,,,,,,,1.24124,1.138475967645645,,0.32848573936726505,,0.7848628696836325,,Neutral,Uncertain,,Neutral,0.6694752946502316,,0.3125594223693926,-0.74213,,-0.22621300963307292,,-0.4841715048165364,,Neutral,,Neutral,,0.16267317482149896,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,neutral,,-0.4292,0.1284,-22.2302,-7.73122410772527,0.8640388448762604,Pathogenic,0.9998,pathogenic,-4.779,available,https://doi.org/10.1101/2022.10.22.513328 +D281K,NP_000537:p.Asp281Lys,,,,,saturation_mutlist,,,,,,,,1.19249,1.700969898700714,,1.2547575229724777,,1.2236237614862389,,Neutral,Uncertain,,Neutral,0.8405591252776551,,0.3039143896181649,-0.36735,,0.8880713791077569,,0.2603606895538785,,Neutral,,Neutral,,0.27784122964005825,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,neutral,,-0.4076,0.1284,-22.2302,-7.73122410772527,0.8665698885078401,Pathogenic,0.9994,pathogenic,-4.708,available,https://doi.org/10.1101/2022.10.22.513328 +D281L,NP_000537:p.Asp281Leu,,,,,saturation_mutlist,,,,,,,,0.32983,1.27983589053154,,0.18337700759129769,,0.25660350379564884,,Neutral,Uncertain,,Neutral,0.6943202315288598,,0.1943556148349336,-1.13086,,-0.3655614014263906,,-0.7482107007131953,,Neutral,,Neutral,,0.2016559672848152,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,neutral,,-0.355,0.1284,-8.9424,-7.73122410772527,0.8685492752817807,Pathogenic,0.9996,pathogenic,-4.69,available,https://doi.org/10.1101/2022.10.22.513328 +D281M,NP_000537:p.Asp281Met,,,,,saturation_mutlist,,,,,,,,0.36922,1.1595255184173583,,0.5710987469901624,,0.4701593734950812,,Neutral,Uncertain,,Neutral,0.7009813751577433,,0.10504980450828849,-1.19134,,0.16347588591859177,,-0.5139320570407041,,Neutral,,Neutral,,0.23812495982568355,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,neutral,,-0.3616,0.1284,-22.2302,-7.73122410772527,0.8665544628478621,Pathogenic,1.0,pathogenic,-4.806,available,https://doi.org/10.1101/2022.10.22.513328 +D281N,NP_000537:p.Asp281Asn,"hg19,17:g.7577097C>T, hg19,17:g.7673779C>T, hg38,17:g.7673779C>T",,3.9771552204e-06,0.943,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376586,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,1.03468,1.0128590536117554,2.1995466666666665,0.6324507843413922,1.6171133333333332,0.8335653921706961,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.42086603009392437,0.4563584543122021,0.07558611826817964,-0.20143,0.6764166666666668,0.8092297340030475,0.2374933333333334,0.30389986700152377,Neutral,Neutral,Neutral,Neutral,0.4417541592585431,0.4078724943024796,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,uncertain,,-0.3035,0.1284,-22.2302,-4.6419709862034,0.8189711021784798,Pathogenic,0.9988,pathogenic,-4.286,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281P,NP_000537:p.Asp281Pro,"hg19,17:g.7577096_7577097delinsGG",,,,"cBioPortal,saturation_mutlist",,,,,,,,3.26656,1.412390296459198,10.24955,5.653013070015738,6.758055,4.4597865350078685,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.803091611898932,0.5006088773350577,1.0311215556861295,0.85945,8.536733333333332,4.79906621283369,4.6980916666666666,2.829258106416845,Uncertain,Uncertain,Destabilizing,Uncertain,2.927479654632785,1.2951756753569108,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,uncertain,,-0.4738,0.1284,-22.2302,-7.73122410772527,0.8537204289895848,Pathogenic,0.9998,pathogenic,-4.788,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281Q,NP_000537:p.Asp281Gln,,,,,saturation_mutlist,,,,,,,,0.95735,0.8925447678565979,,0.8089172680671983,,0.8831336340335991,,Neutral,Neutral,,Neutral,0.7181148573379574,,0.1288871642901544,-0.36545,,0.7178658111357424,,0.17620790556787122,,Neutral,,Neutral,,0.1536736197340111,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,neutral,,-0.3638,0.1284,-22.2302,-4.6419709862034,0.8708488859765695,Pathogenic,0.9997,pathogenic,-4.635,available,https://doi.org/10.1101/2022.10.22.513328 +D281R,NP_000537:p.Asp281Arg,"hg38,17:g.7673777_7673779delinsCCG",,,,"COSMIC,saturation_mutlist",,,,,,,,1.72279,1.7342897152900696,3.496256666666666,0.9524289865259487,2.609523333333333,1.3376094932629743,Uncertain,Neutral,Uncertain,Uncertain,Neutral,0.8197948199192421,0.5985173801059487,0.22771067026939074,-0.16989,1.4714299999999998,0.39972794279715335,0.6507699999999998,0.11491897139857667,Neutral,Neutral,Neutral,Neutral,0.14489023730626804,0.3490855373242856,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,neutral,,-0.4386,0.1284,-22.2302,-7.73122410772527,0.863092181505992,Pathogenic,0.9993,pathogenic,-4.829,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281S,NP_000537:p.Asp281Ser,,,,,saturation_mutlist,,,,,,,,1.94654,0.8103882265090943,,1.3289287037378819,,1.637734351868941,,Neutral,Neutral,,Neutral,0.5682333993784713,,0.1436488222597948,0.17897,,1.3388677441512067,,0.7589188720756034,,Neutral,,Neutral,,0.2931296581855614,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,uncertain,,-0.3433,0.1284,-22.2302,-7.47190388453418,0.8551576519635428,Pathogenic,0.9994,pathogenic,-4.491,available,https://doi.org/10.1101/2022.10.22.513328 +D281T,NP_000537:p.Asp281Thr,,,,,saturation_mutlist,,,,,,,,2.04803,1.2758203077316284,,0.9723973727854888,,1.5102136863927442,,Uncertain,Uncertain,,Neutral,0.729017127807035,,0.19595426633113291,-0.08929,,0.7759491385863012,,0.3433295692931506,,Neutral,,Neutral,,0.1085085967503942,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,uncertain,,-0.3733,0.1284,-22.2302,-7.47190388453418,0.8525696596801767,Pathogenic,0.9999,pathogenic,-4.538,available,https://doi.org/10.1101/2022.10.22.513328 +D281V,NP_000537:p.Asp281Val,"hg19,17:g.7577096T>A, hg19,17:g.7673778T>A, hg38,17:g.7673778T>A",,,0.969,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182968,Pathogenic/Likely pathogenic,2,,,,,1.52483,1.1615904188156128,1.03458,0.41308358793990196,1.2797049999999999,0.9689567939699509,Neutral,Neutral,Uncertain,Neutral,Neutral,0.7465553294537226,0.415899992546285,0.23545650874666335,-0.48351,0.5183666666666668,-0.08259574215151534,0.01742833333333338,-0.28305287107575766,Neutral,Neutral,Neutral,Neutral,0.8638377307624905,0.09795612144226461,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,neutral,,-0.3839,0.1284,-22.2302,-7.73122410772527,0.8618649176566013,Pathogenic,0.9997,pathogenic,-4.621,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281W,NP_000537:p.Asp281Trp,,,,,saturation_mutlist,,,,,,,,1.35701,0.990452378988266,,0.23912256770676465,,0.7980662838533823,,Neutral,Neutral,,Neutral,0.5812596935338856,,0.13250047320988312,-0.39767,,-0.5416014042966114,,-0.46963570214830574,,Neutral,,Neutral,,0.21113592402964756,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,neutral,,-0.4174,0.1284,-22.2302,-6.86978097273434,0.8708565703140422,Pathogenic,0.9998,pathogenic,-4.884,available,https://doi.org/10.1101/2022.10.22.513328 +D281Y,NP_000537:p.Asp281Tyr,"hg19,17:g.7577097C>A, hg19,17:g.7673779C>A, hg38,17:g.7673779C>A",,,0.957,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376585,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,Tier I - Strong,1,0.94303,1.1105094838142395,1.4048733333333334,0.7178707387957209,1.1739516666666667,0.8304503693978604,Neutral,Neutral,Uncertain,Neutral,Neutral,0.7370106240308725,0.5493572547582817,0.08408562806394666,-0.95099,0.30374000000000007,0.031947617128037904,-0.32362499999999994,-0.459521191435981,Neutral,Neutral,Neutral,Neutral,0.8267693271201264,0.14509722777868556,12.115,7.055,33.78,7.156,,False,12.115,,neutral,neutral,neutral,,False,33.78,,neutral,neutral,neutral,neutral,,-0.3818,0.1284,-22.2302,-6.86978097273434,0.8689228152043336,Pathogenic,0.9959,pathogenic,-4.659,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282A,NP_000537:p.Arg282Ala,,,,,saturation_mutlist,,,,,,,,1.86493,0.4945709097385407,,1.2568299720934961,,1.5608799860467482,,Neutral,Neutral,,Neutral,0.2696303805679204,,0.32636651797321486,-0.19567,,0.23931311526660495,,0.02182155763330247,,Neutral,,Neutral,,0.3170814645508585,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.4004,0.1018,-22.2244,-6.48704533042472,0.6368293163401083,Uncertain,0.99,pathogenic,-4.206,available,https://doi.org/10.1101/2022.10.22.513328 +R282C,NP_000537:p.Arg282Cys,,,,,saturation_mutlist,,,,,,,,2.17767,0.2783976459503174,,1.7675953054289426,,1.9726326527144713,,Uncertain,Neutral,,Neutral,0.2502693016648739,,0.21414436179939822,0.44831,,1.1865098576005446,,0.8174099288002723,,Neutral,,Neutral,,0.14840181098967287,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.4093,0.1018,-22.2244,-6.22849488515168,0.7500301044800224,Pathogenic,0.8702,pathogenic,-4.133,available,https://doi.org/10.1101/2022.10.22.513328 +R282D,NP_000537:p.Arg282Asp,,,,,saturation_mutlist,,,,,,,,4.14046,1.4157686972618102,,2.3784380561067286,,3.259449028053364,,Uncertain,Uncertain,,Destabilizing,0.3073488735513927,,0.18923877268997025,1.71535,,1.7437951088821606,,1.7295725544410803,,Neutral,,Neutral,,0.40734846609259673,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.4915,0.1018,-22.2244,-7.27612260805695,0.8690591042790947,Pathogenic,0.9996,pathogenic,-4.774,available,https://doi.org/10.1101/2022.10.22.513328 +R282E,NP_000537:p.Arg282Glu,,,,,saturation_mutlist,,,,,,,,3.06107,0.9610228276252747,,1.9296549218662726,,2.495362460933136,,Uncertain,Neutral,,Uncertain,0.2726692751398765,,0.34988533396523797,1.61238,,1.2301969936782573,,1.4212884968391286,,Neutral,,Neutral,,0.4977655437348319,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.4367,0.1018,-22.2244,-7.27612260805695,0.8038760709228124,Pathogenic,0.9936,pathogenic,-4.564,available,https://doi.org/10.1101/2022.10.22.513328 +R282F,NP_000537:p.Arg282Phe,,,,,saturation_mutlist,,,,,,,,3.39441,-0.005960981845855726,,0.31376894006121475,,1.8540894700306074,,Uncertain,Neutral,,Neutral,0.3317010217269984,,0.07280703779703897,-0.17067,,-0.24307762409122968,,-0.20687381204561484,,Neutral,,Neutral,,0.234637182367745,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,neutral,,-0.4326,0.1018,-22.2244,-7.0860137439162,0.7703174665281602,Pathogenic,0.9957,pathogenic,-4.581,available,https://doi.org/10.1101/2022.10.22.513328 +R282G,NP_000537:p.Arg282Gly,"hg19,17:g.7577094G>C, hg19,17:g.7673776G>C, hg38,17:g.7673776G>C",,,0.863,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",140821,Pathogenic,2,,,,,2.81483,1.1878715968132019,2.943763333333333,2.5016196485200797,2.879296666666667,2.65822482426004,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.24869045733274436,0.1618165385724078,0.2373608786909337,0.76512,1.0334466666666666,1.6271078094424591,0.8992833333333333,1.1961139047212295,Neutral,Neutral,Neutral,Neutral,0.5744982839738417,0.2657361344360808,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.368,0.1018,-8.9365,-7.68498215740767,0.8568261532349332,Pathogenic,0.9871,pathogenic,-4.498,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282H,NP_000537:p.Arg282His,"hg19,17:g.7577092_7577093delinsGT, hg38,17:g.7673774_7673775delinsAT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,4.52973,0.4743327283859253,1.43696,1.0689291796317981,2.983345,2.799329589815899,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.19061584872323661,0.29079575386629475,0.12487545101298297,0.70281,0.9432,0.4111349541399351,0.823005,0.5569724770699676,Neutral,Neutral,Neutral,Neutral,0.8085679266868472,0.24373757504101587,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.3024,0.1018,-8.9365,-7.0860137439162,0.7881515797366464,Pathogenic,0.9375,pathogenic,-4.178,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282I,NP_000537:p.Arg282Ile,,,,,saturation_mutlist,,,,,,,,1.79274,0.09831438541412353,,0.407647991912679,,1.1001939959563396,,Neutral,Neutral,,Neutral,0.4214475728696689,,0.2702277945943015,1.15559,,0.4277342880901381,,0.791662144045069,,Neutral,,Neutral,,0.5114546108599619,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.4298,0.1018,-22.2244,-5.26666468456558,0.5751960354857709,Uncertain,0.9842,pathogenic,-4.192,available,https://doi.org/10.1101/2022.10.22.513328 +R282K,NP_000537:p.Arg282Lys,,,,,saturation_mutlist,,,,,,,,0.52472,0.2156902956962585,,1.4709976963181388,,0.9978588481590693,,Neutral,Neutral,,Neutral,0.08095509030797421,,0.27394255762494696,-0.03633,,1.1193844207208015,,0.5415272103604007,,Neutral,,Neutral,,0.08765235447486792,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.2907,0.1018,-22.2244,-3.53886314041208,0.3776536064837923,Uncertain,0.8745,pathogenic,-3.643,available,https://doi.org/10.1101/2022.10.22.513328 +R282L,NP_000537:p.Arg282Leu,"hg19,17:g.7577093C>A, hg38,17:g.7673775C>A",,,0.898,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182938,Uncertain significance,3,,,,,0.42148,-0.12163828134536743,0.3700666666666667,-0.08699486211534306,0.39577333333333337,0.16724256894232847,Neutral,Neutral,Neutral,Neutral,Neutral,0.3810447583438692,0.08010707181988087,0.22454040292419833,-0.31321,-0.9879833333333333,-0.06658132659138505,-0.6505966666666667,-0.18989566329569252,Neutral,Neutral,Neutral,Neutral,0.5698439869726528,0.28166078010166307,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.33,0.1018,-7.9366,-3.79121713083018,0.0077016032094239,Benign,0.9405,pathogenic,-3.89,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282M,NP_000537:p.Arg282Met,,,,,saturation_mutlist,,,,,,,,0.76201,0.051783447265625,,0.46235873930116744,,0.6121843696505838,,Neutral,Neutral,,Neutral,0.3022297746965174,,0.27101046327772055,-0.95046,,0.2008953438398674,,-0.3747823280800663,,Neutral,,Neutral,,0.3346970253949409,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.3687,0.1018,-22.2244,-5.72845352701328,0.4400039030338756,Uncertain,0.9882,pathogenic,-4.172,available,https://doi.org/10.1101/2022.10.22.513328 +R282N,NP_000537:p.Arg282Asn,,,,,saturation_mutlist,,,,,,,,2.12102,1.116744999885559,,1.5268587957271345,,1.8239393978635672,,Uncertain,Uncertain,,Neutral,0.22480432131591924,,0.06792919972832125,0.54246,,1.1396188422818785,,0.8410394211409393,,Neutral,,Neutral,,0.16992271516025603,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.4153,0.1018,-22.2244,-7.27612260805695,0.8698712570451417,Pathogenic,0.9986,pathogenic,-4.554,available,https://doi.org/10.1101/2022.10.22.513328 +R282P,NP_000537:p.Arg282Pro,"hg19,17:g.7577092_7577093delinsGG, hg19,17:g.7577093C>G, hg19,17:g.7673775C>G, hg38,17:g.7673775C>G",,,0.911,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376659,Pathogenic/Likely pathogenic,2,,,,,7.08227,1.2629789113998413,12.14943,6.96167129020354,9.61585,7.021970645101771,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,0.2554886806553061,2.2172429044348454,0.30996051621092346,3.32892,5.409183333333334,6.437060511197818,4.369051666666667,4.882990255598909,Destabilizing,Destabilizing,Destabilizing,Destabilizing,1.3093914137576363,0.17477817165172127,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.5425,0.1018,-22.2244,-7.68498215740767,0.870327727664185,Pathogenic,0.9994,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282Q,NP_000537:p.Arg282Gln,"hg19,17:g.7577093C>T, hg19,17:g.7673775C>T, hg38,17:g.7673775C>T",,3.9770286823e-06,0.887,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",237956,Conflicting classifications of pathogenicity,1,,,,,1.79416,0.4885783803462982,1.3065733333333334,1.1731776419291025,1.5503666666666667,1.4836688209645512,Neutral,Neutral,Neutral,Neutral,Neutral,0.15587643103933022,0.4402752716451632,0.3171884043943882,0.46597,0.13979666666666665,0.7529112629522393,0.30288333333333334,0.6094406314761196,Neutral,Neutral,Neutral,Neutral,0.6365505249039981,0.4276725162592444,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.3751,0.1018,-22.2244,-6.94230616144628,0.5297725140910928,Uncertain,0.8664,pathogenic,-4.199,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282S,NP_000537:p.Arg282Ser,,,,,saturation_mutlist,,,,,,,,2.48655,0.9168435263633729,,1.9000618304445407,,2.19330591522227,,Uncertain,Neutral,,Uncertain,0.2551237881538625,,0.18299865689923003,0.45409,,1.2102044124770701,,0.8321472062385351,,Neutral,,Neutral,,0.16067367931789697,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.401,0.1018,-22.2244,-5.83254920892626,0.4661274651224045,Uncertain,0.9962,pathogenic,-4.071,available,https://doi.org/10.1101/2022.10.22.513328 +R282T,NP_000537:p.Arg282Thr,,,,,saturation_mutlist,,,,,,,,2.47009,0.9457354438304901,,1.4593372886819356,,1.9647136443409678,,Uncertain,Neutral,,Neutral,0.36490177157085324,,0.25857972946140473,0.16602,,0.9664519147130582,,0.5662359573565291,,Neutral,,Neutral,,0.15351297652936652,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.4053,0.1018,-22.2244,-6.48704533042472,0.8610729496384137,Pathogenic,0.9978,pathogenic,-4.517,available,https://doi.org/10.1101/2022.10.22.513328 +R282V,NP_000537:p.Arg282Val,,,,,saturation_mutlist,,,,,,,,2.05763,0.3855780041217804,,0.6201554854359073,,1.3388927427179538,,Uncertain,Neutral,,Neutral,0.4375192931210034,,0.3499508374288268,0.11066,,0.3414244182206849,,0.22604220911034245,,Neutral,,Neutral,,0.24758454141432587,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,uncertain,,-0.4169,0.1018,-22.2244,-6.32155105518406,0.8357707782166817,Pathogenic,0.9904,pathogenic,-4.496,available,https://doi.org/10.1101/2022.10.22.513328 +R282W,NP_000537:p.Arg282Trp,"hg19,17:g.7577094G>A, hg19,17:g.7577094_7577095delinsAA, hg19,17:g.7673776G>A, hg19,17:g.7673776_7673777delinsAA, hg38,17:g.7673776G>A, hg38,17:g.7673776_7673777delinsAA",,3.9775665248e-06,0.896,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12364,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,3.83596,-0.10563825845718383,1.8066899999999997,0.260681633903095,2.821325,2.0483208169515477,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,0.353306131181663,0.7625070979341766,0.26217344832945527,1.28235,1.72154,-0.530191749049164,1.501945,0.37607912547541805,Neutral,Neutral,Neutral,Neutral,2.2303882381474907,0.423019313490037,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,neutral,,-0.3503,0.1018,-8.9365,-6.64398279790623,0.7567491892719951,Pathogenic,0.9462,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282Y,NP_000537:p.Arg282Tyr,,,,,saturation_mutlist,,,,,,,,3.92202,-0.09995402336120605,,0.7867317899696674,,2.3543758949848335,,Uncertain,Neutral,,Uncertain,0.3452956388655374,,0.1998411311652698,0.00472,,-0.05702679294567687,,-0.026153396472838434,,Neutral,,Neutral,,0.1895631402240161,16.752,6.637,22.31,7.996,,True,16.752,,neutral,neutral,neutral,,True,22.31,,neutral,neutral,neutral,neutral,,-0.4219,0.1018,-22.2244,-7.0860137439162,0.8034458082034881,Pathogenic,0.987,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +R283A,NP_000537:p.Arg283Ala,,,,,saturation_mutlist,,,,,,,,0.52474,0.23575228214263916,,1.1388187653970385,,0.8317793826985193,,Neutral,Neutral,,Neutral,0.15591968964938452,,0.2174215634318478,-0.03052,,0.47632623930603896,,0.22290311965301948,,Neutral,,Neutral,,0.26336758152007866,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.3273,0.8968,-22.2273,-4.88528236491981,0.0261327887297848,Benign,0.9516,pathogenic,-3.588,available,https://doi.org/10.1101/2022.10.22.513328 +R283C,NP_000537:p.Arg283Cys,"hg19,17:g.7577091G>A, hg38,17:g.7673773G>A",9.55779278705e-05,7.15876551066e-05,0.740,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127824,Likely benign,3,,,,,0.98082,0.278048632144928,1.1125866666666668,1.733101654333039,1.0467033333333333,1.3569608271665197,Neutral,Neutral,Neutral,Neutral,Neutral,0.16652051652524744,0.1847099384320063,0.1754908925845064,0.59445,1.17007,1.2565599607212317,0.88226,0.9255049803606159,Neutral,Neutral,Neutral,Neutral,0.4480557581373104,0.26698357226009667,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.2603,0.8968,-7.3546,-3.11296296623348,0.0296076070566691,Benign,0.6812,pathogenic,-3.7,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R283D,NP_000537:p.Arg283Asp,,,,,saturation_mutlist,,,,,,,,1.7278,0.6237241506576539,,1.5543380825598332,,1.6410690412799167,,Neutral,Neutral,,Neutral,0.24379607143317208,,0.41617776174911475,0.2994,,0.6284623519706533,,0.4639311759853266,,Neutral,,Neutral,,0.5348925108451915,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.4183,0.8968,-22.2273,-5.24198780713334,0.0314398197972887,Benign,0.9866,pathogenic,-3.779,available,https://doi.org/10.1101/2022.10.22.513328 +R283E,NP_000537:p.Arg283Glu,,,,,saturation_mutlist,,,,,,,,0.94854,0.3905943822860718,,1.2839048860332956,,1.1162224430166479,,Neutral,Neutral,,Neutral,0.24468841562784102,,0.3156321308812982,-0.20192,,0.29061697280478077,,0.04434848640239039,,Neutral,,Neutral,,0.39069065621529914,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.2958,0.8968,-8.9394,-4.31891601029769,0.0194053819087281,Benign,0.9497,pathogenic,-3.496,available,https://doi.org/10.1101/2022.10.22.513328 +R283F,NP_000537:p.Arg283Phe,,,,,saturation_mutlist,,,,,,,,0.25935,0.39940049648284914,,0.3380762039022387,,0.29871310195111933,,Neutral,Neutral,,Neutral,0.18165446292776122,,0.25514572579249917,-0.22969,,0.1460144339334529,,-0.041837783033273554,,Neutral,,Neutral,,0.2263782061381713,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.3594,0.8968,-22.2273,-6.66771559775865,0.7134418883910211,Pathogenic,0.9745,pathogenic,-4.174,available,https://doi.org/10.1101/2022.10.22.513328 +R283G,NP_000537:p.Arg283Gly,"hg19,17:g.7577091G>C, hg38,17:g.7673773G>C",,,0.714,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",580186,Uncertain significance,2,,,,,1.28399,0.8164301085472107,1.6914966666666666,1.8356951191612818,1.4877433333333334,1.5598425595806409,Neutral,Neutral,Neutral,Neutral,Neutral,0.238463537407969,0.03660757875388958,0.29129351136550996,0.80751,1.2806133333333334,1.2331196752433093,1.0440616666666667,1.0203148376216546,Neutral,Neutral,Neutral,Neutral,0.288356911983897,0.30184011492442564,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.2948,0.8968,-8.9394,-6.02007111657914,0.5683618246267566,Uncertain,0.887,pathogenic,-3.938,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R283H,NP_000537:p.Arg283His,"hg19,17:g.7577090C>T, hg19,17:g.7673772C>T, hg38,17:g.7673772C>T",,3.9769021523e-05,0.836,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142324,Uncertain significance,2,,,,,0.87839,0.4541447377204895,0.9009066666666667,0.6989208584419027,0.8896483333333334,0.7886554292209513,Neutral,Neutral,Neutral,Neutral,Neutral,0.1892280326540583,0.14968257465568782,0.2802338919587909,0.54983,0.3869633333333333,0.189255104792919,0.4683966666666667,0.3695425523964595,Neutral,Neutral,Neutral,Neutral,0.18240671722524057,0.29454866785630385,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.2292,0.8968,-8.9394,-5.39678325222424,0.0406853243385057,Benign,0.549,ambiguous,-3.647,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R283I,NP_000537:p.Arg283Ile,,,,,saturation_mutlist,,,,,,,,0.74494,0.14380111694335937,,0.7792403206804911,,0.7620901603402456,,Neutral,Neutral,,Neutral,0.10114654006358686,,0.19247138803556077,-0.29951,,0.009552978036344065,,-0.14497851098182796,,Neutral,,Neutral,,0.17135202849509054,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.3567,0.8968,-22.2273,-6.03952946471489,0.5108935196120943,Uncertain,0.9034,pathogenic,-3.888,available,https://doi.org/10.1101/2022.10.22.513328 +R283K,NP_000537:p.Arg283Lys,,,,,saturation_mutlist,,,,,,,,0.12009,0.0405150270462036,,1.0009449787500133,,0.5605174893750067,,Neutral,Neutral,,Neutral,0.05356343607003031,,0.11084185056663821,-0.23036,,0.2861764462911272,,0.0279082231455636,,Neutral,,Neutral,,0.2089631637913361,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,uncertain,,-0.1061,0.8968,-0.3888,-1.81457329615729,1.575294263318473e-07,Benign,0.2513,benign,-2.835,available,https://doi.org/10.1101/2022.10.22.513328 +R283L,NP_000537:p.Arg283Leu,"hg19,17:g.7577090C>A, hg38,17:g.7673772C>A",,,0.685,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.01103,0.07193750381469725,-0.004763333333333332,0.1860777558664071,0.003133333333333334,0.09855387793320355,Neutral,Neutral,Neutral,Neutral,Neutral,0.08844917687335584,0.23165026085794843,0.25602668509101933,-0.44162,-0.06201666666666666,-0.20761271030453074,-0.2518183333333333,-0.3246163551522654,Neutral,Neutral,Neutral,Neutral,0.20150786524489697,0.207960808230911,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.3297,0.8968,-22.2273,-6.35027583660817,0.2315886254697959,Benign,0.8316,pathogenic,-3.685,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R283M,NP_000537:p.Arg283Met,,,,,saturation_mutlist,,,,,,,,-0.09976,0.1806696319580078,,0.6001177353293863,,0.25017886766469316,,Neutral,Neutral,,Neutral,0.08946135358324568,,0.1975167442664438,-0.56549,,0.18251148034352782,,-0.1914892598282361,,Neutral,,Neutral,,0.2530184117517303,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.2956,0.8968,-22.2273,-6.16826820355761,0.3185885570270371,Benign,0.9261,pathogenic,-3.765,available,https://doi.org/10.1101/2022.10.22.513328 +R283N,NP_000537:p.Arg283Asn,,,,,saturation_mutlist,,,,,,,,0.92674,0.4889629054069519,,1.141786139989322,,1.034263069994661,,Neutral,Neutral,,Neutral,0.19842167731438926,,0.28199426489813983,0.44968,,0.586076323589892,,0.5178781617949461,,Neutral,,Neutral,,0.33627908778647636,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.3422,0.8968,-22.2273,-4.9441430299059,0.0615201953029989,Benign,0.9767,pathogenic,-3.588,available,https://doi.org/10.1101/2022.10.22.513328 +R283P,NP_000537:p.Arg283Pro,"hg19,17:g.7577089_7577090delinsAG, hg19,17:g.7577090C>G, hg19,17:g.7673772C>G, hg38,17:g.7673772C>G",,,0.804,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",486555,Conflicting classifications of pathogenicity,1,,,,,1.8448,1.4356008505821227,5.55646,4.65574211906203,3.7006300000000003,3.250271059531015,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,0.35090071477604107,0.9602462028389731,0.8663640365975784,2.47358,7.7712,3.926561018066249,5.12239,3.2000705090331243,Uncertain,Uncertain,Destabilizing,Destabilizing,1.7299993833717586,1.9517242050567412,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.4694,0.8968,-22.2273,-7.14798341622502,0.7162607382875055,Pathogenic,0.9928,pathogenic,-4.052,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R283Q,NP_000537:p.Arg283Gln,,,,,saturation_mutlist,,,,,,,,0.48827,0.2013208484649658,,1.064129324148159,,0.7761996620740795,,Neutral,Neutral,,Neutral,0.15046010281300315,,0.224500281821397,-0.16012,,0.4550359132309664,,0.14745795661548322,,Neutral,,Neutral,,0.2449226808839654,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.302,0.8968,-22.2273,-5.06566589485979,0.0056528529605504,Benign,0.4967,ambiguous,-3.411,available,https://doi.org/10.1101/2022.10.22.513328 +R283S,NP_000537:p.Arg283Ser,"hg38,17:g.7673773G>T",,3.9770919504e-06,0.687,"COSMIC,saturation_mutlist",,,,,,,,0.6673,0.4786104774475098,1.11304,1.4667398065912478,0.89017,1.0670199032956238,Neutral,Neutral,Neutral,Neutral,Neutral,0.1757289280628722,0.04542811244152682,0.2388340399193514,0.3765,0.8026066666666666,0.7619090679039715,0.5895533333333333,0.5692045339519858,Neutral,Neutral,Neutral,Neutral,0.30493555617904283,0.43921800081126877,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.26,0.8968,-8.9394,-4.65990199428634,0.0353403553194113,Benign,0.9763,pathogenic,-3.494,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R283T,NP_000537:p.Arg283Thr,,,,,saturation_mutlist,,,,,,,,0.90137,0.5191166734695435,,1.3065350837588126,,1.1039525418794063,,Neutral,Neutral,,Neutral,0.15607644775630417,,0.203865425587667,0.23798,,0.5297282248038145,,0.38385411240190725,,Neutral,,Neutral,,0.2860323271953209,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.3322,0.8968,-22.2273,-4.90434831297447,0.0260475640366957,Benign,0.9458,pathogenic,-3.532,available,https://doi.org/10.1101/2022.10.22.513328 +R283V,NP_000537:p.Arg283Val,,,,,saturation_mutlist,,,,,,,,1.12378,0.38845221042633055,,0.9612559964895868,,1.0425179982447934,,Neutral,Neutral,,Neutral,0.13272366706421446,,0.06851552239891151,0.27289,,0.24606167999139839,,0.25947583999569923,,Neutral,,Neutral,,0.18422204082244348,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.3438,0.8968,-22.2273,-5.99490833784294,0.6056714299685131,Uncertain,0.9178,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328 +R283W,NP_000537:p.Arg283Trp,,,,,saturation_mutlist,,,,,,,,0.70542,0.39877007484436033,,-0.00738246490437409,,0.34901876754781297,,Neutral,Neutral,,Neutral,0.17892754914776393,,0.26511626368019114,-0.01904,,-0.35432777303987134,,-0.18668388651993567,,Neutral,,Neutral,,0.20735321571213758,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.345,0.8968,-22.2273,-6.66771559775865,0.7670761073656769,Pathogenic,0.8078,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328 +R283Y,NP_000537:p.Arg283Tyr,,,,,saturation_mutlist,,,,,,,,0.50301,0.4062247371673584,,0.44555319069119254,,0.4742815953455962,,Neutral,Neutral,,Neutral,0.20321500275248633,,0.27179041571056073,-0.27787,,0.21126630907964997,,-0.03330184546017502,,Neutral,,Neutral,,0.2185962893059453,52.647,10.991,71.29,13.069,,True,52.647,,neutral,neutral,neutral,,True,71.29,,neutral,neutral,neutral,neutral,,-0.3488,0.8968,-22.2273,-6.66771559775865,0.4249704105291157,Uncertain,0.928,pathogenic,-4.177,available,https://doi.org/10.1101/2022.10.22.513328 +T284A,NP_000537:p.Thr284Ala,"hg19,17:g.7577088T>C, hg38,17:g.7673770T>C",,,0.460,"COSMIC,ClinVar,saturation_mutlist",964952,Conflicting classifications of pathogenicity,1,,,,,-0.38966,-0.17559584379196166,0.24954333333333334,0.18455924522060588,-0.07005833333333333,-0.10255037738969706,Neutral,Neutral,Neutral,Neutral,Neutral,0.057918406599217286,0.28792157987124817,0.16178867078502115,-0.1253,-0.34920666666666667,0.037524960607214566,-0.23725333333333332,-0.043887519696392714,Neutral,Neutral,Neutral,Neutral,0.250697573759478,0.11107380589750643,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.0889,1.353,-0.8052,-2.3339254732691,0.0050191128834465,Benign,0.2587,benign,-3.194,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T284C,NP_000537:p.Thr284Cys,,,,,saturation_mutlist,,,,,,,,-0.05123,-0.19859339475631713,,0.8403069505094228,,0.3945384752547114,,Neutral,Neutral,,Neutral,0.055584536275047156,,0.04562734806633059,0.50952,,0.7290226575103201,,0.6192713287551601,,Neutral,,Neutral,,0.06851202088870506,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.2341,1.353,-22.2273,-3.94862837231201,0.7714462462401184,Pathogenic,0.7718,pathogenic,-3.927,available,https://doi.org/10.1101/2022.10.22.513328 +T284D,NP_000537:p.Thr284Asp,,,,,saturation_mutlist,,,,,,,,0.60861,-0.017636642456054674,,0.26459191639049323,,0.4366009581952466,,Neutral,Neutral,,Neutral,0.08257093627055934,,0.16922426228240228,0.51495,,0.20988569308498328,,0.36241784654249165,,Neutral,,Neutral,,0.08464629522633133,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,uncertain,,-0.3138,1.353,-22.2273,-4.34777641349292,0.6947168334646521,Pathogenic,0.9354,pathogenic,-3.933,available,https://doi.org/10.1101/2022.10.22.513328 +T284E,NP_000537:p.Thr284Glu,,,,,saturation_mutlist,,,,,,,,0.11506,-0.16940220355987548,,0.067889142792944,,0.091474571396472,,Neutral,Neutral,,Neutral,0.07048932887282623,,0.17419296860109668,0.05617,,-0.058122952214249866,,-0.0009764761071249344,,Neutral,,Neutral,,0.03508892316453029,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.2891,1.353,-22.2273,-5.05003937782916,0.6410322569464222,Uncertain,0.9007,pathogenic,-3.813,available,https://doi.org/10.1101/2022.10.22.513328 +T284F,NP_000537:p.Thr284Phe,,,,,saturation_mutlist,,,,,,,,-0.44261,0.010380702018737798,,-0.06770903162221897,,-0.2551595158111095,,Neutral,Neutral,,Neutral,0.0806874711395056,,0.06940416142535533,-0.28391,,-0.41976442895701815,,-0.3518372144785091,,Neutral,,Neutral,,0.032993945362189345,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.3055,1.353,-22.2273,-5.69551557163214,0.8339479394608507,Pathogenic,0.651,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328 +T284G,NP_000537:p.Thr284Gly,,,,,saturation_mutlist,,,,,,,,0.06888,0.37532205939292906,,0.8664520904363843,,0.4676660452181921,,Neutral,Neutral,,Neutral,0.07894186638866124,,0.16487525447340967,0.55457,,0.7505895444051992,,0.6525797722025997,,Neutral,,Neutral,,0.03203383855043597,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.2717,1.353,-22.2273,-4.75295064651016,0.3468646784972768,Uncertain,0.5084,ambiguous,-3.617,available,https://doi.org/10.1101/2022.10.22.513328 +T284H,NP_000537:p.Thr284His,,,,,saturation_mutlist,,,,,,,,0.06359,-0.002680349349975589,,-0.05036155356638794,,0.006614223216806027,,Neutral,Neutral,,Neutral,0.05450475791356455,,0.05042012645815126,0.40234,,-0.29047650229943583,,0.05593174885028207,,Neutral,,Neutral,,0.08803772402514713,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.2129,1.353,-7.9395,-3.62825289065798,0.0096209380811172,Benign,0.59,pathogenic,-3.477,available,https://doi.org/10.1101/2022.10.22.513328 +T284I,NP_000537:p.Thr284Ile,"hg19,17:g.7577087G>A, hg38,17:g.7673769G>A",,,0.699,"COSMIC,ClinVar,saturation_mutlist",216471,Likely benign,3,,,,,-0.43617,-0.2880414414405823,-0.20884333333333335,-0.17151198054071928,-0.32250666666666666,-0.30384099027035966,Neutral,Neutral,Neutral,Neutral,Neutral,0.09364947469266167,0.5914974235127506,0.13306404057044138,-0.32751,0.012356666666666674,-0.547271302097868,-0.15757666666666667,-0.43739065104893404,Neutral,Neutral,Neutral,Neutral,0.14578279604336797,0.14257412656955049,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.1461,1.353,-6.9395,-2.06270142512814,0.0061875841736767,Benign,0.5825,pathogenic,-3.343,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T284K,NP_000537:p.Thr284Lys,,,,,saturation_mutlist,,,,,,,,-0.45033,-0.2627458357810974,-0.21485333333333334,-0.05944434160585707,-0.3325916666666667,-0.25488717080292855,Neutral,Neutral,Neutral,Neutral,Neutral,0.06599936673633612,0.5307487352996917,0.14355829572426004,-0.19113,-0.38242666666666664,-0.16765546255201913,-0.2867783333333333,-0.17939273127600958,Neutral,Neutral,Neutral,Neutral,0.31598110390056905,0.05051935723866366,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.2813,1.353,-22.2273,-4.6111442380541,0.0663706688218792,Benign,0.7995,pathogenic,-3.598,available,https://doi.org/10.1101/2022.10.22.513328 +T284L,NP_000537:p.Thr284Leu,,,,,saturation_mutlist,,,,,,,,-0.67223,-0.30647945165634155,,-0.4262553769192741,,-0.5492426884596371,,Neutral,Neutral,,Neutral,0.061321114466621605,,0.14803990473600095,-0.43524,,-0.7336000412535881,,-0.5844200206267941,,Neutral,,Neutral,,0.25261328106657205,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.2083,1.353,-8.9394,-3.98154757536651,0.0846914174269106,Benign,0.2982,benign,-3.536,available,https://doi.org/10.1101/2022.10.22.513328 +T284M,NP_000537:p.Thr284Met,,,,,saturation_mutlist,,,,,,,,-0.66796,-0.1966314339637756,,-0.09165969127711728,,-0.37980984563855863,,Neutral,Neutral,,Neutral,0.0692791936062098,,0.08374478755718245,-0.60801,,-0.3214776282170726,,-0.4647438141085363,,Neutral,,Neutral,,0.20984083055152924,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.1752,1.353,-8.9394,-3.37821417242058,0.0089710863335161,Benign,0.1492,benign,-3.456,available,https://doi.org/10.1101/2022.10.22.513328 +T284N,NP_000537:p.Thr284Asn,,,,,saturation_mutlist,,,,,,,,0.04658,-0.08239867210388184,,0.2095716810371282,,0.1280758405185641,,Neutral,Neutral,,Neutral,0.0753170630726641,,0.08220426391030873,0.26954,,0.06172965247274859,,0.1656348262363743,,Neutral,,Neutral,,0.17143222378118111,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,uncertain,,-0.186,1.353,-8.9394,-3.24294529249877,0.0004106875649671,Benign,0.3113,benign,-3.383,available,https://doi.org/10.1101/2022.10.22.513328 +T284P,NP_000537:p.Thr284Pro,"hg19,17:g.7577088T>G, hg19,17:g.7673770T>G, hg38,17:g.7673770T>G",,,0.569,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1763670,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,1.82021,0.9933326363563537,8.35873,4.173208512582431,5.0894699999999995,2.996709256291216,Uncertain,Uncertain,Neutral,Destabilizing,Uncertain,0.19957531252775115,1.5107286242296019,1.237659815779161,2.42038,6.158730000000001,3.9317644304173225,4.289555000000001,3.176072215208661,Uncertain,Uncertain,Destabilizing,Destabilizing,2.682911071355143,1.2620500683691205,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,uncertain,potentially_damaging,uncertain,,-0.3625,1.353,-22.2273,-6.55732546763091,0.730739205711032,Pathogenic,0.912,pathogenic,-3.947,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T284Q,NP_000537:p.Thr284Gln,,,,,saturation_mutlist,,,,,,,,-0.37911,-0.17977028131484982,,0.21603672244626537,,-0.08153663877686732,,Neutral,Neutral,,Neutral,0.0445968542489316,,0.059550854634610045,-0.23891,,0.04259208807248301,,-0.0981589559637585,,Neutral,,Neutral,,0.15101166152212178,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.1955,1.353,-8.9394,-4.14074186450783,0.0401957249822921,Benign,0.5815,pathogenic,-3.386,available,https://doi.org/10.1101/2022.10.22.513328 +T284R,NP_000537:p.Thr284Arg,"hg19,17:g.7577087G>C, hg38,17:g.7673769G>C",,,0.728,"ClinVar,saturation_mutlist",2679230,Uncertain significance,1,,,,,-0.30038,-0.30365288972854615,,-0.2672912619145081,,-0.28383563095725406,,Neutral,Neutral,,Neutral,0.08949264955454188,,0.15268465998059408,-0.09734,,-0.4683111432705269,,-0.28282557163526345,,Neutral,,Neutral,,0.16316713833851756,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.2842,1.353,-22.2273,-2.54695884997668,0.2381645959285238,Benign,0.7429,pathogenic,-3.614,available,https://doi.org/10.1101/2022.10.22.513328 +T284S,NP_000537:p.Thr284Ser,"hg19,17:g.7577088T>A, hg38,17:g.7673770T>A",,,0.495,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458571,Conflicting classifications of pathogenicity,1,,,,,-0.28001,-0.016570827960967992,0.5452366666666667,0.41456347005152033,0.13261333333333336,0.06727673502576018,Neutral,Neutral,Neutral,Neutral,Neutral,0.05424748144790899,0.04148964556234349,0.12985970978961026,0.11701,0.01564333333333334,0.2831615154867306,0.06632666666666667,0.2000857577433653,Neutral,Neutral,Neutral,Neutral,0.24513214590411345,0.044717755114263014,68.043,14.262,70.475,11.596,P,True,68.043,1.595,neutral,neutral,potentially_damaging,P,True,70.475,0.77,neutral,neutral,potentially_damaging,neutral,,-0.0725,1.353,-4.6916,-1.78489914809022,1.6826522415187323e-05,Benign,0.2344,benign,-3.016,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T284V,NP_000537:p.Thr284Val,,,,,saturation_mutlist,,,,,,,,-0.02564,-0.1387923789024353,,-0.0009594157076775375,,-0.013299707853838768,,Neutral,Neutral,,Neutral,0.0591436169915149,,0.12253671344766474,0.19157,,-0.33658904259001404,,-0.07250952129500703,,Neutral,,Neutral,,0.1656148422043031,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.2117,1.353,-22.2273,-5.40818695111101,0.4978131721281743,Uncertain,0.4877,ambiguous,-3.625,available,https://doi.org/10.1101/2022.10.22.513328 +T284W,NP_000537:p.Thr284Trp,,,,,saturation_mutlist,,,,,,,,-0.08052,-0.00047851800918578493,,-0.4594418238992685,,-0.26998091194963425,,Neutral,Neutral,,Neutral,0.06054503454121549,,0.1603245957047541,0.11278,,-0.8379542917521569,,-0.36258714587607843,,Neutral,,Neutral,,0.08815008141653119,68.043,14.262,70.475,11.596,P,True,68.043,1.595,damaging,neutral,potentially_damaging,P,True,70.475,0.77,damaging,neutral,potentially_damaging,neutral,,-0.2984,1.353,-22.2273,-5.69551557163214,0.7889859019637193,Pathogenic,0.8708,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328 +T284Y,NP_000537:p.Thr284Tyr,,,,,saturation_mutlist,,,,,,,,-0.32382,0.009392201900482186,,0.001950060787436203,,-0.1609349696062819,,Neutral,Neutral,,Neutral,0.07023383505481329,,0.055456890810152176,-0.14365,,-0.3056263778112391,,-0.22463818890561954,,Neutral,,Neutral,,0.0178303783394443,68.043,14.262,70.475,11.596,P,True,68.043,1.595,uncertain,neutral,potentially_damaging,P,True,70.475,0.77,uncertain,neutral,potentially_damaging,neutral,,-0.2391,1.353,-8.9394,-5.37991928172987,0.5733601461266271,Uncertain,0.7255,pathogenic,-3.808,available,https://doi.org/10.1101/2022.10.22.513328 +E285A,NP_000537:p.Glu285Ala,"hg38,17:g.7673766T>G",,,0.910,"COSMIC,saturation_mutlist",,,,,,,,0.22258,0.8401336193084716,1.5627000000000002,0.7537223981351721,0.8926400000000001,0.48815119906758603,Neutral,Neutral,Neutral,Neutral,Neutral,0.21766498581302895,0.3293544841048926,0.3638072101403503,-0.62016,0.6,0.3951880301115837,-0.010080000000000033,-0.11248598494420817,Neutral,Neutral,Neutral,Neutral,0.24491243292246312,0.209518224061383,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,uncertain,,-0.227,1.0175,-22.2273,-6.95320772521685,0.6780560271371514,Uncertain,0.928,pathogenic,-3.902,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E285C,NP_000537:p.Glu285Cys,,,,,saturation_mutlist,,,,,,,,0.39531,0.6442564606666565,,1.441721197814318,,0.9185155989071591,,Neutral,Neutral,,Neutral,0.20352632056230832,,0.18812073555394582,-0.07909,,0.9278150715035469,,0.42436253575177346,,Neutral,,Neutral,,0.22770422241854754,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,uncertain,,-0.2963,1.0175,-22.2273,-7.02119446636457,0.8513810202459848,Pathogenic,0.996,pathogenic,-4.425,available,https://doi.org/10.1101/2022.10.22.513328 +E285D,NP_000537:p.Glu285Asp,"hg19,17:g.7577083C>A, hg19,17:g.7673765C>A",,,0.524,"cBioPortal,saturation_mutlist",,,,,,,,0.58084,0.680138909816742,1.1018166666666667,0.7719681511584886,0.8413283333333333,0.6764040755792443,Neutral,Neutral,Neutral,Neutral,Neutral,0.1620970850076008,0.1460032594004516,0.16574807752352178,0.56341,0.6001133333333334,0.7085502437120209,0.5817616666666667,0.6359801218560104,Neutral,Neutral,Neutral,Neutral,0.32637083757931284,0.03384556703626919,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,uncertain,,-0.0832,1.0175,-0.7797,-2.56733882937687,4.0873312263812165e-05,Benign,0.902,pathogenic,-3.008,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E285F,NP_000537:p.Glu285Phe,,,,,saturation_mutlist,,,,,,,,-0.17985,0.921955828666687,,0.2855012611915847,,0.052825630595792344,,Neutral,Neutral,,Neutral,0.3220331885482033,,0.197286264787104,-0.95442,,-0.24303479648938356,,-0.5987273982446918,,Neutral,,Neutral,,0.21164141694242433,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,neutral,,-0.274,1.0175,-22.2273,-7.26482183738778,0.8686135247093967,Pathogenic,0.9988,pathogenic,-4.415,available,https://doi.org/10.1101/2022.10.22.513328 +E285G,NP_000537:p.Glu285Gly,"hg19,17:g.7577084T>C, hg38,17:g.7673766T>C",,,0.923,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",919894,Uncertain significance,2,,,,,0.8375,1.4884567379951477,3.03617,1.9015173617440926,1.9368349999999999,1.3695086808720462,Uncertain,Neutral,Uncertain,Neutral,Neutral,0.23914260075495322,0.2155530024533795,0.30691426416295764,0.37179,2.1439866666666667,1.3125929051945218,1.2578883333333333,0.8421914525972609,Uncertain,Neutral,Neutral,Neutral,0.18859788551895867,0.10378035422420796,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,uncertain,,-0.2527,1.0175,-22.2273,-7.26482183738778,0.7124256363387507,Pathogenic,0.9509,pathogenic,-4.003,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E285H,NP_000537:p.Glu285His,,,,,saturation_mutlist,,,,,,,,0.40287,0.9696666240692139,,0.443101342269052,,0.422985671134526,,Neutral,Neutral,,Neutral,0.2588934193354847,,0.17571572681195818,0.07942,,0.07069735036364357,,0.07505867518182179,,Neutral,,Neutral,,0.08893516116164994,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,neutral,,-0.2652,1.0175,-22.2273,-7.26482183738778,0.8707481208299305,Pathogenic,0.9962,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328 +E285I,NP_000537:p.Glu285Ile,,,,,saturation_mutlist,,,,,,,,-0.10363,0.8098740959167481,,0.29224749915700216,,0.09430874957850108,,Neutral,Neutral,,Neutral,0.3092274862641984,,0.19862166334278886,-1.01308,,-0.2343620521195362,,-0.6237210260597681,,Neutral,,Neutral,,0.08199671882588666,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,neutral,,-0.2793,1.0175,-22.2273,-7.26482183738778,0.86715094464321,Pathogenic,0.9962,pathogenic,-4.402,available,https://doi.org/10.1101/2022.10.22.513328 +E285K,NP_000537:p.Glu285Lys,"hg19,17:g.7577083_7577085delinsTTT, hg19,17:g.7577085C>T, hg19,17:g.7673767C>T, hg38,17:g.7673765_7673767delinsTTT, hg38,17:g.7673767C>T",,,0.910,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",420133,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,-0.14229,1.5229746437072753,1.9735800000000001,0.8800825612595845,0.915645,0.36889628062979224,Neutral,Neutral,Uncertain,Neutral,Neutral,0.28076097769552816,0.08678855838569204,0.2815896479570893,-0.7353,1.7936500000000002,0.5610893113803955,0.5291750000000002,-0.08710534430980221,Neutral,Neutral,Neutral,Neutral,0.6880188254691872,0.07115870498916517,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,neutral,,-0.249,1.0175,-22.2273,-6.7541549855419,0.5802928899042646,Uncertain,0.9737,pathogenic,-4.14,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E285L,NP_000537:p.Glu285Leu,,,,,saturation_mutlist,,,,,,,,-0.76416,0.930895540714264,,0.1689308633263479,,-0.29761456833682604,,Neutral,Neutral,,Neutral,0.26336244036760176,,0.16083585522618504,-1.49435,,-0.4587895651764464,,-0.9765697825882232,,Neutral,,Neutral,,0.09052434532841076,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,neutral,,-0.2814,1.0175,-22.2273,-7.26482183738778,0.8195532070499358,Pathogenic,0.992,pathogenic,-3.984,available,https://doi.org/10.1101/2022.10.22.513328 +E285M,NP_000537:p.Glu285Met,,,,,saturation_mutlist,,,,,,,,-0.44751,0.8771683526039123,,0.45168519323759254,,0.0020875966187962613,,Neutral,Neutral,,Neutral,0.23094069900568745,,0.19236904868819796,-1.79066,,-0.08113432106867434,,-0.9358971605343371,,Neutral,,Neutral,,0.1324465546246238,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,neutral,,-0.2303,1.0175,-22.2273,-7.26482183738778,0.8165121365136547,Pathogenic,0.9895,pathogenic,-4.153,available,https://doi.org/10.1101/2022.10.22.513328 +E285N,NP_000537:p.Glu285Asn,,,,,saturation_mutlist,,,,,,,,0.3315,1.2657789421081542,,0.8603542716910573,,0.5959271358455287,,Neutral,Uncertain,,Neutral,0.20944201655995517,,0.2098542249823015,-0.45819,,0.472491221846346,,0.007150610923173012,,Neutral,,Neutral,,0.09859294042389952,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,uncertain,,-0.2532,1.0175,-22.2273,-3.69263011870532,0.7297544921489117,Pathogenic,0.9926,pathogenic,-3.979,available,https://doi.org/10.1101/2022.10.22.513328 +E285P,NP_000537:p.Glu285Pro,,,,,saturation_mutlist,,,,,,,,2.71334,1.5106488275527954,,4.615418310297258,,3.6643791551486293,,Uncertain,Uncertain,,Destabilizing,0.23530998042429851,,1.203748495601155,2.56136,,5.512799028687453,,4.037079514343726,,Uncertain,,Destabilizing,,0.6063782097773641,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,uncertain,,-0.3839,1.0175,-22.2273,-7.26482183738778,0.859088413966755,Pathogenic,0.9991,pathogenic,-4.382,available,https://doi.org/10.1101/2022.10.22.513328 +E285Q,NP_000537:p.Glu285Gln,"hg19,17:g.7577085C>G, hg19,17:g.7673767C>G, hg38,17:g.7673767C>G",,,0.883,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",954095,Uncertain significance,2,,,,,-0.10859,0.8136602210998535,1.3668933333333335,0.6326508511176606,0.6291516666666668,0.2620304255588303,Neutral,Neutral,Neutral,Neutral,Neutral,0.18655901354067295,0.17802640709238116,0.2653343971501725,-0.81719,0.4373,0.3704656493973282,-0.18994499999999997,-0.2233621753013359,Neutral,Neutral,Neutral,Neutral,0.14063933731356956,0.16131637578254543,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,neutral,,-0.1995,1.0175,-22.2273,-3.46091995644647,0.5247362620534087,Uncertain,0.9185,pathogenic,-3.732,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E285R,NP_000537:p.Glu285Arg,,,,,saturation_mutlist,,,,,,,,0.06898,1.557518219947815,,0.7133651642291122,,0.39117258211455613,,Neutral,Uncertain,,Neutral,0.2987259791018866,,0.2661177145598611,-0.74494,,0.09992105523951633,,-0.32250947238024186,,Neutral,,Neutral,,0.11603358797842697,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,neutral,,-0.2417,1.0175,-8.9394,-6.87868159016671,0.7510348299920128,Pathogenic,0.9783,pathogenic,-4.081,available,https://doi.org/10.1101/2022.10.22.513328 +E285S,NP_000537:p.Glu285Ser,,,,,saturation_mutlist,,,,,,,,0.43236,1.0847060513496398,,1.210556242512328,,0.821458121256164,,Neutral,Uncertain,,Neutral,0.19861939131124176,,0.24174149712008464,-0.05095,,0.8359391637581948,,0.39249458187909736,,Neutral,,Neutral,,0.08518543779512783,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,uncertain,,-0.2404,1.0175,-22.2273,-7.02119446636457,0.837841042464772,Pathogenic,0.975,pathogenic,-3.974,available,https://doi.org/10.1101/2022.10.22.513328 +E285T,NP_000537:p.Glu285Thr,,,,,saturation_mutlist,,,,,,,,0.26794,1.1067577123641967,,0.8475486104120624,,0.5577443052060312,,Neutral,Uncertain,,Neutral,0.2977493382548654,,0.15765949035656715,-0.04314,,0.5296461555366454,,0.2432530777683227,,Neutral,,Neutral,,0.11956064876259108,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,uncertain,,-0.2563,1.0175,-22.2273,-7.02119446636457,0.8699140235098215,Pathogenic,0.9862,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +E285V,NP_000537:p.Glu285Val,"hg19,17:g.7577084T>A, hg19,17:g.7673766T>A, hg38,17:g.7673766T>A",,0.0,0.936,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12384,Pathogenic,1,Oncogenic,1,,,0.12736,0.8887311434745788,1.0816333333333334,0.4456376165195848,0.6044966666666667,0.2864988082597924,Neutral,Neutral,Neutral,Neutral,Neutral,0.28870296073727125,0.2759983147694122,0.19073961692461355,-0.61809,-0.17415000000000003,-0.07627432931224232,-0.39612,-0.3471821646561212,Neutral,Neutral,Neutral,Neutral,0.23128286159304298,0.13616092671698876,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,uncertain,,-0.2402,1.0175,-22.2273,-7.26482183738778,0.8599815909545623,Pathogenic,0.9811,pathogenic,-4.218,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E285W,NP_000537:p.Glu285Trp,,,,,saturation_mutlist,,,,,,,,0.33608,0.7453018403053284,,-0.037110560750015335,,0.14948471962499232,,Neutral,Neutral,,Neutral,0.2924198784492257,,0.1607332322992557,-0.05574,,-0.6119737345272124,,-0.3338568672636062,,Neutral,,Neutral,,0.06965310836590251,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,neutral,,-0.2162,1.0175,-8.9394,-7.26482183738778,0.8696864149181326,Pathogenic,0.9991,pathogenic,-4.444,available,https://doi.org/10.1101/2022.10.22.513328 +E285Y,NP_000537:p.Glu285Tyr,,,,,saturation_mutlist,,,,,,,,-0.15229,0.6334677314758301,,0.42089215151235426,,0.1343010757561771,,Neutral,Neutral,,Neutral,0.3097769801860911,,0.21319257781798667,-0.54857,,-0.10413828749716393,,-0.32635414374858196,,Neutral,,Neutral,,0.2337071849443405,32.977,7.382,33.205,11.31,,True,32.977,,neutral,neutral,neutral,,True,33.205,,neutral,neutral,neutral,neutral,,-0.2748,1.0175,-22.2273,-7.26482183738778,0.8454117832036288,Pathogenic,0.9976,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328 +E286A,NP_000537:p.Glu286Ala,"hg19,17:g.7577081T>G, hg19,17:g.7673763T>G, hg38,17:g.7673763T>G",,,0.913,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376593,Likely pathogenic,1,,,,,1.72913,0.777157723903656,1.3015866666666667,0.6949743414048553,1.5153583333333334,1.2120521707024277,Neutral,Neutral,Neutral,Neutral,Neutral,0.2573135593834535,0.23163714099619018,0.18621471278327292,-0.33099,0.6704100000000001,0.45860657454270326,0.16971000000000003,0.06380828727135163,Neutral,Neutral,Neutral,Neutral,0.7898498252621613,0.2467018276608869,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,uncertain,,-0.3167,0.0424,-22.2273,-7.90930635631685,0.8126932455667674,Pathogenic,0.8823,pathogenic,-3.941,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E286C,NP_000537:p.Glu286Cys,,,,,saturation_mutlist,,,,,,,,2.01083,0.4990965270996094,,1.397509422033948,,1.704169711016974,,Uncertain,Neutral,,Neutral,0.2389308133647375,,0.1381832125035849,0.35734,,1.154762865077422,,0.756051432538711,,Neutral,,Neutral,,0.19383242987198523,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,uncertain,,-0.3861,0.0424,-22.2273,-7.90930635631685,0.8698395592205053,Pathogenic,0.9947,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +E286D,NP_000537:p.Glu286Asp,"hg19,17:g.7577080T>G, hg38,17:g.7673762T>A, hg38,17:g.7673762T>G",,,0.765,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3893866,Uncertain significance,1,,,,,1.63196,0.14065537691116334,1.0312933333333334,1.2799780569088821,1.3316266666666667,1.455969028454441,Neutral,Neutral,Neutral,Neutral,Neutral,0.2888117970926602,0.5555221939960835,0.042728611455368055,0.5871,1.2518133333333334,0.6281314901775054,0.9194566666666667,0.6076157450887527,Neutral,Neutral,Neutral,Neutral,0.483424758870384,0.29178744478352575,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,uncertain,,-0.2146,0.0424,-8.9394,-3.90618216975713,0.1905307891879662,Benign,0.9266,pathogenic,-3.579,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E286F,NP_000537:p.Glu286Phe,,,,,saturation_mutlist,,,,,,,,1.25168,1.0088707065582276,,0.07836236523563783,,0.6650211826178188,,Neutral,Uncertain,,Neutral,0.27955910065137335,,0.37726967695597696,-0.21413,,-0.01641391339704883,,-0.11527195669852441,,Neutral,,Neutral,,0.16289328711466358,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,neutral,,-0.3637,0.0424,-22.2273,-7.90930635631685,0.8234987158424463,Pathogenic,0.9985,pathogenic,-4.508,available,https://doi.org/10.1101/2022.10.22.513328 +E286G,NP_000537:p.Glu286Gly,"hg19,17:g.7577081T>C, hg19,17:g.7673763T>C, hg38,17:g.7673763T>C",,,0.913,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376590,Conflicting classifications of pathogenicity,1,,,,,2.5913,1.3318292284011841,2.7927433333333336,2.2570659338013113,2.6920216666666668,2.4241829669006556,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,0.2665376047523817,0.2669948375697346,0.10645619203804293,0.56142,2.0107733333333333,1.2034928911511158,1.2860966666666667,0.8824564455755579,Uncertain,Neutral,Neutral,Neutral,0.7379220485179236,0.4283688357757543,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,uncertain,,-0.3424,0.0424,-22.2273,-7.90930635631685,0.8140714270677522,Pathogenic,0.8932,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E286H,NP_000537:p.Glu286His,,,,,saturation_mutlist,,,,,,,,2.23579,0.8999330067634582,,0.5840008183879004,,1.4098954091939504,,Uncertain,Neutral,,Neutral,0.2496512833820832,,0.20692956838817952,0.39536,,0.14209099382190024,,0.2687254969109501,,Neutral,,Neutral,,0.20221189444436813,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,neutral,,-0.355,0.0424,-22.2273,-7.90930635631685,0.870458070176432,Pathogenic,0.9955,pathogenic,-4.235,available,https://doi.org/10.1101/2022.10.22.513328 +E286I,NP_000537:p.Glu286Ile,,,,,saturation_mutlist,,,,,,,,1.83097,0.5990828108787537,,-0.08933584211130474,,0.8708170789443477,,Neutral,Neutral,,Neutral,0.38475282706886316,,0.03884382067772009,-0.00583,,-0.040517859260435135,,-0.02317392963021757,,Neutral,,Neutral,,0.16209358401074664,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,neutral,,-0.369,0.0424,-22.2273,-6.4916484275469,0.6201150502836061,Uncertain,0.9713,pathogenic,-4.136,available,https://doi.org/10.1101/2022.10.22.513328 +E286K,NP_000537:p.Glu286Lys,"hg19,17:g.7577082C>T, hg19,17:g.7577082_7577083delinsTT, hg19,17:g.7673764C>T, hg19,17:g.7673764_7673765delinsTT, hg38,17:g.7673764C>T, hg38,17:g.7673764_7673765delinsTT",,,0.949,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",183752,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,1.48244,1.5394156742095948,1.8283466666666666,1.3093996754687787,1.6553933333333333,1.3959198377343893,Neutral,Neutral,Uncertain,Neutral,Neutral,0.28373508763699967,0.3428378835867213,0.17420267131418968,-0.23528,1.1839,0.5402254456971012,0.47431,0.1524727228485506,Neutral,Neutral,Neutral,Neutral,0.6389098154408543,0.4264677387513556,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,neutral,,-0.2709,0.0424,-8.9394,-6.24017220790887,0.7011857895247449,Pathogenic,0.9477,pathogenic,-3.982,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E286L,NP_000537:p.Glu286Leu,,,,,saturation_mutlist,,,,,,,,0.62004,0.7941438508033752,,-0.387008482725751,,0.11651575863712452,,Neutral,Neutral,,Neutral,0.30142470699764723,,0.1886477913831815,-0.68122,,-0.4126149331045903,,-0.5469174665522951,,Neutral,,Neutral,,0.13804602928287335,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,neutral,,-0.3712,0.0424,-22.2273,-7.16464546047637,0.8706711220409482,Pathogenic,0.9735,pathogenic,-4.168,available,https://doi.org/10.1101/2022.10.22.513328 +E286M,NP_000537:p.Glu286Met,,,,,saturation_mutlist,,,,,,,,0.9684,0.7947653722763062,,0.08341679243733009,,0.525908396218665,,Neutral,Neutral,,Neutral,0.19823132030358376,,0.20973682594738322,-0.84612,,-0.007871230525335863,,-0.42699561526266794,,Neutral,,Neutral,,0.1856533294821243,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,neutral,,-0.32,0.0424,-22.2273,-7.16464546047637,0.8705651021235515,Pathogenic,0.9622,pathogenic,-4.282,available,https://doi.org/10.1101/2022.10.22.513328 +E286N,NP_000537:p.Glu286Asn,,,,,saturation_mutlist,,,,,,,,1.95407,0.9296180629730224,,1.144819856939719,,1.5494449284698595,,Neutral,Neutral,,Neutral,0.2895578075987242,,0.14378172404783265,0.20682,,0.5161200928659214,,0.3614700464329607,,Neutral,,Neutral,,0.2781066679075226,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,uncertain,,-0.3429,0.0424,-22.2273,-4.15346829351254,0.6955914676434517,Pathogenic,0.9783,pathogenic,-4.034,available,https://doi.org/10.1101/2022.10.22.513328 +E286P,NP_000537:p.Glu286Pro,,,,,saturation_mutlist,,,,,,,,6.31112,1.133770589828491,,7.135513380625608,,6.723316690312804,,Destabilizing,Uncertain,,Destabilizing,0.2685136152033032,,0.2970555712548468,5.05802,,6.073040051347399,,5.5655300256736995,,Destabilizing,,Destabilizing,,1.17986179483147,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,uncertain,,-0.4737,0.0424,-22.2273,-7.90930635631685,0.8597076942664754,Pathogenic,0.9987,pathogenic,-4.502,available,https://doi.org/10.1101/2022.10.22.513328 +E286Q,NP_000537:p.Glu286Gln,"hg19,17:g.7577082C>G, hg19,17:g.7673764C>G, hg38,17:g.7673764C>G",,,0.905,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376591,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,0.69578,0.6582112836837769,0.29036333333333336,0.7220298568593471,0.4930716666666667,0.7089049284296736,Neutral,Neutral,Neutral,Neutral,Neutral,0.13290016506213792,0.5803326699019757,0.09855848507354559,-0.31477,0.48525999999999997,0.38311464586204313,0.08524499999999999,0.03417232293102157,Neutral,Neutral,Neutral,Neutral,0.34826976450255726,0.2110421829245882,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,neutral,,-0.2892,0.0424,-22.2273,-4.74818094996343,0.8247652464799524,Pathogenic,0.8972,pathogenic,-3.936,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E286R,NP_000537:p.Glu286Arg,,,,,saturation_mutlist,,,,,,,,1.90593,1.5840004587173462,,0.757660155671838,,1.3317950778359189,,Neutral,Uncertain,,Neutral,0.30330003084875395,,0.144720983706636,-0.10316,,0.1987825262803912,,0.0478112631401956,,Neutral,,Neutral,,0.37268099659070325,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,neutral,,-0.3992,0.0424,-22.2273,-7.64405279326017,0.8682067716917614,Pathogenic,0.971,pathogenic,-4.309,available,https://doi.org/10.1101/2022.10.22.513328 +E286S,NP_000537:p.Glu286Ser,,,,,saturation_mutlist,,,,,,,,2.57855,0.7288546872138977,,1.4537700414365666,,2.0161600207182833,,Uncertain,Neutral,,Uncertain,0.2731566538452463,,0.10764244991605457,0.02665,,0.923976014301301,,0.4753130071506505,,Neutral,,Neutral,,0.2969942903291169,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,uncertain,,-0.3301,0.0424,-22.2273,-7.90930635631685,0.8649307561841211,Pathogenic,0.972,pathogenic,-4.159,available,https://doi.org/10.1101/2022.10.22.513328 +E286T,NP_000537:p.Glu286Thr,,,,,saturation_mutlist,,,,,,,,1.93888,0.684873161315918,,0.9344345169545325,,1.436657258477266,,Neutral,Neutral,,Neutral,0.2668663820785277,,0.16048167163249905,0.18338,,0.5787938118199709,,0.38108690590998545,,Neutral,,Neutral,,0.24767342216334604,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,uncertain,,-0.346,0.0424,-22.2273,-7.90930635631685,0.8092552299023816,Pathogenic,0.9508,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328 +E286V,NP_000537:p.Glu286Val,"hg19,17:g.7577081T>A, hg19,17:g.7673763T>A, hg38,17:g.7673763T>A",,,0.916,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376592,Conflicting classifications of pathogenicity,1,,,,,1.13305,0.5593272137641907,0.33560000000000006,0.11268861953088587,0.734325,0.6228693097654429,Neutral,Neutral,Neutral,Neutral,Neutral,0.4896570386672767,0.32938540839974484,0.13497246971905497,0.41808,0.06280999999999996,0.19182717160578874,0.240445,0.3049535858028944,Neutral,Neutral,Neutral,Neutral,0.7287301159322748,0.21448187370226496,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,uncertain,,-0.3299,0.0424,-22.2273,-7.16464546047637,0.8395726865198525,Pathogenic,0.9153,pathogenic,-4.136,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E286W,NP_000537:p.Glu286Trp,,,,,saturation_mutlist,,,,,,,,1.58113,0.7982168054580688,,-0.41154204652936216,,0.5847939767353189,,Neutral,Neutral,,Neutral,0.2856517603402777,,0.19873150444926618,-0.29083,,-0.4332559691003519,,-0.3620429845501759,,Neutral,,Neutral,,0.2201698403853103,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,neutral,,-0.3738,0.0424,-22.2273,-7.90930635631685,0.8656451988486518,Pathogenic,0.999,pathogenic,-4.624,available,https://doi.org/10.1101/2022.10.22.513328 +E286Y,NP_000537:p.Glu286Tyr,,,,,saturation_mutlist,,,,,,,,1.63,0.9519830977916718,,0.3256747121359781,,0.9778373560679889,,Neutral,Neutral,,Neutral,0.24354178444040148,,0.3346299312605478,-0.11034,,0.1176653600712496,,0.003662680035624803,,Neutral,,Neutral,,0.2230159824889406,28.509,7.008,56.04,14.224,,True,28.509,,neutral,neutral,neutral,,True,56.04,,neutral,neutral,neutral,neutral,,-0.3645,0.0424,-22.2273,-7.90930635631685,0.8702551529493752,Pathogenic,0.9951,pathogenic,-4.462,available,https://doi.org/10.1101/2022.10.22.513328 +E287A,NP_000537:p.Glu287Ala,"hg38,17:g.7673760T>G",,,0.562,"COSMIC,saturation_mutlist",,,,,,,,0.23068,0.13934487819671632,0.89161,0.3657347169839664,0.561145,0.2982073584919832,Neutral,Neutral,Neutral,Neutral,Neutral,0.1985638673802342,0.23287937406877976,0.059719214306458136,-0.31503,0.11598666666666664,0.08184824480064576,-0.09952166666666667,-0.11659087759967711,Neutral,Neutral,Neutral,Neutral,0.3258925558455663,0.05260445089267372,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,uncertain,,-0.0959,1.5384,-5.9307,-2.68319937612633,0.0003168862573925,Benign,0.1824,benign,-3.33,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E287C,NP_000537:p.Glu287Cys,,,,,saturation_mutlist,,,,,,,,0.31429,-0.09993120193481446,,0.86997317210553,,0.5921315860527651,,Neutral,Neutral,,Neutral,0.13570165785938973,,0.027871241721432113,0.1561,,0.7413897236503025,,0.4487448618251513,,Neutral,,Neutral,,0.0705038076132398,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,uncertain,,-0.1725,1.5384,-7.3457,-2.84916746173766,0.030367191050473,Benign,0.8447,pathogenic,-3.856,available,https://doi.org/10.1101/2022.10.22.513328 +E287D,NP_000537:p.Glu287Asp,"hg19,17:g.7577077C>A, hg19,17:g.7577077C>G, hg19,17:g.7673759C>A, hg19,17:g.7673759C>G, hg38,17:g.7673759C>A, hg38,17:g.7673759C>G",,7.9527922254e-06,0.405,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","925213, 422130","Uncertain significance, Conflicting classifications of pathogenicity","2, 1",Uncertain significance,1,,,0.33348,0.0007977128028869701,0.3523833333333333,0.2941808788092061,0.34293166666666663,0.3138304394046031,Neutral,Neutral,Neutral,Neutral,Neutral,0.057196213942286446,0.11620207867714281,0.06643264951779612,0.63271,0.59206,0.07379647714108244,0.612385,0.3532532385705412,Neutral,Neutral,Neutral,Neutral,0.2000968687078003,0.14783153956709288,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,uncertain,,-0.0349,1.5384,-0.7019,-0.540707185298792,7.0503704975414175e-09,Benign,0.0988,benign,-2.902,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E287F,NP_000537:p.Glu287Phe,,,,,saturation_mutlist,,,,,,,,-0.84197,0.08835373163223266,,-0.11332900246968959,,-0.4776495012348448,,Neutral,Neutral,,Neutral,0.13639171898080166,,0.10422493341539407,-0.58951,,-0.24465724086593219,,-0.4170836204329661,,Neutral,,Neutral,,0.07032394346905738,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,neutral,,-0.226,1.5384,-22.2185,-3.90067976443282,0.0878927624445562,Benign,0.8277,pathogenic,-3.972,available,https://doi.org/10.1101/2022.10.22.513328 +E287G,NP_000537:p.Glu287Gly,"hg38,17:g.7673760T>C",,,0.626,"COSMIC,saturation_mutlist",,,,,,,,0.35914,0.37460694432258607,1.7204066666666666,1.0652456008737279,1.0397733333333332,0.712192800436864,Neutral,Neutral,Neutral,Neutral,Neutral,0.20576399882751412,0.1776724954015737,0.15771236144398676,-0.08,1.0884333333333334,0.6865092053402878,0.5042166666666666,0.3032546026701439,Neutral,Neutral,Neutral,Neutral,0.3162575677443238,0.11739785361329734,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,uncertain,,-0.1267,1.5384,-6.9307,-3.2298702077559,0.0035545860353111,Benign,0.1655,benign,-3.454,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E287H,NP_000537:p.Glu287His,,,,,saturation_mutlist,,,,,,,,0.04477,0.10601535797119141,,-0.022925055198422233,,0.010922472400788882,,Neutral,Neutral,,Neutral,0.13420302689247485,,0.022500775077258,-0.13383,,-0.26011432290343933,,-0.19697216145171967,,Neutral,,Neutral,,0.11909579040299365,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,neutral,,-0.2173,1.5384,-22.2185,-5.51492422806166,0.4623994728204355,Uncertain,0.6192,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328 +E287I,NP_000537:p.Glu287Ile,,,,,saturation_mutlist,,,,,,,,-0.12664,0.026000885963439933,,-0.04781326941534177,,-0.08722663470767089,,Neutral,Neutral,,Neutral,0.210558002921807,,0.17231901404592265,-0.3944,,-0.20409534306598953,,-0.29924767153299475,,Neutral,,Neutral,,0.09481899182742143,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,neutral,,-0.1584,1.5384,-7.9307,-2.97579347758502,0.0127123005449336,Benign,0.4845,ambiguous,-3.718,available,https://doi.org/10.1101/2022.10.22.513328 +E287K,NP_000537:p.Glu287Lys,"hg19,17:g.7577079C>T, hg19,17:g.7673761C>T, hg38,17:g.7673761C>T",,3.9765226105e-06,0.583,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141781,Conflicting classifications of pathogenicity,1,,,,,-0.63824,0.21962971687316896,0.6952366666666666,0.19242427964682554,0.028498333333333292,-0.22290786017658726,Neutral,Neutral,Neutral,Neutral,Neutral,0.20101996786757198,0.17362082177997992,0.06899723850666914,-0.53683,0.12879666666666667,-0.016068771343792403,-0.20401666666666668,-0.2764493856718962,Neutral,Neutral,Neutral,Neutral,0.3306404649901293,0.12886918026639588,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,neutral,,-0.1281,1.5384,-7.9307,-1.38336550309718,0.0019031646392758,Benign,0.2975,benign,-3.661,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E287L,NP_000537:p.Glu287Leu,,,,,saturation_mutlist,,,,,,,,-0.84829,-0.011212387084960938,,-0.3293916404758196,,-0.5888408202379098,,Neutral,Neutral,,Neutral,0.13878535019721863,,0.10304605325067522,-0.63563,,-0.5605369596665196,,-0.5980834798332598,,Neutral,,Neutral,,0.10805805579138804,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,neutral,,-0.1657,1.5384,-8.9306,-3.34721155456983,0.0108025597542791,Benign,0.4856,ambiguous,-3.721,available,https://doi.org/10.1101/2022.10.22.513328 +E287M,NP_000537:p.Glu287Met,,,,,saturation_mutlist,,,,,,,,-0.68473,0.11556291580200195,,-0.004056340881551536,,-0.3443931704407757,,Neutral,Neutral,,Neutral,0.14382822432334108,,0.1172928150396469,-0.76513,,-0.21513356597021893,,-0.49013178298510945,,Neutral,,Neutral,,0.0848652265806043,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,neutral,,-0.1823,1.5384,-22.2185,-4.58454873948403,0.2404380469519403,Benign,0.5104,ambiguous,-3.847,available,https://doi.org/10.1101/2022.10.22.513328 +E287N,NP_000537:p.Glu287Asn,,,,,saturation_mutlist,,,,,,,,0.08848,0.12102107524871826,,0.22344847967288375,,0.15596423983644186,,Neutral,Neutral,,Neutral,0.11532820739096222,,0.05900525247114496,0.00624,,0.04168389010674844,,0.02396194505337422,,Neutral,,Neutral,,0.13421646613065594,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,uncertain,,-0.1323,1.5384,-7.9307,-1.71141821259126,0.0103066570062662,Benign,0.2722,benign,-3.534,available,https://doi.org/10.1101/2022.10.22.513328 +E287P,NP_000537:p.Glu287Pro,,,,,saturation_mutlist,,,,,,,,1.36417,0.3616913974285126,,4.243217595699385,,2.803693797849693,,Uncertain,Neutral,,Uncertain,0.4024133230166925,,0.2199306974067126,3.0736,,5.10925770454931,,4.091428852274655,,Destabilizing,,Destabilizing,,0.5228985231583714,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,uncertain,,-0.336,1.5384,-22.2185,-5.98346379312948,0.4699580654786057,Uncertain,0.9618,pathogenic,-4.224,available,https://doi.org/10.1101/2022.10.22.513328 +E287Q,NP_000537:p.Glu287Gln,"hg19,17:g.7577079C>G, hg19,17:g.7673761C>G, hg38,17:g.7673761C>G",,,0.623,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,-0.29514,0.1229530668258667,0.007596666666666678,0.17063665496529987,-0.14377166666666666,-0.06225167251735007,Neutral,Neutral,Neutral,Neutral,Neutral,0.1355007847054382,0.3283257554455466,0.056568693140990826,-0.41103,0.08344666666666667,0.06081470536537347,-0.16379166666666667,-0.17510764731731326,Neutral,Neutral,Neutral,Neutral,0.24860761135215112,0.0882111774291124,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,neutral,,-0.0718,1.5384,-6.6088,-1.86040094675046,0.0045154223733136,Benign,0.2004,benign,-3.418,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E287R,NP_000537:p.Glu287Arg,,,,,saturation_mutlist,,,,,,,,-0.70237,0.26795789003372195,,0.015587914248495498,,-0.3433910428757523,,Neutral,Neutral,,Neutral,0.20505974958144077,,0.04765339445499531,-0.66498,,-0.24921609185067137,,-0.4570980459253357,,Neutral,,Neutral,,0.09201507116225455,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,neutral,,-0.1937,1.5384,-8.9306,-3.35333267750453,0.0026107397299404,Benign,0.4529,ambiguous,-3.744,available,https://doi.org/10.1101/2022.10.22.513328 +E287S,NP_000537:p.Glu287Ser,,,,,saturation_mutlist,,,,,,,,0.40836,0.1841559910774231,,0.6103990398044572,,0.5093795199022286,,Neutral,Neutral,,Neutral,0.176764448395071,,0.06310948016005567,-0.06217,,0.3304285288097443,,0.13412926440487216,,Neutral,,Neutral,,0.11291347611832081,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,uncertain,,-0.1047,1.5384,-5.0238,-2.47189389597539,8.32042712956667e-05,Benign,0.277,benign,-3.334,available,https://doi.org/10.1101/2022.10.22.513328 +E287T,NP_000537:p.Glu287Thr,,,,,saturation_mutlist,,,,,,,,0.67577,0.1638018536567688,,0.3752762407551253,,0.5255231203775627,,Neutral,Neutral,,Neutral,0.13437204718506576,,0.07234887776452673,0.0368,,0.12152148997573864,,0.07916074498786932,,Neutral,,Neutral,,0.09142511012794936,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,uncertain,,-0.1354,1.5384,-7.9307,-2.76941398254902,0.017014020593624,Benign,0.3237,benign,-3.554,available,https://doi.org/10.1101/2022.10.22.513328 +E287V,NP_000537:p.Glu287Val,"hg38,17:g.7673760T>A",,,0.644,"COSMIC,saturation_mutlist",,,,,,,,0.33046,0.08226005315780639,1.4831066666666668,0.04976635877704864,0.9067833333333334,0.19011317938852432,Neutral,Neutral,Neutral,Neutral,Neutral,0.20351166383851363,0.6222350308542764,0.14377314171618305,0.09707,0.18174666666666664,-0.05534804873226643,0.13940833333333333,0.020860975633866786,Neutral,Neutral,Neutral,Neutral,0.3040125081125592,0.10812404744930545,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,uncertain,,-0.1922,1.5384,-22.2185,-4.95686971720322,0.1484730324608424,Benign,0.3116,benign,-3.922,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E287W,NP_000537:p.Glu287Trp,,,,,saturation_mutlist,,,,,,,,-0.35695,0.07763081789016722,,-0.3980104502531125,,-0.3774802251265562,,Neutral,Neutral,,Neutral,0.13440245617936988,,0.12962576296645953,-0.41866,,-0.5821437291130268,,-0.5004018645565134,,Neutral,,Neutral,,0.04553921308454532,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,neutral,,-0.2361,1.5384,-22.2185,-5.51492422806166,0.6901302658969299,Pathogenic,0.9127,pathogenic,-4.302,available,https://doi.org/10.1101/2022.10.22.513328 +E287Y,NP_000537:p.Glu287Tyr,,,,,saturation_mutlist,,,,,,,,-0.7587,0.0932569909095764,,-0.0029907082506733704,,-0.3808453541253367,,Neutral,Neutral,,Neutral,0.14711241588559137,,0.11321378463591211,-0.39211,,-0.13108171946895153,,-0.26159585973447574,,Neutral,,Neutral,,0.05031775150282002,58.413,12.743,86.59,6.943,,True,58.413,,neutral,neutral,neutral,,True,86.59,,neutral,neutral,neutral,neutral,,-0.2268,1.5384,-22.2185,-5.51492422806166,0.4490908828313668,Uncertain,0.6695,pathogenic,-4.074,available,https://doi.org/10.1101/2022.10.22.513328 +N288A,NP_000537:p.Asn288Ala,,,,,saturation_mutlist,,,,,,,,0.58071,0.14394104242324826,,0.677826493539833,,0.6292682467699164,,Neutral,Neutral,,Neutral,0.1357727384149009,,0.11092972006571894,0.19897,,0.9157058876849901,,0.557337943842495,,Neutral,,Neutral,,0.2267490566073052,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,uncertain,,-0.1154,1.5821,-8.9247,-1.97776969900807,0.0560701684058706,Benign,0.5559,ambiguous,-3.265,available,https://doi.org/10.1101/2022.10.22.513328 +N288C,NP_000537:p.Asn288Cys,,,,,saturation_mutlist,,,,,,,,0.45591,-0.04380758047103882,,1.0638142866218583,,0.7598621433109292,,Neutral,Neutral,,Neutral,0.085096579697907,,0.16046996172936917,0.26672,,1.2824044199777986,,0.7745622099888994,,Neutral,,Neutral,,0.3356099782634021,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,uncertain,,-0.2331,1.5821,-22.2125,-3.0392913194599,0.8229463801093728,Pathogenic,0.6331,pathogenic,-3.706,available,https://doi.org/10.1101/2022.10.22.513328 +N288D,NP_000537:p.Asn288Asp,"hg19,17:g.7577076T>C, hg38,17:g.7673758T>C",,,0.513,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1024822,Uncertain significance,1,,,,,0.69484,0.1167343521118164,0.49058666666666667,0.15732939021759354,0.5927133333333333,0.42608469510879676,Neutral,Neutral,Neutral,Neutral,Neutral,0.17811581846793773,0.027514187047573996,0.20209202215060001,0.81881,0.5187066666666666,0.44839339627516533,0.6687583333333333,0.6336016981375827,Neutral,Neutral,Neutral,Neutral,0.17845865185589133,0.14732156101061172,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,uncertain,,-0.1864,1.5821,-22.2125,-3.55350596031586,0.4389726511698135,Uncertain,0.7619,pathogenic,-3.63,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N288E,NP_000537:p.Asn288Glu,,,,,saturation_mutlist,,,,,,,,0.67231,0.1815762686729431,,0.37685690078226086,,0.5245834503911304,,Neutral,Neutral,,Neutral,0.14183610519257045,,0.20140064028006527,0.63382,,0.7334065990731667,,0.6836132995365833,,Neutral,,Neutral,,0.23445312808546553,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,neutral,,-0.2135,1.5821,-22.2125,-3.09649044635862,0.2518849935410834,Benign,0.8884,pathogenic,-3.542,available,https://doi.org/10.1101/2022.10.22.513328 +N288F,NP_000537:p.Asn288Phe,,,,,saturation_mutlist,,,,,,,,0.11502,0.22231716871261598,,0.4378082606302485,,0.27641413031512424,,Neutral,Neutral,,Neutral,0.1350842103218462,,0.24242255971214852,-0.30488,,0.4640063468090639,,0.07956317340453195,,Neutral,,Neutral,,0.39033164411915267,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,neutral,,-0.2403,1.5821,-22.2125,-3.87100364189457,0.8039172021829037,Pathogenic,0.825,pathogenic,-3.887,available,https://doi.org/10.1101/2022.10.22.513328 +N288G,NP_000537:p.Asn288Gly,,,,,saturation_mutlist,,,,,,,,-0.21062,0.1402039957046509,,0.4518257652911097,,0.12060288264555484,,Neutral,Neutral,,Neutral,0.17322534138915646,,0.03672570134952097,-0.4281,,0.8460138950117351,,0.20895694750586755,,Neutral,,Neutral,,0.21197844716153874,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,uncertain,,-0.1462,1.5821,-8.9247,-3.60102186334272,0.3833029398647519,Uncertain,0.5693,pathogenic,-3.531,available,https://doi.org/10.1101/2022.10.22.513328 +N288H,NP_000537:p.Asn288His,"hg38,17:g.7673758T>G",,,0.554,"COSMIC,saturation_mutlist",,,,,,,,0.24355,0.14128840446472166,0.14728,0.0592896118571886,0.195415,0.1514198059285943,Neutral,Neutral,Neutral,Neutral,Neutral,0.07485221255694355,0.21217110029407868,0.15799247920429504,-0.37929,0.05725666666666666,0.2698283862696467,-0.16101666666666667,-0.054730806865176646,Neutral,Neutral,Neutral,Neutral,0.3845851791505001,0.2630343335321578,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,neutral,,-0.0887,1.5821,-2.7154,-2.24138614304595,0.0307187013914106,Benign,0.3465,ambiguous,-3.337,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N288I,NP_000537:p.Asn288Ile,,,,,saturation_mutlist,,,,,,,,2.03279,0.3301327395439148,,1.4773013596100206,,1.7550456798050103,,Uncertain,Neutral,,Neutral,0.30853044284562986,,0.5156993868217563,0.98989,,1.4261305830608244,,1.2080102915304123,,Neutral,,Neutral,,1.1164725550250494,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,neutral,,-0.2335,1.5821,-22.2125,-4.25192970650052,0.7443999092140644,Pathogenic,0.4629,ambiguous,-3.666,available,https://doi.org/10.1101/2022.10.22.513328 +N288K,NP_000537:p.Asn288Lys,"hg38,17:g.7673756A>T",,,0.679,"COSMIC,saturation_mutlist",,,,,,,,-0.43526,0.1599143838882446,0.20408,0.09769800855577511,-0.11558999999999998,-0.16878099572211244,Neutral,Neutral,Neutral,Neutral,Neutral,0.12259714498237488,0.06944818500148149,0.10314333429217958,-0.30759,0.18344666666666667,0.460998961046676,-0.06207166666666665,0.076704480523338,Neutral,Neutral,Neutral,Neutral,0.3034001039698057,0.29257479223332994,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,neutral,,-0.1105,1.5821,-7.3398,-3.052549217434,0.0136355789763751,Benign,0.7253,pathogenic,-3.22,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N288L,NP_000537:p.Asn288Leu,,,,,saturation_mutlist,,,,,,,,0.25553,0.14752277374267575,,0.2173238408963618,,0.2364269204481809,,Neutral,Neutral,,Neutral,0.14235262778688365,,0.3042543644227229,-0.00294,,0.331550426145461,,0.1643052130727305,,Neutral,,Neutral,,0.47849757929728315,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,neutral,,-0.2399,1.5821,-22.2125,-4.07196036192907,0.5398281199790643,Uncertain,0.5194,ambiguous,-3.462,available,https://doi.org/10.1101/2022.10.22.513328 +N288M,NP_000537:p.Asn288Met,,,,,saturation_mutlist,,,,,,,,0.39252,0.18336734771728516,,0.45443426016654004,,0.42347713008327004,,Neutral,Neutral,,Neutral,0.10883973089655402,,0.18459395614999083,-0.05656,,0.6016049904753507,,0.27252249523767536,,Neutral,,Neutral,,0.3658851140279524,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,neutral,,-0.194,1.5821,-22.2125,-4.38033927386804,0.5413369731008651,Uncertain,0.5235,ambiguous,-3.702,available,https://doi.org/10.1101/2022.10.22.513328 +N288P,NP_000537:p.Asn288Pro,,,,,saturation_mutlist,,,,,,,,3.87917,0.5635825276374817,,5.01479288735528,,4.44698144367764,,Destabilizing,Neutral,,Destabilizing,0.3966716088603389,,0.485478759361609,2.37916,,4.4249015109734,,3.4020307554866998,,Uncertain,,Destabilizing,,0.968198715112078,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,uncertain,,-0.3488,1.5821,-22.2125,-5.16944952456907,0.8172289364057981,Pathogenic,0.9558,pathogenic,-3.843,available,https://doi.org/10.1101/2022.10.22.513328 +N288Q,NP_000537:p.Asn288Gln,,,,,saturation_mutlist,,,,,,,,0.04104,0.12490438938140869,,0.4934175630255117,,0.26722878151275586,,Neutral,Neutral,,Neutral,0.09515342975931984,,0.14562879529731604,-0.10041,,0.7916341750127098,,0.3456120875063549,,Neutral,,Neutral,,0.2976568863905117,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,neutral,,-0.1094,1.5821,-8.9247,-2.46228200489392,0.1263507475205952,Benign,0.7269,pathogenic,-3.359,available,https://doi.org/10.1101/2022.10.22.513328 +N288R,NP_000537:p.Asn288Arg,,,,,saturation_mutlist,,,,,,,,-0.41274,0.22645542621612547,,0.04181789850450073,,-0.18546105074774963,,Neutral,Neutral,,Neutral,0.12350996681342942,,0.13738885687046318,-0.60274,,0.2834640458569462,,-0.15963797707152694,,Neutral,,Neutral,,0.3463128194832024,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,neutral,,-0.2186,1.5821,-22.2125,-3.75938809544395,0.3173898136908225,Benign,0.8063,pathogenic,-3.446,available,https://doi.org/10.1101/2022.10.22.513328 +N288S,NP_000537:p.Asn288Ser,"hg19,17:g.7577075T>C, hg38,17:g.7673757T>C",,,0.480,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,0.29424,0.1352518367767334,0.6659833333333334,0.6066882085735978,0.4801116666666667,0.45046410428679895,Neutral,Neutral,Neutral,Neutral,Neutral,0.14018105875123132,0.031857604359957076,0.19507839140008376,0.24288,0.4058933333333334,0.8241175102511149,0.3243866666666667,0.5334987551255574,Neutral,Neutral,Neutral,Neutral,0.45069504577806146,0.2201294201755583,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,uncertain,,-0.0457,1.5821,-1.1699,-1.68739472070371,0.0007251149522593,Benign,0.3389,benign,-3.116,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N288T,NP_000537:p.Asn288Thr,"hg19,17:g.7577075T>G, hg38,17:g.7673757T>G",,,0.633,"ClinVar,saturation_mutlist",2119726,Uncertain significance,1,,,,,1.64224,0.27944430589675906,1.60079,1.100529669752263,1.621515,1.3713848348761315,Neutral,Neutral,Neutral,Neutral,Neutral,0.26189717471834945,0.0645176833640721,0.36230549035197646,0.69224,0.50034,1.178844800084708,0.59629,0.935542400042354,Neutral,Neutral,Neutral,Neutral,1.0046335288054047,0.7102719903098633,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,uncertain,,-0.1349,1.5821,-8.9247,-1.62953906750738,0.0128943147429907,Benign,0.3614,ambiguous,-3.288,available,https://doi.org/10.1101/2022.10.22.513328 +N288V,NP_000537:p.Asn288Val,,,,,saturation_mutlist,,,,,,,,1.85938,0.30639941930770875,,1.2550344135985385,,1.5572072067992693,,Neutral,Neutral,,Neutral,0.28842214639095015,,0.4111640962163631,0.95123,,1.3520680027368883,,1.1516490013684442,,Neutral,,Neutral,,1.0099897370469535,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,neutral,,-0.2268,1.5821,-22.2125,-4.21045404651123,0.6651732990723527,Uncertain,0.4933,ambiguous,-3.726,available,https://doi.org/10.1101/2022.10.22.513328 +N288W,NP_000537:p.Asn288Trp,,,,,saturation_mutlist,,,,,,,,0.64635,0.2262433552742004,,0.2374618242418016,,0.4419059121209008,,Neutral,Neutral,,Neutral,0.1723552524310607,,0.24057146735520596,-0.03154,,0.3006068615185052,,0.1345334307592526,,Neutral,,Neutral,,0.40277775935462423,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,neutral,,-0.2454,1.5821,-22.2125,-3.87100364189457,0.8570869970793673,Pathogenic,0.9465,pathogenic,-4.02,available,https://doi.org/10.1101/2022.10.22.513328 +N288Y,NP_000537:p.Asn288Tyr,"hg38,17:g.7673758T>A",,,0.665,"COSMIC,saturation_mutlist",,,,,,,,0.23523,0.2726896595954895,0.4548733333333334,0.5041821595261565,0.3450516666666667,0.36970607976307823,Neutral,Neutral,Neutral,Neutral,Neutral,0.14139101979710186,0.09405228345033534,0.2523046905458368,-0.16913,0.33650666666666673,0.562257700971298,0.08368833333333336,0.196563850485649,Neutral,Neutral,Neutral,Neutral,0.5039476588121253,0.3398721609815533,82.533,11.622,98.435,13.556,,True,82.533,,neutral,neutral,neutral,,True,98.435,,neutral,neutral,neutral,neutral,,-0.2239,1.5821,-22.2125,-3.87100364189457,0.8646730915720673,Pathogenic,0.413,ambiguous,-3.904,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L289A,NP_000537:p.Leu289Ala,,,,,saturation_mutlist,,,,,,,,0.38653,0.5509998798370361,,1.1091628766826724,,0.7478464383413362,,Neutral,Neutral,,Neutral,0.0,,0.20838046563019189,0.2732,,0.803354464373475,,0.5382772321867375,,Neutral,,Neutral,,0.5688719260426648,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.1197,2.3911,-6.5999,-1.91278806690408,3.302136100609804e-07,Benign,0.0997,benign,-2.912,available,https://doi.org/10.1101/2022.10.22.513328 +L289C,NP_000537:p.Leu289Cys,,,,,saturation_mutlist,,,,,,,,0.32946,0.3047443628311157,,1.4363754358829048,,0.8829177179414525,,Neutral,Neutral,,Neutral,0.0,,0.24385799518638945,0.12174,,1.2811383688827507,,0.7014391844413753,,Neutral,,Neutral,,0.49318481028071737,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.1127,2.3911,-7.3368,-1.70623494455017,1.3646753178569665e-06,Benign,0.1263,benign,-2.998,available,https://doi.org/10.1101/2022.10.22.513328 +L289D,NP_000537:p.Leu289Asp,,,,,saturation_mutlist,,,,,,,,0.63846,1.0250238180160522,,1.1805770467369414,,0.9095185233684707,,Neutral,Uncertain,,Neutral,0.0,,0.5086713942553351,0.70179,,0.7916053740733652,,0.7466976870366826,,Neutral,,Neutral,,0.8712934093585875,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.3209,2.3911,-22.2096,-2.95977493375603,0.0004262955400523,Benign,0.2548,benign,-3.344,available,https://doi.org/10.1101/2022.10.22.513328 +L289E,NP_000537:p.Leu289Glu,,,,,saturation_mutlist,,,,,,,,0.40615,0.8130137920379639,,0.9518860005685864,,0.6790180002842932,,Neutral,Neutral,,Neutral,0.0,,0.34377015697706687,0.40656,,0.5914160104510066,,0.49898800522550324,,Neutral,,Neutral,,0.6585267901508457,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.216,2.3911,-7.9218,-2.90914507739932,0.0001176390725746,Benign,0.165,benign,-3.244,available,https://doi.org/10.1101/2022.10.22.513328 +L289F,NP_000537:p.Leu289Phe,"hg19,17:g.7577073G>A, hg38,17:g.7673755G>A",,,0.344,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",822635,Conflicting classifications of pathogenicity,1,,,,,-0.13676,0.3573623299598694,0.8937666666666667,0.3830199510115094,0.37850333333333336,0.12312997550575469,Neutral,Neutral,Neutral,Neutral,Neutral,0.0,0.10039645157518706,0.1391059025100612,-0.15962,2.2418366666666665,0.367953499271582,1.0411083333333333,0.10416674963579099,Uncertain,Neutral,Neutral,Neutral,2.0834526314803083,0.1751097305012138,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,neutral,,-0.0289,2.3911,-1.8558,-0.0518649406727437,1.3259010445877645e-17,Benign,0.045,benign,-2.769,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L289G,NP_000537:p.Leu289Gly,,,,,saturation_mutlist,,,,,,,,0.45433,0.9038373827934264,,1.774625918494726,,1.114477959247363,,Neutral,Neutral,,Neutral,0.0,,0.4698705156118161,0.16199,,1.3062947602306156,,0.7341423801153079,,Neutral,,Neutral,,0.8145860070926194,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.2064,2.3911,-8.9217,-4.45423768418131,0.0010703884232121,Benign,0.1814,benign,-3.312,available,https://doi.org/10.1101/2022.10.22.513328 +L289H,NP_000537:p.Leu289His,,,,,saturation_mutlist,,,,,,,,0.43614,0.7554745078086853,0.6155366666666667,0.5016705417488949,0.5258383333333334,0.46890527087444744,Neutral,Neutral,Neutral,Neutral,Neutral,0.0,0.14203455784499147,0.31189039275741753,0.23244,2.04592,0.38267376365264855,1.13918,0.3075568818263243,Uncertain,Neutral,Neutral,Neutral,1.6182729617094886,0.40576940354102653,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.1637,2.3911,-6.9218,-1.24336967944645,2.6568607771408306e-08,Benign,0.068,benign,-2.896,available,https://doi.org/10.1101/2022.10.22.513328 +L289I,NP_000537:p.Leu289Ile,"hg19,17:g.7577073G>T, hg38,17:g.7673755G>T",,,0.349,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1439164,Conflicting classifications of pathogenicity,1,,,,,0.18144,0.1244581937789917,0.30850666666666665,0.4885896498313291,0.24497333333333332,0.33501482491566453,Neutral,Neutral,Neutral,Neutral,Neutral,0.0,0.1503931590495023,0.12897953748323338,0.38707,0.6453533333333333,0.3478424520891821,0.5162116666666667,0.36745622604459105,Neutral,Neutral,Neutral,Neutral,0.30858872406849575,0.2525972714413671,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,0.0338,2.3911,-1.2007,-1.60048211038511,3.6485715389777325e-05,Benign,0.0693,benign,-2.953,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L289K,NP_000537:p.Leu289Lys,,,,,saturation_mutlist,,,,,,,,-0.00013,0.6778944134712219,,0.6753247830301862,,0.3375973915150931,,Neutral,Neutral,,Neutral,0.0,,0.28659363282029776,-0.25088,,0.5539757427147681,,0.15154787135738407,,Neutral,,Neutral,,0.5201867057511671,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.2048,2.3911,-5.9218,-2.24982461265809,5.379416805166446e-07,Benign,0.1533,benign,-3.06,available,https://doi.org/10.1101/2022.10.22.513328 +L289M,NP_000537:p.Leu289Met,,,,,saturation_mutlist,,,,,,,,-0.16774,0.3234715461730957,,0.4459228489819611,,0.13909142449098055,,Neutral,Neutral,,Neutral,0.0,,0.19196172621148055,-0.2307,,0.35824684902836307,,0.06377342451418154,,Neutral,,Neutral,,0.16913051075890953,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.0238,2.3911,-7.9218,-2.12240502187225,3.114518312370854e-06,Benign,0.0799,benign,-3.114,available,https://doi.org/10.1101/2022.10.22.513328 +L289N,NP_000537:p.Leu289Asn,,,,,saturation_mutlist,,,,,,,,0.44331,0.886358916759491,,0.7669598981732481,,0.605134949086624,,Neutral,Neutral,,Neutral,0.0,,0.40486582139375366,0.27514,,0.6585100331069308,,0.4668250165534654,,Neutral,,Neutral,,0.6560852240955513,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.1891,2.3911,-6.9218,-2.24758048965414,8.3340997540258e-08,Benign,0.1383,benign,-3.009,available,https://doi.org/10.1101/2022.10.22.513328 +L289P,NP_000537:p.Leu289Pro,"hg19,17:g.7577072A>G, hg38,17:g.7673754A>G",,,0.518,"COSMIC,ClinVar,saturation_mutlist",1172923,Likely benign,3,,,,,2.27557,1.0247747898101809,2.4174566666666664,4.766191935466844,2.3465133333333332,3.520880967733422,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,0.0,0.27777576236157736,1.3530011415709593,1.06315,1.2127000000000001,2.1034826469528176,1.137925,1.5833163234764087,Neutral,Uncertain,Neutral,Neutral,1.1691228456411245,1.5776994598109384,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.2149,2.3911,-8.9217,-3.21706676650494,0.0025888532731495,Benign,0.5712,pathogenic,-3.338,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L289Q,NP_000537:p.Leu289Gln,,,,,saturation_mutlist,,,,,,,,0.15954,0.7709410190582275,,0.9070623290841521,,0.533301164542076,,Neutral,Neutral,,Neutral,0.0,,0.22117642220597497,0.02528,,0.7308183762235011,,0.37804918811175053,,Neutral,,Neutral,,0.4745851862696396,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.1421,2.3911,-6.9218,-2.05387898137269,2.127024279428295e-07,Benign,0.0722,benign,-2.972,available,https://doi.org/10.1101/2022.10.22.513328 +L289R,NP_000537:p.Leu289Arg,"hg38,17:g.7673754A>C",,,0.426,"COSMIC,saturation_mutlist",,,,,,,,-0.0034,0.6902971267700195,0.4700666666666667,0.4412635153538312,0.23333333333333334,0.21893175767691558,Neutral,Neutral,Neutral,Neutral,Neutral,0.0,0.4462760294805098,0.25988411265053757,-0.35053,0.8498866666666668,0.4345715410526485,0.2496783333333334,0.04202077052632425,Neutral,Neutral,Neutral,Neutral,1.3514925609940376,0.38221776762351156,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,neutral,,-0.2015,2.3911,-6.9218,-2.0685432144847,2.2452354781232724e-06,Benign,0.0864,benign,-3.074,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L289S,NP_000537:p.Leu289Ser,,,,,saturation_mutlist,,,,,,,,0.56793,0.7774978876113892,,1.2368707799415353,,0.9024003899707677,,Neutral,Neutral,,Neutral,0.0,,0.48054374353308477,0.19017,,0.7180815613587436,,0.4541257806793718,,Neutral,,Neutral,,0.6286108055415814,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.1395,2.3911,-4.5295,-0.684918839668213,9.875814785988222e-10,Benign,0.1004,benign,-2.84,available,https://doi.org/10.1101/2022.10.22.513328 +L289T,NP_000537:p.Leu289Thr,,,,,saturation_mutlist,,,,,,,,0.6093,0.5381551384925842,,1.1320292583528369,,0.8706646291764184,,Neutral,Neutral,,Neutral,0.0,,0.3512155924230791,0.19902,,0.6662950563642894,,0.4326575281821447,,Neutral,,Neutral,,0.5484917723653749,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.1347,2.3911,-8.9217,-1.87781748568653,2.488889226828999e-05,Benign,0.1149,benign,-3.085,available,https://doi.org/10.1101/2022.10.22.513328 +L289V,NP_000537:p.Leu289Val,"hg19,17:g.7577073G>C, hg38,17:g.7673755G>C",,,0.399,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",496049,Conflicting classifications of pathogenicity,1,,,,,0.4784,0.2853518724441528,0.42494666666666664,0.6108661242478037,0.4516733333333333,0.5446330621239018,Neutral,Neutral,Neutral,Neutral,Neutral,0.0,0.3616568810657724,0.1888258816465733,0.60814,1.1045333333333334,0.5085160640164813,0.8563366666666667,0.5583280320082407,Neutral,Neutral,Neutral,Neutral,0.5688926690412602,0.39268339844577616,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,uncertain,,-0.0368,2.3911,-7.9218,-1.62282686049212,2.151504363397156e-06,Benign,0.064,benign,-3.002,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L289W,NP_000537:p.Leu289Trp,,,,,saturation_mutlist,,,,,,,,0.18578,0.3816654086112976,,0.14982035822105366,,0.16780017911052683,,Neutral,Neutral,,Neutral,0.0,,0.09335500679009281,0.33724,,0.12001199344525487,,0.22862599672262743,,Neutral,,Neutral,,0.2544521651742107,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,neutral,,-0.2319,2.3911,-22.2096,-2.81518494983562,0.0524256575702248,Benign,0.0886,benign,-3.415,available,https://doi.org/10.1101/2022.10.22.513328 +L289Y,NP_000537:p.Leu289Tyr,,,,,saturation_mutlist,,,,,,,,-0.09961,0.4366292357444763,,0.4954334190562674,,0.1979117095281337,,Neutral,Neutral,,Neutral,0.0,,0.15451439653423232,0.15478,,0.44243296240590996,,0.29860648120295497,,Neutral,,Neutral,,0.2394150282758051,93.404,20.509,77.24,24.115,,True,93.404,,neutral,neutral,neutral,,True,77.24,,neutral,neutral,neutral,neutral,,-0.1277,2.3911,-3.167,-0.545901498345077,4.4341865407177116e-08,Benign,0.0849,benign,-2.936,available,https://doi.org/10.1101/2022.10.22.513328 diff --git a/dot_plot/examples_v2/ensemble_mode_popeve/dictionary.csv b/dot_plot/examples_v2/ensemble_mode_popeve/dictionary.csv new file mode 100644 index 0000000..997026d --- /dev/null +++ b/dot_plot/examples_v2/ensemble_mode_popeve/dictionary.csv @@ -0,0 +1,178 @@ +#ClinVar Internal_dictionary +Benign Benign +nan Uncertain +Uncertain significance,not specified Uncertain +Uncertain significance,Pathogenic Conflicting interpretation +Conflicting interpretations of pathogenicity Conflicting interpretation +Uncertain significance,Likely pathogenic,Likely pathogenic Conflicting interpretation +Conflicting interpretations of pathogenicity,Conflicting interpretations of pathogenicity Conflicting interpretation +Conflicting interpretations of pathogenicity,Uncertain significance Conflicting interpretation +Uncertain significance,Uncertain significance,Conflicting interpretations of pathogenicity Conflicting interpretation +Uncertain significance,Conflicting interpretations of pathogenicity,Uncertain significance Conflicting interpretation +Pathogenic/Likely pathogenic,Conflicting interpretations of pathogenicity Conflicting interpretation +Conflicting interpretations of pathogenicity,Pathogenic/Likely pathogenic Conflicting interpretation +Likely benign,Likely benign,Conflicting interpretations of pathogenicity Conflicting interpretation +Likely pathogenic,Uncertain significance,Pathogenic/Likely pathogenic Conflicting interpretation +Uncertain significance,Likely pathogenic Conflicting interpretation +Conflicting interpretations of pathogenicity,Conflicting interpretations of pathogenicity,Conflicting interpretations of pathogenicity Conflicting interpretation +Uncertain significance,Uncertain significance,Likely pathogenic Conflicting interpretation +Uncertain significance,Conflicting interpretations of pathogenicity,Likely pathogenic Conflicting interpretation +Uncertain significance,Pathogenic/Likely pathogenic Conflicting interpretation +Likely benign,Conflicting interpretations of pathogenicity Conflicting interpretation +Uncertain significance,Likely benign Conflicting interpretation +Uncertain significance,Conflicting interpretations of pathogenicity,Conflicting interpretations of pathogenicity Conflicting interpretation +Pathogenic,Conflicting interpretations of pathogenicity Conflicting interpretation +Likely benign,Uncertain significance Conflicting interpretation +Likely pathogenic,Uncertain significance Conflicting interpretation +Uncertain significance,Conflicting interpretations of pathogenicity Conflicting interpretation +Uncertain significance,Benign/Likely benign Conflicting interpretation +Uncertain significance,Likely pathogenic,Uncertain significance Conflicting interpretation +Conflicting interpretations of pathogenicity,Likely pathogenic Conflicting interpretation +Likely pathogenic,Conflicting interpretations of pathogenicity Conflicting interpretation +Pathogenic,Uncertain significance Conflicting interpretation +Likely benign Likely benign +Benign/Likely benign Likely benign +Likely benign,Benign/Likely benign Likely benign +Benign/Likely benign,Benign/Likely benign Likely benign +Likely benign,Benign Likely benign +Likely benign,Likely benign Likely benign +Pathogenic/Likely pathogenic,Pathogenic,Pathogenic Likely pathogenic +Likely pathogenic,drug response Likely pathogenic +Likely pathogenic,Pathogenic Likely pathogenic +Likely pathogenic Likely pathogenic +Pathogenic, Pathogenic/Likely pathogenic Likely pathogenic +Likely pathogenic, Likely pathogenic, drug response Likely pathogenic +Pathogenic/Likely pathogenic, Likely pathogenic Likely pathogenic +Pathogenic/Likely pathogenic Likely pathogenic +Pathogenic/Likely pathogenic, Pathogenic/Likely pathogenic Likely pathogenic +Pathogenic/Likely pathogenic; risk factor Likely pathogenic +Pathogenic, Likely pathogenic, Pathogenic Likely pathogenic +Likely pathogenic, Likely pathogenic, Likely pathogenic Likely pathogenic +Likely pathogenic, Pathogenic/Likely pathogenic Likely pathogenic +Likely pathogenic,risk factor Likely pathogenic +Pathogenic/Likely pathogenic,drug response Likely pathogenic +Likely pathogenic,Pathogenic,drug response,other Likely pathogenic +Pathogenic/Likely pathogenic,Pathogenic Likely pathogenic +Likely pathogenic,Likely pathogenic Likely pathogenic +Pathogenic,Likely pathogenic Likely pathogenic +not provided Uncertain +Pathogenic,Pathogenic,Pathogenic Pathogenic +Pathogenic,risk factor Pathogenic +Pathogenic,Pathogenic Pathogenic +Pathogenic Pathogenic +Uncertain significance,Uncertain significance,Uncertain significance Uncertain +Uncertain significance,not provided Uncertain +drug response Drug response +Uncertain significance Uncertain +Uncertain significance,Uncertain significance Uncertain +Uncertain significance,drug response Uncertain +protective Protective +not provided,Pathogenic/Likely pathogenic Likely pathogenic +Uncertain significance,not provided,not provided Uncertain +not provided,not provided,not provided Uncertain +Uncertain significance,Uncertain significance,Conflicting classifications of pathogenicity Uncertain +not provided,not provided,Uncertain significance Uncertain +Benign,Uncertain significance Uncertain +Likely benign,not provided Likely benign +not provided,Uncertain significance,Conflicting classifications of pathogenicity Uncertain +Likely pathogenic,Tier I - Strong Likely pathogenic +Likely pathogenic; drug response Likely pathogenic +Pathogenic,Pathogenic/Likely pathogenic Likely pathogenic +Conflicting classifications of pathogenicity Uncertain +Likely pathogenic,Conflicting classifications of pathogenicity Uncertain +Conflicting classifications of pathogenicity,Benign Uncertain +Likely pathogenic,Likely pathogenic,drug response Likely pathogenic +Uncertain significance,not provided,Uncertain significance Uncertain +Likely pathogenic,Pathogenic/Likely pathogenic,Pathogenic,Pathogenic Likely pathogenic +not provided,Benign Uncertain +not provided,Conflicting classifications of pathogenicity Uncertain +risk factor Risk Factor +Likely pathogenic,not provided Likely pathogenic +not provided,not provided,Conflicting classifications of pathogenicity Uncertain +Pathogenic,Likely pathogenic,Pathogenic Likely pathogenic +Uncertain significance,Benign Uncertain +not provided,Pathogenic Pathogenic +Likely pathogenic; risk factor Likely pathogenic +Conflicting interpretations of pathogenicity,Pathogenic Uncertain +Benign,Conflicting interpretations of pathogenicity Uncertain +Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity Uncertain +not provided,Conflicting classifications of pathogenicity,Uncertain significance Uncertain +Benign,Benign Benign +Benign,Likely benign Likely benign +Pathogenic/Likely pathogenic; drug response Likely pathogenic +Likely benign,Likely benign,Conflicting classifications of pathogenicity Uncertain +Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity,Likely pathogenic Uncertain +Uncertain significance; drug response Uncertain +not provided,not provided,Conflicting interpretations of pathogenicity Uncertain +Pathogenic/Likely pathogenic,Likely pathogenic Likely pathogenic +Likely oncogenic Likely pathogenic +Pathogenic/Likely pathogenic,Pathogenic/Likely pathogenic Likely pathogenic +Likely pathogenic,Likely pathogenic,drug response,Tier I - Strong Likely pathogenic +Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity,Benign Uncertain +not provided,Conflicting interpretations of pathogenicity,Uncertain significance Uncertain +Likely pathogenic,Likely pathogenic,Likely pathogenic Likely pathogenic +not provided,Conflicting interpretations of pathogenicity,Conflicting interpretations of pathogenicity Uncertain +no interpretation for the single variant,Pathogenic Pathogenic +Conflicting classifications of pathogenicity,Pathogenic Uncertain +Likely benign,Conflicting classifications of pathogenicity Uncertain +Likely benign,not provided,Conflicting classifications of pathogenicity Uncertain +other Uncertain +Conflicting classifications of pathogenicity,not provided Uncertain +Uncertain significance,Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity Uncertain +Pathogenic; risk factor Pathogenic +Pathogenic/Likely pathogenic,Pathogenic/Likely pathogenic,Pathogenic Likely pathogenic +Likely benign,Benign/Likely benign,Benign Likely benign +Likely pathogenic,Pathogenic,Pathogenic Likely pathogenic +not provided,not provided,Likely pathogenic Likely pathogenic +Benign,Conflicting classifications of pathogenicity Uncertain +Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity Uncertain +not provided,Conflicting interpretations of pathogenicity Uncertain +Conflicting interpretations of pathogenicity,Benign Uncertain +Likely benign,Pathogenic Uncertain +Conflicting classifications of pathogenicity,Uncertain significance Uncertain +Likely pathogenic,Pathogenic/Likely pathogenic,Tier I - Strong Uncertain +Uncertain significance,Uncertain significance,Likely benign Uncertain +Likely benign,Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity Uncertain +Pathogenic; other Uncertain +Pathogenic/Likely pathogenic/Pathogenic, low penetrance/Established risk allele Likely pathogenic +Benign/Likely benign,Conflicting interpretations of pathogenicity Uncertain +Likely pathogenic/Likely risk allele Likely pathogenic +Benign/Likely benign,Conflicting classifications of pathogenicity Uncertain +Conflicting classifications of pathogenicity,Pathogenic/Likely pathogenic Uncertain +Uncertain significance,other Uncertain +Conflicting interpretations of pathogenicity,Likely benign Uncertain +Conflicting classifications of pathogenicity,Likely pathogenic Uncertain +not provided,not provided,Benign Benign +Likely pathogenic,Pathogenic/Likely pathogenic Likely pathogenic +Uncertain significance; risk factor Uncertain +Pathogenic/Likely pathogenic,Conflicting classifications of pathogenicity Uncertain +Benign,Benign/Likely benign Likely benign +Conflicting classifications of pathogenicity,Uncertain significance,Uncertain significance Uncertain +Conflicting classifications of pathogenicity,Likely benign Uncertain +Likely risk allele Likely risk +Uncertain risk allele Uncertain risk +Conflicting interpretations of pathogenicity,Conflicting interpretations of pathogenicity,Benign Uncertain +Pathogenic,Pathogenic; risk factor Pathogenic +Conflicting classifications of pathogenicity; association; risk factor Uncertain +not provided,Likely pathogenic Likely pathogenic +Benign/Likely benign,Benign Likely benign +Conflicting interpretations of pathogenicity; risk factor Uncertain +not provided,Likely benign Likely benign +Uncertain significance/Uncertain risk allele Uncertain +not provided,Uncertain significance,Conflicting interpretations of pathogenicity Uncertain +Uncertain significance,Conflicting classifications of pathogenicity,Uncertain significance Uncertain +Pathogenic,Conflicting classifications of pathogenicity Uncertain +not provided,Uncertain significance Uncertain +Uncertain significance,Conflicting classifications of pathogenicity Uncertain +Likely benign,Likely benign,Benign Likely benign +Conflicting classifications of pathogenicity; risk factor Uncertain +not provided,Pathogenic,not provided Pathogenic +Pathogenic,not provided,Likely pathogenic Likely pathogenic +not provided,not provided Uncertain +not provided,Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity Uncertain +Pathogenic/Likely pathogenic,Uncertain significance,Pathogenic Uncertain +Likely pathogenic,Pathogenic; drug response; other Likely pathogenic +Benign,Likely benign,Benign Benign +Conflicting classifications of pathogenicity,Tier II - Potential Uncertain +Conflicting classifications of pathogenicity,Uncertain significance,Conflicting classifications of pathogenicity Uncertain +no interpretation for the single variant Uncertain diff --git a/dot_plot/examples_v2/ensemble_mode_popeve/do.sh b/dot_plot/examples_v2/ensemble_mode_popeve/do.sh new file mode 100644 index 0000000..06376b5 --- /dev/null +++ b/dot_plot/examples_v2/ensemble_mode_popeve/do.sh @@ -0,0 +1,3 @@ +module load python + +python ../../dot_plot_v2.py -i TP53-ensemble_mode.csv -x 50 -pltD -pltR -pltP -colC -vep -lgof -cct germline -v dictionary.csv diff --git a/dot_plot/examples_v2/ensemble_mode_popeve/dot_plot.pdf b/dot_plot/examples_v2/ensemble_mode_popeve/dot_plot.pdf new file mode 100644 index 0000000..7daa654 Binary files /dev/null and b/dot_plot/examples_v2/ensemble_mode_popeve/dot_plot.pdf differ diff --git a/dot_plot/examples_v2/ensemble_mode_popeve/log.txt b/dot_plot/examples_v2/ensemble_mode_popeve/log.txt new file mode 100644 index 0000000..29acfd7 --- /dev/null +++ b/dot_plot/examples_v2/ensemble_mode_popeve/log.txt @@ -0,0 +1,121 @@ +Summary of the effects. + +>>> UNCERTAIN effects: + +- 0 variants remain uncertain for Stability (ThermoMPNN, kcal/mol) [md]. [] +- 317 variants remain uncertain for Stability classification, (Rosetta, FoldX) [md]. See csv file for details. +- 962 variants remain uncertain for Stability classification, (RaSP, FoldX) [md]. See csv file for details. +- 929 variants remain uncertain for Stability classification (ThermoMPNN) [md]. See csv file for details. +- 153 variants remain uncertain for Stability classification (Foldetta from FoldX and Rosetta) [md]. See csv file for details. +- 381 variants remain uncertain for Stability classification (Foldetta from FoldX and RaSP) [md]. See csv file for details. +- 0 variants remain uncertain for Stability (ThermoMPNN, kcal/mol, st. dev.) [md]. [] +- 361 variants remain uncertain for Stability classification, (Rosetta, FoldX) [cabsflex]. See csv file for details. +- 1222 variants remain uncertain for Stability classification, (RaSP, FoldX) [cabsflex]. See csv file for details. +- 120 variants remain uncertain for Stability classification (Foldetta from FoldX and Rosetta) [cabsflex]. See csv file for details. +- 311 variants remain uncertain for Stability classification (Foldetta from FoldX and RaSP) [cabsflex]. See csv file for details. +- No classification for LOCAL_INTERACTION available yet. +- 19 variants remain uncertain for PTM-stability. [md] See csv file for details. + - 45 variants remain uncertain for PTM-stability. [cabsflex] See csv file for details. + - 612 variants remain uncertain for PTM-regulation. [md] See csv file for details. + - 593 variants remain uncertain for PTM-regulation. [cabsflex] See csv file for details. + - 95 variants remain uncertain for PTM-function. [md] See csv file for details. + - 114 variants remain uncertain for PTM-function. [cabsflex] See csv file for details. + - 2044 variants remain uncertain for Long Range-PSN. [md] See csv file for details. + - 0 variants could not be classified with any of the MAVISp modules.[] + +>>> DAMAGING/DESTABILIZING effects: + +- 0 variants are predicted with damaging effects for Stability (ThermoMPNN, kcal/mol) [md]. [] +-- 0 of these are vus according to ClinVar Germline Interpretation: [] +-- 0 of these have conflicting interpretations according to ClinVar Germline Interpretation: [] +- 146 variants are predicted with damaging effects for Stability classification, (Rosetta, FoldX) [md]. See csv file for details. +-- 20 of these are vus according to ClinVar Germline Interpretation: See csv file for details. +-- 49 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 385 variants are predicted with damaging effects for Stability classification, (RaSP, FoldX) [md]. See csv file for details. +-- 19 of these are vus according to ClinVar Germline Interpretation: See csv file for details. +-- 42 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 448 variants are predicted with damaging effects for Stability classification (ThermoMPNN) [md]. See csv file for details. +-- 25 of these are vus according to ClinVar Germline Interpretation: See csv file for details. +-- 43 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 215 variants are predicted with damaging effects for Stability classification (Foldetta from FoldX and Rosetta) [md]. See csv file for details. +-- 34 of these are vus according to ClinVar Germline Interpretation: See csv file for details. +-- 67 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 595 variants are predicted with damaging effects for Stability classification (Foldetta from FoldX and RaSP) [md]. See csv file for details. +-- 28 of these are vus according to ClinVar Germline Interpretation: See csv file for details. +-- 66 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 0 variants are predicted with damaging effects for Stability (ThermoMPNN, kcal/mol, st. dev.) [md]. [] +-- 0 of these are vus according to ClinVar Germline Interpretation: [] +-- 0 of these have conflicting interpretations according to ClinVar Germline Interpretation: [] +- 103 variants are predicted with damaging effects for Stability classification, (Rosetta, FoldX) [cabsflex]. See csv file for details. +-- 11 of these are vus according to ClinVar Germline Interpretation: See csv file for details. +-- 28 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 149 variants are predicted with damaging effects for Stability classification, (RaSP, FoldX) [cabsflex]. See csv file for details. +-- 4 of these are vus according to ClinVar Germline Interpretation: ['F134S', 'Q167P', 'V216E', 'G279V'] +-- 14 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 179 variants are predicted with damaging effects for Stability classification (Foldetta from FoldX and Rosetta) [cabsflex]. See csv file for details. +-- 20 of these are vus according to ClinVar Germline Interpretation: See csv file for details. +-- 56 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 505 variants are predicted with damaging effects for Stability classification (Foldetta from FoldX and RaSP) [cabsflex]. See csv file for details. +-- 10 of these are vus according to ClinVar Germline Interpretation: ['M133R', 'F134S', 'L145R', 'A159F', 'Q167P', 'L194P', 'V197E', 'V216E', 'I255S', 'G279V'] +-- 39 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- No classification for LOCAL_INTERACTION available yet. +- 74 variants are predicted with damaging effects on stability after the removal of a PTM. [md] See csv file for details. + - 56 variants are predicted with damaging effects on stability after the removal of a PTM. [cabsflex] See csv file for details. + - 153 variants are likely to alter the regulation provided by a phosphorylation. [md] See csv file for details. + - 172 variants are likely to alter the regulation provided by a phosphorylation. [cabsflex] See csv file for details. + - 152 variants are potentially damaging in terms of removing the function related to a phosphorylation. [md] See csv file for details. + - 133 variants are potentially damaging in terms of removing the function related to a phosphorylation. [cabsflex] See csv file for details. + - 591 variants are predicted with damaging long range effects on pocket site(s). [md] See csv file for details. + - Variants with multiple effects: +-- A138P, I195R, Y205Q, V197N, V173S, Y236K, Y205K, Y205I, P222R, Y107D, R110D, I232Q, H193R, H193W, F270K, Y220A, F113K, H179Y, F270H, F113V, Y234G, Y236A, H179F, P190H, Y205L, F113W, P222F, Y234D, Y236T, P151R, Q165P, F113P, Y220G, V203P, P151F, R196P, Y205A, I232A, F113R, Y236P, P151K, V203W, Y107S, F113E, V218P, V173D, P151S, Y107R, Y220N, V203F, Y220S, I232Y, F113T, Y107K, Y236G, F270A, I232P, V197K, I195W, P190R, Y220P, Y236H, V197A, Y205V, F270D, F113C, M160P, Y220R, R158G, R158H, H168P, V203D, Y103G, P151H, V203N, Y205G, Y234P, P98R, H193P, H179W, I232R, Y107Q, F270S, F113D, N200Y, Y236R, Y205M, R196Y, V203H, V197Y, V218D, C275F, V197G, V216N, F270N, I232T, V203M, Y205N, R158Y, Y107A, M237K, Y220D, Y234A, V197D, Y107V, I232N, R158P, I195Y, V203G, M237P, P151W, C275Y, P190F, V197H, F270T, Y220Q, F113I, H179R, Y205C, V216D, P190W, H193Y, E198P, M160G, V203K, F113G, Y234T, V197F, F270R, V216S, I195F, C275W, Y220E, P222Y, P151G, F270C, Y205T, I232H, R249P, Y236D, F270P, P222K, Y234S, Y234N, V218G, I232G, R158D, C275H, Y205D, I232D, Q136P, H179P, Y236E, Y220K, Y220T, Y234Q, Y107G, Y236S, N200W, Y205E, Y234E, Y107P, V203Y, R110P, V216G, Y205R, P222W, Y107E, Y103P, Y107T, I232E, V173G, V216P, F113Q, Y220C, Y234R, Y234K, Y205P, C275K, R196H, V197P, P151Y, V197W, F270G, I232W, P222H, Q136D, V218N, R175H, F113N, F270E, Y236N, V197S, Y236Q, V203R, V197R, F113A, V218S, I232F, F270V, Y205S, F270Q, F113S, Y234C, Y205H, Y236C, I232S, C275R -> [stability, long_range] +-- Y220N, Y220S, T211P, T155G, T155N, Y220P, Y220Q, Y220D, S149P, T155P, Y220A, Y220R, Y220C, Y220E, R249P, Y220T, Y220G, T284P, Y220K -> [stability, ptm] +-- Y220N, Y220S, R249L, R249D, Y220P, Y220Q, Y220D, Y220V, Y220H, R249C, R249I, R249V, R249M, Y220A, Y220R, Y220C, R249S, Y220M, R249Q, R249T, R249G, Y220E, R249N, R249Y, Y220I, R249W, R249P, Y220T, R249F, Y220G, R249E, R249H, R249A, Y220L, Y220K -> [long_range, ptm] +-- Y220N, Y220S, Y220E, Y220A, Y220R, Y220C, Y220Q, R249P, Y220P, Y220K, Y220T, Y220D, Y220G -> [stability, long_range, ptm] +- We aggregated all the variants that have at least one of the MAVISp modules with a predicted damaging effect (except for PTM.function) and retained only the ones with a REVEL score higher than 0.5 for a total of 376 variants which could be of interest for further investigation: +-- ['S94P', 'S96P', 'P98A', 'P98H', 'P98L', 'P98R', 'P98S', 'S99C', 'S99F', 'S99P', 'Y103C', 'Y103H', 'Y103N', 'Y103S', 'G105C', 'G105D', 'G105R', 'G105S', 'G105V', 'S106R', 'Y107C', 'Y107D', 'Y107H', 'Y107N', 'Y107S', 'G108C', 'G108D', 'G108R', 'G108S', 'G108V', 'F109C', 'F109I', 'F109S', 'F109V', 'R110G', 'R110H', 'R110L', 'R110P', 'R110S', 'L111P', 'L111Q', 'L111R', 'F113C', 'F113L', 'F113S', 'S121P', 'C124F', 'C124R', 'C124W', 'C124Y', 'T125A', 'T125K', 'T125P', 'T125R', 'T125S', 'Y126C', 'Y126D', 'Y126H', 'Y126N', 'Y126S', 'S127F', 'S127P', 'S127Y', 'L130P', 'N131I', 'M133K', 'M133R', 'M133T', 'F134C', 'F134S', 'C135F', 'C135R', 'C135W', 'C135Y', 'Q136E', 'Q136H', 'Q136K', 'Q136L', 'Q136P', 'Q136R', 'A138D', 'A138P', 'A138T', 'A138V', 'C141F', 'C141G', 'C141R', 'C141W', 'C141Y', 'P142H', 'V143A', 'V143E', 'V143G', 'Q144P', 'L145P', 'L145Q', 'L145R', 'V147D', 'V147F', 'V147G', 'S149P', 'P151A', 'P151H', 'P151L', 'P151R', 'P151S', 'G154V', 'T155I', 'T155N', 'T155P', 'R156P', 'V157A', 'V157D', 'V157F', 'V157G', 'R158C', 'R158G', 'R158H', 'R158L', 'R158P', 'R158S', 'A159D', 'A159P', 'M160K', 'M160R', 'M160T', 'M160V', 'A161D', 'I162F', 'I162N', 'Y163C', 'Y163D', 'Y163N', 'Y163S', 'Q165E', 'Q165P', 'Q167P', 'H168D', 'H168L', 'H168N', 'H168P', 'H168Q', 'H168R', 'H168Y', 'V172F', 'V173A', 'V173E', 'V173G', 'V173M', 'R175C', 'R175G', 'R175H', 'R175L', 'R175P', 'R175S', 'C176F', 'C176R', 'C176W', 'C176Y', 'H178P', 'H179D', 'H179L', 'H179N', 'H179P', 'H179Q', 'H179R', 'H179Y', 'R181P', 'S183L', 'S185R', 'D186E', 'D186G', 'D186H', 'D186V', 'G187V', 'A189G', 'A189P', 'P190A', 'P190H', 'P190L', 'P190R', 'P190S', 'P191H', 'Q192E', 'Q192H', 'Q192K', 'Q192L', 'Q192P', 'Q192R', 'H193D', 'H193L', 'H193N', 'H193P', 'H193Q', 'H193R', 'H193Y', 'L194F', 'L194H', 'L194P', 'L194R', 'I195F', 'I195N', 'I195S', 'I195T', 'R196G', 'R196L', 'R196P', 'R196Q', 'V197A', 'V197E', 'V197G', 'V197L', 'V197M', 'E198D', 'E198G', 'E198K', 'E198Q', 'G199V', 'N200H', 'N200I', 'N200S', 'N200Y', 'V203A', 'V203E', 'V203L', 'V203M', 'Y205C', 'Y205D', 'Y205H', 'Y205N', 'Y205S', 'D208G', 'D208Y', 'T211A', 'T211I', 'T211N', 'T211P', 'R213P', 'S215C', 'S215G', 'S215I', 'S215N', 'S215T', 'V216A', 'V216E', 'V216G', 'V216M', 'V217G', 'V218A', 'V218E', 'V218G', 'Y220C', 'Y220D', 'Y220H', 'Y220N', 'Y220S', 'P222L', 'P222Q', 'P223H', 'P223R', 'G226V', 'S227P', 'C229W', 'T230P', 'I232F', 'I232N', 'I232S', 'I232T', 'H233P', 'Y234C', 'Y234D', 'Y234H', 'Y234N', 'Y234S', 'Y236C', 'Y236D', 'Y236H', 'Y236N', 'Y236S', 'M237K', 'M237R', 'M237T', 'M237V', 'C238F', 'C238R', 'C238W', 'C238Y', 'S241P', 'C242F', 'C242R', 'C242W', 'C242Y', 'G244C', 'G244V', 'G245C', 'G245D', 'G245R', 'G245S', 'G245V', 'M246K', 'M246R', 'N247I', 'R248P', 'R249G', 'R249K', 'R249M', 'R249S', 'R249T', 'R249W', 'I251F', 'I251N', 'I251S', 'I251T', 'L252H', 'L252P', 'T253P', 'I254F', 'I254N', 'I254S', 'I255N', 'I255S', 'I255T', 'T256P', 'L257P', 'L257Q', 'L257R', 'E258D', 'D259A', 'D259E', 'D259H', 'D259V', 'D259Y', 'G262V', 'L265P', 'L265Q', 'L265R', 'G266E', 'G266R', 'G266V', 'R267G', 'R267P', 'R267W', 'F270C', 'F270I', 'F270L', 'F270S', 'F270V', 'V272A', 'V272E', 'V272G', 'R273P', 'V274D', 'V274F', 'V274G', 'C275F', 'C275G', 'C275R', 'C275S', 'C275W', 'C275Y', 'P278H', 'P278L', 'P278R', 'P278S', 'P278T', 'G279E', 'G279R', 'G279V', 'G279W', 'D281G', 'R282P', 'R283P', 'T284I', 'T284P', 'T284R', 'L289P'] +- We aggregated all the variants that have at least one of the MAVISp modules with a predicted damaging effect (except for PTM.function) and retained only the ones with a popEVE score < -4.617 for a total of 192 variants which could be of interest for further investigation: +-- ['F109D', 'F109E', 'F109G', 'F109K', 'F109N', 'F109R', 'F134E', 'C135D', 'C135E', 'C135H', 'C135K', 'C135P', 'C135Q', 'Q136W', 'Q136Y', 'A138W', 'C141E', 'C141K', 'V143D', 'V143E', 'V143K', 'A161W', 'Y163E', 'V173D', 'V173K', 'V173W', 'V173Y', 'R175D', 'C176I', 'C176K', 'C176M', 'C176N', 'C176P', 'C176Q', 'C176V', 'C176W', 'H193E', 'H193G', 'H193I', 'H193M', 'H193V', 'H193W', 'L194D', 'L194G', 'L194K', 'L194N', 'I195W', 'E198W', 'G199I', 'T211W', 'V216D', 'V216K', 'V216R', 'V218K', 'V218W', 'Y220D', 'Y220E', 'Y220K', 'T230W', 'Y234D', 'Y234E', 'Y234K', 'Y234P', 'M237D', 'M237E', 'M237W', 'C238F', 'C238H', 'C238K', 'C238P', 'C238R', 'C238W', 'C238Y', 'S240W', 'S240Y', 'C242F', 'C242H', 'C242I', 'C242K', 'C242L', 'C242M', 'C242N', 'C242P', 'C242Q', 'C242R', 'C242T', 'C242V', 'C242W', 'C242Y', 'G244I', 'G245L', 'G245P', 'G245W', 'G245Y', 'R249A', 'R249D', 'R249F', 'R249I', 'R249P', 'R249V', 'R249Y', 'I251D', 'I251E', 'I251G', 'I251H', 'I251K', 'I251Q', 'I251R', 'I251W', 'I251Y', 'T253W', 'I254D', 'I254E', 'I254G', 'I254H', 'I254K', 'I254N', 'I254P', 'I254R', 'I254W', 'I254Y', 'I255D', 'I255E', 'I255K', 'I255P', 'I255R', 'L257D', 'L257E', 'L257G', 'L257K', 'L257N', 'L257R', 'L257W', 'L257Y', 'E258P', 'G262I', 'L265D', 'L265E', 'L265G', 'L265N', 'G266F', 'G266H', 'G266I', 'G266K', 'G266L', 'G266M', 'G266N', 'G266P', 'G266Q', 'G266T', 'G266V', 'G266W', 'G266Y', 'F270D', 'F270E', 'F270K', 'F270N', 'F270P', 'F270R', 'V272D', 'V272H', 'V272K', 'V272R', 'V272W', 'R273P', 'V274D', 'V274W', 'C275A', 'C275D', 'C275E', 'C275F', 'C275G', 'C275H', 'C275I', 'C275K', 'C275L', 'C275M', 'C275N', 'C275P', 'C275Q', 'C275R', 'C275T', 'C275V', 'C275W', 'C275Y', 'C277P', 'P278D', 'P278N', 'P278W', 'G279Y', 'D281P', 'R282D'] +- We aggregated all the variants that have at least one of the MAVISp modules with a predicted damaging effect (except for PTM.function) and retained only the ones with a Demask delta fitness >= 0.25 or <= -0.25 for a total of 1219 variants which could be of interest for further investigation: +-- ['S94P', 'P98A', 'P98E', 'P98F', 'P98G', 'P98H', 'P98I', 'P98K', 'P98L', 'P98M', 'P98Q', 'P98R', 'P98S', 'P98V', 'P98W', 'P98Y', 'S99D', 'S99H', 'S99K', 'S99L', 'S99M', 'S99P', 'S99R', 'S99W', 'Y103A', 'Y103C', 'Y103D', 'Y103E', 'Y103G', 'Y103H', 'Y103I', 'Y103K', 'Y103L', 'Y103M', 'Y103N', 'Y103P', 'Y103Q', 'Y103R', 'Y103S', 'Y103T', 'Y103V', 'Y103W', 'G105C', 'G105D', 'G105E', 'G105F', 'G105H', 'G105I', 'G105K', 'G105L', 'G105M', 'G105N', 'G105P', 'G105Q', 'G105R', 'G105S', 'G105T', 'G105V', 'G105W', 'G105Y', 'Y107A', 'Y107D', 'Y107E', 'Y107G', 'Y107I', 'Y107K', 'Y107M', 'Y107N', 'Y107P', 'Y107Q', 'Y107R', 'Y107S', 'Y107T', 'Y107V', 'G108F', 'G108I', 'G108P', 'G108W', 'G108Y', 'F109A', 'F109C', 'F109D', 'F109E', 'F109G', 'F109H', 'F109I', 'F109K', 'F109N', 'F109P', 'F109Q', 'F109R', 'F109S', 'F109T', 'F109V', 'F109W', 'R110P', 'L111A', 'L111C', 'L111D', 'L111E', 'L111F', 'L111G', 'L111H', 'L111K', 'L111N', 'L111P', 'L111Q', 'L111R', 'L111S', 'L111T', 'L111W', 'L111Y', 'G112P', 'F113A', 'F113C', 'F113D', 'F113E', 'F113G', 'F113H', 'F113I', 'F113K', 'F113L', 'F113M', 'F113N', 'F113P', 'F113Q', 'F113R', 'F113S', 'F113T', 'F113V', 'F113W', 'H115P', 'S116P', 'G117P', 'S121P', 'V122F', 'V122H', 'V122P', 'V122W', 'V122Y', 'C124E', 'C124F', 'C124H', 'C124K', 'C124P', 'C124Q', 'C124R', 'C124Y', 'T125A', 'T125C', 'T125F', 'T125G', 'T125H', 'T125K', 'T125P', 'T125R', 'T125S', 'T125W', 'T125Y', 'Y126A', 'Y126C', 'Y126D', 'Y126E', 'Y126G', 'Y126H', 'Y126K', 'Y126N', 'Y126P', 'Y126Q', 'Y126R', 'Y126S', 'Y126T', 'S127D', 'S127E', 'S127F', 'S127G', 'S127H', 'S127K', 'S127L', 'S127M', 'S127P', 'S127Q', 'S127R', 'S127V', 'S127W', 'S127Y', 'L130P', 'N131P', 'K132D', 'K132P', 'M133D', 'M133E', 'M133F', 'M133G', 'M133H', 'M133K', 'M133N', 'M133P', 'M133Q', 'M133R', 'M133S', 'M133T', 'M133W', 'M133Y', 'F134A', 'F134C', 'F134D', 'F134E', 'F134G', 'F134K', 'F134N', 'F134P', 'F134Q', 'F134R', 'F134S', 'F134T', 'C135D', 'C135E', 'C135F', 'C135H', 'C135K', 'C135P', 'C135Q', 'C135R', 'C135W', 'C135Y', 'Q136A', 'Q136C', 'Q136D', 'Q136E', 'Q136F', 'Q136G', 'Q136H', 'Q136I', 'Q136K', 'Q136L', 'Q136M', 'Q136N', 'Q136P', 'Q136S', 'Q136T', 'Q136W', 'Q136Y', 'A138C', 'A138D', 'A138E', 'A138F', 'A138H', 'A138I', 'A138K', 'A138L', 'A138M', 'A138N', 'A138P', 'A138Q', 'A138R', 'A138T', 'A138V', 'A138W', 'A138Y', 'K139P', 'C141E', 'C141F', 'C141G', 'C141H', 'C141K', 'C141P', 'C141R', 'C141W', 'C141Y', 'P142D', 'P142H', 'V143A', 'V143D', 'V143E', 'V143G', 'V143H', 'V143K', 'V143N', 'V143P', 'V143Q', 'V143R', 'V143S', 'V143T', 'V143W', 'V143Y', 'Q144P', 'L145A', 'L145C', 'L145D', 'L145E', 'L145G', 'L145H', 'L145K', 'L145N', 'L145P', 'L145Q', 'L145R', 'L145S', 'L145W', 'L145Y', 'W146D', 'W146P', 'V147D', 'V147E', 'V147F', 'V147G', 'V147H', 'V147K', 'V147N', 'V147P', 'V147Q', 'V147R', 'V147W', 'V147Y', 'P151A', 'P151D', 'P151E', 'P151F', 'P151G', 'P151H', 'P151I', 'P151K', 'P151L', 'P151M', 'P151N', 'P151Q', 'P151R', 'P151W', 'P151Y', 'P152W', 'G154I', 'G154P', 'G154T', 'G154V', 'T155D', 'T155E', 'T155F', 'T155H', 'T155K', 'T155L', 'T155P', 'T155Q', 'T155R', 'T155W', 'T155Y', 'R156D', 'R156P', 'V157D', 'V157E', 'V157G', 'V157H', 'V157K', 'V157N', 'V157P', 'V157Q', 'V157R', 'V157S', 'V157W', 'V157Y', 'R158A', 'R158C', 'R158D', 'R158E', 'R158F', 'R158G', 'R158H', 'R158I', 'R158L', 'R158M', 'R158N', 'R158P', 'R158Q', 'R158S', 'R158T', 'R158V', 'R158W', 'R158Y', 'A159D', 'A159F', 'A159H', 'A159I', 'A159K', 'A159P', 'A159R', 'A159W', 'A159Y', 'M160A', 'M160C', 'M160D', 'M160E', 'M160F', 'M160G', 'M160H', 'M160K', 'M160N', 'M160P', 'M160Q', 'M160R', 'M160S', 'M160W', 'M160Y', 'A161D', 'A161E', 'A161F', 'A161H', 'A161K', 'A161N', 'A161R', 'A161W', 'A161Y', 'I162D', 'I162E', 'I162F', 'I162G', 'I162H', 'I162K', 'I162N', 'I162P', 'I162R', 'I162W', 'I162Y', 'Y163A', 'Y163C', 'Y163D', 'Y163E', 'Y163G', 'Y163K', 'Y163N', 'Y163P', 'Y163Q', 'Y163R', 'Y163S', 'Y163T', 'K164P', 'Q165A', 'Q165C', 'Q165D', 'Q165G', 'Q165P', 'Q165T', 'Q167P', 'H168A', 'H168C', 'H168E', 'H168G', 'H168I', 'H168K', 'H168L', 'H168M', 'H168N', 'H168P', 'H168R', 'H168S', 'H168T', 'H168V', 'H168W', 'M169P', 'E171P', 'V172F', 'V172H', 'V172P', 'V172R', 'V172W', 'V172Y', 'V173A', 'V173C', 'V173D', 'V173E', 'V173F', 'V173G', 'V173H', 'V173K', 'V173M', 'V173N', 'V173P', 'V173Q', 'V173R', 'V173S', 'V173T', 'V173W', 'V173Y', 'R174D', 'R174E', 'R174P', 'R175A', 'R175C', 'R175D', 'R175E', 'R175F', 'R175G', 'R175H', 'R175I', 'R175L', 'R175M', 'R175N', 'R175P', 'R175Q', 'R175S', 'R175T', 'R175V', 'R175W', 'R175Y', 'C176F', 'C176H', 'C176I', 'C176K', 'C176L', 'C176M', 'C176N', 'C176P', 'C176Q', 'C176R', 'C176V', 'C176W', 'C176Y', 'H178P', 'H179A', 'H179C', 'H179D', 'H179E', 'H179F', 'H179G', 'H179I', 'H179K', 'H179L', 'H179M', 'H179N', 'H179P', 'H179R', 'H179S', 'H179T', 'H179V', 'H179W', 'H179Y', 'E180P', 'R181P', 'C182P', 'D186F', 'D186I', 'D186K', 'D186L', 'D186P', 'D186R', 'D186V', 'D186W', 'G187P', 'A189F', 'A189G', 'A189H', 'A189K', 'A189P', 'A189R', 'A189W', 'A189Y', 'P190E', 'P190F', 'P190G', 'P190I', 'P190K', 'P190L', 'P190M', 'P190R', 'P190V', 'P190W', 'P190Y', 'Q192P', 'H193A', 'H193C', 'H193D', 'H193E', 'H193F', 'H193G', 'H193I', 'H193K', 'H193L', 'H193M', 'H193N', 'H193P', 'H193Q', 'H193R', 'H193S', 'H193T', 'H193V', 'H193W', 'H193Y', 'L194D', 'L194F', 'L194G', 'L194H', 'L194K', 'L194N', 'L194P', 'L194R', 'L194S', 'L194W', 'L194Y', 'I195A', 'I195D', 'I195E', 'I195F', 'I195G', 'I195H', 'I195K', 'I195N', 'I195P', 'I195Q', 'I195R', 'I195S', 'I195T', 'I195W', 'I195Y', 'R196A', 'R196C', 'R196D', 'R196E', 'R196F', 'R196G', 'R196H', 'R196I', 'R196L', 'R196M', 'R196N', 'R196P', 'R196Q', 'R196S', 'R196T', 'R196V', 'R196W', 'R196Y', 'V197A', 'V197C', 'V197D', 'V197E', 'V197F', 'V197G', 'V197H', 'V197K', 'V197N', 'V197P', 'V197Q', 'V197R', 'V197S', 'V197T', 'V197W', 'V197Y', 'E198A', 'E198C', 'E198D', 'E198F', 'E198G', 'E198H', 'E198I', 'E198K', 'E198L', 'E198M', 'E198N', 'E198P', 'E198Q', 'E198R', 'E198S', 'E198T', 'E198W', 'E198Y', 'G199I', 'G199P', 'G199T', 'G199V', 'N200A', 'N200C', 'N200E', 'N200F', 'N200H', 'N200K', 'N200L', 'N200M', 'N200P', 'N200Q', 'N200R', 'N200V', 'N200W', 'N200Y', 'V203D', 'V203E', 'V203F', 'V203G', 'V203H', 'V203K', 'V203M', 'V203N', 'V203P', 'V203Q', 'V203R', 'V203S', 'V203T', 'V203W', 'V203Y', 'E204P', 'Y205A', 'Y205C', 'Y205D', 'Y205E', 'Y205G', 'Y205H', 'Y205I', 'Y205K', 'Y205L', 'Y205M', 'Y205N', 'Y205P', 'Y205Q', 'Y205R', 'Y205S', 'Y205T', 'Y205V', 'Y205W', 'D208G', 'D208I', 'D208P', 'D208Y', 'T211C', 'T211D', 'T211E', 'T211F', 'T211G', 'T211H', 'T211I', 'T211K', 'T211L', 'T211M', 'T211N', 'T211P', 'T211Q', 'T211R', 'T211V', 'T211W', 'F212P', 'R213P', 'S215A', 'S215C', 'S215E', 'S215G', 'S215H', 'S215I', 'S215K', 'S215L', 'S215N', 'S215P', 'S215Q', 'S215T', 'S215V', 'S215W', 'S215Y', 'V216A', 'V216C', 'V216D', 'V216E', 'V216F', 'V216G', 'V216H', 'V216K', 'V216M', 'V216N', 'V216P', 'V216Q', 'V216R', 'V216S', 'V216T', 'V216W', 'V216Y', 'V217D', 'V217N', 'V217P', 'V218A', 'V218C', 'V218D', 'V218E', 'V218F', 'V218G', 'V218H', 'V218K', 'V218N', 'V218P', 'V218Q', 'V218R', 'V218S', 'V218T', 'V218W', 'V218Y', 'Y220A', 'Y220C', 'Y220D', 'Y220E', 'Y220G', 'Y220H', 'Y220I', 'Y220K', 'Y220L', 'Y220M', 'Y220N', 'Y220P', 'Y220Q', 'Y220R', 'Y220S', 'Y220T', 'Y220V', 'Y220W', 'P222F', 'P222W', 'P223E', 'P223F', 'P223H', 'P223I', 'P223K', 'P223Q', 'P223R', 'P223W', 'P223Y', 'G226I', 'G226P', 'G226T', 'G226V', 'C229P', 'T230H', 'T230P', 'T230W', 'T230Y', 'I232A', 'I232C', 'I232D', 'I232E', 'I232G', 'I232H', 'I232K', 'I232N', 'I232P', 'I232Q', 'I232R', 'I232S', 'I232W', 'I232Y', 'H233P', 'Y234A', 'Y234C', 'Y234D', 'Y234E', 'Y234G', 'Y234H', 'Y234I', 'Y234K', 'Y234L', 'Y234M', 'Y234N', 'Y234P', 'Y234Q', 'Y234R', 'Y234S', 'Y234T', 'Y234V', 'Y234W', 'N235P', 'Y236A', 'Y236C', 'Y236D', 'Y236E', 'Y236G', 'Y236H', 'Y236I', 'Y236K', 'Y236L', 'Y236M', 'Y236N', 'Y236P', 'Y236Q', 'Y236R', 'Y236S', 'Y236T', 'Y236V', 'Y236W', 'M237A', 'M237C', 'M237D', 'M237E', 'M237F', 'M237G', 'M237H', 'M237K', 'M237N', 'M237P', 'M237Q', 'M237R', 'M237S', 'M237T', 'M237V', 'M237W', 'M237Y', 'C238F', 'C238H', 'C238K', 'C238P', 'C238R', 'C238W', 'C238Y', 'S240H', 'S240P', 'S240W', 'S240Y', 'S241P', 'C242F', 'C242H', 'C242I', 'C242K', 'C242L', 'C242M', 'C242N', 'C242P', 'C242Q', 'C242R', 'C242T', 'C242V', 'C242W', 'C242Y', 'G244C', 'G244I', 'G244P', 'G244T', 'G244V', 'G245C', 'G245D', 'G245E', 'G245F', 'G245H', 'G245I', 'G245K', 'G245L', 'G245M', 'G245N', 'G245P', 'G245Q', 'G245R', 'G245S', 'G245T', 'G245V', 'G245W', 'G245Y', 'M246G', 'M246H', 'M246K', 'M246R', 'M246S', 'M246W', 'M246Y', 'N247I', 'N247P', 'R248P', 'R249A', 'R249C', 'R249D', 'R249E', 'R249F', 'R249G', 'R249H', 'R249I', 'R249K', 'R249L', 'R249M', 'R249N', 'R249P', 'R249Q', 'R249S', 'R249T', 'R249V', 'R249W', 'R249Y', 'I251A', 'I251C', 'I251D', 'I251E', 'I251F', 'I251G', 'I251H', 'I251K', 'I251N', 'I251P', 'I251Q', 'I251R', 'I251S', 'I251T', 'I251W', 'I251Y', 'L252D', 'L252E', 'L252G', 'L252H', 'L252N', 'L252P', 'L252S', 'T253D', 'T253G', 'T253K', 'T253P', 'T253R', 'T253W', 'T253Y', 'I254A', 'I254D', 'I254E', 'I254F', 'I254G', 'I254H', 'I254K', 'I254N', 'I254P', 'I254Q', 'I254R', 'I254S', 'I254W', 'I254Y', 'I255A', 'I255C', 'I255D', 'I255E', 'I255G', 'I255H', 'I255K', 'I255N', 'I255P', 'I255Q', 'I255R', 'I255S', 'I255W', 'I255Y', 'T256P', 'L257A', 'L257C', 'L257D', 'L257E', 'L257F', 'L257G', 'L257H', 'L257K', 'L257N', 'L257P', 'L257Q', 'L257R', 'L257S', 'L257T', 'L257W', 'L257Y', 'E258D', 'E258P', 'D259F', 'D259I', 'D259K', 'D259L', 'D259P', 'D259Q', 'D259R', 'D259V', 'D259W', 'S261P', 'G262I', 'G262P', 'G262T', 'G262V', 'N263P', 'L264G', 'L265A', 'L265D', 'L265E', 'L265G', 'L265H', 'L265K', 'L265N', 'L265P', 'L265Q', 'L265R', 'L265S', 'L265T', 'G266C', 'G266D', 'G266E', 'G266F', 'G266H', 'G266I', 'G266K', 'G266L', 'G266M', 'G266N', 'G266P', 'G266Q', 'G266R', 'G266S', 'G266T', 'G266V', 'G266W', 'G266Y', 'R267D', 'R267G', 'R267P', 'R267W', 'R267Y', 'N268P', 'F270A', 'F270C', 'F270D', 'F270E', 'F270G', 'F270H', 'F270I', 'F270K', 'F270L', 'F270M', 'F270N', 'F270P', 'F270Q', 'F270R', 'F270S', 'F270T', 'F270V', 'F270W', 'V272D', 'V272E', 'V272F', 'V272H', 'V272K', 'V272N', 'V272P', 'V272Q', 'V272R', 'V272S', 'V272W', 'V272Y', 'R273P', 'V274D', 'V274E', 'V274F', 'V274G', 'V274H', 'V274K', 'V274N', 'V274P', 'V274Q', 'V274R', 'V274S', 'V274W', 'V274Y', 'C275A', 'C275D', 'C275E', 'C275F', 'C275G', 'C275H', 'C275I', 'C275K', 'C275L', 'C275M', 'C275N', 'C275P', 'C275Q', 'C275R', 'C275S', 'C275T', 'C275V', 'C275W', 'C275Y', 'C277P', 'P278D', 'P278E', 'P278F', 'P278H', 'P278I', 'P278K', 'P278L', 'P278M', 'P278N', 'P278Q', 'P278R', 'P278S', 'P278T', 'P278V', 'P278W', 'P278Y', 'G279C', 'G279D', 'G279E', 'G279F', 'G279H', 'G279I', 'G279K', 'G279L', 'G279M', 'G279N', 'G279P', 'G279Q', 'G279R', 'G279S', 'G279T', 'G279V', 'G279W', 'G279Y', 'R280P', 'D281G', 'D281P', 'R282D', 'R282P', 'R283P', 'T284D', 'T284E', 'T284F', 'T284G', 'T284K', 'T284P', 'T284R', 'T284W', 'E285P', 'E286P', 'E287P', 'N288P'] +- We aggregated all the variants that have at least one of the MAVISp modules with a predicted damaging effect (except for PTM.function) and retained only the ones with an EVE classification of Pathogenic for a total of 837 variants which could be of interest for further investigation: + -- ['S94W', 'P98A', 'P98E', 'P98F', 'P98G', 'P98K', 'P98M', 'P98R', 'P98W', 'P98Y', 'S99H', 'S99Q', 'S99W', 'Y103A', 'Y103E', 'Y103G', 'Y103K', 'Y103P', 'Y103Q', 'Y103R', 'Y103T', 'G105E', 'G105F', 'G105H', 'G105I', 'G105K', 'G105L', 'G105M', 'G105P', 'G105Q', 'G105R', 'G105T', 'G105V', 'G105W', 'G105Y', 'Y107E', 'Y107G', 'Y107K', 'Y107T', 'F109A', 'F109C', 'F109D', 'F109E', 'F109G', 'F109H', 'F109I', 'F109K', 'F109N', 'F109P', 'F109Q', 'F109R', 'F109S', 'F109T', 'F109V', 'F109W', 'L111A', 'L111D', 'L111E', 'L111G', 'L111H', 'L111K', 'L111N', 'L111P', 'L111Q', 'L111R', 'L111S', 'L111T', 'L111W', 'F113A', 'F113D', 'F113E', 'F113G', 'F113H', 'F113K', 'F113N', 'F113P', 'F113Q', 'F113R', 'F113S', 'F113T', 'S121P', 'V122F', 'V122H', 'V122W', 'V122Y', 'C124E', 'C124K', 'C124P', 'C124Q', 'C124R', 'T125C', 'T125F', 'T125H', 'T125P', 'T125R', 'T125W', 'T125Y', 'Y126A', 'Y126C', 'Y126D', 'Y126E', 'Y126G', 'Y126K', 'Y126N', 'Y126P', 'Y126Q', 'Y126R', 'Y126S', 'Y126T', 'S127E', 'S127F', 'S127G', 'S127H', 'S127K', 'S127L', 'S127M', 'S127P', 'S127Q', 'S127R', 'S127W', 'S127Y', 'L130P', 'N131I', 'N131P', 'K132D', 'K132P', 'F134A', 'F134C', 'F134D', 'F134E', 'F134G', 'F134K', 'F134N', 'F134P', 'F134Q', 'F134R', 'F134S', 'F134T', 'C135D', 'C135E', 'C135F', 'C135H', 'C135K', 'C135P', 'C135Q', 'C135R', 'C135W', 'C135Y', 'Q136A', 'Q136C', 'Q136F', 'Q136G', 'Q136H', 'Q136I', 'Q136P', 'Q136S', 'Q136T', 'Q136W', 'Q136Y', 'A138H', 'A138I', 'A138L', 'A138P', 'A138W', 'A138Y', 'K139P', 'C141E', 'C141G', 'C141H', 'C141K', 'C141P', 'C141R', 'C141W', 'C141Y', 'P142D', 'V143D', 'V143E', 'V143G', 'V143H', 'V143K', 'V143N', 'V143P', 'V143Q', 'V143R', 'V143S', 'V143T', 'V143W', 'V143Y', 'Q144P', 'L145E', 'L145G', 'L145Q', 'L145W', 'V147D', 'V147E', 'V147G', 'V147H', 'V147K', 'V147N', 'V147P', 'V147Q', 'V147R', 'P151G', 'P151H', 'P151N', 'P151R', 'P151W', 'P152W', 'G154I', 'T155W', 'V157A', 'V157D', 'V157E', 'V157F', 'V157G', 'V157H', 'V157K', 'V157N', 'V157P', 'V157Q', 'V157R', 'V157S', 'V157T', 'V157W', 'V157Y', 'R158A', 'R158D', 'R158E', 'R158F', 'R158G', 'R158I', 'R158M', 'R158N', 'R158P', 'R158Q', 'R158T', 'R158W', 'R158Y', 'A159D', 'A159F', 'A159K', 'A159P', 'A159R', 'A159W', 'A159Y', 'M160C', 'M160D', 'M160F', 'M160H', 'M160N', 'M160P', 'M160R', 'M160W', 'A161D', 'A161E', 'A161F', 'A161H', 'A161K', 'A161N', 'A161R', 'A161W', 'A161Y', 'I162D', 'I162E', 'I162H', 'I162N', 'I162P', 'I162R', 'I162W', 'I162Y', 'Y163A', 'Y163D', 'Y163E', 'Y163G', 'Y163K', 'Y163N', 'Y163P', 'Y163Q', 'Y163R', 'Y163S', 'Y163T', 'K164P', 'H168C', 'H168E', 'H168G', 'H168I', 'H168K', 'H168L', 'H168M', 'H168P', 'H168R', 'H168T', 'H168V', 'H168W', 'E171P', 'V172F', 'V172R', 'V172W', 'V172Y', 'V173C', 'V173D', 'V173E', 'V173F', 'V173G', 'V173H', 'V173K', 'V173M', 'V173N', 'V173P', 'V173Q', 'V173R', 'V173S', 'V173T', 'V173W', 'V173Y', 'R175A', 'R175D', 'R175F', 'R175G', 'R175L', 'R175N', 'R175W', 'R175Y', 'C176F', 'C176I', 'C176K', 'C176L', 'C176M', 'C176N', 'C176P', 'C176Q', 'C176R', 'C176V', 'C176W', 'C176Y', 'H178P', 'H179A', 'H179C', 'H179D', 'H179E', 'H179F', 'H179G', 'H179I', 'H179K', 'H179M', 'H179P', 'H179Q', 'H179R', 'H179S', 'H179T', 'H179V', 'H179W', 'H179Y', 'E180P', 'R181P', 'D186F', 'D186G', 'D186I', 'D186M', 'D186V', 'D186W', 'D186Y', 'A189R', 'A189W', 'P190G', 'P190M', 'P190W', 'Q192W', 'H193A', 'H193C', 'H193D', 'H193E', 'H193F', 'H193G', 'H193I', 'H193K', 'H193L', 'H193M', 'H193N', 'H193P', 'H193R', 'H193S', 'H193T', 'H193V', 'H193W', 'L194D', 'L194G', 'L194H', 'L194K', 'L194N', 'L194P', 'L194R', 'L194S', 'L194Y', 'I195A', 'I195D', 'I195E', 'I195G', 'I195H', 'I195K', 'I195N', 'I195P', 'I195Q', 'I195R', 'I195S', 'I195T', 'I195W', 'I195Y', 'R196A', 'R196D', 'R196E', 'R196F', 'R196G', 'R196I', 'R196M', 'R196N', 'R196P', 'R196V', 'V197D', 'V197E', 'V197F', 'V197G', 'V197H', 'V197K', 'V197N', 'V197P', 'V197Q', 'V197R', 'V197W', 'V197Y', 'E198C', 'E198F', 'E198I', 'E198M', 'E198W', 'E198Y', 'G199I', 'G199P', 'G199T', 'G199V', 'N200A', 'N200Q', 'N200Y', 'Y205A', 'Y205D', 'Y205E', 'Y205G', 'Y205K', 'Y205L', 'Y205M', 'Y205N', 'Y205P', 'Y205Q', 'Y205R', 'Y205S', 'Y205T', 'Y205V', 'Y205W', 'D208I', 'D208P', 'D208Y', 'T211C', 'T211F', 'T211H', 'T211L', 'T211M', 'T211P', 'T211R', 'T211V', 'T211W', 'R213P', 'S215A', 'S215E', 'S215G', 'S215H', 'S215I', 'S215K', 'S215L', 'S215M', 'S215P', 'S215Q', 'S215V', 'S215W', 'S215Y', 'V216D', 'V216E', 'V216F', 'V216G', 'V216H', 'V216K', 'V216M', 'V216N', 'V216P', 'V216Q', 'V216R', 'V216S', 'V216T', 'V216W', 'V216Y', 'V218D', 'V218E', 'V218H', 'V218K', 'V218N', 'V218P', 'V218Q', 'V218R', 'V218W', 'Y220A', 'Y220C', 'Y220D', 'Y220E', 'Y220G', 'Y220K', 'Y220N', 'Y220P', 'Y220R', 'Y220S', 'Y220W', 'P223E', 'P223F', 'P223H', 'P223I', 'P223K', 'P223R', 'P223W', 'P223Y', 'G226I', 'G226P', 'G226T', 'G226V', 'T230H', 'T230P', 'T230W', 'I232K', 'I232P', 'I232Q', 'I232W', 'Y234A', 'Y234C', 'Y234D', 'Y234E', 'Y234G', 'Y234H', 'Y234K', 'Y234M', 'Y234N', 'Y234P', 'Y234Q', 'Y234S', 'Y234V', 'Y234W', 'N235P', 'Y236N', 'Y236Q', 'Y236R', 'Y236W', 'M237C', 'M237D', 'M237E', 'M237H', 'M237N', 'M237Q', 'M237R', 'M237W', 'C238F', 'C238H', 'C238K', 'C238P', 'C238R', 'C238W', 'C238Y', 'S240H', 'S240P', 'S240W', 'S240Y', 'S241P', 'C242F', 'C242H', 'C242I', 'C242K', 'C242L', 'C242M', 'C242N', 'C242P', 'C242Q', 'C242R', 'C242T', 'C242V', 'C242W', 'C242Y', 'G244C', 'G244I', 'G244V', 'G245C', 'G245D', 'G245E', 'G245F', 'G245H', 'G245I', 'G245K', 'G245L', 'G245M', 'G245N', 'G245P', 'G245Q', 'G245V', 'G245W', 'G245Y', 'M246G', 'M246K', 'M246R', 'M246S', 'M246W', 'M246Y', 'N247I', 'N247P', 'R248P', 'R249A', 'R249C', 'R249D', 'R249F', 'R249G', 'R249H', 'R249I', 'R249L', 'R249N', 'R249P', 'R249T', 'R249V', 'R249W', 'R249Y', 'I251A', 'I251C', 'I251D', 'I251E', 'I251F', 'I251G', 'I251H', 'I251K', 'I251N', 'I251P', 'I251Q', 'I251R', 'I251S', 'I251W', 'I251Y', 'L252P', 'T253D', 'T253G', 'T253K', 'T253P', 'T253R', 'T253W', 'T253Y', 'I254A', 'I254D', 'I254E', 'I254F', 'I254G', 'I254H', 'I254K', 'I254N', 'I254P', 'I254Q', 'I254R', 'I254S', 'I254W', 'I254Y', 'I255A', 'I255C', 'I255D', 'I255E', 'I255G', 'I255H', 'I255K', 'I255N', 'I255P', 'I255Q', 'I255R', 'I255S', 'I255T', 'L257A', 'L257C', 'L257D', 'L257E', 'L257F', 'L257G', 'L257H', 'L257K', 'L257N', 'L257P', 'L257Q', 'L257R', 'L257S', 'L257T', 'L257W', 'L257Y', 'E258D', 'E258P', 'D259W', 'G262I', 'G262P', 'G262V', 'L264G', 'L265A', 'L265D', 'L265E', 'L265G', 'L265K', 'L265N', 'L265P', 'L265Q', 'L265R', 'L265S', 'L265T', 'G266C', 'G266D', 'G266E', 'G266F', 'G266H', 'G266I', 'G266K', 'G266L', 'G266M', 'G266N', 'G266P', 'G266Q', 'G266R', 'G266S', 'G266T', 'G266V', 'G266W', 'G266Y', 'R267D', 'R267G', 'R267P', 'R267W', 'R267Y', 'F270A', 'F270C', 'F270D', 'F270E', 'F270G', 'F270H', 'F270K', 'F270N', 'F270P', 'F270Q', 'F270R', 'F270S', 'F270T', 'F270W', 'V272D', 'V272E', 'V272F', 'V272H', 'V272K', 'V272N', 'V272P', 'V272Q', 'V272R', 'V272S', 'V272W', 'V272Y', 'R273P', 'V274D', 'V274E', 'V274F', 'V274G', 'V274H', 'V274K', 'V274N', 'V274Q', 'V274R', 'V274W', 'V274Y', 'C275A', 'C275D', 'C275E', 'C275F', 'C275G', 'C275H', 'C275I', 'C275K', 'C275L', 'C275M', 'C275N', 'C275P', 'C275Q', 'C275R', 'C275S', 'C275T', 'C275V', 'C275W', 'C275Y', 'C277P', 'P278D', 'P278E', 'P278F', 'P278H', 'P278I', 'P278K', 'P278M', 'P278N', 'P278Q', 'P278R', 'P278T', 'P278V', 'P278W', 'P278Y', 'G279C', 'G279D', 'G279E', 'G279F', 'G279I', 'G279M', 'G279N', 'G279P', 'G279Q', 'G279V', 'G279W', 'G279Y', 'R280P', 'D281G', 'D281P', 'R282D', 'R282P', 'R283P', 'T284C', 'T284D', 'T284F', 'T284P', 'T284W', 'E285P', 'E286P', 'N288P'] +- We aggregated all the variants that have at least one of the MAVISp modules with a predicted damaging effect (except for PTM.function) and retained only the ones with an AlphaMissense classification of Pathogenic for a total of 1272 variants which could be of interest for further investigation: + -- ['S94F', 'S94H', 'S94R', 'S94W', 'S94Y', 'P98A', 'P98E', 'P98F', 'P98G', 'P98H', 'P98I', 'P98K', 'P98L', 'P98M', 'P98Q', 'P98R', 'P98S', 'P98V', 'P98W', 'P98Y', 'S99D', 'S99E', 'S99F', 'S99H', 'S99I', 'S99K', 'S99M', 'S99N', 'S99Q', 'S99R', 'S99W', 'Y103A', 'Y103D', 'Y103E', 'Y103G', 'Y103I', 'Y103K', 'Y103L', 'Y103M', 'Y103N', 'Y103P', 'Y103Q', 'Y103R', 'Y103S', 'Y103T', 'Y103V', 'G105C', 'G105D', 'G105E', 'G105F', 'G105H', 'G105I', 'G105K', 'G105L', 'G105M', 'G105N', 'G105P', 'G105Q', 'G105R', 'G105S', 'G105T', 'G105V', 'G105W', 'G105Y', 'Y107A', 'Y107D', 'Y107E', 'Y107G', 'Y107I', 'Y107K', 'Y107M', 'Y107P', 'Y107Q', 'Y107R', 'Y107T', 'G108F', 'G108I', 'G108L', 'G108M', 'G108P', 'G108V', 'G108W', 'G108Y', 'F109A', 'F109C', 'F109D', 'F109E', 'F109G', 'F109H', 'F109I', 'F109K', 'F109N', 'F109P', 'F109Q', 'F109R', 'F109S', 'F109T', 'F109V', 'F109W', 'R110P', 'L111A', 'L111C', 'L111D', 'L111E', 'L111F', 'L111G', 'L111H', 'L111K', 'L111N', 'L111P', 'L111Q', 'L111R', 'L111S', 'L111T', 'L111W', 'L111Y', 'G112P', 'F113A', 'F113C', 'F113D', 'F113E', 'F113G', 'F113H', 'F113I', 'F113K', 'F113L', 'F113M', 'F113N', 'F113P', 'F113Q', 'F113R', 'F113S', 'F113T', 'F113V', 'F113W', 'S116P', 'G117P', 'S121P', 'V122F', 'V122H', 'V122P', 'V122W', 'V122Y', 'C124E', 'C124H', 'C124K', 'C124P', 'C124Q', 'C124R', 'C124W', 'C124Y', 'T125A', 'T125C', 'T125F', 'T125G', 'T125H', 'T125K', 'T125P', 'T125R', 'T125S', 'T125W', 'T125Y', 'Y126A', 'Y126C', 'Y126D', 'Y126E', 'Y126G', 'Y126H', 'Y126K', 'Y126N', 'Y126P', 'Y126Q', 'Y126R', 'Y126S', 'Y126T', 'S127D', 'S127E', 'S127F', 'S127G', 'S127H', 'S127K', 'S127L', 'S127M', 'S127P', 'S127Q', 'S127R', 'S127V', 'S127W', 'S127Y', 'L130P', 'N131I', 'N131P', 'K132D', 'K132P', 'M133D', 'M133E', 'M133F', 'M133G', 'M133H', 'M133K', 'M133N', 'M133P', 'M133Q', 'M133R', 'M133S', 'M133T', 'M133W', 'M133Y', 'F134A', 'F134C', 'F134D', 'F134E', 'F134G', 'F134K', 'F134N', 'F134P', 'F134Q', 'F134R', 'F134S', 'F134T', 'C135D', 'C135E', 'C135F', 'C135H', 'C135K', 'C135P', 'C135Q', 'C135R', 'C135W', 'C135Y', 'Q136A', 'Q136C', 'Q136D', 'Q136E', 'Q136F', 'Q136G', 'Q136H', 'Q136I', 'Q136K', 'Q136L', 'Q136M', 'Q136N', 'Q136P', 'Q136R', 'Q136S', 'Q136T', 'Q136W', 'Q136Y', 'A138C', 'A138D', 'A138E', 'A138F', 'A138H', 'A138I', 'A138K', 'A138L', 'A138M', 'A138N', 'A138P', 'A138Q', 'A138R', 'A138T', 'A138V', 'A138W', 'A138Y', 'K139P', 'C141E', 'C141F', 'C141G', 'C141H', 'C141K', 'C141P', 'C141R', 'C141W', 'C141Y', 'P142D', 'P142H', 'V143A', 'V143D', 'V143E', 'V143G', 'V143H', 'V143K', 'V143N', 'V143P', 'V143Q', 'V143R', 'V143S', 'V143T', 'V143W', 'V143Y', 'Q144P', 'L145A', 'L145C', 'L145D', 'L145E', 'L145G', 'L145H', 'L145K', 'L145N', 'L145P', 'L145Q', 'L145R', 'L145S', 'L145T', 'L145W', 'L145Y', 'W146D', 'W146P', 'V147D', 'V147E', 'V147F', 'V147G', 'V147H', 'V147K', 'V147N', 'V147P', 'V147Q', 'V147R', 'V147W', 'V147Y', 'D148P', 'S149P', 'P151A', 'P151D', 'P151E', 'P151F', 'P151G', 'P151H', 'P151I', 'P151K', 'P151M', 'P151N', 'P151Q', 'P151R', 'P151S', 'P151V', 'P151W', 'P151Y', 'P152W', 'G154I', 'G154P', 'G154V', 'T155D', 'T155E', 'T155F', 'T155H', 'T155I', 'T155K', 'T155L', 'T155N', 'T155P', 'T155Q', 'T155R', 'T155W', 'T155Y', 'R156D', 'R156P', 'V157A', 'V157D', 'V157E', 'V157F', 'V157G', 'V157H', 'V157K', 'V157N', 'V157P', 'V157Q', 'V157R', 'V157S', 'V157T', 'V157W', 'V157Y', 'R158A', 'R158C', 'R158D', 'R158E', 'R158F', 'R158G', 'R158H', 'R158I', 'R158L', 'R158M', 'R158N', 'R158P', 'R158Q', 'R158S', 'R158T', 'R158V', 'R158W', 'R158Y', 'A159D', 'A159F', 'A159H', 'A159I', 'A159K', 'A159P', 'A159R', 'A159W', 'A159Y', 'M160A', 'M160C', 'M160D', 'M160E', 'M160F', 'M160G', 'M160H', 'M160K', 'M160N', 'M160P', 'M160Q', 'M160R', 'M160S', 'M160W', 'M160Y', 'A161D', 'A161E', 'A161F', 'A161H', 'A161K', 'A161N', 'A161R', 'A161W', 'A161Y', 'I162D', 'I162E', 'I162F', 'I162G', 'I162H', 'I162K', 'I162N', 'I162P', 'I162R', 'I162W', 'I162Y', 'Y163A', 'Y163C', 'Y163D', 'Y163E', 'Y163G', 'Y163K', 'Y163N', 'Y163P', 'Y163Q', 'Y163R', 'Y163S', 'Y163T', 'K164P', 'Q165C', 'Q165D', 'Q165P', 'H168A', 'H168C', 'H168D', 'H168E', 'H168G', 'H168I', 'H168K', 'H168L', 'H168M', 'H168P', 'H168Q', 'H168R', 'H168S', 'H168T', 'H168V', 'H168W', 'M169P', 'E171P', 'V172F', 'V172H', 'V172P', 'V172R', 'V172W', 'V172Y', 'V173A', 'V173C', 'V173D', 'V173E', 'V173F', 'V173G', 'V173H', 'V173K', 'V173M', 'V173N', 'V173P', 'V173Q', 'V173R', 'V173S', 'V173T', 'V173W', 'V173Y', 'R174D', 'R174E', 'R174P', 'R175A', 'R175C', 'R175D', 'R175E', 'R175F', 'R175G', 'R175H', 'R175I', 'R175L', 'R175M', 'R175N', 'R175P', 'R175Q', 'R175S', 'R175T', 'R175V', 'R175W', 'R175Y', 'C176F', 'C176H', 'C176I', 'C176K', 'C176L', 'C176M', 'C176N', 'C176P', 'C176Q', 'C176R', 'C176V', 'C176W', 'C176Y', 'H178P', 'H179A', 'H179C', 'H179D', 'H179E', 'H179F', 'H179G', 'H179I', 'H179K', 'H179L', 'H179M', 'H179N', 'H179P', 'H179Q', 'H179R', 'H179S', 'H179T', 'H179V', 'H179W', 'H179Y', 'E180P', 'R181P', 'C182P', 'S183D', 'S183E', 'S183K', 'S183Q', 'S183R', 'S185E', 'S185K', 'S185R', 'D186A', 'D186F', 'D186H', 'D186I', 'D186K', 'D186L', 'D186M', 'D186P', 'D186Q', 'D186R', 'D186V', 'D186W', 'D186Y', 'G187P', 'A189F', 'A189G', 'A189H', 'A189K', 'A189P', 'A189R', 'A189W', 'A189Y', 'P190E', 'P190F', 'P190G', 'P190H', 'P190I', 'P190K', 'P190L', 'P190M', 'P190Q', 'P190R', 'P190S', 'P190V', 'P190W', 'P190Y', 'P191H', 'Q192C', 'Q192D', 'Q192F', 'Q192I', 'Q192M', 'Q192W', 'Q192Y', 'H193A', 'H193C', 'H193D', 'H193E', 'H193F', 'H193G', 'H193I', 'H193K', 'H193L', 'H193M', 'H193N', 'H193P', 'H193Q', 'H193R', 'H193S', 'H193T', 'H193V', 'H193W', 'H193Y', 'L194D', 'L194F', 'L194G', 'L194H', 'L194K', 'L194N', 'L194P', 'L194R', 'L194S', 'L194W', 'L194Y', 'I195A', 'I195D', 'I195E', 'I195F', 'I195G', 'I195H', 'I195K', 'I195N', 'I195P', 'I195Q', 'I195R', 'I195S', 'I195T', 'I195W', 'I195Y', 'R196A', 'R196C', 'R196D', 'R196E', 'R196F', 'R196G', 'R196H', 'R196I', 'R196L', 'R196M', 'R196N', 'R196P', 'R196Q', 'R196S', 'R196T', 'R196V', 'R196W', 'R196Y', 'V197A', 'V197C', 'V197D', 'V197E', 'V197F', 'V197G', 'V197H', 'V197K', 'V197L', 'V197M', 'V197N', 'V197P', 'V197Q', 'V197R', 'V197S', 'V197T', 'V197W', 'V197Y', 'E198A', 'E198C', 'E198D', 'E198F', 'E198G', 'E198H', 'E198I', 'E198K', 'E198L', 'E198M', 'E198N', 'E198P', 'E198Q', 'E198R', 'E198S', 'E198T', 'E198W', 'E198Y', 'G199I', 'G199P', 'G199T', 'G199V', 'N200A', 'N200C', 'N200E', 'N200F', 'N200G', 'N200I', 'N200K', 'N200L', 'N200M', 'N200P', 'N200Q', 'N200R', 'N200V', 'N200W', 'N200Y', 'V203C', 'V203D', 'V203E', 'V203F', 'V203H', 'V203K', 'V203L', 'V203M', 'V203N', 'V203P', 'V203Q', 'V203R', 'V203W', 'V203Y', 'E204P', 'Y205A', 'Y205C', 'Y205D', 'Y205E', 'Y205G', 'Y205H', 'Y205I', 'Y205K', 'Y205L', 'Y205M', 'Y205N', 'Y205P', 'Y205Q', 'Y205R', 'Y205S', 'Y205T', 'Y205V', 'Y205W', 'L206P', 'D208G', 'D208I', 'D208P', 'D208Y', 'T211A', 'T211C', 'T211D', 'T211E', 'T211F', 'T211G', 'T211H', 'T211I', 'T211K', 'T211L', 'T211M', 'T211P', 'T211Q', 'T211R', 'T211V', 'T211W', 'F212I', 'F212P', 'R213P', 'S215A', 'S215E', 'S215G', 'S215H', 'S215I', 'S215K', 'S215L', 'S215M', 'S215N', 'S215P', 'S215Q', 'S215T', 'S215V', 'S215W', 'S215Y', 'V216A', 'V216C', 'V216D', 'V216E', 'V216F', 'V216G', 'V216H', 'V216K', 'V216M', 'V216N', 'V216P', 'V216Q', 'V216R', 'V216S', 'V216T', 'V216W', 'V216Y', 'V217D', 'V217G', 'V217N', 'V217P', 'V217Y', 'V218A', 'V218C', 'V218D', 'V218E', 'V218F', 'V218G', 'V218H', 'V218K', 'V218N', 'V218P', 'V218Q', 'V218R', 'V218S', 'V218T', 'V218W', 'V218Y', 'Y220A', 'Y220C', 'Y220D', 'Y220E', 'Y220G', 'Y220H', 'Y220I', 'Y220K', 'Y220L', 'Y220M', 'Y220N', 'Y220P', 'Y220Q', 'Y220R', 'Y220S', 'Y220T', 'Y220V', 'Y220W', 'P222W', 'P223E', 'P223F', 'P223H', 'P223I', 'P223K', 'P223Q', 'P223R', 'P223W', 'P223Y', 'G226I', 'G226P', 'G226T', 'G226V', 'S227P', 'C229P', 'T230H', 'T230P', 'T230W', 'T230Y', 'I232A', 'I232C', 'I232D', 'I232E', 'I232F', 'I232G', 'I232H', 'I232K', 'I232N', 'I232P', 'I232Q', 'I232R', 'I232S', 'I232T', 'I232W', 'I232Y', 'H233P', 'Y234A', 'Y234C', 'Y234D', 'Y234E', 'Y234G', 'Y234H', 'Y234I', 'Y234K', 'Y234M', 'Y234N', 'Y234P', 'Y234Q', 'Y234R', 'Y234S', 'Y234T', 'Y234V', 'Y234W', 'N235P', 'Y236A', 'Y236C', 'Y236D', 'Y236E', 'Y236G', 'Y236H', 'Y236I', 'Y236K', 'Y236L', 'Y236M', 'Y236N', 'Y236P', 'Y236Q', 'Y236R', 'Y236S', 'Y236T', 'Y236V', 'Y236W', 'M237A', 'M237C', 'M237D', 'M237E', 'M237F', 'M237G', 'M237H', 'M237K', 'M237N', 'M237P', 'M237Q', 'M237R', 'M237S', 'M237T', 'M237V', 'M237W', 'M237Y', 'C238F', 'C238H', 'C238K', 'C238P', 'C238R', 'C238W', 'C238Y', 'S240H', 'S240P', 'S240W', 'S240Y', 'S241P', 'C242F', 'C242H', 'C242I', 'C242K', 'C242L', 'C242M', 'C242N', 'C242P', 'C242Q', 'C242R', 'C242T', 'C242V', 'C242W', 'C242Y', 'G244C', 'G244I', 'G244P', 'G244T', 'G244V', 'G245C', 'G245D', 'G245E', 'G245F', 'G245H', 'G245I', 'G245K', 'G245L', 'G245M', 'G245N', 'G245P', 'G245Q', 'G245R', 'G245S', 'G245T', 'G245V', 'G245W', 'G245Y', 'M246G', 'M246H', 'M246K', 'M246R', 'M246S', 'M246W', 'M246Y', 'N247I', 'N247P', 'R248P', 'R249A', 'R249C', 'R249D', 'R249E', 'R249F', 'R249G', 'R249H', 'R249I', 'R249K', 'R249L', 'R249M', 'R249N', 'R249P', 'R249Q', 'R249S', 'R249T', 'R249V', 'R249W', 'R249Y', 'I251A', 'I251C', 'I251D', 'I251E', 'I251F', 'I251G', 'I251H', 'I251K', 'I251N', 'I251P', 'I251Q', 'I251R', 'I251S', 'I251T', 'I251W', 'I251Y', 'L252D', 'L252E', 'L252G', 'L252H', 'L252N', 'L252P', 'L252S', 'T253D', 'T253G', 'T253K', 'T253P', 'T253R', 'T253W', 'T253Y', 'I254A', 'I254D', 'I254E', 'I254F', 'I254G', 'I254H', 'I254K', 'I254N', 'I254P', 'I254Q', 'I254R', 'I254S', 'I254W', 'I254Y', 'I255A', 'I255C', 'I255D', 'I255E', 'I255G', 'I255H', 'I255K', 'I255N', 'I255P', 'I255Q', 'I255R', 'I255S', 'I255T', 'I255W', 'I255Y', 'T256P', 'L257A', 'L257C', 'L257D', 'L257E', 'L257F', 'L257G', 'L257H', 'L257K', 'L257N', 'L257P', 'L257Q', 'L257R', 'L257S', 'L257T', 'L257W', 'L257Y', 'E258D', 'E258P', 'D259A', 'D259E', 'D259F', 'D259H', 'D259I', 'D259K', 'D259L', 'D259M', 'D259P', 'D259Q', 'D259R', 'D259V', 'D259W', 'D259Y', 'S261P', 'G262I', 'G262P', 'G262T', 'G262V', 'N263P', 'L264G', 'L265A', 'L265D', 'L265E', 'L265G', 'L265H', 'L265K', 'L265N', 'L265P', 'L265Q', 'L265R', 'L265S', 'L265T', 'G266C', 'G266D', 'G266E', 'G266F', 'G266H', 'G266I', 'G266K', 'G266L', 'G266M', 'G266N', 'G266P', 'G266Q', 'G266R', 'G266S', 'G266T', 'G266V', 'G266W', 'G266Y', 'R267D', 'R267G', 'R267P', 'R267W', 'R267Y', 'N268P', 'F270A', 'F270C', 'F270D', 'F270E', 'F270G', 'F270H', 'F270I', 'F270K', 'F270L', 'F270M', 'F270N', 'F270P', 'F270Q', 'F270R', 'F270S', 'F270T', 'F270V', 'F270W', 'V272A', 'V272D', 'V272E', 'V272F', 'V272G', 'V272H', 'V272K', 'V272N', 'V272P', 'V272Q', 'V272R', 'V272S', 'V272W', 'V272Y', 'R273P', 'V274D', 'V274E', 'V274F', 'V274G', 'V274H', 'V274K', 'V274N', 'V274P', 'V274Q', 'V274R', 'V274S', 'V274W', 'V274Y', 'C275A', 'C275D', 'C275E', 'C275F', 'C275G', 'C275H', 'C275I', 'C275K', 'C275L', 'C275M', 'C275N', 'C275P', 'C275Q', 'C275R', 'C275S', 'C275T', 'C275V', 'C275W', 'C275Y', 'C277P', 'P278D', 'P278E', 'P278F', 'P278H', 'P278I', 'P278K', 'P278L', 'P278M', 'P278N', 'P278Q', 'P278R', 'P278S', 'P278T', 'P278V', 'P278W', 'P278Y', 'G279C', 'G279D', 'G279E', 'G279F', 'G279H', 'G279I', 'G279K', 'G279L', 'G279M', 'G279N', 'G279P', 'G279Q', 'G279R', 'G279S', 'G279T', 'G279V', 'G279W', 'G279Y', 'R280P', 'D281G', 'D281P', 'R282D', 'R282P', 'R283P', 'T284C', 'T284D', 'T284E', 'T284F', 'T284H', 'T284I', 'T284K', 'T284P', 'T284Q', 'T284R', 'T284W', 'E285P', 'E286P', 'E287P', 'N288P', 'L289P'] + +- Experimental classification not available. + +- EfoldMine annotation not available. + +Not reported ClinVar Germline Interpretation in clinvar: 2970 +ClinVar Germline Interpretation +benign 5 +conflicting classifications of pathogenicity 232 +conflicting classifications of pathogenicity, conflicting classifications of pathogenicity 2 +conflicting classifications of pathogenicity, conflicting classifications of pathogenicity, conflicting classifications of pathogenicity 1 +conflicting classifications of pathogenicity, pathogenic/likely pathogenic 4 +likely benign 35 +likely benign, uncertain significance 1 +likely pathogenic 29 +likely pathogenic, conflicting classifications of pathogenicity 2 +likely pathogenic, conflicting classifications of pathogenicity, pathogenic/likely pathogenic 1 +likely pathogenic, pathogenic 1 +likely pathogenic, pathogenic/likely pathogenic 2 +not provided 1 +pathogenic 62 +pathogenic, conflicting classifications of pathogenicity 1 +pathogenic, pathogenic 3 +pathogenic, pathogenic, likely pathogenic 1 +pathogenic, pathogenic/likely pathogenic 4 +pathogenic/likely pathogenic 94 +pathogenic/likely pathogenic, conflicting classifications of pathogenicity 1 +pathogenic/likely pathogenic, likely pathogenic 1 +pathogenic/likely pathogenic, pathogenic 1 +pathogenic/likely pathogenic, pathogenic/likely pathogenic 1 +pathogenic/likely pathogenic, pathogenic/likely pathogenic, pathogenic 1 +uncertain significance 302 +uncertain significance, conflicting classifications of pathogenicity 6 +uncertain significance, conflicting classifications of pathogenicity, conflicting classifications of pathogenicity 1 +uncertain significance, conflicting classifications of pathogenicity, uncertain significance 2 +uncertain significance, likely benign 1 +uncertain significance, uncertain significance 13 +Name: ClinVar Germline Interpretation, dtype: int64 diff --git a/dot_plot/examples_v2/ensemble_mode_popeve/mechanistic_indicators_out.csv b/dot_plot/examples_v2/ensemble_mode_popeve/mechanistic_indicators_out.csv new file mode 100644 index 0000000..ac029ab --- /dev/null +++ b/dot_plot/examples_v2/ensemble_mode_popeve/mechanistic_indicators_out.csv @@ -0,0 +1,1193 @@ +Mutation,"Stability classification, (Rosetta, FoldX) [md]","Stability classification, (RaSP, FoldX) [md]",Stability classification (ThermoMPNN) [md],Stability classification (Foldetta from FoldX and Rosetta) [md],Stability classification (Foldetta from FoldX and RaSP) [md],"Stability classification, (Rosetta, FoldX) [cabsflex]","Stability classification, (RaSP, FoldX) [cabsflex]",Stability classification (Foldetta from FoldX and Rosetta) [cabsflex],Stability classification (Foldetta from FoldX and RaSP) [cabsflex],PTM effect in regulation [md],PTM effect in stability [md],PTM effect in function [md],PTM effect in regulation [cabsflex],PTM effect in stability [cabsflex],PTM effect in function [cabsflex],AlloSigMA2-PSN classification - pockets and interfaces [md],MAVISp Effects +P98A,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98E,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98G,,uncertain,neutral,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98H,uncertain,uncertain,neutral,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98I,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98K,,uncertain,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98L,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98M,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98Q,,uncertain,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98R,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +P98S,uncertain,uncertain,neutral,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98V,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98W,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P98Y,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +S99D,,neutral,neutral,,neutral,,neutral,,neutral,damaging,neutral,uncertain,damaging,neutral,uncertain,uncertain,PTM +S99H,,neutral,neutral,,neutral,,neutral,,neutral,damaging,neutral,uncertain,damaging,neutral,uncertain,uncertain,PTM +S99K,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,neutral,uncertain,damaging,neutral,uncertain,uncertain,PTM +S99M,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,neutral,uncertain,damaging,neutral,uncertain,uncertain,PTM +S99R,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,neutral,uncertain,damaging,neutral,uncertain,uncertain,PTM +S99W,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,neutral,uncertain,damaging,neutral,uncertain,uncertain,PTM +Y103A,,neutral,uncertain,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y103D,,neutral,uncertain,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y103E,,neutral,uncertain,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y103G,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y103I,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y103K,,neutral,uncertain,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y103L,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y103M,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y103N,,neutral,uncertain,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y103P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y103Q,,neutral,uncertain,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y103R,,neutral,uncertain,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y103S,,uncertain,uncertain,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y103T,,neutral,uncertain,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y103V,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +G105C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105D,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105E,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105F,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105H,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105I,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105K,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105L,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105M,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105N,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105Q,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105S,uncertain,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105T,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105V,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105W,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105Y,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +Y107A,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y107D,uncertain,uncertain,destabilizing,uncertain,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y107E,,uncertain,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y107G,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y107I,,uncertain,uncertain,,neutral,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y107K,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y107M,,uncertain,uncertain,,neutral,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y107P,,uncertain,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y107Q,uncertain,uncertain,destabilizing,neutral,uncertain,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y107R,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y107T,,uncertain,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +G108F,,uncertain,uncertain,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G108I,,uncertain,destabilizing,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G108P,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G108W,,uncertain,uncertain,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G108Y,,uncertain,uncertain,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109A,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109D,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109E,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109G,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109H,,uncertain,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109I,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109K,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109Q,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109R,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109T,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109V,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109W,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R110P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +L111A,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111C,,destabilizing,neutral,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111D,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111E,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111F,,uncertain,neutral,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111G,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111H,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111K,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111N,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111Q,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111S,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111T,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111W,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L111Y,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G112P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F113A,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113C,destabilizing,destabilizing,neutral,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113D,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113E,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113H,,uncertain,uncertain,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +F113I,uncertain,uncertain,neutral,destabilizing,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113K,,destabilizing,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113L,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +F113M,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +F113N,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113Q,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113R,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113S,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113T,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113V,destabilizing,uncertain,neutral,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F113W,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +S116P,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,destabilizing,uncertain,,,uncertain,,,uncertain,Stability +G117P,,uncertain,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +S121P,destabilizing,destabilizing,neutral,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,neutral,Stability +V122F,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V122H,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V122P,,uncertain,neutral,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V122W,,uncertain,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V122Y,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C124E,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C124H,,uncertain,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C124K,,uncertain,uncertain,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C124P,,uncertain,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C124Q,,neutral,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C124R,destabilizing,uncertain,uncertain,destabilizing,uncertain,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C124Y,destabilizing,uncertain,neutral,destabilizing,neutral,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +T125A,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,,,uncertain,,,damaging,Long Range +T125C,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +T125F,,uncertain,neutral,,destabilizing,,uncertain,,destabilizing,uncertain,,,uncertain,,,neutral,Stability +T125G,,uncertain,uncertain,,uncertain,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,Long Range +T125H,,uncertain,neutral,,destabilizing,,uncertain,,destabilizing,uncertain,,,uncertain,,,neutral,Stability +T125K,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,uncertain,uncertain,,,uncertain,,,neutral,Stability +T125P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,uncertain,,,uncertain,Stability +T125R,destabilizing,uncertain,neutral,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,uncertain,,,neutral,Stability +T125S,,neutral,neutral,,neutral,,neutral,,neutral,neutral,,,neutral,,,damaging,Long Range +T125W,,uncertain,neutral,,destabilizing,,uncertain,,destabilizing,uncertain,,,uncertain,,,neutral,Stability +T125Y,,uncertain,neutral,,destabilizing,,uncertain,,destabilizing,uncertain,,,uncertain,,,neutral,Stability +Y126A,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,damaging,uncertain,uncertain,neutral,uncertain,uncertain,"Stability, PTM" +Y126C,uncertain,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,Stability +Y126D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,damaging,uncertain,uncertain,neutral,uncertain,uncertain,"Stability, PTM" +Y126E,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,uncertain,damaging,uncertain,uncertain,neutral,uncertain,uncertain,"Stability, PTM" +Y126G,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,uncertain,damaging,uncertain,uncertain,neutral,uncertain,uncertain,"Stability, PTM" +Y126H,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,Stability +Y126K,,uncertain,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,Stability +Y126N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,damaging,uncertain,uncertain,neutral,uncertain,uncertain,"Stability, PTM" +Y126P,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,uncertain,damaging,uncertain,uncertain,neutral,uncertain,uncertain,"Stability, PTM" +Y126Q,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,damaging,uncertain,uncertain,neutral,uncertain,uncertain,"Stability, PTM" +Y126R,,uncertain,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,damaging,uncertain,uncertain,neutral,uncertain,uncertain,"Stability, PTM" +Y126S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,uncertain,uncertain,damaging,uncertain,uncertain,neutral,uncertain,uncertain,"Stability, PTM" +Y126T,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,damaging,uncertain,uncertain,neutral,uncertain,uncertain,"Stability, PTM" +S127D,,uncertain,uncertain,,destabilizing,,neutral,,neutral,uncertain,,,uncertain,,,uncertain,Stability +S127E,,destabilizing,destabilizing,,destabilizing,,neutral,,neutral,uncertain,,,uncertain,,,uncertain,Stability +S127F,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,uncertain,,,uncertain,,,uncertain,Stability +S127G,,neutral,destabilizing,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,uncertain,Stability +S127H,,uncertain,uncertain,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,uncertain,Stability +S127K,,destabilizing,destabilizing,,destabilizing,,neutral,,neutral,uncertain,,,uncertain,,,uncertain,Stability +S127L,,uncertain,destabilizing,,uncertain,,neutral,,neutral,uncertain,,,uncertain,,,uncertain,Stability +S127M,,uncertain,destabilizing,,uncertain,,neutral,,neutral,uncertain,,,uncertain,,,uncertain,Stability +S127P,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,uncertain,,,uncertain,,,uncertain,Stability +S127Q,,uncertain,destabilizing,,destabilizing,,neutral,,neutral,uncertain,,,uncertain,,,uncertain,Stability +S127R,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,uncertain,Stability +S127V,,neutral,destabilizing,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,uncertain,Stability +S127W,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,uncertain,Stability +S127Y,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,neutral,uncertain,neutral,uncertain,,,uncertain,,,uncertain,Stability +L130P,uncertain,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +N131P,,destabilizing,destabilizing,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +K132D,,uncertain,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +K132P,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133D,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133E,,uncertain,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133F,,uncertain,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +M133G,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133H,,uncertain,destabilizing,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +M133N,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133Q,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133R,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +M133S,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133T,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133W,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +M133Y,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F134A,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F134C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F134D,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F134E,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F134G,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F134K,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F134N,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F134P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F134Q,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F134R,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F134S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F134T,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C135D,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C135E,,uncertain,destabilizing,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C135F,uncertain,uncertain,neutral,destabilizing,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C135H,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C135K,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C135P,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C135Q,,neutral,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C135R,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C135W,destabilizing,uncertain,neutral,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C135Y,destabilizing,uncertain,neutral,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +Q136A,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136C,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136D,,neutral,destabilizing,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +Q136E,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136F,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136G,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136H,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136I,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136K,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136L,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136M,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136N,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +Q136S,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136T,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136W,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q136Y,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138C,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138D,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138E,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138F,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138H,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138I,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138K,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138L,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138M,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138N,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +A138Q,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138R,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138T,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138V,uncertain,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138W,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A138Y,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +K139P,,uncertain,destabilizing,,uncertain,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C141E,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C141F,uncertain,uncertain,neutral,destabilizing,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C141G,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C141H,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C141K,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C141P,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C141R,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C141W,destabilizing,uncertain,neutral,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C141Y,destabilizing,uncertain,neutral,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P142D,,uncertain,destabilizing,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +P142H,uncertain,uncertain,uncertain,destabilizing,neutral,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V143A,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V143D,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V143E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V143G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V143H,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V143K,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V143N,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V143P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V143Q,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V143R,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V143S,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V143T,,neutral,destabilizing,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V143W,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V143Y,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +Q144P,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L145A,,destabilizing,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145C,,destabilizing,neutral,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145D,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145E,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145G,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145H,,uncertain,destabilizing,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145K,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L145N,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145Q,uncertain,uncertain,destabilizing,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145S,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145W,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145Y,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +W146D,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +W146P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V147D,uncertain,uncertain,destabilizing,uncertain,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V147E,uncertain,uncertain,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V147F,neutral,neutral,uncertain,neutral,neutral,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V147G,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V147H,,uncertain,destabilizing,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V147K,,uncertain,destabilizing,,uncertain,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V147N,,uncertain,destabilizing,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V147P,,uncertain,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V147Q,,uncertain,destabilizing,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V147R,,uncertain,destabilizing,,uncertain,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V147W,,uncertain,uncertain,,uncertain,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V147Y,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +P151A,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P151D,,uncertain,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +P151E,,uncertain,uncertain,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P151F,destabilizing,uncertain,neutral,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +P151G,,uncertain,uncertain,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +P151H,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +P151I,,uncertain,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P151K,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +P151M,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P151N,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +P151Q,,uncertain,uncertain,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P151R,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +P151W,,uncertain,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +P151Y,,uncertain,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +P152W,,neutral,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G154I,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G154P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G154V,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +T155D,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,uncertain,neutral,uncertain,uncertain,neutral,uncertain,uncertain,Stability +T155E,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,uncertain,neutral,uncertain,uncertain,neutral,uncertain,neutral,Stability +T155F,uncertain,uncertain,uncertain,destabilizing,neutral,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,neutral,Stability +T155H,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,uncertain,neutral,uncertain,uncertain,neutral,uncertain,neutral,Stability +T155K,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,neutral,Stability +T155L,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,damaging,uncertain,uncertain,damaging,uncertain,neutral,PTM +T155P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,uncertain,uncertain,damaging,uncertain,uncertain,"Stability, PTM" +T155Q,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,neutral,Stability +T155R,,uncertain,destabilizing,,uncertain,,uncertain,,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,neutral,Stability +T155W,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,uncertain,neutral,uncertain,uncertain,neutral,uncertain,neutral,Stability +T155Y,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,uncertain,neutral,uncertain,uncertain,neutral,uncertain,neutral,Stability +R156D,,uncertain,destabilizing,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R156P,uncertain,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V157D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V157G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157H,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157K,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157N,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157Q,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V157R,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157S,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157W,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157Y,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R158A,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158C,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158D,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +R158E,,uncertain,uncertain,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158F,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158G,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +R158H,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +R158I,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158L,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158M,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158N,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158P,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +R158Q,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158S,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158T,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158V,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158W,,uncertain,neutral,,neutral,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R158Y,,uncertain,neutral,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +A159D,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +A159F,uncertain,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +A159H,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +A159I,neutral,neutral,stabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +A159K,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +A159P,uncertain,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +A159R,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +A159W,,destabilizing,neutral,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +A159Y,,uncertain,neutral,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +M160A,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M160C,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M160D,,uncertain,uncertain,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M160E,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M160F,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M160G,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +M160H,,uncertain,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M160K,uncertain,neutral,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M160N,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M160P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +M160Q,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M160R,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M160S,,uncertain,uncertain,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M160W,,uncertain,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M160Y,,uncertain,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A161D,uncertain,uncertain,uncertain,uncertain,uncertain,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161E,,neutral,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161F,destabilizing,uncertain,neutral,destabilizing,uncertain,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161H,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161K,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161N,neutral,neutral,uncertain,neutral,neutral,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161R,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161W,,uncertain,neutral,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161Y,,uncertain,neutral,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162D,,uncertain,destabilizing,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162E,,uncertain,destabilizing,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162F,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162G,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162H,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162K,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I162N,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162P,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162R,,uncertain,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162W,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162Y,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +Y163A,,uncertain,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,uncertain,Stability +Y163C,uncertain,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,uncertain,Stability +Y163D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,uncertain,,,uncertain,,,uncertain,Stability +Y163E,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,uncertain,Stability +Y163G,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,uncertain,Stability +Y163K,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,uncertain,Stability +Y163N,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,uncertain,Stability +Y163P,,uncertain,uncertain,,destabilizing,,uncertain,,uncertain,uncertain,,,uncertain,,,uncertain,Stability +Y163Q,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,uncertain,Stability +Y163R,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,uncertain,Stability +Y163S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,uncertain,Stability +Y163T,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,uncertain,Stability +K164P,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +Q165C,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q165D,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +Q165P,uncertain,uncertain,neutral,neutral,neutral,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +H168A,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H168C,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H168E,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H168G,,uncertain,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H168I,,neutral,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H168K,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H168L,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H168M,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H168P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +H168R,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H168S,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H168T,,neutral,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H168V,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H168W,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M169P,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +E171P,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V172F,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V172H,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V172P,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V172R,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V172W,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V172Y,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173A,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V173C,,uncertain,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V173D,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V173E,uncertain,uncertain,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V173F,,uncertain,uncertain,,uncertain,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173G,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V173H,,uncertain,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173K,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173M,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173N,,uncertain,uncertain,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V173P,,uncertain,uncertain,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V173Q,destabilizing,uncertain,uncertain,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V173R,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173S,,uncertain,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V173T,,uncertain,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V173W,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173Y,,uncertain,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R174D,,neutral,destabilizing,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R174E,uncertain,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R174P,,uncertain,destabilizing,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R175A,,neutral,neutral,,neutral,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175D,,uncertain,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175E,,uncertain,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175F,,uncertain,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R175G,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175H,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +R175I,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175L,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175M,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175N,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175P,neutral,uncertain,neutral,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175Q,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175S,neutral,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175T,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175V,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R175W,,uncertain,neutral,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R175Y,,uncertain,neutral,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C176F,neutral,neutral,neutral,neutral,neutral,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C176H,,uncertain,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C176I,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C176K,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C176L,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C176M,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C176N,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C176P,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C176Q,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C176R,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C176V,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C176W,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C176Y,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +H178P,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +H179A,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179C,,neutral,neutral,,neutral,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179D,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179E,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179F,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +H179G,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179I,,neutral,neutral,,neutral,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179K,,neutral,neutral,,neutral,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179L,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179M,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179N,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179P,uncertain,uncertain,neutral,uncertain,neutral,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +H179R,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +H179S,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179T,,neutral,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179V,,neutral,neutral,,neutral,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H179W,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +H179Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +E180P,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R181P,destabilizing,destabilizing,neutral,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C182P,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +D186F,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +D186I,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +D186K,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +D186L,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +D186P,,uncertain,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +D186R,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +D186V,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +D186W,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +G187P,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +A189F,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189G,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +A189H,,uncertain,neutral,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189K,,destabilizing,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189P,uncertain,uncertain,neutral,uncertain,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189R,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189W,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189Y,,uncertain,neutral,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P190E,,uncertain,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P190F,uncertain,uncertain,uncertain,neutral,neutral,destabilizing,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +P190G,,uncertain,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P190I,,uncertain,uncertain,,neutral,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P190K,,uncertain,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P190L,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P190M,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P190R,neutral,neutral,uncertain,neutral,neutral,destabilizing,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +P190V,,uncertain,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +P190W,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +P190Y,,uncertain,uncertain,,neutral,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193A,,neutral,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193C,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193D,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193E,,uncertain,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193F,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193G,,uncertain,uncertain,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193I,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193K,,uncertain,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193L,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193M,,neutral,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193N,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193P,uncertain,uncertain,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +H193Q,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193R,uncertain,uncertain,uncertain,uncertain,uncertain,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +H193S,,uncertain,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193T,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193V,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +H193W,,uncertain,neutral,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +H193Y,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +L194D,,destabilizing,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L194F,uncertain,uncertain,neutral,uncertain,neutral,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L194G,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L194H,uncertain,uncertain,uncertain,uncertain,uncertain,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L194K,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L194N,,uncertain,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L194P,uncertain,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L194R,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L194S,,destabilizing,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L194W,,uncertain,neutral,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L194Y,,uncertain,neutral,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195A,,uncertain,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195D,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195E,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195F,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I195G,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195H,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I195N,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195P,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195Q,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195R,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I195S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195T,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195W,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I195Y,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +R196A,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196C,,uncertain,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196D,,uncertain,neutral,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196E,,uncertain,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196F,,neutral,neutral,,neutral,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196G,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196H,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +R196I,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196L,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196M,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196N,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +R196Q,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196S,,uncertain,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196T,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196V,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196W,,neutral,neutral,,neutral,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +R196Y,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V197A,uncertain,uncertain,uncertain,destabilizing,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V197C,,uncertain,uncertain,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V197D,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V197E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V197F,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V197G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V197H,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V197K,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V197N,,destabilizing,destabilizing,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V197P,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V197Q,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V197R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V197S,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V197T,,uncertain,uncertain,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V197W,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V197Y,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +E198A,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198C,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198D,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198F,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198G,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198H,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198I,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198K,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198L,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198M,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198N,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198P,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +E198Q,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198R,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198S,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198T,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198W,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +E198Y,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +G199I,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G199P,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G199T,uncertain,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G199V,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +N200A,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +N200C,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +N200E,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +N200F,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +N200K,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +N200L,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +N200M,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +N200P,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +N200Q,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +N200R,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +N200V,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +N200W,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +N200Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V203D,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V203E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V203F,,uncertain,uncertain,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V203H,,uncertain,destabilizing,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V203K,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V203M,uncertain,neutral,uncertain,destabilizing,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V203N,,uncertain,destabilizing,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V203P,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V203Q,,uncertain,destabilizing,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V203R,,uncertain,destabilizing,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V203W,,uncertain,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V203Y,,uncertain,uncertain,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +E204P,,uncertain,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +Y205A,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205E,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205G,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205H,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,neutral,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205I,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205K,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205L,,uncertain,destabilizing,,neutral,,neutral,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205M,,uncertain,destabilizing,,neutral,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,uncertain,neutral,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205P,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205Q,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205R,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205T,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205V,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y205W,,uncertain,neutral,,neutral,,uncertain,,uncertain,uncertain,,,uncertain,,,damaging,Long Range +D208G,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +D208I,uncertain,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +D208P,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +D208Y,uncertain,uncertain,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +T211C,,neutral,neutral,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211D,,neutral,neutral,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211E,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211F,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211G,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211H,,neutral,neutral,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211I,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211K,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211L,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211M,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211P,uncertain,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,destabilizing,uncertain,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,"Stability, PTM" +T211Q,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211R,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211V,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211W,,neutral,uncertain,,neutral,,neutral,,neutral,damaging,damaging,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T211Y,,neutral,uncertain,,neutral,,neutral,,neutral,uncertain,damaging,potentially_damaging,uncertain,neutral,potentially_damaging,uncertain,PTM +F212P,,destabilizing,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R213P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +S215A,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,damaging,uncertain,uncertain,damaging,uncertain,uncertain,PTM +S215E,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,damaging,uncertain,uncertain,damaging,uncertain,neutral,PTM +S215G,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,damaging,uncertain,uncertain,damaging,uncertain,uncertain,PTM +S215H,,uncertain,neutral,,neutral,,uncertain,,destabilizing,uncertain,neutral,uncertain,uncertain,neutral,uncertain,neutral,Stability +S215I,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,damaging,uncertain,uncertain,damaging,uncertain,neutral,PTM +S215K,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,damaging,uncertain,uncertain,damaging,uncertain,neutral,PTM +S215L,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,damaging,uncertain,uncertain,damaging,uncertain,neutral,PTM +S215N,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,damaging,uncertain,uncertain,damaging,uncertain,neutral,PTM +S215P,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,neutral,Stability +S215Q,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,damaging,uncertain,uncertain,damaging,uncertain,neutral,PTM +S215T,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,uncertain,neutral,damaging,uncertain,neutral,PTM +S215V,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,damaging,uncertain,uncertain,damaging,uncertain,neutral,PTM +S215W,,uncertain,neutral,,neutral,,uncertain,,destabilizing,uncertain,neutral,uncertain,uncertain,neutral,uncertain,neutral,Stability +S215Y,,uncertain,neutral,,neutral,,uncertain,,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,neutral,Stability +V216A,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V216C,,uncertain,uncertain,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V216D,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V216E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V216F,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V216G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V216H,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V216K,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V216M,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V216N,,uncertain,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V216P,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V216Q,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V216R,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V216S,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V216T,,uncertain,uncertain,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V216W,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V216Y,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V217D,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V217N,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V217P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V218A,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V218C,,neutral,neutral,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V218D,,uncertain,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V218E,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V218F,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V218G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V218H,,uncertain,destabilizing,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V218K,,uncertain,destabilizing,,uncertain,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V218N,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V218P,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V218Q,,neutral,destabilizing,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V218R,,uncertain,destabilizing,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V218S,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +V218T,,uncertain,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V218W,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V218Y,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +Y220A,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,neutral,uncertain,damaging,damaging,uncertain,damaging,"Stability, PTM, Long Range" +Y220C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,damaging,damaging,uncertain,damaging,"Stability, PTM, Long Range" +Y220D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,neutral,uncertain,damaging,damaging,uncertain,damaging,"Stability, PTM, Long Range" +Y220E,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,neutral,uncertain,damaging,damaging,uncertain,damaging,"Stability, PTM, Long Range" +Y220G,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,neutral,uncertain,damaging,damaging,uncertain,damaging,"Stability, PTM, Long Range" +Y220H,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,uncertain,damaging,"PTM, Long Range" +Y220I,,neutral,uncertain,,neutral,,neutral,,neutral,uncertain,damaging,uncertain,damaging,damaging,uncertain,damaging,"PTM, Long Range" +Y220K,,uncertain,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,uncertain,uncertain,damaging,damaging,uncertain,damaging,"Stability, PTM, Long Range" +Y220L,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,neutral,neutral,uncertain,damaging,uncertain,damaging,damaging,uncertain,damaging,"PTM, Long Range" +Y220M,,neutral,uncertain,,neutral,,neutral,,neutral,uncertain,damaging,uncertain,damaging,damaging,uncertain,damaging,"PTM, Long Range" +Y220N,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,damaging,damaging,uncertain,damaging,"Stability, PTM, Long Range" +Y220P,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,uncertain,neutral,uncertain,damaging,uncertain,uncertain,damaging,"Stability, PTM, Long Range" +Y220Q,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,uncertain,uncertain,uncertain,damaging,damaging,uncertain,damaging,"Stability, PTM, Long Range" +Y220R,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,uncertain,uncertain,uncertain,damaging,damaging,uncertain,damaging,"Stability, PTM, Long Range" +Y220S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,neutral,uncertain,uncertain,damaging,uncertain,damaging,"Stability, PTM, Long Range" +Y220T,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,neutral,uncertain,uncertain,damaging,uncertain,damaging,"Stability, PTM, Long Range" +Y220V,,uncertain,uncertain,,uncertain,,neutral,,neutral,uncertain,uncertain,uncertain,damaging,damaging,uncertain,damaging,"PTM, Long Range" +Y220W,,neutral,neutral,,neutral,,uncertain,,neutral,uncertain,damaging,uncertain,damaging,uncertain,uncertain,neutral,PTM +P222W,,uncertain,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +P223E,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223F,,neutral,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223H,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223I,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223K,,neutral,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223Q,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223R,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223W,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223Y,,neutral,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G226I,,uncertain,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G226P,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G226T,,uncertain,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G226V,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C229P,,uncertain,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +T230H,,neutral,neutral,,neutral,,uncertain,,destabilizing,uncertain,,,uncertain,,,neutral,Stability +T230P,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,neutral,destabilizing,uncertain,,,uncertain,,,uncertain,Stability +T230W,,neutral,neutral,,neutral,,uncertain,,destabilizing,uncertain,,,uncertain,,,neutral,Stability +T230Y,,neutral,neutral,,neutral,,uncertain,,destabilizing,uncertain,,,uncertain,,,neutral,Stability +I232A,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I232C,,uncertain,uncertain,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +I232D,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I232E,,uncertain,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I232G,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I232H,,uncertain,destabilizing,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I232K,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I232N,uncertain,uncertain,destabilizing,uncertain,destabilizing,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I232P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I232Q,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I232R,,uncertain,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I232S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I232W,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +I232Y,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +H233P,neutral,uncertain,uncertain,neutral,neutral,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +Y234A,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y234C,destabilizing,destabilizing,neutral,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y234D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y234E,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y234G,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y234H,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y234I,,uncertain,neutral,,uncertain,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y234K,,destabilizing,uncertain,,destabilizing,,uncertain,,uncertain,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y234M,,uncertain,neutral,,neutral,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y234N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y234P,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y234Q,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y234R,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y234S,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y234T,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y234V,,uncertain,neutral,,uncertain,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y234W,,neutral,neutral,,neutral,,uncertain,,uncertain,uncertain,,,uncertain,,,damaging,Long Range +N235P,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +Y236A,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,uncertain,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236E,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236G,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236H,destabilizing,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,neutral,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236I,,uncertain,uncertain,,uncertain,,neutral,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y236K,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236L,uncertain,neutral,uncertain,uncertain,neutral,uncertain,uncertain,neutral,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y236M,,neutral,uncertain,,neutral,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y236N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236P,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236Q,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236R,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,uncertain,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236T,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,"Stability, Long Range" +Y236V,,uncertain,uncertain,,uncertain,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,Long Range +Y236W,,neutral,neutral,,neutral,,uncertain,,neutral,uncertain,,,uncertain,,,damaging,Long Range +M237A,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237C,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237D,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237E,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237F,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237G,,uncertain,uncertain,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237H,,uncertain,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237K,uncertain,neutral,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +M237N,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +M237Q,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237R,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237S,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237T,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237V,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237W,,uncertain,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +M237Y,,neutral,uncertain,,neutral,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +C238F,destabilizing,uncertain,neutral,destabilizing,uncertain,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C238H,,uncertain,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C238K,,neutral,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C238P,,uncertain,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C238R,uncertain,uncertain,neutral,destabilizing,neutral,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C238W,destabilizing,uncertain,neutral,destabilizing,uncertain,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C238Y,destabilizing,uncertain,neutral,destabilizing,uncertain,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +S240H,,uncertain,neutral,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,neutral,Stability +S240P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,,,uncertain,,,neutral,Stability +S240W,,uncertain,uncertain,,destabilizing,,uncertain,,neutral,uncertain,,,uncertain,,,neutral,Stability +S240Y,,uncertain,uncertain,,destabilizing,,neutral,,neutral,uncertain,,,uncertain,,,neutral,Stability +S241P,uncertain,uncertain,neutral,destabilizing,neutral,uncertain,neutral,uncertain,neutral,uncertain,,,uncertain,,,neutral,Stability +C242F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C242H,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C242I,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C242K,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C242L,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C242M,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C242N,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C242P,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C242Q,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C242R,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C242T,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C242V,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C242W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C242Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G244C,neutral,neutral,neutral,neutral,neutral,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G244I,,uncertain,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G244P,,uncertain,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G244T,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G244V,neutral,neutral,neutral,neutral,neutral,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245C,neutral,uncertain,neutral,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245D,uncertain,uncertain,uncertain,neutral,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245E,uncertain,destabilizing,uncertain,neutral,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245F,uncertain,uncertain,neutral,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245H,uncertain,uncertain,neutral,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245I,uncertain,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245K,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245L,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245M,,uncertain,neutral,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245N,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245P,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245Q,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245R,uncertain,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245S,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245T,,uncertain,neutral,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245V,uncertain,uncertain,uncertain,neutral,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245W,,uncertain,neutral,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G245Y,uncertain,uncertain,neutral,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +M246G,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +M246H,,uncertain,uncertain,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +M246K,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +M246R,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +M246S,,uncertain,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +M246W,,uncertain,neutral,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +M246Y,,uncertain,neutral,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +N247I,uncertain,uncertain,uncertain,destabilizing,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +N247P,,destabilizing,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R248P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R249A,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249C,,neutral,neutral,,neutral,,uncertain,,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249D,,uncertain,uncertain,,uncertain,,uncertain,,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249E,,uncertain,neutral,,neutral,,uncertain,,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249F,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249G,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249H,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249I,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249K,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,uncertain,PTM +R249L,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249M,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249N,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249P,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"Stability, PTM, Long Range" +R249Q,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249S,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249T,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249V,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249W,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +R249Y,,neutral,neutral,,neutral,,neutral,,neutral,uncertain,neutral,neutral,damaging,neutral,neutral,damaging,"PTM, Long Range" +I251A,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I251C,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I251D,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I251E,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I251F,uncertain,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I251G,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I251H,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I251K,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I251N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I251P,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I251Q,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I251R,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I251S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I251T,uncertain,uncertain,destabilizing,uncertain,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I251W,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I251Y,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L252D,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L252E,,uncertain,destabilizing,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L252G,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L252H,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L252N,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L252P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L252S,,destabilizing,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +T253D,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,uncertain,neutral,neutral,uncertain,,,uncertain,,,uncertain,Stability +T253G,,destabilizing,uncertain,,destabilizing,,uncertain,,uncertain,uncertain,,,uncertain,,,neutral,Stability +T253K,,uncertain,uncertain,,destabilizing,,uncertain,,uncertain,uncertain,,,uncertain,,,neutral,Stability +T253P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,uncertain,,,uncertain,,,uncertain,Stability +T253R,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,uncertain,,,uncertain,,,neutral,Stability +T253W,,uncertain,neutral,,destabilizing,,uncertain,,destabilizing,uncertain,,,uncertain,,,neutral,Stability +T253Y,,uncertain,neutral,,uncertain,,uncertain,,destabilizing,uncertain,,,uncertain,,,neutral,Stability +I254A,,uncertain,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254D,uncertain,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254E,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254F,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254G,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254H,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254K,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I254N,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254Q,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254R,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254W,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254Y,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I255A,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I255C,,destabilizing,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I255D,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I255E,,uncertain,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I255G,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I255H,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I255K,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I255N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I255P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I255Q,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I255R,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I255S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +I255W,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I255Y,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +T256P,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,uncertain,,,uncertain,,,uncertain,Stability +L257A,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257C,,destabilizing,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257D,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257E,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257F,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257G,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257H,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257K,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L257N,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257Q,uncertain,destabilizing,destabilizing,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257S,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257T,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257W,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257Y,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +E258D,neutral,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +E258P,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259F,uncertain,neutral,destabilizing,uncertain,neutral,destabilizing,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259I,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259K,,neutral,destabilizing,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259L,,neutral,destabilizing,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259P,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +D259Q,,neutral,destabilizing,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259R,,neutral,destabilizing,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259V,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259W,,neutral,destabilizing,,neutral,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +S261P,,uncertain,destabilizing,,neutral,,uncertain,,uncertain,uncertain,,,uncertain,,,neutral,Stability +G262I,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G262P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G262T,,uncertain,uncertain,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +G262V,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +N263P,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L264G,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265A,,uncertain,destabilizing,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265D,,uncertain,destabilizing,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265E,,uncertain,destabilizing,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265G,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265H,,neutral,destabilizing,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265K,,uncertain,destabilizing,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +L265N,,uncertain,destabilizing,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265Q,neutral,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265R,uncertain,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265S,,uncertain,destabilizing,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265T,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266C,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266D,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266F,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266H,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266I,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266L,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266M,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266N,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266Q,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266S,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266T,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266V,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266W,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266Y,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R267D,,uncertain,destabilizing,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R267G,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R267P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R267W,uncertain,uncertain,neutral,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R267Y,,uncertain,neutral,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +N268P,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +F270A,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270D,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270E,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270G,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270H,,uncertain,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270I,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +F270K,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270L,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +F270M,,uncertain,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +F270N,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270Q,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270R,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270T,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270V,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +F270W,,uncertain,uncertain,,uncertain,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +V272D,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V272E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V272F,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V272H,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V272K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V272N,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V272P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V272Q,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V272R,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V272S,,destabilizing,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V272W,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V272Y,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R273P,uncertain,uncertain,destabilizing,uncertain,destabilizing,uncertain,uncertain,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V274D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V274E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V274F,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V274G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V274H,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V274K,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V274N,,uncertain,destabilizing,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V274P,,uncertain,uncertain,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V274Q,,uncertain,destabilizing,,destabilizing,,uncertain,,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +V274R,,destabilizing,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V274S,,destabilizing,destabilizing,,destabilizing,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V274W,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V274Y,,destabilizing,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +C275A,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +C275D,,uncertain,destabilizing,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C275E,,uncertain,uncertain,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +C275F,uncertain,uncertain,neutral,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +C275G,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +C275H,,uncertain,uncertain,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +C275I,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +C275K,,destabilizing,uncertain,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +C275L,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +C275M,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +C275N,,neutral,uncertain,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +C275P,,destabilizing,destabilizing,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +C275Q,,uncertain,uncertain,,uncertain,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +C275R,uncertain,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +C275S,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +C275T,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +C275V,,neutral,neutral,,neutral,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Long Range +C275W,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +C275Y,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,"Stability, Long Range" +C277P,,uncertain,destabilizing,,uncertain,,uncertain,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +P278D,,uncertain,destabilizing,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +P278E,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278F,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278H,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278I,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278K,,uncertain,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278L,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278M,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278N,,uncertain,uncertain,,uncertain,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +P278Q,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278R,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278S,destabilizing,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +P278T,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +P278V,uncertain,uncertain,neutral,destabilizing,neutral,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278W,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278Y,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279C,,neutral,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279D,neutral,neutral,neutral,neutral,neutral,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279E,neutral,neutral,neutral,neutral,neutral,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279F,,neutral,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279H,,uncertain,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279I,,neutral,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279K,,neutral,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279L,,neutral,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279M,,neutral,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279N,,neutral,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279P,,uncertain,uncertain,,uncertain,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279Q,,neutral,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279R,neutral,neutral,neutral,neutral,neutral,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279S,,neutral,neutral,,neutral,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279T,,uncertain,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279V,neutral,neutral,neutral,neutral,neutral,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279W,neutral,neutral,neutral,neutral,neutral,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279Y,,neutral,neutral,,neutral,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R280P,uncertain,uncertain,neutral,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D281G,uncertain,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +D281P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R282D,,uncertain,uncertain,,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R282P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +R283P,uncertain,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +T284D,,neutral,neutral,,neutral,,neutral,,neutral,damaging,neutral,potentially_damaging,damaging,neutral,potentially_damaging,uncertain,PTM +T284E,,neutral,neutral,,neutral,,neutral,,neutral,damaging,neutral,potentially_damaging,damaging,neutral,potentially_damaging,neutral,PTM +T284F,,neutral,neutral,,neutral,,neutral,,neutral,damaging,neutral,potentially_damaging,damaging,neutral,potentially_damaging,neutral,PTM +T284K,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,neutral,potentially_damaging,damaging,neutral,potentially_damaging,neutral,PTM +T284P,uncertain,uncertain,neutral,destabilizing,uncertain,uncertain,uncertain,destabilizing,destabilizing,damaging,neutral,potentially_damaging,damaging,uncertain,potentially_damaging,uncertain,"Stability, PTM" +T284R,,neutral,neutral,,neutral,,neutral,,neutral,damaging,neutral,potentially_damaging,damaging,neutral,potentially_damaging,neutral,PTM +T284W,,neutral,neutral,,neutral,,neutral,,neutral,damaging,neutral,potentially_damaging,damaging,neutral,potentially_damaging,neutral,PTM +E285P,,uncertain,uncertain,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +E286P,,destabilizing,uncertain,,destabilizing,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +E287P,,uncertain,neutral,,uncertain,,destabilizing,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability +N288P,,destabilizing,neutral,,destabilizing,,uncertain,,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,Stability diff --git a/dot_plot/examples_v2/simple_mode_popeve/TP53-simple_mode.csv b/dot_plot/examples_v2/simple_mode_popeve/TP53-simple_mode.csv new file mode 100644 index 0000000..99de26d --- /dev/null +++ b/dot_plot/examples_v2/simple_mode_popeve/TP53-simple_mode.csv @@ -0,0 +1,3782 @@ +Mutation,HGVSp,HGVSg,gnomAD genome allele frequency,gnomAD exome allele frequency,REVEL score,Mutation sources,ClinVar Variation ID,ClinVar Germline Interpretation,ClinVar Germline Review Status,ClinVar Oncogenicity Interpretation,ClinVar Oncogenicity Review Status,ClinVar Clinical Impact Interpretation,ClinVar Clinical Impact Review Status,Pfam domain classification,TED-CATH domain classification,"Stability (FoldX5, alphafold, kcal/mol)","Stability (ThermoMPNN, alphafold, kcal/mol)","Stability (Rosetta Cartddg2020, alphafold, kcal/mol)","Stability (RaSP, alphafold, kcal/mol)","Stability (Foldetta from FoldX and Rosetta, alphafold, kcal/mol)","Stability (Foldetta from FoldX and RaSP, alphafold, kcal/mol)","Stability classification, alphafold, (Rosetta, FoldX)","Stability classification, alphafold, (RaSP, FoldX)","Stability classification, alphafold, (ThermoMPNN)","Stability classification, alphafold, (Foldetta from FoldX and Rosetta)","Stability classification, alphafold, (Foldetta from FoldX and RaSP)",EFoldMine - part of early folding region,EFoldMine score,"Local Int. (Binding with TP53BP1_AFmulti, heterodimer, FoldX5, kcal/mol)","Local Int. (Binding with TP53BP1_AFmulti, heterodimer, Rosetta Talaris 2014, kcal/mol)",Local Int. classification (TP53BP1_AFmulti),"Local Int. With DNA (3KZ8b, heterodimer, FoldX5, kcal/mol)",Local Int. With DNA classification (3KZ8b),"Local Int. (Binding with TP53_2OCJbd, homodimer, FoldX5, kcal/mol)","Local Int. (Binding with TP53_2OCJbd, homodimer, Rosetta Talaris 2014, kcal/mol)",Local Int. classification (TP53_2OCJbd),Relative Side Chain Solvent Accessibility in wild-type,PTMs,is site part of phospho-SLiM,PTM residue SASA (%),"Change in stability with PTM (FoldX5, kcal/mol)",PTM effect in regulation,PTM effect in stability,PTM effect in function,AlloSigMA 2 mutation type,AlloSigMA 2 predicted consequence - pockets and interfaces,Functional sites (cofactor),Cofactor binding site,Loss of disulfide bridge,Predicted de-novo disulfide bridge,AlphaFold2 model pLDDT score,AlphaFold2 model secondary structure,DeMaSk delta fitness,DeMaSk Shannon entropy,DeMaSk log2 variant frequency,GEMME Score,EVE score,EVE classification (25% Uncertain),AlphaMissense pathogenicity score,AlphaMissense classification,popEVE score,popEVE status,References +W91A,NP_000537:p.Trp91Ala,,,,,saturation_mutlist,,,,,,,,,,0.13449,0.6592806577682495,2.96293,0.1240363939735011,1.54871,0.12926319698675054,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,0.77494,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.2593,2.4818,-4.8073,-1.21393476861276,4.478983322371786e-07,Benign,0.5809,pathogenic,-2.906,available,https://doi.org/10.1101/2022.10.22.513328 +W91C,NP_000537:p.Trp91Cys,,,,,saturation_mutlist,,,,,,,,,,-0.11546,0.3859982490539551,2.46224,0.7162950373268656,1.17339,0.3004175186634328,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,0.81426,0.56166,Neutral,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.2748,2.4818,-20.417,-0.527962776148948,0.0030173190140476,Benign,0.7778,pathogenic,-3.284,available,https://doi.org/10.1101/2022.10.22.513328 +W91D,NP_000537:p.Trp91Asp,,,,,saturation_mutlist,,,,,,,,,,-0.50416,0.7068338990211487,2.54524,-0.0422129895104933,1.02054,-0.2731864947552467,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,0.74746,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.2836,2.4818,-4.8073,-3.06595378250322,0.4361248909836608,Uncertain,0.914,pathogenic,-3.47,available,https://doi.org/10.1101/2022.10.22.513328 +W91E,NP_000537:p.Trp91Glu,,,,,saturation_mutlist,,,,,,,,,,-0.90589,0.7297422289848328,1.93537,-0.0051486463943489,0.51474,-0.4555193231971744,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,-0.21764,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.3069,2.4818,-5.5443,-1.98268418503221,0.0049803233906901,Benign,0.9253,pathogenic,-3.29,available,https://doi.org/10.1101/2022.10.22.513328 +W91F,NP_000537:p.Trp91Phe,,,,,saturation_mutlist,,,,,,,,,,0.25342,0.3253107666969299,0.71327,0.0646166540236198,0.48334499999999997,0.1590183270118099,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,0.05374,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.1156,2.4818,-5.5443,-2.49209955974605,0.0002906692206613,Benign,0.2249,benign,-3.225,available,https://doi.org/10.1101/2022.10.22.513328 +W91G,NP_000537:p.Trp91Gly,,,,,saturation_mutlist,,,,,,,,,,0.16895,0.831397533416748,3.29694,0.3347920206601007,1.7329450000000002,0.2518710103300503,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,0.93244,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.3241,2.4818,-20.417,-3.12913986924445,0.0374753283240779,Benign,0.4171,ambiguous,-3.281,available,https://doi.org/10.1101/2022.10.22.513328 +W91H,NP_000537:p.Trp91His,,,,,saturation_mutlist,,,,,,,,,,-0.10966,0.6215215921401978,2.33741,-0.2848251579827776,1.1138750000000002,-0.19724257899138878,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,0.57642,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.3273,2.4818,-20.417,-1.89129088279009,0.0174748545295643,Benign,0.8558,pathogenic,-3.264,available,https://doi.org/10.1101/2022.10.22.513328 +W91I,NP_000537:p.Trp91Ile,,,,,saturation_mutlist,,,,,,,,,,-0.64872,0.6050363779067993,2.40578,0.1501377374098406,0.87853,-0.24929113129507968,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,-0.17684,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.257,2.4818,-7.1292,-0.784314728700572,0.0002492861200903,Benign,0.5898,pathogenic,-3.165,available,https://doi.org/10.1101/2022.10.22.513328 +W91K,NP_000537:p.Trp91Lys,,,,,saturation_mutlist,,,,,,,,,,0.18895,0.741982638835907,2.79694,0.2457337626371547,1.4929450000000002,0.21734188131857735,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,0.61108,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.327,2.4818,-7.1292,-3.71242629965711,0.0978694955327409,Benign,0.9641,pathogenic,-3.401,available,https://doi.org/10.1101/2022.10.22.513328 +W91L,NP_000537:p.Trp91Leu,,,,,saturation_mutlist,,,,,,,,,,-0.83501,0.472441554069519,1.95544,-0.3514367407681779,0.560215,-0.593223370384089,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,-0.13138,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.2067,2.4818,-4.8073,-0.234824387695313,1.9495371150361774e-06,Benign,0.3707,ambiguous,-2.933,available,https://doi.org/10.1101/2022.10.22.513328 +W91M,NP_000537:p.Trp91Met,,,,,saturation_mutlist,,,,,,,,,,-1.11734,0.5022221207618713,1.75,-0.1563676703299804,0.31633,-0.6368538351649902,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,0.3914,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.2985,2.4818,-20.417,-1.19458907253691,0.0042940757537255,Benign,0.6634,pathogenic,-3.206,available,https://doi.org/10.1101/2022.10.22.513328 +W91N,NP_000537:p.Trp91Asn,,,,,saturation_mutlist,,,,,,,,,,0.11794,0.6729283332824707,2.78367,0.0726495216509226,1.450805,0.0952947608254613,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,1.01732,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.3715,2.4818,-20.417,-1.86691678346054,6.618042871131374e-05,Benign,0.8586,pathogenic,-3.128,available,https://doi.org/10.1101/2022.10.22.513328 +W91P,NP_000537:p.Trp91Pro,,,,,saturation_mutlist,,,,,,,,,,0.16653,0.765921413898468,2.27415,0.4556881770478566,1.22034,0.31110908852392827,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,0.37088,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.33,2.4818,-4.8073,-1.41535491378381,3.004220184257384e-07,Benign,0.6349,pathogenic,-2.849,available,https://doi.org/10.1101/2022.10.22.513328 +W91Q,NP_000537:p.Trp91Gln,,,,,saturation_mutlist,,,,,,,,,,-0.63785,0.7094010710716248,2.18231,0.1809676106037211,0.7722300000000001,-0.22844119469813945,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,0.63264,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.2827,2.4818,-4.8073,-2.27091397558982,0.0004180444582935,Benign,0.9033,pathogenic,-3.074,available,https://doi.org/10.1101/2022.10.22.513328 +W91R,NP_000537:p.Trp91Arg,"hg19,17:g.7579416A>G, hg38,17:g.7676098A>G",,,0.507,"ClinVar,saturation_mutlist",845798,Uncertain significance,1,,,,,,,0.38095,0.6719430685043335,2.89626,0.0779073523943424,1.6386049999999999,0.22942867619717122,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,0.60182,0.18891,Neutral,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.3228,2.4818,-20.417,-3.32436611299892,0.0014634687722784,Benign,0.9346,pathogenic,-3.32,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +W91S,NP_000537:p.Trp91Ser,"hg19,17:g.7579415C>G, hg38,17:g.7676097C>G",,,0.485,"cBioPortal,ClinVar,saturation_mutlist",3232053,Uncertain significance,1,,,,,,,0.18292,0.693004310131073,2.94558,-0.1051575611484884,1.5642500000000001,0.0388812194257558,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,1.15866,1.50205,Destabilizing,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.248,2.4818,-2.9594,-1.25226234139329,6.558056921170282e-06,Benign,0.447,ambiguous,-2.918,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +W91T,NP_000537:p.Trp91Thr,,,,,saturation_mutlist,,,,,,,,,,-0.00995,0.6327381730079651,2.22585,0.1123255355983787,1.10795,0.05118776779918935,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,0.93594,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.2997,2.4818,-4.5443,-1.40011306436101,1.818842508136829e-05,Benign,0.5926,pathogenic,-2.974,available,https://doi.org/10.1101/2022.10.22.513328 +W91V,NP_000537:p.Trp91Val,,,,,saturation_mutlist,,,,,,,,,,0.2113,0.6098564863204956,2.00646,0.1950469609586241,1.10888,0.20317348047931205,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.012,0.38832,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.2385,2.4818,-5.1293,-0.83720437558844,3.584732021346137e-06,Benign,0.4933,ambiguous,-3.016,available,https://doi.org/10.1101/2022.10.22.513328 +W91Y,NP_000537:p.Trp91Tyr,,,,,saturation_mutlist,,,,,,,,,,0.75633,0.3066970109939575,1.50952,0.1316882545163095,1.132925,0.4440091272581547,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,0.14172,,Uncertain,,Uncertain,,,Uncertain,90.3,,True,90.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,57.48,-,-0.1666,2.4818,-6.1292,-1.78688237164843,0.012426577193421,Benign,0.5289,ambiguous,-3.276,available,https://doi.org/10.1101/2022.10.22.513328 +P92A,NP_000537:p.Pro92Ala,"hg38,17:g.7676095G>C",,,0.509,"COSMIC,saturation_mutlist",,,,,,,,,,0.7046,0.3437433242797851,0.51871,-0.2972354048001946,0.6116550000000001,0.2036822975999027,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.14814,-0.25892,Neutral,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.1124,1.3832,-4.9818,-1.1402449252468,2.276109414306165e-06,Benign,0.1419,benign,-2.988,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P92C,NP_000537:p.Pro92Cys,,,,,saturation_mutlist,,,,,,,,,,0.87745,0.1802228093147277,0.86463,0.4965244423493409,0.87104,0.6869872211746704,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.08028,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,58.84,-,-0.2247,1.3832,-20.5915,-3.3239204213933,0.6418164856825995,Uncertain,0.555,ambiguous,-3.741,available,https://doi.org/10.1101/2022.10.22.513328 +P92D,NP_000537:p.Pro92Asp,,,,,saturation_mutlist,,,,,,,,,,0.44447,0.8688455820083618,0.42925,-0.4060462687118071,0.43686,0.019211865644096437,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.10986,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,58.84,-,-0.2506,1.3832,-20.5915,-3.98445845286414,0.0656958959214358,Benign,0.6764,pathogenic,-3.364,available,https://doi.org/10.1101/2022.10.22.513328 +P92E,NP_000537:p.Pro92Glu,,,,,saturation_mutlist,,,,,,,,,,-0.29539,0.649449348449707,0.48844,-0.5113230788121931,0.096525,-0.4033565394060965,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,-0.11958,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.1615,1.3832,-6.3037,-4.48907941538531,0.0315104970744822,Benign,0.492,ambiguous,-3.444,available,https://doi.org/10.1101/2022.10.22.513328 +P92F,NP_000537:p.Pro92Phe,,,,,saturation_mutlist,,,,,,,,,,0.39492,0.497636616230011,1.04354,-0.4329623225786017,0.7192299999999999,-0.019021161289300842,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.21264,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.2531,1.3832,-20.5915,-4.90474620883069,0.2970402818187991,Benign,0.5921,pathogenic,-3.591,available,https://doi.org/10.1101/2022.10.22.513328 +P92G,NP_000537:p.Pro92Gly,,,,,saturation_mutlist,,,,,,,,,,1.25484,0.7154979705810547,1.43741,0.236904116787513,1.346125,0.7458720583937565,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.2219,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.1335,1.3832,-6.3037,-3.19751384610838,0.0001534020377648,Benign,0.3719,ambiguous,-3.173,available,https://doi.org/10.1101/2022.10.22.513328 +P92H,NP_000537:p.Pro92His,"hg19,17:g.7579412G>T, hg38,17:g.7676094G>T",,,0.452,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3634435,Uncertain significance,1,,,,,,,0.35837,0.3927367329597473,0.03878,-0.6906628439438933,0.198575,-0.16614642197194665,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.09728,-0.04375,Neutral,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.2307,1.3832,-20.5915,-3.34022868100625,0.0201685841707549,Benign,0.3065,benign,-3.401,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P92I,NP_000537:p.Pro92Ile,,,,,saturation_mutlist,,,,,,,,,,0.36058,0.2656782865524292,0.76837,-0.5570595987509103,0.5644750000000001,-0.09823979937545513,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.08906,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.2362,1.3832,-20.5915,-3.20023373279528,0.0099517758758106,Benign,0.4249,ambiguous,-3.368,available,https://doi.org/10.1101/2022.10.22.513328 +P92K,NP_000537:p.Pro92Lys,,,,,saturation_mutlist,,,,,,,,,,0.46769,-0.0162912607192993,0.46565,-0.4895908050901781,0.46667000000000003,-0.010950402545089055,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.17684,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.2261,1.3832,-20.5915,-5.12893583928586,0.1132193516459608,Benign,0.5541,ambiguous,-3.464,available,https://doi.org/10.1101/2022.10.22.513328 +P92L,NP_000537:p.Pro92Leu,"hg19,17:g.7579412G>A, hg38,17:g.7676094G>A",,3.9932274862e-06,0.487,"COSMIC,ClinVar,saturation_mutlist",480733,Conflicting classifications of pathogenicity,1,,,,,,,0.36888,0.3156858682632446,0.22177,-0.81392310209015,0.295325,-0.22252155104507498,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.19522,-0.06662,Neutral,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.1678,1.3832,-6.3037,-2.7413727216631,0.0016469770770584,Benign,0.186,benign,-3.211,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P92M,NP_000537:p.Pro92Met,,,,,saturation_mutlist,,,,,,,,,,0.14886,0.2632288336753845,0.59184,-0.4136504343772412,0.37035,-0.1323952171886206,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.06266,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.1239,1.3832,-7.3037,-4.35965628374266,0.0050418113379245,Benign,0.4047,ambiguous,-3.609,available,https://doi.org/10.1101/2022.10.22.513328 +P92N,NP_000537:p.Pro92Asn,,,,,saturation_mutlist,,,,,,,,,,0.4245,0.4929684996604919,0.77619,-0.3337454566611719,0.600345,0.04537727166941405,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.12818,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,58.84,-,-0.2187,1.3832,-20.5915,-4.182541296034,0.0030528099230972,Benign,0.4425,ambiguous,-3.407,available,https://doi.org/10.1101/2022.10.22.513328 +P92Q,NP_000537:p.Pro92Gln,,,,,saturation_mutlist,,,,,,,,,,0.28996,0.282370388507843,0.37347,-0.2218018846057984,0.331715,0.034079057697100804,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.17632,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.1475,1.3832,-6.3037,-3.79800615055763,0.0659039849299627,Benign,0.2507,benign,-3.354,available,https://doi.org/10.1101/2022.10.22.513328 +P92R,NP_000537:p.Pro92Arg,,,,,saturation_mutlist,,,,,,,,,,0.34041,0.0316890478134155,0.52823,-0.6862288947709777,0.43432,-0.17290944738548886,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.11672,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.2618,1.3832,-20.5915,-4.66208450595303,0.0170723778145903,Benign,0.373,ambiguous,-3.45,available,https://doi.org/10.1101/2022.10.22.513328 +P92S,NP_000537:p.Pro92Ser,"hg19,17:g.7579413G>A, hg19,17:g.7676095G>A",,,0.502,"cBioPortal,saturation_mutlist",,,,,,,,,,0.74994,0.4724637866020202,0.5949,-0.2531139580135327,0.67242,0.24841302099323367,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.13824,0.14539,Neutral,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.1239,1.3832,-7.3037,-1.26628204561654,1.6759643091015722e-05,Benign,0.2002,benign,-3.008,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P92T,NP_000537:p.Pro92Thr,"hg19,17:g.7579413G>T, hg38,17:g.7676095G>T",,,0.434,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,,,0.34891,0.4895867705345154,0.79252,-0.3179366760196017,0.570715,0.015486661990199158,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.13592,-0.02908,Neutral,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,58.84,-,-0.1126,1.3832,-2.7188,-0.0844077474009532,1.578833230636274e-08,Benign,0.1425,benign,-2.867,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P92V,NP_000537:p.Pro92Val,,,,,saturation_mutlist,,,,,,,,,,0.76499,0.3771212100982666,0.69184,-0.3970633676070528,0.728415,0.18396331619647358,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.0923,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.1186,1.3832,-6.3037,-2.7433785794869,6.81786700674331e-05,Benign,0.2723,benign,-3.144,available,https://doi.org/10.1101/2022.10.22.513328 +P92W,NP_000537:p.Pro92Trp,,,,,saturation_mutlist,,,,,,,,,,0.51206,0.4178265929222107,1.04762,-0.8270524810996194,0.77984,-0.1574962405498097,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.058,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.2656,1.3832,-20.5915,-4.90474620883069,0.4475317298130224,Uncertain,0.7573,pathogenic,-3.878,available,https://doi.org/10.1101/2022.10.22.513328 +P92Y,NP_000537:p.Pro92Tyr,,,,,saturation_mutlist,,,,,,,,,,0.62702,0.412703275680542,0.80272,-0.4010273758021104,0.71487,0.11299631209894481,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,0.26788,,Uncertain,,Uncertain,,,Uncertain,54.7,,True,54.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,58.84,-,-0.2541,1.3832,-20.5915,-4.37030066074791,0.0137687591080177,Benign,0.6056,pathogenic,-3.614,available,https://doi.org/10.1101/2022.10.22.513328 +L93A,NP_000537:p.Leu93Ala,,,,,saturation_mutlist,,,,,,,,,,0.35916,0.5367840528488159,0.62823,0.7422760067640805,0.493695,0.5507180033820402,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,0.20382,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,61.16,-,-0.1574,2.0195,-7.2945,-1.74360972504892,5.347517750636637e-06,Benign,0.3383,benign,-2.995,available,https://doi.org/10.1101/2022.10.22.513328 +L93C,NP_000537:p.Leu93Cys,,,,,saturation_mutlist,,,,,,,,,,0.56896,0.1773903369903564,1.43639,1.2710887166285716,1.002675,0.9200243583142858,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.22782,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,61.16,-,-0.2145,2.0195,-20.5824,-3.85931423451475,0.23759370335703,Benign,0.6666,pathogenic,-3.554,available,https://doi.org/10.1101/2022.10.22.513328 +L93D,NP_000537:p.Leu93Asp,,,,,saturation_mutlist,,,,,,,,,,0.12471,1.0385557413101196,0.86871,0.6110596272685522,0.49671,0.3678848136342761,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.017,-0.08872,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,61.16,-,-0.3468,2.0195,-20.5824,-3.91833103907657,0.0495214771960732,Benign,0.8585,pathogenic,-3.403,available,https://doi.org/10.1101/2022.10.22.513328 +L93E,NP_000537:p.Leu93Glu,,,,,saturation_mutlist,,,,,,,,,,-0.52787,0.7607153654098511,0.34762,0.3995027401313444,-0.09012499999999998,-0.06418362993432777,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.18868,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,61.16,-,-0.3148,2.0195,-20.5824,-2.68089126047792,0.0008992207912727,Benign,0.6405,pathogenic,-3.208,available,https://doi.org/10.1101/2022.10.22.513328 +L93F,NP_000537:p.Leu93Phe,,,,,saturation_mutlist,,,,,,,,,,-0.02552,0.3620640635490417,0.4466,0.3169777089650527,0.21054,0.14572885448252634,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.35168,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,61.16,-,-0.0726,2.0195,-3.7097,-4.39451215448914,0.4488436240026198,Uncertain,0.2765,benign,-3.474,available,https://doi.org/10.1101/2022.10.22.513328 +L93G,NP_000537:p.Leu93Gly,,,,,saturation_mutlist,,,,,,,,,,0.68621,1.0024607181549072,1.56633,1.475284016160955,1.1262699999999999,1.0807470080804775,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.017,0.20456,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,61.16,-,-0.3001,2.0195,-20.5824,-4.48203356518943,0.0894131889642919,Benign,0.636,pathogenic,-3.395,available,https://doi.org/10.1101/2022.10.22.513328 +L93H,NP_000537:p.Leu93His,,,,,saturation_mutlist,,,,,,,,,,0.50892,0.5056394934654236,0.56361,0.3806124204096583,0.536265,0.4447662102048292,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.02652,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,61.16,-,-0.2676,2.0195,-20.5824,-1.99435145688493,0.0052305032321909,Benign,0.5051,ambiguous,-3.314,available,https://doi.org/10.1101/2022.10.22.513328 +L93I,NP_000537:p.Leu93Ile,,,,,saturation_mutlist,,,,,,,,,,0.18045,-0.479722261428833,0.58537,0.0456715472509061,0.38291,0.11306077362545305,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.67128,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,61.16,-,-0.0264,2.0195,-6.2946,-2.99324817973558,0.0093101687232552,Benign,0.1815,benign,-3.358,available,https://doi.org/10.1101/2022.10.22.513328 +L93K,NP_000537:p.Leu93Lys,,,,,saturation_mutlist,,,,,,,,,,0.397,0.1268020868301391,0.70068,0.6033516428126801,0.54884,0.5001758214063401,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.4121,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,61.16,-,-0.3138,2.0195,-20.5824,-3.74387614296158,0.0977368140255221,Benign,0.6189,pathogenic,-3.435,available,https://doi.org/10.1101/2022.10.22.513328 +L93M,NP_000537:p.Leu93Met,"hg38,17:g.7676092G>T",,,0.369,"COSMIC,saturation_mutlist",,,,,,,,,,0.02457,0.2059362530708313,0.25238,0.4130315368821236,0.138475,0.21880076844106178,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.3163,-0.33263,Neutral,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,61.16,-,-0.1226,2.0195,-20.5824,-3.6612659002697,0.0473841459919966,Benign,0.2185,benign,-3.558,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L93N,NP_000537:p.Leu93Asn,,,,,saturation_mutlist,,,,,,,,,,0.58337,0.6501116752624512,0.62891,0.7251268785871801,0.60614,0.6542484392935901,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.8629,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,61.16,-,-0.2134,2.0195,-4.9727,-2.55070726551275,0.0071121520024584,Benign,0.6043,pathogenic,-3.289,available,https://doi.org/10.1101/2022.10.22.513328 +L93P,NP_000537:p.Leu93Pro,"hg19,17:g.7579409A>G, hg38,17:g.7676091A>G",,,0.454,"cBioPortal,ClinVar,saturation_mutlist",3359424,Uncertain significance,2,,,,,,,-0.57459,0.5103895664215088,-0.08707,1.238337474953416,-0.33083,0.33187373747670795,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.41926,0.38454,Neutral,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,61.16,-,-0.2155,2.0195,-2.3404,-0.972126353393272,1.1769875923835863e-07,Benign,0.2035,benign,-2.848,available,https://doi.org/10.1101/2022.10.22.513328 +L93Q,NP_000537:p.Leu93Gln,"hg38,17:g.7676091A>T",,,0.469,"COSMIC,saturation_mutlist",,,,,,,,,,0.11932,0.4484016299247741,0.09762,0.6416983761420414,0.10847,0.3805091880710207,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.05096,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,61.16,-,-0.246,2.0195,-20.5824,-3.68069507398829,0.0012883170554864,Benign,0.3316,benign,-3.26,available,https://doi.org/10.1101/2022.10.22.513328 +L93R,NP_000537:p.Leu93Arg,"hg19,17:g.7579409A>C, hg38,17:g.7676091A>C",,,0.498,"ClinVar,saturation_mutlist",2825997,Uncertain significance,1,,,,,,,0.40951,0.1381211876869201,0.2483,0.4159500122216381,0.328905,0.412730006110819,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.6258,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,61.16,-,-0.3054,2.0195,-20.5824,-3.67649296587768,0.0549362428711858,Benign,0.4359,ambiguous,-3.362,available,https://doi.org/10.1101/2022.10.22.513328 +L93S,NP_000537:p.Leu93Ser,,,,,saturation_mutlist,,,,,,,,,,0.60795,0.4340790510177612,0.68537,0.8634125209589788,0.64666,0.7356812604794893,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,0.20748,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,61.16,-,-0.1797,2.0195,-5.7096,-1.81498187094926,8.260849118849823e-06,Benign,0.4072,ambiguous,-2.934,available,https://doi.org/10.1101/2022.10.22.513328 +L93T,NP_000537:p.Leu93Thr,,,,,saturation_mutlist,,,,,,,,,,0.46729,-0.0429023504257202,0.81224,0.6137163202118345,0.6397649999999999,0.5405031601059173,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.4946,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,61.16,-,-0.1436,2.0195,-3.9727,-1.10512047812244,8.003061773126843e-09,Benign,0.3346,benign,-2.89,available,https://doi.org/10.1101/2022.10.22.513328 +L93V,NP_000537:p.Leu93Val,"hg19,17:g.7579410G>C",,,0.523,"cBioPortal,saturation_mutlist",,,,,,,,,,0.58786,-0.1904892921447754,0.89014,0.2305376082287147,0.7390000000000001,0.4091988041143574,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.4571,-0.11797,Neutral,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,61.16,-,-0.056,2.0195,-4.9727,-1.6273262742249,0.0003765152340316,Benign,0.1396,benign,-3.157,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L93W,NP_000537:p.Leu93Trp,,,,,saturation_mutlist,,,,,,,,,,0.12688,0.398468554019928,0.73027,0.087563121808451,0.428575,0.1072215609042255,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-1.02308,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,61.16,-,-0.2578,2.0195,-20.5824,-4.39451215448914,0.6057636158494181,Uncertain,0.6015,pathogenic,-3.794,available,https://doi.org/10.1101/2022.10.22.513328 +L93Y,NP_000537:p.Leu93Tyr,,,,,saturation_mutlist,,,,,,,,,,0.25247,0.3864127993583679,0.31122,0.3530718523759291,0.281845,0.30277092618796453,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,-0.0113,,Uncertain,,Uncertain,,,Uncertain,73.5,,True,73.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,61.16,-,-0.2507,2.0195,-20.5824,-3.53915697937206,0.2666488553267249,Benign,0.6637,pathogenic,-3.396,available,https://doi.org/10.1101/2022.10.22.513328 +S94A,NP_000537:p.Ser94Ala,"hg19,17:g.7579407A>C, hg38,17:g.7676089A>C",,,0.476,"ClinVar,saturation_mutlist",3460308,Likely benign,1,,,,,,,-0.42814,0.4017374515533447,-1.12007,-0.0130452329338709,-0.7741049999999999,-0.22059261646693545,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.013,0.00076,,,,,,,,1.1,,True,1.1,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,64.5,-,-0.0586,1.3645,-3.372,-1.56212327402617,1.94384983719918e-05,Benign,0.1502,benign,-3.049,available,https://doi.org/10.1101/2022.10.22.513328 +S94C,NP_000537:p.Ser94Cys,,,,,saturation_mutlist,,,,,,,,,,0.36604,1.0166457891464231,0.81939,0.5146804067921235,0.592715,0.44036020339606174,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,0.00302,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.1249,1.3645,-6.4594,-1.68211249867161,0.0038006281392755,Benign,0.309,benign,-3.411,available,https://doi.org/10.1101/2022.10.22.513328 +S94D,NP_000537:p.Ser94Asp,,,,,saturation_mutlist,,,,,,,,,,1.76425,2.13909912109375,5.12143,1.4165500964930955,3.4428400000000003,1.590400048246548,Uncertain,Neutral,Destabilizing,Destabilizing,Neutral,False,0.013,-0.07264,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.1629,1.3645,-4.4594,-4.0170483131042,0.5272674440374404,Uncertain,0.9271,pathogenic,-3.524,available,https://doi.org/10.1101/2022.10.22.513328 +S94E,NP_000537:p.Ser94Glu,,,,,saturation_mutlist,,,,,,,,,,7.76241,2.1507930755615234,8.22653,1.962869686520028,7.99447,4.862639843260014,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.013,0.02304,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.2192,1.3645,-20.7472,-3.94498980320792,0.150822334273034,Benign,0.9373,pathogenic,-3.628,available,https://doi.org/10.1101/2022.10.22.513328 +S94F,NP_000537:p.Ser94Phe,,,,,saturation_mutlist,,,,,,,,,,14.38762,2.046550750732422,2.58231,1.1764684972936823,8.484965,7.782044248646841,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.013,-0.09056,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.2254,1.3645,-20.7472,-4.57560261069663,0.3222859218220883,Uncertain,0.7408,pathogenic,-3.601,available,https://doi.org/10.1101/2022.10.22.513328 +S94G,NP_000537:p.Ser94Gly,,,,,saturation_mutlist,,,,,,,,,,0.79374,1.3597078323364258,0.78878,1.3143912489999772,0.7912600000000001,1.0540656244999886,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,-0.00916,,,,,,,,1.1,,True,1.1,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,64.5,-,-0.0887,1.3645,-7.4593,-3.76010924502571,0.0388820177233675,Benign,0.3203,benign,-3.296,available,https://doi.org/10.1101/2022.10.22.513328 +S94H,NP_000537:p.Ser94His,,,,,saturation_mutlist,,,,,,,,,,15.14756,1.9895614385604856,6.74082,1.1468126821071878,10.94419,8.147186341053594,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.013,0.0049,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.2266,1.3645,-20.7472,-3.81593281544085,0.149651043026511,Benign,0.8654,pathogenic,-3.56,available,https://doi.org/10.1101/2022.10.22.513328 +S94I,NP_000537:p.Ser94Ile,,,,,saturation_mutlist,,,,,,,,,,1.0893,2.0967061519622803,3.60238,0.9904428124982124,2.34584,1.0398714062491061,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,False,0.013,0.04864,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.2285,1.3645,-20.7472,-3.56475722317723,0.2556552566718552,Benign,0.7723,pathogenic,-3.59,available,https://doi.org/10.1101/2022.10.22.513328 +S94K,NP_000537:p.Ser94Lys,,,,,saturation_mutlist,,,,,,,,,,10.59815,1.974801540374756,5.08333,3.2027692624627613,7.84074,6.900459631231381,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.013,0.04146,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.2359,1.3645,-20.7472,-4.11204179485188,0.1795284700789453,Benign,0.9852,pathogenic,-3.752,available,https://doi.org/10.1101/2022.10.22.513328 +S94L,NP_000537:p.Ser94Leu,"hg19,17:g.7579406G>A, hg38,17:g.7676088G>A",,,0.553,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1796426,Likely benign,1,,,,,,,2.39711,2.343092203140259,4.8119,0.9637638555827084,3.6045049999999996,1.6804369277913542,Uncertain,Uncertain,Destabilizing,Destabilizing,Neutral,False,0.013,0.00696,-0.01434,Neutral,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.2248,1.3645,-20.7472,-3.70352067652373,0.0730685594066265,Benign,0.418,ambiguous,-3.407,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S94M,NP_000537:p.Ser94Met,,,,,saturation_mutlist,,,,,,,,,,4.80899,1.6762075424194336,2.67075,1.040035051543899,3.73987,2.9245125257719495,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.013,0.03774,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.1958,1.3645,-20.7472,-3.59355822842575,0.1845266982563653,Benign,0.6504,pathogenic,-3.602,available,https://doi.org/10.1101/2022.10.22.513328 +S94N,NP_000537:p.Ser94Asn,,,,,saturation_mutlist,,,,,,,,,,3.39249,2.0041253566741943,3.23639,0.7898474209520625,3.3144400000000003,2.0911687104760315,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.013,0.01448,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.1696,1.3645,-20.7472,-3.89067554066391,0.2340316492730176,Benign,0.7584,pathogenic,-3.505,available,https://doi.org/10.1101/2022.10.22.513328 +S94P,NP_000537:p.Ser94Pro,"hg38,17:g.7676089A>G",,,0.528,"COSMIC,saturation_mutlist",,,,,,,,,,0.15892,2.1758065223693848,2.57177,3.8822319802200727,1.365345,2.020575990110036,Uncertain,Uncertain,Destabilizing,Neutral,Uncertain,False,0.013,0.07774,-0.36023,Neutral,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.3008,1.3645,-20.7472,-3.4641723347253,0.0519329135204096,Benign,0.3757,ambiguous,-3.272,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S94Q,NP_000537:p.Ser94Gln,,,,,saturation_mutlist,,,,,,,,,,7.60139,1.715293288230896,4.94014,1.6270349934447783,6.270765000000001,4.61421249672239,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.013,0.07394,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.1892,1.3645,-20.7472,-3.81098517197492,0.2129047108591134,Benign,0.898,pathogenic,-3.428,available,https://doi.org/10.1101/2022.10.22.513328 +S94R,NP_000537:p.Ser94Arg,,,,,saturation_mutlist,,,,,,,,,,13.11708,1.809463381767273,5.14184,2.347624265764369,9.12946,7.732352132882184,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.013,0.00548,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.2412,1.3645,-20.7472,-5.006526004605,0.367506146511582,Uncertain,0.9766,pathogenic,-3.711,available,https://doi.org/10.1101/2022.10.22.513328 +S94T,NP_000537:p.Ser94Thr,"hg19,17:g.7579407A>T, hg38,17:g.7676089A>T",,,0.533,"COSMIC,ClinVar,saturation_mutlist",3634434,Uncertain significance,1,,,,,,,0.84075,0.9167637825012208,0.1898,0.720277372237251,0.515275,0.7805136861186255,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.013,0.01208,0.03912,Neutral,,,,,,1.1,,True,1.1,,neutral,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.0474,1.3645,-3.0,-1.25737220118974,1.7053555002961567e-08,Benign,0.1639,benign,-2.99,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S94V,NP_000537:p.Ser94Val,,,,,saturation_mutlist,,,,,,,,,,0.79721,1.869112730026245,1.20578,0.2520407482784048,1.001495,0.5246253741392024,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,0.01372,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.2028,1.3645,-20.7472,-2.95005419863415,0.3308457305355405,Uncertain,0.6211,pathogenic,-3.512,available,https://doi.org/10.1101/2022.10.22.513328 +S94W,NP_000537:p.Ser94Trp,,,,,saturation_mutlist,,,,,,,,,,25.00286,1.826282620429993,5.18027,1.6405956240874746,15.091565,13.321727812043736,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.013,-0.16026,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.2351,1.3645,-20.7472,-4.93180911905865,0.790329777694893,Pathogenic,0.8429,pathogenic,-3.93,available,https://doi.org/10.1101/2022.10.22.513328 +S94Y,NP_000537:p.Ser94Tyr,,,,,saturation_mutlist,,,,,,,,,,16.57626,2.148725271224976,4.42143,1.49117679572786,10.498845000000001,9.03371839786393,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.013,-0.10982,,,,,,,,1.1,,True,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,64.5,-,-0.2302,1.3645,-20.7472,-4.93180911905865,0.5990972720667167,Uncertain,0.7639,pathogenic,-3.758,available,https://doi.org/10.1101/2022.10.22.513328 +S95A,NP_000537:p.Ser95Ala,,,,,saturation_mutlist,,,,,,,,,,-0.21678,0.0600934028625488,0.21905,-0.3275205131232883,0.0011349999999999971,-0.27215025656164415,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,60.79,S,-0.0608,1.4458,-5.263,-1.71627596163644,0.0001944473850016,Benign,0.1129,benign,-3.242,available,https://doi.org/10.1101/2022.10.22.513328 +S95C,NP_000537:p.Ser95Cys,,,,,saturation_mutlist,,,,,,,,,,-0.00037,-0.0214616656303405,0.61667,0.6346812322551861,0.30815000000000003,0.3171556161275931,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.1232,1.4458,-7.5849,-1.86625679685849,0.0012638791501257,Benign,0.1946,benign,-3.33,available,https://doi.org/10.1101/2022.10.22.513328 +S95D,NP_000537:p.Ser95Asp,,,,,saturation_mutlist,,,,,,,,,,-0.15056,0.2235326170921325,0.67313,-0.2886414221650901,0.261285,-0.21960071108254503,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.2443,1.4458,-21.8727,-4.48921668319848,0.3742817151648986,Uncertain,0.9294,pathogenic,-3.657,available,https://doi.org/10.1101/2022.10.22.513328 +S95E,NP_000537:p.Ser95Glu,,,,,saturation_mutlist,,,,,,,,,,-0.2054,0.2191089391708374,0.38605,-0.4179440288024416,0.090325,-0.3116720144012208,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.2175,1.4458,-21.8727,-3.55089874691538,0.5546601439377166,Uncertain,0.9511,pathogenic,-3.854,available,https://doi.org/10.1101/2022.10.22.513328 +S95F,NP_000537:p.Ser95Phe,"hg19,17:g.7579403G>A, hg19,17:g.7676085G>A, hg38,17:g.7676085G>A",,,0.751,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1796813,Uncertain significance,2,,,,,,,-0.00479,0.3607861995697021,0.1102,-0.4797205455741277,0.052705,-0.24225527278706385,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.1558,1.4458,-8.5848,-4.7110723281636,0.20821639503736,Benign,0.5749,pathogenic,-3.619,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S95G,NP_000537:p.Ser95Gly,,,,,saturation_mutlist,,,,,,,,,,-0.05049,0.2683102488517761,0.82653,0.2550866868011953,0.38802,0.10229834340059764,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.0869,1.4458,-8.5848,-3.67023605996198,0.043884283362602,Benign,0.2855,benign,-3.407,available,https://doi.org/10.1101/2022.10.22.513328 +S95H,NP_000537:p.Ser95His,,,,,saturation_mutlist,,,,,,,,,,0.20969,0.2914421558380127,0.03027,-0.5648485634764083,0.11997999999999999,-0.17757928173820417,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.2249,1.4458,-21.8727,-4.4650546267409,0.8231434215473808,Pathogenic,0.8547,pathogenic,-3.706,available,https://doi.org/10.1101/2022.10.22.513328 +S95I,NP_000537:p.Ser95Ile,,,,,saturation_mutlist,,,,,,,,,,-0.04703,0.3000758290290832,0.58095,-0.3718008110114446,0.26696,-0.2094154055057223,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.2268,1.4458,-21.8727,-4.83432270971047,0.5077313907029326,Uncertain,0.7491,pathogenic,-3.694,available,https://doi.org/10.1101/2022.10.22.513328 +S95K,NP_000537:p.Ser95Lys,,,,,saturation_mutlist,,,,,,,,,,-0.68733,0.1293877959251403,-0.1051,-0.4203833560012349,-0.396215,-0.5538566780006174,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.2342,1.4458,-21.8727,-5.85970868158159,0.7232675333413295,Pathogenic,0.9885,pathogenic,-3.788,available,https://doi.org/10.1101/2022.10.22.513328 +S95L,NP_000537:p.Ser95Leu,,,,,saturation_mutlist,,,,,,,,,,-0.4562,0.2747736573219299,-0.31701,-0.7952945128655214,-0.386605,-0.6257472564327607,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.223,1.4458,-21.8727,-3.3327467737705,0.2033369136338462,Benign,0.4096,ambiguous,-3.546,available,https://doi.org/10.1101/2022.10.22.513328 +S95M,NP_000537:p.Ser95Met,,,,,saturation_mutlist,,,,,,,,,,-0.72229,0.3067161440849304,-0.02041,-0.4427684930284126,-0.37135,-0.5825292465142062,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.1941,1.4458,-21.8727,-4.78839393439237,0.4440665153345293,Uncertain,0.6351,pathogenic,-3.834,available,https://doi.org/10.1101/2022.10.22.513328 +S95N,NP_000537:p.Ser95Asn,,,,,saturation_mutlist,,,,,,,,,,0.04462,0.2481964826583862,-0.01531,-0.2537211538683442,0.014655,-0.10455057693417211,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.1679,1.4458,-21.8727,-3.99569220537374,0.2333324876406342,Benign,0.753,pathogenic,-3.534,available,https://doi.org/10.1101/2022.10.22.513328 +S95P,NP_000537:p.Ser95Pro,,,,,saturation_mutlist,,,,,,,,,,-1.61026,-0.2509483098983764,1.04728,0.8745370292571244,-0.28149,-0.3678614853714378,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.1919,1.4458,-0.8845,-1.29624277371681,0.0002128928392532,Benign,0.3471,ambiguous,-3.057,available,https://doi.org/10.1101/2022.10.22.513328 +S95Q,NP_000537:p.Ser95Gln,,,,,saturation_mutlist,,,,,,,,,,-0.42088,0.1398866176605224,-0.0898,-0.2248236932162972,-0.25534,-0.3228518466081486,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.1875,1.4458,-21.8727,-3.93035616761955,0.2174235054896063,Benign,0.9124,pathogenic,-3.514,available,https://doi.org/10.1101/2022.10.22.513328 +S95R,NP_000537:p.Ser95Arg,,,,,saturation_mutlist,,,,,,,,,,-0.53693,0.2570775151252746,0.06395,-0.5489640018912489,-0.23649,-0.5429470009456245,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.2395,1.4458,-21.8727,-5.85970868158159,0.6022650920964228,Uncertain,0.9791,pathogenic,-3.708,available,https://doi.org/10.1101/2022.10.22.513328 +S95T,NP_000537:p.Ser95Thr,"hg19,17:g.7579404A>T, hg19,17:g.7676086A>T, hg38,17:g.7676086A>T",,,0.584,"cBioPortal,ClinVar,saturation_mutlist",4189261,Likely benign,1,,,,,,,0.02129,0.1343470215797424,-0.04966,-0.230138838639709,-0.014185000000000001,-0.1044244193198545,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,neutral,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.0468,1.4458,-4.337,-2.06507932473082,0.0032512674269952,Benign,0.208,benign,-3.226,available,https://doi.org/10.1101/2022.10.22.513328 +S95V,NP_000537:p.Ser95Val,,,,,saturation_mutlist,,,,,,,,,,0.01336,0.2164293527603149,0.47075,-0.148829592793071,0.242055,-0.0677347963965355,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.201,1.4458,-21.8727,-4.13720708242182,0.1205819576314009,Benign,0.554,ambiguous,-3.528,available,https://doi.org/10.1101/2022.10.22.513328 +S95W,NP_000537:p.Ser95Trp,,,,,saturation_mutlist,,,,,,,,,,-0.12549,0.3379155993461609,-0.16259,-0.9578516517643398,-0.14404,-0.5416708258821699,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.2333,1.4458,-21.8727,-5.04761796011238,0.7898209021894601,Pathogenic,0.794,pathogenic,-3.957,available,https://doi.org/10.1101/2022.10.22.513328 +S95Y,NP_000537:p.Ser95Tyr,,,,,saturation_mutlist,,,,,,,,,,0.03441,0.4084890484809875,-0.02687,-0.4169748151976765,0.0037700000000000008,-0.19128240759883824,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,113.1,,True,113.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,60.79,S,-0.2285,1.4458,-21.8727,-5.04761796011238,0.5262064675961159,Uncertain,0.6561,pathogenic,-3.802,available,https://doi.org/10.1101/2022.10.22.513328 +S96A,NP_000537:p.Ser96Ala,,,,,saturation_mutlist,,,,,,,,,,-0.03965,0.3050501346588135,-0.20476,0.0404686713679908,-0.122205,0.00040933568399540224,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,87.3,-,0.0071,1.939,-0.8554,-1.35742066572025,3.056026280851333e-08,Benign,0.0705,benign,-2.907,available,https://doi.org/10.1101/2022.10.22.513328 +S96C,NP_000537:p.Ser96Cys,"hg38,17:g.7676082G>C",,,0.497,"COSMIC,saturation_mutlist",,,,,,,,,,-0.13646,-0.2624785304069519,0.27517,0.7643510873174938,0.06935500000000001,0.3139455436587469,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.0779,1.939,-7.6036,-0.34128869387561,0.0001236835924297,Benign,0.0735,benign,-3.399,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S96D,NP_000537:p.Ser96Asp,,,,,saturation_mutlist,,,,,,,,,,-0.25236,0.4397062957286834,-0.20102,0.1095510091006979,-0.22669,-0.07140449544965104,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.1231,1.939,-7.0186,-3.68180297665221,0.0021579427427872,Benign,0.7525,pathogenic,-3.256,available,https://doi.org/10.1101/2022.10.22.513328 +S96E,NP_000537:p.Ser96Glu,,,,,saturation_mutlist,,,,,,,,,,-0.61101,-0.0173152685165405,-0.06122,-0.182391301408259,-0.33611500000000005,-0.3967006507041295,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.1722,1.939,-21.8913,-4.09869736106783,0.0111628043353425,Benign,0.7954,pathogenic,-3.285,available,https://doi.org/10.1101/2022.10.22.513328 +S96F,NP_000537:p.Ser96Phe,"hg19,17:g.7579400G>A, hg38,17:g.7676082G>A",,,0.401,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,,,-1.24458,-0.1232432723045349,-0.50476,-0.5280816476704936,-0.8746700000000001,-0.8863308238352468,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.0875,1.939,-4.0801,-1.07794336160378,1.9314864756330438e-07,Benign,0.1005,benign,-2.986,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S96G,NP_000537:p.Ser96Gly,,,,,saturation_mutlist,,,,,,,,,,0.39822,0.8027030229568481,0.66224,0.7501387643291704,0.53023,0.5741793821645852,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,87.3,-,-0.1095,1.939,-21.8913,-3.51019663724948,0.0892098936224562,Benign,0.185,benign,-3.356,available,https://doi.org/10.1101/2022.10.22.513328 +S96H,NP_000537:p.Ser96His,,,,,saturation_mutlist,,,,,,,,,,-0.2138,0.052060067653656,-0.49558,-0.2540561334819552,-0.35469,-0.2339280667409776,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.1796,1.939,-21.8913,-3.26675595591615,0.0010630626498775,Benign,0.5035,ambiguous,-3.27,available,https://doi.org/10.1101/2022.10.22.513328 +S96I,NP_000537:p.Ser96Ile,,,,,saturation_mutlist,,,,,,,,,,-0.92743,-0.1203965544700622,0.78333,-0.5502534972102047,-0.07205,-0.7388417486051023,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.1086,1.939,-7.6036,-1.74151289994249,3.371691239113086e-06,Benign,0.2336,benign,-3.109,available,https://doi.org/10.1101/2022.10.22.513328 +S96K,NP_000537:p.Ser96Lys,,,,,saturation_mutlist,,,,,,,,,,-0.90639,0.3094292283058166,0.01565,-0.1314670815390506,-0.44537,-0.5189285407695253,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.1889,1.939,-21.8913,-4.75464975243647,0.0109219295614495,Benign,0.9203,pathogenic,-3.409,available,https://doi.org/10.1101/2022.10.22.513328 +S96L,NP_000537:p.Ser96Leu,,,,,saturation_mutlist,,,,,,,,,,-0.94319,0.187573492527008,0.06769,-0.7034034213147977,-0.43775,-0.8232967106573988,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.1099,1.939,-8.6035,-2.22608306694327,0.0001893663082115,Benign,0.1676,benign,-3.084,available,https://doi.org/10.1101/2022.10.22.513328 +S96M,NP_000537:p.Ser96Met,,,,,saturation_mutlist,,,,,,,,,,-1.20402,0.1610658764839172,0.18469,-0.1066302053614892,-0.509665,-0.6553251026807446,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.1488,1.939,-21.8913,-2.20697817288065,0.0025671382305458,Benign,0.2261,benign,-3.435,available,https://doi.org/10.1101/2022.10.22.513328 +S96N,NP_000537:p.Ser96Asn,,,,,saturation_mutlist,,,,,,,,,,-0.10322,0.2500143647193908,-0.00204,0.1691889530362439,-0.05263,0.03298447651812195,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.1226,1.939,-21.8913,-3.65748934132842,0.0005777655663437,Benign,0.3709,ambiguous,-3.28,available,https://doi.org/10.1101/2022.10.22.513328 +S96P,NP_000537:p.Ser96Pro,"hg38,17:g.7676083A>G",,,0.522,"COSMIC,saturation_mutlist",,,,,,,,,,0.66873,1.7109124660491943,6.02109,2.633673838282862,3.34491,1.651201919141431,Uncertain,Uncertain,Uncertain,Destabilizing,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.1859,1.939,-8.6035,-3.03071754527268,0.000172308026415,Benign,0.3417,ambiguous,-3.026,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S96Q,NP_000537:p.Ser96Gln,,,,,saturation_mutlist,,,,,,,,,,-0.53724,0.2051675915718078,-0.14898,0.1438778230661391,-0.34311,-0.19668108846693047,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.0744,1.939,-8.6035,-3.32547661459157,0.0024126576651134,Benign,0.6892,pathogenic,-3.173,available,https://doi.org/10.1101/2022.10.22.513328 +S96R,NP_000537:p.Ser96Arg,,,,,saturation_mutlist,,,,,,,,,,-0.6259,0.2249202132225036,0.26395,-0.2903032701759028,-0.180975,-0.45810163508795143,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.1942,1.939,-21.8913,-4.9800209563858,0.0176212877479234,Benign,0.8655,pathogenic,-3.421,available,https://doi.org/10.1101/2022.10.22.513328 +S96T,NP_000537:p.Ser96Thr,,,,,saturation_mutlist,,,,,,,,,,-0.49272,-0.2814385294914245,0.26599,-0.0006663538645229,-0.113365,-0.24669317693226145,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,neutral,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,0.0072,1.939,-2.6494,-0.700155032396655,1.1320891300419807e-10,Benign,0.0875,benign,-2.854,available,https://doi.org/10.1101/2022.10.22.513328 +S96V,NP_000537:p.Ser96Val,,,,,saturation_mutlist,,,,,,,,,,-0.51033,-0.2221651673316955,0.72925,-0.3881401915309551,0.10946,-0.4492350957654775,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.0685,1.939,-4.7963,-1.76296523696745,2.1694227449796813e-07,Benign,0.1595,benign,-2.954,available,https://doi.org/10.1101/2022.10.22.513328 +S96W,NP_000537:p.Ser96Trp,,,,,saturation_mutlist,,,,,,,,,,-1.38169,-0.0010163187980651,-0.53299,-0.8947501085562015,-0.9573400000000001,-1.1382200542781007,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.1881,1.939,-21.8913,-4.01761161957871,0.1998227197069803,Benign,0.2772,benign,-3.693,available,https://doi.org/10.1101/2022.10.22.513328 +S96Y,NP_000537:p.Ser96Tyr,"hg19,17:g.7579400G>T, hg38,17:g.7676082G>T",,,0.565,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,,,-1.59365,-0.099770188331604,-0.7898,-0.4271792055147816,-1.191725,-1.0104146027573908,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,70.7,,True,70.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,87.3,-,-0.1832,1.939,-21.8913,-4.01761161957871,0.0022393541400475,Benign,0.176,benign,-3.524,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V97A,NP_000537:p.Val97Ala,"hg19,17:g.7579397A>G, hg38,17:g.7676079A>G",,,0.854,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1797574,Uncertain significance,1,,,,,,,1.25505,1.4196722507476809,2.07993,1.904053297722732,1.66749,1.579551648861366,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.252,1.0688,-22.1111,-5.36511122484401,0.5487273833264157,Uncertain,0.9394,pathogenic,-3.551,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V97C,NP_000537:p.Val97Cys,,,,,saturation_mutlist,,,,,,,,,,0.67299,0.9172980189323424,1.66701,1.9447965657363533,1.17,1.3088932828681767,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.2799,1.0688,-22.1111,-5.17028542499567,0.7643564927010076,Pathogenic,0.9708,pathogenic,-3.83,available,https://doi.org/10.1101/2022.10.22.513328 +V97D,NP_000537:p.Val97Asp,"hg19,17:g.7579397A>T, hg19,17:g.7676079A>T, hg38,17:g.7676079A>T",,,0.937,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182924,Uncertain significance,2,,,,,,,1.09786,2.09325647354126,1.97483,2.0708016363951,1.536345,1.5843308181975502,Neutral,Uncertain,Destabilizing,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.4186,1.0688,-22.1111,-5.76966537956288,0.8367362934207128,Pathogenic,0.9926,pathogenic,-3.869,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V97E,NP_000537:p.Val97Glu,,,,,saturation_mutlist,,,,,,,,,,1.12967,1.7500531673431396,2.11054,1.639492371266403,1.620105,1.3845811856332015,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,91.9,-,-0.3759,1.0688,-22.1111,-5.87735687108478,0.7959459747562792,Pathogenic,0.9841,pathogenic,-3.796,available,https://doi.org/10.1101/2022.10.22.513328 +V97F,NP_000537:p.Val97Phe,"hg19,17:g.7579398C>A, hg38,17:g.7676080C>A",,,0.789,"cBioPortal,ClinVar,saturation_mutlist",458532,Conflicting classifications of pathogenicity,1,,,,,,,1.04993,1.210354566574097,1.52109,0.9589462056941436,1.28551,1.0044381028470717,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.2532,1.0688,-7.2384,-4.01003087254825,0.1053264402537229,Benign,0.7555,pathogenic,-3.327,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V97G,NP_000537:p.Val97Gly,,,,,saturation_mutlist,,,,,,,,,,2.05789,2.130985736846924,3.56905,3.2104505023589858,2.8134699999999997,2.634170251179493,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.3778,1.0688,-22.1111,-6.7913130174839,0.591603801522253,Uncertain,0.9574,pathogenic,-3.794,available,https://doi.org/10.1101/2022.10.22.513328 +V97H,NP_000537:p.Val97His,,,,,saturation_mutlist,,,,,,,,,,1.56793,1.66990864276886,3.5881,1.4182961747063132,2.5780149999999997,1.4931130873531566,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.3486,1.0688,-7.8233,-5.66962079249705,0.7114590992447591,Pathogenic,0.99,pathogenic,-3.742,available,https://doi.org/10.1101/2022.10.22.513328 +V97I,NP_000537:p.Val97Ile,"hg19,17:g.7579398C>T, hg38,17:g.7676080C>T",,0.0,0.593,"COSMIC,ClinVar,saturation_mutlist",1026336,Uncertain significance,2,,,,,,,-0.52021,-0.0491449832916259,-0.27687,0.0715315879880162,-0.39854,-0.2243392060059919,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.078,1.0688,-0.6585,-0.624748642106392,0.0004660953253299,Benign,0.1238,benign,-3.056,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V97K,NP_000537:p.Val97Lys,,,,,saturation_mutlist,,,,,,,,,,0.6039,1.6935616731643677,1.86905,1.4968302969296203,1.236475,1.0503651484648102,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.4148,1.0688,-22.1111,-6.7913130174839,0.8133161677525892,Pathogenic,0.9895,pathogenic,-4.034,available,https://doi.org/10.1101/2022.10.22.513328 +V97L,NP_000537:p.Val97Leu,"hg19,17:g.7579398C>G, hg38,17:g.7676080C>G",,,0.701,"ClinVar,saturation_mutlist",182962,Conflicting classifications of pathogenicity,1,,,,,,,-0.59058,0.7027922868728638,1.61395,0.42746602367075,0.511685,-0.081556988164625,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.1848,1.0688,-8.8232,-2.50386002494792,0.0926601665621832,Benign,0.7885,pathogenic,-3.232,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V97M,NP_000537:p.Val97Met,,,,,saturation_mutlist,,,,,,,,,,-0.44163,1.1067291498184204,2.07857,0.9898962007913812,0.81847,0.2741331003956906,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.2617,1.0688,-22.1111,-3.33503200257337,0.387817101079041,Uncertain,0.8026,pathogenic,-3.552,available,https://doi.org/10.1101/2022.10.22.513328 +V97N,NP_000537:p.Val97Asn,,,,,saturation_mutlist,,,,,,,,,,0.81472,1.977313041687012,1.20986,1.7638812025572173,1.01229,1.2893006012786086,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.4064,1.0688,-22.1111,-5.21586743816459,0.3122894778429866,Benign,0.9755,pathogenic,-3.703,available,https://doi.org/10.1101/2022.10.22.513328 +V97P,NP_000537:p.Val97Pro,,,,,saturation_mutlist,,,,,,,,,,0.49712,1.890754222869873,1.91259,2.746040690794836,1.204855,1.621580345397418,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.4563,1.0688,-22.1111,-6.7913130174839,0.6776574615506201,Uncertain,0.9644,pathogenic,-3.582,available,https://doi.org/10.1101/2022.10.22.513328 +V97Q,NP_000537:p.Val97Gln,,,,,saturation_mutlist,,,,,,,,,,0.47354,1.6444867849349976,2.51429,1.5512137344920955,1.4939149999999999,1.0123768672460478,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,91.9,-,-0.3865,1.0688,-22.1111,-5.87735687108478,0.6209002658328524,Uncertain,0.9779,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328 +V97R,NP_000537:p.Val97Arg,,,,,saturation_mutlist,,,,,,,,,,0.9997,1.612048864364624,1.75034,1.1496287507532923,1.3750200000000001,1.074664375376646,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.4358,1.0688,-22.1111,-6.7913130174839,0.7193581657987287,Pathogenic,0.9743,pathogenic,-3.885,available,https://doi.org/10.1101/2022.10.22.513328 +V97S,NP_000537:p.Val97Ser,,,,,saturation_mutlist,,,,,,,,,,1.93243,1.588980197906494,2.20136,2.1524210998571336,2.066895,2.042425549928567,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.3556,1.0688,-22.1111,-5.20799796771757,0.2389210977172926,Benign,0.9384,pathogenic,-3.55,available,https://doi.org/10.1101/2022.10.22.513328 +V97T,NP_000537:p.Val97Thr,,,,,saturation_mutlist,,,,,,,,,,1.00563,0.6925755739212036,1.19218,1.384378605065394,1.098905,1.195004302532697,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.271,1.0688,-22.1111,-5.61453514890981,0.7653631194740931,Pathogenic,0.9119,pathogenic,-3.72,available,https://doi.org/10.1101/2022.10.22.513328 +V97W,NP_000537:p.Val97Trp,,,,,saturation_mutlist,,,,,,,,,,1.08917,1.2310066223144531,2.09422,0.8154761385937831,1.591695,0.9523230692968916,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.3697,1.0688,-22.1111,-5.89863134919257,0.8591654982273584,Pathogenic,0.9928,pathogenic,-4.002,available,https://doi.org/10.1101/2022.10.22.513328 +V97Y,NP_000537:p.Val97Tyr,,,,,saturation_mutlist,,,,,,,,,,1.01003,1.2216825485229492,1.31088,1.1153077876430275,1.160455,1.0626688938215136,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,29.0,,False,29.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,91.9,-,-0.3048,1.0688,-8.8232,-5.89863134919257,0.4040249311190922,Uncertain,0.9762,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328 +P98A,NP_000537:p.Pro98Ala,"hg19,17:g.7579395G>C, hg38,17:g.7676077G>C",,,0.935,"ClinVar,saturation_mutlist",1039474,Uncertain significance,2,,,,,,,2.43221,0.6629639267921448,0.87619,0.8082243651308474,1.6542,1.6202171825654237,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.3233,0.0409,-22.1143,-7.42683667603059,0.8543805855773687,Pathogenic,0.9289,pathogenic,-4.01,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98C,NP_000537:p.Pro98Cys,,,,,saturation_mutlist,,,,,,,,,,2.24878,0.3627352714538574,1.44116,1.514892107411923,1.84497,1.8818360537059615,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.67,-,-0.356,0.0409,-22.1143,-7.42683667603059,0.8705056719051573,Pathogenic,0.9931,pathogenic,-4.181,available,https://doi.org/10.1101/2022.10.22.513328 +P98D,NP_000537:p.Pro98Asp,,,,,saturation_mutlist,,,,,,,,,,2.00931,1.2214025259017944,2.64626,1.52734547117414,2.327785,1.7683277355870701,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.67,-,-0.3819,0.0409,-22.1143,-6.84653774232336,0.8167415408671135,Pathogenic,0.9994,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328 +P98E,NP_000537:p.Pro98Glu,,,,,saturation_mutlist,,,,,,,,,,1.23492,0.6483156681060791,0.18129,1.18592754615022,0.708105,1.21042377307511,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.3657,0.0409,-22.1143,-6.6768897355542,0.7405995680697558,Pathogenic,0.9979,pathogenic,-4.106,available,https://doi.org/10.1101/2022.10.22.513328 +P98F,NP_000537:p.Pro98Phe,"hg38,17:g.7676076_7676077delinsAA",,,,"COSMIC,saturation_mutlist",,,,,,,,,,0.50288,0.7742148637771606,1.83299,0.0033146573579606,1.167935,0.25309732867898027,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.3844,0.0409,-22.1143,-6.84653774232336,0.8694766006891228,Pathogenic,0.9973,pathogenic,-4.214,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98G,NP_000537:p.Pro98Gly,,,,,saturation_mutlist,,,,,,,,,,3.39528,1.167629957199097,2.45646,2.3888222534384487,2.9258699999999997,2.8920511267192244,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.3376,0.0409,-22.1143,-7.42683667603059,0.8606228671379441,Pathogenic,0.9947,pathogenic,-4.171,available,https://doi.org/10.1101/2022.10.22.513328 +P98H,NP_000537:p.Pro98His,"hg19,17:g.7579394G>T",,,0.953,"cBioPortal,saturation_mutlist",,,,,,,,,,1.49598,1.246808409690857,1.3568,0.5082057325598773,1.42639,1.0020928662799387,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.362,0.0409,-22.1143,-6.34933447998002,0.6613095857805996,Uncertain,0.9956,pathogenic,-3.911,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98I,NP_000537:p.Pro98Ile,,,,,saturation_mutlist,,,,,,,,,,0.44574,0.6139539480209351,-0.03061,-0.5054327544399045,0.207565,-0.029846377219952258,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.3674,0.0409,-22.1143,-4.21603750481885,0.2977200543052704,Benign,0.9759,pathogenic,-3.803,available,https://doi.org/10.1101/2022.10.22.513328 +P98K,NP_000537:p.Pro98Lys,,,,,saturation_mutlist,,,,,,,,,,1.93732,1.4284113645553589,1.66088,1.3816735005583085,1.7991,1.6594967502791542,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.3574,0.0409,-22.1143,-7.1769155286079,0.870847769499351,Pathogenic,0.9984,pathogenic,-4.282,available,https://doi.org/10.1101/2022.10.22.513328 +P98L,NP_000537:p.Pro98Leu,"hg19,17:g.7579394G>A, hg19,17:g.7676076G>A, hg38,17:g.7676076G>A",,3.9800361387e-06,0.943,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528236,Conflicting classifications of pathogenicity,1,,,,,,,0.62102,0.574503481388092,-0.18435,-0.6687947719664561,0.218335,-0.023887385983228038,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.2991,0.0409,-7.8265,-3.6959843729838,0.0020796179803121,Benign,0.9328,pathogenic,-3.484,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98M,NP_000537:p.Pro98Met,,,,,saturation_mutlist,,,,,,,,,,0.02772,0.5442750453948975,0.0949,-0.0456682383928358,0.06131,-0.008974119196417898,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.323,0.0409,-22.1143,-5.97545587041913,0.7827002118195212,Pathogenic,0.9929,pathogenic,-4.135,available,https://doi.org/10.1101/2022.10.22.513328 +P98N,NP_000537:p.Pro98Asn,,,,,saturation_mutlist,,,,,,,,,,2.10004,1.320141077041626,1.45272,1.048467954335968,1.77638,1.574253977167984,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.67,-,-0.35,0.0409,-22.1143,-6.84653774232336,0.85224232949847,Pathogenic,0.9989,pathogenic,-4.085,available,https://doi.org/10.1101/2022.10.22.513328 +P98Q,NP_000537:p.Pro98Gln,,,,,saturation_mutlist,,,,,,,,,,1.77034,1.1783108711242676,-1.26088,0.7901502970236179,0.25473,1.280245148511809,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.3517,0.0409,-22.1143,-6.69160345532609,0.4893438202432831,Uncertain,0.9956,pathogenic,-3.853,available,https://doi.org/10.1101/2022.10.22.513328 +P98R,NP_000537:p.Pro98Arg,"hg19,17:g.7579394G>C, hg38,17:g.7676076G>C",,,0.955,"ClinVar,saturation_mutlist",1444043,Uncertain significance,2,,,,,,,2.28701,1.4521080255508425,1.82347,0.6117466632248658,2.05524,1.449378331612433,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.3931,0.0409,-22.1143,-6.74972083521465,0.8555864794873003,Pathogenic,0.9928,pathogenic,-4.085,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98S,NP_000537:p.Pro98Ser,"hg19,17:g.7579395G>A, hg19,17:g.7579395_7579396delinsAA, hg19,17:g.7676077G>A, hg38,17:g.7676077G>A, hg38,17:g.7676077_7676078delinsAA",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",822279,Uncertain significance,2,,,,,,,3.09634,0.9757696390151978,1.53435,1.3799766455099471,2.315345,2.2381583227549737,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.323,0.0409,-22.1143,-7.42683667603059,0.6184060215368166,Uncertain,0.9911,pathogenic,-3.766,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98T,NP_000537:p.Pro98Thr,"hg19,17:g.7579395G>T, hg38,17:g.7676077G>T",,,0.957,"COSMIC,ClinVar,saturation_mutlist",1465351,Uncertain significance,1,,,,,,,1.15357,1.1110941171646118,1.34184,0.8710312827021943,1.2477049999999998,1.012300641351097,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.67,-,-0.3351,0.0409,-22.1143,-7.42683667603059,0.7727350216441489,Pathogenic,0.9793,pathogenic,-3.927,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P98V,NP_000537:p.Pro98Val,,,,,saturation_mutlist,,,,,,,,,,1.43703,0.7789857983589172,1.02381,-0.1141654995955571,1.23042,0.6614322502022215,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.3228,0.0409,-22.1143,-5.07190444507632,0.2041897478568988,Benign,0.9425,pathogenic,-3.734,available,https://doi.org/10.1101/2022.10.22.513328 +P98W,NP_000537:p.Pro98Trp,,,,,saturation_mutlist,,,,,,,,,,1.34916,0.7531998157501221,0.64422,-0.1595492816847593,0.99669,0.5948053591576203,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.3969,0.0409,-22.1143,-6.84653774232336,0.8582450526562,Pathogenic,0.999,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +P98Y,NP_000537:p.Pro98Tyr,,,,,saturation_mutlist,,,,,,,,,,1.58129,0.7491486072540283,1.57313,0.3977399367022627,1.57721,0.9895149683511314,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,30.2,,False,30.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.67,-,-0.3854,0.0409,-22.1143,-6.84653774232336,0.8249436729842745,Pathogenic,0.9982,pathogenic,-4.174,available,https://doi.org/10.1101/2022.10.22.513328 +S99A,NP_000537:p.Ser99Ala,,,,,saturation_mutlist,,,,,,,,,,0.18453,1.0176851749420166,0.11224,0.2704468681710942,0.148385,0.2274884340855471,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,-,uncertain,neutral,False,neutral,neutral,94.32,-,-0.1339,0.8482,-8.8168,-2.03662347596349,0.0021624643995575,Benign,0.1293,benign,-3.26,available,https://doi.org/10.1101/2022.10.22.513328 +S99C,NP_000537:p.Ser99Cys,"hg19,17:g.7579391G>C, hg38,17:g.7676073G>C",,,0.729,"ClinVar,saturation_mutlist",566954,Uncertain significance,1,,,,,,,-0.01687,0.8087365627288818,1.36769,0.8748467561061715,0.6754100000000001,0.4289883780530857,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.1793,0.8482,-7.8169,-2.10999191868723,0.0592506188520818,Benign,0.1223,benign,-3.364,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S99D,NP_000537:p.Ser99Asp,,,,,saturation_mutlist,,,,,,,,,,-1.63052,0.4179534912109375,-0.31701,-0.0899913763296189,-0.973765,-0.8602556881648095,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.3004,0.8482,-22.1047,-4.99000117418982,0.4866656516797909,Uncertain,0.9326,pathogenic,-3.761,available,https://doi.org/10.1101/2022.10.22.513328 +S99E,NP_000537:p.Ser99Glu,,,,,saturation_mutlist,,,,,,,,,,-0.92176,1.192246913909912,0.05238,0.0434937823832054,-0.43469,-0.4391331088083973,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.1956,0.8482,-6.817,-3.24842132571137,0.0764739357484207,Benign,0.9424,pathogenic,-3.504,available,https://doi.org/10.1101/2022.10.22.513328 +S99F,NP_000537:p.Ser99Phe,"hg19,17:g.7579391G>A, hg38,17:g.7676073G>A",,,0.748,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",579376,Uncertain significance,1,,,,,,,-0.32293,1.602656364440918,0.76054,0.0974664541852798,0.218805,-0.1127317729073601,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.212,0.8482,-8.8168,-4.37964932676007,0.4768589392004329,Uncertain,0.7366,pathogenic,-3.593,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S99G,NP_000537:p.Ser99Gly,,,,,saturation_mutlist,,,,,,,,,,0.36565,1.1265369653701782,1.47211,0.9390502855788436,0.91888,0.6523501427894218,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.2109,0.8482,-22.1047,-5.29168757840173,0.2486192389644271,Benign,0.3498,ambiguous,-3.646,available,https://doi.org/10.1101/2022.10.22.513328 +S99H,NP_000537:p.Ser99His,,,,,saturation_mutlist,,,,,,,,,,0.41812,1.483330488204956,0.8585,-0.0908225762282277,0.63831,0.16364871188588614,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.281,0.8482,-22.1047,-5.94757588828271,0.7705282874957041,Pathogenic,0.8773,pathogenic,-3.852,available,https://doi.org/10.1101/2022.10.22.513328 +S99I,NP_000537:p.Ser99Ile,,,,,saturation_mutlist,,,,,,,,,,0.072,1.561002492904663,0.59014,0.1272969520183087,0.33107,0.09964847600915436,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.207,0.8482,-7.232,-2.51138486296729,0.0365380203993881,Benign,0.5937,pathogenic,-3.462,available,https://doi.org/10.1101/2022.10.22.513328 +S99K,NP_000537:p.Ser99Lys,,,,,saturation_mutlist,,,,,,,,,,-0.03026,1.6323598623275757,0.15748,0.2801321268804607,0.06361,0.12493606344023034,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.2904,0.8482,-22.1047,-6.07159955555084,0.6238491921797358,Uncertain,0.99,pathogenic,-3.782,available,https://doi.org/10.1101/2022.10.22.513328 +S99L,NP_000537:p.Ser99Leu,,,,,saturation_mutlist,,,,,,,,,,-0.20064,1.5640690326690674,-0.16395,-0.0594957560447051,-0.182295,-0.13006787802235256,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.2792,0.8482,-22.1047,-4.6524473906565,0.3152760368332274,Benign,0.3848,ambiguous,-3.654,available,https://doi.org/10.1101/2022.10.22.513328 +S99M,NP_000537:p.Ser99Met,,,,,saturation_mutlist,,,,,,,,,,-0.33405,1.370009422302246,0.15986,0.2353292562175996,-0.087095,-0.04936037189120021,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.2503,0.8482,-22.1047,-4.6524473906565,0.6108603232935785,Uncertain,0.6321,pathogenic,-3.876,available,https://doi.org/10.1101/2022.10.22.513328 +S99N,NP_000537:p.Ser99Asn,,,,,saturation_mutlist,,,,,,,,,,-0.22005,0.6543265581130981,0.35238,0.051842601850659,0.06616500000000002,-0.0841036990746705,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.1562,0.8482,-8.8168,-2.15050162545049,0.0412081491495104,Benign,0.6939,pathogenic,-3.624,available,https://doi.org/10.1101/2022.10.22.513328 +S99P,NP_000537:p.Ser99Pro,"hg38,17:g.7676074A>G",,,0.730,"COSMIC,saturation_mutlist",,,,,,,,,,-0.40606,1.4720075130462646,0.19388,1.18287212124006,-0.10608999999999999,0.38840606062002997,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.2793,0.8482,-7.232,-3.58565861016749,0.004222359358517,Benign,0.4968,ambiguous,-3.298,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S99Q,NP_000537:p.Ser99Gln,,,,,saturation_mutlist,,,,,,,,,,7e-05,1.4410128593444824,-0.1466,0.3552452161590574,-0.07326500000000001,0.1776576080795287,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.2437,0.8482,-22.1047,-5.3245344443721,0.8169297351414572,Pathogenic,0.9232,pathogenic,-3.706,available,https://doi.org/10.1101/2022.10.22.513328 +S99R,NP_000537:p.Ser99Arg,,,,,saturation_mutlist,,,,,,,,,,0.20209,1.632889747619629,0.98673,0.1092277145249959,0.59441,0.15565885726249795,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.2956,0.8482,-22.1047,-6.07159955555084,0.5342846203214724,Uncertain,0.9759,pathogenic,-3.811,available,https://doi.org/10.1101/2022.10.22.513328 +S99T,NP_000537:p.Ser99Thr,,,,,saturation_mutlist,,,,,,,,,,0.34822,0.7140030860900879,0.07245,0.2816903938755866,0.210335,0.3149551969377933,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,neutral,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.107,0.8482,-5.3575,-1.68878551671982,0.0002817515312688,Benign,0.2426,benign,-3.098,available,https://doi.org/10.1101/2022.10.22.513328 +S99V,NP_000537:p.Ser99Val,,,,,saturation_mutlist,,,,,,,,,,0.38348,1.6692025661468506,-0.06395,0.1666668719955105,0.159765,0.27507343599775524,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.1632,0.8482,-3.6877,-2.56319182008455,0.0001888167233907,Benign,0.4336,ambiguous,-3.176,available,https://doi.org/10.1101/2022.10.22.513328 +S99W,NP_000537:p.Ser99Trp,,,,,saturation_mutlist,,,,,,,,,,0.07592,1.530188798904419,0.85,-0.226098161092656,0.46296,-0.07508908054632801,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,damaging,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.2895,0.8482,-22.1047,-5.94757588828271,0.8504665046761357,Pathogenic,0.8337,pathogenic,-3.997,available,https://doi.org/10.1101/2022.10.22.513328 +S99Y,NP_000537:p.Ser99Tyr,,,,,saturation_mutlist,,,,,,,,,,0.31765,1.8764809370040887,0.50476,0.1438642114846022,0.411205,0.2307571057423011,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.013,,,Uncertain,,Uncertain,,,Uncertain,59.9,P,False,59.9,-0.477,uncertain,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,94.32,-,-0.2846,0.8482,-22.1047,-5.94757588828271,0.764746975734436,Pathogenic,0.7584,pathogenic,-3.759,available,https://doi.org/10.1101/2022.10.22.513328 +Q100A,NP_000537:p.Gln100Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.08526,0.1341677904129028,1.26429,0.3722351759837167,0.6747749999999999,0.22874758799185835,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.13,-,-0.0681,1.6191,-6.0096,-2.18617788994892,5.692926200753552e-05,Benign,0.1818,benign,-3.076,available,https://doi.org/10.1101/2022.10.22.513328 +Q100C,NP_000537:p.Gln100Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.46087,0.0598686933517456,0.93469,0.715528514156813,0.6977800000000001,0.5881992570784065,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.13,-,-0.1964,1.6191,-22.1047,-2.88359836349613,0.2089232186451173,Benign,0.6333,pathogenic,-3.406,available,https://doi.org/10.1101/2022.10.22.513328 +Q100D,NP_000537:p.Gln100Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.06051,0.3773154616355896,0.50748,0.7474288111497496,0.283995,0.40396940557487476,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.13,-,-0.2368,1.6191,-22.1047,-3.61352347944445,0.0160879456823056,Benign,0.5576,ambiguous,-3.404,available,https://doi.org/10.1101/2022.10.22.513328 +Q100E,NP_000537:p.Gln100Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.00722,0.5100064277648926,0.92075,0.5373776997906851,0.463985,0.27229884989534253,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.13,-,-0.0875,1.6191,-8.8168,-0.717685804355302,0.1871007659875273,Benign,0.1196,benign,-3.386,available,https://doi.org/10.1101/2022.10.22.513328 +Q100F,NP_000537:p.Gln100Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.35874,0.3748499155044555,-1.03707,-0.0845257284196093,-0.697905,-0.22163286420980466,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.13,-,-0.2045,1.6191,-22.1047,-5.32766260795124,0.2126188911746656,Benign,0.74,pathogenic,-3.447,available,https://doi.org/10.1101/2022.10.22.513328 +Q100G,NP_000537:p.Gln100Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.80677,0.6489018201828003,1.69762,1.3048475689097303,1.252195,1.0558087844548651,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.13,-,-0.2209,1.6191,-22.1047,-6.16409717367653,0.2567840028423017,Benign,0.258,benign,-3.484,available,https://doi.org/10.1101/2022.10.22.513328 +Q100H,NP_000537:p.Gln100His,"hg38,17:g.7676069C>G",,,0.417,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,0.33238,0.197813868522644,-0.3119,0.0682591749788741,0.010239999999999999,0.20031958748943707,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.13,-,-0.0754,1.6191,-7.232,-2.00345320419082,0.0089012761372089,Benign,0.2951,benign,-3.194,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q100I,NP_000537:p.Gln100Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.79882,0.187441349029541,0.47891,-0.0297159226463378,-0.15995499999999999,-0.4142679613231689,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.13,-,-0.1129,1.6191,-7.8169,-3.42875722247119,4.14873840206641e-06,Benign,0.4695,ambiguous,-3.174,available,https://doi.org/10.1101/2022.10.22.513328 +Q100K,NP_000537:p.Gln100Lys,"hg38,17:g.7676071G>T",,,0.541,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,-0.29817,0.3900784850120544,1.23946,0.4549468733039585,0.470645,0.07838843665197925,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.13,-,-0.1834,1.6191,-22.1047,-4.73372398165281,0.0139138946762343,Benign,0.2262,benign,-3.368,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q100L,NP_000537:p.Gln100Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.70035,0.3720749020576477,-0.65238,-0.1170013498100841,-0.676365,-0.4086756749050421,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.13,-,-0.1692,1.6191,-22.1047,-4.64850701981391,0.0005393629436839,Benign,0.1766,benign,-3.162,available,https://doi.org/10.1101/2022.10.22.513328 +Q100M,NP_000537:p.Gln100Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-1.07397,0.2298858761787414,0.32347,0.1823281260943404,-0.3752500000000001,-0.44582093695282987,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.13,-,-0.1401,1.6191,-22.1047,-4.64770521564569,0.0458879245734926,Benign,0.3977,ambiguous,-3.415,available,https://doi.org/10.1101/2022.10.22.513328 +Q100N,NP_000537:p.Gln100Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.17059,0.4725377559661865,0.03673,0.3783837640681253,0.10366,0.27448688203406263,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.13,-,-0.0566,1.6191,-0.6826,-2.21247686266912,0.0003023702975909,Benign,0.3288,benign,-3.028,available,https://doi.org/10.1101/2022.10.22.513328 +Q100P,NP_000537:p.Gln100Pro,"hg19,17:g.7579388T>G, hg38,17:g.7676070T>G",,,0.398,"ClinVar,saturation_mutlist",4189274,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),,-0.9255,0.9099655747413636,0.92109,1.634704017804696,-0.0022050000000000125,0.35460200890234805,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.13,-,-0.2417,1.6191,-6.0096,-1.80610282178611,0.0011713282289131,Benign,0.0763,benign,-3.077,available,https://doi.org/10.1101/2022.10.22.513328 +Q100R,NP_000537:p.Gln100Arg,,,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,-0.28177,0.387826919555664,0.06122,0.0716010927396121,-0.11027500000000001,-0.10508445363019396,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.13,-,-0.1819,1.6191,-22.1047,-2.23543971919887,0.0024610908094535,Benign,0.2143,benign,-3.19,available,https://doi.org/10.1101/2022.10.22.513328 +Q100S,NP_000537:p.Gln100Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.67818,0.0483473539352417,1.02891,0.5396801381128565,0.853545,0.6089300690564283,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.13,-,-0.0957,1.6191,-7.8169,-2.49194687406266,0.0003890251057128,Benign,0.2055,benign,-3.058,available,https://doi.org/10.1101/2022.10.22.513328 +Q100T,NP_000537:p.Gln100Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.05129,0.006044328212738,0.15102,0.2528567037372226,0.101155,0.1520733518686113,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.13,-,-0.0784,1.6191,-2.4771,-2.13481567354687,4.663829191095043e-10,Benign,0.1739,benign,-2.857,available,https://doi.org/10.1101/2022.10.22.513328 +Q100V,NP_000537:p.Gln100Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.32318,0.0985032320022583,0.50612,-0.0366546025302039,0.09147,-0.17991730126510197,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.13,-,-0.1859,1.6191,-22.1047,-3.58944580318533,0.0005653868532804,Benign,0.2841,benign,-3.252,available,https://doi.org/10.1101/2022.10.22.513328 +Q100W,NP_000537:p.Gln100Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.72862,0.2168110609054565,-0.60816,-0.1769866824195182,-0.66839,-0.4528033412097591,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.13,-,-0.2038,1.6191,-22.1047,-5.32766260795124,0.4138929597883934,Uncertain,0.6625,pathogenic,-3.876,available,https://doi.org/10.1101/2022.10.22.513328 +Q100Y,NP_000537:p.Gln100Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.33184,0.3019396066665649,-0.45578,-0.02470453311883,-0.39381,-0.178272266559415,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.012,,,Uncertain,,Uncertain,,,Uncertain,51.5,,False,51.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.13,-,-0.1389,1.6191,-8.8168,-2.17950936958216,0.0120768242374196,Benign,0.5987,pathogenic,-3.457,available,https://doi.org/10.1101/2022.10.22.513328 +K101A,NP_000537:p.Lys101Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.30693,-0.0639179944992065,-0.22857,0.1359728034377427,0.03917999999999999,0.22145140171887134,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.0938,1.5495,-5.3575,-1.41278294242254,0.0002667008494202,Benign,0.2711,benign,-3.176,available,https://doi.org/10.1101/2022.10.22.513328 +K101C,NP_000537:p.Lys101Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.46604,-0.2756532430648803,0.23299,0.9132370803260732,0.349515,0.6896385401630366,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.2494,1.5495,-22.1047,-2.83150142223143,0.1442606411477681,Benign,0.5815,pathogenic,-3.543,available,https://doi.org/10.1101/2022.10.22.513328 +K101D,NP_000537:p.Lys101Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.98922,-0.1386207938194275,0.15714,0.1851016084395945,-0.41603999999999997,-0.40205919578020277,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.2153,1.5495,-7.8169,-1.78334157833635,0.0004086659020461,Benign,0.3363,benign,-3.175,available,https://doi.org/10.1101/2022.10.22.513328 +K101E,NP_000537:p.Lys101Glu,"hg19,17:g.7579386T>C, hg38,17:g.7676068T>C",,,0.503,"ClinVar,saturation_mutlist",1059163,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),,-0.5532,-0.3748661279678345,0.04116,-0.0788910949402638,-0.25602,-0.3160455474701319,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.1136,1.5495,-4.3576,-1.55515076737838,1.027068838582233e-08,Benign,0.1266,benign,-2.931,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K101F,NP_000537:p.Lys101Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.13556,0.0699501633644104,0.27347,-0.0237324164815549,0.204515,0.05591379175922256,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.2503,1.5495,-22.1047,-5.044545139671,0.1296852828997438,Benign,0.743,pathogenic,-3.638,available,https://doi.org/10.1101/2022.10.22.513328 +K101G,NP_000537:p.Lys101Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.49603,0.4619821608066559,0.57381,0.9180338482342572,0.5349200000000001,0.7070319241171286,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.2384,1.5495,-22.1047,-5.044545139671,0.0630054781695485,Benign,0.3471,ambiguous,-3.56,available,https://doi.org/10.1101/2022.10.22.513328 +K101H,NP_000537:p.Lys101His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.25664,-0.0455291271209716,0.41395,-0.0270687364903315,0.335295,0.11478563175483424,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.1893,1.5495,-22.1047,-5.044545139671,0.0754695084933959,Benign,0.2362,benign,-3.54,available,https://doi.org/10.1101/2022.10.22.513328 +K101I,NP_000537:p.Lys101Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.22548,-0.0843836665153503,0.18401,-0.3210215122571591,0.204745,-0.04777075612857953,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.4,-,-0.1447,1.5495,-7.8169,-2.45659022353884,0.0086048836997251,Benign,0.385,ambiguous,-3.468,available,https://doi.org/10.1101/2022.10.22.513328 +K101L,NP_000537:p.Lys101Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.32874,-0.1233476400375366,0.2119,-0.3700424803246538,0.27032,-0.020651240162326917,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.4,-,-0.2163,1.5495,-22.1047,-3.87081682865391,0.1795284700789453,Benign,0.3431,ambiguous,-3.452,available,https://doi.org/10.1101/2022.10.22.513328 +K101M,NP_000537:p.Lys101Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.09458,-0.0329397320747375,0.42075,-0.0171825852332324,0.25766500000000003,0.038698707383383796,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.1893,1.5495,-22.1047,-4.03369521027091,0.1757486407318587,Benign,0.2284,benign,-3.671,available,https://doi.org/10.1101/2022.10.22.513328 +K101N,NP_000537:p.Lys101Asn,"hg19,17:g.7579384T>A, hg38,17:g.7676066T>A",,,0.340,"COSMIC,ClinVar,saturation_mutlist",237947,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),,0.038,-0.0079248547554016,0.39218,0.1903929441288782,0.21508999999999998,0.1141964720644391,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.1154,1.5495,-6.0096,-0.423504332481986,3.157969582789918e-05,Benign,0.2094,benign,-3.058,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K101P,NP_000537:p.Lys101Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.63667,1.6054649353027344,2.51973,2.125665677913762,1.5782,1.381167838956881,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.3535,1.5495,-22.1047,-5.044545139671,0.5014651435306501,Uncertain,0.7863,pathogenic,-3.428,available,https://doi.org/10.1101/2022.10.22.513328 +K101Q,NP_000537:p.Lys101Gln,"hg19,17:g.7579386T>G, hg38,17:g.7676068T>G",,,0.496,"ClinVar,saturation_mutlist",649735,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),,-0.01045,-0.1610503792762756,-0.82585,0.2196339366202587,-0.41814999999999997,0.10459196831012936,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.1107,1.5495,-8.8168,-3.04929158452359,2.8260505481364628e-05,Benign,0.1082,benign,-3.09,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K101R,NP_000537:p.Lys101Arg,"hg38,17:g.7676067T>C",,,0.533,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,0.13162,-0.0401018857955932,-0.01905,-0.02135624290102,0.056284999999999995,0.05513187854948999,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.4,-,-0.045,1.5495,-8.8168,-2.01201884746741,0.1010940881032756,Benign,0.0904,benign,-3.376,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K101S,NP_000537:p.Lys101Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.5051,-0.021351158618927,-0.16871,0.3968969490996082,0.16819499999999998,0.45099847454980413,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.0995,1.5495,-4.4951,-0.919910715457033,7.994847169645615e-07,Benign,0.2764,benign,-2.957,available,https://doi.org/10.1101/2022.10.22.513328 +K101T,NP_000537:p.Lys101Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.57573,-0.1578888893127441,-0.27347,0.1971125919594479,0.15113,0.38642129597972397,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.0911,1.5495,-0.527,0.228672834758593,8.761507881911952e-07,Benign,0.1361,benign,-2.942,available,https://doi.org/10.1101/2022.10.22.513328 +K101V,NP_000537:p.Lys101Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.61743,-0.1772176027297973,-0.27211,-0.139735096231775,0.17266,0.23884745188411252,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.1336,1.5495,-8.8168,-3.3297754018702,0.0009384157504541,Benign,0.319,benign,-3.332,available,https://doi.org/10.1101/2022.10.22.513328 +K101W,NP_000537:p.Lys101Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.31787,0.0166494250297546,-0.25374,-0.3840274663281884,-0.285805,-0.3509487331640942,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.2594,1.5495,-22.1047,-5.044545139671,0.440194706840784,Uncertain,0.7555,pathogenic,-3.843,available,https://doi.org/10.1101/2022.10.22.513328 +K101Y,NP_000537:p.Lys101Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.18414,0.0459316372871398,-0.06701,0.0095824175892145,0.058565,0.09686120879460725,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,,,Uncertain,,Uncertain,,,Uncertain,93.3,,False,93.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.4,-,-0.2352,1.5495,-22.1047,-5.044545139671,0.1473266006431107,Benign,0.5537,ambiguous,-3.654,available,https://doi.org/10.1101/2022.10.22.513328 +T102A,NP_000537:p.Thr102Ala,"hg19,17:g.7579383T>C, hg38,17:g.7676065T>C",,,0.540,"cBioPortal,ClinVar,saturation_mutlist",1799231,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),,0.0915,-0.188510775566101,0.33435,0.1396909653469791,0.21292499999999998,0.11559548267348956,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,DOWN,neutral,neutral,False,neutral,neutral,97.18,-,-0.1776,0.7787,-7.8201,-2.53667362556609,4.601691309706785e-07,Benign,0.081,benign,-3.329,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T102C,NP_000537:p.Thr102Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.17418,-0.4073922038078308,0.35408,0.6100307732606919,0.26413,0.39210538663034594,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,DOWN,neutral,neutral,False,neutral,neutral,97.18,-,-0.2863,0.7787,-22.1079,-3.72957941007573,0.0077913507551721,Benign,0.3096,benign,-3.487,available,https://doi.org/10.1101/2022.10.22.513328 +T102D,NP_000537:p.Thr102Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.28874,-0.2973073124885559,0.06871,0.2301206292283558,0.178725,0.25943031461417787,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.18,-,-0.2546,0.7787,-0.2772,-0.29341417681953,4.0300179181996736e-11,Benign,0.2173,benign,-2.924,available,https://doi.org/10.1101/2022.10.22.513328 +T102E,NP_000537:p.Thr102Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.55202,0.0287218689918518,-0.6102,-0.0658673309951635,-0.58111,-0.30894366549758173,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.18,-,-0.2736,0.7787,-8.82,-0.77448022992341,8.95023489345923e-08,Benign,0.2262,benign,-3.13,available,https://doi.org/10.1101/2022.10.22.513328 +T102F,NP_000537:p.Thr102Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.02601,-0.302529513835907,-0.45272,-0.4716938280204047,-0.21335500000000002,-0.22284191401020237,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.18,-,-0.3577,0.7787,-22.1079,-6.11400723156905,0.1995774092976594,Benign,0.2724,benign,-3.732,available,https://doi.org/10.1101/2022.10.22.513328 +T102G,NP_000537:p.Thr102Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.80208,0.1531679034233093,1.23503,1.0888216256876226,1.018555,0.9454508128438113,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,DOWN,neutral,neutral,False,neutral,neutral,97.18,-,-0.324,0.7787,-22.1079,-5.49924079322158,0.0077352815111896,Benign,0.1999,benign,-3.49,available,https://doi.org/10.1101/2022.10.22.513328 +T102H,NP_000537:p.Thr102His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.46153,-0.4277469515800476,-0.34524,-0.2500011059899826,-0.403385,-0.3557655529949913,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.18,-,-0.338,0.7787,-22.1079,-6.11400723156905,0.1590434294872293,Benign,0.2253,benign,-3.608,available,https://doi.org/10.1101/2022.10.22.513328 +T102I,NP_000537:p.Thr102Ile,"hg19,17:g.7579382G>A, hg38,17:g.7676064G>A",,,0.540,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",186132,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),,-0.25163,0.0501123368740081,-0.58299,-0.7429690653336135,-0.41731,-0.49729953266680677,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.18,-,-0.2086,0.7787,-8.82,-1.7672563726994,0.0002468585807571,Benign,0.1692,benign,-3.451,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T102K,NP_000537:p.Thr102Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.51139,-0.1400451064109802,0.3415,-0.0671994007882109,-0.08494499999999999,-0.28929470039410543,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.18,-,-0.3336,0.7787,-22.1079,-4.6592805094973,0.0037484607755643,Benign,0.2343,benign,-3.519,available,https://doi.org/10.1101/2022.10.22.513328 +T102L,NP_000537:p.Thr102Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.87095,0.0029852390289306,-0.54626,-0.7119394422023045,-0.7086049999999999,-0.7914447211011523,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.18,-,-0.3283,0.7787,-22.1079,-4.78595872436852,0.0077956004825543,Benign,0.1239,benign,-3.571,available,https://doi.org/10.1101/2022.10.22.513328 +T102M,NP_000537:p.Thr102Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.59528,0.1093597114086151,-0.22653,-0.1985788857460074,-0.410905,-0.3969294428730037,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.18,-,-0.2952,0.7787,-22.1079,-5.23266764577074,0.1261336774472302,Benign,0.1054,benign,-3.736,available,https://doi.org/10.1101/2022.10.22.513328 +T102N,NP_000537:p.Thr102Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.54642,-0.4999206662178039,0.0381,0.053110132609751,0.29226,0.2997650663048755,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.18,-,-0.2332,0.7787,-7.8201,-1.68059276447804,3.99930289927053e-08,Benign,0.0839,benign,-3.058,available,https://doi.org/10.1101/2022.10.22.513328 +T102P,NP_000537:p.Thr102Pro,"hg38,17:g.7676065T>G",,,0.542,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,-1.27722,-0.3041507601737976,-0.28027,0.5106846575928089,-0.778745,-0.38326767120359556,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.18,-,-0.347,0.7787,-8.82,-1.84925043894037,0.0003812711018513,Benign,0.076,benign,-3.216,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T102Q,NP_000537:p.Thr102Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.40435,0.0555084645748138,-0.02041,0.0646972070934265,-0.21237999999999999,-0.16982639645328673,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.18,-,-0.3156,0.7787,-22.1079,-2.83482515028166,0.0043069565385371,Benign,0.2215,benign,-3.378,available,https://doi.org/10.1101/2022.10.22.513328 +T102R,NP_000537:p.Thr102Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.36026,-0.1823805570602417,0.5085,-0.32692158694343,0.07411999999999996,-0.343590793471715,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.18,-,-0.3364,0.7787,-22.1079,-5.42088161049316,0.0101975091220079,Benign,0.1907,benign,-3.625,available,https://doi.org/10.1101/2022.10.22.513328 +T102S,NP_000537:p.Thr102Ser,"hg19,17:g.7579383T>A, hg38,17:g.7676065T>A",,,0.506,"COSMIC,ClinVar,saturation_mutlist",582041,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),,0.54432,-0.2776068449020386,0.47075,0.3058206434689237,0.5075350000000001,0.42507032173446185,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,,,DOWN,neutral,neutral,False,neutral,neutral,97.18,-,-0.2142,0.7787,-22.1079,-3.36761345082637,0.0003386386021109,Benign,0.0959,benign,-3.202,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T102V,NP_000537:p.Thr102Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.25999,0.0711289942264556,-0.70748,-0.6544680641984568,-0.483735,-0.4572290320992284,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.18,-,-0.2639,0.7787,-22.1079,-4.52719845860018,0.0056103408281058,Benign,0.1517,benign,-3.362,available,https://doi.org/10.1101/2022.10.22.513328 +T102W,NP_000537:p.Thr102Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.11103,-0.4146542549133301,-0.7551,-0.82906499920265,-0.322035,-0.359017499601325,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.18,-,-0.3506,0.7787,-22.1079,-6.11400723156905,0.1610016449517735,Benign,0.5816,pathogenic,-4.022,available,https://doi.org/10.1101/2022.10.22.513328 +T102Y,NP_000537:p.Thr102Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.13522,-0.4036599993705749,-0.50748,-0.3777632387368962,-0.18613000000000002,-0.1212716193684481,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.18,-,-0.3592,0.7787,-22.1079,-6.11400723156905,0.0115111823856887,Benign,0.286,benign,-3.713,available,https://doi.org/10.1101/2022.10.22.513328 +Y103A,NP_000537:p.Tyr103Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.96742,1.1395056247711182,2.30748,1.9297952302818104,1.6374499999999999,1.4486076151409053,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.4339,0.1909,-22.1174,-7.00222762676875,0.7129020162583346,Pathogenic,0.9126,pathogenic,-4.16,available,https://doi.org/10.1101/2022.10.22.513328 +Y103C,NP_000537:p.Tyr103Cys,"hg19,17:g.7579379T>C, hg19,17:g.7676061T>C",,,0.870,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,0.6131,0.3091483116149902,2.2534,1.9895775643434688,1.4332500000000001,1.3013387821717344,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.4045,0.1909,-22.1174,-7.00222762676875,0.2979773745374425,Benign,0.4456,ambiguous,-4.046,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y103D,NP_000537:p.Tyr103Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.12301,0.4509905576705932,1.32211,1.6497376236388828,0.5995499999999999,0.7633638118194414,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.4481,0.1909,-22.1174,-6.75854480397109,0.4002054800686839,Uncertain,0.8976,pathogenic,-4.168,available,https://doi.org/10.1101/2022.10.22.513328 +Y103E,NP_000537:p.Tyr103Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.23895,0.8689932823181152,1.58265,1.6507400817257445,0.9107999999999999,0.9448450408628722,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.4768,0.1909,-22.1174,-6.75854480397109,0.7301728111065655,Pathogenic,0.9587,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328 +Y103F,NP_000537:p.Tyr103Phe,"hg38,17:g.7676061T>A",,,0.775,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,-0.17553,0.0605394840240478,0.33844,0.4947138753219587,0.08145500000000001,0.15959193766097934,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.88,B,-0.1985,0.1909,-7.8297,-0.729552418459478,9.846208839618183e-05,Benign,0.1061,benign,-3.347,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y103G,NP_000537:p.Tyr103Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,2.24404,1.951521158218384,4.11429,2.9805115666531816,3.179165,2.6122757833265906,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.5044,0.1909,-22.1174,-7.2459104495664,0.832857019921432,Pathogenic,0.9121,pathogenic,-4.37,available,https://doi.org/10.1101/2022.10.22.513328 +Y103H,NP_000537:p.Tyr103His,"hg19,17:g.7579380A>G",,,0.870,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,0.78602,0.608200192451477,1.38435,1.1565538965434052,1.085185,0.9712869482717026,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.2585,0.1909,-5.8297,-2.42969434848,0.0015319571692587,Benign,0.4862,ambiguous,-3.426,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y103I,NP_000537:p.Tyr103Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.05722,0.7130215167999268,0.45306,0.9009521048163752,0.25514000000000003,0.47908605240818763,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.4459,0.1909,-22.1174,-5.68468001722731,0.6456420435496886,Uncertain,0.831,pathogenic,-4.138,available,https://doi.org/10.1101/2022.10.22.513328 +Y103K,NP_000537:p.Tyr103Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.22222,1.4406083822250366,2.38163,1.5751528963503914,1.301925,0.8986864481751957,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.5021,0.1909,-22.1174,-7.2459104495664,0.7901760025628769,Pathogenic,0.9736,pathogenic,-4.452,available,https://doi.org/10.1101/2022.10.22.513328 +Y103L,NP_000537:p.Tyr103Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.25675,0.668196439743042,1.14116,0.6330518369570126,0.44220499999999996,0.18815091847850632,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.423,0.1909,-22.1174,-5.85400116506491,0.4105026359040801,Uncertain,0.8038,pathogenic,-3.969,available,https://doi.org/10.1101/2022.10.22.513328 +Y103M,NP_000537:p.Tyr103Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.54522,0.8292509317398071,1.80136,1.0556883924632554,0.62807,0.2552341962316277,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.3751,0.1909,-22.1174,-5.64638090685081,0.2786541650117003,Benign,0.8703,pathogenic,-4.052,available,https://doi.org/10.1101/2022.10.22.513328 +Y103N,NP_000537:p.Tyr103Asn,"hg19,17:g.7579380A>T",,,0.906,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,0.53662,0.7070959210395813,1.3415,1.3904460774969287,0.93906,0.9635330387484644,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.4271,0.1909,-22.1174,-6.22898701486561,0.6507354763750128,Uncertain,0.7661,pathogenic,-4.121,available,https://doi.org/10.1101/2022.10.22.513328 +Y103P,NP_000537:p.Tyr103Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,6.87566,2.56713604927063,5.58878,5.75666743219015,6.23222,6.316163716095074,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.5581,0.1909,-22.1174,-7.2459104495664,0.8257930979447108,Pathogenic,0.9851,pathogenic,-4.284,available,https://doi.org/10.1101/2022.10.22.513328 +Y103Q,NP_000537:p.Tyr103Gln,"hg19,17:g.7579378_7579380delinsCTG, hg38,17:g.7676060_7676062delinsCTG",,,,"ClinVar,saturation_mutlist",3010803,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),,0.82611,1.1816682815551758,1.89592,1.5413201357889563,1.361015,1.1837150678944781,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.4516,0.1909,-22.1174,-6.75854480397109,0.7517072268343867,Pathogenic,0.9228,pathogenic,-4.211,available,https://doi.org/10.1101/2022.10.22.513328 +Y103R,NP_000537:p.Tyr103Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.73049,1.1538240909576416,2.0602,1.2027277007146795,1.395345,0.9666088503573398,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.4974,0.1909,-22.1174,-7.2459104495664,0.8328124366186256,Pathogenic,0.9142,pathogenic,-4.258,available,https://doi.org/10.1101/2022.10.22.513328 +Y103S,NP_000537:p.Tyr103Ser,"hg19,17:g.7579379T>G, hg38,17:g.7676061T>G",,,0.904,"ClinVar,saturation_mutlist",2729592,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),,0.88855,1.0751550197601318,2.3534,2.30633344884065,1.620975,1.597441724420325,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.4386,0.1909,-22.1174,-7.00222762676875,0.4076309037514859,Uncertain,0.7037,pathogenic,-3.998,available,https://doi.org/10.1101/2022.10.22.513328 +Y103T,NP_000537:p.Tyr103Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.68256,1.163914918899536,1.9085,1.7959902439367537,1.29553,1.2392751219683769,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.4572,0.1909,-22.1174,-7.00222762676875,0.8187826613508747,Pathogenic,0.8908,pathogenic,-4.172,available,https://doi.org/10.1101/2022.10.22.513328 +Y103V,NP_000537:p.Tyr103Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.3566,0.6911231279373169,0.45306,1.1418450983395547,0.40483,0.7492225491697774,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.88,B,-0.4355,0.1909,-22.1174,-5.74202349396744,0.5135225637042313,Uncertain,0.7661,pathogenic,-4.099,available,https://doi.org/10.1101/2022.10.22.513328 +Y103W,NP_000537:p.Tyr103Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.0369,-0.0437818765640258,1.59388,0.2591368527014498,0.77849,0.11111842635072491,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,56.3,,False,56.3,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.88,B,-0.2836,0.1909,-8.8296,-3.38861835976956,0.0610032583010982,Benign,0.2683,benign,-3.79,available,https://doi.org/10.1101/2022.10.22.513328 +Q104A,NP_000537:p.Gln104Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.76754,-0.0915356278419494,0.42755,0.6288457955936022,0.597545,0.698192897796801,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.4,-,-0.0798,1.2981,-2.5228,-1.13893667816556,1.4532343198023712e-15,Benign,0.0982,benign,-2.862,available,https://doi.org/10.1101/2022.10.22.513328 +Q104C,NP_000537:p.Gln104Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.7506,-0.0969037413597107,0.18231,1.1514555443923336,0.466455,0.9510277721961669,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.4,-,-0.1582,1.2981,-8.8264,-1.1898182266111,1.02902400011064e-08,Benign,0.1754,benign,-3.13,available,https://doi.org/10.1101/2022.10.22.513328 +Q104D,NP_000537:p.Gln104Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.50385,0.1796362996101379,0.95578,1.0939642744232494,0.729815,0.7989071372116248,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.4,-,-0.2663,1.2981,-22.1143,-3.29818501640832,2.149665718541949e-09,Benign,0.1777,benign,-3.084,available,https://doi.org/10.1101/2022.10.22.513328 +Q104E,NP_000537:p.Gln104Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.08882,-0.030500590801239,-0.06565,0.7997994278725501,-0.077235,0.35548971393627504,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.4,-,-0.1849,1.2981,-22.1143,-2.96345143409047,1.233183880716386e-13,Benign,0.0752,benign,-2.97,available,https://doi.org/10.1101/2022.10.22.513328 +Q104F,NP_000537:p.Gln104Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.12482,0.3500536382198334,-0.74048,-0.4289123121001459,-0.43265000000000003,-0.276866156050073,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.4,-,-0.234,1.2981,-22.1143,-3.9104237502095,2.8961804074825645e-06,Benign,0.3302,benign,-3.411,available,https://doi.org/10.1101/2022.10.22.513328 +Q104G,NP_000537:p.Gln104Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.86259,0.2512977719306946,1.11973,1.615996655444632,0.9911599999999999,1.239293327722316,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.4,-,-0.1826,1.2981,-8.8264,-2.24427287698304,5.8638200738131e-13,Benign,0.1249,benign,-3.024,available,https://doi.org/10.1101/2022.10.22.513328 +Q104H,NP_000537:p.Gln104His,"hg19,17:g.7579375C>A, hg19,17:g.7676057C>A, hg38,17:g.7676057C>G",,,0.336,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,0.48156,0.105863332748413,-0.52347,0.1147859618002222,-0.020955,0.2981729809001111,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.4,-,-0.0948,1.2981,-5.2416,-0.346936379405604,2.9435802993527174e-11,Benign,0.0754,benign,-2.908,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q104I,NP_000537:p.Gln104Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.65053,0.3182953000068664,-0.15918,0.0524992919464373,0.24567500000000003,0.3515146459732187,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.4,-,-0.2154,1.2981,-22.1143,-4.30103022239613,8.856720545569785e-06,Benign,0.2682,benign,-3.335,available,https://doi.org/10.1101/2022.10.22.513328 +Q104K,NP_000537:p.Gln104Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.05637,0.2321692705154419,-0.07007,0.7226833219729186,-0.006849999999999995,0.3895266609864593,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.4,-,-0.213,1.2981,-22.1143,-4.08621299998927,1.372387526379108e-07,Benign,0.0865,benign,-3.029,available,https://doi.org/10.1101/2022.10.22.513328 +Q104L,NP_000537:p.Gln104Leu,"hg19,17:g.7579376T>A, hg38,17:g.7676058T>A",,,0.520,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",945802,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),,-0.49611,0.3272004127502441,-0.5,-0.2535013928350027,-0.498055,-0.3748056964175014,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.4,-,-0.1309,1.2981,-8.8264,-3.67544421069349,2.3896251726472592e-08,Benign,0.097,benign,-3.047,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q104M,NP_000537:p.Gln104Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.28819,0.2666698098182678,0.17585,0.1339158963734787,-0.05617,-0.07713705181326065,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.4,-,-0.1697,1.2981,-22.1143,-2.86698909392207,8.251818294172312e-09,Benign,0.2587,benign,-3.149,available,https://doi.org/10.1101/2022.10.22.513328 +Q104N,NP_000537:p.Gln104Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.3685,0.2373121380805969,0.28367,0.6946276900341516,0.32608499999999996,0.5315638450170758,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.4,-,-0.1955,1.2981,-22.1143,-3.22168110342398,1.291236349428933e-09,Benign,0.1417,benign,-3.08,available,https://doi.org/10.1101/2022.10.22.513328 +Q104P,NP_000537:p.Gln104Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.51821,-0.3238449692726135,0.16224,1.9955906016342675,-0.17798499999999998,0.7386903008171337,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.4,-,-0.2429,1.2981,-0.4602,0.499057518359793,2.739106371421924e-22,Benign,0.0597,benign,-2.806,available,https://doi.org/10.1101/2022.10.22.513328 +Q104R,NP_000537:p.Gln104Arg,"hg19,17:g.7676058T>C",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,0.1808,0.3542001247406006,0.34354,0.0849751230651529,0.26217,0.13288756153257644,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.4,-,-0.1386,1.2981,-7.8265,-0.783108861350225,4.24964411085832e-09,Benign,0.0671,benign,-3.03,available,https://doi.org/10.1101/2022.10.22.513328 +Q104S,NP_000537:p.Gln104Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.65726,-0.1220334768295288,0.29014,0.9266601787652924,0.4737,0.7919600893826462,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.4,-,-0.1253,1.2981,-7.8265,-0.952433831807965,1.632005229133553e-13,Benign,0.111,benign,-2.896,available,https://doi.org/10.1101/2022.10.22.513328 +Q104T,NP_000537:p.Gln104Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.93861,0.054646611213684,-0.41565,0.669831259096785,0.26148000000000005,0.8042206295483925,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.4,-,-0.2081,1.2981,-22.1143,-2.46000719912689,2.474330420377527e-09,Benign,0.1203,benign,-3.01,available,https://doi.org/10.1101/2022.10.22.513328 +Q104V,NP_000537:p.Gln104Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.85115,0.1984160542488098,-0.26599,0.2180319726438484,0.29257999999999995,0.5345909863219241,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.4,-,-0.1426,1.2981,-7.8265,-2.664640281264,4.951669274902942e-12,Benign,0.1735,benign,-3.066,available,https://doi.org/10.1101/2022.10.22.513328 +Q104W,NP_000537:p.Gln104Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.28585,0.482483297586441,-0.40544,-0.7837118000413429,-0.059795000000000015,-0.24893090002067145,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.4,-,-0.2334,1.2981,-22.1143,-3.9104237502095,2.6223556719387905e-05,Benign,0.2238,benign,-3.606,available,https://doi.org/10.1101/2022.10.22.513328 +Q104Y,NP_000537:p.Gln104Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.03953,0.3744595944881439,-0.95918,-0.2278068356212031,-0.499355,-0.13366841781060154,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,67.9,,False,67.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.4,-,-0.2363,1.2981,-22.1143,-3.9104237502095,4.096854579108191e-07,Benign,0.1931,benign,-3.271,available,https://doi.org/10.1101/2022.10.22.513328 +G105A,NP_000537:p.Gly105Ala,"hg19,17:g.7579372_7579373delinsTG, hg19,17:g.7579373C>G, hg19,17:g.7676055C>G, hg38,17:g.7676054_7676055delinsTG, hg38,17:g.7676055C>G",,,0.905,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2035647, 822977","Uncertain significance, Uncertain significance","1, 1",,,,,P53 DNA-binding domain (PF00870),,4.74204,2.1651978492736816,0.96837,3.595844634971437,2.855205,4.168942317485719,Uncertain,Destabilizing,Destabilizing,Uncertain,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.3766,0.0719,-22.1395,-6.74333955675446,0.8385150035108706,Pathogenic,0.91,pathogenic,-4.057,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105C,NP_000537:p.Gly105Cys,"hg19,17:g.7579374C>A, hg19,17:g.7676056C>A, hg38,17:g.7676056C>A",,,0.942,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,8.40147,1.6158833503723145,4.21054,4.967729080492232,6.306005,6.684599540246116,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4363,0.0719,-22.1395,-6.74333955675446,0.5968165061362787,Uncertain,0.9886,pathogenic,-4.165,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105D,NP_000537:p.Gly105Asp,"hg19,17:g.7579373C>T, hg19,17:g.7676055C>T, hg38,17:g.7676055C>T",,0.0,0.884,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141114,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),,10.68524,2.6855392456054688,-0.28061,6.23231158314923,5.2023150000000005,8.458775791574615,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4368,0.0719,-22.1395,-7.12293207473506,0.5717155087405259,Uncertain,0.9794,pathogenic,-3.926,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105E,NP_000537:p.Gly105Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,9.31168,2.7895538806915283,6.07857,7.128691663377344,7.695125000000001,8.220185831688672,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4361,0.0719,-22.1395,-7.12293207473506,0.870829128776961,Pathogenic,0.9905,pathogenic,-4.108,available,https://doi.org/10.1101/2022.10.22.513328 +G105F,NP_000537:p.Gly105Phe,"hg19,17:g.7579373_7579374delinsAA",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,11.3065,1.8081085681915283,5.2966,5.940668762496702,8.301549999999999,8.623584381248351,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4744,0.0719,-22.1395,-7.12293207473506,0.8686935710805768,Pathogenic,0.9956,pathogenic,-4.443,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105H,NP_000537:p.Gly105His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,16.60802,2.4384047985076904,4.48231,6.138507814054408,10.545165,11.373263907027203,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4491,0.0719,-22.1395,-7.12293207473506,0.7725890143480263,Pathogenic,0.9965,pathogenic,-4.064,available,https://doi.org/10.1101/2022.10.22.513328 +G105I,NP_000537:p.Gly105Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,12.61624,2.447979211807251,5.59456,7.814056382571059,9.1054,10.215148191285529,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.5201,0.0719,-22.1395,-7.12293207473506,0.8675470810174329,Pathogenic,0.995,pathogenic,-4.558,available,https://doi.org/10.1101/2022.10.22.513328 +G105K,NP_000537:p.Gly105Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,9.26855,2.704322338104248,2.62245,7.29699261832041,5.9455,8.282771309160205,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4691,0.0719,-22.1395,-7.12293207473506,0.8626008099471941,Pathogenic,0.9964,pathogenic,-4.225,available,https://doi.org/10.1101/2022.10.22.513328 +G105L,NP_000537:p.Gly105Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,10.81746,2.1339271068573,5.07483,7.072303732727166,7.9461450000000005,8.944881866363584,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4883,0.0719,-22.1395,-7.12293207473506,0.8704061861275223,Pathogenic,0.9936,pathogenic,-4.322,available,https://doi.org/10.1101/2022.10.22.513328 +G105M,NP_000537:p.Gly105Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,7.96868,2.04285740852356,4.58129,6.416522392413629,6.274985,7.192601196206814,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4265,0.0719,-22.1395,-7.12293207473506,0.8279835756097328,Pathogenic,0.9967,pathogenic,-4.442,available,https://doi.org/10.1101/2022.10.22.513328 +G105N,NP_000537:p.Gly105Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,10.65822,2.5629329681396484,1.26735,5.606765559664446,5.962785,8.132492779832223,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4371,0.0719,-22.1395,-7.12293207473506,0.2037088493655584,Benign,0.9872,pathogenic,-3.879,available,https://doi.org/10.1101/2022.10.22.513328 +G105P,NP_000537:p.Gly105Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,14.81872,2.7910168170928955,6.06224,8.646449828277632,10.44048,11.732584914138815,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.5342,0.0719,-22.1395,-7.12293207473506,0.8175572230640045,Pathogenic,0.994,pathogenic,-4.11,available,https://doi.org/10.1101/2022.10.22.513328 +G105Q,NP_000537:p.Gly105Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,9.58294,2.515731811523437,1.88741,6.62437003457448,5.735175,8.10365501728724,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.44,0.0719,-22.1395,-7.12293207473506,0.7489744876253293,Pathogenic,0.9956,pathogenic,-4.222,available,https://doi.org/10.1101/2022.10.22.513328 +G105R,NP_000537:p.Gly105Arg,"hg19,17:g.7579374C>G, hg19,17:g.7676056C>G, hg38,17:g.7676056C>G",,,0.918,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406574,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),,9.06758,2.686685085296631,5.29728,6.837770497741551,7.18243,7.952675248870776,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4531,0.0719,-22.1395,-7.12293207473506,0.8015435684123399,Pathogenic,0.9962,pathogenic,-4.185,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105S,NP_000537:p.Gly105Ser,"hg19,17:g.7579374C>T, hg19,17:g.7676056C>T, hg38,17:g.7676056C>T",,,0.883,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428884,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),,6.67244,2.455232858657837,0.95374,4.290186351214345,3.81309,5.4813131756071725,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.3044,0.0719,-6.8517,-4.36994679958428,0.2968200683582394,Benign,0.9562,pathogenic,-3.686,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105T,NP_000537:p.Gly105Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,11.14628,2.6180052757263184,4.36361,5.971453332992942,7.754945000000001,8.55886666649647,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4594,0.0719,-22.1395,-6.74333955675446,0.756637955227241,Pathogenic,0.9819,pathogenic,-4.068,available,https://doi.org/10.1101/2022.10.22.513328 +G105V,NP_000537:p.Gly105Val,"hg19,17:g.7579372_7579373delinsAA, hg19,17:g.7579373C>A, hg19,17:g.7676055C>A, hg38,17:g.7676055C>A",,,0.919,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634708,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),,11.08696,2.3231773376464844,5.64558,7.022105556719717,8.36627,9.054532778359858,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4633,0.0719,-22.1395,-7.12293207473506,0.8433656754383163,Pathogenic,0.9868,pathogenic,-4.33,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G105W,NP_000537:p.Gly105Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,12.65546,2.112445116043091,5.98571,6.400711227864471,9.320585,9.528085613932236,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4742,0.0719,-22.1395,-7.12293207473506,0.866689999244427,Pathogenic,0.9936,pathogenic,-4.485,available,https://doi.org/10.1101/2022.10.22.513328 +G105Y,NP_000537:p.Gly105Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,11.36728,2.133831739425659,5.21565,6.307356842079503,8.291464999999999,8.83731842103975,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.026,,,,,,,,,7.7,,True,7.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.19,T,-0.4748,0.0719,-22.1395,-7.12293207473506,0.8058493594920272,Pathogenic,0.9927,pathogenic,-4.387,available,https://doi.org/10.1101/2022.10.22.513328 +S106A,NP_000537:p.Ser106Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.38122,-0.0499711036682128,0.23163,-0.1461290803135267,0.306425,0.11754545984323665,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,96.67,T,0.0065,2.1928,-5.5329,-0.319371549765048,1.364787077859729e-07,Benign,0.0748,benign,-2.872,available,https://doi.org/10.1101/2022.10.22.513328 +S106C,NP_000537:p.Ser106Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.06174,0.044329285621643,0.59558,0.4689519425723715,0.32866,0.26534597128618576,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.0528,2.1928,-7.2699,-0.267167543724268,2.088058014168096e-05,Benign,0.074,benign,-3.245,available,https://doi.org/10.1101/2022.10.22.513328 +S106D,NP_000537:p.Ser106Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.44914,0.575306236743927,-0.09422,-0.0870112401769396,0.17746,0.18106437991153018,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.0863,2.1928,-4.3954,-0.0350143755602524,2.2175866141669507e-11,Benign,0.0825,benign,-2.882,available,https://doi.org/10.1101/2022.10.22.513328 +S106E,NP_000537:p.Ser106Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.04821,0.2237058877944946,-0.05306,-0.0649431831641528,-0.002425,-0.0083665915820764,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.0521,2.1928,-2.948,-0.193014108031156,6.206714105322146e-12,Benign,0.1379,benign,-2.916,available,https://doi.org/10.1101/2022.10.22.513328 +S106F,NP_000537:p.Ser106Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.41548,0.7393442988395691,0.20782,-0.1864641915988862,0.31165,0.11450790420055691,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.1563,2.1928,-22.1426,-2.79212075860017,0.0004047174237045,Benign,0.2,benign,-3.338,available,https://doi.org/10.1101/2022.10.22.513328 +S106G,NP_000537:p.Ser106Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.93486,0.6237335205078125,0.80714,0.5229238672394323,0.871,0.7288919336197162,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,DOWN,stabilizing,neutral,False,neutral,neutral,96.67,T,-0.0094,2.1928,-6.8548,-2.07778115524425,0.0001150350450643,Benign,0.0688,benign,-3.065,available,https://doi.org/10.1101/2022.10.22.513328 +S106H,NP_000537:p.Ser106His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.79126,0.4289040565490722,-0.38299,-0.4319499154805595,0.20413499999999998,0.17965504225972023,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.1575,2.1928,-22.1426,-1.9537294209898,3.855441706675246e-07,Benign,0.1117,benign,-3.127,available,https://doi.org/10.1101/2022.10.22.513328 +S106I,NP_000537:p.Ser106Ile,"hg19,17:g.7579370C>A, hg38,17:g.7676052C>A",,,0.450,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",629791,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),,0.18132,0.3090525865554809,-0.18571,-0.2746511021352549,-0.0021949999999999886,-0.046665551067627445,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.1594,2.1928,-22.1426,-2.28545542961298,0.000257745181244,Benign,0.0984,benign,-3.34,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S106K,NP_000537:p.Ser106Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.38199,-0.0741441249847412,-0.09218,-0.11657064981756,-0.237085,-0.24928032490878,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.0909,2.1928,-7.2699,-0.641565901758129,4.453103796561074e-07,Benign,0.1643,benign,-3.18,available,https://doi.org/10.1101/2022.10.22.513328 +S106L,NP_000537:p.Ser106Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.02523,0.4393185973167419,-0.01293,-0.6585314936207065,-0.01908,-0.34188074681035324,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.0798,2.1928,-7.2699,-1.41211486901111,2.3304879131265587e-07,Benign,0.1206,benign,-3.104,available,https://doi.org/10.1101/2022.10.22.513328 +S106M,NP_000537:p.Ser106Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.47063,0.3641697764396667,0.61565,-0.3677395837186514,0.07251000000000002,-0.41918479185932567,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.1267,2.1928,-22.1426,-2.73274032969055,0.0127804922394187,Benign,0.1661,benign,-3.484,available,https://doi.org/10.1101/2022.10.22.513328 +S106N,NP_000537:p.Ser106Asn,"hg19,17:g.7579370C>T",,,0.340,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,0.45753,0.4275082945823669,-0.41293,-0.2643340135269301,0.022299999999999986,0.09659799323653495,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.01,2.1928,-4.3954,-0.0674115432093849,3.2469969733363184e-11,Benign,0.0567,benign,-2.846,available,https://doi.org/10.1101/2022.10.22.513328 +S106P,NP_000537:p.Ser106Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-1.03859,-0.464618444442749,0.37381,0.8235197963823226,-0.33238999999999996,-0.10753510180883863,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.1227,2.1928,-0.7834,-1.09494593675366,9.454257361097516e-09,Benign,0.1161,benign,-2.94,available,https://doi.org/10.1101/2022.10.22.513328 +S106Q,NP_000537:p.Ser106Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.3528,0.0291544795036315,-0.11224,-0.0569287010814067,0.12028,0.14793564945929666,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.0443,2.1928,-7.2699,-1.23191517597685,1.3578309439003664e-07,Benign,0.1524,benign,-3.021,available,https://doi.org/10.1101/2022.10.22.513328 +S106R,NP_000537:p.Ser106Arg,"hg19,17:g.7579369G>C, hg19,17:g.7676051G>C, hg38,17:g.7676051G>C",,,0.635,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",492752,Pathogenic,3,,,,,P53 DNA-binding domain (PF00870),,-0.03205,0.0998480319976806,-0.23707,-0.3175074708491437,-0.13456,-0.17477873542457187,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.1721,2.1928,-22.1426,-2.35626639900643,0.0002762297048018,Benign,0.1535,benign,-3.241,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S106T,NP_000537:p.Ser106Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.23152,0.3643913269042969,-0.07347,-0.0684615070317806,0.07902500000000001,0.0815292464841097,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,neutral,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,0.0217,2.1928,-4.3954,-0.315813291316464,1.1327288542254062e-09,Benign,0.066,benign,-2.841,available,https://doi.org/10.1101/2022.10.22.513328 +S106V,NP_000537:p.Ser106Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.52453,0.3350586295127868,-0.17449,-0.2371628112705326,0.17502,0.1436835943647337,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.054,2.1928,-6.5329,-0.507336369016706,1.513084760105849e-07,Benign,0.1084,benign,-3.117,available,https://doi.org/10.1101/2022.10.22.513328 +S106W,NP_000537:p.Ser106Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.13299,0.680148184299469,0.16463,-0.4480352569618229,0.01582,-0.2905126284809114,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.166,2.1928,-22.1426,-3.04852341281063,0.0372724252396779,Benign,0.2967,benign,-3.706,available,https://doi.org/10.1101/2022.10.22.513328 +S106Y,NP_000537:p.Ser106Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.41314,0.6663082242012024,0.17041,-0.0904541556756255,0.291775,0.16134292216218726,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,95.9,P,True,95.9,0.503,uncertain,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,96.67,T,-0.1611,2.1928,-22.1426,-2.77670836141573,0.0004847956463587,Benign,0.1548,benign,-3.306,available,https://doi.org/10.1101/2022.10.22.513328 +Y107A,NP_000537:p.Tyr107Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,3.03168,2.521021842956543,3.07177,4.2840327642064,3.0517250000000002,3.6578563821032004,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.3389,1.2242,-22.1426,-4.87067551376095,0.5944614508237123,Uncertain,0.6824,pathogenic,-3.66,available,https://doi.org/10.1101/2022.10.22.513328 +Y107C,NP_000537:p.Tyr107Cys,"hg19,17:g.7579367T>C, hg38,17:g.7676049T>C",,,0.883,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142691,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),,3.04658,1.6729727983474731,2.62993,4.317990604022473,2.838255,3.6822853020112367,Uncertain,Destabilizing,Uncertain,Uncertain,Destabilizing,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.2299,1.2242,-6.5329,-3.04953526536538,0.0007360667947813,Benign,0.1054,benign,-3.272,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y107D,NP_000537:p.Tyr107Asp,"hg19,17:g.7579368A>C, hg19,17:g.7676050A>C, hg38,17:g.7676050A>C",,,0.893,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",641482,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),,3.15109,2.3976364135742188,2.85476,5.302888076296572,3.0029250000000003,4.226989038148286,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.2853,1.2242,-8.8547,-5.59159700627411,0.3691797235792885,Uncertain,0.8344,pathogenic,-3.82,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y107E,NP_000537:p.Tyr107Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,3.37708,2.916128396987915,2.32381,5.209855825164673,2.8504449999999997,4.2934679125823365,Uncertain,Destabilizing,Destabilizing,Uncertain,Destabilizing,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.3818,1.2242,-22.1426,-5.59159700627411,0.8088041795014813,Pathogenic,0.8884,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328 +Y107F,NP_000537:p.Tyr107Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.59694,0.2317721843719482,-0.0119,1.230731656034391,-0.30442,0.3168958280171955,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.18,T,-0.0933,1.2242,-5.8549,-0.707884473428679,0.0002022960030985,Benign,0.0791,benign,-3.08,available,https://doi.org/10.1101/2022.10.22.513328 +Y107G,NP_000537:p.Tyr107Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,3.95286,2.0730552673339844,4.60476,5.94394361916474,4.27881,4.94840180958237,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.4095,1.2242,-22.1426,-6.12475295393761,0.7573131343035386,Pathogenic,0.6677,pathogenic,-3.93,available,https://doi.org/10.1101/2022.10.22.513328 +Y107H,NP_000537:p.Tyr107His,"hg19,17:g.7579368A>G, hg38,17:g.7676050A>G",0.00041422380831,8.35488362841e-05,0.569,"COSMIC,ClinVar,saturation_mutlist",140786,Benign,3,,,,,P53 DNA-binding domain (PF00870),,2.79494,1.3153132200241089,1.20714,3.057340393742068,2.00104,2.926140196871034,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.1365,1.2242,-0.5695,-1.59656500473781,2.380978682489339e-07,Benign,0.1966,benign,-2.881,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y107I,NP_000537:p.Tyr107Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,1.77499,2.521415948867798,0.92993,3.584616859890112,1.35246,2.679803429945056,Neutral,Uncertain,Destabilizing,Neutral,Uncertain,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.351,1.2242,-22.1426,-4.56681478617394,0.260375439748877,Benign,0.6974,pathogenic,-3.732,available,https://doi.org/10.1101/2022.10.22.513328 +Y107K,NP_000537:p.Tyr107Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,1.90406,2.6183223724365234,2.22653,5.744599109531957,2.065295,3.8243295547659786,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.4071,1.2242,-22.1426,-6.12475295393761,0.7825363331351646,Pathogenic,0.8746,pathogenic,-3.824,available,https://doi.org/10.1101/2022.10.22.513328 +Y107L,NP_000537:p.Tyr107Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.56148,2.3221595287323,0.10442,3.036604462330871,0.33294999999999997,1.7990422311654355,Neutral,Uncertain,Destabilizing,Neutral,Neutral,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.2433,1.2242,-5.5329,-2.72760035987511,4.154539960913622e-06,Benign,0.456,ambiguous,-3.141,available,https://doi.org/10.1101/2022.10.22.513328 +Y107M,NP_000537:p.Tyr107Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.67031,1.9607864618301392,1.81531,3.223253797899146,1.24281,1.946781898949573,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.2802,1.2242,-22.1426,-4.25892139404297,0.0582015325428709,Benign,0.7267,pathogenic,-3.657,available,https://doi.org/10.1101/2022.10.22.513328 +Y107N,NP_000537:p.Tyr107Asn,"hg19,17:g.7579368A>T, hg38,17:g.7676050A>T",,,0.853,"ClinVar,saturation_mutlist",406572,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),,2.34748,2.062537670135498,2.01088,4.217988337727657,2.1791799999999997,3.2827341688638283,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.3321,1.2242,-22.1426,-5.28636910841999,0.3290125044520225,Uncertain,0.4591,ambiguous,-3.62,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y107P,NP_000537:p.Tyr107Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,3.01977,2.345711708068848,16.70918,6.697352865807533,9.864475,4.858561432903766,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.4631,1.2242,-22.1426,-6.12475295393761,0.5457743752717799,Uncertain,0.9417,pathogenic,-3.756,available,https://doi.org/10.1101/2022.10.22.513328 +Y107Q,NP_000537:p.Tyr107Gln,"hg38,17:g.7676048_7676050delinsTTG",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,2.56914,2.5457687377929688,1.5051,4.385613931665427,2.03712,3.4773769658327134,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.3566,1.2242,-22.1426,-5.59159700627411,0.2982900482494743,Benign,0.7612,pathogenic,-3.446,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y107R,NP_000537:p.Tyr107Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,2.28579,2.23134994506836,2.5483,4.768106387743816,2.417045,3.526948193871908,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.4024,1.2242,-22.1426,-6.12475295393761,0.4526033376308064,Uncertain,0.6924,pathogenic,-3.786,available,https://doi.org/10.1101/2022.10.22.513328 +Y107S,NP_000537:p.Tyr107Ser,"hg19,17:g.7579367T>G, hg38,17:g.7676049T>G",,,0.854,"cBioPortal,ClinVar,saturation_mutlist",142414,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),,3.8629,2.58105993270874,3.56327,5.086781982706576,3.713085,4.474840991353288,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.3436,1.2242,-22.1426,-4.2778193350046,0.3850196591047544,Uncertain,0.448,ambiguous,-3.554,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y107T,NP_000537:p.Tyr107Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,3.65266,2.5499091148376465,2.1,4.242321835533507,2.8763300000000003,3.9474909177667534,Uncertain,Destabilizing,Destabilizing,Uncertain,Destabilizing,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.3623,1.2242,-22.1426,-5.09348857870052,0.6883754420365267,Pathogenic,0.7256,pathogenic,-3.859,available,https://doi.org/10.1101/2022.10.22.513328 +Y107V,NP_000537:p.Tyr107Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,1.38265,2.6183090209960938,0.63265,3.445207208948766,1.00765,2.413928604474383,Neutral,Uncertain,Destabilizing,Neutral,Uncertain,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.18,T,-0.2727,1.2242,-8.8547,-4.6678212731293,0.0403891196651421,Benign,0.5588,ambiguous,-3.514,available,https://doi.org/10.1101/2022.10.22.513328 +Y107W,NP_000537:p.Tyr107Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.5386,0.9648213386535645,0.50068,2.162637673535595,0.51964,1.3506188367677976,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.027,,,,,,,,,23.9,,True,23.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.18,T,-0.2565,1.2242,-22.1426,-2.91834202370705,0.0519728985717454,Benign,0.2791,benign,-3.593,available,https://doi.org/10.1101/2022.10.22.513328 +G108A,NP_000537:p.Gly108Ala,"hg19,17:g.7579364C>G",,,0.668,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,3.68635,1.5219014883041382,1.47415,2.26753594151458,2.58025,2.97694297075729,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.0759,2.4188,-5.536,-1.49794798507654,0.0214682676869079,Benign,0.1908,benign,-3.338,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G108C,NP_000537:p.Gly108Cys,"hg19,17:g.7579365C>A, hg38,17:g.7676047C>A",,7.9577918719e-06,0.654,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1487358,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),,4.15917,0.7713181972503662,2.00034,2.595504939483133,3.0797549999999996,3.3773374697415663,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.1526,2.4188,-8.8578,-1.84053211638479,0.1086093222249094,Benign,0.2214,benign,-3.612,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G108D,NP_000537:p.Gly108Asp,"hg19,17:g.7579364C>T, hg38,17:g.7676046C>T",,,0.651,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1371608,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),,4.59982,1.7008659839630127,3.06497,1.877476785594748,3.832395,3.238648392797374,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.13,2.4188,-4.3344,-0.592226911613634,6.073865762796207e-07,Benign,0.2549,benign,-3.03,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G108E,NP_000537:p.Gly108Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,4.79557,1.8010544776916504,3.04898,2.190621203859295,3.922275,3.4930956019296473,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.1524,2.4188,-8.8578,-1.76181311704691,0.0001444444056638,Benign,0.423,ambiguous,-3.258,available,https://doi.org/10.1101/2022.10.22.513328 +G108F,NP_000537:p.Gly108Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,3.84085,1.449271321296692,1.57789,1.8488474614661785,2.70937,2.8448487307330894,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.2585,2.4188,-22.1457,-3.25954254496378,0.194298664803543,Benign,0.7637,pathogenic,-3.802,available,https://doi.org/10.1101/2022.10.22.513328 +G108H,NP_000537:p.Gly108His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,5.16646,1.30828857421875,0.92925,1.6602610448417232,3.0478549999999998,3.4133605224208616,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.1347,2.4188,-2.8356,-1.56882317937165,0.0142487504878981,Benign,0.3437,ambiguous,-3.381,available,https://doi.org/10.1101/2022.10.22.513328 +G108I,NP_000537:p.Gly108Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,6.31473,2.082249164581299,5.58571,3.5588187272632887,5.95022,4.936774363631645,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.3042,2.4188,-22.1457,-4.2455659841863,0.4946248092626925,Uncertain,0.7466,pathogenic,-3.949,available,https://doi.org/10.1101/2022.10.22.513328 +G108K,NP_000537:p.Gly108Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,3.49384,1.5488706827163696,1.46633,1.8128702498197529,2.480085,2.6533551249098766,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.2531,2.4188,-22.1457,-4.17457807775078,0.1546742590764195,Benign,0.5099,ambiguous,-3.607,available,https://doi.org/10.1101/2022.10.22.513328 +G108L,NP_000537:p.Gly108Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,4.03563,1.5307626724243164,2.13878,2.065527609392096,3.087205,3.0505788046960483,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.2046,2.4188,-8.8578,-2.94413681936001,0.0896168272666343,Benign,0.658,pathogenic,-3.64,available,https://doi.org/10.1101/2022.10.22.513328 +G108M,NP_000537:p.Gly108Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,4.14897,1.503894567489624,1.9898,2.0620392556965093,3.069385,3.105504627848255,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.2106,2.4188,-22.1457,-4.2455659841863,0.5553894159457928,Uncertain,0.7367,pathogenic,-3.96,available,https://doi.org/10.1101/2022.10.22.513328 +G108N,NP_000537:p.Gly108Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,3.62068,1.2167589664459229,1.35034,1.5840288983510615,2.48551,2.6023544491755306,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.1351,2.4188,-5.273,-0.567752297695312,7.947562315688327e-05,Benign,0.206,benign,-3.041,available,https://doi.org/10.1101/2022.10.22.513328 +G108P,NP_000537:p.Gly108Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,8.8374,2.5605835914611816,5.37687,7.9427354707881666,7.107135,8.390067735394084,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.3183,2.4188,-22.1457,-4.96854621939755,0.4838326940140388,Uncertain,0.9416,pathogenic,-3.782,available,https://doi.org/10.1101/2022.10.22.513328 +G108Q,NP_000537:p.Gly108Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,4.36596,1.6102161407470703,2.09014,2.1702604836195207,3.22805,3.2681102418097607,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.1563,2.4188,-8.8578,-2.14100404577522,0.0029453336238873,Benign,0.3805,ambiguous,-3.355,available,https://doi.org/10.1101/2022.10.22.513328 +G108R,NP_000537:p.Gly108Arg,"hg19,17:g.7579365C>G, hg38,17:g.7676047C>G",,,0.724,"COSMIC,ClinVar,saturation_mutlist",458535,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),,3.83527,1.6225119829177856,1.61395,1.6122793443012655,2.72461,2.7237746721506326,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.1613,2.4188,-7.273,-2.2979062061763,0.006206502787866,Benign,0.3172,benign,-3.402,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G108S,NP_000537:p.Gly108Ser,"hg19,17:g.7579365C>T, hg19,17:g.7676047C>T, hg38,17:g.7676047C>T",,1.19366878079e-05,0.612,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142431,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),,4.31114,1.611213207244873,1.52789,2.1039083707928854,2.919515,3.2075241853964425,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.0618,2.4188,-1.6196,-1.31631783038784,0.0005365714941366,Benign,0.1259,benign,-3.156,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G108T,NP_000537:p.Gly108Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,6.52155,2.0069174766540527,3.61122,2.9735123421499923,5.066385,4.747531171074996,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.1455,2.4188,-2.9511,-1.68965030779181,0.600777146333076,Uncertain,0.3901,ambiguous,-3.656,available,https://doi.org/10.1101/2022.10.22.513328 +G108V,NP_000537:p.Gly108Val,"hg19,17:g.7579364C>A, hg19,17:g.7676046C>A, hg38,17:g.7676046C>A",,,0.658,"cBioPortal,ClinVar,saturation_mutlist",1729287,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),,6.60819,2.0516626834869385,5.41905,3.322662716398959,6.0136199999999995,4.96542635819948,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.2474,2.4188,-22.1457,-3.87038867333747,0.5655542104368011,Uncertain,0.6061,pathogenic,-3.749,available,https://doi.org/10.1101/2022.10.22.513328 +G108W,NP_000537:p.Gly108Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,4.95439,1.7198901176452637,1.72143,1.6600380460783797,3.33791,3.3072140230391898,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.2583,2.4188,-22.1457,-3.25954254496378,0.5745409340710443,Uncertain,0.6991,pathogenic,-4.093,available,https://doi.org/10.1101/2022.10.22.513328 +G108Y,NP_000537:p.Gly108Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,4.04219,1.6320908069610596,1.43469,2.028346589911937,2.7384399999999998,3.0352682949559684,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,False,0.045,,,,,,,,,22.0,,True,22.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.81,T,-0.2589,2.4188,-22.1457,-3.25954254496378,0.5037951790693465,Uncertain,0.5776,pathogenic,-3.78,available,https://doi.org/10.1101/2022.10.22.513328 +F109A,NP_000537:p.Phe109Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.93713,2.587923049926758,4.09014,4.521688885749124,4.513635,4.729409442874562,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.436,0.1397,-22.1457,-7.31938189731103,0.848125609305831,Pathogenic,0.9976,pathogenic,-4.468,available,https://doi.org/10.1101/2022.10.22.513328 +F109C,NP_000537:p.Phe109Cys,"hg19,17:g.7579361A>C, hg19,17:g.7676043A>C, hg38,17:g.7676043A>C",,,0.965,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634784,Likely pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.99925,1.7968709468841553,4.64898,4.695533090979856,4.824115,4.847391545489928,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.4041,0.1397,-22.1457,-7.31938189731103,0.8652860751663696,Pathogenic,0.9844,pathogenic,-4.392,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F109D,NP_000537:p.Phe109Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.22407,2.5670711994171143,5.35816,5.595704695120936,5.791115,5.909887347560469,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.5589,0.1397,-22.1457,-7.31938189731103,0.8650156903297376,Pathogenic,0.9995,pathogenic,-4.754,available,https://doi.org/10.1101/2022.10.22.513328 +F109E,NP_000537:p.Phe109Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.24092,2.879397392272949,5.18741,5.132588099898088,5.7141649999999995,5.6867540499490445,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.5283,0.1397,-22.1457,-7.31938189731103,0.8708635610686242,Pathogenic,0.9994,pathogenic,-4.678,available,https://doi.org/10.1101/2022.10.22.513328 +F109G,NP_000537:p.Phe109Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.42532,2.920318841934204,6.25612,6.496629868487924,6.34072,6.460974934243962,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.4713,0.1397,-22.1457,-7.31938189731103,0.8708540421658563,Pathogenic,0.9973,pathogenic,-4.63,available,https://doi.org/10.1101/2022.10.22.513328 +F109H,NP_000537:p.Phe109His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.26418,3.027261018753052,2.92211,2.6360369055859545,3.593145,3.450108452792977,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.4635,0.1397,-22.1457,-4.40622457131549,0.8695787551898566,Pathogenic,0.9969,pathogenic,-4.486,available,https://doi.org/10.1101/2022.10.22.513328 +F109I,NP_000537:p.Phe109Ile,"hg19,17:g.7579362A>T, hg38,17:g.7676044A>T",,,0.837,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2627017,Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.81102,1.5692709684371948,3.70986,2.962613779949597,3.26044,2.8868168899747984,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.3799,0.1397,-22.1457,-6.12358780216624,0.8692404219148717,Pathogenic,0.9571,pathogenic,-4.289,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F109K,NP_000537:p.Phe109Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.49842,2.912477731704712,5.75442,5.3694521671754165,5.6264199999999995,5.433936083587708,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.5352,0.1397,-22.1457,-7.31938189731103,0.8707599885307575,Pathogenic,0.9991,pathogenic,-4.709,available,https://doi.org/10.1101/2022.10.22.513328 +F109L,NP_000537:p.Phe109Leu,"hg19,17:g.7579360G>T, hg38,17:g.7676042G>T",,,0.715,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.34522,1.539331555366516,2.47449,2.2652480411343854,2.409855,2.305234020567193,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.261,0.1397,-6.273,-3.87109101487644,0.000299253831507,Benign,0.9839,pathogenic,-3.413,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F109M,NP_000537:p.Phe109Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.47409,1.4806554317474363,2.58231,2.557717559415813,2.0282,2.0159037797079065,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.373,0.1397,-22.1457,-6.12358780216624,0.8610876314967335,Pathogenic,0.9667,pathogenic,-4.347,available,https://doi.org/10.1101/2022.10.22.513328 +F109N,NP_000537:p.Phe109Asn,"hg19,17:g.7579361_7579363inv, hg38,17:g.7676043_7676045inv",,,,"ClinVar,saturation_mutlist",2417541,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.58986,2.793520212173462,4.49558,4.269955350717046,5.04272,4.929907675358523,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.4886,0.1397,-22.1457,-7.31938189731103,0.8645942659804584,Pathogenic,0.9983,pathogenic,-4.67,available,https://doi.org/10.1101/2022.10.22.513328 +F109P,NP_000537:p.Phe109Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.49121,2.1482107639312744,10.08741,8.409827458257324,8.78931,7.950518729128662,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.5593,0.1397,-22.1457,-7.31938189731103,0.8708609535611396,Pathogenic,0.9998,pathogenic,-4.494,available,https://doi.org/10.1101/2022.10.22.513328 +F109Q,NP_000537:p.Phe109Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.18026,2.9547505378723145,3.73027,4.145810335815253,4.455265,4.663035167907626,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.4906,0.1397,-22.1457,-7.31938189731103,0.8655107856719801,Pathogenic,0.9988,pathogenic,-4.582,available,https://doi.org/10.1101/2022.10.22.513328 +F109R,NP_000537:p.Phe109Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.15362,2.7318332195281982,5.66973,4.327026053831108,5.911675000000001,5.240323026915554,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.5366,0.1397,-22.1457,-7.31938189731103,0.8704784288805557,Pathogenic,0.9975,pathogenic,-4.652,available,https://doi.org/10.1101/2022.10.22.513328 +F109S,NP_000537:p.Phe109Ser,"hg19,17:g.7579361A>G, hg19,17:g.7676043A>G, hg38,17:g.7676043A>G",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",423970,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.06743,2.509641647338867,5.02177,5.367085416117732,5.5446,5.717257708058866,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.4149,0.1397,-22.1457,-7.31938189731103,0.8704216588436751,Pathogenic,0.9989,pathogenic,-4.476,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F109T,NP_000537:p.Phe109Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.52363,2.48552680015564,4.1034,4.550986087941436,4.813515,5.037308043970718,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.4612,0.1397,-22.1457,-7.31938189731103,0.8625526186042833,Pathogenic,0.9984,pathogenic,-4.526,available,https://doi.org/10.1101/2022.10.22.513328 +F109V,NP_000537:p.Phe109Val,"hg19,17:g.7579362A>C, hg19,17:g.7676044A>C, hg38,17:g.7676044A>C",,,0.875,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",389644,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.45501,1.677072525024414,2.88333,3.308195262133121,3.1691700000000003,3.381602631066561,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.03,-,-0.3013,0.1397,-7.8579,-6.12358780216624,0.8608460390800319,Pathogenic,0.9749,pathogenic,-4.192,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F109W,NP_000537:p.Phe109Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.4606,1.806148052215576,0.43673,0.2688458972527957,-0.011935000000000001,-0.09587705137360217,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.03,-,-0.3595,0.1397,-22.1457,-4.40622457131549,0.8708214964107495,Pathogenic,0.9532,pathogenic,-4.493,available,https://doi.org/10.1101/2022.10.22.513328 +F109Y,NP_000537:p.Phe109Tyr,"hg19,17:g.7579361A>T, hg38,17:g.7676043A>T",,,0.848,"cBioPortal,ClinVar,saturation_mutlist",1054035,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.78447,2.023469924926758,0.54558,0.2489822138164393,0.665025,0.5167261069082196,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.093,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.03,-,-0.3278,0.1397,-22.1457,-4.40622457131549,0.8641792744217547,Pathogenic,0.8463,pathogenic,-4.13,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110A,NP_000537:p.Arg110Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.21768,0.5993502140045166,0.79218,0.5635315789456619,1.00493,0.890605789472831,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.1271,2.3313,-8.8578,-1.9647838107166,0.0004081953569178,Benign,0.3074,benign,-3.389,available,https://doi.org/10.1101/2022.10.22.513328 +R110C,NP_000537:p.Arg110Cys,"hg19,17:g.7579359G>A, hg19,17:g.7579359_7579360delinsAA, hg19,17:g.7676041G>A, hg38,17:g.7676041G>A, hg38,17:g.7676041_7676042delinsAA",,1.98974881411e-05,0.471,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142206,Uncertain significance,3,Uncertain significance,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.9324,0.7518410682678223,1.20272,0.9491695231292848,1.06756,0.9407847615646424,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.1241,2.3313,-6.536,-1.39081632871217,2.756682742910876e-06,Benign,0.0983,benign,-3.214,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110D,NP_000537:p.Arg110Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.90766,2.190981149673462,0.65476,0.9301023705762568,1.28121,1.4188811852881282,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.1785,2.3313,-1.0898,-1.15873468370403,6.302676267013781e-05,Benign,0.389,ambiguous,-3.109,available,https://doi.org/10.1101/2022.10.22.513328 +R110E,NP_000537:p.Arg110Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.88359,1.842614769935608,1.21259,0.6077632869297475,1.04809,0.7456766434648737,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.1317,2.3313,-2.6485,-0.0195238306738232,6.058390849595864e-07,Benign,0.2304,benign,-2.984,available,https://doi.org/10.1101/2022.10.22.513328 +R110F,NP_000537:p.Arg110Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.03994,1.1880890130996704,-0.57721,-0.0938424005990556,-0.268635,-0.0269512002995278,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.227,2.3313,-22.1457,-2.79267633772652,0.0096157920499123,Benign,0.3533,ambiguous,-3.673,available,https://doi.org/10.1101/2022.10.22.513328 +R110G,NP_000537:p.Arg110Gly,"hg19,17:g.7579359G>C, hg38,17:g.7676041G>C",,,0.577,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",823452,Likely pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.5052,1.184345006942749,1.68435,1.2407318233278437,1.594775,1.372965911663922,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.2303,2.3313,-22.1457,-3.3371356995395,0.0037290696055361,Benign,0.2211,benign,-3.364,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110H,NP_000537:p.Arg110His,"hg19,17:g.7579358C>T, hg38,17:g.7676040C>T",3.18694626809e-05,4.7754731698e-05,0.592,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127808,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.04307,0.9194382429122924,0.21429,0.2355733234713403,1.1286800000000001,1.1393216617356703,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.0748,2.3313,-4.5361,-0.70853961877809,2.8171827076627353e-10,Benign,0.0631,benign,-2.962,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110I,NP_000537:p.Arg110Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.76357,1.1823045015335083,1.34286,-0.0361151298635825,1.053215,0.36372743506820876,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.2243,2.3313,-22.1457,-3.36954043060331,0.140141726442351,Benign,0.2669,benign,-3.834,available,https://doi.org/10.1101/2022.10.22.513328 +R110K,NP_000537:p.Arg110Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.53651,0.4353084564208984,0.93435,0.4031982965140429,0.73543,0.46985414825702143,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.53,E,0.0026,2.3313,-4.9511,-1.20405873836924,2.935192105769949e-07,Benign,0.1216,benign,-2.942,available,https://doi.org/10.1101/2022.10.22.513328 +R110L,NP_000537:p.Arg110Leu,"hg19,17:g.7579358C>A, hg19,17:g.7676040C>A, hg38,17:g.7676040C>A",,0.0,0.632,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406597,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.75567,1.5558946132659912,0.79252,-0.0463583728618244,0.774095,0.35465581356908776,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.1244,2.3313,-7.8579,-2.17467226116893,0.000308078665055,Benign,0.2152,benign,-3.443,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110M,NP_000537:p.Arg110Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.12183,1.0298001766204834,0.78231,0.1876003071171078,0.45206999999999997,0.1547151535585539,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.1632,2.3313,-22.1457,-3.72679073233043,0.0789149760461895,Benign,0.3399,benign,-3.773,available,https://doi.org/10.1101/2022.10.22.513328 +R110N,NP_000537:p.Arg110Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.28485,1.1749788522720337,0.8051,0.6409565985528561,1.044975,0.9629032992764281,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.1318,2.3313,-6.858,-1.06687406706304,1.6016189840234238e-05,Benign,0.3016,benign,-3.088,available,https://doi.org/10.1101/2022.10.22.513328 +R110P,NP_000537:p.Arg110Pro,"hg19,17:g.7579357_7579358delinsGG, hg19,17:g.7579358C>G, hg19,17:g.7676040C>G, hg38,17:g.7676039_7676040delinsGG, hg38,17:g.7676040C>G",,,0.593,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","641505, 233627","Pathogenic, Pathogenic","1, 3",Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,5.14219,3.37915587425232,6.93061,4.461961175232068,6.0364,4.802075587616034,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.337,2.3313,-22.1457,-4.23188871816848,0.0752451657410477,Benign,0.9045,pathogenic,-3.666,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110Q,NP_000537:p.Arg110Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.64606,0.9091231822967528,0.55408,0.549179189235291,0.60007,0.5976195946176455,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.0736,2.3313,-3.3344,0.126450236844939,2.152850264199561e-09,Benign,0.0792,benign,-2.879,available,https://doi.org/10.1101/2022.10.22.513328 +R110S,NP_000537:p.Arg110Ser,"hg19,17:g.7579359G>T, hg38,17:g.7676041G>T",,,0.525,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",140921,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.03816,0.19382905960083,1.01293,0.730073877659429,1.0255450000000002,0.8841169388297145,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.1954,2.3313,-22.1457,-2.41640473303228,2.399367523182605e-05,Benign,0.2343,benign,-3.178,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R110T,NP_000537:p.Arg110Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.76511,0.5527032613754272,0.89898,0.4183378062701298,0.8320449999999999,0.5917239031350648,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.115,2.3313,-5.536,-1.61795210105221,1.1441533290724637e-06,Benign,0.1674,benign,-2.992,available,https://doi.org/10.1101/2022.10.22.513328 +R110V,NP_000537:p.Arg110Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.88326,1.0470666885375977,1.21939,0.1110775654042461,1.051325,0.49716878270212306,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.2114,2.3313,-22.1457,-3.72679073233043,0.0298696001719312,Benign,0.2727,benign,-3.668,available,https://doi.org/10.1101/2022.10.22.513328 +R110W,NP_000537:p.Arg110Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.43392,1.2619497776031494,-0.44864,-0.3574909829346878,0.4926400000000001,0.5382145085326562,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.2126,2.3313,-22.1457,-3.29847407890407,0.0804512369816558,Benign,0.1749,benign,-3.93,available,https://doi.org/10.1101/2022.10.22.513328 +R110Y,NP_000537:p.Arg110Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.18807,1.177680730819702,-0.57177,-0.0622752250058006,-0.19185000000000002,0.0628973874970997,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.075,,,Uncertain,,Uncertain,,,Uncertain,46.0,,False,46.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.53,E,-0.2163,2.3313,-22.1457,-2.83717329368476,0.0297454375782944,Benign,0.2093,benign,-3.657,available,https://doi.org/10.1101/2022.10.22.513328 +L111A,NP_000537:p.Leu111Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.49843,2.3078174591064453,4.34456,3.133998278438242,4.421495,3.816214139219121,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.93,E,-0.3209,1.0662,-22.1488,-6.30801522472044,0.7161328193554986,Pathogenic,0.8123,pathogenic,-4.048,available,https://doi.org/10.1101/2022.10.22.513328 +L111C,NP_000537:p.Leu111Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.49183,1.2491501569747925,3.4619,3.123518195710431,3.476865,3.307674097855216,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.93,E,-0.3102,1.0662,-22.1488,-6.40292243487766,0.6454205371135974,Uncertain,0.8415,pathogenic,-4.215,available,https://doi.org/10.1101/2022.10.22.513328 +L111D,NP_000537:p.Leu111Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.42926,3.23708438873291,4.97857,4.106453592914454,5.203915,4.767856796457227,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.93,E,-0.4425,1.0662,-22.1488,-6.86455845713059,0.8592931658937847,Pathogenic,0.9981,pathogenic,-4.584,available,https://doi.org/10.1101/2022.10.22.513328 +L111E,NP_000537:p.Leu111Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.8097,2.9662044048309326,4.62381,3.586114803900786,4.716755,4.197907401950394,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.93,E,-0.4105,1.0662,-22.1488,-6.86455845713059,0.8700309809272802,Pathogenic,0.9862,pathogenic,-4.526,available,https://doi.org/10.1101/2022.10.22.513328 +L111F,NP_000537:p.Leu111Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.2619,1.6972917318344116,2.38367,1.163522610710085,4.822785,4.212711305355042,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.93,E,-0.2544,1.0662,-22.1488,-4.8343986237693,0.4240487719978994,Uncertain,0.7154,pathogenic,-3.795,available,https://doi.org/10.1101/2022.10.22.513328 +L111G,NP_000537:p.Leu111Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.07119,2.959062099456787,5.91973,4.78338045162013,5.49546,4.927285225810065,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.93,E,-0.3958,1.0662,-22.1488,-6.86455845713059,0.8708634107215206,Pathogenic,0.9746,pathogenic,-4.53,available,https://doi.org/10.1101/2022.10.22.513328 +L111H,NP_000537:p.Leu111His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.86993,3.0875041484832764,3.68435,2.3564932029875534,4.77714,4.113211601493777,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.93,E,-0.3633,1.0662,-22.1488,-6.0104303210959,0.8684440243492931,Pathogenic,0.9742,pathogenic,-4.443,available,https://doi.org/10.1101/2022.10.22.513328 +L111I,NP_000537:p.Leu111Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.70019,0.3994123935699463,0.97381,1.2948553860866825,1.337,1.4975226930433414,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.93,E,-0.1192,1.0662,-7.2761,-2.29501946629457,0.0518473711875908,Benign,0.1694,benign,-3.454,available,https://doi.org/10.1101/2022.10.22.513328 +L111K,NP_000537:p.Leu111Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.0528,2.959569215774536,5.63435,4.150927016051639,4.843575,4.10186350802582,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.93,E,-0.3417,1.0662,-8.8609,-6.86455845713059,0.8701563980423375,Pathogenic,0.9828,pathogenic,-4.594,available,https://doi.org/10.1101/2022.10.22.513328 +L111M,NP_000537:p.Leu111Met,"hg19,17:g.7579356G>T, hg19,17:g.7676038G>T, hg38,17:g.7676038G>T",,,0.517,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",836750,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.07735,1.173503279685974,2.25204,1.4575034278771166,1.664695,1.2674267139385584,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.93,E,-0.1505,1.0662,-8.8609,-3.546138403816,0.6099948176751155,Uncertain,0.3444,ambiguous,-3.738,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L111N,NP_000537:p.Leu111Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.43662,3.076674699783325,3.89218,2.8572817406964672,3.6644,3.146950870348234,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.93,E,-0.3888,1.0662,-22.1488,-6.86455845713059,0.870835939386577,Pathogenic,0.9897,pathogenic,-4.54,available,https://doi.org/10.1101/2022.10.22.513328 +L111P,NP_000537:p.Leu111Pro,"hg19,17:g.7579355A>G, hg19,17:g.7676037A>G, hg38,17:g.7676037A>G",,,0.864,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376630,Pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.83572,2.79578185081482,4.45544,5.778931198293195,4.14558,4.807325599146598,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.93,E,-0.4043,1.0662,-22.1488,-6.86455845713059,0.8690481369733514,Pathogenic,0.9584,pathogenic,-4.356,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L111Q,NP_000537:p.Leu111Gln,"hg19,17:g.7579355A>T, hg19,17:g.7676037A>T, hg38,17:g.7676037A>T",,,0.869,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376632,Pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.18527,2.872114896774292,3.79966,2.6371088762009864,3.992465,3.411189438100493,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.93,E,-0.3417,1.0662,-22.1488,-6.86455845713059,0.8668508225734014,Pathogenic,0.9593,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L111R,NP_000537:p.Leu111Arg,"hg19,17:g.7579355A>C, hg19,17:g.7676037A>C, hg38,17:g.7676037A>C",,,0.862,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376631,Pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.8654,3.213672637939453,7.51463,3.42587149400154,6.690015000000001,4.64563574700077,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.93,E,-0.4011,1.0662,-22.1488,-6.86455845713059,0.868284874800753,Pathogenic,0.9601,pathogenic,-4.569,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L111S,NP_000537:p.Leu111Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.03387,2.774970054626465,4.67823,3.790794997138844,4.85605,4.412332498569422,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.93,E,-0.3513,1.0662,-22.1488,-6.40292243487766,0.8387887677406434,Pathogenic,0.9683,pathogenic,-4.282,available,https://doi.org/10.1101/2022.10.22.513328 +L111T,NP_000537:p.Leu111Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.00231,2.135767936706543,3.18435,2.9027898633357085,3.59333,3.4525499316678543,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.93,E,-0.3241,1.0662,-22.1488,-6.40292243487766,0.868925185644946,Pathogenic,0.7846,pathogenic,-4.298,available,https://doi.org/10.1101/2022.10.22.513328 +L111V,NP_000537:p.Leu111Val,"hg19,17:g.7579356G>C, hg38,17:g.7676038G>C",,,0.456,"cBioPortal,ClinVar,saturation_mutlist",1730178,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.47432,0.6575518846511841,1.70306,1.7704684404902415,2.08869,2.1223942202451207,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.93,E,-0.1219,1.0662,-0.7012,-0.706742687105901,0.0008972384760983,Benign,0.1396,benign,-3.174,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L111W,NP_000537:p.Leu111Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.58201,2.311218976974488,6.08197,2.160503332527326,7.33199,5.371256666263664,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.93,E,-0.2857,1.0662,-8.8609,-6.0104303210959,0.8700690831624835,Pathogenic,0.9219,pathogenic,-4.531,available,https://doi.org/10.1101/2022.10.22.513328 +L111Y,NP_000537:p.Leu111Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.42066,2.376567840576172,4.22755,1.996572384897897,5.824104999999999,4.7086161924489485,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.102,,,,,,,,,2.0,,False,2.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.93,E,-0.3464,1.0662,-22.1488,-6.0104303210959,0.5966286451681089,Uncertain,0.961,pathogenic,-4.182,available,https://doi.org/10.1101/2022.10.22.513328 +G112A,NP_000537:p.Gly112Ala,"hg19,17:g.7579352C>G, hg38,17:g.7676034C>G",,3.9801311851e-06,,"ClinVar,saturation_mutlist",3634433,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.32971,0.8644964098930359,-0.22177,0.3633384852228211,-0.27574,0.01681424261141054,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.0865,2.296,-5.4016,-0.899611897453184,1.2002245120436748e-05,Benign,0.1727,benign,-3.022,available,https://doi.org/10.1101/2022.10.22.513328 +G112C,NP_000537:p.Gly112Cys,"hg38,17:g.7676035C>A",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.0524,0.3465752601623535,0.3949,0.9184895871334494,0.17124999999999999,0.4330447935667247,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.1639,2.296,-8.8609,-1.53299814309711,0.0069231742776907,Benign,0.3776,ambiguous,-3.4,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G112D,NP_000537:p.Gly112Asp,"hg19,17:g.7579352C>T, hg38,17:g.7676034C>T",,,,"COSMIC,ClinVar,saturation_mutlist",1319402,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.47137,1.3843066692352295,-1.1017,0.9053280498212152,-0.3151649999999999,0.6883490249106076,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.1644,2.296,-8.8609,-0.99843218722014,0.002859383904651,Benign,0.4302,ambiguous,-3.214,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G112E,NP_000537:p.Gly112Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.06005,1.1957354545593262,-0.17687,0.7293935620279742,-0.058410000000000004,0.39472178101398714,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.1475,2.296,-5.6912,-0.972571240468379,1.0744537158384177e-05,Benign,0.3726,ambiguous,-2.97,available,https://doi.org/10.1101/2022.10.22.513328 +G112F,NP_000537:p.Gly112Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.10274,0.6901378035545349,0.92007,-0.6949623157030399,-0.091335,-0.8988511578515199,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.2698,2.296,-22.1488,-3.64131977785257,0.1213689325946569,Benign,0.8513,pathogenic,-3.496,available,https://doi.org/10.1101/2022.10.22.513328 +G112H,NP_000537:p.Gly112His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.65528,0.97646301984787,0.08844,-0.2761212131467361,0.37185999999999997,0.18957939342663194,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.1624,2.296,-6.0537,-1.24042594624844,5.36044749340184e-05,Benign,0.6198,pathogenic,-3.096,available,https://doi.org/10.1101/2022.10.22.513328 +G112I,NP_000537:p.Gly112Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.85675,0.910146951675415,2.09082,0.7023038297307457,1.973785,1.2795269148653727,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.2477,2.296,-8.8609,-1.97476964754266,0.0563689126427347,Benign,0.6777,pathogenic,-3.468,available,https://doi.org/10.1101/2022.10.22.513328 +G112K,NP_000537:p.Gly112Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.76998,0.9967175126075744,0.2119,0.2537474256013255,-0.27904,-0.2581162871993372,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.2645,2.296,-22.1488,-3.40476128288232,0.0532011834913324,Benign,0.7159,pathogenic,-3.396,available,https://doi.org/10.1101/2022.10.22.513328 +G112L,NP_000537:p.Gly112Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.18247,0.5774756073951721,1.51429,-0.5058354471425208,0.16591,-0.8441527235712604,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.2108,2.296,-7.861,-2.17465468819708,0.0105016354956487,Benign,0.7101,pathogenic,-3.35,available,https://doi.org/10.1101/2022.10.22.513328 +G112M,NP_000537:p.Gly112Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.60026,0.6188175678253174,-0.43469,-0.2892663273294599,-0.517475,-0.44476316366472995,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.2219,2.296,-22.1488,-3.57929652606347,0.1868941824370333,Benign,0.7509,pathogenic,-3.577,available,https://doi.org/10.1101/2022.10.22.513328 +G112N,NP_000537:p.Gly112Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.05706,1.1902093887329102,-1.11156,0.2987370608344902,-0.5843100000000001,0.1208385304172451,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.2325,2.296,-22.1488,-2.88514049624978,0.0230560628824044,Benign,0.5211,ambiguous,-3.154,available,https://doi.org/10.1101/2022.10.22.513328 +G112P,NP_000537:p.Gly112Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.2336,2.5274734497070312,3.71735,5.746887567536878,3.4754750000000003,4.490243783768439,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.3296,2.296,-22.1488,-5.02558159316508,0.4318180680706053,Uncertain,0.9818,pathogenic,-3.762,available,https://doi.org/10.1101/2022.10.22.513328 +G112Q,NP_000537:p.Gly112Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.06247,0.9424679279327391,-0.3017,0.2494789430115618,-0.182085,0.0935044715057809,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.1574,2.296,-6.8611,-1.84916558188363,0.0007626764636442,Benign,0.4666,ambiguous,-3.201,available,https://doi.org/10.1101/2022.10.22.513328 +G112R,NP_000537:p.Gly112Arg,"hg19,17:g.7579353C>G",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.3743,1.0302342176437378,-0.24252,-0.3445500408352148,-0.30841,-0.3594250204176074,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.151,2.296,-3.0537,-1.653371145859,4.8060033505685386e-05,Benign,0.5622,ambiguous,-3.004,available,https://doi.org/10.1101/2022.10.22.513328 +G112S,NP_000537:p.Gly112Ser,"hg19,17:g.7579353C>T, hg38,17:g.7676035C>T",,3.9798777382e-06,,"COSMIC,ClinVar,saturation_mutlist",492575,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.54109,0.8052547574043274,0.0585,0.7533529829949959,0.299795,0.6472214914974979,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.0705,2.296,-1.1129,0.334341221521181,0.0001093374070058,Benign,0.1593,benign,-3.016,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G112T,NP_000537:p.Gly112Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.20578,0.9219362735748292,0.22245,0.8896318263426856,0.714115,1.0477059131713429,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.1555,2.296,-2.6912,-1.2332696351093,0.0065021426021602,Benign,0.3364,benign,-3.16,available,https://doi.org/10.1101/2022.10.22.513328 +G112V,NP_000537:p.Gly112Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.97477,0.960036039352417,1.44048,0.7216178164797645,1.207625,0.8481939082398823,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.1777,2.296,-6.2761,-1.89898999348958,0.0008182552398676,Benign,0.5033,ambiguous,-3.14,available,https://doi.org/10.1101/2022.10.22.513328 +G112W,NP_000537:p.Gly112Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.86318,0.9888739585876464,0.26701,-0.9256291510989472,-0.29808499999999993,-0.8944045755494736,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.2696,2.296,-22.1488,-4.05326500530896,0.482051244244269,Uncertain,0.8065,pathogenic,-3.776,available,https://doi.org/10.1101/2022.10.22.513328 +G112Y,NP_000537:p.Gly112Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.10828,0.916771113872528,0.63946,-0.5408371962016462,-0.23440999999999995,-0.824558598100823,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.134,,,Uncertain,,Uncertain,,,Uncertain,43.2,,False,43.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.29,E,-0.2702,2.296,-22.1488,-3.29481640589807,0.196935547244575,Benign,0.755,pathogenic,-3.519,available,https://doi.org/10.1101/2022.10.22.513328 +F113A,NP_000537:p.Phe113Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.16727,2.843000650405884,3.24388,4.259539378685558,4.205575,4.713404689342779,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.4468,0.0223,-22.1457,-6.13349417321062,0.8703769787118026,Pathogenic,0.9963,pathogenic,-4.258,available,https://doi.org/10.1101/2022.10.22.513328 +F113C,NP_000537:p.Phe113Cys,"hg19,17:g.7579349A>C, hg19,17:g.7676031A>C, hg38,17:g.7676030_7676031delinsAC, hg38,17:g.7676031A>C",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634690,Pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.98778,1.4255517721176147,3.67925,4.460821881585579,3.8335150000000002,4.224300940792789,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.4149,0.0223,-22.1457,-5.3182039737857,0.354722584704024,Uncertain,0.9677,pathogenic,-3.968,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113D,NP_000537:p.Phe113Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.01376,3.343472003936768,5.56905,5.234538647556071,5.791405,5.624149323778036,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.5697,0.0223,-22.1457,-7.21795550754685,0.8702116174010466,Pathogenic,0.9985,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +F113E,NP_000537:p.Phe113Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.26647,3.236279964447021,5.49048,4.805467544311604,5.378475,5.035968772155802,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.5391,0.0223,-22.1457,-7.21795550754685,0.869092078893722,Pathogenic,0.9989,pathogenic,-4.374,available,https://doi.org/10.1101/2022.10.22.513328 +F113G,NP_000537:p.Phe113Gly,"hg19,17:g.7579349_7579350delinsCC",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.77346,2.5650525093078613,4.46599,5.842294281013574,5.119725,5.807877140506787,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.4821,0.0223,-22.1457,-7.21795550754685,0.8666329317367638,Pathogenic,0.9967,pathogenic,-4.458,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113H,NP_000537:p.Phe113His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.77816,2.1967010498046875,2.61871,2.534944479282958,2.698435,2.656552239641479,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.4743,0.0223,-22.1457,-4.35311958943548,0.8533267010813845,Pathogenic,0.9927,pathogenic,-4.273,available,https://doi.org/10.1101/2022.10.22.513328 +F113I,NP_000537:p.Phe113Ile,"hg19,17:g.7579350A>T, hg38,17:g.7676032A>T",,,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1469551,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.88643,2.260878562927246,4.35578,2.865912250317298,4.121105,3.376171125158649,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.3907,0.0223,-22.1457,-4.62039939052872,0.3471698875702665,Uncertain,0.9262,pathogenic,-3.762,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113K,NP_000537:p.Phe113Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.62473,2.555844783782959,5.06837,4.835518798987956,4.84655,4.7301243994939774,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.546,0.0223,-22.1457,-7.21795550754685,0.865669254264934,Pathogenic,0.9988,pathogenic,-4.457,available,https://doi.org/10.1101/2022.10.22.513328 +F113L,NP_000537:p.Phe113Leu,"hg19,17:g.7579348G>C, hg19,17:g.7579348G>T, hg19,17:g.7579350A>G, hg19,17:g.7676030G>C, hg19,17:g.7676032A>G, hg38,17:g.7676030G>C, hg38,17:g.7676030G>T, hg38,17:g.7676032A>G",,,0.783,"cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","3634432, 2702402, 2125367","Pathogenic, Pathogenic, Likely pathogenic","1, 1, 1",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.4587,1.7532540559768677,2.4619,2.3963827226731027,2.4603,2.4275413613365515,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.3528,0.0223,-22.1457,-4.5916909414059,0.0721449101098672,Benign,0.9964,pathogenic,-3.566,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113M,NP_000537:p.Phe113Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.35823,1.944449663162232,2.43129,2.421890947480383,1.8947600000000002,1.8900604737401916,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.3838,0.0223,-22.1457,-4.43205180315152,0.6727790722939497,Uncertain,0.9767,pathogenic,-3.973,available,https://doi.org/10.1101/2022.10.22.513328 +F113N,NP_000537:p.Phe113Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.3624,2.649327516555786,3.78061,4.088910645802889,4.071505,4.225655322901444,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.4994,0.0223,-22.1457,-7.21795550754685,0.8689550152710639,Pathogenic,0.9951,pathogenic,-4.398,available,https://doi.org/10.1101/2022.10.22.513328 +F113P,NP_000537:p.Phe113Pro,"hg19,17:g.7579348_7579350delinsAGG, hg38,17:g.7676030_7676032delinsAGG",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.31033,2.7431414127349854,5.8102,7.506102633034775,6.060265,6.908216316517388,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.5701,0.0223,-22.1457,-7.21795550754685,0.8340828889646085,Pathogenic,0.9993,pathogenic,-4.192,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113Q,NP_000537:p.Phe113Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.25101,2.89392614364624,3.87619,4.0364242939376265,4.0636,4.143717146968813,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.5015,0.0223,-22.1457,-7.21795550754685,0.862445849618718,Pathogenic,0.9976,pathogenic,-4.157,available,https://doi.org/10.1101/2022.10.22.513328 +F113R,NP_000537:p.Phe113Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.54683,2.458667278289795,5.08265,3.851501413094237,5.3147400000000005,4.699165706547118,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.5474,0.0223,-22.1457,-7.21795550754685,0.8681372247955081,Pathogenic,0.9966,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328 +F113S,NP_000537:p.Phe113Ser,"hg19,17:g.7579349A>G, hg19,17:g.7676031A>G, hg38,17:g.7676031A>G",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",823709,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.38886,2.840721368789673,3.99524,4.9753630985168895,4.19205,4.682111549258445,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.4258,0.0223,-22.1457,-6.13349417321062,0.8695796678637897,Pathogenic,0.9952,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113T,NP_000537:p.Phe113Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.50835,2.941203355789185,3.69456,4.1971780170555775,3.601455,3.8527640085277888,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.472,0.0223,-22.1457,-6.13349417321062,0.8597742127206307,Pathogenic,0.9968,pathogenic,-4.306,available,https://doi.org/10.1101/2022.10.22.513328 +F113V,NP_000537:p.Phe113Val,"hg19,17:g.7579350A>C, hg19,17:g.7676032A>C, hg38,17:g.7676032A>C",,,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141302,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.35096,2.4748764038085938,3.96633,3.1756072520071714,4.158645,3.7632836260035853,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.14,-,-0.385,0.0223,-22.1457,-5.04973460316859,0.2938139973777304,Benign,0.9446,pathogenic,-3.778,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F113W,NP_000537:p.Phe113Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.24272,1.3182365894317627,0.42823,0.8905888349916088,0.835475,1.0666544174958044,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,-,-0.3025,0.0223,-8.8578,-2.6540479440965,0.6412423681462546,Uncertain,0.9397,pathogenic,-4.053,available,https://doi.org/10.1101/2022.10.22.513328 +F113Y,NP_000537:p.Phe113Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.11793,1.1865521669387815,0.67721,0.8148151572725959,1.39757,1.4663725786362978,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.107,,,,,,,,,7.1,,False,7.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.14,-,-0.3386,0.0223,-22.1457,-4.23850217988098,0.8305176799224958,Pathogenic,0.8085,pathogenic,-3.79,available,https://doi.org/10.1101/2022.10.22.513328 +L114A,NP_000537:p.Leu114Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.23838,0.2932223677635193,0.52211,0.7488831219041214,0.380245,0.49363156095206073,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.3061,1.2277,-22.1457,-3.02147339813199,0.0922607492949681,Benign,0.4215,ambiguous,-3.444,available,https://doi.org/10.1101/2022.10.22.513328 +L114C,NP_000537:p.Leu114Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.45659,-0.0231443047523498,0.24014,1.4952286120581106,0.348365,0.9759093060290553,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.2953,1.2277,-22.1457,-3.61918334445075,0.4377881291385662,Uncertain,0.6481,pathogenic,-3.647,available,https://doi.org/10.1101/2022.10.22.513328 +L114D,NP_000537:p.Leu114Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.56971,0.1824069023132324,1.42177,0.6445098251100961,0.9957400000000001,0.6071099125550481,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.4276,1.2277,-22.1457,-2.31518817363431,0.0651642286155228,Benign,0.8617,pathogenic,-3.4,available,https://doi.org/10.1101/2022.10.22.513328 +L114E,NP_000537:p.Leu114Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.21379,0.3183484077453613,0.85374,0.468616908999746,0.533765,0.341203454499873,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.3117,1.2277,-5.688,-1.38574124110082,0.0002346572355485,Benign,0.5565,ambiguous,-3.014,available,https://doi.org/10.1101/2022.10.22.513328 +L114F,NP_000537:p.Leu114Phe,"hg19,17:g.7579345C>A, hg19,17:g.7579345C>G, hg38,17:g.7676027C>A",,3.980986807e-06,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.39664,0.0332525968551635,0.40646,0.4270104295558163,0.004909999999999998,0.015185214777908157,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.2395,1.2277,-22.1457,-4.11368345820104,0.557200039113269,Uncertain,0.2723,benign,-3.771,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L114G,NP_000537:p.Leu114Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.58046,0.6450505256652832,1.68605,1.6691540436215293,1.1332550000000001,1.1248070218107646,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.3809,1.2277,-22.1457,-3.69591548065688,0.0404722366865803,Benign,0.6798,pathogenic,-3.37,available,https://doi.org/10.1101/2022.10.22.513328 +L114H,NP_000537:p.Leu114His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.82676,0.1036744713783264,0.66667,0.3717506767817075,0.746715,0.5992553383908538,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.2726,1.2277,-7.273,-2.79011641652625,0.0036799364687273,Benign,0.3797,ambiguous,-3.302,available,https://doi.org/10.1101/2022.10.22.513328 +L114I,NP_000537:p.Leu114Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14896,0.1142377853393554,-0.11259,0.1174831112042285,0.018185000000000007,0.13322155560211424,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.15,-,-0.1124,1.2277,-8.8578,-0.345807039189694,0.1959178756992446,Benign,0.1441,benign,-3.488,available,https://doi.org/10.1101/2022.10.22.513328 +L114K,NP_000537:p.Leu114Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.03831,0.2723428010940552,0.44694,0.4822939448904367,0.204315,0.22199197244521834,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.15,-,-0.3947,1.2277,-22.1457,-3.01079486307124,0.002740076722145,Benign,0.5153,ambiguous,-3.454,available,https://doi.org/10.1101/2022.10.22.513328 +L114M,NP_000537:p.Leu114Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.3678,0.2487517595291137,-0.22245,0.4865173891577745,-0.295125,0.05935869457888723,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.15,-,-0.2035,1.2277,-22.1457,-3.63992464586932,0.5701816960720417,Uncertain,0.1838,benign,-3.63,available,https://doi.org/10.1101/2022.10.22.513328 +L114N,NP_000537:p.Leu114Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.69109,0.1478816270828247,0.84966,0.7745010558921569,0.770375,0.7327955279460785,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.2918,1.2277,-6.0506,-1.37982099473904,0.0013152254315917,Benign,0.5681,pathogenic,-3.278,available,https://doi.org/10.1101/2022.10.22.513328 +L114P,NP_000537:p.Leu114Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.79773,-0.1294752359390258,1.07279,1.9747251170093727,0.13752999999999993,0.5884975585046863,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.304,1.2277,-5.3985,-2.05794352549244,0.0002029865377321,Benign,0.3056,benign,-3.202,available,https://doi.org/10.1101/2022.10.22.513328 +L114Q,NP_000537:p.Leu114Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01228,0.4187955856323242,0.04898,0.6879055204305257,0.01835,0.33781276021526285,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.216,1.2277,-0.4234,-0.963111150646381,3.340247947338193e-07,Benign,0.2211,benign,-2.894,available,https://doi.org/10.1101/2022.10.22.513328 +L114R,NP_000537:p.Leu114Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.067,0.2423750758171081,0.7085,0.3762996156024417,0.38775000000000004,0.22164980780122084,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.3185,1.2277,-8.8578,-2.51852481255318,0.0044504030389418,Benign,0.3325,benign,-3.324,available,https://doi.org/10.1101/2022.10.22.513328 +L114S,NP_000537:p.Leu114Ser,"hg19,17:g.7579346A>G, hg38,17:g.7676028A>G",,3.9802896059e-06,,"ClinVar,saturation_mutlist",458536,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.40896,0.2539994716644287,0.8398,0.7867079202526475,0.6243799999999999,0.5978339601263237,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.3365,1.2277,-22.1457,-3.11324781431236,0.0209766339057478,Benign,0.4267,ambiguous,-3.336,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L114T,NP_000537:p.Leu114Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.6453,0.2812762856483459,0.47959,0.6739058422128649,0.562445,0.6596029211064325,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.2363,1.2277,-7.8579,-2.29240328586287,0.0030058673369745,Benign,0.375,ambiguous,-3.283,available,https://doi.org/10.1101/2022.10.22.513328 +L114V,NP_000537:p.Leu114Val,"hg19,17:g.7579347A>C, hg38,17:g.7676029A>C",,,0.573,"ClinVar,saturation_mutlist",1011474,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.54637,0.236601173877716,-0.06395,0.317018910451865,0.24121,0.4316944552259325,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.1487,1.2277,-8.8578,-2.82763989652406,0.1547529500998032,Benign,0.1575,benign,-3.364,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L114W,NP_000537:p.Leu114Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.03638,0.0737360119819641,0.5881,0.0028172170124218,0.31223999999999996,0.019598608506210903,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.3387,1.2277,-22.1457,-4.46690504695434,0.5531482661432023,Uncertain,0.4845,ambiguous,-3.851,available,https://doi.org/10.1101/2022.10.22.513328 +L114Y,NP_000537:p.Leu114Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.87941,0.0400596857070922,0.04286,0.405115885214054,-0.418275,-0.237147057392973,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,Uncertain,,Uncertain,,,Uncertain,63.2,,False,63.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.15,-,-0.3316,1.2277,-22.1457,-4.26309926818903,0.4611170891989466,Uncertain,0.6318,pathogenic,-3.658,available,https://doi.org/10.1101/2022.10.22.513328 +H115A,NP_000537:p.His115Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.15143,0.124734878540039,0.34388,0.1074068315965331,0.24765500000000001,0.12941841579826655,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.1125,1.2631,-8.8578,-2.49871178402455,0.0003245250112844,Benign,0.1469,benign,-3.114,available,https://doi.org/10.1101/2022.10.22.513328 +H115C,NP_000537:p.His115Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.30479,0.0308828949928283,0.4881,0.9007320959186418,0.09165499999999999,0.2979710479593209,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.2349,1.2631,-22.1457,-3.74325866775051,0.0018230464683667,Benign,0.1408,benign,-3.384,available,https://doi.org/10.1101/2022.10.22.513328 +H115D,NP_000537:p.His115Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.86314,0.0996827483177185,-1.43401,-0.1975500899001087,-1.1485750000000001,-0.5303450449500544,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.2276,1.2631,-22.1457,-1.40673083084263,2.887410857536157e-06,Benign,0.1065,benign,-3.056,available,https://doi.org/10.1101/2022.10.22.513328 +H115E,NP_000537:p.His115Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.50321,0.246038556098938,-0.08673,-0.2268672026505303,-0.29497,-0.36503860132526517,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.1632,1.2631,-7.273,-0.909469237543317,9.00066842915454e-08,Benign,0.1491,benign,-2.845,available,https://doi.org/10.1101/2022.10.22.513328 +H115F,NP_000537:p.His115Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.27368,0.2603118419647217,-0.83435,0.0334436028800494,-0.554015,-0.1201181985599753,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.202,1.2631,-22.1457,-3.60121260300351,0.0029691475110697,Benign,0.3412,ambiguous,-3.498,available,https://doi.org/10.1101/2022.10.22.513328 +H115G,NP_000537:p.His115Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.14638,0.6215373277664185,1.01054,0.5550702615508359,0.43208,0.20434513077541797,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.2629,1.2631,-22.1457,-4.25156140938952,0.0007022105094633,Benign,0.1632,benign,-3.181,available,https://doi.org/10.1101/2022.10.22.513328 +H115I,NP_000537:p.His115Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.09759,0.0963547229766845,-1.32415,-0.002744254465517,-0.6132799999999999,0.0474228727672415,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.1988,1.2631,-8.8578,-3.21877729587408,0.0060322700694805,Benign,0.2678,benign,-3.524,available,https://doi.org/10.1101/2022.10.22.513328 +H115K,NP_000537:p.His115Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.36775,0.1468647122383117,-0.10272,-0.0959977149853935,-0.23523500000000003,-0.23187385749269676,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.128,1.2631,-3.4657,-0.71613825039974,3.875358886704338e-08,Benign,0.14,benign,-2.916,available,https://doi.org/10.1101/2022.10.22.513328 +H115L,NP_000537:p.His115Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2667,0.1611461043357849,-1.11259,-0.2618376799729488,-0.689645,-0.26426883998647444,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.2302,1.2631,-22.1457,-4.8353305868595,0.0083582120182901,Benign,0.1167,benign,-3.47,available,https://doi.org/10.1101/2022.10.22.513328 +H115M,NP_000537:p.His115Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.39026,0.3470137119293213,-1.00578,0.0281101881391404,-0.69802,-0.1810749059304298,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.1803,1.2631,-22.1457,-4.8353305868595,0.0437260673551567,Benign,0.363,ambiguous,-3.534,available,https://doi.org/10.1101/2022.10.22.513328 +H115N,NP_000537:p.His115Asn,"hg19,17:g.7579344G>T, hg38,17:g.7676026G>T",,,,"ClinVar,saturation_mutlist",480741,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.4101,0.0312401056289672,-0.09116,-0.0618528594499012,-0.25063,-0.23597642972495061,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.0998,1.2631,-5.0506,0.308822816233988,5.974850187780796e-08,Benign,0.059,benign,-2.824,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H115P,NP_000537:p.His115Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.40477,0.3409227132797241,-0.12177,0.2328801438239891,-0.26327,-0.08594492808800545,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.2677,1.2631,-7.273,-2.13513398079854,7.85116973659687e-07,Benign,0.0802,benign,-2.95,available,https://doi.org/10.1101/2022.10.22.513328 +H115Q,NP_000537:p.His115Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15977,0.2000414729118347,-0.48299,0.1403639523417049,-0.32138,-0.009703023829147547,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.0376,1.2631,-0.3945,0.28798040500391,1.1311714008605628e-15,Benign,0.0936,benign,-2.689,available,https://doi.org/10.1101/2022.10.22.513328 +H115R,NP_000537:p.His115Arg,"hg19,17:g.7579343T>C, hg38,17:g.7676025T>C",,,0.484,"ClinVar,saturation_mutlist",182925,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2739,0.1556218862533569,0.23367,-0.1495098438082942,-0.020114999999999994,-0.21170492190414708,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.1489,1.2631,-8.8578,-0.639219997941988,0.0034631911295987,Benign,0.0837,benign,-3.186,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H115S,NP_000537:p.His115Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.04523,0.0841977596282959,0.10578,0.0410559556385986,0.075505,0.0431429778192993,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.1863,1.2631,-22.1457,-3.02281899931621,6.736528986214677e-05,Benign,0.1089,benign,-3.01,available,https://doi.org/10.1101/2022.10.22.513328 +H115T,NP_000537:p.His115Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.08777,0.2486981749534607,-0.0415,0.0178089831001621,0.023135,0.05278949155008105,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.1633,1.2631,-8.8578,-2.96321283812971,1.3846378687659026e-05,Benign,0.1342,benign,-3.031,available,https://doi.org/10.1101/2022.10.22.513328 +H115V,NP_000537:p.His115Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.19227,0.133630633354187,-0.59116,0.0610455371324608,-0.199445,0.1266577685662304,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.223,1.2631,-22.1457,-4.8353305868595,0.0027855934757054,Benign,0.1977,benign,-3.326,available,https://doi.org/10.1101/2022.10.22.513328 +H115W,NP_000537:p.His115Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.49069,0.2164300680160522,-0.16054,-0.3084362722297357,-0.325615,-0.3995631361148678,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.2182,1.2631,-22.1457,-3.60121260300351,0.0256810906046774,Benign,0.3966,ambiguous,-3.702,available,https://doi.org/10.1101/2022.10.22.513328 +H115Y,NP_000537:p.His115Tyr,"hg19,17:g.7579344G>A, hg38,17:g.7676026G>A",,,0.517,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2408,0.1419579982757568,-0.97279,0.08547486210636,-0.606795,-0.07766256894682,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.063,,,Uncertain,,Uncertain,,,Uncertain,99.8,,False,99.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,88.03,-,-0.1522,1.2631,-22.1457,-3.31338370914593,0.0064119375148505,Benign,0.1234,benign,-3.38,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S116A,NP_000537:p.Ser116Ala,"hg19,17:g.7579341A>C, hg38,17:g.7676023A>C",,7.9620370075e-06,,"ClinVar,saturation_mutlist",649358,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.45035,0.1317556798458099,-0.25408,0.4861450778981652,-0.35221499999999994,0.01789753894908261,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,89.09,-,-0.1914,0.2264,-8.8578,-2.00341217169089,0.0413209143765034,Benign,0.1921,benign,-3.455,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S116C,NP_000537:p.Ser116Cys,"hg19,17:g.7579340G>C, hg38,17:g.7676022G>C",,,0.706,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.53419,-0.500048041343689,-0.11088,0.9028300032373454,-0.322535,0.18432000161867268,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.2419,0.2264,-8.8578,-2.45105725928614,0.3262575042509616,Uncertain,0.2552,benign,-3.764,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S116D,NP_000537:p.Ser116Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.09068,0.9312669634819032,-0.86054,1.0289928864247213,-0.38493,0.5598364432123607,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.3579,0.2264,-22.1457,-4.51569896990287,0.363969222951413,Uncertain,0.9092,pathogenic,-3.652,available,https://doi.org/10.1101/2022.10.22.513328 +S116E,NP_000537:p.Ser116Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.55416,0.0635057985782623,0.55272,1.0323565324217612,-0.0007199999999999984,0.2390982662108806,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.331,0.2264,-22.1457,-3.87953381312762,0.1612981074433769,Benign,0.9212,pathogenic,-3.553,available,https://doi.org/10.1101/2022.10.22.513328 +S116F,NP_000537:p.Ser116Phe,"hg19,17:g.7579340G>A, hg38,17:g.7676022G>A",,,0.728,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.38973,-0.2072300910949707,1.28537,-0.6919327037534356,-0.052180000000000004,-1.0408313518767178,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.2643,0.2264,-7.8579,-4.33430097327344,0.0420031375207094,Benign,0.6667,pathogenic,-3.809,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S116G,NP_000537:p.Ser116Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.4076,0.6380835175514221,0.31122,1.3660273334918118,0.35941,0.8868136667459059,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.2683,0.2264,-22.1457,-5.32337415423123,0.3883380802803214,Uncertain,0.2886,benign,-3.718,available,https://doi.org/10.1101/2022.10.22.513328 +S116H,NP_000537:p.Ser116His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.17009,-0.2921610474586487,0.72075,-0.1833496517505778,0.27533,-0.1767198258752889,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.3385,0.2264,-22.1457,-5.89550803007333,0.6801145930519357,Pathogenic,0.7848,pathogenic,-3.961,available,https://doi.org/10.1101/2022.10.22.513328 +S116I,NP_000537:p.Ser116Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.13402,-0.3780116438865661,2.85204,-0.0095706332258344,0.85901,-0.5717953166129172,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,2e-05,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.3404,0.2264,-22.1457,-6.12861430951413,0.8042692387320659,Pathogenic,0.7785,pathogenic,-4.162,available,https://doi.org/10.1101/2022.10.22.513328 +S116K,NP_000537:p.Ser116Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.80241,-0.3879529237747192,-0.00408,0.6994682006113684,-0.40324499999999996,-0.051470899694315786,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.3478,0.2264,-22.1457,-5.47217201295152,0.4881810707830208,Uncertain,0.9772,pathogenic,-3.774,available,https://doi.org/10.1101/2022.10.22.513328 +S116L,NP_000537:p.Ser116Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.05755,-0.6483463048934937,0.83741,-0.7178121152217848,-0.11007,-0.8876810576108924,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.3366,0.2264,-22.1457,-5.96281620325936,0.5155338775396696,Uncertain,0.4045,ambiguous,-3.915,available,https://doi.org/10.1101/2022.10.22.513328 +S116M,NP_000537:p.Ser116Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.09169,-0.5460889339447021,0.14048,-0.3160180628462822,-0.47560500000000006,-0.7038540314231412,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.3077,0.2264,-22.1457,-6.12861430951413,0.7829491194766001,Pathogenic,0.5745,pathogenic,-4.135,available,https://doi.org/10.1101/2022.10.22.513328 +S116N,NP_000537:p.Ser116Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.50273,0.1196363270282745,-1.17653,0.3472028156916029,-0.8396300000000001,-0.07776359215419856,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.2056,0.2264,-7.273,-3.01068707742963,0.0001062729721008,Benign,0.6127,pathogenic,-3.449,available,https://doi.org/10.1101/2022.10.22.513328 +S116P,NP_000537:p.Ser116Pro,"hg38,17:g.7676023A>G",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.44954,1.000367283821106,-1.4449,3.535244655286716,0.0023199999999999887,2.492392327643358,Neutral,Uncertain,Uncertain,Neutral,Uncertain,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.4126,0.2264,-22.1457,-4.16912442701375,0.4106374427540816,Uncertain,0.693,pathogenic,-3.616,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S116Q,NP_000537:p.Ser116Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.81442,-0.3103790879249573,-0.22381,0.7013676693017185,-0.519115,-0.05652616534914079,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.3011,0.2264,-22.1457,-4.19479262125623,0.1434728875251132,Benign,0.8732,pathogenic,-3.675,available,https://doi.org/10.1101/2022.10.22.513328 +S116R,NP_000537:p.Ser116Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.64306,-0.4930810928344726,-0.62143,-0.0663680332688237,-0.632245,-0.3547140166344118,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.353,0.2264,-22.1457,-6.17290934307554,0.727033203104112,Pathogenic,0.9606,pathogenic,-3.909,available,https://doi.org/10.1101/2022.10.22.513328 +S116T,NP_000537:p.Ser116Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.65357,-0.5250197649002075,-1.05476,0.6105385380956385,-0.854165,-0.021515730952180734,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,neutral,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.1702,0.2264,-6.536,-1.90732514580004,0.0011477361281229,Benign,0.1472,benign,-3.304,available,https://doi.org/10.1101/2022.10.22.513328 +S116V,NP_000537:p.Ser116Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.76563,-0.3994398117065429,-0.1466,0.184770622121797,-0.45611500000000005,-0.2904296889391015,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.3146,0.2264,-22.1457,-6.12861430951413,0.5244524006053052,Uncertain,0.6613,pathogenic,-3.904,available,https://doi.org/10.1101/2022.10.22.513328 +S116W,NP_000537:p.Ser116Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-2.61816,-0.0868169069290161,0.78605,-0.9737744993644792,-0.9160550000000001,-1.7959672496822396,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.3469,0.2264,-22.1457,-6.22404420658784,0.8518344951736576,Pathogenic,0.7456,pathogenic,-4.377,available,https://doi.org/10.1101/2022.10.22.513328 +S116Y,NP_000537:p.Ser116Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.29271,-0.2701494693756103,2.93946,-0.5439600347792789,0.823375,-0.9183350173896394,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,-0.00252,Neutral,,,Uncertain,39.2,,False,39.2,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,89.09,-,-0.342,0.2264,-22.1457,-6.22404420658784,0.8260139603137466,Pathogenic,0.6522,pathogenic,-4.125,available,https://doi.org/10.1101/2022.10.22.513328 +G117A,NP_000537:p.Gly117Ala,"hg19,17:g.7579337C>G, hg38,17:g.7676019C>G",,3.9826357083e-06,0.778,"cBioPortal,ClinVar,saturation_mutlist",1055289,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.88639,0.6192632913589478,0.19932,-0.502010862609712,1.042855,0.692189568695144,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.2944,0.9651,-22.1457,-3.3959861353324,0.5908429624479663,Uncertain,0.539,ambiguous,-3.786,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G117C,NP_000537:p.Gly117Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.37983,0.494555115699768,0.63946,0.1324965552952733,1.009645,0.7561632776476366,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.3541,0.9651,-22.1457,-3.12860849519928,0.8703854077951694,Pathogenic,0.8203,pathogenic,-4.176,available,https://doi.org/10.1101/2022.10.22.513328 +G117D,NP_000537:p.Gly117Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.71385,0.5283339023590088,0.14014,-0.6842537740705984,-0.28685499999999997,-0.6990518870352992,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,-0.00518,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.3547,0.9651,-22.1457,-4.01603996263716,0.4375203996695488,Uncertain,0.9325,pathogenic,-3.777,available,https://doi.org/10.1101/2022.10.22.513328 +G117E,NP_000537:p.Gly117Glu,"hg19,17:g.7579337C>T, hg38,17:g.7676019C>T",,3.9826357083e-06,0.784,"COSMIC,ClinVar,saturation_mutlist",2450745,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.15489,1.114114761352539,0.37619,-0.6304090777766547,0.76554,0.26224046111167265,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,-0.00324,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.354,0.9651,-22.1457,-3.5766581696358,0.4572631760483703,Uncertain,0.9517,pathogenic,-3.676,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G117F,NP_000537:p.Gly117Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.71868,1.314211130142212,1.30374,-0.7833314053768659,1.51121,0.46767429731156707,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.3922,0.9651,-22.1457,-4.97624722164543,0.7579089014217995,Pathogenic,0.9816,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328 +G117H,NP_000537:p.Gly117His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.08043,1.1155779361724854,0.59932,-0.784036046420698,1.339875,0.6481969767896509,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.367,0.9651,-22.1457,-5.10008891973465,0.8212544187948694,Pathogenic,0.95,pathogenic,-4.011,available,https://doi.org/10.1101/2022.10.22.513328 +G117I,NP_000537:p.Gly117Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.55473,1.4449301958084106,1.46599,-0.6016575318081174,1.51036,0.47653623409594126,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.4379,0.9651,-22.1457,-4.24782712338559,0.7459687017699442,Pathogenic,0.9577,pathogenic,-4.162,available,https://doi.org/10.1101/2022.10.22.513328 +G117K,NP_000537:p.Gly117Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.2596,1.3232001066207886,0.54116,-0.5255736441233472,0.40037999999999996,-0.1329868220616736,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.3869,0.9651,-22.1457,-3.09073133689788,0.2011288485694889,Benign,0.9665,pathogenic,-3.708,available,https://doi.org/10.1101/2022.10.22.513328 +G117L,NP_000537:p.Gly117Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.90876,1.4434436559677124,0.62041,-0.7461006287555566,1.264585,0.5813296856222216,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.3383,0.9651,-8.8578,-4.79960574611016,0.8317499693496002,Pathogenic,0.9558,pathogenic,-4.009,available,https://doi.org/10.1101/2022.10.22.513328 +G117M,NP_000537:p.Gly117Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.17881,1.3040053844451904,0.88912,-0.5066752805653391,1.033965,0.3360673597173304,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.3443,0.9651,-22.1457,-5.10611538046356,0.8661741284384346,Pathogenic,0.9644,pathogenic,-4.224,available,https://doi.org/10.1101/2022.10.22.513328 +G117N,NP_000537:p.Gly117Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.45122,0.6795254349708557,0.48537,-0.6126380093399963,0.468295,-0.08070900466999817,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.355,0.9651,-22.1457,-3.26156370406927,0.4156834673996206,Uncertain,0.8732,pathogenic,-3.732,available,https://doi.org/10.1101/2022.10.22.513328 +G117P,NP_000537:p.Gly117Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.17962,1.342210054397583,0.30442,1.1140109562195857,0.06240000000000001,0.46719547810979284,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.452,0.9651,-22.1457,-4.2175501024323,0.5705944880448508,Uncertain,0.9748,pathogenic,-3.683,available,https://doi.org/10.1101/2022.10.22.513328 +G117Q,NP_000537:p.Gly117Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.75608,1.2497644424438477,0.66599,-0.4101694444047915,1.211035,0.6729552777976043,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.3579,0.9651,-22.1457,-3.54294758527564,0.5485047926155499,Uncertain,0.9267,pathogenic,-3.762,available,https://doi.org/10.1101/2022.10.22.513328 +G117R,NP_000537:p.Gly117Arg,"hg19,17:g.7579338C>G, hg19,17:g.7579338C>T, hg38,17:g.7676020C>G, hg38,17:g.7676020C>T",,,0.770,"COSMIC,ClinVar,ClinVar,saturation_mutlist","1462102, 480758","Uncertain significance, Uncertain significance","2, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.42871,1.361948847770691,0.8915,-0.677657066963247,0.6601049999999999,-0.12447353348162352,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,-8e-05,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.3031,0.9651,-8.8578,-2.8438013983937,0.4603053800352202,Uncertain,0.9297,pathogenic,-3.894,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G117S,NP_000537:p.Gly117Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.43952,0.5420348644256592,-0.14014,-0.6032471864796923,0.14969000000000002,-0.08186359323984616,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.1904,0.9651,-0.6053,-1.26278959382385,1.977112976983445e-05,Benign,0.2758,benign,-3.102,available,https://doi.org/10.1101/2022.10.22.513328 +G117T,NP_000537:p.Gly117Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.87114,0.922194242477417,-0.14796,-0.5709416471588924,0.86159,0.6500991764205538,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.3772,0.9651,-22.1457,-2.60644894229147,0.7404866265029891,Pathogenic,0.663,pathogenic,-3.73,available,https://doi.org/10.1101/2022.10.22.513328 +G117V,NP_000537:p.Gly117Val,"hg19,17:g.7579337C>A, hg38,17:g.7676019C>A",,,0.832,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",837018,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.77863,1.3763203620910645,1.40714,-0.4562251026060399,1.5928849999999999,0.6612024486969801,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.3812,0.9651,-22.1457,-4.80793000393827,0.6298537946737008,Uncertain,0.8929,pathogenic,-3.926,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G117W,NP_000537:p.Gly117Trp,"hg19,17:g.7579338C>A",,,0.765,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.94737,1.0710797309875488,1.35204,-1.2123989381389444,1.649705,0.3674855309305278,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.392,0.9651,-22.1457,-5.2937022889525,0.8636206587384927,Pathogenic,0.9691,pathogenic,-4.43,available,https://doi.org/10.1101/2022.10.22.513328 +G117Y,NP_000537:p.Gly117Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.96899,1.3486270904541016,1.01361,-0.8136379961824564,1.4912999999999998,0.5776760019087719,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.026,,,Uncertain,0.0,Neutral,,,Uncertain,109.1,,False,109.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.98,-,-0.3926,0.9651,-22.1457,-5.2937022889525,0.8708630270092321,Pathogenic,0.9759,pathogenic,-4.257,available,https://doi.org/10.1101/2022.10.22.513328 +T118A,NP_000537:p.Thr118Ala,"hg38,17:g.7676017T>C",,,0.842,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.2555,0.6396656036376953,-1.49864,0.2216507095811681,-0.62157,0.23857535479058406,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.00313,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,92.31,-,-0.2351,0.2115,-8.8578,-3.04870572018323,0.3266723516664855,Uncertain,0.3644,ambiguous,-3.481,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T118C,NP_000537:p.Thr118Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.49004,0.2646440267562866,1.42857,0.5142472884325174,0.959305,0.5021436442162587,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,-0.0005,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,92.31,-,-0.2709,0.2115,-8.8578,-4.11340270861261,0.3092550607421923,Benign,0.8132,pathogenic,-3.698,available,https://doi.org/10.1101/2022.10.22.513328 +T118D,NP_000537:p.Thr118Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.27988,0.4513272643089294,0.17075,0.3852395792713642,0.22531500000000002,0.3325597896356821,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,-0.08793,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,92.31,-,-0.4184,0.2115,-22.1457,-4.87423631104636,0.6555365309182115,Uncertain,0.9499,pathogenic,-3.931,available,https://doi.org/10.1101/2022.10.22.513328 +T118E,NP_000537:p.Thr118Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.66461,0.4968498349189758,1.18197,0.1222760110070442,0.9232899999999999,0.3934430055035221,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,-0.04404,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,92.31,-,-0.3938,0.2115,-22.1457,-4.13703358370453,0.4330246415171949,Uncertain,0.8606,pathogenic,-3.738,available,https://doi.org/10.1101/2022.10.22.513328 +T118F,NP_000537:p.Thr118Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14634,0.6947311162948608,0.79422,-0.5211669575451955,0.47028000000000003,-0.18741347877259773,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,-0.00134,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,92.31,-,-0.4101,0.2115,-22.1457,-6.58689514793135,0.6325050489892905,Uncertain,0.7931,pathogenic,-4.212,available,https://doi.org/10.1101/2022.10.22.513328 +T118G,NP_000537:p.Thr118Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.8332,0.9441715478897096,2.29864,1.279667064907552,1.56592,1.0564335324537761,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.00974,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,92.31,-,-0.3085,0.2115,-8.8578,-6.02911580137211,0.5660702432296895,Uncertain,0.779,pathogenic,-3.777,available,https://doi.org/10.1101/2022.10.22.513328 +T118H,NP_000537:p.Thr118His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.89479,0.7130352854728699,0.11429,-0.2013757587401943,0.50454,0.34670712062990283,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.00052,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,92.31,-,-0.3904,0.2115,-22.1457,-6.58689514793135,0.6272129784997521,Uncertain,0.842,pathogenic,-3.947,available,https://doi.org/10.1101/2022.10.22.513328 +T118I,NP_000537:p.Thr118Ile,"hg19,17:g.7579334G>A, hg38,17:g.7676016G>A",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",419837,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.1738,0.7830296158790588,0.41156,-0.504226791748128,0.29268,-0.165213395874064,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,-0.00029,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,92.31,-,-0.2609,0.2115,-8.8578,-3.94190866086847,0.0830332885993737,Benign,0.7032,pathogenic,-3.632,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T118K,NP_000537:p.Thr118Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.10099,1.364171862602234,1.04252,0.0923205342509708,0.5717549999999999,0.09665526712548539,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.036,,,Uncertain,0.09842,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,92.31,-,-0.386,0.2115,-22.1457,-4.95721027156549,0.4408627011101784,Uncertain,0.7421,pathogenic,-3.764,available,https://doi.org/10.1101/2022.10.22.513328 +T118L,NP_000537:p.Thr118Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.74413,0.729701578617096,0.29626,-0.8008844496753043,-0.22393499999999997,-0.7725072248376521,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,-0.01279,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,92.31,-,-0.3807,0.2115,-22.1457,-4.88215407172758,0.7203214651696899,Pathogenic,0.3972,ambiguous,-3.842,available,https://doi.org/10.1101/2022.10.22.513328 +T118M,NP_000537:p.Thr118Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.72439,0.8116624355316162,0.53878,-0.4381633343980523,-0.09280499999999997,-0.5812766671990262,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.01003,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,92.31,-,-0.2717,0.2115,-7.273,-3.72087269096659,0.0587873814959232,Benign,0.2056,benign,-3.619,available,https://doi.org/10.1101/2022.10.22.513328 +T118N,NP_000537:p.Thr118Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.32886,0.604252278804779,0.54116,0.0438394211984249,0.43501,0.18634971059921243,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,92.31,-,-0.3585,0.2115,-22.1457,-3.90496608430963,0.4228189985131486,Uncertain,0.6829,pathogenic,-3.692,available,https://doi.org/10.1101/2022.10.22.513328 +T118P,NP_000537:p.Thr118Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.8521,1.1989388465881348,1.48367,1.4863451499289744,1.167885,1.1692225749644871,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.036,,,Uncertain,0.00562,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,92.31,-,-0.4672,0.2115,-22.1457,-5.02384101005698,0.5585502143103667,Uncertain,0.5204,ambiguous,-3.788,available,https://doi.org/10.1101/2022.10.22.513328 +T118Q,NP_000537:p.Thr118Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.4209,0.8091869354248047,0.86361,0.0057305789568218,0.642255,0.21331528947841089,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,-0.00524,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,92.31,-,-0.3679,0.2115,-22.1457,-4.75499563869662,0.6493564333611429,Uncertain,0.7177,pathogenic,-3.676,available,https://doi.org/10.1101/2022.10.22.513328 +T118R,NP_000537:p.Thr118Arg,"hg19,17:g.7579334G>C, hg38,17:g.7676016G>C",,,0.907,"COSMIC,ClinVar,saturation_mutlist",3460317,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.1632,1.3480949401855469,1.00374,-0.3269251919678495,0.58347,-0.08186259598392476,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.036,,,Uncertain,0.08902,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,92.31,-,-0.3888,0.2115,-22.1457,-4.92809207480131,0.4568090995831356,Uncertain,0.6794,pathogenic,-3.834,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T118S,NP_000537:p.Thr118Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.5593,0.3610517382621765,0.86565,0.483010183793825,0.712475,0.5211550918969126,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.00878,Neutral,,,Uncertain,27.2,,False,27.2,,neutral,,,DOWN,destabilizing,neutral,False,neutral,neutral,92.31,-,-0.1988,0.2115,-8.8578,-2.77593355947402,0.3128861072223863,Benign,0.5334,ambiguous,-3.454,available,https://doi.org/10.1101/2022.10.22.513328 +T118V,NP_000537:p.Thr118Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.25188,0.4938992857933044,0.79252,-0.3971016195508214,0.5222,-0.0726108097754107,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,0.0,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,92.31,-,-0.2485,0.2115,-8.8578,-3.95215341466343,0.0163588081705253,Benign,0.4668,ambiguous,-3.625,available,https://doi.org/10.1101/2022.10.22.513328 +T118W,NP_000537:p.Thr118Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.45252,0.2354381084442138,1.29354,-0.8014561078296417,0.87303,-0.17446805391482087,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,-2e-05,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,92.31,-,-0.403,0.2115,-22.1457,-6.58689514793135,0.8630418219491252,Pathogenic,0.9448,pathogenic,-4.376,available,https://doi.org/10.1101/2022.10.22.513328 +T118Y,NP_000537:p.Thr118Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.41715,0.4724972248077392,1.27789,-0.4173934531177359,0.84752,-0.00012172655886794059,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,Uncertain,-0.02725,Neutral,,,Uncertain,27.2,,False,27.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,92.31,-,-0.3437,0.2115,-8.8578,-4.60516904540867,0.7611125690057705,Pathogenic,0.8869,pathogenic,-3.952,available,https://doi.org/10.1101/2022.10.22.513328 +A119C,NP_000537:p.Ala119Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.5948,-0.0244777798652648,0.83912,0.797275195948395,0.71696,0.6960375979741975,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,-0.49231,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.3278,0.1344,-22.155,-4.27668812018761,0.8624141326905748,Pathogenic,0.9391,pathogenic,-4.265,available,https://doi.org/10.1101/2022.10.22.513328 +A119D,NP_000537:p.Ala119Asp,"hg19,17:g.7579331G>T, hg38,17:g.7676013G>T",,,0.944,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1732774,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.0194,-0.1169267892837524,-3.06361,-0.2969742759305926,-1.5415050000000001,-0.15818713796529632,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,0.03036,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.3417,0.1344,-8.8671,-6.3051272670469,0.8566529756205687,Pathogenic,0.9957,pathogenic,-4.059,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A119E,NP_000537:p.Ala119Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.07565,-0.0698373317718505,-0.34694,-0.4151720867247566,-0.211295,-0.2454110433623783,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,0.02455,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.3952,0.1344,-22.155,-6.3051272670469,0.8371809438782941,Pathogenic,0.9839,pathogenic,-4.072,available,https://doi.org/10.1101/2022.10.22.513328 +A119F,NP_000537:p.Ala119Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.34935,0.3984817266464233,0.41633,-0.2981469061492198,0.38283999999999996,0.0256015469253901,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,0.01972,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.3779,0.1344,-22.155,-6.38204038631388,0.8412958420806412,Pathogenic,0.9736,pathogenic,-4.292,available,https://doi.org/10.1101/2022.10.22.513328 +A119G,NP_000537:p.Ala119Gly,"hg19,17:g.7579330_7579331delinsAC, hg19,17:g.7579331G>C, hg38,17:g.7676012_7676013delinsAC, hg38,17:g.7676013G>C",,,0.856,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",949408,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.45329,0.1145746111869812,0.68946,0.5427629659702055,0.571375,0.49802648298510277,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,-0.1074,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,92.8,-,-0.3213,0.1344,-22.155,-5.75946166142197,0.5611907604189201,Uncertain,0.8488,pathogenic,-3.687,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A119H,NP_000537:p.Ala119His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.62659,0.2731801271438598,-0.63537,-0.4629465474841049,-0.004390000000000005,0.08182172625794754,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,-0.2518,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.382,0.1344,-22.155,-6.14196185588319,0.8521184244496525,Pathogenic,0.972,pathogenic,-4.14,available,https://doi.org/10.1101/2022.10.22.513328 +A119I,NP_000537:p.Ala119Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.66807,0.4810022115707397,1.02891,-0.225756725972504,0.84849,0.22115663701374802,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,0.27277,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.3674,0.1344,-22.155,-5.93814277022035,0.8708042073713154,Pathogenic,0.9856,pathogenic,-4.238,available,https://doi.org/10.1101/2022.10.22.513328 +A119K,NP_000537:p.Ala119Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.19572,0.3133987188339233,0.20816,-0.2208019655299936,0.20194,-0.012540982764996794,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,0.02502,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.3998,0.1344,-22.155,-5.4665769148994,0.3842096195255201,Uncertain,0.9794,pathogenic,-3.879,available,https://doi.org/10.1101/2022.10.22.513328 +A119L,NP_000537:p.Ala119Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30894,0.3427052497863769,0.1381,-0.3980742972014334,0.22352,-0.0445671486007167,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,0.13854,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.3722,0.1344,-22.155,-5.50880566265892,0.8473608779283173,Pathogenic,0.8575,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328 +A119M,NP_000537:p.Ala119Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.19955,0.2992334365844726,0.58571,-0.1263119322687061,0.39263,0.03661903386564695,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,0.03603,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.3309,0.1344,-22.155,-4.54758151803318,0.858572564882069,Pathogenic,0.9288,pathogenic,-4.276,available,https://doi.org/10.1101/2022.10.22.513328 +A119N,NP_000537:p.Ala119Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.60283,0.1368554830551147,-0.33912,-0.112820462079512,0.131855,0.24500476896024398,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,-0.31216,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.3799,0.1344,-22.155,-5.56175638138794,0.7321627762930376,Pathogenic,0.9586,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328 +A119P,NP_000537:p.Ala119Pro,"hg19,17:g.7579332C>G, hg38,17:g.7676014C>G",,,0.899,"ClinVar,saturation_mutlist",481073,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.41368,0.521685779094696,2.49116,0.9904379291239308,1.03874,0.28837896456196543,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,-0.01562,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.4492,0.1344,-22.155,-4.29837734991741,0.5695207436938106,Uncertain,0.9356,pathogenic,-3.698,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A119Q,NP_000537:p.Ala119Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.37579,0.2042949795722961,0.16497,0.0371368486220136,0.27038,0.2064634243110068,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,0.06696,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.3774,0.1344,-22.155,-6.12452429897059,0.6975397973374314,Pathogenic,0.9055,pathogenic,-3.914,available,https://doi.org/10.1101/2022.10.22.513328 +A119R,NP_000537:p.Ala119Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.08254,0.3977649211883545,0.65068,-0.3117298442739541,0.36661,-0.11459492213697706,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,-0.51132,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.4105,0.1344,-22.155,-6.08010840545269,0.8256439209195587,Pathogenic,0.91,pathogenic,-4.077,available,https://doi.org/10.1101/2022.10.22.513328 +A119S,NP_000537:p.Ala119Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.2411,0.0600913763046264,-0.49422,-0.0846136049227508,-0.12656,0.0782431975386246,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,-0.38715,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,92.8,-,-0.2925,0.1344,-22.155,-3.24051340143622,0.1202174396939922,Benign,0.4178,ambiguous,-3.516,available,https://doi.org/10.1101/2022.10.22.513328 +A119T,NP_000537:p.Ala119Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.87211,0.2316270470619201,0.03401,-0.0281749173930689,0.45306,0.4219675413034656,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,-0.13954,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.2163,0.1344,-6.0599,-1.94280040245004,0.006936515177311,Benign,0.6385,pathogenic,-3.308,available,https://doi.org/10.1101/2022.10.22.513328 +A119V,NP_000537:p.Ala119Val,"hg38,17:g.7676013G>A",,,0.906,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.96462,0.5100128650665283,0.52585,-0.125466658031505,0.7452350000000001,0.4195766709842475,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,0.21583,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.2955,0.1344,-22.155,-5.19463022480001,0.7875647560767945,Pathogenic,0.9157,pathogenic,-3.832,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A119W,NP_000537:p.Ala119Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.31565,0.3128334879875183,0.7881,-0.6483224426266637,0.551875,-0.16633622131333187,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,0.03682,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.3888,0.1344,-22.155,-6.38204038631388,0.8703198761976335,Pathogenic,0.9949,pathogenic,-4.49,available,https://doi.org/10.1101/2022.10.22.513328 +A119Y,NP_000537:p.Ala119Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35116,0.4111077785491943,0.2551,-0.237378442940922,0.30313,0.05689077852953901,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.04,,,Uncertain,-0.00461,Neutral,,,Uncertain,77.5,,False,77.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,92.8,-,-0.3971,0.1344,-22.155,-5.83273671044891,0.857859601798747,Pathogenic,0.9863,pathogenic,-4.202,available,https://doi.org/10.1101/2022.10.22.513328 +K120A,NP_000537:p.Lys120Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.02637,-0.316446840763092,-0.1085,0.0212681669715497,-0.041065,0.02381908348577485,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.32746,,Uncertain,1.4653,Destabilizing,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,87.74,T,-0.318,0.0442,-22.155,-5.42345654134594,0.7836222577138889,Pathogenic,0.9942,pathogenic,-4.103,available,https://doi.org/10.1101/2022.10.22.513328 +K120C,NP_000537:p.Lys120Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.33124,-0.2484447360038757,0.61156,0.8611938402113991,0.4714,0.5962169201056995,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.3363,,Uncertain,0.96021,Neutral,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,damaging,87.74,T,-0.3882,0.0442,-22.155,-6.04496054322028,0.8657877618328808,Pathogenic,0.9994,pathogenic,-4.483,available,https://doi.org/10.1101/2022.10.22.513328 +K120D,NP_000537:p.Lys120Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.13287,-0.2111233472824096,-0.01088,-0.1712633210727931,-0.071875,-0.15206666053639656,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.33074,,Uncertain,1.95015,Destabilizing,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,87.74,T,-0.427,0.0442,-22.155,-5.60095398876375,0.8614923113132844,Pathogenic,0.9983,pathogenic,-4.444,available,https://doi.org/10.1101/2022.10.22.513328 +K120E,NP_000537:p.Lys120Glu,"hg19,17:g.7579329T>C, hg19,17:g.7676011T>C, hg38,17:g.7676011T>C",,,0.925,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141098,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.23829,-0.3776901364326477,-0.21837,-0.2876461820727233,-0.22833,-0.26296809103636165,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.43256,0.24643,Neutral,1.55655,Destabilizing,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,87.74,T,-0.3429,0.0442,-22.155,-4.63546258999546,0.8675905169079631,Pathogenic,0.9978,pathogenic,-4.396,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K120F,NP_000537:p.Lys120Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2878,0.3823741972446441,0.21769,-0.1483906433791992,-0.035055,-0.2180953216895996,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.22968,,Uncertain,0.22048,Neutral,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,87.74,T,-0.3891,0.0442,-22.155,-6.40246030540746,0.8539927060900383,Pathogenic,0.9997,pathogenic,-4.524,available,https://doi.org/10.1101/2022.10.22.513328 +K120G,NP_000537:p.Lys120Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30682,0.2528151273727417,0.83265,0.5214017924259142,0.569735,0.4141108962129571,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.33402,,Uncertain,1.78686,Destabilizing,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,87.74,T,-0.3772,0.0442,-22.155,-7.28062631544254,0.8698622570857691,Pathogenic,0.9951,pathogenic,-4.346,available,https://doi.org/10.1101/2022.10.22.513328 +K120H,NP_000537:p.Lys120His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28351,-0.1534635424613952,0.18435,-0.2703834052356674,0.23393,0.006563297382166294,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.26072,,Uncertain,1.54314,Destabilizing,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,87.74,T,-0.3281,0.0442,-22.155,-6.40246030540746,0.868361784799802,Pathogenic,0.9946,pathogenic,-4.224,available,https://doi.org/10.1101/2022.10.22.513328 +K120I,NP_000537:p.Lys120Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.09587,0.1541115045547485,0.18844,-0.1842824759818684,0.142155,-0.0442062379909342,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.40732,,Uncertain,0.96183,Neutral,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,87.74,T,-0.3563,0.0442,-22.155,-7.28062631544254,0.8704956913637367,Pathogenic,0.9992,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328 +K120L,NP_000537:p.Lys120Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.14782,0.1175666451454162,0.23912,-0.522029036203947,0.045649999999999996,-0.33492451810197355,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.2548,,Uncertain,0.69935,Neutral,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,87.74,T,-0.355,0.0442,-22.155,-7.28062631544254,0.8706004015923767,Pathogenic,0.9973,pathogenic,-4.483,available,https://doi.org/10.1101/2022.10.22.513328 +K120M,NP_000537:p.Lys120Met,"hg19,17:g.7579328T>A, hg38,17:g.7676010T>A",,,0.920,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",917693,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.33347,0.2183268368244171,0.33707,-0.152363306520471,0.001799999999999996,-0.24291665326023548,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.20214,0.1096,Neutral,0.77319,Neutral,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,87.74,T,-0.2603,0.0442,-8.8671,-7.28062631544254,0.8707780335020721,Pathogenic,0.997,pathogenic,-4.416,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K120N,NP_000537:p.Lys120Asn,"hg19,17:g.7579327C>A, hg19,17:g.7579327C>G, hg19,17:g.7676009C>A, hg38,17:g.7676009C>A",,,0.862,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22014,-0.075189471244812,0.14456,0.0862938683326886,0.18235,0.1532169341663443,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.29604,0.08948,Neutral,1.66697,Destabilizing,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,87.74,T,-0.3362,0.0442,-22.155,-5.54074595282046,0.7438368825816526,Pathogenic,0.9987,pathogenic,-4.059,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K120P,NP_000537:p.Lys120Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.85436,-0.2069689631462097,-1.01429,0.4010495318837176,-0.934325,-0.2266552340581412,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.30562,,Uncertain,2.22347,Destabilizing,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,87.74,T,-0.4923,0.0442,-22.155,-7.28062631544254,0.8703396077688951,Pathogenic,0.9866,pathogenic,-4.361,available,https://doi.org/10.1101/2022.10.22.513328 +K120Q,NP_000537:p.Lys120Gln,"hg19,17:g.7579329T>G, hg19,17:g.7676011T>G, hg38,17:g.7676011T>G",,,0.899,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",423255,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01959,-0.144464910030365,0.0915,-0.0067948376777532,0.055545,0.0063975811611234005,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.22796,-0.11086,Neutral,1.3183,Destabilizing,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,87.74,T,-0.3172,0.0442,-22.155,-4.56771286265142,0.7966803097578257,Pathogenic,0.9942,pathogenic,-3.993,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K120R,NP_000537:p.Lys120Arg,"hg19,17:g.7579328T>C, hg38,17:g.7676009_7676010delinsTC, hg38,17:g.7676010T>C",,,0.861,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1360099,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.21832,0.1457915902137756,0.48605,-0.0754360426242722,0.35218499999999997,0.0714419786878639,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,-0.23486,0.00594,Neutral,0.77081,Neutral,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,87.74,T,-0.2516,0.0442,-22.155,-3.63933736432837,0.6458355451233061,Uncertain,0.6345,pathogenic,-3.649,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K120S,NP_000537:p.Lys120Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.2685,-0.3112555146217346,-0.13197,0.0963280688300294,0.068265,0.1824140344150147,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.34108,,Uncertain,0.85366,Neutral,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,87.74,T,-0.3282,0.0442,-22.155,-4.38727971150328,0.6559657944313169,Uncertain,0.9962,pathogenic,-4.037,available,https://doi.org/10.1101/2022.10.22.513328 +K120T,NP_000537:p.Lys120Thr,"hg19,17:g.7579328T>G, hg38,17:g.7676010T>G",,,0.917,"COSMIC,ClinVar,saturation_mutlist",3780731,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30705,0.1410520672798156,0.27415,0.0573635341264938,0.29059999999999997,0.1822067670632469,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.33382,0.25046,Neutral,0.34021,Neutral,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,87.74,T,-0.34,0.0442,-22.155,-5.90090569288512,0.8212977215190145,Pathogenic,0.9939,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K120V,NP_000537:p.Lys120Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.39764,0.1378664970397949,0.18537,-0.0117660963262833,0.291505,0.19293695183685836,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.31466,,Uncertain,0.96732,Neutral,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,87.74,T,-0.2724,0.0442,-8.8671,-7.28062631544254,0.8615982983534328,Pathogenic,0.9979,pathogenic,-4.483,available,https://doi.org/10.1101/2022.10.22.513328 +K120W,NP_000537:p.Lys120Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.35699,0.248070478439331,0.12721,-0.6695556554294096,-0.11488999999999999,-0.5132728277147048,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,-0.10192,,Uncertain,0.49958,Neutral,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,87.74,T,-0.3981,0.0442,-22.155,-6.40246030540746,0.8707554770938442,Pathogenic,0.9993,pathogenic,-4.654,available,https://doi.org/10.1101/2022.10.22.513328 +K120Y,NP_000537:p.Lys120Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2342,0.1902375221252441,0.04184,-0.0913104323345298,-0.09617999999999999,-0.1627552161672649,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,-0.21602,,Uncertain,-0.26135,Neutral,,,Uncertain,96.2,,False,96.2,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,87.74,T,-0.374,0.0442,-22.155,-6.03995345266635,0.8506298220477309,Pathogenic,0.9987,pathogenic,-4.417,available,https://doi.org/10.1101/2022.10.22.513328 +S121A,NP_000537:p.Ser121Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.05322,0.2551307678222656,0.27585,0.2690269331533729,0.164535,0.16112346657668644,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.0,,Uncertain,0.02799,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,91.82,T,-0.278,0.0222,-22.155,-2.88339815913178,0.5701486809014564,Uncertain,0.7746,pathogenic,-3.605,available,https://doi.org/10.1101/2022.10.22.513328 +S121C,NP_000537:p.Ser121Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.16504,-0.1880159974098205,0.75816,0.8951447600293644,0.29656,0.3650523800146822,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.0,,Uncertain,0.01829,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3285,0.0222,-22.155,-3.61256238654893,0.765557032265726,Pathogenic,0.9438,pathogenic,-4.078,available,https://doi.org/10.1101/2022.10.22.513328 +S121D,NP_000537:p.Ser121Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.03519,-0.2648584246635437,-0.94014,-0.1872837570504271,-0.487665,-0.11123687852521355,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.10106,,Uncertain,0.48555,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3767,0.0222,-22.155,-5.79217437486609,0.8633620873491314,Pathogenic,0.9965,pathogenic,-4.19,available,https://doi.org/10.1101/2022.10.22.513328 +S121E,NP_000537:p.Ser121Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.41152,0.0999014973640441,-0.19184,-0.1702869174812643,-0.30168,-0.29090345874063217,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.07104,,Uncertain,0.04219,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3499,0.0222,-22.155,-5.79217437486609,0.8703269038904776,Pathogenic,0.9959,pathogenic,-4.25,available,https://doi.org/10.1101/2022.10.22.513328 +S121F,NP_000537:p.Ser121Phe,"hg19,17:g.7579325G>A, hg38,17:g.7676007G>A",,,0.928,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.36671,0.3304794430732727,0.0949,-0.4044462188507763,-0.135905,-0.38557810942538817,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.22894,-0.00256,Neutral,-1.11418,Stabilizing,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3561,0.0222,-22.155,-3.87121486998236,0.8643497312344928,Pathogenic,0.9907,pathogenic,-4.37,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S121G,NP_000537:p.Ser121Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.11629,-0.3257061839103699,0.76054,0.770374777361223,0.438415,0.4433323886806115,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.0,,Uncertain,0.04012,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,91.82,T,-0.2194,0.0222,-8.8671,-5.57161837826126,0.640821789555123,Uncertain,0.907,pathogenic,-3.722,available,https://doi.org/10.1101/2022.10.22.513328 +S121H,NP_000537:p.Ser121His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.21477,0.2376273274421692,0.07517,-0.3731692333040853,0.14497,-0.07919961665204266,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,6e-05,,Uncertain,0.122,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3573,0.0222,-22.155,-4.7861890334447,0.8331799204256038,Pathogenic,0.9875,pathogenic,-4.156,available,https://doi.org/10.1101/2022.10.22.513328 +S121I,NP_000537:p.Ser121Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.17314,0.9214255213737488,0.39728,0.0439636872984727,0.11207000000000002,-0.06458815635076365,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.00066,,Uncertain,0.00178,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3592,0.0222,-22.155,-7.22257451018822,0.7974786034438025,Pathogenic,0.9901,pathogenic,-4.375,available,https://doi.org/10.1101/2022.10.22.513328 +S121K,NP_000537:p.Ser121Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.37746,0.5157886743545532,0.07245,-0.0121416958995468,-0.152505,-0.1948008479497734,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.00522,,Uncertain,-0.10307,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3666,0.0222,-22.155,-5.17881081672149,0.8107863267030521,Pathogenic,0.9986,pathogenic,-3.956,available,https://doi.org/10.1101/2022.10.22.513328 +S121L,NP_000537:p.Ser121Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.1358,0.6613831520080566,0.02415,-0.2314617970325777,-0.055825,-0.18363089851628883,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.00434,,Uncertain,-0.20556,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3555,0.0222,-22.155,-7.22257451018822,0.8654774530507405,Pathogenic,0.9858,pathogenic,-4.336,available,https://doi.org/10.1101/2022.10.22.513328 +S121M,NP_000537:p.Ser121Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.4179,0.5059656500816345,0.54864,0.1040092208440524,0.06537000000000001,-0.1569453895779738,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.00014,,Uncertain,-0.92193,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3265,0.0222,-22.155,-7.22257451018822,0.8582265101531388,Pathogenic,0.9709,pathogenic,-4.35,available,https://doi.org/10.1101/2022.10.22.513328 +S121N,NP_000537:p.Ser121Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.02755,-0.0754427313804626,-0.10442,-0.0094671824264502,-0.038435,0.009041408786774901,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.0018,,Uncertain,0.42493,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3003,0.0222,-22.155,-4.48590039048582,0.6730832011556374,Uncertain,0.9749,pathogenic,-3.705,available,https://doi.org/10.1101/2022.10.22.513328 +S121P,NP_000537:p.Ser121Pro,"hg19,17:g.7579326A>G, hg38,17:g.7676008A>G",,,0.944,"ClinVar,saturation_mutlist",854451,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01388,1.05367112159729,4.07789,1.250472521435389,2.045885,0.6321762607176944,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.07,-0.00952,-0.03416,Neutral,0.0004,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.4315,0.0222,-22.155,-7.22257451018822,0.8646101591036084,Pathogenic,0.9975,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S121Q,NP_000537:p.Ser121Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.22614,0.356149673461914,0.21361,0.2065712115765378,-0.006265000000000007,-0.009784394211731107,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.0,,Uncertain,-0.426,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3199,0.0222,-22.155,-4.42658788278325,0.7369001124810637,Pathogenic,0.9903,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328 +S121R,NP_000537:p.Ser121Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.21177,0.5450364351272583,0.51599,-0.0559626900091686,0.15210999999999997,-0.1338663450045843,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.01052,,Uncertain,-0.78708,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3719,0.0222,-22.155,-4.90349223605351,0.6071277607450033,Uncertain,0.9978,pathogenic,-3.955,available,https://doi.org/10.1101/2022.10.22.513328 +S121T,NP_000537:p.Ser121Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.41827,0.2453588843345642,0.15442,0.2338651994580332,0.28634499999999996,0.32606759972901656,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.0006,0.0013,Neutral,0.29711,Neutral,,,Uncertain,100.4,,False,100.4,,neutral,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.2687,0.0222,-22.155,-2.93737178047625,0.6696040077831568,Uncertain,0.8597,pathogenic,-3.744,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S121V,NP_000537:p.Ser121Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.24701,0.8324316143989563,0.30306,0.1422833825020802,0.27503500000000003,0.19464669125104012,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.0008,,Uncertain,0.24039,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3335,0.0222,-22.155,-7.22257451018822,0.8668198396912001,Pathogenic,0.9869,pathogenic,-4.25,available,https://doi.org/10.1101/2022.10.22.513328 +S121W,NP_000537:p.Ser121Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.3319,0.0571653842926025,-0.47245,-0.8259447420617066,-0.40217499999999995,-0.5789223710308533,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.0,,Uncertain,-0.71421,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3658,0.0222,-22.155,-6.20863209751825,0.8624378634923795,Pathogenic,0.9743,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328 +S121Y,NP_000537:p.Ser121Tyr,"hg19,17:g.7579325G>T, hg19,17:g.7676007G>T, hg38,17:g.7676007G>T",,,0.921,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",4427947,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.31345,0.2647403478622436,-0.14524,-0.3448609089831528,-0.22934500000000002,-0.3291554544915764,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.05182,0.00812,Neutral,-0.02693,Neutral,,,Uncertain,100.4,,False,100.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,91.82,T,-0.3609,0.0222,-22.155,-5.93163641213085,0.867154259992369,Pathogenic,0.977,pathogenic,-4.387,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V122A,NP_000537:p.Val122Ala,"hg19,17:g.7579322A>G, hg38,17:g.7676004A>G",,,0.650,"ClinVar,saturation_mutlist",1465964,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.81787,0.1708812713623047,1.70748,2.1207027588953085,1.262675,1.4692863794476543,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.148,0.0,-0.0841,Neutral,-0.00528,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.69,-,-0.1509,0.9804,-0.7004,-1.76350618499936,0.0027183795131928,Benign,0.7958,pathogenic,-3.23,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V122C,NP_000537:p.Val122Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.67077,-0.2277131080627441,1.67687,2.341857952479691,1.17382,1.5063139762398456,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.148,0.01152,,,-0.00011,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.69,-,-0.2882,0.9804,-22.1581,-3.66496848799178,0.85979189287393,Pathogenic,0.9758,pathogenic,-4.11,available,https://doi.org/10.1101/2022.10.22.513328 +V122D,NP_000537:p.Val122Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.84589,0.5388882160186768,1.25476,2.829633198060372,1.550325,2.337761599030186,Neutral,Uncertain,Neutral,Neutral,Uncertain,False,0.148,0.1824,,,-0.0935,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.69,-,-0.427,0.9804,-22.1581,-4.97407101704693,0.8539304849706768,Pathogenic,0.9947,pathogenic,-4.408,available,https://doi.org/10.1101/2022.10.22.513328 +V122E,NP_000537:p.Val122Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.06433,-0.2159174680709839,1.59898,2.8051471159767387,1.331655,1.9347385579883694,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.148,0.12724,,,-0.0458,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.69,-,-0.3843,0.9804,-22.1581,-4.97407101704693,0.8669532001292661,Pathogenic,0.9809,pathogenic,-4.332,available,https://doi.org/10.1101/2022.10.22.513328 +V122F,NP_000537:p.Val122Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48672,0.2673031687736511,0.92721,1.6140073306898508,0.706965,1.0503636653449253,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.148,0.0,,,-0.01261,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.69,-,-0.3375,0.9804,-22.1581,-5.92997476481835,0.8671019742300847,Pathogenic,0.9381,pathogenic,-4.095,available,https://doi.org/10.1101/2022.10.22.513328 +V122G,NP_000537:p.Val122Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.8862,1.0831167697906494,3.53673,3.49346480098294,2.711465,2.68983240049147,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.148,0.0,,,-0.01261,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.69,-,-0.3862,0.9804,-22.1581,-6.29330782092666,0.787640046476105,Pathogenic,0.9441,pathogenic,-4.074,available,https://doi.org/10.1101/2022.10.22.513328 +V122H,NP_000537:p.Val122His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.7493,0.3623567223548889,2.18878,2.068767664507623,1.9690400000000001,1.9090338322538116,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.148,0.0,,,-0.01261,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.69,-,-0.4299,0.9804,-22.1581,-5.92997476481835,0.7085672877222389,Pathogenic,0.9936,pathogenic,-4.276,available,https://doi.org/10.1101/2022.10.22.513328 +V122I,NP_000537:p.Val122Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.06788,0.2104191780090332,0.37517,0.6830311313957612,0.721525,0.8754555656978806,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.148,0.0,,,0.0,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.69,-,-0.1959,0.9804,-22.1581,-3.67399170888624,0.1270954160997734,Benign,0.4737,ambiguous,-3.674,available,https://doi.org/10.1101/2022.10.22.513328 +V122K,NP_000537:p.Val122Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.78059,0.6950967311859131,2.55646,2.6444017715562005,1.668525,1.7124958857781003,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.148,-0.00682,,,0.00405,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.69,-,-0.4232,0.9804,-22.1581,-4.97321975239921,0.7115895917646837,Pathogenic,0.9834,pathogenic,-4.03,available,https://doi.org/10.1101/2022.10.22.513328 +V122L,NP_000537:p.Val122Leu,"hg19,17:g.7579323C>A, hg38,17:g.7676005C>A",,,0.730,"COSMIC,ClinVar,saturation_mutlist",2121740,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.60406,-0.0312635898590087,1.69456,1.0592403071887238,1.14931,0.8316501535943619,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.148,0.0,0.1039,Neutral,-0.01261,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.69,-,-0.1932,0.9804,-8.8702,-2.71835073884853,0.5879473918055794,Uncertain,0.9597,pathogenic,-3.609,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V122M,NP_000537:p.Val122Met,"hg19,17:g.7579323C>T, hg38,17:g.7676005C>T",,,0.770,"cBioPortal,ClinVar,saturation_mutlist",141101,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.60536,-0.2250751256942749,1.67245,1.5587122537457216,1.138905,1.0820361268728609,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.148,0.0,0.0133,Neutral,-0.01272,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.69,-,-0.2701,0.9804,-22.1581,-3.60531022220006,0.5534714396146241,Uncertain,0.8281,pathogenic,-3.819,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V122N,NP_000537:p.Val122Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.81026,0.6842182874679565,2.62925,2.0298688488189955,2.219755,1.9200644244094978,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.148,0.0,,,-0.01145,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.69,-,-0.4148,0.9804,-22.1581,-3.63982935137633,0.1930178990821741,Benign,0.974,pathogenic,-3.949,available,https://doi.org/10.1101/2022.10.22.513328 +V122P,NP_000537:p.Val122Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.63369,1.907743215560913,8.21871,3.2350653981793425,5.9262,3.434377699089671,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.148,0.00072,,,0.1131,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.69,-,-0.4647,0.9804,-22.1581,-4.59805773752566,0.3002226023770185,Benign,0.9936,pathogenic,-3.954,available,https://doi.org/10.1101/2022.10.22.513328 +V122Q,NP_000537:p.Val122Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.43471,0.0214644074440002,1.49898,2.2667720225334977,1.466845,1.8507410112667488,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.148,0.0,,,-0.01261,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.69,-,-0.3949,0.9804,-22.1581,-3.67916714786858,0.7490731174394698,Pathogenic,0.9496,pathogenic,-4.015,available,https://doi.org/10.1101/2022.10.22.513328 +V122R,NP_000537:p.Val122Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.33086,0.706974983215332,2.77959,2.051269768087205,2.055225,1.6910648840436024,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.148,-0.01046,,,0.00532,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.69,-,-0.4442,0.9804,-22.1581,-5.1855809362478,0.624260275438607,Uncertain,0.9576,pathogenic,-4.179,available,https://doi.org/10.1101/2022.10.22.513328 +V122S,NP_000537:p.Val122Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.30008,0.3632884621620178,2.6534,2.5059534840365454,1.97674,1.9030167420182726,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.148,0.0,,,0.00031,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.69,-,-0.364,0.9804,-22.1581,-2.95170511528338,0.5044674811243428,Uncertain,0.867,pathogenic,-3.766,available,https://doi.org/10.1101/2022.10.22.513328 +V122T,NP_000537:p.Val122Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.15223,0.1371349096298217,1.42755,1.6971644669025732,1.2898900000000002,1.4246972334512866,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.148,0.0,,,-0.00734,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.69,-,-0.2794,0.9804,-22.1581,-2.3155515721326,0.1545036367206991,Benign,0.8814,pathogenic,-3.634,available,https://doi.org/10.1101/2022.10.22.513328 +V122W,NP_000537:p.Val122Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.27266,0.1683986186981201,1.30272,1.7482121449195576,1.28769,1.5104360724597787,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.148,0.0,,,-0.01261,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.69,-,-0.3781,0.9804,-22.1581,-5.92997476481835,0.8672802549628518,Pathogenic,0.9988,pathogenic,-4.506,available,https://doi.org/10.1101/2022.10.22.513328 +V122Y,NP_000537:p.Val122Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.79792,0.2562800049781799,0.96939,1.836837531686368,0.883655,1.3173787658431841,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.148,0.0,,,0.04977,Neutral,,,,24.1,,False,24.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.69,-,-0.381,0.9804,-22.1581,-4.62999008249986,0.8695452723611845,Pathogenic,0.9925,pathogenic,-4.191,available,https://doi.org/10.1101/2022.10.22.513328 +T123A,NP_000537:p.Thr123Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.50209,0.7075416445732117,0.05748,0.5056806268786379,-0.22230500000000003,0.0017953134393189352,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,0.00128,,Uncertain,0.0,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.2998,0.2461,-22.1612,-1.41306825243521,0.3841325060514203,Uncertain,0.4842,ambiguous,-3.608,available,https://doi.org/10.1101/2022.10.22.513328 +T123C,NP_000537:p.Thr123Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.27549,0.3810944557189941,0.70204,0.8664363930382252,0.213275,0.2954731965191126,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,-0.0005,,Uncertain,0.00793,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.3356,0.2461,-22.1612,-4.21812374764703,0.8640373324656396,Pathogenic,0.8758,pathogenic,-4.162,available,https://doi.org/10.1101/2022.10.22.513328 +T123D,NP_000537:p.Thr123Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.22268,0.8842817544937134,0.42075,0.7604613574296071,0.09903500000000001,0.26889067871480354,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,0.10682,,Uncertain,0.00217,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,96.78,S,-0.4153,0.2461,-22.1612,-4.22874243016215,0.5229433035074851,Uncertain,0.9735,pathogenic,-3.944,available,https://doi.org/10.1101/2022.10.22.513328 +T123E,NP_000537:p.Thr123Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.36977,0.459663450717926,-0.23027,0.4446799062073608,-0.80002,-0.4625450468963196,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,0.08066,,Uncertain,-0.00353,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.3907,0.2461,-22.1612,-5.28283851591469,0.776163550631777,Pathogenic,0.96,pathogenic,-4.128,available,https://doi.org/10.1101/2022.10.22.513328 +T123F,NP_000537:p.Thr123Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.197,0.8117827773094177,-0.0966,-0.6172024536951964,-0.6468,-0.9071012268475982,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,-0.00036,,Uncertain,-0.00243,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.407,0.2461,-22.1612,-4.29300010611783,0.783502131792862,Pathogenic,0.8463,pathogenic,-4.222,available,https://doi.org/10.1101/2022.10.22.513328 +T123G,NP_000537:p.Thr123Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.04796,0.8544507026672363,1.14286,1.3032957856796192,0.59541,0.6756278928398096,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,0.00534,,Uncertain,0.0,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.3732,0.2461,-22.1612,-5.98280747713691,0.6319014439985808,Uncertain,0.7888,pathogenic,-3.979,available,https://doi.org/10.1101/2022.10.22.513328 +T123H,NP_000537:p.Thr123His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01139,0.7660840749740601,0.13537,-0.1531512890565106,0.061989999999999996,-0.0822706445282553,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,-0.00046,,Uncertain,-0.00526,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.3873,0.2461,-22.1612,-4.86123686648965,0.4012280187108658,Uncertain,0.8737,pathogenic,-3.864,available,https://doi.org/10.1101/2022.10.22.513328 +T123I,NP_000537:p.Thr123Ile,"hg19,17:g.7579319G>A, hg38,17:g.7676001G>A",,,0.859,"COSMIC,ClinVar,saturation_mutlist",480737,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.06783,0.5194500088691711,0.05986,-0.172794777112612,-0.503985,-0.620312388556306,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,0.00684,0.00137,Neutral,0.00394,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.2498,0.2461,-7.2884,-3.81089778015391,0.5781656728163203,Uncertain,0.7275,pathogenic,-3.844,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T123K,NP_000537:p.Thr123Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.29472,0.7154694199562073,0.45442,0.3438586759752182,-0.42015,-0.4754306620123909,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,-0.01354,,Uncertain,0.00399,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.3829,0.2461,-22.1612,-5.66172147520125,0.6914001769176373,Pathogenic,0.9036,pathogenic,-3.811,available,https://doi.org/10.1101/2022.10.22.513328 +T123L,NP_000537:p.Thr123Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.3287,0.5205687284469604,0.29558,-0.5043029325597626,-0.51656,-0.9165014662798813,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,0.01736,,Uncertain,-4e-05,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.3098,0.2461,-8.8733,-4.37161777354302,0.760879372013092,Pathogenic,0.3986,ambiguous,-4.012,available,https://doi.org/10.1101/2022.10.22.513328 +T123M,NP_000537:p.Thr123Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.54645,0.5784147381782532,0.7034,-0.1166868595855574,-0.42152500000000004,-0.8315684297927788,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,0.00664,,Uncertain,-0.00146,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.2614,0.2461,-5.8734,-2.12802621584502,0.2717357429090354,Benign,0.2237,benign,-3.614,available,https://doi.org/10.1101/2022.10.22.513328 +T123N,NP_000537:p.Thr123Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.35557,0.8200053572654724,0.33503,0.3944796566930342,-0.010270000000000001,0.0194548283465171,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,0.0001,,Uncertain,0.0,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,96.78,S,-0.3554,0.2461,-22.1612,-4.24343325547966,0.1095035712778922,Benign,0.6684,pathogenic,-3.69,available,https://doi.org/10.1101/2022.10.22.513328 +T123P,NP_000537:p.Thr123Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.09873,0.9198266267776488,-0.36531,1.650863700209955,-0.73202,0.27606685010497756,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,0.02164,,Uncertain,0.0,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,96.78,S,-0.4641,0.2461,-22.1612,-4.40214612507321,0.0409553553751071,Benign,0.5174,ambiguous,-3.789,available,https://doi.org/10.1101/2022.10.22.513328 +T123Q,NP_000537:p.Thr123Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.86523,0.4829646944999695,0.00782,0.2912977008698048,-0.428705,-0.28696614956509764,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,0.006,,Uncertain,0.00402,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.3648,0.2461,-22.1612,-4.11064328734141,0.3018638569533626,Benign,0.7822,pathogenic,-3.767,available,https://doi.org/10.1101/2022.10.22.513328 +T123R,NP_000537:p.Thr123Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.83353,0.8599702715873718,0.42925,-0.0925721804441359,-0.20214,-0.4630510902220679,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,-0.01414,,Uncertain,0.01602,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.3179,0.2461,-8.8733,-4.71948159874475,0.8401218435465783,Pathogenic,0.8629,pathogenic,-4.111,available,https://doi.org/10.1101/2022.10.22.513328 +T123S,NP_000537:p.Thr123Ser,"hg19,17:g.7579319G>C, hg38,17:g.7676001G>C",,,0.729,"ClinVar,saturation_mutlist",1460570,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.66527,0.4385724067687988,0.22109,0.5544444816920813,-0.22209,-0.05541275915395938,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,0.01278,0.0005,Neutral,0.0,Neutral,,,Uncertain,53.5,,False,53.5,,neutral,,,DOWN,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.2635,0.2461,-22.1612,-2.83100541577873,0.0431761108684732,Benign,0.5218,ambiguous,-3.47,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T123V,NP_000537:p.Thr123Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.47501,0.5020889639854431,-0.17993,-0.0204075452024043,-0.32747,-0.24770877260120214,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,0.0003,,Uncertain,0.0,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.2454,0.2461,-8.8733,-4.78053029742989,0.4171463292270749,Uncertain,0.5358,ambiguous,-3.721,available,https://doi.org/10.1101/2022.10.22.513328 +T123W,NP_000537:p.Thr123Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.21056,0.8681749105453491,-0.6915,-1.016729961713189,-0.45103,-0.6136449808565946,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,-0.0004,,Uncertain,0.0,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.3999,0.2461,-22.1612,-5.66312143111933,0.8643231461347172,Pathogenic,0.9634,pathogenic,-4.44,available,https://doi.org/10.1101/2022.10.22.513328 +T123Y,NP_000537:p.Thr123Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.10595,0.8350417613983154,-0.31429,-0.4041130661601178,-0.71012,-0.7550315330800589,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,-0.00038,,Uncertain,0.01067,Neutral,,,Uncertain,53.5,,False,53.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.78,S,-0.4085,0.2461,-22.1612,-4.31933104992387,0.856271009791606,Pathogenic,0.9199,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328 +C124A,NP_000537:p.Cys124Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.70298,0.4819851517677307,0.55612,0.4276788256651787,0.62955,0.5653294128325894,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,damaging,neutral,97.3,E,-0.289,1.4701,-8.8733,-2.18183009910751,0.8160872185967706,Pathogenic,0.718,pathogenic,-3.762,available,https://doi.org/10.1101/2022.10.22.513328 +C124D,NP_000537:p.Cys124Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.56747,1.7998217344284058,1.95442,1.7334656496807028,1.260945,1.1504678248403515,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,-,uncertain,neutral,False,damaging,neutral,97.3,E,-0.4641,1.4701,-22.1612,-5.27984144218348,0.860821369238431,Pathogenic,0.9838,pathogenic,-4.321,available,https://doi.org/10.1101/2022.10.22.513328 +C124E,NP_000537:p.Cys124Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.98409,1.6620221138000488,1.60034,1.0462321371167134,1.2922150000000001,1.0151610685583567,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.4517,1.4701,-22.1612,-5.27984144218348,0.7866239890922151,Pathogenic,0.9944,pathogenic,-4.346,available,https://doi.org/10.1101/2022.10.22.513328 +C124F,NP_000537:p.Cys124Phe,"hg38,17:g.7675998C>A",,,0.792,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.57462,-0.2219196557998657,-1.61939,-2.1024378864735125,-1.097005,-1.3385289432367562,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.283,1.4701,-8.8733,-1.9121478721896,0.0473841459919966,Benign,0.4765,ambiguous,-3.543,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C124G,NP_000537:p.Cys124Gly,"hg19,17:g.7579317A>C, hg19,17:g.7675999A>C, hg38,17:g.7675999A>C",,,0.843,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",230661,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.59467,1.493577480316162,2.35204,2.2057232944622127,1.9733550000000002,1.9001966472311063,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,damaging,neutral,97.3,E,-0.2815,1.4701,-8.8733,-5.88245089714293,0.7125230884979975,Pathogenic,0.5754,pathogenic,-4.017,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C124H,NP_000537:p.Cys124His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.51229,1.3092663288116455,0.4017,-0.5190749311823295,0.45699500000000004,-0.0033924655911647394,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.4626,1.4701,-22.1612,-2.80385490296217,0.6416064908619981,Uncertain,0.915,pathogenic,-4.064,available,https://doi.org/10.1101/2022.10.22.513328 +C124I,NP_000537:p.Cys124Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2867,-0.1707119941711425,1.0449,-1.0942938953713488,0.3791,-0.6904969476856744,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.3807,1.4701,-22.1612,-3.53666427597966,0.7701531978091749,Pathogenic,0.9129,pathogenic,-4.085,available,https://doi.org/10.1101/2022.10.22.513328 +C124K,NP_000537:p.Cys124Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.3297,2.1526808738708496,1.97517,0.4714105009317343,1.152435,0.40055525046586715,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.4523,1.4701,-22.1612,-4.19743582472115,0.784172275961019,Pathogenic,0.9973,pathogenic,-4.214,available,https://doi.org/10.1101/2022.10.22.513328 +C124L,NP_000537:p.Cys124Leu,"hg19,17:g.7579315_7579316delinsTA, hg38,17:g.7675997_7675998delinsTA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.24354,0.8421465158462524,0.12619,-1.17739637344692,-0.058675000000000005,-0.71046818672346,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.4138,1.4701,-22.1612,-3.54227661798402,0.3612036954452436,Uncertain,0.8639,pathogenic,-3.874,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C124M,NP_000537:p.Cys124Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-2.13141,0.5426041483879089,-1.1983,-0.4974643149322771,-1.6648549999999998,-1.3144371574661384,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.381,1.4701,-22.1612,-3.5719436773238,0.7726735272983916,Pathogenic,0.8807,pathogenic,-4.148,available,https://doi.org/10.1101/2022.10.22.513328 +C124N,NP_000537:p.Cys124Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.03909,1.802018165588379,1.10034,0.5683745489525194,1.069715,0.8037322744762597,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.3387,1.4701,-8.8733,-3.98283563887645,0.2525232163193669,Benign,0.8774,pathogenic,-3.758,available,https://doi.org/10.1101/2022.10.22.513328 +C124P,NP_000537:p.Cys124Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.93681,1.9037797451019287,7.51735,4.233502643911862,5.22708,3.585156321955931,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,-,uncertain,neutral,False,damaging,neutral,97.3,E,-0.4752,1.4701,-22.1612,-5.88245089714293,0.7901626306381831,Pathogenic,0.9959,pathogenic,-4.26,available,https://doi.org/10.1101/2022.10.22.513328 +C124Q,NP_000537:p.Cys124Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.89457,1.5485705137252808,0.81054,0.4464971275648316,0.852555,0.6705335637824158,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.4305,1.4701,-22.1612,-4.03048259172124,0.787906315637342,Pathogenic,0.9756,pathogenic,-4.188,available,https://doi.org/10.1101/2022.10.22.513328 +C124R,NP_000537:p.Cys124Arg,"hg19,17:g.7579317A>G, hg19,17:g.7675999A>G, hg38,17:g.7675999A>G",,,0.883,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",4056245,Likely pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.43577,1.948824405670166,1.39626,-0.2874494834012436,0.916015,0.0741602582993782,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.4091,1.4701,-22.1612,-5.29044806310019,0.7677302688161243,Pathogenic,0.9764,pathogenic,-4.037,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C124S,NP_000537:p.Cys124Ser,"hg19,17:g.7579316C>G, hg19,17:g.7579317A>T, hg38,17:g.7675998C>G, hg38,17:g.7675999A>T",3.1843077315e-05,7.9729557341e-06,"0.668, 0.716","COSMIC,ClinVar,ClinVar,saturation_mutlist","1021578, 182926","Uncertain significance, Likely benign","1, 3",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.17678,0.5743958950042725,1.14966,1.164101724874267,0.6632199999999999,0.6704408624371335,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,damaging,neutral,97.3,E,-0.2506,1.4701,-3.1455,-1.74552172632798,7.137384591964712e-05,Benign,0.4372,ambiguous,-3.314,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C124T,NP_000537:p.Cys124Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.10421,0.2716071605682373,-0.04524,0.4603602215607238,-0.5747249999999999,-0.321924889219638,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.3823,1.4701,-22.1612,-3.84241840855199,0.4406528805342293,Uncertain,0.7823,pathogenic,-3.884,available,https://doi.org/10.1101/2022.10.22.513328 +C124V,NP_000537:p.Cys124Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.96357,-0.5514804124832153,-0.40918,-0.7818741559561393,-0.686375,-0.8727220779780697,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.3788,1.4701,-22.1612,-3.48435045668782,0.5519396039363752,Uncertain,0.7651,pathogenic,-3.656,available,https://doi.org/10.1101/2022.10.22.513328 +C124W,NP_000537:p.Cys124Trp,"hg19,17:g.7579315G>C, hg38,17:g.7675997G>C",,,0.537,"ClinVar,saturation_mutlist",3809674,Likely benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.46289,-0.1982944011688232,0.99898,-2.3348750423331963,0.268045,-1.3988825211665983,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.2445,1.4701,-0.7186,-0.067669720157014,0.0038011747740692,Benign,0.7055,pathogenic,-3.194,available,https://doi.org/10.1101/2022.10.22.513328 +C124Y,NP_000537:p.Cys124Tyr,"hg19,17:g.7579316C>T, hg38,17:g.7675998C>T",,,0.713,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.61587,0.0718117952346801,-1.34898,-1.915199125527686,-0.9824250000000001,-1.265534562763843,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.191,,,,,,,,,16.4,,True,16.4,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.3,E,-0.277,1.4701,-5.8734,-1.02496409689317,5.185731656250633e-05,Benign,0.6263,pathogenic,-3.316,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125A,NP_000537:p.Thr125Ala,"hg19,17:g.7579314T>C, hg19,17:g.7675996T>C, hg38,17:g.7675996T>C",,,0.943,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1734453,Uncertain significance,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.84488,0.7881916165351868,1.02551,0.4191165686371773,0.935195,0.6319982843185886,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.82,E,-0.3143,0.088,-22.1612,-3.69569381712477,0.3888783576341865,Uncertain,0.9598,pathogenic,-3.757,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125C,NP_000537:p.Thr125Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.57109,0.4911582469940185,0.75986,0.9956547869849158,0.665475,0.7833723934924579,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.82,E,-0.3501,0.088,-22.1612,-4.44543292242316,0.8446299161327433,Pathogenic,0.9876,pathogenic,-4.015,available,https://doi.org/10.1101/2022.10.22.513328 +T125D,NP_000537:p.Thr125Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.72692,2.568225383758545,3.47075,1.1743418508100714,4.098834999999999,2.9506309254050356,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.82,E,-0.4299,0.088,-22.1612,-5.72277290666319,0.7500211912927643,Pathogenic,0.9926,pathogenic,-4.222,available,https://doi.org/10.1101/2022.10.22.513328 +T125E,NP_000537:p.Thr125Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.7142,2.260488510131836,5.22109,1.0768191245188066,6.467645,4.395509562259403,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.82,E,-0.4052,0.088,-22.1612,-4.27110981250882,0.0790193522187552,Benign,0.9907,pathogenic,-3.946,available,https://doi.org/10.1101/2022.10.22.513328 +T125F,NP_000537:p.Thr125Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,26.0916,1.127791166305542,8.05952,1.0399429587456357,17.07556,13.565771479372817,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.82,E,-0.4215,0.088,-22.1612,-5.99876483395326,0.7456579303036063,Pathogenic,0.99,pathogenic,-3.93,available,https://doi.org/10.1101/2022.10.22.513328 +T125G,NP_000537:p.Thr125Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.13528,1.8678617477416992,2.52381,1.7247013538600466,2.329545,1.9299906769300232,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.82,E,-0.3878,0.088,-22.1612,-5.58781602161766,0.6538406828478669,Uncertain,0.9735,pathogenic,-4.236,available,https://doi.org/10.1101/2022.10.22.513328 +T125H,NP_000537:p.Thr125His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,18.179,1.7751705646514893,6.84762,1.048487317796592,12.513309999999999,9.613743658898295,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.82,E,-0.4018,0.088,-22.1612,-4.8024143711309,0.7653469485409383,Pathogenic,0.9905,pathogenic,-4.098,available,https://doi.org/10.1101/2022.10.22.513328 +T125I,NP_000537:p.Thr125Ile,"hg19,17:g.7579312_7579313delinsGA",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.84468,0.1658613681793213,3.65442,0.0190949019589553,4.24955,2.431887450979478,Destabilizing,Uncertain,Neutral,Destabilizing,Uncertain,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.82,E,-0.3402,0.088,-22.1612,-5.00501852348552,0.2630039935626909,Benign,0.9893,pathogenic,-3.684,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125K,NP_000537:p.Thr125Lys,"hg19,17:g.7579313G>T, hg19,17:g.7675995G>T, hg38,17:g.7675995G>T",,,0.963,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",216465,Pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.21172,1.884384274482727,8.62449,2.006534496629931,10.418105,7.109127248314966,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.82,E,-0.3974,0.088,-22.1612,-2.4608657686824,0.6053490660459484,Uncertain,0.9893,pathogenic,-3.985,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125L,NP_000537:p.Thr125Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.31782,1.0771440267562866,1.43027,0.1705062803978135,2.374045,1.7441631401989068,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.82,E,-0.3921,0.088,-22.1612,-2.58079320149291,0.1985671836638807,Benign,0.9686,pathogenic,-3.811,available,https://doi.org/10.1101/2022.10.22.513328 +T125M,NP_000537:p.Thr125Met,"hg19,17:g.7579313G>A, hg19,17:g.7675995G>A, hg38,17:g.7675995G>A",3.1847133758e-05,,0.925,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",183748,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,4.5817,1.103672981262207,2.92857,0.5261900065206898,3.755135,2.5539450032603446,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.82,E,-0.2913,0.088,-8.8733,-3.69157310336068,0.0017308159673534,Benign,0.9602,pathogenic,-3.54,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125N,NP_000537:p.Thr125Asn,"hg19,17:g.7579312_7579313delinsAT, hg19,17:g.7579312_7579313delinsGT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.24144,2.150876998901367,1.86361,0.9511813529983872,3.052525,2.5963106764991934,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.82,E,-0.3699,0.088,-22.1612,-3.73799870025625,0.7962314885829296,Pathogenic,0.9794,pathogenic,-4.031,available,https://doi.org/10.1101/2022.10.22.513328 +T125P,NP_000537:p.Thr125Pro,"hg19,17:g.7579314T>G, hg19,17:g.7675996T>G, hg38,17:g.7675996T>G",,,0.945,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376666,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.41533,1.7895699739456177,5.42075,5.458640395392269,4.9180399999999995,4.936985197696135,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.82,E,-0.4786,0.088,-22.1612,-5.32216348223569,0.8309450404478289,Pathogenic,0.9855,pathogenic,-4.306,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125Q,NP_000537:p.Thr125Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.09827,1.901745319366455,4.65918,1.0312992918977826,6.378724999999999,4.564784645948891,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.82,E,-0.3116,0.088,-8.8733,-3.03746157648101,0.2547190630195928,Benign,0.9775,pathogenic,-4.031,available,https://doi.org/10.1101/2022.10.22.513328 +T125R,NP_000537:p.Thr125Arg,"hg19,17:g.7579313G>C, hg19,17:g.7675995G>C, hg38,17:g.7675995G>C",,,0.963,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376667,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.86066,1.551431655883789,12.1966,1.4034651225776391,13.02863,7.632062561288819,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.82,E,-0.3324,0.088,-8.8733,-5.1784825919015,0.7645356027603756,Pathogenic,0.9823,pathogenic,-4.109,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T125S,NP_000537:p.Thr125Ser,"hg19,17:g.7579314T>A, hg38,17:g.7675996T>A",,,0.903,"ClinVar,saturation_mutlist",4427945,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.77588,0.9525592923164368,1.70306,1.1350027895255397,1.23947,0.9554413947627698,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.146,,,,,,,,,0.9,,True,0.9,,neutral,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.82,E,-0.278,0.088,-22.1612,-3.08982050013961,0.3440417979530826,Uncertain,0.9221,pathogenic,-3.654,available,https://doi.org/10.1101/2022.10.22.513328 +T125V,NP_000537:p.Thr125Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.61842,-0.3341947793960571,1.28061,-0.0411150577975383,0.949515,0.2886524711012308,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.82,E,-0.2599,0.088,-8.8733,-4.17323637168827,0.0704061521294842,Benign,0.9546,pathogenic,-3.56,available,https://doi.org/10.1101/2022.10.22.513328 +T125W,NP_000537:p.Thr125Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,39.60968,1.4920341968536377,15.92585,0.8833234640755774,27.767764999999997,20.24650173203779,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.82,E,-0.4144,0.088,-22.1612,-4.8590119543022,0.8073752894993366,Pathogenic,0.9964,pathogenic,-4.458,available,https://doi.org/10.1101/2022.10.22.513328 +T125Y,NP_000537:p.Thr125Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,28.86334,1.2309720516204834,8.59558,1.21892109196459,18.72946,15.041130545982295,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.146,,,,,,,,,0.9,,True,0.9,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.82,E,-0.423,0.088,-22.1612,-6.30296732646816,0.783155000924346,Pathogenic,0.9938,pathogenic,-4.187,available,https://doi.org/10.1101/2022.10.22.513328 +Y126A,NP_000537:p.Tyr126Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.98976,3.2829740047454834,3.99524,2.8668129235529696,3.9924999999999997,3.4282864617764846,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.4268,0.2714,-22.1946,-7.66884365354854,0.8707919740838916,Pathogenic,0.9931,pathogenic,-4.397,available,https://doi.org/10.1101/2022.10.22.513328 +Y126C,NP_000537:p.Tyr126Cys,"hg19,17:g.7578553T>C, hg19,17:g.7675235T>C, hg38,17:g.7675235T>C",,,0.981,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458541,Conflicting classifications of pathogenicity,1,Oncogenic,1,Tier II - Potential,1,P53 DNA-binding domain (PF00870),2.60.40.720,3.9906,2.5910961627960205,3.91973,3.3025373991366584,3.955165,3.6465686995683293,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.3975,0.2714,-22.1946,-7.66884365354854,0.8062403036546579,Pathogenic,0.8716,pathogenic,-4.087,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y126D,NP_000537:p.Tyr126Asp,"hg19,17:g.7578554A>C, hg19,17:g.7675236A>C, hg38,17:g.7675236A>C",,,0.979,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",265333,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.3403,3.2678346633911133,5.73367,3.8904283442782175,5.536985,4.615364172139109,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.441,0.2714,-22.1946,-7.66884365354854,0.8633179175907857,Pathogenic,0.995,pathogenic,-4.587,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y126E,NP_000537:p.Tyr126Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.81822,3.434512138366699,5.52245,3.5759822957404745,5.170335,4.197101147870237,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.4698,0.2714,-22.1946,-7.66884365354854,0.8707285738620218,Pathogenic,0.9985,pathogenic,-4.538,available,https://doi.org/10.1101/2022.10.22.513328 +Y126F,NP_000537:p.Tyr126Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.71266,0.5037751197814941,0.19014,0.0949466251081498,0.45139999999999997,0.40380331255407487,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,neutral,uncertain,-,uncertain,neutral,False,neutral,neutral,97.98,E,-0.1745,0.2714,-4.585,-2.13386744275084,0.0002772515298761,Benign,0.1219,benign,-3.15,available,https://doi.org/10.1101/2022.10.22.513328 +Y126G,NP_000537:p.Tyr126Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.04823,3.10996675491333,5.69966,4.561547121959059,5.373945,4.8048885609795295,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.4974,0.2714,-22.1946,-7.66884365354854,0.8620416934555737,Pathogenic,0.9882,pathogenic,-4.604,available,https://doi.org/10.1101/2022.10.22.513328 +Y126H,NP_000537:p.Tyr126His,"hg19,17:g.7578554A>G, hg19,17:g.7675236A>G, hg38,17:g.7675236A>G",,,0.961,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1734755,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.10753,2.319377899169922,2.61224,1.980958676291974,2.8598850000000002,2.544244338145987,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.3346,0.2714,-22.1946,-2.81945396308076,0.6359628940776968,Uncertain,0.9448,pathogenic,-3.986,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y126I,NP_000537:p.Tyr126Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.11159,2.984386682510376,2.98707,2.1822378652546908,2.5493300000000003,2.1469139326273456,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,uncertain,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.4389,0.2714,-22.1946,-6.81430827383659,0.8700703019115622,Pathogenic,0.9676,pathogenic,-4.286,available,https://doi.org/10.1101/2022.10.22.513328 +Y126K,NP_000537:p.Tyr126Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.74142,3.313872814178467,6.49082,3.37330816071622,5.1161200000000004,3.55736408035811,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.495,0.2714,-22.1946,-7.66884365354854,0.8514969873727171,Pathogenic,0.9984,pathogenic,-4.563,available,https://doi.org/10.1101/2022.10.22.513328 +Y126L,NP_000537:p.Tyr126Leu,"hg19,17:g.7578553_7578554delinsAG, hg38,17:g.7675235_7675236delinsAG",,,,"ClinVar,saturation_mutlist",2687703,Uncertain significance,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.75795,2.7396128177642822,4.98912,1.899011347205112,3.873535,2.328480673602556,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,uncertain,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.416,0.2714,-22.1946,-6.81430827383659,0.870614235976073,Pathogenic,0.9741,pathogenic,-4.136,available,https://doi.org/10.1101/2022.10.22.513328 +Y126M,NP_000537:p.Tyr126Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.19781,2.704299211502075,2.87755,2.136845445737171,2.03768,1.6673277228685854,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,neutral,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.3681,0.2714,-22.1946,-6.57122346242208,0.6680354864778459,Uncertain,0.9839,pathogenic,-4.146,available,https://doi.org/10.1101/2022.10.22.513328 +Y126N,NP_000537:p.Tyr126Asn,"hg19,17:g.7578554A>T, hg19,17:g.7675236A>T, hg38,17:g.7675236A>T",,,0.965,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428871,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.7426,3.136228561401367,3.9983,3.07111194348822,3.87045,3.4068559717441103,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.42,0.2714,-22.1946,-7.66884365354854,0.8703495188167917,Pathogenic,0.9806,pathogenic,-4.474,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y126P,NP_000537:p.Tyr126Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.46577,2.886382341384888,6.59524,6.6393634364419984,5.030505,5.052566718221,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.551,0.2714,-22.1946,-7.66884365354854,0.8708548471750946,Pathogenic,0.9978,pathogenic,-4.517,available,https://doi.org/10.1101/2022.10.22.513328 +Y126Q,NP_000537:p.Tyr126Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.77148,3.169559955596924,3.97143,3.050479100485721,4.371455,3.9109795502428604,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.4446,0.2714,-22.1946,-7.66884365354854,0.8699805938501821,Pathogenic,0.9972,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +Y126R,NP_000537:p.Tyr126Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.98647,2.971502780914306,5.39082,2.7338008945875645,4.688645,3.360135447293782,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.4904,0.2714,-22.1946,-7.66884365354854,0.8683791636644766,Pathogenic,0.9915,pathogenic,-4.43,available,https://doi.org/10.1101/2022.10.22.513328 +Y126S,NP_000537:p.Tyr126Ser,"hg19,17:g.7578553T>G, hg19,17:g.7675235T>G, hg38,17:g.7675235T>G",,,0.972,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1054765,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.87757,3.2665627002716064,4.81327,3.660443600891108,4.845420000000001,4.269006800445554,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.4316,0.2714,-22.1946,-7.66884365354854,0.870552189184163,Pathogenic,0.97,pathogenic,-4.328,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y126T,NP_000537:p.Tyr126Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.2945,3.1552622318267822,4.29762,2.880594268690809,4.296060000000001,3.587547134345405,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.4502,0.2714,-22.1946,-7.66884365354854,0.8706299985965237,Pathogenic,0.9914,pathogenic,-4.341,available,https://doi.org/10.1101/2022.10.22.513328 +Y126V,NP_000537:p.Tyr126Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.07675,2.80237364768982,2.96905,2.274545730104081,3.0229,2.6756478650520403,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,damaging,uncertain,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,E,-0.3606,0.2714,-8.9068,-5.01499849535105,0.8238197302987403,Pathogenic,0.9201,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328 +Y126W,NP_000537:p.Tyr126Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.55884,0.4672906398773193,0.51735,0.2307096592489849,1.038095,0.8947748296244924,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.11,,,,,,,,,16.9,P,True,16.9,1.077,uncertain,neutral,uncertain,UP,stabilizing,neutral,False,neutral,neutral,97.98,E,-0.3444,0.2714,-22.1946,-3.82078055238846,0.6037018315182043,Uncertain,0.5503,ambiguous,-4.003,available,https://doi.org/10.1101/2022.10.22.513328 +S127A,NP_000537:p.Ser127Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30095,1.9393043518066408,-1.98503,0.0713333804203553,-0.84204,0.18614169021017765,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.12,E,-0.2803,0.0001,-22.1976,-3.98743337199207,0.7575090431417312,Pathogenic,0.7237,pathogenic,-4.024,available,https://doi.org/10.1101/2022.10.22.513328 +S127C,NP_000537:p.Ser127Cys,"hg19,17:g.7578550G>C, hg19,17:g.7675232G>C, hg38,17:g.7675232G>C",,,0.916,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",219532,Pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.4813,1.5900524854660034,0.99762,1.0096889198882253,0.25815999999999995,0.2641944599441126,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3307,0.0001,-22.1976,-4.84694629009541,0.870643929777644,Pathogenic,0.8325,pathogenic,-4.26,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S127D,NP_000537:p.Ser127Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.5769,1.8299006223678589,1.78571,3.053671871676745,1.181305,1.8152859358383724,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3789,0.0001,-22.1976,-6.01309484017505,0.2845681608281866,Benign,0.9841,pathogenic,-4.194,available,https://doi.org/10.1101/2022.10.22.513328 +S127E,NP_000537:p.Ser127Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14856,2.924677610397339,1.18197,4.411043889762986,0.665265,2.279801944881493,Neutral,Uncertain,Destabilizing,Neutral,Uncertain,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3521,0.0001,-22.1976,-6.92087321066688,0.8707941460512538,Pathogenic,0.9927,pathogenic,-4.599,available,https://doi.org/10.1101/2022.10.22.513328 +S127F,NP_000537:p.Ser127Phe,"hg19,17:g.7578549_7578550delinsAA, hg19,17:g.7578550G>A, hg19,17:g.7675232G>A, hg38,17:g.7675231_7675232delinsAA, hg38,17:g.7675232G>A",,,0.925,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182928,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.21787,2.5110552310943604,3.16327,3.867025639062432,2.19057,2.542447819531216,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3583,0.0001,-22.1976,-8.07108885348846,0.8698991360516073,Pathogenic,0.9947,pathogenic,-4.348,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S127G,NP_000537:p.Ser127Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.63191,2.588038444519043,3.65272,1.8184058537894523,2.642315,1.7251579268947261,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.2894,0.0001,-22.1976,-8.07108885348846,0.8706598438544537,Pathogenic,0.9187,pathogenic,-4.212,available,https://doi.org/10.1101/2022.10.22.513328 +S127H,NP_000537:p.Ser127His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,15.44806,2.2995567321777344,3.15884,3.6503164091315896,9.30345,9.549188204565795,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3595,0.0001,-22.1976,-8.07108885348846,0.8406018380310666,Pathogenic,0.9673,pathogenic,-4.372,available,https://doi.org/10.1101/2022.10.22.513328 +S127I,NP_000537:p.Ser127Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.91453,2.3492777347564697,3.18367,2.90277704349186,3.0491,2.90865352174593,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3615,0.0001,-22.1976,-7.80031783887452,0.8651133257022714,Pathogenic,0.9853,pathogenic,-4.481,available,https://doi.org/10.1101/2022.10.22.513328 +S127K,NP_000537:p.Ser127Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.41382,2.418593406677246,3.45272,5.876308980431621,3.9332700000000003,5.145064490215811,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3689,0.0001,-22.1976,-8.07108885348846,0.8708636637510747,Pathogenic,0.999,pathogenic,-4.518,available,https://doi.org/10.1101/2022.10.22.513328 +S127L,NP_000537:p.Ser127Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.92968,2.6487133502960205,1.42279,3.1011986612721447,0.24655500000000002,1.0857593306360724,Neutral,Uncertain,Destabilizing,Neutral,Neutral,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3577,0.0001,-22.1976,-7.80031783887452,0.8250715177987141,Pathogenic,0.9614,pathogenic,-4.31,available,https://doi.org/10.1101/2022.10.22.513328 +S127M,NP_000537:p.Ser127Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.13305,2.288682222366333,2.31463,2.999988079068545,1.22384,1.5665190395342725,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3288,0.0001,-22.1976,-7.80031783887452,0.8699827092321264,Pathogenic,0.9874,pathogenic,-4.493,available,https://doi.org/10.1101/2022.10.22.513328 +S127N,NP_000537:p.Ser127Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.41074,1.2913035154342651,1.20952,2.117244818186418,0.81013,1.263992409093209,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3026,0.0001,-22.1976,-6.13697492139391,0.5822820018070793,Uncertain,0.9739,pathogenic,-4.016,available,https://doi.org/10.1101/2022.10.22.513328 +S127P,NP_000537:p.Ser127Pro,"hg19,17:g.7578551A>G, hg19,17:g.7675233A>G, hg38,17:g.7675233A>G",,,0.957,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",934410,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.68589,3.140882968902588,5.49014,5.635160306542276,5.088015,5.160525153271138,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.4337,0.0001,-22.1976,-8.07108885348846,0.8697375221032067,Pathogenic,0.9962,pathogenic,-4.434,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S127Q,NP_000537:p.Ser127Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.87245,2.492845058441162,1.59898,3.4677109300332303,2.235715,3.170080465016615,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3222,0.0001,-22.1976,-6.92087321066688,0.8706441933789701,Pathogenic,0.9913,pathogenic,-4.455,available,https://doi.org/10.1101/2022.10.22.513328 +S127R,NP_000537:p.Ser127Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.98296,2.161482572555542,3.36769,5.115103282012595,4.175325,5.049031641006298,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3741,0.0001,-22.1976,-8.07108885348846,0.8551222037805941,Pathogenic,0.9975,pathogenic,-4.486,available,https://doi.org/10.1101/2022.10.22.513328 +S127T,NP_000537:p.Ser127Thr,"hg19,17:g.7578551A>T, hg19,17:g.7675233A>T, hg38,17:g.7675233A>T",,,0.924,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",824232,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,2.32405,1.345954656600952,1.32143,1.3271547745443597,1.82274,1.82560238727218,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.086,,,,,,,,,0.0,,True,0.0,,neutral,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.2709,0.0001,-22.1976,-4.84694629009541,0.8687933864095387,Pathogenic,0.8718,pathogenic,-4.155,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S127V,NP_000537:p.Ser127Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.75913,2.487591505050659,1.03163,1.357132340486908,1.39538,1.558131170243454,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3357,0.0001,-22.1976,-7.66191715368437,0.6193876770612399,Uncertain,0.977,pathogenic,-4.348,available,https://doi.org/10.1101/2022.10.22.513328 +S127W,NP_000537:p.Ser127Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.31541,2.61291766166687,4.48265,5.079313659973262,6.39903,6.697361829986631,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.368,0.0001,-22.1976,-8.07108885348846,0.8609536105872804,Pathogenic,0.9882,pathogenic,-4.515,available,https://doi.org/10.1101/2022.10.22.513328 +S127Y,NP_000537:p.Ser127Tyr,"hg19,17:g.7578550G>T, hg19,17:g.7675232G>T, hg38,17:g.7675232G>T",,,0.918,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",656751,Pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.21305,2.803816318511963,3.55918,4.327213929611366,4.386115,4.7701319648056835,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.086,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.12,E,-0.3631,0.0001,-22.1976,-8.07108885348846,0.8176478921805082,Pathogenic,0.9839,pathogenic,-4.41,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P128A,NP_000537:p.Pro128Ala,"hg19,17:g.7578548G>C, hg38,17:g.7675230G>C",,,0.482,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.88534,0.2817409038543701,0.61837,-0.237007660136933,1.251855,0.8241661699315335,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.58,T,-0.0883,1.774,-7.3249,-1.54778559425076,0.0278393472842647,Benign,0.0757,benign,-3.248,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P128C,NP_000537:p.Pro128Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.22793,0.3971321582794189,1.38299,0.6570441963805979,1.80546,1.442487098190299,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.58,T,-0.1969,1.774,-22.1976,-3.34305849144024,0.6127975669813828,Uncertain,0.384,ambiguous,-4.118,available,https://doi.org/10.1101/2022.10.22.513328 +P128D,NP_000537:p.Pro128Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.97356,0.6360495090484619,0.78707,-0.0330093242222545,1.380315,0.9702753378888728,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.58,T,-0.2228,1.774,-22.1976,-2.9566424783071,0.1379546080351052,Benign,0.3015,benign,-3.758,available,https://doi.org/10.1101/2022.10.22.513328 +P128E,NP_000537:p.Pro128Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.68111,0.3380607366561889,0.23571,-0.376107055864695,0.9584100000000001,0.6525014720676525,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.58,T,-0.1131,1.774,-3.8655,-2.23479724546625,0.000587454165503,Benign,0.1674,benign,-3.48,available,https://doi.org/10.1101/2022.10.22.513328 +P128F,NP_000537:p.Pro128Phe,"hg19,17:g.7578547_7578548delinsAA",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.50722,0.8236813545227051,0.70442,-0.9816643072141557,1.10582,0.2627778463929222,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.58,T,-0.1575,1.774,-8.9098,-2.62455036394329,0.1079855609629131,Benign,0.4162,ambiguous,-4.019,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P128G,NP_000537:p.Pro128Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.23969,0.8512618541717529,1.51361,0.7180140615833713,1.87665,1.4788520307916857,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.58,T,-0.1786,1.774,-22.1976,-4.76465887426189,0.314696838701294,Benign,0.2599,benign,-3.76,available,https://doi.org/10.1101/2022.10.22.513328 +P128H,NP_000537:p.Pro128His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.30559,0.5939466953277588,0.27007,-0.6732787057873008,1.28783,0.8161556471063496,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.58,T,-0.203,1.774,-22.1976,-3.79622659352549,0.2813891507537747,Benign,0.155,benign,-3.721,available,https://doi.org/10.1101/2022.10.22.513328 +P128I,NP_000537:p.Pro128Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.73253,0.6496421098709106,0.97415,-0.6127514301923548,1.35334,0.5598892849038226,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.58,T,-0.1355,1.774,-7.9098,-1.26387329687304,0.4247784895544457,Uncertain,0.2671,benign,-3.908,available,https://doi.org/10.1101/2022.10.22.513328 +P128K,NP_000537:p.Pro128Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.83645,0.4831402897834778,0.68027,-0.3822987631420627,1.25836,0.7270756184289686,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.58,T,-0.1203,1.774,-6.9099,-2.97411237015459,0.0024823352041268,Benign,0.2082,benign,-3.474,available,https://doi.org/10.1101/2022.10.22.513328 +P128L,NP_000537:p.Pro128Leu,"hg19,17:g.7578547G>A, hg38,17:g.7675229G>A",,,0.501,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",824286,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.58965,0.6645100116729736,0.47109,-0.8087898252912312,1.03037,0.3904300873543844,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.58,T,-0.135,1.774,-6.9099,-2.31336388121896,0.0123665832504997,Benign,0.1109,benign,-3.627,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P128M,NP_000537:p.Pro128Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.54567,0.6455376148223877,0.90374,-0.4150145140790628,1.2247050000000002,0.5653277429604686,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.58,T,-0.1639,1.774,-22.1976,-4.15791931399236,0.7481108312588328,Pathogenic,0.2683,benign,-3.983,available,https://doi.org/10.1101/2022.10.22.513328 +P128N,NP_000537:p.Pro128Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.21496,0.7362910509109497,1.10272,-0.0551015705369906,1.65884,1.0799292147315047,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.58,T,-0.191,1.774,-22.1976,-3.37887820333769,0.2612679035161364,Benign,0.2561,benign,-3.728,available,https://doi.org/10.1101/2022.10.22.513328 +P128Q,NP_000537:p.Pro128Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.77133,0.4090940952301025,0.62177,-0.206596722090257,1.19655,0.7823666389548716,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.58,T,-0.1168,1.774,-7.3249,-2.22888658639592,0.012598301691919,Benign,0.1312,benign,-3.45,available,https://doi.org/10.1101/2022.10.22.513328 +P128R,NP_000537:p.Pro128Arg,"hg19,17:g.7578547G>C, hg38,17:g.7675229G>C",,,0.560,"ClinVar,saturation_mutlist",1718564,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.86761,0.604182779788971,0.46395,-0.5045503998860618,1.16578,0.6815298000569692,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.58,T,-0.2341,1.774,-22.1976,-4.46718637714041,0.1982005216964232,Benign,0.1368,benign,-3.764,available,https://doi.org/10.1101/2022.10.22.513328 +P128S,NP_000537:p.Pro128Ser,"hg19,17:g.7578548G>A, hg19,17:g.7675230G>A, hg38,17:g.7675230G>A",,,0.516,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2687698,Uncertain significance,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.18898,0.3418064713478088,0.7051,-0.0441187212703059,1.4470399999999999,1.072430639364847,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.58,T,-0.08,1.774,-5.74,-0.552517416553064,0.0007823254991297,Benign,0.1068,benign,-3.11,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P128T,NP_000537:p.Pro128Thr,"hg19,17:g.7578548G>T, hg38,17:g.7675230G>T",,,0.457,"ClinVar,saturation_mutlist",480743,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.16436,0.6307599544525146,0.85374,-0.1723421577022993,1.50905,0.9960089211488503,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.58,T,-0.0688,1.774,-1.182,-1.64287482783618,0.0008976628940956,Benign,0.0922,benign,-3.256,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P128V,NP_000537:p.Pro128Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.06655,0.6365947127342224,1.11122,-0.4290671750895369,1.5888849999999999,0.8187414124552315,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.58,T,-0.0828,1.774,-6.3249,-2.56557395349514,0.0083502899277511,Benign,0.1629,benign,-3.538,available,https://doi.org/10.1101/2022.10.22.513328 +P128W,NP_000537:p.Pro128Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.0525,0.7191633582115173,-0.79932,-1.3658417116423045,0.6265900000000001,0.34332914417884786,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.58,T,-0.2379,1.774,-22.1976,-4.48892609273751,0.8245128092316408,Pathogenic,0.5028,ambiguous,-4.296,available,https://doi.org/10.1101/2022.10.22.513328 +P128Y,NP_000537:p.Pro128Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.72244,0.7238297462463379,0.1966,-0.9154395053607028,0.9595199999999999,0.40350024731964856,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,52.7,,True,52.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.58,T,-0.1585,1.774,-8.9098,-3.76176556916539,0.4164728236816874,Uncertain,0.3629,ambiguous,-3.93,available,https://doi.org/10.1101/2022.10.22.513328 +A129C,NP_000537:p.Ala129Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.30053,0.2686087489128113,0.9966,0.62496191679492,0.348035,0.16221595839745998,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.0209,2.6798,-7.9098,-0.203760346780239,5.482536215743321e-07,Benign,0.2084,benign,-3.067,available,https://doi.org/10.1101/2022.10.22.513328 +A129D,NP_000537:p.Ala129Asp,"hg19,17:g.7578544G>T, hg38,17:g.7675226G>T",,,0.553,"COSMIC,ClinVar,saturation_mutlist",1735669,Benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.64252,0.4832211136817932,0.1,0.249774212973507,0.37126,0.4461471064867535,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.0757,2.6798,-2.6245,0.297108760232245,1.9028916755345464e-19,Benign,0.0679,benign,-3.05,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A129E,NP_000537:p.Ala129Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14826,0.330787718296051,0.09864,-0.0018527740330165,0.12345,0.07320361298349175,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.0547,2.6798,-1.3249,-0.243425604839551,6.691106461935032e-20,Benign,0.0903,benign,-3.0,available,https://doi.org/10.1101/2022.10.22.513328 +A129F,NP_000537:p.Ala129Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.75751,0.8624826669692993,0.30986,-0.1596833076556941,-0.223825,-0.4585966538278471,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.1439,2.6798,-22.1976,-3.6407435593294,2.995560249202388e-06,Benign,0.1479,benign,-3.204,available,https://doi.org/10.1101/2022.10.22.513328 +A129G,NP_000537:p.Ala129Gly,"hg19,17:g.7578544G>C, hg38,17:g.7675226G>C",,,0.407,"COSMIC,ClinVar,saturation_mutlist",458542,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.98517,0.7264874577522278,1.1983,0.7992820085151225,1.091735,0.8922260042575613,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.0195,2.6798,-8.9098,-1.34299511046981,2.408457670310892e-12,Benign,0.0979,benign,-2.981,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A129H,NP_000537:p.Ala129His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.24945,0.5690835118293762,0.17789,-0.1743550461768728,0.21367,0.0375474769115636,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.148,2.6798,-22.1976,-3.19244620671937,3.8001462794064563e-07,Benign,0.1559,benign,-3.062,available,https://doi.org/10.1101/2022.10.22.513328 +A129I,NP_000537:p.Ala129Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.67554,0.4748045206069946,0.08673,-0.2821600509505023,-0.794405,-0.9788500254752511,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.0495,2.6798,-5.74,-0.133191786808946,5.0755307703633486e-14,Benign,0.0928,benign,-2.86,available,https://doi.org/10.1101/2022.10.22.513328 +A129K,NP_000537:p.Ala129Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.95233,0.2529966235160827,-0.33537,-0.0732193725745083,-0.64385,-0.5127746862872542,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.0862,2.6798,-6.5879,-1.79951774257786,9.225436927515566e-13,Benign,0.1659,benign,-2.929,available,https://doi.org/10.1101/2022.10.22.513328 +A129L,NP_000537:p.Ala129Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.48523,0.2329659461975097,-0.30204,-0.5970951927868423,-0.39363499999999996,-0.5411625963934211,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.0372,2.6798,-2.4021,-0.0845640339915606,4.2163103646140345e-14,Benign,0.079,benign,-2.721,available,https://doi.org/10.1101/2022.10.22.513328 +A129M,NP_000537:p.Ala129Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.0957,0.3874288201332092,0.12925,-0.2391575328679734,-0.48322499999999996,-0.6674287664339866,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.0173,2.6798,-6.5879,-0.615773095568653,7.772171354114234e-11,Benign,0.1101,benign,-2.859,available,https://doi.org/10.1101/2022.10.22.513328 +A129N,NP_000537:p.Ala129Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.37992,0.5122148990631104,0.14116,0.0737886316553826,0.26054,0.22685431582769128,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.1459,2.6798,-22.1976,-2.3158025736854,1.2823009340421845e-08,Benign,0.0842,benign,-3.001,available,https://doi.org/10.1101/2022.10.22.513328 +A129P,NP_000537:p.Ala129Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.41781,0.9488582015037536,3.97585,3.3425451659168464,1.77902,1.4623675829584233,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.1305,2.6798,-5.588,-0.731728531667761,7.805160211007782e-11,Benign,0.1234,benign,-2.88,available,https://doi.org/10.1101/2022.10.22.513328 +A129Q,NP_000537:p.Ala129Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.00418,0.2921000123023987,0.25136,0.0307253317911154,0.12358999999999999,0.0132726658955577,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.0567,2.6798,-5.2094,-0.91649656371832,1.845597263117184e-13,Benign,0.1251,benign,-2.877,available,https://doi.org/10.1101/2022.10.22.513328 +A129R,NP_000537:p.Ala129Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.51953,0.3501096963882446,-0.02959,-0.3761920719679723,-0.27456,-0.4478610359839862,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.1765,2.6798,-22.1976,-2.80871485782904,1.2288468930040634e-06,Benign,0.1549,benign,-3.016,available,https://doi.org/10.1101/2022.10.22.513328 +A129S,NP_000537:p.Ala129Ser,"hg19,17:g.7578545C>A, hg19,17:g.7578545_7578546delinsAG, hg38,17:g.7675227C>A",,,0.475,"cBioPortal,ClinVar,saturation_mutlist",824314,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.63603,0.3095539808273315,0.37177,0.2769390003425842,0.5039,0.45648450017129205,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,94.67,T,0.0338,2.6798,-4.1025,-0.253874820879764,2.1126481285837232e-19,Benign,0.0672,benign,-2.798,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A129T,NP_000537:p.Ala129Thr,"hg19,17:g.7578545C>T, hg38,17:g.7675227C>T",,,0.438,"COSMIC,ClinVar,saturation_mutlist",482217,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.36452,0.4639636874198913,0.62313,0.0914296509290579,0.12930499999999998,-0.13654517453547105,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,0.025,2.6798,-4.662,-0.0060963391508014,2.5838406836788886e-17,Benign,0.063,benign,-2.806,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A129V,NP_000537:p.Ala129Val,"hg19,17:g.7578544G>A, hg38,17:g.7675226G>A",,,0.468,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",133280,not provided,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.62635,0.4325528144836426,0.28503,-0.1010513867126178,-0.17065999999999998,-0.3637006933563089,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,0.024,2.6798,-5.4505,-0.0124595129485265,3.643567988753419e-15,Benign,0.0707,benign,-2.794,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A129W,NP_000537:p.Ala129Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.43282,0.8148527145385742,0.5517,-0.5799474551247663,0.05943999999999999,-0.5063837275623831,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.1548,2.6798,-22.1976,-3.6407435593294,5.581959426016299e-06,Benign,0.3789,ambiguous,-3.366,available,https://doi.org/10.1101/2022.10.22.513328 +A129Y,NP_000537:p.Ala129Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.56471,0.8558621406555176,0.12517,-0.2096945385475979,-0.21977000000000002,-0.38720226927379897,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.076,,,Uncertain,,Uncertain,,,Uncertain,72.4,,True,72.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.67,T,-0.1631,2.6798,-22.1976,-3.6407435593294,1.2651315672586235e-06,Benign,0.1912,benign,-3.188,available,https://doi.org/10.1101/2022.10.22.513328 +L130A,NP_000537:p.Leu130Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.0876,2.3474624156951904,2.26769,2.8759727668366244,2.177645,2.4817863834183123,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.4173,0.0216,-22.2006,-6.18310122350225,0.7978411619877073,Pathogenic,0.7907,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +L130C,NP_000537:p.Leu130Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.65823,1.647226095199585,1.99252,2.8226981653194096,1.8253750000000002,2.240464082659705,Neutral,Uncertain,Uncertain,Neutral,Uncertain,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.4065,0.0216,-22.2006,-5.46299709915179,0.6636860614300932,Uncertain,0.8165,pathogenic,-4.175,available,https://doi.org/10.1101/2022.10.22.513328 +L130D,NP_000537:p.Leu130Asp,"hg19,17:g.7578540_7578542delinsATC, hg38,17:g.7675222_7675224delinsATC",,,,"ClinVar,saturation_mutlist",2687693,Uncertain significance,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.26183,2.552043199539185,3.79354,3.41008805656946,4.027685,3.83595902828473,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.5388,0.0216,-22.2006,-6.78499053412062,0.858974725700443,Pathogenic,0.9925,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328 +L130E,NP_000537:p.Leu130Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.71522,2.534558057785034,4.1915,3.0463403618212874,3.95336,3.3807801809106435,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.5069,0.0216,-22.2006,-6.78499053412062,0.8706378212499449,Pathogenic,0.9407,pathogenic,-4.482,available,https://doi.org/10.1101/2022.10.22.513328 +L130F,NP_000537:p.Leu130Phe,"hg19,17:g.7578542G>A, hg19,17:g.7675224G>A, hg38,17:g.7675224G>A",,,0.921,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",216466,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.06447,1.9770655632019043,3.39762,1.27273052481284,2.231045,1.16860026240642,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.3508,0.0216,-22.2006,-7.40410911027577,0.8254853971127278,Pathogenic,0.8335,pathogenic,-4.117,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L130G,NP_000537:p.Leu130Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.10768,2.7289156913757324,3.72823,4.212340595232611,3.417955,3.6600102976163056,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.4922,0.0216,-22.2006,-7.49589491350442,0.8661542266059434,Pathogenic,0.9319,pathogenic,-4.401,available,https://doi.org/10.1101/2022.10.22.513328 +L130H,NP_000537:p.Leu130His,"hg19,17:g.7578541A>T, hg38,17:g.7675223A>T",,,0.924,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",824351,Pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.9473,2.678889274597168,3.09388,2.18220634037289,2.52059,2.064753170186445,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.4597,0.0216,-22.2006,-6.63614231326096,0.8650003273198417,Pathogenic,0.916,pathogenic,-4.349,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L130I,NP_000537:p.Leu130Ile,"hg19,17:g.7578542G>T, hg38,17:g.7675224G>T",,,0.795,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.76657,1.4443717002868652,1.3915,1.3418783791368534,1.079035,1.0542241895684268,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.91,T,-0.2236,0.0216,-8.9128,-2.74581486455328,0.7005477296183987,Pathogenic,0.4647,ambiguous,-3.907,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L130K,NP_000537:p.Leu130Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.37249,2.4317986965179443,3.18299,2.9715852658743884,2.27774,2.172037632937194,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.91,T,-0.5059,0.0216,-22.2006,-5.42538959088761,0.4430372349150385,Uncertain,0.812,pathogenic,-4.132,available,https://doi.org/10.1101/2022.10.22.513328 +L130M,NP_000537:p.Leu130Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.45438,1.2557132244110107,1.5949,1.3516352691305913,1.02464,0.9030076345652956,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.91,T,-0.3147,0.0216,-22.2006,-4.69858774823902,0.7902628822701911,Pathogenic,0.4372,ambiguous,-4.036,available,https://doi.org/10.1101/2022.10.22.513328 +L130N,NP_000537:p.Leu130Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.00138,2.570324659347534,2.1034,2.400906558404085,2.05239,2.201143279202043,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.4851,0.0216,-22.2006,-6.50026027365917,0.8332563880406113,Pathogenic,0.9351,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +L130P,NP_000537:p.Leu130Pro,"hg19,17:g.7578541A>G, hg19,17:g.7675223A>G, hg38,17:g.7675223A>G",,,0.927,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428873,Pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.73139,3.040242910385132,5.33333,6.298853770842303,4.032360000000001,4.515121885421152,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.5007,0.0216,-22.2006,-7.93738882511137,0.8523211855016521,Pathogenic,0.9844,pathogenic,-4.45,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L130Q,NP_000537:p.Leu130Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.9193,2.4016804695129395,2.80646,2.2908574990972563,2.36288,2.1050787495486283,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.4381,0.0216,-22.2006,-6.10847621764913,0.5024670005899488,Uncertain,0.767,pathogenic,-4.072,available,https://doi.org/10.1101/2022.10.22.513328 +L130R,NP_000537:p.Leu130Arg,"hg19,17:g.7578541A>C, hg19,17:g.7675223A>C, hg38,17:g.7675223A>C",,,0.918,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.17226,2.5410587787628174,3.08163,2.398891483234015,2.126945,1.7855757416170075,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.4975,0.0216,-22.2006,-5.59660198154064,0.3647377200000811,Uncertain,0.6991,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L130S,NP_000537:p.Leu130Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.49389,2.497586727142334,3.11429,3.4461967186404983,2.80409,2.970043359320249,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.4477,0.0216,-22.2006,-6.36237635891577,0.8285755174767829,Pathogenic,0.926,pathogenic,-4.322,available,https://doi.org/10.1101/2022.10.22.513328 +L130T,NP_000537:p.Leu130Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.02976,2.233871459960937,1.75408,2.734589901505267,1.89192,2.3821749507526335,Uncertain,Uncertain,Destabilizing,Neutral,Uncertain,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.4204,0.0216,-22.2006,-5.24785576662641,0.4131419864471294,Uncertain,0.7858,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328 +L130V,NP_000537:p.Leu130Val,"hg19,17:g.7578542G>C, hg19,17:g.7675224G>C, hg38,17:g.7675224G>C",,,0.887,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458543,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.34614,1.7579913139343262,1.82347,1.7145550291416285,1.5848049999999998,1.5303475145708143,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.3277,0.0216,-22.2006,-3.61657390990045,0.6760825435897428,Uncertain,0.4003,ambiguous,-3.878,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L130W,NP_000537:p.Leu130Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.01782,2.287611484527588,2.10068,1.5797134936596036,1.55925,1.2987667468298016,Uncertain,Neutral,Destabilizing,Neutral,Neutral,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.4499,0.0216,-22.2006,-7.40410911027577,0.8485637363004479,Pathogenic,0.9391,pathogenic,-4.43,available,https://doi.org/10.1101/2022.10.22.513328 +L130Y,NP_000537:p.Leu130Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.33494,2.353566169738769,3.28333,1.763255240818253,2.309135,1.5490976204091265,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,False,0.135,,,,,,,,,19.4,,False,19.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.4428,0.0216,-22.2006,-7.40410911027577,0.870327727664185,Pathogenic,0.952,pathogenic,-4.394,available,https://doi.org/10.1101/2022.10.22.513328 +N131A,NP_000537:p.Asn131Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.26647,1.0007643699645996,1.93844,0.9174591896179556,2.102455,1.5919645948089778,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.14,T,-0.2323,1.048,-22.2006,-4.72321591719334,0.7620915373248979,Pathogenic,0.5899,pathogenic,-4.074,available,https://doi.org/10.1101/2022.10.22.513328 +N131C,NP_000537:p.Asn131Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.95054,0.4390813112258911,2.46939,1.191111440567765,2.209965,1.5708257202838825,Uncertain,Neutral,Neutral,Uncertain,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.14,T,-0.2822,1.048,-22.2006,-5.67942877960139,0.8109554889858922,Pathogenic,0.4411,ambiguous,-4.254,available,https://doi.org/10.1101/2022.10.22.513328 +N131D,NP_000537:p.Asn131Asp,"hg19,17:g.7578539T>C",,,0.724,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.922,1.0264768600463867,1.44694,0.573855642695947,1.18447,0.7479278213479735,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.14,T,-0.2355,1.048,-22.2006,-3.41354932165107,0.1657176542163623,Benign,0.1983,benign,-3.696,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N131E,NP_000537:p.Asn131Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.81355,1.2183585166931152,1.97381,0.8427505672417396,1.89368,1.3281502836208698,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,T,-0.2626,1.048,-22.2006,-3.52185057982921,0.3168095866603812,Benign,0.5432,ambiguous,-3.927,available,https://doi.org/10.1101/2022.10.22.513328 +N131F,NP_000537:p.Asn131Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.91404,1.020524501800537,1.81224,0.4741424753894063,1.86314,1.194091237694703,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,T,-0.2894,1.048,-22.2006,-6.0282901283126,0.8547560336858477,Pathogenic,0.9198,pathogenic,-4.405,available,https://doi.org/10.1101/2022.10.22.513328 +N131G,NP_000537:p.Asn131Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.33927,0.7073582410812378,1.62551,1.2259764696866664,1.98239,1.7826232348433333,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.14,T,-0.2631,1.048,-22.2006,-4.05784434724658,0.2933931687306382,Benign,0.2684,benign,-3.738,available,https://doi.org/10.1101/2022.10.22.513328 +N131H,NP_000537:p.Asn131His,"hg19,17:g.7578539T>G, hg38,17:g.7675221T>G",,,0.820,"COSMIC,ClinVar,saturation_mutlist",4279056,Likely pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.89521,0.6355224847793579,1.63197,0.3003773964805839,1.76359,1.097793698240292,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,T,-0.1694,1.048,-8.9128,-4.08943111458614,0.1041294796306193,Benign,0.1721,benign,-3.635,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N131I,NP_000537:p.Asn131Ile,"hg19,17:g.7578538T>A, hg19,17:g.7675220T>A, hg38,17:g.7675220T>A",,,0.939,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428902,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.44017,1.5737600326538086,5.48469,0.91750716801885,4.4624299999999995,2.178838584009425,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,T,-0.2147,1.048,-8.9128,-3.95781788600926,0.8344701937637363,Pathogenic,0.9111,pathogenic,-4.204,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N131K,NP_000537:p.Asn131Lys,"hg19,17:g.7578537G>C, hg19,17:g.7578537G>T, hg19,17:g.7675219G>T, hg38,17:g.7675219G>C, hg38,17:g.7675219G>T",3.18613394507e-05,1.1969740496e-05,"0.661, 0.662","cBioPortal,COSMIC,ClinVar,saturation_mutlist",246429,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.28355,0.7324209809303284,1.29966,0.5482732930356107,1.2916050000000001,0.9159116465178053,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,T,-0.1261,1.048,-0.7631,-2.08630271146585,0.000455846416919,Benign,0.3836,ambiguous,-3.306,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N131L,NP_000537:p.Asn131Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.11183,0.9392035007476808,1.74898,0.4401097957384681,1.930405,1.275969897869234,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,T,-0.289,1.048,-22.2006,-5.99081550010343,0.8174109132435935,Pathogenic,0.7251,pathogenic,-4.24,available,https://doi.org/10.1101/2022.10.22.513328 +N131M,NP_000537:p.Asn131Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.15823,0.9039599299430848,1.85068,0.7118447377275863,2.004455,1.4350373688637932,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,T,-0.2431,1.048,-22.2006,-5.99081550010343,0.8679322680569956,Pathogenic,0.7767,pathogenic,-4.232,available,https://doi.org/10.1101/2022.10.22.513328 +N131P,NP_000537:p.Asn131Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.92926,2.4289586544036865,19.89558,3.2471562643228333,11.91242,3.5882081321614168,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.14,T,-0.3979,1.048,-22.2006,-6.80979896597955,0.8262655352400875,Pathogenic,0.9555,pathogenic,-4.241,available,https://doi.org/10.1101/2022.10.22.513328 +N131Q,NP_000537:p.Asn131Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.61333,0.7757595777511597,0.87041,0.8385190331014533,1.24187,1.2259245165507267,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,T,-0.2262,1.048,-22.2006,-3.50227611843883,0.3397015314576345,Uncertain,0.3629,ambiguous,-3.716,available,https://doi.org/10.1101/2022.10.22.513328 +N131R,NP_000537:p.Asn131Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.79372,0.924961268901825,1.49762,0.4177817517820809,1.64567,1.1057508758910404,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,T,-0.2676,1.048,-22.2006,-3.13973064079933,0.0488833239309097,Benign,0.3838,ambiguous,-3.655,available,https://doi.org/10.1101/2022.10.22.513328 +N131S,NP_000537:p.Asn131Ser,"hg19,17:g.7578538T>C, hg19,17:g.7675220T>C, hg38,17:g.7675220T>C",,,0.859,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1057941,Uncertain significance,2,Uncertain significance,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.25286,0.8173407316207886,2.05646,0.8876567591810802,2.15466,1.5702583795905403,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.14,T,-0.2022,1.048,-22.2006,-5.06631023309027,0.6703594710432845,Uncertain,0.1566,benign,-3.734,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N131T,NP_000537:p.Asn131Thr,"hg19,17:g.7578538T>G, hg19,17:g.7675220T>G, hg38,17:g.7675220T>G",,,0.907,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.8243,1.4841598272323608,2.7415,1.1005355048900656,2.7828999999999997,1.9624177524450328,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.14,T,-0.1788,1.048,-7.9128,-3.83700919409569,0.4061077091461031,Uncertain,0.5533,ambiguous,-3.682,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N131V,NP_000537:p.Asn131Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.49101,1.4453561305999756,5.39116,0.91359503119266,4.441085,2.20230251559633,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,T,-0.2759,1.048,-22.2006,-5.99081550010343,0.8488199363520148,Pathogenic,0.8591,pathogenic,-4.327,available,https://doi.org/10.1101/2022.10.22.513328 +N131W,NP_000537:p.Asn131Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.74985,1.1602953672409058,1.82075,0.3483374562036306,2.2853,1.5490937281018153,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,T,-0.2945,1.048,-22.2006,-6.0282901283126,0.8675843250247417,Pathogenic,0.9305,pathogenic,-4.434,available,https://doi.org/10.1101/2022.10.22.513328 +N131Y,NP_000537:p.Asn131Tyr,"hg19,17:g.7578539T>A, hg38,17:g.7675221T>A",,,0.879,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141988,Pathogenic,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.89041,1.1812154054641724,1.63571,0.4638181768337324,1.7630599999999998,1.1771140884168663,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.161,,,Uncertain,,Uncertain,,,Uncertain,60.3,,False,60.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.14,T,-0.273,1.048,-22.2006,-6.0282901283126,0.8601617533056554,Pathogenic,0.5291,ambiguous,-4.3,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132A,NP_000537:p.Lys132Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42335,0.5253428220748901,1.09932,1.8019929802948769,1.2613349999999999,1.6126714901474384,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.3173,0.0546,-22.2036,-7.8200062696862,0.8696162209505763,Pathogenic,0.9962,pathogenic,-4.349,available,https://doi.org/10.1101/2022.10.22.513328 +K132C,NP_000537:p.Lys132Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.98451,0.8178552985191345,0.78163,2.1382560120598515,0.88307,1.5613830060299256,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.3875,0.0546,-22.2036,-7.8200062696862,0.8561700127366381,Pathogenic,0.9951,pathogenic,-4.4,available,https://doi.org/10.1101/2022.10.22.513328 +K132D,NP_000537:p.Lys132Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.42377,2.4787395000457764,4.40952,3.4450720327311446,4.416645,3.9344210163655724,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.4263,0.0546,-22.2036,-7.55769165067509,0.8650643816746928,Pathogenic,0.9994,pathogenic,-4.566,available,https://doi.org/10.1101/2022.10.22.513328 +K132E,NP_000537:p.Lys132Glu,"hg19,17:g.7578536T>C, hg19,17:g.7675218T>C, hg38,17:g.7675218T>C",,3.988544899e-06,0.968,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376626,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.60939,1.4018800258636477,2.00918,2.975549681798076,2.809285,3.292469840899038,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.3422,0.0546,-22.2036,-7.55769165067509,0.8705558087392056,Pathogenic,0.9978,pathogenic,-4.469,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132F,NP_000537:p.Lys132Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.17006,1.403101682662964,1.01599,0.8708464718465738,5.593025,5.520453235923287,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.1,E,-0.3884,0.0546,-22.2036,-7.8200062696862,0.8657937953296413,Pathogenic,0.9995,pathogenic,-4.628,available,https://doi.org/10.1101/2022.10.22.513328 +K132G,NP_000537:p.Lys132Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.3592,1.969999074935913,3.53707,3.5391276726695486,3.4481349999999997,3.4491638363347743,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.3765,0.0546,-22.2036,-7.8200062696862,0.8701981039720101,Pathogenic,0.9969,pathogenic,-4.455,available,https://doi.org/10.1101/2022.10.22.513328 +K132H,NP_000537:p.Lys132His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.17761,1.446508288383484,2.23061,1.889570868871352,2.70411,2.533590434435676,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.3274,0.0546,-22.2036,-7.8200062696862,0.8696605699344608,Pathogenic,0.9837,pathogenic,-4.38,available,https://doi.org/10.1101/2022.10.22.513328 +K132I,NP_000537:p.Lys132Ile,"hg19,17:g.7578534_7578535delinsAA",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.77935,0.650375247001648,-0.34014,0.6241771879282706,0.219605,0.7017635939641353,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.1,E,-0.3556,0.0546,-22.2036,-6.84932683484845,0.8703343017234512,Pathogenic,0.997,pathogenic,-4.503,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132L,NP_000537:p.Lys132Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.86729,0.5655912160873413,0.32143,0.1837954624582699,-0.27293,-0.34174726877086503,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.1,E,-0.3543,0.0546,-22.2036,-6.84932683484845,0.8679826758186007,Pathogenic,0.9933,pathogenic,-4.296,available,https://doi.org/10.1101/2022.10.22.513328 +K132M,NP_000537:p.Lys132Met,"hg19,17:g.7578535T>A, hg19,17:g.7675217T>A, hg38,17:g.7675217T>A",,,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376629,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.77786,0.2876050472259521,-0.26565,0.8195716890625115,-0.521755,0.020855844531255774,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.2515,0.0546,-7.3309,-3.94411653735206,0.144850327736009,Benign,0.9874,pathogenic,-3.86,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132N,NP_000537:p.Lys132Asn,"hg19,17:g.7578534C>A, hg19,17:g.7578534C>G, hg19,17:g.7675216C>A, hg19,17:g.7675216C>G, hg38,17:g.7675216C>A, hg38,17:g.7675216C>G",,,,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","634773, 376624","Pathogenic/Likely pathogenic, Likely pathogenic","2, 3","Oncogenic, Likely oncogenic","1, 1",Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,3.11745,1.7999732494354248,2.08299,2.1852973089391563,2.60022,2.651373654469578,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.3355,0.0546,-22.2036,-7.55769165067509,0.8708643304763221,Pathogenic,0.9987,pathogenic,-4.171,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132P,NP_000537:p.Lys132Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.66506,2.392385721206665,9.35748,7.527384347678499,10.01127,9.09622217383925,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.4916,0.0546,-22.2036,-7.8200062696862,0.8708435253115391,Pathogenic,0.9989,pathogenic,-4.525,available,https://doi.org/10.1101/2022.10.22.513328 +K132Q,NP_000537:p.Lys132Gln,"hg19,17:g.7578536T>G, hg19,17:g.7675218T>G, hg38,17:g.7675218T>G",,,0.944,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376628,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.55058,0.2555861473083496,0.73537,1.961162319162238,1.142975,1.755871159581119,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.3165,0.0546,-22.2036,-7.55769165067509,0.3046919840954846,Benign,0.9807,pathogenic,-3.852,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132R,NP_000537:p.Lys132Arg,"hg19,17:g.7578535T>C, hg19,17:g.7675217T>C, hg38,17:g.7675217T>C",,0.0,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376625,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.5917,0.0997552871704101,0.2881,1.3222180599419002,0.4399,0.9569590299709501,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.1,E,-0.2509,0.0546,-22.2036,-4.12552491681601,0.1713027627812074,Benign,0.5077,ambiguous,-3.498,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132S,NP_000537:p.Lys132Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.79271,1.015700340270996,2.33878,2.6665681799285927,2.5657449999999997,2.729639089964296,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.3274,0.0546,-22.2036,-7.8200062696862,0.8628055962212964,Pathogenic,0.9982,pathogenic,-4.299,available,https://doi.org/10.1101/2022.10.22.513328 +K132T,NP_000537:p.Lys132Thr,"hg19,17:g.7578535T>G, hg19,17:g.7675217T>G, hg38,17:g.7675217T>G",,,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376627,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.78647,0.8433045148849487,0.72925,1.824811569435242,0.75786,1.305640784717621,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.3393,0.0546,-22.2036,-7.8200062696862,0.8707351252137716,Pathogenic,0.9872,pathogenic,-4.13,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132V,NP_000537:p.Lys132Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48638,0.6684712171554565,-0.2,0.6396682318877558,0.14318999999999998,0.5630241159438779,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.1,E,-0.3395,0.0546,-22.2036,-4.6401008462263,0.863384336316444,Pathogenic,0.9928,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328 +K132W,NP_000537:p.Lys132Trp,"hg38,17:g.7675217_7675218delinsCA",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.2371,1.3396844863891602,0.77959,1.2132633074007009,4.508345,4.72518165370035,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.1,E,-0.3974,0.0546,-22.2036,-7.8200062696862,0.8686634137297546,Pathogenic,0.9994,pathogenic,-4.561,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K132Y,NP_000537:p.Lys132Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.37041,1.5524260997772217,1.25204,1.3652603698949106,5.311225,5.367835184947455,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.149,,,,,,,,,8.1,,False,8.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.1,E,-0.3733,0.0546,-22.2036,-7.8200062696862,0.8604811615588429,Pathogenic,0.9976,pathogenic,-4.567,available,https://doi.org/10.1101/2022.10.22.513328 +M133A,NP_000537:p.Met133Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.24069,2.196798324584961,2.91463,1.7111927939592977,3.07766,2.475941396979649,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.31,E,-0.3734,0.306,-22.2066,-6.76749764248868,5.9338488819333425e-09,Benign,0.8922,pathogenic,-3.085,available,https://doi.org/10.1101/2022.10.22.513328 +M133C,NP_000537:p.Met133Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.89218,1.4816285371780396,2.68367,1.8736419902264825,2.7879250000000004,2.3829109951132414,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,damaging,98.31,E,-0.3789,0.306,-22.2066,-6.95369664079319,4.197190326739781e-05,Benign,0.8983,pathogenic,-3.449,available,https://doi.org/10.1101/2022.10.22.513328 +M133D,NP_000537:p.Met133Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.69133,3.496072769165039,4.99184,2.509359923824881,4.341585,3.10034496191244,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.31,E,-0.4848,0.306,-22.2066,-7.34409950369429,0.0001930909298142,Benign,0.9987,pathogenic,-3.706,available,https://doi.org/10.1101/2022.10.22.513328 +M133E,NP_000537:p.Met133Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.47108,3.317757129669189,3.30986,1.8798131238384577,3.39047,2.675446561919229,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.31,E,-0.475,0.306,-22.2066,-7.34409950369429,5.66832045679349e-05,Benign,0.9916,pathogenic,-3.597,available,https://doi.org/10.1101/2022.10.22.513328 +M133F,NP_000537:p.Met133Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01612,0.6197390556335449,0.44864,0.3142144872313918,0.23238,0.1651672436156959,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.31,E,-0.3784,0.306,-22.2066,-7.34409950369429,6.135065389835606e-06,Benign,0.7425,pathogenic,-3.05,available,https://doi.org/10.1101/2022.10.22.513328 +M133G,NP_000537:p.Met133Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.90271,3.425262928009033,4.96088,3.4269726134315195,4.931795,4.1648413067157595,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.31,E,-0.4543,0.306,-22.2066,-7.34409950369429,1.7790310131268225e-05,Benign,0.9764,pathogenic,-3.614,available,https://doi.org/10.1101/2022.10.22.513328 +M133H,NP_000537:p.Met133His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.18009,2.983539581298828,2.61463,1.2387955403176338,2.89736,2.209442770158817,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.31,E,-0.4317,0.306,-22.2066,-7.34409950369429,5.238552256164728e-06,Benign,0.9849,pathogenic,-3.41,available,https://doi.org/10.1101/2022.10.22.513328 +M133I,NP_000537:p.Met133Ile,"hg19,17:g.7578531C>A, hg19,17:g.7578531C>T, hg38,17:g.7675213C>A, hg38,17:g.7675213C>G, hg38,17:g.7675213C>T",,7.9728286001e-06,"0.477, 0.479","cBioPortal,COSMIC,ClinVar,saturation_mutlist",421437,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.40596,-0.3501880168914795,0.87789,-0.19577284659053,1.141925,0.6050935767047351,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.31,E,-0.2907,0.306,-22.2066,-3.928979085432,1.6468697728704282e-11,Benign,0.5785,pathogenic,-2.818,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M133K,NP_000537:p.Met133Lys,"hg19,17:g.7578532A>T, hg19,17:g.7675214A>T, hg38,17:g.7675214A>T",,,0.845,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2430159,Uncertain significance,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.01672,3.3716397285461426,3.65782,1.86172159674558,2.83727,1.9392207983727898,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.31,E,-0.4359,0.306,-22.2066,-7.34409950369429,4.2256231316959206e-06,Benign,0.9651,pathogenic,-3.424,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M133L,NP_000537:p.Met133Leu,"hg19,17:g.7578533T>A, hg38,17:g.7675215T>A, hg38,17:g.7675215T>G",,,0.426,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.14833,-0.1865317821502685,-0.11973,-0.5139656340492071,-0.13402999999999998,-0.33114781702460355,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.31,E,-0.1447,0.306,-0.0765,-0.324119412855083,6.554492214307761e-33,Benign,0.0735,benign,-2.846,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M133N,NP_000537:p.Met133Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.84843,3.2526402473449707,3.10952,1.71186717796481,3.478975,2.780148588982405,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.31,E,-0.4265,0.306,-22.2066,-7.34409950369429,4.40367552830072e-06,Benign,0.9848,pathogenic,-3.478,available,https://doi.org/10.1101/2022.10.22.513328 +M133P,NP_000537:p.Met133Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.47911,3.635742664337158,5.61769,5.965255012540163,5.5484,5.722182506270082,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.31,E,-0.5443,0.306,-22.2066,-7.34409950369429,8.462734934672547e-06,Benign,0.9952,pathogenic,-3.456,available,https://doi.org/10.1101/2022.10.22.513328 +M133Q,NP_000537:p.Met133Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.9604,2.8155388832092285,1.53537,1.3779208401170346,2.247885,2.1691604200585175,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.31,E,-0.4185,0.306,-22.2066,-7.34409950369429,4.280071402143997e-05,Benign,0.9499,pathogenic,-3.442,available,https://doi.org/10.1101/2022.10.22.513328 +M133R,NP_000537:p.Met133Arg,"hg19,17:g.7578532A>C, hg19,17:g.7675214A>C, hg38,17:g.7675214A>C",,,0.849,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2687699,Uncertain significance,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.72127,2.989412307739258,4.17789,1.0379969427154403,3.44958,1.87963347135772,Uncertain,Uncertain,Destabilizing,Destabilizing,Neutral,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.31,E,-0.4632,0.306,-22.2066,-7.34409950369429,8.413985349902001e-05,Benign,0.969,pathogenic,-3.322,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M133S,NP_000537:p.Met133Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.49422,3.1008286476135254,3.60578,2.404334009142357,4.050000000000001,3.4492770045711785,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.31,E,-0.4048,0.306,-22.2066,-6.95369664079319,3.706710179197653e-05,Benign,0.9731,pathogenic,-3.43,available,https://doi.org/10.1101/2022.10.22.513328 +M133T,NP_000537:p.Met133Thr,"hg19,17:g.7578532A>G, hg38,17:g.7675214A>G",,,0.780,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12357,Pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.20119,2.478238582611084,2.35102,1.3991401913260006,2.7761050000000003,2.3001650956630004,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.31,E,-0.3445,0.306,-22.2066,-6.95369664079319,7.756525062442728e-06,Benign,0.9114,pathogenic,-3.284,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M133V,NP_000537:p.Met133Val,"hg19,17:g.7578533T>C, hg38,17:g.7675215T>C",,3.9868275219e-06,0.503,"COSMIC,ClinVar,saturation_mutlist",528246,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.27506,0.4536886215209961,0.35034,0.1386630053751342,0.8127,0.7068615026875671,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.31,E,-0.2549,0.306,-8.9187,-3.96856910757131,1.7018556235446606e-13,Benign,0.2123,benign,-2.795,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M133W,NP_000537:p.Met133Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.46319,1.909306883811951,1.26054,0.2074389915291835,0.861865,0.3353144957645917,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.31,E,-0.4412,0.306,-22.2066,-7.34409950369429,8.286633640167262e-06,Benign,0.9727,pathogenic,-3.516,available,https://doi.org/10.1101/2022.10.22.513328 +M133Y,NP_000537:p.Met133Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.47142,2.0131397247314453,1.4034,0.7631805643298889,0.93741,0.6173002821649445,Neutral,Neutral,Destabilizing,Neutral,Neutral,True,0.24,,,,,,,,,1.1,,False,1.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.31,E,-0.4207,0.306,-22.2066,-7.34409950369429,5.656324993536331e-06,Benign,0.9556,pathogenic,-3.386,available,https://doi.org/10.1101/2022.10.22.513328 +F134A,NP_000537:p.Phe134Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.31762,2.74796724319458,4.1534,4.67223783705031,4.23551,4.494928918525154,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.413,-0.0436,,,0.18965,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.369,0.8705,-22.2066,-7.13917580462256,0.868115606021729,Pathogenic,0.9995,pathogenic,-4.424,available,https://doi.org/10.1101/2022.10.22.513328 +F134C,NP_000537:p.Phe134Cys,"hg19,17:g.7578529A>C, hg19,17:g.7675211A>C, hg38,17:g.7675211A>C",,3.9849845781e-06,0.949,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",230477,Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.69597,1.8721954822540283,4.07517,4.7404841551225125,3.88557,4.218227077561256,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.413,-0.04708,-0.18309,Neutral,0.06213,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.3372,0.8705,-22.2066,-7.13917580462256,0.8568063888549966,Pathogenic,0.9992,pathogenic,-4.18,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F134D,NP_000537:p.Phe134Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.13395,2.65077543258667,5.6466,5.475173853599224,5.390275,5.304561926799612,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.413,0.37564,,,0.65828,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.492,0.8705,-22.2066,-7.13917580462256,0.869659588137159,Pathogenic,0.9995,pathogenic,-4.617,available,https://doi.org/10.1101/2022.10.22.513328 +F134E,NP_000537:p.Phe134Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.08199,2.61784291267395,5.51871,5.181896785204035,5.30035,5.131943392602018,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.413,0.275,,,0.49089,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.4614,0.8705,-22.2066,-7.13917580462256,0.8704013923774918,Pathogenic,0.9998,pathogenic,-4.665,available,https://doi.org/10.1101/2022.10.22.513328 +F134G,NP_000537:p.Phe134Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.94795,2.7678210735321045,6.43231,6.477782463888344,6.19013,6.212866231944172,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.413,-0.00202,,,0.23748,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.4044,0.8705,-22.2066,-7.13917580462256,0.8629705170552813,Pathogenic,0.9994,pathogenic,-4.536,available,https://doi.org/10.1101/2022.10.22.513328 +F134H,NP_000537:p.Phe134His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.00049,1.992016077041626,3.05612,2.7676880839864624,3.028305,2.8840890419932315,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,True,0.413,-0.04216,,,0.1654,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.3966,0.8705,-22.2066,-4.28611797678312,0.8674635262703196,Pathogenic,0.9971,pathogenic,-4.123,available,https://doi.org/10.1101/2022.10.22.513328 +F134I,NP_000537:p.Phe134Ile,"hg19,17:g.7578530A>T, hg38,17:g.7675212A>T",,,0.955,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480953,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.33935,1.954028367996216,2.41463,2.8485641730866016,2.37699,2.593957086543301,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.413,0.32138,0.08784,Neutral,0.03226,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.313,0.8705,-22.2066,-6.89973504256994,0.8705290292679408,Pathogenic,0.9978,pathogenic,-4.28,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F134K,NP_000537:p.Phe134Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.17534,2.708505630493164,7.82823,5.531341544165942,6.001785,4.853340772082971,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.413,-0.13324,,,0.20599,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.4682,0.8705,-22.2066,-7.13917580462256,0.8627164969176122,Pathogenic,0.9998,pathogenic,-4.527,available,https://doi.org/10.1101/2022.10.22.513328 +F134L,NP_000537:p.Phe134Leu,"hg19,17:g.7578528A>C, hg19,17:g.7578528A>T, hg19,17:g.7578530A>G, hg19,17:g.7675210A>T, hg19,17:g.7675212A>G, hg38,17:g.7675210A>C, hg38,17:g.7675210A>T, hg38,17:g.7675212A>G",,,"0.872, 0.942","cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","1018290, 871293, 80710","Uncertain significance, Conflicting classifications of pathogenicity, Uncertain significance","1, 1, 1",Likely oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,2.30751,2.0256335735321045,1.56156,2.2873334162634404,1.9345350000000001,2.2974217081317203,Uncertain,Uncertain,Destabilizing,Neutral,Uncertain,True,0.413,-0.12702,-0.21141,Neutral,0.01576,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.2751,0.8705,-22.2066,-6.01506292260617,0.8618877313062725,Pathogenic,0.9996,pathogenic,-3.916,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F134M,NP_000537:p.Phe134Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.07965,1.935039520263672,2.58163,2.6958566176224883,1.83064,1.8877533088112441,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.413,-0.0775,,,0.01984,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.3061,0.8705,-22.2066,-6.89973504256994,0.8641042152085098,Pathogenic,0.9989,pathogenic,-4.184,available,https://doi.org/10.1101/2022.10.22.513328 +F134N,NP_000537:p.Phe134Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.83369,2.6896395683288574,4.37075,4.272288561739824,4.10222,4.052989280869912,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.413,0.02476,,,0.13935,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.4217,0.8705,-22.2066,-7.13917580462256,0.8379188085896098,Pathogenic,0.9984,pathogenic,-4.242,available,https://doi.org/10.1101/2022.10.22.513328 +F134P,NP_000537:p.Phe134Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.9265,2.504381895065308,6.10952,7.974477993853637,6.01801,6.950488996926818,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.413,-0.08264,,,0.20901,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.4924,0.8705,-22.2066,-7.13917580462256,0.8595313422714179,Pathogenic,0.9999,pathogenic,-4.601,available,https://doi.org/10.1101/2022.10.22.513328 +F134Q,NP_000537:p.Phe134Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.33178,2.6586358547210693,4.28878,4.282986225418185,3.81028,3.8073831127090925,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.413,-0.06612,,,0.09851,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.4237,0.8705,-22.2066,-7.13917580462256,0.8699252067211151,Pathogenic,0.9998,pathogenic,-4.395,available,https://doi.org/10.1101/2022.10.22.513328 +F134R,NP_000537:p.Phe134Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.1723,2.4710230827331543,7.87483,4.588457686938663,7.023565,5.380378843469332,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.413,-0.24168,,,0.26473,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.4696,0.8705,-22.2066,-7.13917580462256,0.8673618541935252,Pathogenic,0.9991,pathogenic,-4.368,available,https://doi.org/10.1101/2022.10.22.513328 +F134S,NP_000537:p.Phe134Ser,"hg19,17:g.7578529A>G, hg19,17:g.7675211A>G, hg38,17:g.7675211A>G",,,0.942,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1519634,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.35708,2.6933629512786865,5.33333,5.574222099623999,5.345205,5.465651049811999,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.413,-0.05128,-0.13609,Neutral,0.19088,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.348,0.8705,-22.2066,-7.13917580462256,0.8626046487774373,Pathogenic,0.9992,pathogenic,-4.314,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F134T,NP_000537:p.Phe134Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.08895,2.474257707595825,4.4966,4.763483960923601,4.292775,4.426216980461801,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.413,-0.01494,,,0.11102,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.3943,0.8705,-22.2066,-7.13917580462256,0.8674723279839714,Pathogenic,0.9997,pathogenic,-4.344,available,https://doi.org/10.1101/2022.10.22.513328 +F134V,NP_000537:p.Phe134Val,"hg19,17:g.7578530A>C, hg19,17:g.7675212A>C, hg38,17:g.7675212A>C",,,0.959,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",988615,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.9139,2.215014934539795,2.93401,3.2528472151952825,2.923955,3.0833736075976415,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,True,0.413,-0.0346,0.45548,Neutral,0.10633,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.5,E,-0.3073,0.8705,-22.2066,-6.89973504256994,0.8650574421560595,Pathogenic,0.9977,pathogenic,-4.276,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F134W,NP_000537:p.Phe134Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.44343,0.7094740867614746,1.44218,1.2095656021936818,1.442805,1.326497801096841,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.413,-0.03896,,,0.20944,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.5,E,-0.2926,0.8705,-22.2066,-4.28611797678312,0.8662794954303654,Pathogenic,0.964,pathogenic,-4.284,available,https://doi.org/10.1101/2022.10.22.513328 +F134Y,NP_000537:p.Phe134Tyr,"hg19,17:g.7578529A>T, hg38,17:g.7675211A>T",,,0.637,"ClinVar,saturation_mutlist",1509393,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.51892,0.0394787788391113,0.90952,0.8616772200992792,1.21422,1.1902986100496395,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.413,-0.0777,-0.0897,Neutral,0.50439,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.5,E,-0.1501,0.8705,-0.4968,-1.865470728872,6.06060541571613e-06,Benign,0.4046,ambiguous,-2.968,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135A,NP_000537:p.Cys135Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.66604,0.4982993602752685,0.28197,0.4373070227466985,0.474005,0.5516735113733493,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.535,-0.0002,,,-0.00188,Neutral,0.0,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.18,E,-0.4923,0.0001,-22.2066,-3.63717197669355,0.4580950570525748,Uncertain,0.9583,pathogenic,-4.07,available,https://doi.org/10.1101/2022.10.22.513328 +C135D,NP_000537:p.Cys135Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.94017,2.744013786315918,3.22449,1.8418260035899432,3.08233,2.390998001794972,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.535,0.35796,,,-0.06212,Neutral,0.0034,,,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.18,E,-0.5996,0.0001,-22.2066,-7.76909942258231,0.8336369045825085,Pathogenic,0.9998,pathogenic,-4.824,available,https://doi.org/10.1101/2022.10.22.513328 +C135E,NP_000537:p.Cys135Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.12783,2.190840482711792,3.40986,1.712917648963648,3.7688450000000002,2.9203738244818243,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.535,0.32854,,,-0.04091,Neutral,0.00361,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.5872,0.0001,-22.2066,-7.76909942258231,0.8523294015886864,Pathogenic,0.9999,pathogenic,-4.882,available,https://doi.org/10.1101/2022.10.22.513328 +C135F,NP_000537:p.Cys135Phe,"hg19,17:g.7578525_7578526delinsAA, hg19,17:g.7578526C>A, hg19,17:g.7675208C>A, hg38,17:g.7675208C>A",,,0.960,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376559,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,9.21435,0.9670093655586244,1.82279,1.0887167878578103,5.5185699999999995,5.151533393928905,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,True,0.535,0.02192,0.24397,Neutral,0.01866,Neutral,0.00585,-0.10001,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.4863,0.0001,-22.2066,-7.76909942258231,0.8197195351106296,Pathogenic,0.986,pathogenic,-4.44,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135G,NP_000537:p.Cys135Gly,"hg19,17:g.7578527A>C, hg19,17:g.7675209A>C, hg38,17:g.7675209A>C",,,0.965,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376563,Pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.20546,1.7132941484451294,2.19218,2.130927563655324,2.19882,2.1681937818276618,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.535,0.0217,0.04386,Neutral,0.00391,Neutral,0.0,0.13637,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.18,E,-0.4848,0.0001,-22.2066,-7.19112192806731,0.8412958068476148,Pathogenic,0.9352,pathogenic,-4.515,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135H,NP_000537:p.Cys135His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.16389,1.8733528852462769,2.6619,1.5408446451440545,5.412895000000001,4.852367322572027,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.535,0.0,,,-0.00063,Neutral,0.0,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.5981,0.0001,-22.2066,-7.76909942258231,0.8467471373750963,Pathogenic,0.999,pathogenic,-4.676,available,https://doi.org/10.1101/2022.10.22.513328 +C135I,NP_000537:p.Cys135Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.14408,-0.2333220243453979,1.13571,-0.1311142996609082,0.495815,-0.13759714983045412,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.535,-0.0001,,,0.0,Neutral,0.0,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.5162,0.0001,-22.2066,-4.77824995041311,0.4426942348457688,Uncertain,0.9614,pathogenic,-4.046,available,https://doi.org/10.1101/2022.10.22.513328 +C135K,NP_000537:p.Cys135Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.23898,1.8595744371414185,5.55816,3.79625838721914,5.398569999999999,4.51761919360957,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.535,-0.1646,,,0.01611,Neutral,-0.03525,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.5878,0.0001,-22.2066,-7.76909942258231,0.8643058448763606,Pathogenic,0.9999,pathogenic,-4.762,available,https://doi.org/10.1101/2022.10.22.513328 +C135L,NP_000537:p.Cys135Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.32169,0.6401631832122803,1.28605,0.1774273691250572,0.80387,0.24955868456252858,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.535,-0.0196,,,-0.00108,Neutral,0.0,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.5493,0.0001,-22.2066,-5.24580571604154,0.8485371855670276,Pathogenic,0.9613,pathogenic,-4.178,available,https://doi.org/10.1101/2022.10.22.513328 +C135M,NP_000537:p.Cys135Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.07957,0.5753370523452759,-0.29966,0.8176353935391009,-0.18961499999999998,0.3690326967695504,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.535,-0.00086,,,0.0,Neutral,0.00013,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.5165,0.0001,-22.2066,-5.14118386430122,0.8258066705361237,Pathogenic,0.9913,pathogenic,-4.282,available,https://doi.org/10.1101/2022.10.22.513328 +C135N,NP_000537:p.Cys135Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.64563,2.300500869750977,1.21803,1.0771761874136347,0.9318299999999999,0.8614030937068173,Neutral,Neutral,Destabilizing,Neutral,Neutral,True,0.535,0.0001,,,0.0,Neutral,-0.02328,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.542,0.0001,-22.2066,-7.76909942258231,0.8479744749952804,Pathogenic,0.9981,pathogenic,-4.6,available,https://doi.org/10.1101/2022.10.22.513328 +C135P,NP_000537:p.Cys135Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.29523,2.0257644653320312,3.81463,5.471947305914757,3.05493,3.8835886529573784,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.535,-0.0298,,,-0.01192,Neutral,0.0,,,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.18,E,-0.6107,0.0001,-22.2066,-7.76909942258231,0.8608869238756596,Pathogenic,0.9992,pathogenic,-4.755,available,https://doi.org/10.1101/2022.10.22.513328 +C135Q,NP_000537:p.Cys135Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.38978,1.6634924411773682,1.78741,1.4092407261228594,2.5885949999999998,2.3995103630614296,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.535,-0.00292,,,0.00083,Neutral,-0.00161,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.566,0.0001,-22.2066,-7.76909942258231,0.8569851786578213,Pathogenic,0.9992,pathogenic,-4.697,available,https://doi.org/10.1101/2022.10.22.513328 +C135R,NP_000537:p.Cys135Arg,"hg19,17:g.7578527A>G, hg19,17:g.7675209A>G, hg38,17:g.7675209A>G",,,0.964,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376560,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.2978,1.8000115156173706,6.53333,2.9468589682393778,9.415565,7.622329484119689,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.535,-0.21228,0.02773,Neutral,0.03426,Neutral,-0.03318,-0.06153,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.5446,0.0001,-22.2066,-7.76909942258231,0.8382912015293101,Pathogenic,0.9978,pathogenic,-4.565,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135S,NP_000537:p.Cys135Ser,"hg19,17:g.7578526C>G, hg19,17:g.7578527A>T, hg19,17:g.7675208C>G, hg38,17:g.7675208C>G, hg38,17:g.7675209A>T",,,"0.954, 0.957","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","3893309, 376562","Likely pathogenic, Conflicting classifications of pathogenicity","1, 1",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.64409,1.0674628019332886,1.2119,1.293380420259589,0.927995,0.9687352101297946,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.535,0.0,0.04819,Neutral,-0.00188,Neutral,4e-05,0.02967,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.18,E,-0.4831,0.0001,-22.2066,-4.68415718676229,0.8702095371151793,Pathogenic,0.958,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135T,NP_000537:p.Cys135Thr,"hg38,17:g.7675208_7675210delinsGTG",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.07043,0.4916770458221435,0.52313,0.5479934566307323,-0.27365,-0.26121827168463385,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.535,0.0002,-0.0239,Neutral,0.0,Neutral,7e-05,-0.09256,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.5178,0.0001,-22.2066,-4.03339101020224,0.6039329838060254,Uncertain,0.9364,pathogenic,-3.964,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135V,NP_000537:p.Cys135Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.25823,-0.6120619773864746,0.28673,-0.4614867682104723,-0.48575,-0.8598583841052361,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.535,-0.0001,,,0.0,Neutral,0.0,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.5143,0.0001,-22.2066,-2.75741532825132,0.5160001157723466,Uncertain,0.8707,pathogenic,-3.803,available,https://doi.org/10.1101/2022.10.22.513328 +C135W,NP_000537:p.Cys135Trp,"hg19,17:g.7578525G>C, hg19,17:g.7675207G>C, hg38,17:g.7675207G>C",,,0.884,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376561,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,27.57794,1.2739468812942505,4.36293,2.242524037972694,15.970435000000002,14.910232018986347,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.535,0.00778,0.06307,Neutral,0.00532,Neutral,0.00848,-0.00635,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.4894,0.0001,-22.2066,-7.76909942258231,0.8438731335427598,Pathogenic,0.9986,pathogenic,-4.58,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C135Y,NP_000537:p.Cys135Tyr,"hg19,17:g.7578526C>T, hg19,17:g.7675208C>T, hg38,17:g.7675208C>T",,0.0,0.955,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141762,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.64326,1.3517946004867554,4.05544,1.635467816342155,7.349349999999999,6.139363908171077,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.535,0.01544,-0.07736,Neutral,0.01518,Neutral,0.00877,-0.0281,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.18,E,-0.4956,0.0001,-22.2066,-7.76909942258231,0.8558744238904845,Pathogenic,0.998,pathogenic,-4.432,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136A,NP_000537:p.Gln136Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.05967,0.6835579872131348,1.20034,0.470125728704448,0.6300049999999999,0.264897864352224,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.32,0.11226,,Uncertain,-0.01075,Neutral,0.24552,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.01,-,-0.2921,0.0831,-22.2066,-6.07479924986444,0.8189513046682451,Pathogenic,0.7569,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328 +Q136C,NP_000537:p.Gln136Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.17803,0.7353979349136353,0.90204,0.9865147053917576,0.36200499999999997,0.40424235269587877,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.32,0.15306,,Uncertain,-0.00045,Neutral,-0.01095,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.01,-,-0.3383,0.0831,-22.2066,-6.11443374786994,0.8468264934742922,Pathogenic,0.9825,pathogenic,-4.468,available,https://doi.org/10.1101/2022.10.22.513328 +Q136D,NP_000537:p.Gln136Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2709,2.2502870559692383,1.40748,1.1928582202892717,0.5682900000000001,0.4609791101446359,Neutral,Neutral,Destabilizing,Neutral,Neutral,True,0.32,0.71084,,Uncertain,-0.12842,Neutral,0.2794,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.01,-,-0.3786,0.0831,-22.2066,-3.53119377224444,0.5621465368322383,Uncertain,0.9794,pathogenic,-4.234,available,https://doi.org/10.1101/2022.10.22.513328 +Q136E,NP_000537:p.Gln136Glu,"hg19,17:g.7578524G>C, hg19,17:g.7675206G>C, hg38,17:g.7675206G>C",,,0.862,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480751,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22011,1.1053969860076904,1.63741,0.5756454663900279,0.92876,0.39787773319501396,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.32,0.57468,-0.06792,Neutral,-0.09953,Neutral,0.36029,0.07462,Neutral,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.01,-,-0.2972,0.0831,-22.2066,-3.96356314997428,0.6556975998327883,Uncertain,0.7507,pathogenic,-4.201,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136F,NP_000537:p.Gln136Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.1,1.0579732656478882,1.6466,-0.2874439018438546,0.7733,-0.1937219509219273,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.32,0.2274,,Uncertain,0.20519,Neutral,0.13664,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.01,-,-0.3463,0.0831,-22.2066,-6.79269182513879,0.8700496026826428,Pathogenic,0.9884,pathogenic,-4.582,available,https://doi.org/10.1101/2022.10.22.513328 +Q136G,NP_000537:p.Gln136Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.78483,1.1946077346801758,1.71633,1.6922243416561518,1.25058,1.2385271708280758,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.32,0.10442,,Uncertain,-0.01351,Neutral,0.24166,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.01,-,-0.3627,0.0831,-22.2066,-6.03279846291544,0.7237408510483924,Pathogenic,0.8554,pathogenic,-4.364,available,https://doi.org/10.1101/2022.10.22.513328 +Q136H,NP_000537:p.Gln136His,"hg19,17:g.7578522T>A, hg19,17:g.7578522T>G, hg19,17:g.7675204T>A, hg38,17:g.7675204T>A, hg38,17:g.7675204T>G",,,0.946,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","482213, 186301","Uncertain significance, Uncertain significance","2, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.66452,1.0637892484664917,1.34252,0.2161036061141219,1.00352,0.44031180305706097,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.32,-0.01908,0.04651,Neutral,-0.00901,Neutral,0.28101,0.01956,Neutral,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.01,-,-0.2931,0.0831,-22.2066,-5.9678328038887,0.8278741802972036,Pathogenic,0.9347,pathogenic,-4.061,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136I,NP_000537:p.Gln136Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01884,0.9845637083053588,1.63537,-0.2537054246368225,0.808265,-0.13627271231841126,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.32,0.16932,,Uncertain,0.01629,Neutral,0.23948,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.01,-,-0.3277,0.0831,-22.2066,-5.98894516201986,0.7336346054825247,Pathogenic,0.9617,pathogenic,-4.469,available,https://doi.org/10.1101/2022.10.22.513328 +Q136K,NP_000537:p.Gln136Lys,"hg38,17:g.7675206G>T",,,0.869,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.74497,0.4466183185577392,1.32721,0.4257648358614224,0.29112,-0.15960258206928882,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.32,-0.23288,0.16519,Neutral,0.07665,Neutral,-0.05681,0.05408,Neutral,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.01,-,-0.3252,0.0831,-22.2066,-4.52687386162523,0.1155611862640654,Benign,0.7678,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136L,NP_000537:p.Gln136Leu,"hg19,17:g.7578523T>A, hg38,17:g.7675205T>A",,,0.959,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3906024,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.05484,1.1453535556793213,1.27313,-0.4625175170899676,0.10914500000000005,-0.7586787585449838,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.32,0.22782,0.03033,Neutral,0.03749,Neutral,0.24352,0.02482,Neutral,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.01,-,-0.311,0.0831,-22.2066,-4.75013824650229,0.6105873545019772,Uncertain,0.7798,pathogenic,-4.147,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136M,NP_000537:p.Gln136Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.05533,0.3905736207962036,0.7619,0.0819329874222596,-0.14671500000000004,-0.48669850628887024,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.32,0.16768,,Uncertain,0.0086,Neutral,0.25476,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.01,-,-0.282,0.0831,-22.2066,-5.98654735740999,0.6586092103503343,Uncertain,0.8546,pathogenic,-4.242,available,https://doi.org/10.1101/2022.10.22.513328 +Q136N,NP_000537:p.Gln136Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.19912,1.573005199432373,0.8017,0.8505278103043159,0.50041,0.5248239051521579,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.32,-0.10548,,Uncertain,-0.00538,Neutral,0.2212,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.01,-,-0.3077,0.0831,-22.2066,-3.5328148857172,0.0786184914553901,Benign,0.8454,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328 +Q136P,NP_000537:p.Gln136Pro,"hg19,17:g.7578523T>G, hg19,17:g.7675205T>G, hg38,17:g.7675205T>G",,,0.964,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",580807,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.13435,2.370743751525879,6.42551,4.419835994777968,5.27993,4.277092997388984,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.32,0.12984,0.03081,Neutral,-0.01152,Neutral,0.22706,-0.04386,Neutral,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.01,-,-0.4657,0.0831,-22.2066,-7.55484873899529,0.8667725459074227,Pathogenic,0.9437,pathogenic,-4.435,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136R,NP_000537:p.Gln136Arg,"hg38,17:g.7675205T>C",,,0.877,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.40162,0.5606625080108643,0.46565,0.0184940161526259,0.032015000000000016,-0.19156299192368703,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.32,-0.42498,0.08188,Neutral,0.1764,Neutral,-0.02822,0.10079,Neutral,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.01,-,-0.2441,0.0831,-6.5969,-3.00005215368022,0.0048621775462786,Benign,0.6506,pathogenic,-3.742,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q136S,NP_000537:p.Gln136Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.54888,0.8947767019271851,1.51769,1.0471649419726654,1.033285,0.7980224709863327,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.32,0.13848,,Uncertain,-0.0102,Neutral,0.2327,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.01,-,-0.3105,0.0831,-22.2066,-5.91381299408609,0.6830269456205689,Pathogenic,0.707,pathogenic,-4.175,available,https://doi.org/10.1101/2022.10.22.513328 +Q136T,NP_000537:p.Gln136Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.81477,1.0623292922973633,1.19456,0.5959484791861613,1.5046650000000001,1.2053592395930806,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.32,0.15726,,Uncertain,-0.00218,Neutral,0.23769,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.01,-,-0.3204,0.0831,-22.2066,-6.13762588658129,0.7240386421979033,Pathogenic,0.8488,pathogenic,-4.241,available,https://doi.org/10.1101/2022.10.22.513328 +Q136V,NP_000537:p.Gln136Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01086,1.0065501928329468,1.58027,-0.1184901051559322,0.784705,-0.0646750525779661,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.32,0.16674,,Uncertain,0.02445,Neutral,0.23456,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.01,-,-0.3277,0.0831,-22.2066,-6.53863952051996,0.711644119295423,Pathogenic,0.9014,pathogenic,-4.294,available,https://doi.org/10.1101/2022.10.22.513328 +Q136W,NP_000537:p.Gln136Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.50255,1.6602613925933838,1.83776,-0.773261881444538,1.670155,0.364644059277731,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.32,0.28862,,Uncertain,0.38508,Neutral,0.16,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.01,-,-0.3457,0.0831,-22.2066,-6.79269182513879,0.8665211210310053,Pathogenic,0.99,pathogenic,-4.706,available,https://doi.org/10.1101/2022.10.22.513328 +Q136Y,NP_000537:p.Gln136Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14001,1.574323058128357,1.27551,-0.2351072281591287,0.70776,-0.04754861407956436,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.32,0.35114,,Uncertain,0.29355,Neutral,-0.25945,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.01,-,-0.3486,0.0831,-22.2066,-6.79269182513879,0.870762336145894,Pathogenic,0.9841,pathogenic,-4.638,available,https://doi.org/10.1101/2022.10.22.513328 +L137A,NP_000537:p.Leu137Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.28225,1.6999746561050415,1.24014,2.547542184195969,1.2611949999999998,1.9148960920979845,Neutral,Uncertain,Uncertain,Neutral,Neutral,True,0.36,0.00334,,Uncertain,-0.1956,Neutral,0.17167,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.3129,1.1568,-22.2066,-6.08868894034508,0.6763957743026042,Uncertain,0.9163,pathogenic,-3.908,available,https://doi.org/10.1101/2022.10.22.513328 +L137C,NP_000537:p.Leu137Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.68099,0.9138702750205994,1.30408,3.0876128924645063,1.492535,2.384301446232253,Neutral,Uncertain,Neutral,Neutral,Uncertain,True,0.36,0.04884,,Uncertain,-0.02124,Neutral,0.09654,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.3021,1.1568,-22.2066,-6.08868894034508,0.8379447255653671,Pathogenic,0.979,pathogenic,-4.275,available,https://doi.org/10.1101/2022.10.22.513328 +L137D,NP_000537:p.Leu137Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.72802,2.349280595779419,1.31837,3.3730851938814723,1.5231949999999999,2.550552596940736,Neutral,Uncertain,Destabilizing,Neutral,Uncertain,True,0.36,0.47142,,Uncertain,-0.0768,Neutral,0.54111,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.4344,1.1568,-22.2066,-6.5824339581492,0.8383206820472677,Pathogenic,0.9968,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328 +L137E,NP_000537:p.Leu137Glu,"hg19,17:g.7578520_7578521delinsTC, hg38,17:g.7675202_7675203delinsTC",,,,"ClinVar,saturation_mutlist",1713937,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.83802,1.7915431261062622,-6.44524,2.7615838765634853,-2.80361,1.7998019382817425,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.36,0.49008,0.07317,Neutral,-0.0674,Neutral,0.06217,0.01463,Neutral,36.0,,False,36.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.4025,1.1568,-22.2066,-6.5824339581492,0.8366984703838687,Pathogenic,0.98,pathogenic,-4.338,available,https://doi.org/10.1101/2022.10.22.513328 +L137F,NP_000537:p.Leu137Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.20051,0.6815310716629028,-0.03503,0.7843746580575278,0.08274,0.4924423290287639,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.36,0.00404,,Uncertain,0.13202,Neutral,0.14151,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.2464,1.1568,-22.2066,-5.69912924308325,0.5603845899864934,Uncertain,0.9135,pathogenic,-3.865,available,https://doi.org/10.1101/2022.10.22.513328 +L137G,NP_000537:p.Leu137Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.15771,2.667576313018799,2.43435,3.891445224429179,2.29603,3.024577612214589,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,True,0.36,-0.01486,,Uncertain,-0.02389,Neutral,-0.04376,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.3877,1.1568,-22.2066,-6.95235868798953,0.8620186302619599,Pathogenic,0.9819,pathogenic,-4.32,available,https://doi.org/10.1101/2022.10.22.513328 +L137H,NP_000537:p.Leu137His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.70474,1.4516521692276,1.27551,1.8984581525088464,1.490125,1.8015990762544232,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.36,0.08476,,Uncertain,0.14119,Neutral,0.03769,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.3553,1.1568,-22.2066,-6.41042875411472,0.8140609161149494,Pathogenic,0.976,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328 +L137I,NP_000537:p.Leu137Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.54188,0.2576262950897217,0.51871,1.0289807489886764,0.530295,0.7854303744943383,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.36,0.0548,,Uncertain,0.02699,Neutral,0.03108,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.93,T,-0.0776,1.1568,-0.7691,-2.4694550821995,0.0027929738397298,Benign,0.3715,ambiguous,-3.183,available,https://doi.org/10.1101/2022.10.22.513328 +L137K,NP_000537:p.Leu137Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.71284,1.343275547027588,1.17381,2.7335289232263293,0.943325,1.7231844616131646,Neutral,Uncertain,Uncertain,Neutral,Neutral,True,0.36,-0.10456,,Uncertain,0.6092,Neutral,0.03005,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.93,T,-0.4015,1.1568,-22.2066,-4.75205378698714,0.1491637743739586,Benign,0.9115,pathogenic,-3.879,available,https://doi.org/10.1101/2022.10.22.513328 +L137M,NP_000537:p.Leu137Met,"hg38,17:g.7675203G>T",,,0.637,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.50434,0.7802917957305908,0.73265,1.3649760084486835,0.618495,0.9346580042243418,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.36,0.03482,-0.10643,Neutral,-0.01775,Neutral,0.08785,-0.00701,Neutral,36.0,,False,36.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.93,T,-0.1248,1.1568,-5.4594,-0.737629429540157,0.000587075262993,Benign,0.3219,benign,-3.086,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L137N,NP_000537:p.Leu137Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.81176,2.0487897396087646,1.87313,2.780917141024269,1.842445,2.2963385705121344,Neutral,Uncertain,Destabilizing,Neutral,Uncertain,True,0.36,0.08596,,Uncertain,-0.01457,Neutral,0.09373,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.3807,1.1568,-22.2066,-6.5824339581492,0.7633185476228058,Pathogenic,0.9693,pathogenic,-4.111,available,https://doi.org/10.1101/2022.10.22.513328 +L137P,NP_000537:p.Leu137Pro,"hg38,17:g.7675202A>G",,,0.950,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.14893,1.3997076749801636,-0.40816,4.063805023209041,-0.778545,1.4574375116045206,Neutral,Uncertain,Uncertain,Neutral,Neutral,True,0.36,0.12628,-0.1439,Neutral,0.06092,Neutral,0.06468,0.23729,Neutral,36.0,,False,36.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.3963,1.1568,-22.2066,-4.98533951832152,0.2161250945982092,Benign,0.9377,pathogenic,-3.846,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L137Q,NP_000537:p.Leu137Gln,"hg19,17:g.7578520A>T, hg19,17:g.7675202A>T, hg38,17:g.7675202A>T",,,0.951,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3972459,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.04974,1.6444774866104126,0.09082,2.478896124015224,0.5702799999999999,1.764318062007612,Neutral,Uncertain,Uncertain,Neutral,Neutral,True,0.36,0.15844,-0.28952,Neutral,-0.00922,Neutral,0.14591,0.13799,Neutral,36.0,,False,36.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.3337,1.1568,-22.2066,-6.23359532734253,0.6209150571251112,Uncertain,0.9075,pathogenic,-3.998,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L137R,NP_000537:p.Leu137Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.7767,1.4022302627563477,1.25986,2.144744405778647,1.0182799999999999,1.4607222028893234,Neutral,Uncertain,Uncertain,Neutral,Neutral,True,0.36,-0.97258,,Uncertain,0.361,Neutral,-0.05131,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.3253,1.1568,-8.9187,-3.7612614386269,0.1280623138918843,Benign,0.8728,pathogenic,-3.804,available,https://doi.org/10.1101/2022.10.22.513328 +L137S,NP_000537:p.Leu137Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.34333,2.034529447555542,2.02245,3.4006804752396578,1.68289,2.372005237619829,Uncertain,Uncertain,Destabilizing,Neutral,Uncertain,True,0.36,0.07592,,Uncertain,-0.02505,Neutral,0.20705,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.3433,1.1568,-22.2066,-4.4456022084144,0.0010824790992534,Benign,0.9802,pathogenic,-3.793,available,https://doi.org/10.1101/2022.10.22.513328 +L137T,NP_000537:p.Leu137Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.87781,1.6618266105651855,0.85544,2.6981655167045093,0.866625,1.7879877583522545,Neutral,Uncertain,Uncertain,Neutral,Neutral,True,0.36,0.0934,,Uncertain,0.00713,Neutral,0.03163,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.316,1.1568,-22.2066,-6.08868894034508,0.6179440960651175,Uncertain,0.9389,pathogenic,-3.812,available,https://doi.org/10.1101/2022.10.22.513328 +L137V,NP_000537:p.Leu137Val,"hg19,17:g.7578521G>C, hg38,17:g.7675203G>C",,,0.731,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1005829,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.63022,0.6672430038452148,-0.41905,1.5711620943793454,0.605585,1.6006910471896727,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.36,0.00268,0.20299,Neutral,-0.01807,Neutral,0.06417,0.24343,Neutral,36.0,,False,36.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.1504,1.1568,-7.9188,-2.4585383477174,0.0663916497189654,Benign,0.4695,ambiguous,-3.407,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L137W,NP_000537:p.Leu137Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.00359,0.8256086111068726,-0.18707,0.78520946020671,0.40826,0.894399730103355,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.36,0.02438,,Uncertain,0.0768,Neutral,-0.03876,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.3455,1.1568,-22.2066,-6.41042875411472,0.7669160714452511,Pathogenic,0.9609,pathogenic,-4.279,available,https://doi.org/10.1101/2022.10.22.513328 +L137Y,NP_000537:p.Leu137Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.64696,0.8411794900894165,0.32177,1.1810377671198236,-0.162595,0.2670388835599118,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.36,0.00446,,Uncertain,0.1589,Neutral,0.09549,,Uncertain,36.0,,False,36.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.93,T,-0.3384,1.1568,-22.2066,-6.41042875411472,0.8588307601369856,Pathogenic,0.972,pathogenic,-4.289,available,https://doi.org/10.1101/2022.10.22.513328 +A138C,NP_000537:p.Ala138Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15907,-0.5137479305267334,-0.06565,1.083647941566953,-0.11235999999999999,0.4622889707834765,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,0.00916,,Uncertain,,Uncertain,-8e-05,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.2521,0.2233,-8.9187,-2.60075011127951,0.566053613177317,Uncertain,0.8354,pathogenic,-4.164,available,https://doi.org/10.1101/2022.10.22.513328 +A138D,NP_000537:p.Ala138Asp,"hg19,17:g.7578517G>T, hg38,17:g.7675199G>T",,,0.901,"COSMIC,ClinVar,saturation_mutlist",528270,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.32154,0.0728796124458313,0.21633,0.7559736671299035,0.268935,0.5387568335649517,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,0.21236,0.02132,Neutral,,Uncertain,0.06139,0.05757,Neutral,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.4016,0.2233,-22.2066,-3.70793948350202,0.0426949165859065,Benign,0.9364,pathogenic,-3.904,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A138E,NP_000537:p.Ala138Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.40556,0.2269477844238281,0.64252,0.7208570909760303,0.11848,0.15764854548801518,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,0.22164,,Uncertain,,Uncertain,0.07487,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.3143,0.2233,-7.9188,-4.02504115372283,0.0200507974556553,Benign,0.884,pathogenic,-3.841,available,https://doi.org/10.1101/2022.10.22.513328 +A138F,NP_000537:p.Ala138Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.58276,-0.1120185256004333,-0.15204,-0.1048501063653511,0.21535999999999997,0.23895494681732443,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,0.0147,,Uncertain,,Uncertain,5e-05,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.37,0.2233,-22.2066,-7.05804875358714,0.56145932795437,Uncertain,0.8895,pathogenic,-4.346,available,https://doi.org/10.1101/2022.10.22.513328 +A138G,NP_000537:p.Ala138Gly,"hg19,17:g.7578517G>C, hg38,17:g.7675199G>C",,,0.842,"ClinVar,saturation_mutlist",1375764,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.1969,-0.6104704141616821,-0.16361,1.054603384145372,-0.680255,-0.07114830792731408,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,-0.0103,-0.07072,Neutral,,Uncertain,-6e-05,0.02034,Neutral,44.4,,True,44.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.45,T,-0.2313,0.2233,-6.1115,-2.94024134866916,0.000251354592281,Benign,0.2073,benign,-3.394,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A138H,NP_000537:p.Ala138His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.59894,-0.2010940909385681,-0.57177,0.151694709996733,0.513585,0.8753173549983665,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,0.02266,,Uncertain,,Uncertain,0.00045,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.3741,0.2233,-22.2066,-6.63106118000632,0.7381829367000703,Pathogenic,0.9196,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +A138I,NP_000537:p.Ala138Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.3803,0.8596250414848328,4.07245,0.3610175787220759,2.226375,0.37065878936103797,Uncertain,Neutral,Neutral,Uncertain,Neutral,True,0.292,0.0145,,Uncertain,,Uncertain,0.00416,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.3595,0.2233,-22.2066,-6.7213668870673,0.8166396584826955,Pathogenic,0.9865,pathogenic,-4.304,available,https://doi.org/10.1101/2022.10.22.513328 +A138K,NP_000537:p.Ala138Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.97388,0.0020475387573242,-1.16122,0.2521210381629052,-1.06755,-0.3608794809185474,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,-0.1266,,Uncertain,,Uncertain,-0.04217,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.3919,0.2233,-22.2066,-5.44367088275368,0.5010461180494552,Uncertain,0.9621,pathogenic,-4.053,available,https://doi.org/10.1101/2022.10.22.513328 +A138L,NP_000537:p.Ala138Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.94807,-0.0403025150299072,0.08673,-0.0361955402135422,-0.43067,-0.4921327701067711,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,0.02424,,Uncertain,,Uncertain,8e-05,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.3643,0.2233,-22.2066,-5.65679517439494,0.6878357773190119,Pathogenic,0.8123,pathogenic,-4.112,available,https://doi.org/10.1101/2022.10.22.513328 +A138M,NP_000537:p.Ala138Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.56533,-0.218283474445343,-0.02959,0.1819143065286677,-0.7974600000000001,-0.6917078467356662,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,-0.02616,,Uncertain,,Uncertain,0.00462,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.323,0.2233,-22.2066,-6.55434917449774,0.5460669597772883,Uncertain,0.8812,pathogenic,-4.117,available,https://doi.org/10.1101/2022.10.22.513328 +A138N,NP_000537:p.Ala138Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.30643,-0.3740930557250976,-0.75986,0.2392492346409891,-0.533145,-0.03359038267950544,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,0.00626,,Uncertain,,Uncertain,-1e-05,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.372,0.2233,-22.2066,-4.71219397097115,0.0469210581647958,Benign,0.7196,pathogenic,-3.809,available,https://doi.org/10.1101/2022.10.22.513328 +A138P,NP_000537:p.Ala138Pro,"hg19,17:g.7578518C>G, hg19,17:g.7675200C>G, hg38,17:g.7675200C>G",,,0.949,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12376,Likely pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.45609,1.1836377382278442,7.73469,4.627770171221917,6.59539,5.041930085610958,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.292,0.13278,0.0941,Neutral,,Uncertain,-0.05842,0.14942,Neutral,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.4413,0.2233,-22.2066,-7.56742875363704,0.7961553770657813,Pathogenic,0.9887,pathogenic,-4.297,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A138Q,NP_000537:p.Ala138Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.84023,-0.0067687630653381,-0.26939,0.5965699724455716,-0.55481,-0.1218300137772142,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,0.01996,,Uncertain,,Uncertain,0.00223,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.3695,0.2233,-22.2066,-5.09655753060162,0.6119058083787835,Uncertain,0.7173,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328 +A138R,NP_000537:p.Ala138Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.3825,0.05812269449234,-0.08197,0.0158995810012174,-0.232235,-0.1833002094993913,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,-0.283,,Uncertain,,Uncertain,-0.09313,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.4026,0.2233,-22.2066,-5.46389254293497,0.6214621882296107,Uncertain,0.8602,pathogenic,-4.152,available,https://doi.org/10.1101/2022.10.22.513328 +A138S,NP_000537:p.Ala138Ser,"hg38,17:g.7675200C>A",,,0.911,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.30959,0.1879197657108307,0.27245,0.8717111261708851,-0.018569999999999975,0.2810605630854426,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,-0.0387,0.04036,Neutral,,Uncertain,-0.02317,0.03062,Neutral,44.4,,True,44.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.45,T,-0.2087,0.2233,-7.3339,-2.23612043909446,0.0073701632163356,Benign,0.174,benign,-3.44,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A138T,NP_000537:p.Ala138Thr,"hg19,17:g.7578518C>T, hg19,17:g.7675200C>T, hg38,17:g.7675200C>T",,,0.910,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1053218,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.46513,0.6953195333480835,0.32279,0.8360547712690675,-0.07116999999999998,0.18546238563453374,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,0.00686,0.05863,Neutral,,Uncertain,0.00066,-0.00908,Neutral,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.2905,0.2233,-22.2066,-4.55908750981123,0.6577305988634715,Uncertain,0.7817,pathogenic,-3.829,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A138V,NP_000537:p.Ala138Val,"hg19,17:g.7578517G>A, hg19,17:g.7675199G>A, hg38,17:g.7675198_7675199delinsAA, hg38,17:g.7675199G>A",,0.0,0.870,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",184863,Likely pathogenic,3,Likely oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.47333,0.7599952816963196,3.83367,0.4386978617868081,2.1535,0.45601393089340403,Uncertain,Neutral,Neutral,Uncertain,Neutral,True,0.292,0.00486,-0.24522,Neutral,,Uncertain,-0.00913,-0.06823,Neutral,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.2876,0.2233,-22.2066,-6.7213668870673,0.5095397216163231,Uncertain,0.9331,pathogenic,-4.076,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A138W,NP_000537:p.Ala138Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.29366,0.1858538091182708,0.14524,-0.1333320913357916,0.71945,0.5801639543321042,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,0.01332,,Uncertain,,Uncertain,0.00256,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.3809,0.2233,-22.2066,-7.05804875358714,0.8377557119604753,Pathogenic,0.9817,pathogenic,-4.63,available,https://doi.org/10.1101/2022.10.22.513328 +A138Y,NP_000537:p.Ala138Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.71295,0.0748491883277893,-0.05986,0.0900243952013662,0.326545,0.4014871976006831,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.292,0.01352,,Uncertain,,Uncertain,6e-05,,Uncertain,44.4,,True,44.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.45,T,-0.3892,0.2233,-22.2066,-7.05804875358714,0.7813545020179077,Pathogenic,0.9298,pathogenic,-4.496,available,https://doi.org/10.1101/2022.10.22.513328 +K139A,NP_000537:p.Lys139Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30295,-0.4184869527816772,-0.86122,0.4992653070675995,-0.279135,0.40110765353379974,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3153,0.0758,-22.2066,-4.75847962272788,0.5241155240132733,Uncertain,0.9585,pathogenic,-3.97,available,https://doi.org/10.1101/2022.10.22.513328 +K139C,NP_000537:p.Lys139Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.69194,-0.1872565746307373,-0.26293,0.8976773519624855,0.214505,0.7948086759812427,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3855,0.0758,-22.2066,-4.83709909651191,0.6378070224822506,Uncertain,0.9748,pathogenic,-4.162,available,https://doi.org/10.1101/2022.10.22.513328 +K139D,NP_000537:p.Lys139Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.71797,1.491423726081848,0.26497,0.9357673430146192,0.99147,1.3268686715073095,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.4243,0.0758,-22.2066,-6.36344461990687,0.7970832941255395,Pathogenic,0.994,pathogenic,-4.438,available,https://doi.org/10.1101/2022.10.22.513328 +K139E,NP_000537:p.Lys139Glu,"hg19,17:g.7578515T>C, hg19,17:g.7675197T>C, hg38,17:g.7675197T>C",,,0.844,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",658923,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.31594,0.3769617676734924,-0.31293,0.6393626314760888,0.0015050000000000063,0.4776513157380444,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3402,0.0758,-22.2066,-5.50675267393172,0.5092324730407694,Uncertain,0.9567,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K139F,NP_000537:p.Lys139Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.26158,0.3280569911003113,-0.22211,0.0122964886411963,0.01973499999999999,0.13693824432059815,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3865,0.0758,-22.2066,-7.26153898005645,0.8214464931494126,Pathogenic,0.9972,pathogenic,-4.624,available,https://doi.org/10.1101/2022.10.22.513328 +K139G,NP_000537:p.Lys139Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.52288,0.8233880996704102,0.96871,1.2914987972951038,1.245795,1.4071893986475519,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3745,0.0758,-22.2066,-7.78578005565755,0.8701728717577566,Pathogenic,0.9722,pathogenic,-4.348,available,https://doi.org/10.1101/2022.10.22.513328 +K139H,NP_000537:p.Lys139His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48796,0.4511011838912964,-1.03197,0.1103730613217207,-0.27200500000000005,0.29916653066086035,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3254,0.0758,-22.2066,-7.06339340036591,0.6453513576526843,Uncertain,0.8916,pathogenic,-4.034,available,https://doi.org/10.1101/2022.10.22.513328 +K139I,NP_000537:p.Lys139Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.4546,0.2653933763504028,-0.34728,0.1118032355486114,0.05366000000000001,0.2832016177743057,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.64,-,-0.3537,0.0758,-22.2066,-6.21901222752533,0.8396300425404963,Pathogenic,0.9804,pathogenic,-4.295,available,https://doi.org/10.1101/2022.10.22.513328 +K139L,NP_000537:p.Lys139Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.25258,0.2059521675109863,0.26667,-0.1446460693255313,0.007044999999999996,-0.19861303466276567,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.64,-,-0.3524,0.0758,-22.2066,-4.88349226758231,0.7338494748605879,Pathogenic,0.965,pathogenic,-4.17,available,https://doi.org/10.1101/2022.10.22.513328 +K139M,NP_000537:p.Lys139Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.09891,-0.1062451601028442,-0.25748,0.2656289459841165,-0.178195,0.08335947299205826,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3254,0.0758,-22.2066,-5.51070077052122,0.8377482907472718,Pathogenic,0.9403,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +K139N,NP_000537:p.Lys139Asn,"hg19,17:g.7578513C>A, hg19,17:g.7578513C>G, hg19,17:g.7675195C>A, hg19,17:g.7675195C>G, hg38,17:g.7675195C>A, hg38,17:g.7675195C>G",,,0.730,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",584923,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.82237,0.9644744396209716,0.37381,0.5538918004787219,0.59809,0.688130900239361,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3336,0.0758,-22.2066,-5.9949319493192,0.557200039113269,Uncertain,0.9818,pathogenic,-3.98,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K139P,NP_000537:p.Lys139Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.95234,2.447789669036865,4.87007,3.3934071430559376,4.411205,3.672873571527969,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.4897,0.0758,-22.2066,-7.78578005565755,0.865919751916198,Pathogenic,0.992,pathogenic,-4.37,available,https://doi.org/10.1101/2022.10.22.513328 +K139Q,NP_000537:p.Lys139Gln,"hg19,17:g.7578515T>G, hg38,17:g.7675197T>G",,,0.768,"COSMIC,ClinVar,saturation_mutlist",1692473,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30993,-0.1604801416397094,-0.50374,0.5341189937179666,-0.09690499999999999,0.42202449685898324,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.2468,0.0758,-8.9187,-3.759511359164,0.5850505375617158,Uncertain,0.772,pathogenic,-3.788,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K139R,NP_000537:p.Lys139Arg,"hg19,17:g.7578514T>C, hg38,17:g.7675196T>C",,,0.760,"COSMIC,ClinVar,saturation_mutlist",1500748,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.04737,0.1873330473899841,-0.77109,0.0200389356248054,-0.40923000000000004,-0.013665532187597302,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.64,-,-0.1731,0.0758,-7.3339,-2.05403664958797,0.0105463550704981,Benign,0.174,benign,-3.478,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K139S,NP_000537:p.Lys139Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.77106,0.1163765788078308,0.41701,0.8082175431152108,0.594035,0.7896387715576054,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3255,0.0758,-22.2066,-4.78891889475202,0.5331461738099135,Uncertain,0.9706,pathogenic,-3.887,available,https://doi.org/10.1101/2022.10.22.513328 +K139T,NP_000537:p.Lys139Thr,"hg19,17:g.7578514T>G, hg19,17:g.7675196T>G, hg38,17:g.7675196T>G",,,0.800,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1338658,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.69728,0.3985752463340759,-0.0449,0.5390691586897828,0.32619,0.6181745793448914,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3373,0.0758,-22.2066,-4.58963231057883,0.4002054800686839,Uncertain,0.8955,pathogenic,-3.867,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K139V,NP_000537:p.Lys139Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.61931,0.2165665626525879,-0.80884,0.0247277129881062,-0.09476499999999999,0.3220188564940531,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3376,0.0758,-22.2066,-5.00452799386083,0.2136197625434333,Benign,0.9295,pathogenic,-3.989,available,https://doi.org/10.1101/2022.10.22.513328 +K139W,NP_000537:p.Lys139Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.90188,0.5200446248054504,0.01156,-0.4019654128846101,0.45672,0.24995729355769497,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3955,0.0758,-22.2066,-7.26153898005645,0.8683746910360057,Pathogenic,0.9951,pathogenic,-4.611,available,https://doi.org/10.1101/2022.10.22.513328 +K139Y,NP_000537:p.Lys139Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30868,0.4935587644577026,-0.22415,0.0791736957506034,0.04226500000000001,0.1939268478753017,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.13,,,Uncertain,,Uncertain,,,Uncertain,57.0,,True,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,-,-0.3713,0.0758,-22.2066,-7.26153898005645,0.8688527728086746,Pathogenic,0.991,pathogenic,-4.488,available,https://doi.org/10.1101/2022.10.22.513328 +T140A,NP_000537:p.Thr140Ala,"hg19,17:g.7578512T>C, hg19,17:g.7675194T>C, hg38,17:g.7675194T>C",,,0.806,"cBioPortal,ClinVar,saturation_mutlist",644101,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.40265,0.3637278079986572,0.49762,0.4274114773743992,0.950135,0.9150307386871996,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.02,-,-0.2282,0.2014,-7.3339,-1.68949918052894,0.0006866635869329,Benign,0.559,ambiguous,-3.436,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T140C,NP_000537:p.Thr140Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.52866,0.0514898896217346,0.38163,1.014010581399361,0.9551449999999999,1.2713352906996804,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.02,-,-0.3399,0.2014,-22.2066,-4.43103998340895,0.7276086680460926,Pathogenic,0.9361,pathogenic,-4.134,available,https://doi.org/10.1101/2022.10.22.513328 +T140D,NP_000537:p.Thr140Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.00731,1.0608255863189695,0.76361,0.4068650248134736,1.38546,1.2070875124067368,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.02,-,-0.4197,0.2014,-22.2066,-6.00987719184112,0.7182427126081831,Pathogenic,0.9686,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +T140E,NP_000537:p.Thr140Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.30988,0.9328446984291076,-0.3415,0.1593752950909199,0.48418999999999995,0.73462764754546,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.02,-,-0.395,0.2014,-22.2066,-6.30908586921817,0.8281102379953241,Pathogenic,0.9721,pathogenic,-4.252,available,https://doi.org/10.1101/2022.10.22.513328 +T140F,NP_000537:p.Thr140Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.09072,0.5095402002334595,1.95714,-0.4343666535503232,1.52393,0.32817667322483834,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.02,-,-0.4113,0.2014,-22.2066,-5.14317644782034,0.67069179225716,Uncertain,0.9683,pathogenic,-4.037,available,https://doi.org/10.1101/2022.10.22.513328 +T140G,NP_000537:p.Thr140Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.41972,0.8143793344497681,1.90612,1.5409250298232484,2.1629199999999997,1.9803225149116241,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.02,-,-0.3776,0.2014,-22.2066,-7.36060391745808,0.8338484958366235,Pathogenic,0.8458,pathogenic,-4.214,available,https://doi.org/10.1101/2022.10.22.513328 +T140H,NP_000537:p.Thr140His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.74336,0.3761888742446899,0.85918,-0.0149738432202617,1.3012700000000001,0.8641930783898691,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.02,-,-0.3916,0.2014,-22.2066,-5.97812061244266,0.6439222219216326,Uncertain,0.9387,pathogenic,-4.139,available,https://doi.org/10.1101/2022.10.22.513328 +T140I,NP_000537:p.Thr140Ile,"hg19,17:g.7578511G>A, hg38,17:g.7675192_7675193delinsAA, hg38,17:g.7675193G>A",,,0.842,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.01066,-0.3883216381072998,-0.42857,-0.7347657202798713,0.29104499999999994,0.1379471398600643,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.02,-,-0.33,0.2014,-22.2066,-4.78355061393865,0.1737498927935706,Benign,0.9262,pathogenic,-3.773,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T140K,NP_000537:p.Thr140Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.74961,-0.1598693132400512,0.44014,0.2532590681961244,0.594875,0.5014345340980622,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.02,-,-0.3872,0.2014,-22.2066,-6.13539200512126,0.3848268626183547,Uncertain,0.9451,pathogenic,-3.924,available,https://doi.org/10.1101/2022.10.22.513328 +T140L,NP_000537:p.Thr140Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.75114,0.1088826060295105,-0.25374,-0.8408724265056489,0.2487,-0.044866213252824416,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.02,-,-0.3141,0.2014,-8.9187,-4.1002935633788,0.0402969361810807,Benign,0.78,pathogenic,-3.846,available,https://doi.org/10.1101/2022.10.22.513328 +T140M,NP_000537:p.Thr140Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.27317,0.2315216064453125,-0.00374,-0.1691577215775197,0.134715,0.05200613921124016,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.02,-,-0.3489,0.2014,-22.2066,-5.818742562352,0.6694884499608523,Uncertain,0.7084,pathogenic,-3.927,available,https://doi.org/10.1101/2022.10.22.513328 +T140N,NP_000537:p.Thr140Asn,"hg19,17:g.7578511G>T, hg38,17:g.7675193G>T",,,0.783,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",185918,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.76833,0.5102235078811646,0.19864,0.1192746528015248,0.9834849999999999,0.9438023264007623,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.02,-,-0.2919,0.2014,-8.9187,-5.50005840003409,0.185744953581711,Benign,0.7784,pathogenic,-3.82,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T140P,NP_000537:p.Thr140Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.03319,-0.1461784839630127,-0.33265,0.8318661846164871,-0.18292,0.3993380923082436,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.02,-,-0.3887,0.2014,-6.5969,-3.39200897491382,0.0008809714978606,Benign,0.3055,benign,-3.489,available,https://doi.org/10.1101/2022.10.22.513328 +T140Q,NP_000537:p.Thr140Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.21991,0.4386890530586242,0.08435,0.2746686565506545,0.65213,0.7472893282753272,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.02,-,-0.3692,0.2014,-22.2066,-5.77115300528214,0.4551054152727653,Uncertain,0.9396,pathogenic,-3.875,available,https://doi.org/10.1101/2022.10.22.513328 +T140R,NP_000537:p.Thr140Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.95074,-0.092793583869934,-0.22891,-0.0826176054361488,0.360915,0.4340611972819256,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.02,-,-0.39,0.2014,-22.2066,-6.39457638814057,0.4860922417303724,Uncertain,0.9108,pathogenic,-3.938,available,https://doi.org/10.1101/2022.10.22.513328 +T140S,NP_000537:p.Thr140Ser,"hg19,17:g.7578512T>A, hg38,17:g.7675194T>A",,,0.835,"ClinVar,saturation_mutlist",1525853,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.11626,0.2558509111404419,1.29048,0.5674545796068478,1.20337,0.8418572898034239,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,neutral,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.02,-,-0.2,0.2014,-8.9187,-0.782318311586425,0.0175013996384052,Benign,0.6699,pathogenic,-3.436,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T140V,NP_000537:p.Thr140Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.01555,-0.0619558095932006,-0.1068,-0.5780264039346822,0.454375,0.21876179803265888,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.02,-,-0.3175,0.2014,-22.2066,-4.98885875201501,0.0456569944620872,Benign,0.7853,pathogenic,-3.724,available,https://doi.org/10.1101/2022.10.22.513328 +T140W,NP_000537:p.Thr140Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.23892,0.4371881186962127,1.88367,-0.7156429508305945,1.5612949999999999,0.26163852458470277,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.02,-,-0.4042,0.2014,-22.2066,-5.97812061244266,0.8240884917941717,Pathogenic,0.99,pathogenic,-4.41,available,https://doi.org/10.1101/2022.10.22.513328 +T140Y,NP_000537:p.Thr140Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.14449,0.3668476343154907,1.88878,-0.2735399986854575,1.516635,0.4354750006572713,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.131,,,Uncertain,,Uncertain,,,Uncertain,43.8,,True,43.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.02,-,-0.4128,0.2014,-22.2066,-5.18926166155829,0.717481821794647,Pathogenic,0.956,pathogenic,-4.128,available,https://doi.org/10.1101/2022.10.22.513328 +C141A,NP_000537:p.Cys141Ala,"hg38,17:g.7675189_7675191delinsCGC",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.00034,0.673162043094635,0.13912,0.6699051409777307,0.56973,0.8351225704888654,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,damaging,neutral,97.5,E,-0.4493,0.4684,-22.2096,-4.49506374661009,0.8703545760793197,Pathogenic,0.8948,pathogenic,-4.43,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C141D,NP_000537:p.Cys141Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.63855,2.0869460105896,3.0102,2.2951110707934843,2.824375,2.466830535396742,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,damaging,neutral,97.5,E,-0.5565,0.4684,-22.2096,-6.82655872471399,0.8688299035137168,Pathogenic,0.9982,pathogenic,-4.699,available,https://doi.org/10.1101/2022.10.22.513328 +C141E,NP_000537:p.Cys141Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.0227,1.7708534002304075,3.05136,2.2782619470870933,5.03703,4.650480973543547,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.5441,0.4684,-22.2096,-6.82655872471399,0.8689757481243963,Pathogenic,0.9992,pathogenic,-4.648,available,https://doi.org/10.1101/2022.10.22.513328 +C141F,NP_000537:p.Cys141Phe,"hg19,17:g.7578507_7578508delinsAA, hg19,17:g.7578508C>A, hg19,17:g.7675190C>A, hg38,17:g.7675190C>A",,,0.880,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376568,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.99424,0.188011884689331,7.87313,0.3913569695418606,9.433685,5.69279848477093,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.4432,0.4684,-22.2096,-5.3511347302336,0.6024816669374561,Uncertain,0.8882,pathogenic,-3.883,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C141G,NP_000537:p.Cys141Gly,"hg19,17:g.7578509A>C, hg19,17:g.7675191A>C, hg38,17:g.7675191A>C",,,0.859,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.0761,1.901808738708496,5.64456,2.7489176822930053,4.36033,2.9125088411465025,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,damaging,neutral,97.5,E,-0.4417,0.4684,-22.2096,-7.47567734522593,0.8680326424448317,Pathogenic,0.906,pathogenic,-4.494,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C141H,NP_000537:p.Cys141His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.96035,1.5496004819869995,2.32891,1.0391975144313297,6.14463,5.499773757215665,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.555,0.4684,-22.2096,-6.35585448522327,0.8633302157056174,Pathogenic,0.9922,pathogenic,-4.4,available,https://doi.org/10.1101/2022.10.22.513328 +C141I,NP_000537:p.Cys141Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.46111,-0.5036479234695435,2.25034,0.0064449899115676,0.8946149999999999,-0.2273325050442162,Uncertain,Neutral,Neutral,Neutral,Neutral,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.4731,0.4684,-22.2096,-5.49239420312258,0.4672364226767995,Uncertain,0.8966,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328 +C141K,NP_000537:p.Cys141Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.33231,1.9953608512878416,6.04728,2.82471292080242,5.189795,3.57851146040121,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.5447,0.4684,-22.2096,-7.47567734522593,0.8698044608588901,Pathogenic,0.9995,pathogenic,-4.652,available,https://doi.org/10.1101/2022.10.22.513328 +C141L,NP_000537:p.Cys141Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.22226,0.0143367052078247,1.56088,0.0489237711496115,2.3915699999999998,1.6355918855748057,Uncertain,Uncertain,Neutral,Uncertain,Neutral,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.5062,0.4684,-22.2096,-5.38272014387504,0.4072452385493216,Uncertain,0.9124,pathogenic,-3.872,available,https://doi.org/10.1101/2022.10.22.513328 +C141M,NP_000537:p.Cys141Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.15306,0.1041988134384155,0.42211,0.5166037007242147,0.787585,0.8348318503621073,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.4734,0.4684,-22.2096,-5.80371148438467,0.8141239622858947,Pathogenic,0.9493,pathogenic,-4.265,available,https://doi.org/10.1101/2022.10.22.513328 +C141N,NP_000537:p.Cys141Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.43281,1.8871181011199951,1.53673,0.9145279382572902,1.98477,1.673668969128645,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.4311,0.4684,-8.9217,-4.89443162511126,0.2287624892146604,Benign,0.977,pathogenic,-4.093,available,https://doi.org/10.1101/2022.10.22.513328 +C141P,NP_000537:p.Cys141Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.69525,2.008615016937256,6.74796,5.478129802552449,6.721605,6.086689901276225,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,damaging,neutral,97.5,E,-0.5676,0.4684,-22.2096,-7.47567734522593,0.8695610531756939,Pathogenic,0.9983,pathogenic,-4.56,available,https://doi.org/10.1101/2022.10.22.513328 +C141Q,NP_000537:p.Cys141Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.14477,1.558103322982788,1.9034,1.5927167174329475,4.024085,3.8687433587164737,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.5229,0.4684,-22.2096,-6.82655872471399,0.8268460487233154,Pathogenic,0.9951,pathogenic,-4.425,available,https://doi.org/10.1101/2022.10.22.513328 +C141R,NP_000537:p.Cys141Arg,"hg19,17:g.7578509A>G, hg19,17:g.7675191A>G, hg38,17:g.7675191A>G",,,0.861,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376565,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.3588,1.9492554664611816,6.74524,1.7981755158897827,7.552020000000001,5.078487757944892,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.5015,0.4684,-22.2096,-7.47567734522593,0.8708528671286377,Pathogenic,0.9943,pathogenic,-4.416,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C141S,NP_000537:p.Cys141Ser,"hg19,17:g.7578508C>G, hg19,17:g.7578509A>T, hg19,17:g.7675190C>G, hg38,17:g.7675190C>G, hg38,17:g.7675191A>T",,,"0.790, 0.813","cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.59905,1.0279498100280762,1.56701,1.5547814249819816,1.58303,1.5769157124909907,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,damaging,neutral,97.5,E,-0.3477,0.4684,-4.1145,-2.43914295419929,0.0016618166437629,Benign,0.8319,pathogenic,-3.728,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C141T,NP_000537:p.Cys141Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.00298,0.5977544784545898,0.21531,0.8007981844312514,1.109145,1.4018890922156257,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.3926,0.4684,-6.1145,-2.49849240637548,0.0681571255012605,Benign,0.8897,pathogenic,-3.966,available,https://doi.org/10.1101/2022.10.22.513328 +C141V,NP_000537:p.Cys141Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48654,-0.6205135583877563,-0.02687,-0.2919456413913568,0.22983499999999998,0.09729717930432158,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.4712,0.4684,-22.2096,-3.09081985626779,0.4041984094139376,Uncertain,0.7556,pathogenic,-3.88,available,https://doi.org/10.1101/2022.10.22.513328 +C141W,NP_000537:p.Cys141Trp,"hg19,17:g.7578507G>C, hg19,17:g.7675189G>C, hg38,17:g.7675189G>C",,,0.808,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376564,Pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,26.56516,0.7590257525444031,3.90986,1.3331278005263574,15.23751,13.949143900263177,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.4464,0.4684,-22.2096,-6.35585448522327,0.8408086220705873,Pathogenic,0.9877,pathogenic,-4.355,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C141Y,NP_000537:p.Cys141Tyr,"hg19,17:g.7578508C>T, hg19,17:g.7675190C>T, hg38,17:g.7675190C>T",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",140801,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.9355,0.7577310800552368,2.11054,1.0257867947424066,7.52302,6.980643397371203,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,True,0.2,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,damaging,neutral,97.5,E,-0.3847,0.4684,-8.9217,-2.49137110623133,0.8675460438380658,Pathogenic,0.9774,pathogenic,-4.352,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142A,NP_000537:p.Pro142Ala,"hg19,17:g.7578506G>C, hg38,17:g.7675188G>C",,,0.901,"COSMIC,ClinVar,saturation_mutlist",3809688,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.90591,1.5979526042938232,2.06803,-0.072799611848901,1.98697,0.9165551940755495,Uncertain,Neutral,Uncertain,Neutral,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.23,E,-0.3162,0.1232,-22.2096,-6.68937636218592,0.6917196255738904,Pathogenic,0.6572,pathogenic,-4.032,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142C,NP_000537:p.Pro142Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.12603,1.0927584171295166,2.38844,0.73953084890723,2.257235,1.432780424453615,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.23,E,-0.3489,0.1232,-22.2096,-7.06923434007735,0.86164411926317,Pathogenic,0.9781,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +P142D,NP_000537:p.Pro142Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.48302,2.777581691741944,1.76871,0.506886935407054,2.625865,1.9949534677035268,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.23,E,-0.3748,0.1232,-22.2096,-7.2245436950871,0.8551026739346033,Pathogenic,0.9952,pathogenic,-4.532,available,https://doi.org/10.1101/2022.10.22.513328 +P142E,NP_000537:p.Pro142Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.77616,2.0581719875335693,2.2085,0.3023158994307556,1.99233,1.0392379497153779,Uncertain,Neutral,Destabilizing,Neutral,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.23,E,-0.3586,0.1232,-22.2096,-7.2245436950871,0.8373644554961168,Pathogenic,0.9805,pathogenic,-4.448,available,https://doi.org/10.1101/2022.10.22.513328 +P142F,NP_000537:p.Pro142Phe,"hg19,17:g.7578505_7578506delinsAA, hg38,17:g.7675187_7675188delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.28928,1.6033246517181396,3.08503,-0.2779371069435171,2.687155,1.0056714465282415,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.23,E,-0.3773,0.1232,-22.2096,-7.11434995405517,0.8509624119019747,Pathogenic,0.9934,pathogenic,-4.552,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142G,NP_000537:p.Pro142Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.70153,2.331167459487915,3.48571,1.1236859853339731,3.09362,1.9126079926669866,Uncertain,Uncertain,Destabilizing,Destabilizing,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.23,E,-0.3306,0.1232,-22.2096,-7.91085924218022,0.8678062587772928,Pathogenic,0.9686,pathogenic,-4.38,available,https://doi.org/10.1101/2022.10.22.513328 +P142H,NP_000537:p.Pro142His,"hg38,17:g.7675187G>T",,,0.914,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.81228,2.098742961883545,3.55408,-0.1047843330339204,3.68318,1.8537478334830397,Destabilizing,Uncertain,Destabilizing,Destabilizing,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.23,E,-0.3549,0.1232,-22.2096,-6.89061955736869,0.0928330591734472,Benign,0.9499,pathogenic,-4.065,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142I,NP_000537:p.Pro142Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.28662,1.2939941883087158,1.62551,-0.1147705320564268,1.4560650000000002,0.5859247339717867,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.23,E,-0.3603,0.1232,-22.2096,-6.6210502474622,0.8168382547942192,Pathogenic,0.9726,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +P142K,NP_000537:p.Pro142Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.49387,1.7855535745620728,2.54966,0.6546399163450861,2.021765,1.0742549581725431,Uncertain,Neutral,Uncertain,Uncertain,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.23,E,-0.2722,0.1232,-6.9218,-4.83433291949262,0.0204288664631773,Benign,0.9794,pathogenic,-4.001,available,https://doi.org/10.1101/2022.10.22.513328 +P142L,NP_000537:p.Pro142Leu,"hg19,17:g.7578505G>A, hg38,17:g.7675187G>A",,3.9800678204e-06,0.879,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",864520,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.29286,1.4718420505523682,2.19966,-0.2963464675991661,1.74626,0.4982567662004169,Uncertain,Neutral,Uncertain,Neutral,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.23,E,-0.289,0.1232,-7.3368,-4.58121343403265,0.2239602580117152,Benign,0.8091,pathogenic,-3.843,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142M,NP_000537:p.Pro142Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.2329,1.5317997932434082,2.25068,-0.1065374009250386,1.74179,0.5631812995374808,Uncertain,Neutral,Uncertain,Neutral,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.23,E,-0.3159,0.1232,-22.2096,-6.6210502474622,0.5065179429060667,Uncertain,0.958,pathogenic,-4.283,available,https://doi.org/10.1101/2022.10.22.513328 +P142N,NP_000537:p.Pro142Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.44922,2.411781311035156,2.20068,0.3567927754779187,2.8249500000000003,1.9030063877389594,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.23,E,-0.3429,0.1232,-22.2096,-6.8749353022228,0.7917373049770209,Pathogenic,0.99,pathogenic,-4.173,available,https://doi.org/10.1101/2022.10.22.513328 +P142Q,NP_000537:p.Pro142Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.94884,2.021502494812012,2.35374,0.3365075803326001,2.15129,1.1426737901663,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.23,E,-0.3446,0.1232,-22.2096,-6.95843459535208,0.7123606444264704,Pathogenic,0.9289,pathogenic,-4.054,available,https://doi.org/10.1101/2022.10.22.513328 +P142R,NP_000537:p.Pro142Arg,"hg19,17:g.7578505G>C, hg19,17:g.7675187G>C",,,0.907,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.92975,1.9132031202316284,1.67075,0.1212653566123073,1.8002500000000001,1.0255076783061536,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.23,E,-0.386,0.1232,-22.2096,-7.02887704815977,0.4914263239347376,Uncertain,0.9261,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142S,NP_000537:p.Pro142Ser,"hg19,17:g.7578506G>A, hg38,17:g.7675188G>A",,,0.887,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",824720,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.92672,1.96623969078064,2.56327,0.3663358025711893,2.7449950000000003,1.6465279012855947,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.23,E,-0.3159,0.1232,-22.2096,-6.24313249476341,0.3751484077586338,Uncertain,0.8928,pathogenic,-3.922,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142T,NP_000537:p.Pro142Thr,"hg19,17:g.7578506G>T, hg38,17:g.7675188G>T",,,0.891,"COSMIC,ClinVar,saturation_mutlist",3972446,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.23884,1.846734404563904,2.12823,0.3233823095745447,2.183535,1.2811111547872724,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.23,E,-0.328,0.1232,-22.2096,-7.06923434007735,0.6110879105811937,Uncertain,0.8496,pathogenic,-3.993,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P142V,NP_000537:p.Pro142Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.67571,1.270538091659546,1.72279,-0.1238531775485263,1.6992500000000001,0.7759284112257369,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.23,E,-0.3157,0.1232,-22.2096,-6.6210502474622,0.8054277960443847,Pathogenic,0.9207,pathogenic,-4.169,available,https://doi.org/10.1101/2022.10.22.513328 +P142W,NP_000537:p.Pro142Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.01544,1.4908719062805176,2.69966,-0.6225739215217946,2.85755,1.1964330392391027,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.23,E,-0.3898,0.1232,-22.2096,-7.11434995405517,0.8512998771061207,Pathogenic,0.995,pathogenic,-4.668,available,https://doi.org/10.1101/2022.10.22.513328 +P142Y,NP_000537:p.Pro142Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.13797,1.5610642433166504,3.09184,-0.2044440664348568,2.6149050000000003,0.9667629667825717,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.186,,,,,,,,,20.1,,True,20.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.23,E,-0.3783,0.1232,-22.2096,-7.11434995405517,0.851405311774105,Pathogenic,0.993,pathogenic,-4.387,available,https://doi.org/10.1101/2022.10.22.513328 +V143A,NP_000537:p.Val143Ala,"hg19,17:g.7578502A>G, hg19,17:g.7675184A>G, hg38,17:g.7675184A>G",,,0.574,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",804214,Pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.67856,2.67444396018982,3.42211,3.3861192825869493,3.550335,3.5323396412934747,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.15,E,-0.2549,1.0422,-22.2096,-5.41695611372048,0.5729001861951852,Uncertain,0.9245,pathogenic,-3.942,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V143C,NP_000537:p.Val143Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.32709,1.556087613105774,2.63401,3.05623458494792,2.48055,2.69166229247396,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.15,E,-0.2828,1.0422,-22.2096,-6.58221124789451,0.8616209873815309,Pathogenic,0.9765,pathogenic,-4.307,available,https://doi.org/10.1101/2022.10.22.513328 +V143D,NP_000537:p.Val143Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.70649,3.490452527999878,4.91769,4.630433745191325,4.31209,4.168461872595662,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.15,E,-0.4215,1.0422,-22.2096,-7.13843299043174,0.8581243590003009,Pathogenic,0.9995,pathogenic,-4.729,available,https://doi.org/10.1101/2022.10.22.513328 +V143E,NP_000537:p.Val143Glu,"hg19,17:g.7578502A>T, hg19,17:g.7675184A>T, hg38,17:g.7675184A>T",,,0.683,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2687706,Uncertain significance,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.54247,3.357630968093872,4.54966,4.448625685372489,4.0460650000000005,3.9955478426862445,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.15,E,-0.3788,1.0422,-22.2096,-7.13843299043174,0.8429763782590516,Pathogenic,0.997,pathogenic,-4.671,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V143F,NP_000537:p.Val143Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.62363,2.3213448524475098,3.45748,2.799323879684169,4.540555,4.211476939842084,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.15,E,-0.3321,1.0422,-22.2096,-4.98535794148785,0.0222921461268485,Benign,0.8238,pathogenic,-3.648,available,https://doi.org/10.1101/2022.10.22.513328 +V143G,NP_000537:p.Val143Gly,"hg19,17:g.7578502A>C, hg19,17:g.7675184A>C, hg38,17:g.7675184A>C",,,0.692,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",486556,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.19089,3.3314695358276367,5.66667,5.493084301169207,5.42878,5.341987150584604,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.15,E,-0.3807,1.0422,-22.2096,-7.13843299043174,0.8544908051467128,Pathogenic,0.9773,pathogenic,-4.532,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V143H,NP_000537:p.Val143His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.79131,3.511429071426392,4.97891,3.5115214030095387,5.38511,4.651415701504769,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.15,E,-0.4245,1.0422,-22.2096,-5.80054592106197,0.8615191977464012,Pathogenic,0.9989,pathogenic,-4.484,available,https://doi.org/10.1101/2022.10.22.513328 +V143I,NP_000537:p.Val143Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.93651,0.1331195831298828,0.07823,0.7860261276118874,-0.42913999999999997,-0.07524193619405628,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.15,E,-0.0808,1.0422,-0.7173,-1.95319441454293,9.14274242289026e-05,Benign,0.1019,benign,-3.112,available,https://doi.org/10.1101/2022.10.22.513328 +V143K,NP_000537:p.Val143Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.27264,3.3971877098083496,6.03946,6.016621421734532,5.1560500000000005,5.144630710867267,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.15,E,-0.4178,1.0422,-22.2096,-7.13843299043174,0.8694876056189005,Pathogenic,0.998,pathogenic,-4.695,available,https://doi.org/10.1101/2022.10.22.513328 +V143L,NP_000537:p.Val143Leu,"hg19,17:g.7578503C>A, hg19,17:g.7578503C>G, hg38,17:g.7675185C>A, hg38,17:g.7675185C>G",,,0.607,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2687704, 185729","Uncertain significance, Uncertain significance","0, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.0585,1.2172595262527466,0.91395,1.1537061916997944,-0.07227499999999998,0.04760309584989719,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.15,E,-0.1775,1.0422,-6.9218,-2.09599099504191,0.123077284755386,Benign,0.5804,pathogenic,-3.398,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V143M,NP_000537:p.Val143Met,"hg19,17:g.7578503C>T, hg19,17:g.7675185C>T, hg38,17:g.7675185C>T",,,0.659,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142657,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.64318,1.9820435047149656,2.14184,1.9981669608367056,0.74933,0.6774934804183528,Uncertain,Neutral,Uncertain,Neutral,Neutral,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.15,E,-0.1968,1.0422,-8.9217,-2.51110586768785,0.2056673421361044,Benign,0.6458,pathogenic,-3.594,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V143N,NP_000537:p.Val143Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.38582,3.4742259979248047,3.9881,3.1498104241975136,3.68696,3.267815212098757,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.15,E,-0.4094,1.0422,-22.2096,-7.13843299043174,0.8623320274808599,Pathogenic,0.9975,pathogenic,-4.567,available,https://doi.org/10.1101/2022.10.22.513328 +V143P,NP_000537:p.Val143Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.65557,2.90056586265564,6.57789,6.6472525566278895,7.1167300000000004,7.151411278313945,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.15,E,-0.4593,1.0422,-22.2096,-7.13843299043174,0.8700024669657285,Pathogenic,0.9976,pathogenic,-4.549,available,https://doi.org/10.1101/2022.10.22.513328 +V143Q,NP_000537:p.Val143Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.7299,3.4348044395446777,3.26803,3.1881461748112887,2.998965,2.9590230874056447,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.15,E,-0.3894,1.0422,-22.2096,-7.13843299043174,0.869880225197027,Pathogenic,0.9952,pathogenic,-4.478,available,https://doi.org/10.1101/2022.10.22.513328 +V143R,NP_000537:p.Val143Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.51142,3.444336175918579,5.78197,5.151608820490392,7.646694999999999,7.3315144102451955,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.15,E,-0.4388,1.0422,-22.2096,-7.13843299043174,0.8636938516303572,Pathogenic,0.9952,pathogenic,-4.548,available,https://doi.org/10.1101/2022.10.22.513328 +V143S,NP_000537:p.Val143Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.3891,3.2331550121307373,4.21701,4.26941914456776,4.3030550000000005,4.329259572283879,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.15,E,-0.3586,1.0422,-22.2096,-6.58221124789451,0.86703187301884,Pathogenic,0.9884,pathogenic,-4.43,available,https://doi.org/10.1101/2022.10.22.513328 +V143T,NP_000537:p.Val143Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.10274,2.3762357234954834,2.19524,2.8642626834573006,2.14899,2.4835013417286502,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.15,E,-0.274,1.0422,-22.2096,-6.58221124789451,0.8702844570409342,Pathogenic,0.9674,pathogenic,-4.193,available,https://doi.org/10.1101/2022.10.22.513328 +V143W,NP_000537:p.Val143Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,14.96202,2.6581690311431885,3.88231,4.6671018846605845,9.422165,9.814560942330292,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.15,E,-0.3726,1.0422,-22.2096,-5.80054592106197,0.8570448113633149,Pathogenic,0.9981,pathogenic,-4.573,available,https://doi.org/10.1101/2022.10.22.513328 +V143Y,NP_000537:p.Val143Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.05398,2.833383798599243,3.97653,4.19670297844441,5.515255,5.625341489222205,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.178,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.15,E,-0.3755,1.0422,-22.2096,-5.80054592106197,0.8500562584249854,Pathogenic,0.9934,pathogenic,-4.455,available,https://doi.org/10.1101/2022.10.22.513328 +Q144A,NP_000537:p.Gln144Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.03944,0.8471373319625854,1.2068,0.2243457912304119,0.62312,0.13189289561520595,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.6,E,-0.2207,0.8595,-22.2125,-5.47584171679879,0.4485586435951262,Uncertain,0.6137,pathogenic,-3.871,available,https://doi.org/10.1101/2022.10.22.513328 +Q144C,NP_000537:p.Gln144Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.43974,0.2860833406448364,1.37279,0.5876020842995402,0.46652499999999997,0.07393104214977009,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,damaging,97.6,E,-0.2669,0.8595,-22.2125,-5.98492240284396,0.7848878441158132,Pathogenic,0.8954,pathogenic,-4.186,available,https://doi.org/10.1101/2022.10.22.513328 +Q144D,NP_000537:p.Gln144Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.45432,1.7666469812393188,1.36599,0.4481308328962791,1.410155,0.9512254164481395,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.6,E,-0.2251,0.8595,-6.1174,-2.26007412279668,0.0245010837691705,Benign,0.8812,pathogenic,-3.757,available,https://doi.org/10.1101/2022.10.22.513328 +Q144E,NP_000537:p.Gln144Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.6271,0.3972664475440979,0.37177,0.0894505472964074,0.49943499999999996,0.3582752736482037,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.6,E,-0.1308,0.8595,-3.6029,-2.21335131323574,0.0002972095025136,Benign,0.1697,benign,-3.423,available,https://doi.org/10.1101/2022.10.22.513328 +Q144F,NP_000537:p.Gln144Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.82174,0.0464402437210083,0.24762,-0.756690553153494,-0.78706,-1.2892152765767468,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.6,E,-0.2749,0.8595,-22.2125,-5.80797337508587,0.8261174098147788,Pathogenic,0.9385,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328 +Q144G,NP_000537:p.Gln144Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.5544,2.1147403717041016,2.94762,1.4306836446832478,2.25101,1.4925418223416238,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.6,E,-0.2154,0.8595,-7.3398,-4.12015796705344,0.0169859823897434,Benign,0.7243,pathogenic,-3.822,available,https://doi.org/10.1101/2022.10.22.513328 +Q144H,NP_000537:p.Gln144His,"hg19,17:g.7578498C>A, hg19,17:g.7578498C>G, hg19,17:g.7675180C>A, hg38,17:g.7675180C>A, hg38,17:g.7675180C>G",,,0.708,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376648,Uncertain significance,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.46041,0.5215426683425903,0.52925,-0.5822260348915698,0.49483,-0.06090801744578489,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.6,E,-0.1458,0.8595,-7.3398,-3.77890391248845,0.0130463691698117,Benign,0.628,pathogenic,-3.513,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q144I,NP_000537:p.Gln144Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.12783,0.4281381368637085,0.36122,-0.638030255170306,0.244525,-0.255100127585153,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.6,E,-0.2563,0.8595,-22.2125,-5.43354396044127,0.7763431997302048,Pathogenic,0.7989,pathogenic,-4.158,available,https://doi.org/10.1101/2022.10.22.513328 +Q144K,NP_000537:p.Gln144Lys,"hg19,17:g.7578500G>T, hg38,17:g.7675180_7675182delinsTTT, hg38,17:g.7675182G>T",,,0.763,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.22399,0.9971761703491212,0.58129,0.1852968053491571,-0.32134999999999997,-0.5193465973254214,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.6,E,-0.186,0.8595,-8.9247,-3.95325504913402,0.0718912139524061,Benign,0.335,benign,-3.602,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q144L,NP_000537:p.Gln144Leu,"hg19,17:g.7578499T>A, hg38,17:g.7675181T>A",,,0.764,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376647,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.64714,0.1421860456466674,-0.67109,-0.9952690151286236,-1.159115,-1.3212045075643117,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.6,E,-0.1541,0.8595,-5.4654,-3.41436173687567,3.806050357246926e-05,Benign,0.344,ambiguous,-3.501,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q144M,NP_000537:p.Gln144Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.99741,-0.1071375608444213,0.30136,-0.5966288573785627,-0.34802500000000003,-0.7970194286892813,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.6,E,-0.2106,0.8595,-22.2125,-4.81881838143923,0.172650180305833,Benign,0.6092,pathogenic,-3.99,available,https://doi.org/10.1101/2022.10.22.513328 +Q144N,NP_000537:p.Gln144Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.57953,1.546562433242798,0.70816,-0.0103422852294893,0.643845,0.28459385738525533,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.6,E,-0.2363,0.8595,-22.2125,-3.49462640305761,0.3237152411138149,Uncertain,0.6816,pathogenic,-3.779,available,https://doi.org/10.1101/2022.10.22.513328 +Q144P,NP_000537:p.Gln144Pro,"hg19,17:g.7578498_7578499delinsCC, hg19,17:g.7578498_7578499delinsGG, hg19,17:g.7578499T>G, hg19,17:g.7675181T>G, hg38,17:g.7675181T>G",,,0.801,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",186594,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.72571,3.264582633972168,2.5585,2.496697807844045,1.642105,1.6112039039220225,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.6,E,-0.3943,0.8595,-22.2125,-6.98438276993221,0.8401005732634821,Pathogenic,0.9497,pathogenic,-4.194,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q144R,NP_000537:p.Gln144Arg,"hg19,17:g.7578499T>C, hg38,17:g.7675181T>C",,,0.751,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2080519,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.82807,1.1158409118652344,1.13231,-0.2119840523690874,0.15211999999999998,-0.5200270261845437,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.6,E,-0.1846,0.8595,-8.9247,-4.06059577501546,0.0341927398105603,Benign,0.3028,benign,-3.554,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q144S,NP_000537:p.Gln144Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.8202,1.1064488887786863,2.1551,0.6086922384209698,1.48765,0.714446119210485,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.6,E,-0.1713,0.8595,-8.9247,-5.53088336738831,0.2756069615069493,Benign,0.6153,pathogenic,-3.73,available,https://doi.org/10.1101/2022.10.22.513328 +Q144T,NP_000537:p.Gln144Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.32264,1.2120516300201416,2.32925,0.1537071810370582,2.325945,1.238173590518529,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.6,E,-0.249,0.8595,-22.2125,-5.61368540392061,0.6134612442818825,Uncertain,0.5895,pathogenic,-3.847,available,https://doi.org/10.1101/2022.10.22.513328 +Q144V,NP_000537:p.Gln144Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.60445,0.7030535936355591,0.67279,-0.3595276987485374,0.63862,0.12246115062573132,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.6,E,-0.2563,0.8595,-22.2125,-5.68478873430795,0.8628468816897723,Pathogenic,0.6377,pathogenic,-4.071,available,https://doi.org/10.1101/2022.10.22.513328 +Q144W,NP_000537:p.Gln144Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.06748,0.3126943111419678,-0.45034,-0.9842118211297224,-0.19143000000000002,-0.4583659105648612,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.6,E,-0.2743,0.8595,-22.2125,-5.80797337508587,0.7773268836725387,Pathogenic,0.9178,pathogenic,-4.244,available,https://doi.org/10.1101/2022.10.22.513328 +Q144Y,NP_000537:p.Gln144Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.96382,0.0226420164108276,0.19286,-0.6410239125498091,-0.38548,-0.8024219562749045,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,,,,,,,21.6,,True,21.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.6,E,-0.2094,0.8595,-8.9247,-5.33989406687137,0.6409621918004836,Uncertain,0.8611,pathogenic,-4.095,available,https://doi.org/10.1101/2022.10.22.513328 +L145A,NP_000537:p.Leu145Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.25066,2.2988338470458984,3.3534,3.298364346898317,3.8020300000000002,3.7745121734491587,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.97,E,-0.2729,1.5915,-22.2125,-4.11494634629023,0.602466209859354,Uncertain,0.9049,pathogenic,-3.668,available,https://doi.org/10.1101/2022.10.22.513328 +L145C,NP_000537:p.Leu145Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.48195,1.3252079486846924,2.7568,3.00954152311534,3.119375,3.2457457615576697,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.97,E,-0.2622,1.5915,-22.2125,-5.68189181564467,0.5671343599064492,Uncertain,0.8445,pathogenic,-3.916,available,https://doi.org/10.1101/2022.10.22.513328 +L145D,NP_000537:p.Leu145Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.79571,3.639260768890381,3.62007,3.98306148898824,4.20789,4.38938574449412,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.97,E,-0.3944,1.5915,-22.2125,-6.46205310741211,0.6007461132985379,Uncertain,0.9993,pathogenic,-4.395,available,https://doi.org/10.1101/2022.10.22.513328 +L145E,NP_000537:p.Leu145Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.48308,3.308091163635254,3.84966,3.5260383160930986,4.166370000000001,4.00455915804655,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.97,E,-0.3625,1.5915,-22.2125,-6.46205310741211,0.6855090378534573,Pathogenic,0.9948,pathogenic,-4.27,available,https://doi.org/10.1101/2022.10.22.513328 +L145F,NP_000537:p.Leu145Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.8339,1.158320426940918,-0.12925,0.3393994311057913,1.352325,1.5866497155528956,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.97,E,-0.2064,1.5915,-22.2125,-3.55424145494716,0.0480485800956523,Benign,0.4941,ambiguous,-3.351,available,https://doi.org/10.1101/2022.10.22.513328 +L145G,NP_000537:p.Leu145Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.67421,3.039427757263184,5.79592,5.31836042025377,5.7350650000000005,5.496285210126885,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.97,E,-0.3478,1.5915,-22.2125,-6.46205310741211,0.7598256505962272,Pathogenic,0.9865,pathogenic,-4.157,available,https://doi.org/10.1101/2022.10.22.513328 +L145H,NP_000537:p.Leu145His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.78086,2.904225826263428,2.21088,1.9900536483431563,2.99587,2.885456824171578,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.97,E,-0.3153,1.5915,-22.2125,-4.66303097954973,0.4946614943882225,Uncertain,0.9861,pathogenic,-4.281,available,https://doi.org/10.1101/2022.10.22.513328 +L145I,NP_000537:p.Leu145Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.27922,-0.2710063457489013,-0.19252,0.7446047594978028,0.043350000000000014,0.5119123797489014,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.97,E,-0.0374,1.5915,-0.7202,-1.68455958088278,1.280998235892722e-06,Benign,0.1191,benign,-2.908,available,https://doi.org/10.1101/2022.10.22.513328 +L145K,NP_000537:p.Leu145Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.57947,2.859920024871826,5.45034,4.778493362293502,4.014905,3.678981681146751,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.97,E,-0.3615,1.5915,-22.2125,-6.46205310741211,0.6447415176660134,Uncertain,0.9946,pathogenic,-4.267,available,https://doi.org/10.1101/2022.10.22.513328 +L145M,NP_000537:p.Leu145Met,"hg19,17:g.7578497G>T, hg38,17:g.7675179G>T",,,0.505,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.52022,1.105428695678711,0.85544,1.147892824847307,0.16760999999999998,0.3138364124236535,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.97,E,-0.077,1.5915,-3.9248,-1.64445050242912,5.912657478302182e-05,Benign,0.2145,benign,-3.025,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L145N,NP_000537:p.Leu145Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.51227,3.252495765686035,2.7432,2.749641311011156,3.127735,3.130955655505578,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.97,E,-0.3407,1.5915,-22.2125,-6.46205310741211,0.5817329726016456,Uncertain,0.9951,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328 +L145P,NP_000537:p.Leu145Pro,"hg19,17:g.7578496A>G, hg19,17:g.7675178A>G, hg38,17:g.7675178A>G",,0.0,0.818,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142050,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.19688,3.178845167160034,4.97823,7.1777254718929,5.587555,6.68730273594645,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.97,E,-0.2885,1.5915,-8.9247,-4.11807604586948,0.1509902756751129,Benign,0.9946,pathogenic,-4.03,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L145Q,NP_000537:p.Leu145Gln,"hg19,17:g.7578496A>T, hg19,17:g.7675178A>T, hg38,17:g.7675178A>T",,,0.846,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480760,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.02432,3.1052439212799072,1.79184,2.648115488158426,2.40808,2.836217744079213,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.97,E,-0.2937,1.5915,-22.2125,-6.46205310741211,0.6961265374088593,Pathogenic,0.9799,pathogenic,-4.188,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L145R,NP_000537:p.Leu145Arg,"hg19,17:g.7578495_7578496delinsAC, hg19,17:g.7578496A>C, hg19,17:g.7675177_7675178delinsAC, hg19,17:g.7675178A>C, hg38,17:g.7675177_7675178delinsAC, hg38,17:g.7675178A>C",,,0.845,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1027110,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.64407,2.8611953258514404,5.87959,3.535144573609464,6.26183,5.089607286804732,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.97,E,-0.2853,1.5915,-8.9247,-6.46205310741211,0.0354268228068004,Benign,0.9863,pathogenic,-3.964,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L145S,NP_000537:p.Leu145Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.16088,3.0339176654815674,3.91497,4.050855128418441,4.5379249999999995,4.60586756420922,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.97,E,-0.3033,1.5915,-22.2125,-5.68189181564467,0.4704830036412578,Uncertain,0.9872,pathogenic,-4.13,available,https://doi.org/10.1101/2022.10.22.513328 +L145T,NP_000537:p.Leu145Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.48057,2.3387820720672607,2.84626,2.8763953247583327,3.163415,3.1784826623791664,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.97,E,-0.2082,1.5915,-8.9247,-4.10483296448931,0.3989900369135243,Uncertain,0.9443,pathogenic,-3.857,available,https://doi.org/10.1101/2022.10.22.513328 +L145V,NP_000537:p.Leu145Val,"hg19,17:g.7578497G>C, hg38,17:g.7675179G>C",,,0.462,"COSMIC,ClinVar,saturation_mutlist",2774652,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.63522,0.3345391750335693,0.73605,1.286604929823269,1.185635,1.4609124649116345,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.97,E,-0.0848,1.5915,-2.9024,-0.436000769096075,9.085797244172356e-07,Benign,0.1076,benign,-2.912,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L145W,NP_000537:p.Leu145Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.08498,1.9345362186431885,2.85306,1.7069879177035745,5.96902,5.3959839588517875,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.97,E,-0.3055,1.5915,-22.2125,-4.66303097954973,0.7512209210830842,Pathogenic,0.9454,pathogenic,-4.201,available,https://doi.org/10.1101/2022.10.22.513328 +L145Y,NP_000537:p.Leu145Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.13803,1.7386834621429443,0.81463,1.2773524690376663,2.97633,3.207691234518833,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,True,0.34,,,,,,,,,0.5,,False,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.97,E,-0.2984,1.5915,-22.2125,-3.81897848775477,0.0532419531893655,Benign,0.9558,pathogenic,-3.866,available,https://doi.org/10.1101/2022.10.22.513328 +W146A,NP_000537:p.Trp146Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.37594,1.9984452724456787,2.56599,3.066879803733129,1.970965,2.2214099018665645,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.3301,1.8527,-7.3368,-2.33091563655778,0.0151140715084037,Benign,0.5144,ambiguous,-3.24,available,https://doi.org/10.1101/2022.10.22.513328 +W146C,NP_000537:p.Trp146Cys,"hg19,17:g.7578492C>A, hg19,17:g.7578492C>G, hg38,17:g.7675174C>A, hg38,17:g.7675174C>G",,,0.629,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","1740219, 824855","Uncertain significance, Uncertain significance","1, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.14706,0.3048429489135742,2.63878,3.338325922896407,1.8929200000000002,2.2426929614482036,Uncertain,Uncertain,Neutral,Neutral,Uncertain,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,damaging,97.91,E,-0.3418,1.8527,-22.2096,-4.39907503912101,0.1421786878392424,Benign,0.6342,pathogenic,-3.606,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +W146D,NP_000537:p.Trp146Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.71975,2.9467055797576904,3.19592,3.7087241215234905,2.957835,3.214237060761745,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.4303,1.8527,-22.2096,-4.31205841423562,0.2443854002501679,Benign,0.8742,pathogenic,-3.664,available,https://doi.org/10.1101/2022.10.22.513328 +W146E,NP_000537:p.Trp146Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.28214,1.88507616519928,2.45612,3.3227937951504365,1.86913,2.3024668975752185,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.3688,1.8527,-6.3369,-2.51043412235874,0.0031625471499654,Benign,0.7421,pathogenic,-3.298,available,https://doi.org/10.1101/2022.10.22.513328 +W146F,NP_000537:p.Trp146Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.70756,-0.0546942949295043,0.42245,0.9233578150589268,-0.142555,0.1078989075294634,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.1908,1.8527,-8.9217,-1.69430611884554,0.0062870663276241,Benign,0.2585,benign,-3.327,available,https://doi.org/10.1101/2022.10.22.513328 +W146G,NP_000537:p.Trp146Gly,"hg19,17:g.7578494A>C, hg38,17:g.7675176A>C",,,0.536,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",186587,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.47372,2.515984535217285,4.04422,4.507619061395387,3.25897,3.4906695306976934,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.3912,1.8527,-22.2096,-4.88435409899919,0.0244414092070777,Benign,0.5479,ambiguous,-3.628,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +W146H,NP_000537:p.Trp146His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.31288,0.949798345565796,0.85578,2.377061966725759,1.08433,1.8449709833628796,Neutral,Uncertain,Neutral,Neutral,Neutral,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.3943,1.8527,-22.2096,-1.73419688470807,2.4505945825635267e-05,Benign,0.5021,ambiguous,-3.182,available,https://doi.org/10.1101/2022.10.22.513328 +W146I,NP_000537:p.Trp146Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.43388,0.6148771047592163,0.69014,1.7324795832104891,0.12813,0.6492997916052445,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.3189,1.8527,-7.9218,-2.3525230187613,0.0269628373788254,Benign,0.5628,ambiguous,-3.441,available,https://doi.org/10.1101/2022.10.22.513328 +W146K,NP_000537:p.Trp146Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.59338,1.4304542541503906,2.17585,3.288319845695097,1.3846150000000002,1.9408499228475486,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.3521,1.8527,-0.7124,-1.02914875730179,2.477580449200688e-07,Benign,0.675,pathogenic,-2.973,available,https://doi.org/10.1101/2022.10.22.513328 +W146L,NP_000537:p.Trp146Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.39415,0.7084125280380249,0.79082,1.7034899722023324,0.19833499999999998,0.6546699861011662,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.2574,1.8527,-3.3983,-0.453222983900895,5.442517842699088e-05,Benign,0.3508,ambiguous,-3.072,available,https://doi.org/10.1101/2022.10.22.513328 +W146M,NP_000537:p.Trp146Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.02134,0.7672793865203857,1.91531,2.014571929642228,0.9469850000000001,0.9966159648211141,Neutral,Uncertain,Neutral,Neutral,Neutral,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.2926,1.8527,-7.9218,-1.86333475052515,0.0043266556808526,Benign,0.514,ambiguous,-3.42,available,https://doi.org/10.1101/2022.10.22.513328 +W146N,NP_000537:p.Trp146Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.16995,1.8610337972640991,2.51599,3.114788309770525,2.34297,2.6423691548852624,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.4385,1.8527,-22.2096,-4.57329976438315,0.0881462176403514,Benign,0.805,pathogenic,-3.474,available,https://doi.org/10.1101/2022.10.22.513328 +W146P,NP_000537:p.Trp146Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.08747,3.3019356727600098,3.38265,6.984852353061598,3.73506,5.536161176530799,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.4767,1.8527,-22.2096,-5.68979558297274,0.3400819381345366,Uncertain,0.9937,pathogenic,-3.884,available,https://doi.org/10.1101/2022.10.22.513328 +W146Q,NP_000537:p.Trp146Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.64759,1.472983956336975,2.01735,2.9309594267394443,1.33247,1.7892747133697222,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.3513,1.8527,-6.9218,-2.48562344942259,0.0012831561340812,Benign,0.5876,pathogenic,-3.136,available,https://doi.org/10.1101/2022.10.22.513328 +W146R,NP_000537:p.Trp146Arg,"hg38,17:g.7675176A>G, hg38,17:g.7675176A>T",,,0.464,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.21102,1.323617458343506,1.89252,2.634369861970982,1.5517699999999999,1.922694930985491,Neutral,Uncertain,Uncertain,Neutral,Neutral,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.3031,1.8527,-5.2214,-1.04959842261786,1.2106439667860752e-05,Benign,0.5671,pathogenic,-2.98,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +W146S,NP_000537:p.Trp146Ser,"hg19,17:g.7578493C>G, hg19,17:g.7675175C>G, hg38,17:g.7675175C>G",,,0.521,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.23551,1.6655848026275637,3.19558,3.673958362751385,2.715545,2.9547341813756924,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.4041,1.8527,-22.2096,-3.56781936813426,0.002140907001527,Benign,0.3925,ambiguous,-3.262,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +W146T,NP_000537:p.Trp146Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.37079,1.3362830877304075,2.44252,2.914282508539859,1.906655,2.1425362542699293,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.3718,1.8527,-7.3368,-2.18213104316455,0.0001103002188972,Benign,0.4427,ambiguous,-3.099,available,https://doi.org/10.1101/2022.10.22.513328 +W146V,NP_000537:p.Trp146Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.2521,0.670922040939331,0.95476,1.940286518992812,0.60343,1.0961932594964061,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.2944,1.8527,-4.7519,-1.76708133306087,1.990571766854424e-05,Benign,0.4597,ambiguous,-3.12,available,https://doi.org/10.1101/2022.10.22.513328 +W146Y,NP_000537:p.Trp146Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.91892,0.044324517250061,-0.02823,1.228140597519956,-0.47357499999999997,0.154610298759978,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.507,,,Uncertain,,Uncertain,,,Uncertain,29.3,,False,29.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.91,E,-0.2387,1.8527,-8.9217,-1.52105448558601,0.1925520307473832,Benign,0.3846,ambiguous,-3.372,available,https://doi.org/10.1101/2022.10.22.513328 +V147A,NP_000537:p.Val147Ala,"hg19,17:g.7578490A>G, hg38,17:g.7675172A>G",,,0.812,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",842812,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.7211,1.818700909614563,1.21633,2.4320840305275286,1.468715,2.0765920152637642,Neutral,Uncertain,Uncertain,Neutral,Uncertain,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.61,-,-0.3045,0.5036,-22.2096,-4.29904961719234,0.1554233101588092,Benign,0.5938,pathogenic,-3.678,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V147C,NP_000537:p.Val147Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.76259,1.191397786140442,1.69796,2.197521723955144,1.230275,1.4800558619775719,Neutral,Uncertain,Uncertain,Neutral,Neutral,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.61,-,-0.3324,0.5036,-22.2096,-3.83219042712051,0.4191857340062551,Uncertain,0.8732,pathogenic,-3.691,available,https://doi.org/10.1101/2022.10.22.513328 +V147D,NP_000537:p.Val147Asp,"hg19,17:g.7578490A>T, hg19,17:g.7675172A>T, hg38,17:g.7675172A>T",,,0.896,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1351017,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.48812,3.2303659915924072,2.20272,3.256957487040548,1.8454199999999998,2.3725387435202743,Uncertain,Uncertain,Destabilizing,Neutral,Uncertain,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.61,-,-0.4711,0.5036,-22.2096,-6.60001975419788,0.8378373379244817,Pathogenic,0.9858,pathogenic,-4.354,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V147E,NP_000537:p.Val147Glu,"hg38,17:g.7675171_7675172inv",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.60058,3.187498092651367,2.72449,2.9881222620670256,2.162535,2.2943511310335127,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.61,-,-0.4284,0.5036,-22.2096,-6.60001975419788,0.8526580998730378,Pathogenic,0.9668,pathogenic,-4.306,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V147F,NP_000537:p.Val147Phe,"hg38,17:g.7675173C>A",,,0.747,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.25609,1.467196345329285,0.22483,0.1521263137623479,1.24046,1.204108156881174,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,97.61,-,-0.3057,0.5036,-7.3368,-1.76724972552787,0.6789632646602263,Uncertain,0.6895,pathogenic,-3.739,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V147G,NP_000537:p.Val147Gly,"hg19,17:g.7578490A>C, hg19,17:g.7675172A>C, hg38,17:g.7675172A>C",,,0.895,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3602769,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.77782,2.879767656326294,2.6051,4.110423184777943,2.69146,3.4441215923889716,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.61,-,-0.4303,0.5036,-22.2096,-6.60001975419788,0.8137922732719153,Pathogenic,0.6169,pathogenic,-4.106,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V147H,NP_000537:p.Val147His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.42857,2.759815216064453,1.23673,1.5371818256319931,1.8326500000000001,1.9828759128159965,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,97.61,-,-0.4741,0.5036,-22.2096,-5.32163014695496,0.8036522917447922,Pathogenic,0.9883,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328 +V147I,NP_000537:p.Val147Ile,"hg19,17:g.7578491C>T, hg38,17:g.7675173C>T",,,0.549,"COSMIC,ClinVar,saturation_mutlist",528255,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.12943,0.4027855396270752,-0.10986,0.0799707280776163,-0.119645,-0.024729635961191848,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,97.61,-,-0.1671,0.5036,-7.9218,-2.44074556637347,0.3450712461101911,Uncertain,0.2039,benign,-3.514,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V147K,NP_000537:p.Val147Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.56502,3.1725082397460938,3.53605,3.3928217982377404,3.050535,2.9789208991188705,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,97.61,-,-0.4673,0.5036,-22.2096,-6.60001975419788,0.8612447946939559,Pathogenic,0.9786,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +V147L,NP_000537:p.Val147Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.44788,1.4526877403259275,-0.15102,-0.0006893923368744,-0.29945,-0.2242846961684372,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,97.61,-,-0.2152,0.5036,-4.5999,-2.1594368414436,0.000619043819819,Benign,0.4268,ambiguous,-3.189,available,https://doi.org/10.1101/2022.10.22.513328 +V147M,NP_000537:p.Val147Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.68818,1.7843296527862549,0.53129,0.6854994488432586,0.609735,0.6868397244216293,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,97.61,-,-0.2332,0.5036,-6.3369,-2.08304348806462,0.0004735383653707,Benign,0.3729,ambiguous,-3.383,available,https://doi.org/10.1101/2022.10.22.513328 +V147N,NP_000537:p.Val147Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.24672,3.1254091262817383,1.60204,2.157049250337694,1.42438,1.701884625168847,Neutral,Uncertain,Destabilizing,Neutral,Neutral,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.61,-,-0.4589,0.5036,-22.2096,-6.60001975419788,0.8002469178034609,Pathogenic,0.9533,pathogenic,-4.287,available,https://doi.org/10.1101/2022.10.22.513328 +V147P,NP_000537:p.Val147Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.49756,3.0992794036865234,2.47789,4.423516260787397,2.487725,3.4605381303936986,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.61,-,-0.5088,0.5036,-22.2096,-6.60001975419788,0.8112710505848709,Pathogenic,0.9883,pathogenic,-4.11,available,https://doi.org/10.1101/2022.10.22.513328 +V147Q,NP_000537:p.Val147Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.4605,2.998044729232788,1.80272,1.9371740450761867,1.63161,1.6988370225380933,Neutral,Neutral,Destabilizing,Neutral,Neutral,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.61,-,-0.439,0.5036,-22.2096,-6.60001975419788,0.8273378144396569,Pathogenic,0.9648,pathogenic,-4.104,available,https://doi.org/10.1101/2022.10.22.513328 +V147R,NP_000537:p.Val147Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.83594,2.9556124210357666,2.06395,2.204450388899516,2.449945,2.520195194449758,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,97.61,-,-0.4884,0.5036,-22.2096,-6.60001975419788,0.8539653538854353,Pathogenic,0.9647,pathogenic,-4.26,available,https://doi.org/10.1101/2022.10.22.513328 +V147S,NP_000537:p.Val147Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.60225,2.330068588256836,1.72211,3.079516915006065,1.66218,2.3408834575030326,Neutral,Uncertain,Destabilizing,Neutral,Uncertain,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.61,-,-0.4081,0.5036,-22.2096,-3.95248303533272,0.496367070951342,Uncertain,0.8128,pathogenic,-3.888,available,https://doi.org/10.1101/2022.10.22.513328 +V147T,NP_000537:p.Val147Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30735,1.3794130086898804,1.40034,2.056816455213301,0.853845,1.1820832276066504,Neutral,Uncertain,Uncertain,Neutral,Neutral,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.61,-,-0.2455,0.5036,-6.9218,-2.61569002291227,0.002320868353933,Benign,0.3624,ambiguous,-3.366,available,https://doi.org/10.1101/2022.10.22.513328 +V147W,NP_000537:p.Val147Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.86893,1.9860994815826416,2.85442,0.9015353388187058,3.861675,2.8852326694093526,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,97.61,-,-0.4222,0.5036,-22.2096,-4.98433149263082,0.2327838000471104,Benign,0.9882,pathogenic,-3.96,available,https://doi.org/10.1101/2022.10.22.513328 +V147Y,NP_000537:p.Val147Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.65266,1.7164889574050903,0.95544,0.8352515996759458,2.30405,2.243955799837973,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.319,,,,,,,,,6.7,,True,6.7,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,97.61,-,-0.4251,0.5036,-22.2096,-5.10837726795603,0.6503537677826763,Uncertain,0.9724,pathogenic,-3.99,available,https://doi.org/10.1101/2022.10.22.513328 +D148A,NP_000537:p.Asp148Ala,"hg19,17:g.7578487T>G, hg38,17:g.7675169T>G",,,0.404,"ClinVar,saturation_mutlist",485032,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35296,0.3362877964973449,0.95646,0.8278633448901684,0.65471,0.5904116724450842,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.0152,2.6864,-5.3369,-0.334270581908593,6.617034226686461e-10,Benign,0.1061,benign,-2.956,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D148C,NP_000537:p.Asp148Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22458,0.0867772102355957,1.39932,1.3124438013719446,0.81195,0.7685119006859723,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.64,S,-0.075,2.6864,-8.9217,-1.20584410401836,0.0008610289024357,Benign,0.339,benign,-3.332,available,https://doi.org/10.1101/2022.10.22.513328 +D148E,NP_000537:p.Asp148Glu,"hg19,17:g.7578486A>C, hg19,17:g.7578486A>T, hg38,17:g.7675168A>C, hg38,17:g.7675168A>T",,,0.289,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1478891,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.11046,0.3173981308937073,-0.09218,0.5077459874640613,0.009140000000000002,0.30910299373203065,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,S,0.0392,2.6864,-5.4624,-0.292296604278704,1.588519523802838e-08,Benign,0.1156,benign,-2.87,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D148F,NP_000537:p.Asp148Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.52911,0.6953854560852051,0.3466,0.4158156569870602,0.437855,0.47246282849353005,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.2015,2.6864,-22.2096,-3.47422679014876,0.005093223166417,Benign,0.4713,ambiguous,-3.587,available,https://doi.org/10.1101/2022.10.22.513328 +D148G,NP_000537:p.Asp148Gly,"hg19,17:g.7578487T>C, hg19,17:g.7675169T>C, hg38,17:g.7675169T>C",,,0.467,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.52389,0.8749624490737915,1.7102,1.295117609426989,1.117045,0.9095038047134945,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.0294,2.6864,-5.9218,-1.80105349013127,2.1571931350358533e-08,Benign,0.1079,benign,-3.002,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D148H,NP_000537:p.Asp148His,"hg19,17:g.7578488C>G, hg19,17:g.7675170C>G, hg38,17:g.7675170C>G",,,0.482,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.65903,0.5021692514419556,0.81837,0.2510624594952032,0.7387,0.4550462297476016,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.1107,2.6864,-22.2096,-2.84148321697135,0.0001859009476552,Benign,0.1571,benign,-3.238,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D148I,NP_000537:p.Asp148Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.0889,0.4799097776412964,1.27823,0.4088868972244347,0.683565,0.24889344861221735,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.1259,2.6864,-8.9217,-1.2262573792571,0.0001583770400177,Benign,0.2932,benign,-3.392,available,https://doi.org/10.1101/2022.10.22.513328 +D148K,NP_000537:p.Asp148Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.04255,0.5631849765777588,0.57959,0.5497372251735455,0.31107,0.29614361258677274,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.0992,2.6864,-7.9218,-1.60860474942785,9.758280601214073e-08,Benign,0.2374,benign,-3.133,available,https://doi.org/10.1101/2022.10.22.513328 +D148L,NP_000537:p.Asp148Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.32398,0.3488392233848572,0.44864,0.1470076742103054,0.38631,0.2354938371051527,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.0889,2.6864,-2.9218,-1.27920062530759,1.0836121455665938e-05,Benign,0.2614,benign,-3.168,available,https://doi.org/10.1101/2022.10.22.513328 +D148M,NP_000537:p.Asp148Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.05553,0.3914121389389038,0.78707,0.4970192655415723,0.4213,0.2762746327707861,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.0217,2.6864,-1.7519,-1.28055057566239,0.0001163911311489,Benign,0.4263,ambiguous,-3.306,available,https://doi.org/10.1101/2022.10.22.513328 +D148N,NP_000537:p.Asp148Asn,"hg19,17:g.7578488C>T, hg19,17:g.7675170C>T, hg38,17:g.7675170C>T",,,0.277,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",568069,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.94688,-0.0049995183944702,0.42177,0.3873813083214666,-0.26255500000000004,-0.2797493458392667,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.64,S,0.0222,2.6864,-4.5295,-0.336671300426911,1.632867440977589e-09,Benign,0.0719,benign,-2.869,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D148P,NP_000537:p.Asp148Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42808,2.7839646339416504,1.88367,2.944619357960583,1.655875,2.1863496789802914,Neutral,Uncertain,Destabilizing,Neutral,Uncertain,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.64,S,-0.2383,2.6864,-22.2096,-3.91190764584153,5.193254412519911e-05,Benign,0.6418,pathogenic,-3.351,available,https://doi.org/10.1101/2022.10.22.513328 +D148Q,NP_000537:p.Asp148Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.3236,0.3696535229682922,0.39592,0.7747797948636503,0.35975999999999997,0.5491898974318252,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.0605,2.6864,-8.9217,-1.28091288379219,3.536137760973022e-06,Benign,0.1844,benign,-3.088,available,https://doi.org/10.1101/2022.10.22.513328 +D148R,NP_000537:p.Asp148Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22139,0.3738359808921814,0.68265,0.3796437758808474,0.45202,0.3005168879404237,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.1251,2.6864,-6.9218,-0.680094235195205,1.1249936849555423e-06,Benign,0.2281,benign,-3.162,available,https://doi.org/10.1101/2022.10.22.513328 +D148S,NP_000537:p.Asp148Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.53995,0.0964823961257934,0.75986,0.7257447077905216,0.649905,0.6328473538952608,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.0038,2.6864,-1.8344,0.0247349799681672,5.0862238466257574e-14,Benign,0.0713,benign,-2.779,available,https://doi.org/10.1101/2022.10.22.513328 +D148T,NP_000537:p.Asp148Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.74457,0.042582631111145,0.54218,0.6153149299493132,0.643375,0.6799424649746566,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.64,S,-0.0469,2.6864,-4.3983,-0.0770725391737,3.2718042238375694e-13,Benign,0.1162,benign,-2.852,available,https://doi.org/10.1101/2022.10.22.513328 +D148V,NP_000537:p.Asp148Val,"hg19,17:g.7578487T>A, hg38,17:g.7675169T>A",,,0.551,"COSMIC,ClinVar,saturation_mutlist",2687708,Uncertain significance,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.53167,0.4690901041030884,1.1085,0.5277514644013437,0.820085,0.5297107322006718,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.1484,2.6864,-22.2096,-1.36574732863833,1.7556134673725282e-05,Benign,0.1965,benign,-3.218,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D148W,NP_000537:p.Asp148Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.37994,0.927296221256256,1.02653,0.0279453271864027,0.7032349999999999,0.20394266359320135,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.1819,2.6864,-22.2096,-3.47422679014876,0.0069127030284249,Benign,0.7607,pathogenic,-3.7,available,https://doi.org/10.1101/2022.10.22.513328 +D148Y,NP_000537:p.Asp148Tyr,"hg19,17:g.7578488C>A, hg38,17:g.7675170C>A",,3.9790859244e-06,0.531,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428863,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.66416,0.8174095153808594,0.14728,0.4321199749122123,0.40571999999999997,0.5481399874561061,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.079,,,Uncertain,,Uncertain,,,Uncertain,69.7,,True,69.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.64,S,-0.1463,2.6864,-22.2096,-3.47422679014876,0.0298127752522772,Benign,0.208,benign,-3.641,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S149A,NP_000537:p.Ser149Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.16931,0.0687947273254394,0.01293,-0.2452610208691813,0.09111999999999999,-0.03797551043459066,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,95.78,S,-0.003,2.0855,-5.4654,-0.441886299497982,0.0001505148817471,Benign,0.0651,benign,-3.138,available,https://doi.org/10.1101/2022.10.22.513328 +S149C,NP_000537:p.Ser149Cys,"hg19,17:g.7578484G>C, hg38,17:g.7675166G>C",,,0.482,"ClinVar,saturation_mutlist",3328163,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.00674,-0.0932427644729614,0.35816,0.3415098444027425,0.18245,0.17412492220137127,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.1389,2.0855,-22.2125,-2.47381113141007,0.2357008286893609,Benign,0.0758,benign,-3.57,available,https://doi.org/10.1101/2022.10.22.513328 +S149D,NP_000537:p.Ser149Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.20615,1.2874152660369873,0.67993,0.2055012675383516,0.23689000000000002,-0.0003243662308241996,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.1112,2.0855,-7.3398,-1.31671889963374,0.0635294872058832,Benign,0.2592,benign,-3.541,available,https://doi.org/10.1101/2022.10.22.513328 +S149E,NP_000537:p.Ser149Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.33917,0.7300797700881958,0.22211,-0.1137209017440676,-0.05853000000000001,-0.22644545087203383,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.0844,2.0855,-7.3398,-2.46496811433743,0.0047011292292298,Benign,0.3048,benign,-3.427,available,https://doi.org/10.1101/2022.10.22.513328 +S149F,NP_000537:p.Ser149Phe,"hg19,17:g.7578484G>A, hg38,17:g.7675165_7675166delinsAA, hg38,17:g.7675166G>A",,,0.457,"COSMIC,ClinVar,saturation_mutlist",486559,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.35851,0.1726640462875366,-0.66701,-0.6584262940876418,-0.51276,-0.5084681470438208,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.0906,2.0855,-7.3398,-2.29251350000616,0.0174306977084863,Benign,0.1304,benign,-3.408,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S149G,NP_000537:p.Ser149Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.42609,0.8343596458435059,1.25884,0.5916687643355641,0.842465,0.5088793821677821,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,DOWN,neutral,neutral,False,neutral,neutral,95.78,S,-0.018,2.0855,-6.6029,-2.69038127217085,0.0005422564016362,Benign,0.0908,benign,-3.234,available,https://doi.org/10.1101/2022.10.22.513328 +S149H,NP_000537:p.Ser149His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35349,0.319590151309967,-0.45102,-0.5509534210308042,-0.048764999999999975,-0.09873171051540211,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.0881,2.0855,-6.6029,-2.28467469963585,0.0001606034394828,Benign,0.195,benign,-3.26,available,https://doi.org/10.1101/2022.10.22.513328 +S149I,NP_000537:p.Ser149Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.50615,0.0580016374588012,-0.89796,-0.6744440349760072,-0.702055,-0.5902970174880036,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.1696,2.0855,-22.2125,-3.57240385221268,0.0543290273440125,Benign,0.1517,benign,-3.64,available,https://doi.org/10.1101/2022.10.22.513328 +S149K,NP_000537:p.Ser149Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.33887,0.0183831453323364,-0.36837,-0.3957504133198619,-0.35362,-0.36731020665993097,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.0833,2.0855,-3.8374,-2.25649660515639,0.0003346668722222,Benign,0.3828,ambiguous,-3.246,available,https://doi.org/10.1101/2022.10.22.513328 +S149L,NP_000537:p.Ser149Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.66375,0.3568839430809021,-0.54762,-0.8636751810362947,-0.605685,-0.7637125905181473,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.09,2.0855,-7.3398,-1.20887317566972,0.0002326407701198,Benign,0.0907,benign,-3.29,available,https://doi.org/10.1101/2022.10.22.513328 +S149M,NP_000537:p.Ser149Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.53034,0.081899881362915,-0.34014,-0.357245453333001,-0.43524,-0.4437927266665005,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.064,2.0855,-7.9247,-2.33079840305445,0.0670440033658271,Benign,0.1457,benign,-3.616,available,https://doi.org/10.1101/2022.10.22.513328 +S149N,NP_000537:p.Ser149Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.15056,0.5122331380844116,0.05578,-0.0605762363284012,0.10317,0.0449918818357994,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.0311,2.0855,-6.6029,-2.17419214764211,0.0003529237507555,Benign,0.1281,benign,-3.171,available,https://doi.org/10.1101/2022.10.22.513328 +S149P,NP_000537:p.Ser149Pro,"hg19,17:g.7578485A>G, hg38,17:g.7675167A>G",,,0.558,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2679232,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.37208,2.7125401496887207,5.46122,2.2443936752847744,3.4166499999999997,1.8082368376423872,Uncertain,Uncertain,Destabilizing,Destabilizing,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.2419,2.0855,-22.2125,-3.23974064391757,0.178062403996352,Benign,0.5992,pathogenic,-3.482,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S149Q,NP_000537:p.Ser149Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.09616,0.1688116192817688,-0.03231,-0.0631328105856504,-0.064235,-0.0796464052928252,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.0507,2.0855,-6.6029,-2.16255306307816,0.0001592529843122,Benign,0.2758,benign,-3.198,available,https://doi.org/10.1101/2022.10.22.513328 +S149R,NP_000537:p.Ser149Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.43722,-0.183141827583313,-0.47415,-0.7861386315003671,-0.455685,-0.6116793157501835,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.0983,2.0855,-5.7549,-2.1182382503908,0.0001924324827332,Benign,0.3187,benign,-3.288,available,https://doi.org/10.1101/2022.10.22.513328 +S149T,NP_000537:p.Ser149Thr,"hg38,17:g.7675167A>T",,,0.327,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01936,-0.031564712524414,-0.07551,-0.2078799617552185,-0.028074999999999996,-0.09425998087760926,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,neutral,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,0.0298,2.0855,-0.8587,-1.28064812545963,0.0004273463182668,Benign,0.0641,benign,-3.08,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S149V,NP_000537:p.Ser149Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.11673,-0.0894132852554321,-0.9034,-0.5071959125398984,-0.510065,-0.3119629562699492,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.0578,2.0855,-5.3398,-2.06093296271041,0.0002813740895691,Benign,0.1229,benign,-3.21,available,https://doi.org/10.1101/2022.10.22.513328 +S149W,NP_000537:p.Ser149Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.00607,0.4743606448173523,-0.11803,-1.0085222832280898,-0.06205,-0.5072961416140449,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,damaging,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.1762,2.0855,-22.2125,-3.93529936534686,0.3687759200559155,Uncertain,0.27,benign,-3.946,available,https://doi.org/10.1101/2022.10.22.513328 +S149Y,NP_000537:p.Ser149Tyr,"hg19,17:g.7578484G>T, hg38,17:g.7675166G>T",,,0.448,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2754115,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.23339,0.2935299873352051,-0.87925,-0.6688268294279337,-0.5563199999999999,-0.45110841471396684,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,72.3,P,True,72.3,-0.227,uncertain,neutral,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,95.78,S,-0.1713,2.0855,-22.2125,-3.6432437730098,0.1688355168999101,Benign,0.1357,benign,-3.568,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T150A,NP_000537:p.Thr150Ala,"hg38,17:g.7675164T>C",,,0.333,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.47616,0.4897471666336059,0.6398,0.285851053634239,0.55798,0.3810055268171195,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,DOWN,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.04,2.0879,-4.4654,-0.0583395233845751,1.1272819687196609e-08,Benign,0.0591,benign,-2.8,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T150C,NP_000537:p.Thr150Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15906,0.2275320887565612,0.37687,0.7794164396296868,0.10890499999999999,0.3101782198148434,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,DOWN,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.1664,2.0879,-22.2125,-2.3012366863889,0.0049915791095936,Benign,0.1784,benign,-3.305,available,https://doi.org/10.1101/2022.10.22.513328 +T150D,NP_000537:p.Thr150Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.27687,0.42592453956604,0.17551,0.3220030113848166,0.22619,0.2994365056924083,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,95.83,-,-0.163,2.0879,-5.9248,-1.44127999418459,6.484501307435367e-07,Benign,0.2075,benign,-3.126,available,https://doi.org/10.1101/2022.10.22.513328 +T150E,NP_000537:p.Thr150Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.38147,0.4210702180862427,-2.01701,0.0286088988727029,-1.19924,-0.17643055056364854,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.1273,2.0879,-3.7549,-1.46975084596866,4.4576088901927806e-08,Benign,0.1734,benign,-3.027,available,https://doi.org/10.1101/2022.10.22.513328 +T150F,NP_000537:p.Thr150Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.34134,0.3599094748497009,-0.10272,-0.5253619964372558,-0.72203,-0.9333509982186279,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.2378,2.0879,-22.2125,-2.94300550062853,0.0053734573450688,Benign,0.14,benign,-3.423,available,https://doi.org/10.1101/2022.10.22.513328 +T150G,NP_000537:p.Thr150Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.81922,1.422236680984497,1.80204,1.311084894514244,1.31063,1.0651524472571219,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,DOWN,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.1362,2.0879,-8.9247,-2.52309798408859,2.48702865458978e-05,Benign,0.1689,benign,-3.102,available,https://doi.org/10.1101/2022.10.22.513328 +T150H,NP_000537:p.Thr150His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.05549,0.3948396444320678,-0.52143,-0.2270312440906441,-0.28846,-0.14126062204532205,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.2181,2.0879,-22.2125,-3.26204842079165,0.0015876434830574,Benign,0.1355,benign,-3.274,available,https://doi.org/10.1101/2022.10.22.513328 +T150I,NP_000537:p.Thr150Ile,"hg19,17:g.7578481G>A, hg38,17:g.7675163G>A",,,0.381,"COSMIC,ClinVar,saturation_mutlist",1350373,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.02151,-0.1358811259269714,-0.8119,-0.6865130309906375,-0.9167049999999999,-0.8540115154953187,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.1564,2.0879,-22.2125,-3.1252856324116,0.0029552703372262,Benign,0.0817,benign,-3.418,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T150K,NP_000537:p.Thr150Lys,"hg38,17:g.7675163G>T",,,0.394,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.60486,0.9818837642669678,0.09354,0.279432073849587,-0.25566,-0.16271396307520647,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.1407,2.0879,-7.9247,-1.92414956095744,3.769194876056462e-05,Benign,0.1507,benign,-3.112,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T150L,NP_000537:p.Thr150Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.26806,-0.3209498524665832,-1.43537,-0.8348150142801275,-1.351715,-1.0514375071400637,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.1355,2.0879,-7.9247,-0.837289512398319,8.721763057193193e-08,Benign,0.0579,benign,-3.002,available,https://doi.org/10.1101/2022.10.22.513328 +T150M,NP_000537:p.Thr150Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.91875,-0.0456017851829528,-0.70204,-0.3608637932194636,-1.310395,-1.139806896609732,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.1024,2.0879,-7.9247,-1.81763674032839,8.166705578117588e-05,Benign,0.0712,benign,-3.186,available,https://doi.org/10.1101/2022.10.22.513328 +T150N,NP_000537:p.Thr150Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.04911,0.717881441116333,0.3585,0.1389552488668788,0.154695,0.0449226244334394,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,95.83,-,-0.0941,2.0879,-4.1699,-1.60949400738253,0.0003228007104106,Benign,0.0873,benign,-3.168,available,https://doi.org/10.1101/2022.10.22.513328 +T150P,NP_000537:p.Thr150Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.72821,0.4412887096405029,0.21293,1.0938753149770355,-0.25764,0.18283265748851774,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,95.83,-,-0.1854,2.0879,-0.7549,-0.0596061249256362,1.4246130708016462e-16,Benign,0.0473,benign,-2.674,available,https://doi.org/10.1101/2022.10.22.513328 +T150Q,NP_000537:p.Thr150Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.58243,0.4678038954734802,0.19728,0.1403600895415269,-0.192575,-0.22103495522923655,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.1125,2.0879,-5.9248,-1.20236455542424,1.0653459022365548e-06,Benign,0.1288,benign,-2.974,available,https://doi.org/10.1101/2022.10.22.513328 +T150R,NP_000537:p.Thr150Arg,"hg38,17:g.7675163G>C",,,0.441,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.1803,1.00886070728302,0.37177,-0.1041152989681659,-0.404265,-0.6422076494840829,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.2165,2.0879,-22.2125,-2.56508867935359,0.0006001931308391,Benign,0.123,benign,-3.143,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T150S,NP_000537:p.Thr150Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.21558,0.4228116869926452,0.1068,0.4745605468923386,0.16119,0.3450702734461693,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,neutral,neutral,potentially_damaging,DOWN,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.0065,2.0879,-5.0179,-1.18291027179086,1.6273476702270094e-07,Benign,0.0791,benign,-2.846,available,https://doi.org/10.1101/2022.10.22.513328 +T150V,NP_000537:p.Thr150Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.1384,0.1906619071960449,-0.08946,-0.4780117727620114,-0.11393,-0.3082058863810057,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.066,2.0879,-6.9248,-1.94571387094201,1.6237545491750614e-07,Benign,0.0733,benign,-3.015,available,https://doi.org/10.1101/2022.10.22.513328 +T150W,NP_000537:p.Thr150Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.81506,0.0611756443977355,0.03333,-0.7901501113630494,-0.390865,-0.8026050556815247,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.2307,2.0879,-22.2125,-3.461339694155,0.0037853430596953,Benign,0.3901,ambiguous,-3.545,available,https://doi.org/10.1101/2022.10.22.513328 +T150Y,NP_000537:p.Thr150Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.98242,0.2502784132957458,-0.52721,-0.3661154951362461,-0.754815,-0.674267747568123,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,,,Uncertain,,Uncertain,,,Uncertain,70.3,P,True,70.3,-0.081,uncertain,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,95.83,-,-0.2392,2.0879,-22.2125,-3.461339694155,0.0024173161784223,Benign,0.1817,benign,-3.44,available,https://doi.org/10.1101/2022.10.22.513328 +P151A,NP_000537:p.Pro151Ala,"hg19,17:g.7578479G>C, hg19,17:g.7675161G>C, hg38,17:g.7675161G>C",,,0.889,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376641,Pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.17768,1.7405389547348022,0.92109,-0.0402786838855473,2.049385,1.5687006580572265,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.3057,0.2371,-22.2096,-4.63399215214883,0.3922748470932101,Uncertain,0.6047,pathogenic,-3.65,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151C,NP_000537:p.Pro151Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.36632,1.2539808750152588,1.51429,0.3768019198839878,2.440305,1.871560959941994,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.75,-,-0.3384,0.2371,-22.2096,-6.16363153915127,0.8549852279033611,Pathogenic,0.9338,pathogenic,-4.065,available,https://doi.org/10.1101/2022.10.22.513328 +P151D,NP_000537:p.Pro151Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.02781,2.361362934112549,3.46088,1.9752126443216813,4.244345,3.5015113221608405,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.75,-,-0.3643,0.2371,-22.2096,-6.04162002975824,0.5194523335672228,Uncertain,0.9991,pathogenic,-4.27,available,https://doi.org/10.1101/2022.10.22.513328 +P151E,NP_000537:p.Pro151Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.00064,2.030780792236328,3.17857,1.7647379201945756,3.089605,2.382688960097288,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.3481,0.2371,-22.2096,-6.63561000906772,0.6378211624082941,Uncertain,0.9961,pathogenic,-4.249,available,https://doi.org/10.1101/2022.10.22.513328 +P151F,NP_000537:p.Pro151Phe,"hg19,17:g.7578478_7578479delinsAA, hg38,17:g.7675160_7675161delinsAA",,,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",824960,Likely pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.56048,1.2210216522216797,2.21973,0.0883618340174785,7.390105,6.324420917008739,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.3668,0.2371,-22.2096,-6.4931966516819,0.5886171425541176,Uncertain,0.9875,pathogenic,-4.129,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151G,NP_000537:p.Pro151Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.00995,2.109548330307007,2.26973,1.7509315194989572,3.63984,3.3804407597494786,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.3201,0.2371,-22.2096,-7.06411280791238,0.6840883236950395,Pathogenic,0.9777,pathogenic,-4.08,available,https://doi.org/10.1101/2022.10.22.513328 +P151H,NP_000537:p.Pro151His,"hg19,17:g.7578477_7578478delinsAT, hg19,17:g.7578478G>T, hg19,17:g.7675160G>T, hg38,17:g.7675159_7675160delinsAT, hg38,17:g.7675160G>T",,,0.870,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376639,Uncertain significance,1,Likely oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,8.70669,2.1672964096069336,3.56973,0.7448057964371024,6.13821,4.725747898218551,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.2766,0.2371,-8.9217,-6.83338577080362,0.777237693318333,Pathogenic,0.992,pathogenic,-4.273,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151I,NP_000537:p.Pro151Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.52249,1.710496187210083,2.5949,-0.2276517944589173,3.058695,1.6474191027705414,Uncertain,Uncertain,Uncertain,Destabilizing,Neutral,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.2821,0.2371,-8.9217,-4.13924626261262,0.2755533318288037,Benign,0.733,pathogenic,-3.946,available,https://doi.org/10.1101/2022.10.22.513328 +P151K,NP_000537:p.Pro151Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.391,2.2129950523376465,6.85068,2.6374033776641745,8.12084,6.014201688832087,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.3398,0.2371,-22.2096,-6.3532726475116,0.5063367787410941,Uncertain,0.9968,pathogenic,-4.22,available,https://doi.org/10.1101/2022.10.22.513328 +P151L,NP_000537:p.Pro151Leu,"hg19,17:g.7578478G>A, hg19,17:g.7675160G>A, hg38,17:g.7675159_7675160delinsAA, hg38,17:g.7675160G>A",,,0.771,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.17286,1.583258032798767,0.20442,-0.4521024134492046,1.18864,0.8603787932753977,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.2734,0.2371,-6.3369,-3.56420144651336,0.0001429264660025,Benign,0.5469,ambiguous,-3.346,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151M,NP_000537:p.Pro151Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.63506,1.6827337741851809,1.02449,0.0419771115112399,2.829775,2.33851855575562,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.3054,0.2371,-22.2096,-5.56005426138843,0.4024047053152033,Uncertain,0.9153,pathogenic,-3.956,available,https://doi.org/10.1101/2022.10.22.513328 +P151N,NP_000537:p.Pro151Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.41771,2.2906551361083984,1.94524,0.5806421821771182,2.681475,1.9991760910885592,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.75,-,-0.3324,0.2371,-22.2096,-5.98155647386477,0.6995185679855449,Pathogenic,0.9971,pathogenic,-4.08,available,https://doi.org/10.1101/2022.10.22.513328 +P151Q,NP_000537:p.Pro151Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.57033,2.256746292114258,2.31973,0.7827021815290353,3.44503,2.6765160907645176,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.3341,0.2371,-22.2096,-6.63561000906772,0.5956876763329336,Uncertain,0.9907,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328 +P151R,NP_000537:p.Pro151Arg,"hg19,17:g.7578478G>C, hg19,17:g.7675160G>C, hg38,17:g.7675160G>C",,,0.912,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376640,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.95465,2.284924030303955,4.68061,1.5077298412634672,7.31763,5.731189920631734,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.3755,0.2371,-22.2096,-6.73559736215129,0.8632261666675214,Pathogenic,0.9897,pathogenic,-4.315,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151S,NP_000537:p.Pro151Ser,"hg19,17:g.7578478_7578479delinsCT, hg19,17:g.7578479G>A, hg19,17:g.7578479_7578480delinsAA, hg19,17:g.7675161G>A, hg38,17:g.7675160_7675161delinsCT, hg38,17:g.7675161G>A",,,0.898,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2700111, 12370","Pathogenic, Pathogenic/Likely pathogenic","1, 2",,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,4.05396,2.0886034965515137,1.90102,0.8926362936107635,2.97749,2.473298146805382,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.2325,0.2371,-7.9218,-4.23585533397574,0.342498808788838,Uncertain,0.961,pathogenic,-3.755,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151T,NP_000537:p.Pro151Thr,"hg19,17:g.7578479G>T, hg19,17:g.7675161G>T, hg38,17:g.7675161G>T",,,0.911,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12369,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.33702,2.158976793289185,0.55238,0.2948431741496149,1.9446999999999999,1.8159315870748074,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.75,-,-0.2497,0.2371,-8.9217,-5.74914592533455,0.332737805680815,Uncertain,0.8944,pathogenic,-3.691,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P151V,NP_000537:p.Pro151Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.03322,1.8919579982757568,0.10136,-0.5215103042328884,1.06729,0.7558548478835558,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.2323,0.2371,-7.9218,-4.01796100280007,0.2030272121211438,Benign,0.587,pathogenic,-3.659,available,https://doi.org/10.1101/2022.10.22.513328 +P151W,NP_000537:p.Pro151Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,18.29764,1.8566389083862305,7.59898,1.1064833804336949,12.948310000000001,9.702061690216848,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.3793,0.2371,-22.2096,-6.83338577080362,0.8706225980560897,Pathogenic,0.998,pathogenic,-4.524,available,https://doi.org/10.1101/2022.10.22.513328 +P151Y,NP_000537:p.Pro151Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,14.9315,1.4854588508605957,3.27857,0.8103585612109379,9.105035,7.870929280605469,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.014,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.75,-,-0.3678,0.2371,-22.2096,-6.47872592104193,0.6212405679009481,Uncertain,0.9965,pathogenic,-4.27,available,https://doi.org/10.1101/2022.10.22.513328 +P152A,NP_000537:p.Pro152Ala,"hg38,17:g.7675158G>C",,,0.803,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.46518,1.3395497798919678,1.47449,0.2577871614753496,1.9698350000000002,1.3614835807376748,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.44,-,-0.3216,0.0642,-22.2096,-5.61534998839996,0.4881995273608804,Uncertain,0.3011,benign,-3.685,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152C,NP_000537:p.Pro152Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.36451,1.0768723487854004,2.47925,0.9500049370763356,2.42188,1.6572574685381678,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.44,-,-0.3543,0.0642,-22.2096,-6.34524994707572,0.7823151535316585,Pathogenic,0.8229,pathogenic,-4.168,available,https://doi.org/10.1101/2022.10.22.513328 +P152D,NP_000537:p.Pro152Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.96318,1.3913187980651855,1.57415,0.1848173604377284,1.768665,1.0739986802188641,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.44,-,-0.3802,0.0642,-22.2096,-6.31870877375324,0.3979095024570115,Uncertain,0.9006,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +P152E,NP_000537:p.Pro152Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.54909,1.4442713260650637,1.63741,0.0625891571371878,1.59325,0.8058395785685939,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.44,-,-0.2962,0.0642,-8.9217,-6.19005314131496,0.0917633181737498,Benign,0.7486,pathogenic,-3.812,available,https://doi.org/10.1101/2022.10.22.513328 +P152F,NP_000537:p.Pro152Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.26069,1.5583271980285645,1.95612,0.0798527567721141,2.108405,1.170271378386057,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.44,-,-0.3827,0.0642,-22.2096,-6.97284644458033,0.8463963320576667,Pathogenic,0.8822,pathogenic,-4.112,available,https://doi.org/10.1101/2022.10.22.513328 +P152G,NP_000537:p.Pro152Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.73774,1.7404506206512451,1.71054,0.7847455754062255,2.2241400000000002,1.7612427877031127,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.44,-,-0.336,0.0642,-22.2096,-7.61017213781414,0.7625043073916675,Pathogenic,0.698,pathogenic,-3.908,available,https://doi.org/10.1101/2022.10.22.513328 +P152H,NP_000537:p.Pro152His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.49757,1.642292857170105,1.57041,-0.1490351284907665,2.03399,1.1742674357546168,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.44,-,-0.2925,0.0642,-8.9217,-6.85045828881582,0.167658588089582,Benign,0.6865,pathogenic,-3.826,available,https://doi.org/10.1101/2022.10.22.513328 +P152I,NP_000537:p.Pro152Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.9184,1.6452698707580566,3.2949,0.156471650640983,2.60665,1.0374358253204916,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.44,-,-0.3658,0.0642,-22.2096,-6.0987285320018,0.4066861299350841,Uncertain,0.7032,pathogenic,-3.957,available,https://doi.org/10.1101/2022.10.22.513328 +P152K,NP_000537:p.Pro152Lys,"hg19,17:g.7578475_7578476delinsTT, hg38,17:g.7675157_7675158delinsTT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.58552,1.5986003875732422,1.52449,0.028872178437872,1.555005,0.807196089218936,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.44,-,-0.3557,0.0642,-22.2096,-7.28055381223327,0.7691636867311082,Pathogenic,0.7899,pathogenic,-4.206,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152L,NP_000537:p.Pro152Leu,"hg19,17:g.7578475G>A, hg19,17:g.7578475_7578476delinsAA, hg19,17:g.7675157G>A, hg38,17:g.7675157G>A, hg38,17:g.7675157_7675158delinsAA",,7.9594387004e-06,0.878,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142766,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.31947,1.443366527557373,0.92891,-0.1770700687507204,1.12419,0.5711999656246398,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.44,-,-0.3026,0.0642,-8.9217,-4.24497340682494,0.0987159823410947,Benign,0.3559,ambiguous,-3.698,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152M,NP_000537:p.Pro152Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.21786,1.461397647857666,1.72245,0.0421161617451759,1.470155,0.629988080872588,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.44,-,-0.3213,0.0642,-22.2096,-5.82982202233048,0.7007870610599661,Pathogenic,0.7186,pathogenic,-3.944,available,https://doi.org/10.1101/2022.10.22.513328 +P152N,NP_000537:p.Pro152Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.32661,1.545548439025879,0.58435,0.1437945277141394,1.45548,1.2352022638570697,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.44,-,-0.3484,0.0642,-22.2096,-6.00049827692235,0.4872572343487852,Uncertain,0.8625,pathogenic,-3.965,available,https://doi.org/10.1101/2022.10.22.513328 +P152Q,NP_000537:p.Pro152Gln,"hg19,17:g.7578475G>T, hg19,17:g.7675157G>T, hg38,17:g.7675157G>T",,,0.843,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1058730,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.09415,1.5060977935791016,1.62415,0.2570859723771523,1.85915,1.175617986188576,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.44,-,-0.35,0.0642,-22.2096,-5.21034163519331,0.355603825326182,Uncertain,0.5994,pathogenic,-3.7,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152R,NP_000537:p.Pro152Arg,"hg19,17:g.7578475G>C, hg19,17:g.7675157G>C, hg38,17:g.7675157G>C",,,0.853,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",824998,Pathogenic/Likely pathogenic,2,,,Tier II - Potential,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.42753,1.694346308708191,1.16871,-0.0963182562554654,1.29812,0.6656058718722673,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.44,-,-0.3914,0.0642,-22.2096,-7.52848769412826,0.7960856561445921,Pathogenic,0.6385,pathogenic,-4.184,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152S,NP_000537:p.Pro152Ser,"hg19,17:g.7578476G>A, hg19,17:g.7675158G>A, hg38,17:g.7675158G>A",,3.9791175909e-06,0.863,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",482230,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.73687,1.3678793907165527,1.91395,0.3293357893038257,2.32541,1.533102894651913,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.44,-,-0.3213,0.0642,-22.2096,-5.6228131894386,0.5117945789926174,Uncertain,0.4796,ambiguous,-3.712,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152T,NP_000537:p.Pro152Thr,"hg19,17:g.7578476G>T, hg38,17:g.7675158G>T",,,0.866,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2687709,Uncertain significance,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.24013,1.704279541969299,1.81429,0.4101083568192265,2.52721,1.8251191784096132,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.44,-,-0.3335,0.0642,-22.2096,-5.99199484505145,0.0946032624124289,Benign,0.4973,ambiguous,-3.762,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P152V,NP_000537:p.Pro152Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.33652,1.7568342685699463,1.77007,0.2117774065716299,2.0532950000000003,1.274148703285815,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.44,-,-0.3212,0.0642,-22.2096,-5.93961873685791,0.4630593926742973,Uncertain,0.5521,ambiguous,-3.814,available,https://doi.org/10.1101/2022.10.22.513328 +P152W,NP_000537:p.Pro152Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.29849,1.6475119590759275,1.83027,-0.3139639475967404,2.06438,0.9922630262016299,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.44,-,-0.3953,0.0642,-22.2096,-7.20207466639269,0.7975974424294667,Pathogenic,0.9495,pathogenic,-4.403,available,https://doi.org/10.1101/2022.10.22.513328 +P152Y,NP_000537:p.Pro152Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.26069,1.5113525390625,1.79694,0.080632177908137,2.028815,1.1706610889540685,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,49.8,,True,49.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.44,-,-0.3837,0.0642,-22.2096,-7.20207466639269,0.6590475960225636,Uncertain,0.8867,pathogenic,-4.162,available,https://doi.org/10.1101/2022.10.22.513328 +P153A,NP_000537:p.Pro153Ala,"hg19,17:g.7578473G>C, hg38,17:g.7675155G>C",,,0.369,"COSMIC,ClinVar,saturation_mutlist",2687700,Uncertain significance,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.94448,0.169689655303955,1.13061,0.0187599504912705,1.037545,0.48161997524563527,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.0671,1.8236,-4.0639,-0.874315076869635,2.249786532269203e-07,Benign,0.0565,benign,-3.029,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P153C,NP_000537:p.Pro153Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.16111,0.2744483351707458,2.00578,0.7419027983488948,1.5834450000000002,0.9515063991744475,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.11,T,-0.1246,1.8236,-8.9217,-3.37086280585557,0.0453353286221627,Benign,0.2572,benign,-3.718,available,https://doi.org/10.1101/2022.10.22.513328 +P153D,NP_000537:p.Pro153Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.05814,0.3269031047821045,0.79048,-0.2751649054150856,0.92431,0.39148754729245727,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.11,T,-0.2183,1.8236,-22.2096,-2.32569864445034,0.0326449822076869,Benign,0.2563,benign,-3.528,available,https://doi.org/10.1101/2022.10.22.513328 +P153E,NP_000537:p.Pro153Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.68324,0.1457156538963318,0.88197,-0.4310264196175478,0.782605,0.1261067901912261,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.11,T,-0.2021,1.8236,-22.2096,-2.18010110490429,0.0088438823980619,Benign,0.1445,benign,-3.398,available,https://doi.org/10.1101/2022.10.22.513328 +P153F,NP_000537:p.Pro153Phe,"hg38,17:g.7675154_7675155delinsAA",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.98823,0.633732259273529,1.52755,-0.141554940728531,1.25789,0.4233375296357345,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.11,T,-0.2208,1.8236,-22.2096,-1.24668585809957,0.1578705838212771,Benign,0.2715,benign,-3.702,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P153G,NP_000537:p.Pro153Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.23406,0.6819962859153748,1.72007,0.4739608440076376,1.477065,0.8540104220038187,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.1741,1.8236,-22.2096,-3.95116626630119,0.0007385346702957,Benign,0.2054,benign,-3.628,available,https://doi.org/10.1101/2022.10.22.513328 +P153H,NP_000537:p.Pro153His,"hg19,17:g.7578472G>T, hg38,17:g.7675154G>T",,,0.391,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.10498,0.4345605373382568,1.35918,-0.361427739837008,1.23208,0.371776130081496,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.11,T,-0.1163,1.8236,-6.1145,-1.71797211950995,0.0018338198631235,Benign,0.1129,benign,-3.326,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P153I,NP_000537:p.Pro153Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.20275,0.4947582483291626,1.7017,-0.0552846747094931,1.4522249999999999,0.5737326626452535,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.11,T,-0.2039,1.8236,-22.2096,-2.97840143274698,0.2020382289582234,Benign,0.1665,benign,-3.62,available,https://doi.org/10.1101/2022.10.22.513328 +P153K,NP_000537:p.Pro153Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.01598,0.4552875161170959,1.07109,-0.2294082197958763,1.043535,0.3932858901020619,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.11,T,-0.1209,1.8236,-7.9218,-2.60138236025987,0.0041695979268936,Benign,0.1727,benign,-3.443,available,https://doi.org/10.1101/2022.10.22.513328 +P153L,NP_000537:p.Pro153Leu,"hg19,17:g.7578472G>A, hg38,17:g.7675154G>A",,,0.370,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",645432,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.07881,0.5195014476776123,1.4085,-0.3587898926200222,1.243655,0.36001005368998895,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.11,T,-0.1182,1.8236,-4.5295,-1.05022549185284,5.174614441888086e-06,Benign,0.0741,benign,-3.076,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P153M,NP_000537:p.Pro153Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.98659,0.5452861785888672,1.84422,-0.0418583940258526,1.415405,0.4723658029870737,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.11,T,-0.0814,1.8236,-6.9218,-1.97094944864724,0.0001097600894624,Benign,0.1725,benign,-3.308,available,https://doi.org/10.1101/2022.10.22.513328 +P153N,NP_000537:p.Pro153Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.18627,0.5691372156143188,1.20646,-0.0110913951356417,1.1963650000000001,0.5875893024321791,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.11,T,-0.1865,1.8236,-22.2096,-1.72835991884289,0.0302591926167483,Benign,0.1908,benign,-3.581,available,https://doi.org/10.1101/2022.10.22.513328 +P153Q,NP_000537:p.Pro153Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.10297,0.3325128555297851,1.31395,0.028188661582168,1.20846,0.565579330791084,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.11,T,-0.08,1.8236,-1.021,-0.384785883446999,7.423362940393784e-05,Benign,0.0872,benign,-3.087,available,https://doi.org/10.1101/2022.10.22.513328 +P153R,NP_000537:p.Pro153Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.96606,0.5505784153938293,1.54558,-0.2373064909697009,1.25582,0.36437675451514956,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.11,T,-0.1537,1.8236,-7.3368,-0.956192601333636,0.0022283586598844,Benign,0.0975,benign,-3.478,available,https://doi.org/10.1101/2022.10.22.513328 +P153S,NP_000537:p.Pro153Ser,"hg19,17:g.7578473G>A, hg38,17:g.7675155G>A",,,0.359,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",422563,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.10831,0.2707995176315307,1.05918,-0.0645815185607112,1.083745,0.5218642407196443,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.0835,1.8236,-7.3368,-2.15873427907793,0.0003502422905545,Benign,0.0929,benign,-3.192,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P153T,NP_000537:p.Pro153Thr,"hg38,17:g.7675155G>T",,,0.382,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.0205,0.5463980436325073,1.2466,0.0216956953628411,1.13355,0.5210978476814205,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.11,T,-0.0957,1.8236,-7.3368,-1.49432397380345,0.00257968891441,Benign,0.0862,benign,-3.471,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P153V,NP_000537:p.Pro153Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.02965,0.5275819301605225,1.67381,0.0673511810881438,1.3517299999999999,0.5485005905440719,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.11,T,-0.0915,1.8236,-8.9217,-1.49025938301281,0.0009013492003504,Benign,0.1116,benign,-3.41,available,https://doi.org/10.1101/2022.10.22.513328 +P153W,NP_000537:p.Pro153Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.96231,0.5734381079673767,1.64796,-0.6006124643472877,1.305135,0.18084876782635617,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.11,T,-0.2334,1.8236,-22.2096,-3.25959204981253,0.5377588861213921,Uncertain,0.3747,ambiguous,-4.002,available,https://doi.org/10.1101/2022.10.22.513328 +P153Y,NP_000537:p.Pro153Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.9997,0.5350218415260315,1.3102,-0.0978310289094325,1.15495,0.45093448554528376,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.004,,,Uncertain,,Uncertain,,,Uncertain,98.6,,False,98.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.11,T,-0.2218,1.8236,-22.2096,-3.25959204981253,0.2359348155010482,Benign,0.2758,benign,-3.86,available,https://doi.org/10.1101/2022.10.22.513328 +G154A,NP_000537:p.Gly154Ala,"hg19,17:g.7578469C>G, hg38,17:g.7675151C>G",,,0.728,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2840669,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.00961,1.288464903831482,1.7568,1.959213905345839,2.8832050000000002,2.98441195267292,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.3571,0.2867,-22.2096,-4.06697645914284,0.0048197395846311,Benign,0.2768,benign,-3.708,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154C,NP_000537:p.Gly154Cys,"hg19,17:g.7578470C>A, hg38,17:g.7675152C>A",,,0.715,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1741887,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.90679,0.6247493028640747,2.38435,2.067285332044864,2.64557,2.487037666022432,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.3491,0.2867,-8.9217,-4.08463118414522,0.7262429897836769,Pathogenic,0.3408,ambiguous,-4.008,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154D,NP_000537:p.Gly154Asp,"hg19,17:g.7578468_7578469delinsAT, hg19,17:g.7578469C>T, hg38,17:g.7675150_7675151delinsAT, hg38,17:g.7675151C>T",,7.9595020536e-06,0.721,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2687710, 237950","Uncertain significance, Uncertain significance","0, 3",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.16682,1.0529999732971191,1.03299,1.0576717693505555,2.599905,2.612245884675278,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.3415,0.2867,-7.3368,-1.7982562863318,0.0048849083524315,Benign,0.261,benign,-3.496,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154E,NP_000537:p.Gly154Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.7844,1.241879940032959,1.38095,1.4554490535158793,2.582675,2.6199245267579396,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.4167,0.2867,-22.2096,-5.5249117406559,0.4687762801003565,Uncertain,0.3976,ambiguous,-3.74,available,https://doi.org/10.1101/2022.10.22.513328 +G154F,NP_000537:p.Gly154Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.8212,1.051745891571045,1.46293,1.367740734003966,2.642065,2.594470367001983,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.455,0.2867,-22.2096,-6.2525132521354,0.5858204996671974,Uncertain,0.6849,pathogenic,-4.115,available,https://doi.org/10.1101/2022.10.22.513328 +G154H,NP_000537:p.Gly154His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.15983,1.1525864601135254,0.80918,0.9740853862935072,2.4845050000000004,2.5669576931467537,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.4297,0.2867,-22.2096,-2.76642961177661,0.2059169021416705,Benign,0.479,ambiguous,-3.839,available,https://doi.org/10.1101/2022.10.22.513328 +G154I,NP_000537:p.Gly154Ile,"hg19,17:g.7578469_7578470delinsAT, hg38,17:g.7675151_7675152delinsAT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.46721,1.5352675914764404,5.92619,2.9640533095418977,6.1967,4.715631654770949,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.5007,0.2867,-22.2096,-6.63131476926816,0.824655192806746,Pathogenic,0.7892,pathogenic,-4.296,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154K,NP_000537:p.Gly154Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.66815,1.3818845748901367,-1.00918,1.178114313201535,1.329485,2.4231321566007673,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.4496,0.2867,-22.2096,-5.36388597125634,0.1566504546564236,Benign,0.7454,pathogenic,-3.793,available,https://doi.org/10.1101/2022.10.22.513328 +G154L,NP_000537:p.Gly154Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.94477,1.2339781522750854,1.69218,1.3657290970870712,2.8184750000000003,2.6552495485435355,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.4689,0.2867,-22.2096,-6.29531104381167,0.5919993205407742,Uncertain,0.6683,pathogenic,-3.999,available,https://doi.org/10.1101/2022.10.22.513328 +G154M,NP_000537:p.Gly154Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.68699,1.2180545330047607,1.9932,1.3384448957378885,2.8400950000000003,2.5127174478689445,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.4071,0.2867,-22.2096,-6.63131476926816,0.7870712756526672,Pathogenic,0.6961,pathogenic,-4.139,available,https://doi.org/10.1101/2022.10.22.513328 +G154N,NP_000537:p.Gly154Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.98685,0.9902112483978271,0.83469,0.583719046174524,1.91077,1.785284523087262,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.3397,0.2867,-6.9218,-1.81209055051064,0.0095337485631653,Benign,0.2439,benign,-3.436,available,https://doi.org/10.1101/2022.10.22.513328 +G154P,NP_000537:p.Gly154Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.01167,1.7638801336288452,20.16667,6.744271772729575,13.08917,6.377970886364787,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.5148,0.2867,-22.2096,-5.79795393822105,0.0258027473354065,Benign,0.94,pathogenic,-3.802,available,https://doi.org/10.1101/2022.10.22.513328 +G154Q,NP_000537:p.Gly154Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.56748,1.3649615049362185,1.52925,1.4132805800211934,2.548365,2.490380290010597,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.4206,0.2867,-22.2096,-4.56866968611123,0.1354306687201455,Benign,0.4827,ambiguous,-3.738,available,https://doi.org/10.1101/2022.10.22.513328 +G154R,NP_000537:p.Gly154Arg,"hg19,17:g.7578470C>G, hg38,17:g.7675152C>G",,,0.711,"COSMIC,ClinVar,saturation_mutlist",482229,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.25735,1.4089783430099487,1.8017,1.088117290912442,2.529525,2.172733645456221,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.4337,0.2867,-22.2096,-5.51523440597117,0.051699364391038,Benign,0.5843,pathogenic,-3.662,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154S,NP_000537:p.Gly154Ser,"hg19,17:g.7578470C>T, hg19,17:g.7675152C>T, hg38,17:g.7675152C>T",0.0001593371574251,3.9800678204e-06,0.638,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",133284,Uncertain significance,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,4.42105,1.2935676574707031,1.6051,1.663816804354398,3.013075,3.042433402177199,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.2799,0.2867,-5.9218,-2.15790889825012,8.703142915299439e-06,Benign,0.1525,benign,-3.21,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154T,NP_000537:p.Gly154Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.32145,1.479990839958191,3.34558,2.3669567979848174,4.833515,4.344203398992408,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.4399,0.2867,-22.2096,-5.6807562113225,0.4636622333212558,Uncertain,0.3805,ambiguous,-3.851,available,https://doi.org/10.1101/2022.10.22.513328 +G154V,NP_000537:p.Gly154Val,"hg19,17:g.7578468_7578469delinsAA, hg19,17:g.7578469C>A, hg19,17:g.7675150_7675151delinsAA, hg19,17:g.7675151C>A, hg38,17:g.7675151C>A",,,0.754,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",651769,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.66715,1.6232385635375977,5.38435,2.794378373574236,5.52575,4.230764186787118,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.4439,0.2867,-22.2096,-6.63131476926816,0.5039223527564188,Uncertain,0.5817,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G154W,NP_000537:p.Gly154Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.98782,1.2582333087921145,1.83844,1.0505696019523338,2.91313,2.519194800976167,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.387,0.2867,-8.9217,-4.4684824170351,0.0020514383442931,Benign,0.6447,pathogenic,-3.978,available,https://doi.org/10.1101/2022.10.22.513328 +G154Y,NP_000537:p.Gly154Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.85016,1.1793601512908936,1.36463,1.3640841264209735,2.607395,2.6071220632104866,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,93.9,,False,93.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.41,T,-0.4554,0.2867,-22.2096,-6.2525132521354,0.7516188939142655,Pathogenic,0.5469,ambiguous,-4.181,available,https://doi.org/10.1101/2022.10.22.513328 +T155A,NP_000537:p.Thr155Ala,"hg19,17:g.7578467T>C, hg38,17:g.7675149T>C",,7.9589319113e-06,0.337,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458544,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.63016,1.684255599975586,0.49728,0.6596779797990304,1.06372,1.1449189898995153,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,damaging,uncertain,DOWN,neutral,neutral,False,neutral,neutral,98.18,-,-0.0844,1.4012,-0.7926,-0.502175641617173,5.17365220891069e-10,Benign,0.086,benign,-2.922,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155C,NP_000537:p.Thr155Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.33406,1.4245948791503906,0.29864,0.904357019015424,0.81635,1.119208509507712,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,damaging,uncertain,DOWN,neutral,neutral,False,neutral,neutral,98.18,-,-0.1617,1.4012,-8.9217,-2.12783777709344,0.0002307191847469,Benign,0.2118,benign,-3.298,available,https://doi.org/10.1101/2022.10.22.513328 +T155D,NP_000537:p.Thr155Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.45382,3.093404769897461,3.73095,2.874732815983552,4.092385,3.6642764079917765,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,neutral,uncertain,-,uncertain,neutral,False,neutral,neutral,98.18,-,-0.3093,1.4012,-22.2096,-5.25779070973747,0.43338854297156,Uncertain,0.9629,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328 +T155E,NP_000537:p.Thr155Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.52419,3.169856548309326,5.41803,3.053091256260343,4.9711099999999995,3.7886406281301714,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,98.18,-,-0.2846,1.4012,-22.2096,-5.25779070973747,0.6595253329014732,Uncertain,0.9695,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +T155F,NP_000537:p.Thr155Phe,"hg19,17:g.7578466_7578467delinsAA",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.15281,1.8150666952133176,7.90578,3.0348388826194865,8.029295000000001,5.593824441309744,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,98.18,-,-0.301,1.4012,-22.2096,-4.17937261647989,0.0084138522792774,Benign,0.8902,pathogenic,-3.608,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155G,NP_000537:p.Thr155Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.57811,2.56713342666626,2.91259,2.747742883631956,3.24535,3.162926441815978,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,neutral,uncertain,DOWN,neutral,neutral,False,neutral,neutral,98.18,-,-0.1994,1.4012,-8.9217,-3.6640752121291,0.6432123765778344,Uncertain,0.3793,ambiguous,-3.866,available,https://doi.org/10.1101/2022.10.22.513328 +T155H,NP_000537:p.Thr155His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.83999,2.6550118923187256,5.72483,3.348746770006694,7.7824100000000005,6.594368385003348,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,98.18,-,-0.2813,1.4012,-22.2096,-4.89973092444482,0.2478314655462414,Benign,0.8989,pathogenic,-3.82,available,https://doi.org/10.1101/2022.10.22.513328 +T155I,NP_000537:p.Thr155Ile,"hg19,17:g.7578466G>A, hg19,17:g.7675148G>A, hg38,17:g.7675148G>A",,,0.597,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1005876,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.41232,1.511465311050415,2.90952,0.1501123754147187,2.16092,0.7812161877073593,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.18,-,-0.2196,1.4012,-22.2096,-4.0458363280804,0.0970850981108774,Benign,0.833,pathogenic,-3.74,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155K,NP_000537:p.Thr155Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.26314,3.211361885070801,2.99796,5.556989713898483,4.1305499999999995,5.4100648569492416,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,98.18,-,-0.2768,1.4012,-22.2096,-5.80513631646375,0.5115064373436632,Uncertain,0.974,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328 +T155L,NP_000537:p.Thr155Leu,"hg38,17:g.7675147_7675149delinsAAG",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.01269,1.851534485816956,5.41939,0.6399025020922222,3.71604,1.3262962510461112,Uncertain,Uncertain,Uncertain,Destabilizing,Neutral,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,uncertain,uncertain,UP,neutral,neutral,False,neutral,neutral,98.18,-,-0.2716,1.4012,-22.2096,-3.85120811517604,0.0077627384209902,Benign,0.581,pathogenic,-3.426,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155M,NP_000537:p.Thr155Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.11918,1.80846107006073,1.57449,1.3742285768848803,1.846835,1.7467042884424402,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,uncertain,uncertain,UP,neutral,neutral,False,neutral,neutral,98.18,-,-0.2385,1.4012,-22.2096,-4.35519053423558,0.270420382624247,Benign,0.4361,ambiguous,-3.558,available,https://doi.org/10.1101/2022.10.22.513328 +T155N,NP_000537:p.Thr155Asn,"hg19,17:g.7578466G>C, hg19,17:g.7578466G>T, hg19,17:g.7675148G>T, hg38,17:g.7675148G>T",3.18775900542e-05,,0.548,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406564,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,4.86568,2.631312847137451,2.90476,1.4095893636369476,3.8852200000000003,3.137634681818474,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,neutral,uncertain,-,uncertain,neutral,False,neutral,neutral,98.18,-,-0.2493,1.4012,-22.2096,-4.96926233526373,0.6662515345562836,Uncertain,0.7722,pathogenic,-3.902,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155P,NP_000537:p.Thr155Pro,"hg19,17:g.7578467T>G, hg19,17:g.7675149T>G, hg38,17:g.7675149T>G",,,0.581,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2768025,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.44372,2.918423652648926,5.53061,5.060156574477813,3.987165,3.7519382872389064,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,uncertain,uncertain,-,uncertain,neutral,False,neutral,neutral,98.18,-,-0.358,1.4012,-22.2096,-5.80513631646375,0.5827820910167374,Uncertain,0.9028,pathogenic,-3.827,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155Q,NP_000537:p.Thr155Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.47021,2.812098264694214,2.39218,2.1845833807077395,3.4311949999999998,3.3273966903538694,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,98.18,-,-0.2588,1.4012,-22.2096,-5.25779070973747,0.4677811848233746,Uncertain,0.9165,pathogenic,-3.924,available,https://doi.org/10.1101/2022.10.22.513328 +T155R,NP_000537:p.Thr155Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.82348,2.894357442855835,2.54048,4.597492661449987,4.18198,5.210486330724994,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,98.18,-,-0.2796,1.4012,-22.2096,-5.80513631646375,0.5146723951322584,Uncertain,0.9479,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +T155S,NP_000537:p.Thr155Ser,"hg19,17:g.7578466G>C, hg38,17:g.7675148G>C, hg38,17:g.7675149T>A",3.18775900542e-05,,"0.359, 0.424","cBioPortal,COSMIC,ClinVar,saturation_mutlist",186179,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.85333,0.9098449945449828,1.6034,1.6367293432754575,1.728365,1.7450296716377287,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,neutral,damaging,uncertain,DOWN,neutral,neutral,False,neutral,neutral,98.18,-,-0.0588,1.4012,-2.8775,-0.0793354338503833,1.381761769595731e-10,Benign,0.0875,benign,-2.882,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T155V,NP_000537:p.Thr155Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.53294,1.4463831186294556,0.7381,-0.3701075738650994,0.63552,0.08141621306745028,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.18,-,-0.2072,1.4012,-22.2096,-4.11351162520015,0.0237703039281077,Benign,0.517,ambiguous,-3.446,available,https://doi.org/10.1101/2022.10.22.513328 +T155W,NP_000537:p.Thr155Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,19.00188,2.0651965141296387,17.11088,5.2639354658241615,18.05638,12.13290773291208,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,98.18,-,-0.2939,1.4012,-22.2096,-4.89973092444482,0.7255516461548432,Pathogenic,0.9699,pathogenic,-4.034,available,https://doi.org/10.1101/2022.10.22.513328 +T155Y,NP_000537:p.Thr155Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,11.77467,1.992136120796204,9.57007,4.3459612013692,10.67237,8.0603156006846,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.019,,,,,,,,,1.2,P,False,1.2,13.536,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,98.18,-,-0.3024,1.4012,-22.2096,-4.52348740602341,0.0277192915295778,Benign,0.9178,pathogenic,-3.77,available,https://doi.org/10.1101/2022.10.22.513328 +R156A,NP_000537:p.Arg156Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.6765,1.7929835319519043,1.08027,1.3367044966495445,0.878385,1.0066022483247723,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.1423,1.8853,-3.7926,-1.75738707360167,0.0018230464683667,Benign,0.6224,pathogenic,-3.322,available,https://doi.org/10.1101/2022.10.22.513328 +R156C,NP_000537:p.Arg156Cys,"hg19,17:g.7578464G>A, hg19,17:g.7675146G>A, hg38,17:g.7675146G>A",,3.9795926489e-06,0.493,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127810,Conflicting classifications of pathogenicity,1,,,Tier II - Potential,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.42422,0.9157652854919434,1.20952,1.7546541483037852,0.81687,1.0894370741518926,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.1596,1.8853,-5.4624,-0.336239047499407,1.8857099437031558e-07,Benign,0.1809,benign,-3.093,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R156D,NP_000537:p.Arg156Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.06395,2.9764280319213867,2.77279,2.196647208553862,2.4183700000000004,2.1302986042769314,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.3273,1.8853,-22.2096,-3.99777403960999,0.0416513387702734,Benign,0.9323,pathogenic,-3.954,available,https://doi.org/10.1101/2022.10.22.513328 +R156E,NP_000537:p.Arg156Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.76612,2.469135999679565,1.6,1.844872107026116,1.18306,1.305496053513058,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.2725,1.8853,-22.2096,-3.99777403960999,0.0234122196083114,Benign,0.6494,pathogenic,-3.656,available,https://doi.org/10.1101/2022.10.22.513328 +R156F,NP_000537:p.Arg156Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.46384,0.8556498289108276,-0.51803,0.3352326943494599,-0.990935,-0.5643036528252701,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.07,E,-0.1925,1.8853,-7.3368,-1.95874375949082,5.2824297054384814e-05,Benign,0.5958,pathogenic,-3.321,available,https://doi.org/10.1101/2022.10.22.513328 +R156G,NP_000537:p.Arg156Gly,"hg19,17:g.7578464G>C, hg19,17:g.7675146G>C, hg38,17:g.7675146G>C",,,0.580,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1517870,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.64932,2.3563907146453857,2.35204,2.4561937570579886,2.00068,2.052756878528994,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.2716,1.8853,-22.2096,-2.72461497518018,0.029281218090832,Benign,0.6544,pathogenic,-3.652,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R156H,NP_000537:p.Arg156His,"hg19,17:g.7578463C>T, hg19,17:g.7675145C>T, hg38,17:g.7675145C>T",,1.59192575258e-05,0.627,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127811,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.06565,1.3272018432617188,0.2585,0.9246029213914484,0.09642500000000001,0.4294764606957242,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.1382,1.8853,-8.9217,-1.69809690112553,0.000146432999198,Benign,0.1586,benign,-3.206,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R156I,NP_000537:p.Arg156Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.7948,1.2295844554901123,0.07823,0.47949650578686,-0.35828499999999996,-0.15765174710656998,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.1702,1.8853,-3.4956,-0.789150660647624,6.029404715997523e-08,Benign,0.3879,ambiguous,-3.026,available,https://doi.org/10.1101/2022.10.22.513328 +R156K,NP_000537:p.Arg156Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15622,0.6427736282348633,0.56293,1.226115370566313,0.203355,0.5349476852831565,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.07,E,-0.1265,1.8853,-22.2096,-2.63040850174089,0.0343168503203364,Benign,0.18,benign,-3.268,available,https://doi.org/10.1101/2022.10.22.513328 +R156L,NP_000537:p.Arg156Leu,"hg19,17:g.7578463C>A, hg38,17:g.7675145C>A",,,0.512,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.15866,0.8174647092819214,0.23776,0.2458579309304076,-0.46045,-0.4564010345347962,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.1539,1.8853,-5.5999,-0.83890271459001,2.1034771397284842e-08,Benign,0.3339,benign,-3.058,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R156M,NP_000537:p.Arg156Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.20609,0.7500439882278442,0.14422,0.7545236305918698,-0.530935,-0.22578318470406517,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.1206,1.8853,-5.7519,-0.862060368096797,7.089547537643953e-07,Benign,0.4523,ambiguous,-3.16,available,https://doi.org/10.1101/2022.10.22.513328 +R156N,NP_000537:p.Arg156Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.29318,1.7406615018844604,1.43163,1.4702769641656537,0.862405,0.8817284820828268,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.2511,1.8853,-22.2096,-3.99777403960999,0.0245698465096838,Benign,0.8244,pathogenic,-3.482,available,https://doi.org/10.1101/2022.10.22.513328 +R156P,NP_000537:p.Arg156Pro,"hg19,17:g.7578463C>G, hg19,17:g.7675145C>G, hg38,17:g.7675145C>G",,,0.609,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634768,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,5.02486,3.22200608253479,5.04932,4.765348612826188,5.03709,4.895104306413094,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.3783,1.8853,-22.2096,-4.67495615038927,0.0728951347826166,Benign,0.9793,pathogenic,-3.644,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R156Q,NP_000537:p.Arg156Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.11411,1.447574257850647,0.8449,1.3679250588718237,0.36539499999999997,0.6269075294359119,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.211,1.8853,-22.2096,-3.27661061520608,0.0007299895989928,Benign,0.1429,benign,-3.218,available,https://doi.org/10.1101/2022.10.22.513328 +R156S,NP_000537:p.Arg156Ser,"hg19,17:g.7578464G>T, hg38,17:g.7675146G>T",,,0.523,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1742298,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.20075,1.5661402940750122,1.47721,1.7521963193108985,1.3389799999999998,1.4764731596554492,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.169,1.8853,-8.9217,-2.74605685958695,0.0038579046441381,Benign,0.6905,pathogenic,-3.33,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R156T,NP_000537:p.Arg156Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.46922,1.1651301383972168,0.62653,1.2547932201776986,0.547875,0.8620066100888493,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.2411,1.8853,-22.2096,-1.82458859592878,0.001184489018864,Benign,0.4236,ambiguous,-3.285,available,https://doi.org/10.1101/2022.10.22.513328 +R156V,NP_000537:p.Arg156Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.47995,1.274345874786377,-0.34694,0.6638521310752762,-0.413445,0.0919510655376381,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.07,E,-0.1432,1.8853,-0.737,-0.821931873321886,1.965324480471501e-09,Benign,0.3593,ambiguous,-2.918,available,https://doi.org/10.1101/2022.10.22.513328 +R156W,NP_000537:p.Arg156Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.26015,0.5750312805175781,0.24354,0.0166911041108341,-0.008304999999999993,-0.12172944794458294,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.07,E,-0.254,1.8853,-22.2096,-3.07237716340324,0.0137224585611587,Benign,0.2709,benign,-3.562,available,https://doi.org/10.1101/2022.10.22.513328 +R156Y,NP_000537:p.Arg156Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.24795,0.8610351085662842,-0.12007,0.3259451140771285,-0.6840099999999999,-0.46100244296143567,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,Uncertain,,Uncertain,,,Uncertain,27.0,,False,27.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.07,E,-0.2577,1.8853,-22.2096,-2.68529061448795,0.0001505148817471,Benign,0.4762,ambiguous,-3.375,available,https://doi.org/10.1101/2022.10.22.513328 +V157A,NP_000537:p.Val157Ala,"hg19,17:g.7578460A>G, hg38,17:g.7675142A>G",,,0.848,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428887,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.7101,2.623054981231689,3.12789,2.76836933921183,3.418995,3.2392346696059153,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.2201,1.4207,-22.2096,-6.03177136945862,0.8506491824178575,Pathogenic,0.9464,pathogenic,-4.026,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157C,NP_000537:p.Val157Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.65166,1.71894371509552,2.60816,2.4770106894168933,2.6299099999999997,2.5643353447084465,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.248,1.4207,-22.2096,-6.03177136945862,0.8340472145442,Pathogenic,0.9744,pathogenic,-4.118,available,https://doi.org/10.1101/2022.10.22.513328 +V157D,NP_000537:p.Val157Asp,"hg19,17:g.7578460A>T, hg19,17:g.7675142A>T, hg38,17:g.7675142A>T",,,0.863,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",482231,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.27291,3.737501621246338,3.97211,4.146984570505198,3.62251,3.709947285252599,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.3867,1.4207,-22.2096,-6.54106190246927,0.8343084508991363,Pathogenic,0.9992,pathogenic,-4.568,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157E,NP_000537:p.Val157Glu,"hg38,17:g.7675141_7675142delinsTT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.89001,3.667419672012329,3.81088,4.016492076183867,4.350445000000001,4.453251038091933,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.41,E,-0.344,1.4207,-22.2096,-6.54106190246927,0.8255579501020398,Pathogenic,0.9966,pathogenic,-4.515,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157F,NP_000537:p.Val157Phe,"hg19,17:g.7578461C>A, hg19,17:g.7675143C>A, hg38,17:g.7675143C>A, hg38,17:g.7675143_7675144delinsAA, hg38,17:g.7675143_7675144delinsAT",,,0.708,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12353,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.11044,2.145390272140503,3.47007,2.436083942639077,5.290255,4.773261971319538,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.2214,1.4207,-7.3368,-3.18514303664848,0.8019161184297998,Pathogenic,0.9349,pathogenic,-4.016,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157G,NP_000537:p.Val157Gly,"hg19,17:g.7578459_7578460delinsAC, hg19,17:g.7578460A>C, hg19,17:g.7675142A>C, hg38,17:g.7675141_7675142delinsAC, hg38,17:g.7675142A>C",,,0.872,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","3148383, 915695","Likely pathogenic, Pathogenic/Likely pathogenic","1, 2",,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,5.39919,3.464676856994629,5.43367,4.841118468184022,5.41643,5.120154234092011,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.3459,1.4207,-22.2096,-6.54106190246927,0.7995863355789101,Pathogenic,0.9524,pathogenic,-4.427,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157H,NP_000537:p.Val157His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.6772,3.6022396087646484,4.59694,3.2415071764421985,6.13707,5.4593535882210995,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.3897,1.4207,-22.2096,-5.9252980949022,0.8362842528324033,Pathogenic,0.9988,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328 +V157I,NP_000537:p.Val157Ile,"hg19,17:g.7578461C>T, hg38,17:g.7675143C>T",,3.97921259341e-05,0.425,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",185404,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.88767,-0.111114501953125,0.07483,-0.0010532058792545,-0.40642,-0.44436160293962723,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.0461,1.4207,-0.737,-0.27683081420522,4.169943083037448e-08,Benign,0.1052,benign,-2.904,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157K,NP_000537:p.Val157Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.28988,3.619154930114746,6.34388,4.894008280108477,5.81688,5.091944140054238,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.383,1.4207,-22.2096,-6.54106190246927,0.8337409124340375,Pathogenic,0.9971,pathogenic,-4.538,available,https://doi.org/10.1101/2022.10.22.513328 +V157L,NP_000537:p.Val157Leu,"hg19,17:g.7578461C>G, hg19,17:g.7675143C>G, hg38,17:g.7675143C>G",,,0.546,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1515529,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.64629,0.9805862903594972,1.77109,0.7091572306767635,1.20869,0.6777236153383818,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.1216,1.4207,-2.7926,-1.65744017387142,2.1357464196808862e-06,Benign,0.6073,pathogenic,-3.005,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V157M,NP_000537:p.Val157Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.39157,1.980439186096192,1.31531,1.8396130972870235,1.35344,1.6155915486435117,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.2298,1.4207,-22.2096,-3.92629450142789,0.7838199736330359,Pathogenic,0.856,pathogenic,-4.016,available,https://doi.org/10.1101/2022.10.22.513328 +V157N,NP_000537:p.Val157Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.9513,3.724606513977051,2.97279,2.721829653438668,2.962045,2.836564826719334,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.3746,1.4207,-22.2096,-6.54106190246927,0.7447682330697962,Pathogenic,0.997,pathogenic,-4.464,available,https://doi.org/10.1101/2022.10.22.513328 +V157P,NP_000537:p.Val157Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.3223,3.583211660385132,5.39626,5.529638020769092,5.35928,5.425969010384546,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.4244,1.4207,-22.2096,-6.54106190246927,0.823675674972593,Pathogenic,0.9948,pathogenic,-4.258,available,https://doi.org/10.1101/2022.10.22.513328 +V157Q,NP_000537:p.Val157Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.11582,3.741729021072388,3.07143,3.0236197082772347,3.5936250000000003,3.5697198541386177,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.41,E,-0.3546,1.4207,-22.2096,-6.54106190246927,0.8315062836184418,Pathogenic,0.9957,pathogenic,-4.419,available,https://doi.org/10.1101/2022.10.22.513328 +V157R,NP_000537:p.Val157Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.89985,3.511906147003174,6.36905,4.15758406813172,6.134449999999999,5.02871703406586,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.404,1.4207,-22.2096,-6.54106190246927,0.8271034459001179,Pathogenic,0.9941,pathogenic,-4.37,available,https://doi.org/10.1101/2022.10.22.513328 +V157S,NP_000537:p.Val157Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.77448,3.506444931030273,3.8881,3.513097689997252,4.33129,4.1437888449986255,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.3238,1.4207,-22.2096,-6.03177136945862,0.8303028750561633,Pathogenic,0.9901,pathogenic,-4.244,available,https://doi.org/10.1101/2022.10.22.513328 +V157T,NP_000537:p.Val157Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.5605,2.5210771560668945,1.90578,2.144367002135595,2.23314,2.3524335010677975,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.1662,1.4207,-7.9218,-4.43536378738608,0.7963706965341553,Pathogenic,0.9748,pathogenic,-4.09,available,https://doi.org/10.1101/2022.10.22.513328 +V157W,NP_000537:p.Val157Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.98752,2.728421211242676,4.6949,3.861905144783724,9.34121,8.924712572391861,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.3378,1.4207,-22.2096,-5.9252980949022,0.8090995667678536,Pathogenic,0.9983,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328 +V157Y,NP_000537:p.Val157Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.83344,2.629435539245605,4.1,3.3818803296020774,5.9667200000000005,5.607660164801039,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.071,,,,,,,,,0.4,,False,0.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.3407,1.4207,-22.2096,-5.9252980949022,0.8193908616849128,Pathogenic,0.9927,pathogenic,-4.37,available,https://doi.org/10.1101/2022.10.22.513328 +R158A,NP_000537:p.Arg158Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.16378,1.483901858329773,1.86837,1.3798596760972652,2.516075,2.2718198380486325,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.4001,0.1043,-22.2096,-7.1028394778161,0.8050741506879635,Pathogenic,0.9977,pathogenic,-4.342,available,https://doi.org/10.1101/2022.10.22.513328 +R158C,NP_000537:p.Arg158Cys,"hg19,17:g.7578458G>A, hg19,17:g.7578458_7578459delinsAA, hg19,17:g.7675140G>A, hg38,17:g.7675138_7675140delinsACA, hg38,17:g.7675140G>A, hg38,17:g.7675140_7675141delinsAA",,7.9593753482e-06,0.835,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127812,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.46246,1.3888790607452393,1.92211,1.514710375887271,2.692285,2.4885851879436354,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.409,0.1043,-22.2096,-6.77998842762731,0.0402279186236466,Benign,0.9622,pathogenic,-3.874,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158D,NP_000537:p.Arg158Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.2204,3.0835161209106445,2.71973,2.74079749383808,3.970065,3.98059874691904,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.4912,0.1043,-22.2096,-7.8974356797228,0.7960539498923963,Pathogenic,0.9994,pathogenic,-4.604,available,https://doi.org/10.1101/2022.10.22.513328 +R158E,NP_000537:p.Arg158Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.51889,2.5151140689849854,1.59456,2.013878380843871,3.056725,3.2663841904219355,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.4364,0.1043,-22.2096,-7.8974356797228,0.8383647753557675,Pathogenic,0.9952,pathogenic,-4.456,available,https://doi.org/10.1101/2022.10.22.513328 +R158F,NP_000537:p.Arg158Phe,"hg19,17:g.7578456_7578458delinsAAA, hg19,17:g.7578457_7578458delinsAA, hg38,17:g.7675139_7675140delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.82024,1.0685300827026367,0.47041,0.5357180951415049,5.645325,5.677979047570752,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.38,E,-0.4323,0.1043,-22.2096,-6.94790315070581,0.6834057698841777,Pathogenic,0.9992,pathogenic,-4.331,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158G,NP_000537:p.Arg158Gly,"hg19,17:g.7578458G>C, hg19,17:g.7675140G>C, hg38,17:g.7675140G>C",,,0.862,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",856171,Pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,4.22923,2.321451187133789,3.45816,2.9531911050141773,3.8436950000000003,3.5912105525070888,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.4355,0.1043,-22.2096,-7.8974356797228,0.7385355247444985,Pathogenic,0.9963,pathogenic,-4.418,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158H,NP_000537:p.Arg158His,"hg19,17:g.7578457C>T, hg19,17:g.7675139C>T, hg38,17:g.7675139C>T",,3.9798143815e-06,0.844,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141963,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.49214,1.8500467538833616,1.63912,1.0388592153091802,4.56563,4.26549960765459,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.2902,0.1043,-6.5999,-4.0144422087353,0.001325604384502,Benign,0.9236,pathogenic,-3.528,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158I,NP_000537:p.Arg158Ile,"hg19,17:g.7578456_7578458delinsAAT, hg38,17:g.7675138_7675140delinsAAT",,,,"ClinVar,saturation_mutlist",958850,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.15202,0.841417670249939,0.17109,0.0081870579790865,1.661555,1.580103528989543,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.4295,0.1043,-22.2096,-7.28243726462348,0.796711831584717,Pathogenic,0.9971,pathogenic,-4.418,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158K,NP_000537:p.Arg158Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.08684,0.586187481880188,1.35034,1.6419007005787591,1.71859,1.8643703502893796,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.38,E,-0.2226,0.1043,-8.9217,-2.91084196007257,0.0429422234378775,Benign,0.9285,pathogenic,-3.656,available,https://doi.org/10.1101/2022.10.22.513328 +R158L,NP_000537:p.Arg158Leu,"hg19,17:g.7578456_7578457delinsAA, hg19,17:g.7578457C>A, hg19,17:g.7675139C>A, hg38,17:g.7675138_7675139delinsAA, hg38,17:g.7675139C>A",,3.9798143815e-06,0.891,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","568285, 528248","Pathogenic/Likely pathogenic, Pathogenic","2, 3",,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.54833,1.2527549266815186,0.54422,0.0721768911790082,1.046275,0.8102534455895041,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.4026,0.1043,-22.2096,-7.28243726462348,0.6435048833731373,Uncertain,0.9902,pathogenic,-4.204,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158M,NP_000537:p.Arg158Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.72254,1.108084201812744,1.08129,0.6951129840750888,1.401915,1.2088264920375444,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.3684,0.1043,-22.2096,-7.28243726462348,0.7715392029099782,Pathogenic,0.9989,pathogenic,-4.373,available,https://doi.org/10.1101/2022.10.22.513328 +R158N,NP_000537:p.Arg158Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.30673,2.291426181793213,2.06599,1.4456464900315753,3.18636,2.8761882450157876,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.415,0.1043,-22.2096,-7.8974356797228,0.8354581091440914,Pathogenic,0.9989,pathogenic,-4.331,available,https://doi.org/10.1101/2022.10.22.513328 +R158P,NP_000537:p.Arg158Pro,"hg19,17:g.7578456_7578457delinsAG, hg19,17:g.7578457C>G, hg19,17:g.7578457_7578459delinsGGA, hg19,17:g.7675139C>G, hg38,17:g.7675139C>G",,,0.916,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",246118,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,4.38879,2.718482494354248,2.47143,3.7716404802990056,3.43011,4.080215240149503,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.5422,0.1043,-22.2096,-7.8974356797228,0.7643157860762336,Pathogenic,0.9986,pathogenic,-4.48,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158Q,NP_000537:p.Arg158Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.56933,1.6965506076812744,0.87245,1.3735176303975982,2.22089,2.471423815198799,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.3748,0.1043,-22.2096,-7.8974356797228,0.7280116113949682,Pathogenic,0.9552,pathogenic,-4.004,available,https://doi.org/10.1101/2022.10.22.513328 +R158S,NP_000537:p.Arg158Ser,"hg19,17:g.7578458G>T, hg19,17:g.7675140G>T, hg38,17:g.7675140G>T",,,0.864,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1067910,Pathogenic,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,3.30992,1.5702080726623535,2.42041,1.8536653554906903,2.865165,2.5817926777453453,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.4007,0.1043,-22.2096,-7.1028394778161,0.3648532772081086,Uncertain,0.9981,pathogenic,-4.09,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R158T,NP_000537:p.Arg158Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.90824,1.2423760890960691,1.33095,0.9693201970734237,2.6195950000000003,2.438780098536712,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.405,0.1043,-22.2096,-7.1028394778161,0.8311202221216565,Pathogenic,0.9979,pathogenic,-4.126,available,https://doi.org/10.1101/2022.10.22.513328 +R158V,NP_000537:p.Arg158Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.01244,0.8653275966644287,0.17619,0.0623785898172274,1.094315,1.0374092949086136,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.38,E,-0.4166,0.1043,-22.2096,-6.70684669011845,0.4215891016473184,Uncertain,0.9953,pathogenic,-4.059,available,https://doi.org/10.1101/2022.10.22.513328 +R158W,NP_000537:p.Arg158Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,11.14079,1.4447519779205322,0.41769,0.5343562339364524,5.779240000000001,5.837573116968227,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.38,E,-0.4179,0.1043,-22.2096,-6.94790315070581,0.7744905473454666,Pathogenic,0.9826,pathogenic,-4.356,available,https://doi.org/10.1101/2022.10.22.513328 +R158Y,NP_000537:p.Arg158Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.66563,1.273975133895874,0.50782,0.9169585698082756,4.086725,4.291294284904138,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.092,,,,,,,,,18.9,,False,18.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.38,E,-0.4216,0.1043,-22.2096,-6.94790315070581,0.7780450112465993,Pathogenic,0.9961,pathogenic,-4.408,available,https://doi.org/10.1101/2022.10.22.513328 +A159C,NP_000537:p.Ala159Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.11834,-0.8608015179634094,0.30816,1.1347852852261635,0.7132499999999999,1.1265626426130817,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3172,0.2526,-22.2096,-3.75335838591384,0.3050808316386852,Benign,0.7688,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328 +A159D,NP_000537:p.Ala159Asp,"hg19,17:g.7578454G>T, hg19,17:g.7675136G>T, hg38,17:g.7675136G>T",,,0.836,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1026335,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,4.55058,2.583397626876831,2.38061,3.100301843380798,3.465595,3.825440921690399,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3989,0.2526,-22.2096,-7.56118054309627,0.7783769042694721,Pathogenic,0.9985,pathogenic,-4.448,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159E,NP_000537:p.Ala159Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.76315,1.913447618484497,2.75442,3.8210738242381614,4.2587850000000005,4.792111912119081,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3846,0.2526,-22.2096,-7.56118054309627,0.7696593704216773,Pathogenic,0.9976,pathogenic,-4.44,available,https://doi.org/10.1101/2022.10.22.513328 +A159F,NP_000537:p.Ala159Phe,"hg19,17:g.7578454_7578455delinsAA, hg38,17:g.7675136_7675137delinsAA",,,,"ClinVar,saturation_mutlist",182961,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.02688,-1.5893616676330566,2.00272,3.3084118523498343,7.0148,7.6676459261749175,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3673,0.2526,-22.2096,-7.56118054309627,0.756637955227241,Pathogenic,0.979,pathogenic,-4.203,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159G,NP_000537:p.Ala159Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.19013,0.97222501039505,3.17517,2.277650341290297,2.6826499999999998,2.2338901706451484,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.48,E,-0.3107,0.2526,-22.2096,-5.92587399176263,0.0737808386571025,Benign,0.5551,ambiguous,-3.672,available,https://doi.org/10.1101/2022.10.22.513328 +A159H,NP_000537:p.Ala159His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.2723,0.992470920085907,3.26973,3.5320470756537223,8.271015,8.402173537826862,Destabilizing,Destabilizing,Neutral,Destabilizing,Destabilizing,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3036,0.2526,-8.9217,-7.56118054309627,0.4037162014164137,Uncertain,0.9973,pathogenic,-4.184,available,https://doi.org/10.1101/2022.10.22.513328 +A159I,NP_000537:p.Ala159Ile,"hg19,17:g.7578454_7578455delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.05679,-2.047447919845581,0.52211,1.39528059729425,0.23265999999999998,0.669245298647125,Neutral,Neutral,Stabilizing,Neutral,Neutral,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3568,0.2526,-22.2096,-4.90453163501885,0.0157143104023936,Benign,0.9256,pathogenic,-3.786,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159K,NP_000537:p.Ala159Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.60795,0.8968528509140015,4.89422,6.458062537921651,6.251085,7.0330062689608255,Destabilizing,Destabilizing,Neutral,Destabilizing,Destabilizing,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3892,0.2526,-22.2096,-7.56118054309627,0.7825933181932001,Pathogenic,0.9994,pathogenic,-4.595,available,https://doi.org/10.1101/2022.10.22.513328 +A159L,NP_000537:p.Ala159Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.86582,-1.8220393657684328,1.4085,1.5678862908914704,2.1371599999999997,2.216853145445735,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3616,0.2526,-22.2096,-5.96592803911561,0.0502942583274685,Benign,0.8367,pathogenic,-3.998,available,https://doi.org/10.1101/2022.10.22.513328 +A159M,NP_000537:p.Ala159Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.15479,-1.456308364868164,0.29286,2.035444308936461,1.7238250000000002,2.5951171544682303,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3203,0.2526,-22.2096,-5.96592803911561,0.7734323157306574,Pathogenic,0.8932,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328 +A159N,NP_000537:p.Ala159Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.39821,1.4662091732025146,0.93435,1.946311892789996,2.16628,2.672260946394998,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3015,0.2526,-8.9217,-7.56118054309627,0.7279914176699548,Pathogenic,0.9914,pathogenic,-4.402,available,https://doi.org/10.1101/2022.10.22.513328 +A159P,NP_000537:p.Ala159Pro,"hg19,17:g.7578455C>G, hg19,17:g.7675137C>G, hg38,17:g.7675137C>G",,,0.815,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182929,Conflicting classifications of pathogenicity,1,Oncogenic,2,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.84746,1.3591861724853516,4.55442,5.821212542674343,3.70094,4.334336271337172,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.4387,0.2526,-22.2096,-7.56118054309627,0.7604955788970156,Pathogenic,0.9973,pathogenic,-4.248,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159Q,NP_000537:p.Ala159Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.60559,1.1714882850646973,1.58061,2.4962453208289146,4.5931,5.050917660414457,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3668,0.2526,-22.2096,-7.56118054309627,0.7759311807133028,Pathogenic,0.9938,pathogenic,-4.432,available,https://doi.org/10.1101/2022.10.22.513328 +A159R,NP_000537:p.Ala159Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.09389,0.740920901298523,6.7068,5.579653575363392,9.400345,8.836771787681696,Destabilizing,Destabilizing,Neutral,Destabilizing,Destabilizing,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3999,0.2526,-22.2096,-7.56118054309627,0.7621906723278383,Pathogenic,0.9967,pathogenic,-4.475,available,https://doi.org/10.1101/2022.10.22.513328 +A159S,NP_000537:p.Ala159Ser,"hg38,17:g.7675137C>A",,,0.727,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.56025,0.9772812724113464,0.98129,1.541663367689714,1.27077,1.550956683844857,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.48,E,-0.2819,0.2526,-22.2096,-3.62081775220914,0.0835691784716668,Benign,0.4783,ambiguous,-3.582,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159T,NP_000537:p.Ala159Thr,"hg19,17:g.7578455C>T, hg38,17:g.7675137C>T",,0.0,0.715,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1909172,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.08183,0.6497130393981934,0.28605,1.413800474155618,0.68394,1.247815237077809,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.2006,0.2526,-5.1145,-0.819721990404372,3.507067245615645e-09,Benign,0.4315,ambiguous,-3.202,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159V,NP_000537:p.Ala159Val,"hg19,17:g.7578453_7578454delinsAA, hg19,17:g.7578454G>A, hg19,17:g.7675136G>A, hg38,17:g.7675135_7675136delinsAA, hg38,17:g.7675136G>A",,,0.774,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458545,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,-0.35939,-1.493349552154541,0.35102,0.5267428461007312,-0.004184999999999994,0.0836764230503656,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.2171,0.2526,-8.9217,-4.45460517452887,0.0025011567623869,Benign,0.6808,pathogenic,-3.412,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A159W,NP_000537:p.Ala159Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,14.68166,-0.0902498364448547,4.18299,5.983053291545883,9.432325,10.332356645772942,Destabilizing,Destabilizing,Neutral,Destabilizing,Destabilizing,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3782,0.2526,-22.2096,-7.56118054309627,0.6802380398553227,Pathogenic,0.999,pathogenic,-4.546,available,https://doi.org/10.1101/2022.10.22.513328 +A159Y,NP_000537:p.Ala159Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,18.09228,-0.2218891382217407,2.35204,4.958680282004703,10.222159999999999,11.525480141002351,Uncertain,Destabilizing,Neutral,Destabilizing,Destabilizing,False,0.108,,,,,,,,,0.1,,False,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.48,E,-0.3865,0.2526,-22.2096,-7.56118054309627,0.7954557153601984,Pathogenic,0.9967,pathogenic,-4.441,available,https://doi.org/10.1101/2022.10.22.513328 +M160A,NP_000537:p.Met160Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.52721,1.6115304231643677,1.56531,1.927504202459274,2.04626,2.227357101229637,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.319,0.8986,-22.2419,-4.77197012238704,0.2406404998338247,Benign,0.9231,pathogenic,-3.858,available,https://doi.org/10.1101/2022.10.22.513328 +M160C,NP_000537:p.Met160Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.15883,0.3105427026748657,1.32721,1.957384358857032,1.74302,2.058107179428516,Uncertain,Uncertain,Neutral,Neutral,Uncertain,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.3245,0.8986,-22.2419,-4.94159724921602,0.830441929306543,Pathogenic,0.9567,pathogenic,-3.993,available,https://doi.org/10.1101/2022.10.22.513328 +M160D,NP_000537:p.Met160Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.78805,1.683435559272766,2.62415,3.090469456793272,3.2061,3.439259728396636,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.4305,0.8986,-22.2419,-6.3898967312866,0.8073356203134741,Pathogenic,0.9993,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328 +M160E,NP_000537:p.Met160Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.58959,0.6670126914978027,1.32177,2.365883856308078,1.9556799999999999,2.477736928154039,Uncertain,Uncertain,Neutral,Neutral,Uncertain,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.4207,0.8986,-22.2419,-6.3898967312866,0.495560462399917,Uncertain,0.9884,pathogenic,-4.227,available,https://doi.org/10.1101/2022.10.22.513328 +M160F,NP_000537:p.Met160Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.21906,0.499600887298584,0.76429,0.4208206714786827,2.491675,2.319940335739341,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.3241,0.8986,-22.2419,-6.56200410044584,0.7661135055131366,Pathogenic,0.9205,pathogenic,-4.014,available,https://doi.org/10.1101/2022.10.22.513328 +M160G,NP_000537:p.Met160Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.78706,2.568389654159546,3.1915,3.264977644621384,3.48928,3.526018822310692,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.327,0.8986,-7.9541,-4.11470891517805,0.2375769303336883,Benign,0.9861,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328 +M160H,NP_000537:p.Met160His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.25429,1.7874730825424194,2.86837,1.370077735600641,2.06133,1.3121838678003206,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.3773,0.8986,-22.2419,-6.56200410044584,0.7557188852588048,Pathogenic,0.9933,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +M160I,NP_000537:p.Met160Ile,"hg19,17:g.7578450C>A, hg19,17:g.7578450C>G, hg19,17:g.7578450C>T, hg19,17:g.7675132C>A, hg38,17:g.7675132C>A, hg38,17:g.7675132C>G, hg38,17:g.7675132C>T",,1.19374477737e-05,"0.656, 0.657","cBioPortal,COSMIC,ClinVar,saturation_mutlist",230758,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22395,0.3709075450897217,-0.08299,0.0061501204359221,0.07048000000000001,0.11505006021796106,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.0,E,-0.1634,0.8986,-7.9541,-1.85806821306715,0.0241597896788447,Benign,0.9318,pathogenic,-3.424,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160K,NP_000537:p.Met160Lys,"hg19,17:g.7578451A>T, hg38,17:g.7675133A>T",,,0.860,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.31869,2.706648826599121,2.10544,2.199473613590502,1.712065,1.7590818067952512,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.3816,0.8986,-22.2419,-6.49813689004754,0.4216083122230772,Uncertain,0.9752,pathogenic,-4.028,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160L,NP_000537:p.Met160Leu,"hg19,17:g.7578452T>G, hg38,17:g.7675134T>G",,,0.569,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.05114,0.4686168432235718,0.43435,-0.1096365546608324,0.191605,-0.0803882773304162,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.0,E,-0.1253,0.8986,-6.9542,-0.71506230071988,0.0089578048694624,Benign,0.4727,ambiguous,-3.342,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160N,NP_000537:p.Met160Asn,"hg19,17:g.7578450_7578451delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.67903,2.196303606033325,2.36905,1.931469318907792,2.5240400000000003,2.305249659453896,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.3721,0.8986,-22.2419,-6.3898967312866,0.8246781190807602,Pathogenic,0.9874,pathogenic,-4.28,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160P,NP_000537:p.Met160Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.11793,3.494584560394287,2.96939,4.98250910761207,3.54366,4.550219553806035,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.49,0.8986,-22.2419,-6.9321485527439,0.7607710446302134,Pathogenic,0.9996,pathogenic,-4.461,available,https://doi.org/10.1101/2022.10.22.513328 +M160Q,NP_000537:p.Met160Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.01393,1.3548096418380735,1.47959,1.60837201540492,1.74676,1.8111510077024602,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.3642,0.8986,-22.2419,-5.93922847820589,0.3415850343102615,Uncertain,0.9302,pathogenic,-3.95,available,https://doi.org/10.1101/2022.10.22.513328 +M160R,NP_000537:p.Met160Arg,"hg19,17:g.7578451A>C, hg38,17:g.7675133A>C",,,0.865,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.99709,2.510533332824707,1.7568,1.3969428956579657,1.876945,1.6970164478289829,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.4089,0.8986,-22.2419,-6.69861340466964,0.7302922830871812,Pathogenic,0.978,pathogenic,-3.957,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160S,NP_000537:p.Met160Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.86248,1.6222922801971436,2.17721,2.5106161594299445,2.519845,2.6865480797149726,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.3504,0.8986,-22.2419,-4.77991809731783,0.4813826400138841,Uncertain,0.9369,pathogenic,-3.926,available,https://doi.org/10.1101/2022.10.22.513328 +M160T,NP_000537:p.Met160Thr,"hg19,17:g.7578451A>G, hg38,17:g.7675133A>G",,,0.669,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2915501,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.21008,1.1585497856140137,0.95374,1.5692039932336117,1.5819100000000001,1.8896419966168059,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.1894,0.8986,-2.4948,-2.5259026466363,6.161701149059683e-06,Benign,0.5246,ambiguous,-3.189,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160V,NP_000537:p.Met160Val,"hg19,17:g.7578452T>C, hg38,17:g.7675134T>C",,3.979370941e-06,0.689,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",444396,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.88868,0.4332278966903686,0.00476,0.3294097725183786,0.44672,0.6090448862591893,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.1904,0.8986,-6.9542,-1.85792401129712,0.0001529524193019,Benign,0.2649,benign,-3.319,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M160W,NP_000537:p.Met160Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.8082,0.8052413463592529,-0.71905,0.631992201356904,4.544575,5.220096100678452,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.319,0.8986,-8.9541,-6.56200410044584,0.7911684008175226,Pathogenic,0.9944,pathogenic,-4.312,available,https://doi.org/10.1101/2022.10.22.513328 +M160Y,NP_000537:p.Met160Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.57962,1.029565930366516,1.31088,0.882837505404851,3.94525,3.7312287527024255,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.115,,,,,,,,,18.4,,False,18.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.0,E,-0.3664,0.8986,-22.2419,-6.13525996681711,0.6736527943234092,Uncertain,0.9933,pathogenic,-4.153,available,https://doi.org/10.1101/2022.10.22.513328 +A161C,NP_000537:p.Ala161Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.0631,-0.3844349384307861,0.29762,0.9677540084989034,0.18036,0.5154270042494516,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.2503,0.9816,-22.239,-4.49556005485196,0.7267499076720001,Pathogenic,0.9503,pathogenic,-4.182,available,https://doi.org/10.1101/2022.10.22.513328 +A161D,NP_000537:p.Ala161Asp,"hg19,17:g.7578448G>T, hg19,17:g.7675130G>T, hg38,17:g.7675130G>T",,,0.908,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",422295,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.68196,2.117010593414306,1.64796,2.545755529971434,2.16496,2.613857764985717,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.332,0.9816,-22.239,-6.93735650167601,0.8705275416768172,Pathogenic,0.9987,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161E,NP_000537:p.Ala161Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.61219,2.200678825378418,2.86361,2.5692452003159314,2.7379,2.5907176001579657,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.3176,0.9816,-22.239,-6.93735650167601,0.8707342242878764,Pathogenic,0.9983,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +A161F,NP_000537:p.Ala161Phe,"hg38,17:g.7675130_7675131delinsAA",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.94132,0.6731430888175964,3.46973,1.334677915087586,4.705525,3.637998957543793,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.3004,0.9816,-22.239,-6.93735650167601,0.86057056466432,Pathogenic,0.995,pathogenic,-4.393,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161G,NP_000537:p.Ala161Gly,"hg19,17:g.7578447_7578448delinsTC, hg19,17:g.7578448G>C, hg38,17:g.7675129_7675130delinsTC, hg38,17:g.7675130G>C",,,0.809,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3460338,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.18044,1.469440221786499,2.52721,2.0318793816335847,2.353825,2.106159690816792,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.91,E,-0.2438,0.9816,-22.239,-6.51573930634988,0.7869818846508665,Pathogenic,0.7679,pathogenic,-4.063,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161H,NP_000537:p.Ala161His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.96577,1.6901627779006958,3.32993,1.762793264920105,4.14785,3.3642816324600524,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.3045,0.9816,-22.239,-6.93735650167601,0.8667690769504365,Pathogenic,0.999,pathogenic,-4.393,available,https://doi.org/10.1101/2022.10.22.513328 +A161I,NP_000537:p.Ala161Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.16826,-0.2350412607192993,-0.59728,0.7484838566900173,-0.38277,0.29011192834500865,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.2899,0.9816,-22.239,-5.38283723695913,0.7672439487367823,Pathogenic,0.984,pathogenic,-4.076,available,https://doi.org/10.1101/2022.10.22.513328 +A161K,NP_000537:p.Ala161Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.23322,2.166210651397705,4.93673,3.2300041650385767,5.084975,4.231612082519288,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.3223,0.9816,-22.239,-6.68621541521553,0.8199796158353415,Pathogenic,0.9996,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328 +A161L,NP_000537:p.Ala161Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.76623,-0.3019279241561889,-0.7881,0.8518566346258033,-0.777165,0.042813317312901666,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.2946,0.9816,-22.239,-5.03374028199389,0.2302807973793351,Benign,0.8551,pathogenic,-3.778,available,https://doi.org/10.1101/2022.10.22.513328 +A161M,NP_000537:p.Ala161Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.63134,0.2642346620559692,0.69728,1.2809315240565875,1.16431,1.4561357620282938,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.2534,0.9816,-22.239,-4.89819363771835,0.5579765632502982,Uncertain,0.9748,pathogenic,-3.895,available,https://doi.org/10.1101/2022.10.22.513328 +A161N,NP_000537:p.Ala161Asn,,,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.2089,1.6700624227523804,1.59422,1.4775803994487495,1.40156,1.3432401997243748,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.3024,0.9816,-22.239,-6.93735650167601,0.869962268212941,Pathogenic,0.996,pathogenic,-4.35,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161P,NP_000537:p.Ala161Pro,"hg19,17:g.7578449C>G, hg38,17:g.7675131C>G",,,0.641,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3258033,,,Uncertain significance,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.671,1.5781972408294678,1.6602,3.844503629521917,-0.005400000000000071,1.0867518147609583,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.2622,0.9816,-0.7864,-1.97218037891763,0.0062827088077968,Benign,0.6616,pathogenic,-3.236,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161Q,NP_000537:p.Ala161Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.70724,1.9146366119384768,1.34388,1.8048043244639245,2.02556,2.2560221622319623,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.2998,0.9816,-22.239,-6.93735650167601,0.8693768162184736,Pathogenic,0.9959,pathogenic,-4.363,available,https://doi.org/10.1101/2022.10.22.513328 +A161R,NP_000537:p.Ala161Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.99138,2.3431649208068848,6.94184,2.182607895215453,7.46661,5.086993947607727,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.333,0.9816,-22.239,-6.68621541521553,0.8678597531210588,Pathogenic,0.9971,pathogenic,-4.434,available,https://doi.org/10.1101/2022.10.22.513328 +A161S,NP_000537:p.Ala161Ser,"hg19,17:g.7578449C>A, hg19,17:g.7675131C>A, hg38,17:g.7675131C>A",,,0.752,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.69958,1.0336015224456787,1.11531,1.3859916540111763,1.407445,1.5427858270055883,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.91,E,-0.215,0.9816,-22.239,-2.6744212924387,0.6274457528900252,Uncertain,0.782,pathogenic,-3.941,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161T,NP_000537:p.Ala161Thr,"hg19,17:g.7578449C>T, hg19,17:g.7675131C>T, hg38,17:g.7675129_7675131delinsAGT, hg38,17:g.7675131C>T",,,0.790,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",161518,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.44664,0.618278980255127,0.86395,1.0460962003512826,0.655295,0.7463681001756413,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.2209,0.9816,-22.239,-4.49556005485196,0.8467989928906021,Pathogenic,0.9563,pathogenic,-3.885,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161V,NP_000537:p.Ala161Val,"hg19,17:g.7578448G>A, hg19,17:g.7675130G>A, hg38,17:g.7675130G>A",,,0.803,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2019530,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.8961,-0.6764141321182251,-0.9415,0.1586504579536407,-0.9188000000000001,-0.3687247710231797,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.218,0.9816,-22.239,-4.45493542331487,0.4081706732339358,Uncertain,0.8937,pathogenic,-3.604,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A161W,NP_000537:p.Ala161Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.64198,1.2694686651229858,6.58605,2.4388340497705965,10.114015,8.040407024885297,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.3113,0.9816,-22.239,-6.93735650167601,0.8703795534490344,Pathogenic,0.9997,pathogenic,-4.642,available,https://doi.org/10.1101/2022.10.22.513328 +A161Y,NP_000537:p.Ala161Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.64094,1.1446192264556885,3.88776,1.9120814406324933,4.76435,3.7765107203162467,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.135,,,,,,,,,5.6,,False,5.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.91,E,-0.3195,0.9816,-22.239,-6.93735650167601,0.8704707130705853,Pathogenic,0.9988,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328 +I162A,NP_000537:p.Ile162Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.91391,1.7487127780914309,2.53469,2.825685067674528,2.7243,2.8697975338372643,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,E,-0.3426,0.9099,-22.239,-5.52849042925434,0.1171671181663313,Benign,0.95,pathogenic,-3.632,available,https://doi.org/10.1101/2022.10.22.513328 +I162C,NP_000537:p.Ile162Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.22172,0.9617624282836914,2.37857,2.694658296153134,2.3001449999999997,2.458189148076567,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,E,-0.3226,0.9099,-22.239,-5.75718582247629,0.7386498378221988,Pathogenic,0.956,pathogenic,-3.965,available,https://doi.org/10.1101/2022.10.22.513328 +I162D,NP_000537:p.Ile162Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.91112,3.038124322891236,3.97313,4.138565476834362,3.442125,3.524842738417181,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,E,-0.4666,0.9099,-22.239,-6.17096696338336,0.7526404753076472,Pathogenic,0.9994,pathogenic,-4.432,available,https://doi.org/10.1101/2022.10.22.513328 +I162E,NP_000537:p.Ile162Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.0219,2.4088447093963623,3.74422,3.601519718742386,3.38306,3.3117098593711933,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,E,-0.4475,0.9099,-22.239,-6.17096696338336,0.7414635729319449,Pathogenic,0.9975,pathogenic,-4.22,available,https://doi.org/10.1101/2022.10.22.513328 +I162F,NP_000537:p.Ile162Phe,"hg19,17:g.7578446T>A, hg19,17:g.7675128T>A, hg38,17:g.7675128T>A",,,0.676,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",948225,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.3223,1.214298963546753,0.71497,1.6009155711177014,3.518635,3.9616077855588507,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,E,-0.3035,0.9099,-22.239,-5.55546634057379,0.5610062374276473,Uncertain,0.7741,pathogenic,-3.864,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I162G,NP_000537:p.Ile162Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.70975,2.8253893852233887,4.43503,4.906886211260793,4.07239,4.308318105630397,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,E,-0.4332,0.9099,-22.239,-6.17096696338336,0.3185698272600161,Benign,0.9946,pathogenic,-4.054,available,https://doi.org/10.1101/2022.10.22.513328 +I162H,NP_000537:p.Ile162His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.11867,2.270526885986328,2.26463,2.617594777558784,4.19165,4.368132388779392,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,E,-0.4332,0.9099,-22.239,-5.8430531674617,0.7600855709718031,Pathogenic,0.9946,pathogenic,-4.196,available,https://doi.org/10.1101/2022.10.22.513328 +I162K,NP_000537:p.Ile162Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.6388,2.497565031051636,2.92245,4.287468985253026,3.2806249999999997,3.963134492626513,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.3,E,-0.44,0.9099,-22.239,-5.39971652932221,0.3743779722378239,Uncertain,0.9923,pathogenic,-4.074,available,https://doi.org/10.1101/2022.10.22.513328 +I162L,NP_000537:p.Ile162Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.15186,0.6140859127044678,0.71803,0.2202080125605299,0.934945,0.686034006280265,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.3,E,-0.2278,0.9099,-22.239,-2.64933215783147,0.0456621295224262,Benign,0.4472,ambiguous,-3.391,available,https://doi.org/10.1101/2022.10.22.513328 +I162M,NP_000537:p.Ile162Met,"hg19,17:g.7578444G>C, hg38,17:g.7675126G>C",,,0.629,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.13702,0.7564781904220581,0.6898,1.1288831164651896,0.41341,0.6329515582325947,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.3,E,-0.2334,0.9099,-22.239,-2.83824126760049,0.0113200841889445,Benign,0.4763,ambiguous,-3.401,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I162N,NP_000537:p.Ile162Asn,"hg19,17:g.7578445A>T, hg19,17:g.7675127A>T, hg38,17:g.7675127A>T",,,0.800,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1408611,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.16585,2.817378759384156,3.31769,2.6381229932614536,3.24177,2.9019864966307267,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,E,-0.3797,0.9099,-22.239,-6.17096696338336,0.7569032171412376,Pathogenic,0.9882,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I162P,NP_000537:p.Ile162Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.03801,3.3409204483032227,3.34184,6.266484261910194,4.189925,5.652247130955097,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,E,-0.4866,0.9099,-22.239,-6.17096696338336,0.7652740247519739,Pathogenic,0.9976,pathogenic,-4.302,available,https://doi.org/10.1101/2022.10.22.513328 +I162Q,NP_000537:p.Ile162Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.94763,2.2060387134552,2.06769,2.596581241647089,2.00766,2.2721056208235444,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,E,-0.4073,0.9099,-22.239,-6.17096696338336,0.2661369884207849,Benign,0.9926,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328 +I162R,NP_000537:p.Ile162Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.76391,2.334740400314331,3.3551,3.313794672139156,4.559505,4.538852336069578,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,E,-0.4668,0.9099,-22.239,-5.69058193528002,0.6978860813106065,Pathogenic,0.9843,pathogenic,-4.05,available,https://doi.org/10.1101/2022.10.22.513328 +I162S,NP_000537:p.Ile162Ser,"hg19,17:g.7578445A>C, hg38,17:g.7675127A>C",,,0.865,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127813,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.06987,2.108771085739136,3.22585,3.744079678780408,3.1478599999999997,3.406974839390204,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,E,-0.3153,0.9099,-8.9511,-5.75718582247629,0.0534169987640842,Benign,0.9693,pathogenic,-3.764,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I162T,NP_000537:p.Ile162Thr,"hg19,17:g.7578445A>G, hg38,17:g.7675127A>G",,,0.798,"ClinVar,saturation_mutlist",1992967,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.93804,1.4656965732574463,1.91122,2.28940039156628,1.92463,2.1137201957831397,Neutral,Uncertain,Uncertain,Neutral,Uncertain,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,E,-0.2999,0.9099,-22.239,-5.75718582247629,0.5196488408575574,Uncertain,0.9144,pathogenic,-3.726,available,https://doi.org/10.1101/2022.10.22.513328 +I162V,NP_000537:p.Ile162Val,"hg19,17:g.7578446T>C, hg38,17:g.7675128T>C",,,0.498,"COSMIC,ClinVar,saturation_mutlist",1743548,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.85119,0.4518080949783325,0.54932,0.3472390937349806,0.7002550000000001,0.5992145468674903,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,E,-0.077,0.9099,-0.5042,-0.462147024394601,2.876198913679699e-09,Benign,0.0931,benign,-2.83,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I162W,NP_000537:p.Ile162Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.33159,1.46150541305542,1.43367,2.4936639100636966,4.88263,5.412626955031849,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,E,-0.3246,0.9099,-8.9511,-5.8430531674617,0.8045207572051666,Pathogenic,0.9929,pathogenic,-4.374,available,https://doi.org/10.1101/2022.10.22.513328 +I162Y,NP_000537:p.Ile162Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.65145,1.507427215576172,1.37619,2.556040292717866,5.01382,5.603745146358933,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.194,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,E,-0.4013,0.9099,-22.239,-5.8430531674617,0.7454748767414325,Pathogenic,0.9763,pathogenic,-4.182,available,https://doi.org/10.1101/2022.10.22.513328 +Y163A,NP_000537:p.Tyr163Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.31847,2.987548589706421,3.23912,4.143048548103534,3.278795,3.730759274051767,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.148,0.01506,,,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.442,0.1096,-22.2419,-7.83850975984194,0.8692588042206815,Pathogenic,0.9992,pathogenic,-4.482,available,https://doi.org/10.1101/2022.10.22.513328 +Y163C,NP_000537:p.Tyr163Cys,"hg19,17:g.7578442T>C, hg19,17:g.7675124T>C, hg38,17:g.7675124T>C",,,0.872,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127814,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,3.22054,2.212515354156494,3.14286,4.362625364423778,3.1817,3.7915826822118888,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.148,0.0536,-0.26643,Neutral,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.3448,0.1096,-8.9541,-7.83850975984194,0.4586809845101737,Uncertain,0.9824,pathogenic,-3.814,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y163D,NP_000537:p.Tyr163Asp,"hg19,17:g.7578443A>C, hg19,17:g.7675125A>C, hg38,17:g.7675125A>C",,,0.906,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",187052,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.14124,3.463131666183472,4.52993,4.925237191830757,4.335585,4.533238595915378,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.148,0.17854,0.0109,Neutral,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.4562,0.1096,-22.2419,-7.83850975984194,0.8692680938652717,Pathogenic,0.9992,pathogenic,-4.596,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y163E,NP_000537:p.Tyr163Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.71961,3.216704130172729,4.08163,4.415272764063845,3.90062,4.067441382031922,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.148,-0.0031,,,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.4849,0.1096,-22.2419,-7.83850975984194,0.8706025804523456,Pathogenic,0.9998,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328 +Y163F,NP_000537:p.Tyr163Phe,"hg19,17:g.7578442T>A",,,0.723,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.03853,0.6245543956756592,-0.77789,0.0058439383528197,-0.36968,0.02218696917640985,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.148,-0.1624,-0.12032,Neutral,,,,,,1.3,,False,1.3,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.85,E,-0.2015,0.1096,-6.9542,-2.74211411025487,0.0025652413863638,Benign,0.2372,benign,-3.306,available,https://doi.org/10.1101/2022.10.22.513328 +Y163G,NP_000537:p.Tyr163Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.88748,3.09910535812378,4.88299,5.901516224085907,4.885235,5.394498112042953,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.148,-0.0031,,,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.5125,0.1096,-22.2419,-7.83850975984194,0.8696756315287439,Pathogenic,0.9958,pathogenic,-4.59,available,https://doi.org/10.1101/2022.10.22.513328 +Y163H,NP_000537:p.Tyr163His,"hg19,17:g.7578443A>G, hg19,17:g.7675125A>G, hg38,17:g.7675125A>G",,,0.904,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376680,Pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.35527,2.0810210704803467,2.18776,2.115119537595931,2.271515,2.2351947687979656,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.148,0.02506,-0.18858,Neutral,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.3497,0.1096,-22.2419,-4.63018780181566,0.8549106552265939,Pathogenic,0.9929,pathogenic,-3.94,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y163I,NP_000537:p.Tyr163Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.10241,2.269248485565185,1.26054,2.3742796029851703,1.1814749999999998,1.738344801492585,Neutral,Uncertain,Destabilizing,Neutral,Neutral,False,0.148,0.06466,,,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.454,0.1096,-22.2419,-7.83850975984194,0.8663560522415912,Pathogenic,0.9983,pathogenic,-4.482,available,https://doi.org/10.1101/2022.10.22.513328 +Y163K,NP_000537:p.Tyr163Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.2644,2.884904384613037,3.12687,5.025795371363066,3.6956350000000002,4.645097685681533,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.148,0.15524,,,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.5102,0.1096,-22.2419,-7.83850975984194,0.8680679157940165,Pathogenic,0.9996,pathogenic,-4.616,available,https://doi.org/10.1101/2022.10.22.513328 +Y163L,NP_000537:p.Tyr163Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.08467,2.204517364501953,1.59286,1.6146233340940797,1.338765,1.3496466670470397,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.148,0.14702,,,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.3633,0.1096,-8.9541,-7.83850975984194,0.8571578588117306,Pathogenic,0.9894,pathogenic,-4.276,available,https://doi.org/10.1101/2022.10.22.513328 +Y163M,NP_000537:p.Tyr163Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.57857,2.350599765777588,1.55272,2.151883191933228,1.065645,1.365226595966614,Neutral,Uncertain,Destabilizing,Neutral,Neutral,False,0.148,-0.0098,,,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.3832,0.1096,-22.2419,-7.83850975984194,0.8547996128182295,Pathogenic,0.9977,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328 +Y163N,NP_000537:p.Tyr163Asn,"hg19,17:g.7578443A>T, hg19,17:g.7578443_7578444delinsTA, hg19,17:g.7675125A>T, hg38,17:g.7675125A>T",,,0.907,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376679,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.73582,2.9790663719177246,3.44116,3.886359091710331,3.08849,3.3110895458551655,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.148,0.011,-0.15812,Neutral,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.4352,0.1096,-22.2419,-7.83850975984194,0.8569736234526466,Pathogenic,0.9958,pathogenic,-4.412,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y163P,NP_000537:p.Tyr163Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.90146,2.558134078979492,3.31769,6.420084177977175,2.109575,3.6607720889885877,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,False,0.148,0.04592,,,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.5662,0.1096,-22.2419,-7.83850975984194,0.8696300503786667,Pathogenic,0.9985,pathogenic,-4.563,available,https://doi.org/10.1101/2022.10.22.513328 +Y163Q,NP_000537:p.Tyr163Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.58084,3.0778067111968994,3.05034,3.829638742030745,3.8155900000000003,4.205239371015373,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.148,0.0583,,,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.4597,0.1096,-22.2419,-7.83850975984194,0.8699101773433094,Pathogenic,0.9995,pathogenic,-4.413,available,https://doi.org/10.1101/2022.10.22.513328 +Y163R,NP_000537:p.Tyr163Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.33004,2.573411703109741,4.22585,3.912049641730428,5.277945000000001,5.121044820865214,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.148,0.09606,,,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.5055,0.1096,-22.2419,-7.83850975984194,0.8705766682395808,Pathogenic,0.9974,pathogenic,-4.454,available,https://doi.org/10.1101/2022.10.22.513328 +Y163S,NP_000537:p.Tyr163Ser,"hg19,17:g.7578442T>G, hg38,17:g.7675124T>G",,,0.901,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2757988,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.49365,3.183641195297241,4.00918,5.056159321272653,4.251415,4.774904660636326,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.148,0.07862,-0.22329,Neutral,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.4467,0.1096,-22.2419,-7.83850975984194,0.8701990254434995,Pathogenic,0.9949,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y163T,NP_000537:p.Tyr163Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.63758,2.847710609436035,3.31531,3.947121051071522,3.476445,3.7923505255357606,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.148,0.0741,,,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.4653,0.1096,-22.2419,-7.83850975984194,0.8684686729564621,Pathogenic,0.999,pathogenic,-4.472,available,https://doi.org/10.1101/2022.10.22.513328 +Y163V,NP_000537:p.Tyr163Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.71878,2.3624658584594727,1.39422,2.6425236484066748,1.5565,2.1806518242033373,Neutral,Uncertain,Destabilizing,Neutral,Uncertain,False,0.148,0.07902,,,,,,,,1.3,,False,1.3,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.85,E,-0.4436,0.1096,-22.2419,-7.83850975984194,0.8642682821084049,Pathogenic,0.9965,pathogenic,-4.432,available,https://doi.org/10.1101/2022.10.22.513328 +Y163W,NP_000537:p.Tyr163Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.11194,0.8877890110015869,2.4449,0.562787628729699,3.2784199999999997,2.337363814364849,Uncertain,Uncertain,Neutral,Destabilizing,Uncertain,False,0.148,-0.3288,,,,,,,,1.3,,False,1.3,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.85,E,-0.3595,0.1096,-22.2419,-4.70351320819519,0.870302303289236,Pathogenic,0.8813,pathogenic,-4.332,available,https://doi.org/10.1101/2022.10.22.513328 +K164A,NP_000537:p.Lys164Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.62933,0.433154284954071,0.27585,0.5843896679168015,0.9525899999999999,1.1068598339584006,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.3163,0.0678,-22.2419,-5.10596589958081,0.1391736952409238,Benign,0.9414,pathogenic,-4.004,available,https://doi.org/10.1101/2022.10.22.513328 +K164C,NP_000537:p.Lys164Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.63294,0.2038948535919189,1.11088,1.0933102753916382,1.3719100000000002,1.3631251376958191,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.3865,0.0678,-22.2419,-5.44896686250668,0.5013011992055324,Uncertain,0.9482,pathogenic,-4.21,available,https://doi.org/10.1101/2022.10.22.513328 +K164D,NP_000537:p.Lys164Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.19515,1.940029621124268,2.02925,1.0791763580259084,2.1122,1.6371631790129542,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.4253,0.0678,-22.2419,-6.9942592743991,0.837169630482437,Pathogenic,0.9935,pathogenic,-4.5,available,https://doi.org/10.1101/2022.10.22.513328 +K164E,NP_000537:p.Lys164Glu,"hg19,17:g.7578440T>C, hg19,17:g.7675122T>C, hg38,17:g.7675122T>C",,,0.875,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",246416,Pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.4276,1.2347416877746582,1.82041,0.7863645111095341,1.624005,1.106982255554767,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.3412,0.0678,-22.2419,-6.13403327025882,0.3646032755188367,Uncertain,0.9696,pathogenic,-4.122,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K164F,NP_000537:p.Lys164Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.26775,0.973464846611023,0.7102,0.1003972309867567,0.48897500000000005,0.18407361549337833,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.96,S,-0.3874,0.0678,-22.2419,-7.56538754350299,0.8669078559905607,Pathogenic,0.9952,pathogenic,-4.636,available,https://doi.org/10.1101/2022.10.22.513328 +K164G,NP_000537:p.Lys164Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.35686,1.2674986124038696,1.77619,1.4141755670311,2.066525,1.88551778351555,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.3755,0.0678,-22.2419,-7.82858939090521,0.7863547222567662,Pathogenic,0.9522,pathogenic,-4.28,available,https://doi.org/10.1101/2022.10.22.513328 +K164H,NP_000537:p.Lys164His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.01812,1.0453972816467283,1.02517,0.2875042539370304,1.521645,1.1528121269685152,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.3264,0.0678,-22.2419,-7.56538754350299,0.8675117059848358,Pathogenic,0.8487,pathogenic,-4.33,available,https://doi.org/10.1101/2022.10.22.513328 +K164I,NP_000537:p.Lys164Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.69337,0.0429713726043701,1.47823,-0.2599954303872565,1.0857999999999999,0.21668728480637178,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.96,S,-0.3546,0.0678,-22.2419,-5.96296308666808,0.5449997164933468,Uncertain,0.9769,pathogenic,-4.347,available,https://doi.org/10.1101/2022.10.22.513328 +K164L,NP_000537:p.Lys164Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.14406,-0.0101183652877807,1.55136,-0.7291615103008292,0.70365,-0.4366107551504146,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.96,S,-0.3533,0.0678,-22.2419,-5.07410976626896,0.503376901087779,Uncertain,0.9306,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328 +K164M,NP_000537:p.Lys164Met,"hg19,17:g.7578439T>A, hg38,17:g.7675121T>A",,,0.925,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.09675,0.0843157768249511,1.04456,0.0049194141412256,0.5706549999999999,0.0508347070706128,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.3264,0.0678,-22.2419,-4.95330904216767,0.2508344765534155,Benign,0.901,pathogenic,-4.007,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K164N,NP_000537:p.Lys164Asn,"hg19,17:g.7578438C>A, hg19,17:g.7578438C>G, hg19,17:g.7675120C>A, hg38,17:g.7675120C>A, hg38,17:g.7675120C>G",,,0.794,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2848594, 428899","Uncertain significance, Uncertain significance","1, 1",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.34421,1.1344687938690186,1.1898,0.4763147212666652,1.767005,1.4102623606333324,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.3345,0.0678,-22.2419,-6.9942592743991,0.7698240855821997,Pathogenic,0.983,pathogenic,-4.238,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K164P,NP_000537:p.Lys164Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.16472,1.9306045770645144,4.00136,5.079875736318947,5.5830400000000004,6.122297868159473,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.4906,0.0678,-22.2419,-7.82858939090521,0.7722193709959284,Pathogenic,0.9931,pathogenic,-4.366,available,https://doi.org/10.1101/2022.10.22.513328 +K164Q,NP_000537:p.Lys164Gln,"hg19,17:g.7578440T>G, hg38,17:g.7675122T>G",,,0.899,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2687712,Uncertain significance,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.05046,0.3593771457672119,0.85102,0.4898996837649044,0.9507399999999999,0.7701798418824521,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.3155,0.0678,-22.2419,-4.46414505079612,0.6164651683915742,Uncertain,0.5962,pathogenic,-3.98,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K164R,NP_000537:p.Lys164Arg,"hg19,17:g.7578439T>C, hg38,17:g.7675121T>C",,,0.906,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.80901,0.1557093858718872,1.13435,0.0352808202809024,0.97168,0.4221454101404512,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.96,S,-0.1719,0.0678,-6.9542,-1.79641753144727,0.0029539731212726,Benign,0.1385,benign,-3.382,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K164S,NP_000537:p.Lys164Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.41329,0.6283509135246277,1.16497,1.0018209680275465,1.78913,1.7075554840137732,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.3264,0.0678,-22.2419,-5.05904966575694,0.0382170755871565,Benign,0.9419,pathogenic,-3.776,available,https://doi.org/10.1101/2022.10.22.513328 +K164T,NP_000537:p.Lys164Thr,"hg19,17:g.7578439T>G, hg38,17:g.7675121T>G",,,0.927,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.87897,0.4354825019836426,2.40068,0.5925597724342071,2.139825,1.2357648862171036,Uncertain,Neutral,Neutral,Uncertain,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.3383,0.0678,-22.2419,-4.89004485921964,0.3095712567729934,Benign,0.8969,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +K164V,NP_000537:p.Lys164Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.63795,0.1682523488998413,-1.5551,-0.0891246726747452,-0.45857499999999995,0.2744126636626274,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.96,S,-0.3385,0.0678,-22.2419,-6.17425991523464,0.5084372117824716,Uncertain,0.952,pathogenic,-4.123,available,https://doi.org/10.1101/2022.10.22.513328 +K164W,NP_000537:p.Lys164Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.90135,1.02975594997406,0.83163,-0.2200256289946761,0.86649,0.3406621855026619,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.96,S,-0.3964,0.0678,-22.2419,-7.56538754350299,0.8274083640378417,Pathogenic,0.9896,pathogenic,-4.558,available,https://doi.org/10.1101/2022.10.22.513328 +K164Y,NP_000537:p.Lys164Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48467,1.0577930212020874,0.54728,0.2703732077704135,0.515975,0.3775216038852067,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.065,,,Uncertain,,Uncertain,,,Uncertain,55.9,,False,55.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.96,S,-0.3723,0.0678,-22.2419,-7.56538754350299,0.8680802653289659,Pathogenic,0.9784,pathogenic,-4.503,available,https://doi.org/10.1101/2022.10.22.513328 +Q165A,NP_000537:p.Gln165Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.31073,0.0417598485946655,-0.07517,0.6359585284484409,0.11778,0.4733442642242205,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.0418,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.5,S,-0.2507,0.5346,-22.239,-4.6221152236935,5.868975472295857e-06,Benign,0.3009,benign,-3.106,available,https://doi.org/10.1101/2022.10.22.513328 +Q165C,NP_000537:p.Gln165Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.36799,-0.3643918633460998,0.49762,1.0309616329225262,0.432805,0.6994758164612631,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.01526,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.5,S,-0.2969,0.5346,-22.239,-4.94605015438188,2.028080132610777e-07,Benign,0.8166,pathogenic,-3.118,available,https://doi.org/10.1101/2022.10.22.513328 +Q165D,NP_000537:p.Gln165Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.37901,-0.3458204865455627,-0.17109,0.5416687359093916,0.10396000000000001,0.46033936795469577,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.03208,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.5,S,-0.3372,0.5346,-22.239,-3.82900690144397,1.187126582962172e-06,Benign,0.6544,pathogenic,-3.097,available,https://doi.org/10.1101/2022.10.22.513328 +Q165E,NP_000537:p.Gln165Glu,"hg19,17:g.7578437G>C, hg38,17:g.7675119G>C",,,0.572,"COSMIC,ClinVar,saturation_mutlist",3634431,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.14645,-0.485413134098053,-0.29592,0.3200994461631712,-0.22118500000000002,0.0868247230815856,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.01386,-0.16494,Neutral,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.5,S,-0.188,0.5346,-8.9511,-3.79832456836452,9.176279346988106e-08,Benign,0.238,benign,-2.951,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q165F,NP_000537:p.Gln165Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.88078,-0.0926429033279419,-0.20442,-0.1750679221015566,-0.5426,-0.5279239610507783,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,0.06938,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.5,S,-0.3049,0.5346,-22.239,-5.91989421718138,0.0001193992474123,Benign,0.8864,pathogenic,-3.488,available,https://doi.org/10.1101/2022.10.22.513328 +Q165G,NP_000537:p.Gln165Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42957,0.4643565416336059,1.32007,1.6017562043357907,1.3748200000000002,1.5156631021678955,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.09234,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.5,S,-0.3213,0.5346,-22.239,-4.12485339031954,1.245270409518038e-07,Benign,0.4131,ambiguous,-3.096,available,https://doi.org/10.1101/2022.10.22.513328 +Q165H,NP_000537:p.Gln165His,"hg19,17:g.7578435C>A, hg38,17:g.7675117C>A, hg38,17:g.7675117C>G",,,0.600,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01558,-0.1520566940307617,0.11735,0.0125456503342391,0.050885,-0.00151717483288045,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.01124,-0.14216,Neutral,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.5,S,-0.2518,0.5346,-22.239,-5.91989421718138,1.6049705327078507e-05,Benign,0.3948,ambiguous,-3.229,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q165I,NP_000537:p.Gln165Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.70386,-0.1464446783065796,-0.72993,-0.1789247843260483,-0.7168950000000001,-0.44139239216302417,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.01948,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.5,S,-0.2863,0.5346,-22.239,-4.61721972138562,2.4726695642988905e-05,Benign,0.7338,pathogenic,-3.296,available,https://doi.org/10.1101/2022.10.22.513328 +Q165K,NP_000537:p.Gln165Lys,"hg19,17:g.7578437G>T, hg38,17:g.7675119G>T",,,0.481,"cBioPortal,ClinVar,saturation_mutlist",482232,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.57892,0.3080401718616485,0.29184,0.4387124276290349,-0.14354,-0.07010378618548255,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,0.05368,0.12423,Neutral,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.5,S,-0.171,0.5346,-0.1311,0.597145055795084,1.595742701002255e-23,Benign,0.1186,benign,-2.698,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q165L,NP_000537:p.Gln165Leu,"hg19,17:g.7578436T>A, hg38,17:g.7675118T>A",,,0.574,"COSMIC,ClinVar,saturation_mutlist",2505496,Pathogenic,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.15967,-0.0808661580085754,-0.92993,-0.4868549529232879,-1.0448,-0.823262476461644,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,0.0008,0.03021,Neutral,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.5,S,-0.2696,0.5346,-22.239,-3.1479277378225,4.5110084836118185e-08,Benign,0.2476,benign,-3.032,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q165M,NP_000537:p.Gln165Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.23288,0.0034683942794799,-0.38912,-0.0953844942747644,-0.8109999999999999,-0.6641322471373822,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,0.02272,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.5,S,-0.2406,0.5346,-22.239,-4.45370527071802,5.094235296928069e-06,Benign,0.4253,ambiguous,-3.177,available,https://doi.org/10.1101/2022.10.22.513328 +Q165N,NP_000537:p.Gln165Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.55934,-0.013981819152832,0.07517,0.3127223523837863,0.31725499999999995,0.43603117619189313,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.0109,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.5,S,-0.1985,0.5346,-8.9511,-0.728888358913719,1.226965580192127e-12,Benign,0.3741,ambiguous,-2.838,available,https://doi.org/10.1101/2022.10.22.513328 +Q165P,NP_000537:p.Gln165Pro,"hg38,17:g.7675118T>G",,,0.653,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.12513,0.4365733563899994,2.19082,1.932776490782649,0.532845,0.4038232453913245,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.046,0.19946,-0.01672,Neutral,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.5,S,-0.4243,0.5346,-22.239,-6.30577079745317,0.0004309376365346,Benign,0.5766,pathogenic,-3.41,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q165R,NP_000537:p.Gln165Arg,"hg38,17:g.7675118T>C",,,0.475,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.51985,0.3430471420288086,0.33878,0.1578610949678949,-0.090535,-0.18099445251605256,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.12114,-0.64288,Neutral,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.5,S,-0.1993,0.5346,-5.9513,-0.744174817524804,2.855191870853627e-13,Benign,0.2235,benign,-2.686,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q165S,NP_000537:p.Gln165Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.90008,0.0363464951515197,0.50034,0.9231389359205944,0.70021,0.9116094679602972,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.03284,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.5,S,-0.1962,0.5346,-7.9512,-3.25589551056651,7.583367232924971e-10,Benign,0.3367,benign,-2.905,available,https://doi.org/10.1101/2022.10.22.513328 +Q165T,NP_000537:p.Gln165Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.85299,0.0160651803016662,0.28639,0.4660766035858948,0.56969,0.6595333017929474,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.02096,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.5,S,-0.279,0.5346,-22.239,-4.49684013715844,2.6779692222751912e-06,Benign,0.3102,benign,-3.016,available,https://doi.org/10.1101/2022.10.22.513328 +Q165V,NP_000537:p.Gln165Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.16583,-0.0351295471191406,-0.33061,-0.0736838562919717,-0.24822,-0.11975692814598585,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.1452,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,94.5,S,-0.2864,0.5346,-22.239,-4.73702447938161,1.879993012737302e-05,Benign,0.5143,ambiguous,-3.244,available,https://doi.org/10.1101/2022.10.22.513328 +Q165W,NP_000537:p.Gln165Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.95043,-0.0539371371269226,-0.4466,-0.4862856300297047,-0.698515,-0.7183578150148524,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.04528,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.5,S,-0.3043,0.5346,-22.239,-5.91989421718138,0.002444726602777,Benign,0.8866,pathogenic,-3.536,available,https://doi.org/10.1101/2022.10.22.513328 +Q165Y,NP_000537:p.Gln165Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.82334,-0.1874310970306396,-0.34728,-0.0975831075458777,-0.58531,-0.46046155377293885,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.046,-0.09304,,Uncertain,,Uncertain,,,Uncertain,55.1,,False,55.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.5,S,-0.3072,0.5346,-22.239,-5.91989421718138,3.5163131553633387e-06,Benign,0.7491,pathogenic,-3.322,available,https://doi.org/10.1101/2022.10.22.513328 +S166A,NP_000537:p.Ser166Ala,"hg19,17:g.7578434A>C, hg38,17:g.7675116A>C",,,0.487,"COSMIC,ClinVar,saturation_mutlist",2687713,Uncertain significance,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.36484,-0.0509061217308044,-0.15816,-0.3743373749461676,-0.2615,-0.3695886874730838,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,0.3861,-0.0892,Neutral,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,92.99,G,-0.0352,1.4753,-0.7705,-1.6681715036531,0.000147551899433,Benign,0.0945,benign,-3.0,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S166C,NP_000537:p.Ser166Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.12738,0.0225659608840942,0.86054,0.5482424929473567,0.49395999999999995,0.33781124647367833,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,0.11174,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.1274,1.4753,-8.9453,-1.66978399331955,0.2685763719008316,Benign,0.3307,benign,-3.808,available,https://doi.org/10.1101/2022.10.22.513328 +S166D,NP_000537:p.Ser166Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.19095,0.4732768535614013,-0.11973,-0.6065811327060766,-0.15534,-0.3987655663530383,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,-0.10814,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.2434,1.4753,-22.2332,-4.83317350903605,0.0795670691728424,Benign,0.8878,pathogenic,-3.689,available,https://doi.org/10.1101/2022.10.22.513328 +S166E,NP_000537:p.Ser166Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.62742,0.0688948631286621,-0.42653,-0.7483078121608189,-0.526975,-0.6878639060804095,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,0.0644,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.2166,1.4753,-22.2332,-4.96003878416074,0.1591370218912332,Benign,0.8608,pathogenic,-3.746,available,https://doi.org/10.1101/2022.10.22.513328 +S166F,NP_000537:p.Ser166Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.45459,0.3953815102577209,-0.2432,-0.6078089922019014,-0.348895,-0.5311994961009507,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,0.11164,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.2228,1.4753,-22.2332,-5.72708266180734,0.4638692962826835,Uncertain,0.5969,pathogenic,-3.948,available,https://doi.org/10.1101/2022.10.22.513328 +S166G,NP_000537:p.Ser166Gly,"hg38,17:g.7675115_7675116delinsCC",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.03491,0.3894771039485931,0.55986,0.0327848733842267,0.297385,0.03384743669211335,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,-0.16022,-0.03964,Neutral,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,DOWN,neutral,neutral,False,neutral,neutral,92.99,G,-0.1539,1.4753,-22.2332,-6.3247105867852,0.7514509966966355,Pathogenic,0.3208,benign,-3.823,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S166H,NP_000537:p.Ser166His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.0054,0.077442467212677,-0.14286,-0.7730724376956383,-0.07412999999999999,-0.3892362188478191,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,0.11174,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.224,1.4753,-22.2332,-5.07831126174798,0.2524368444732401,Benign,0.7686,pathogenic,-3.711,available,https://doi.org/10.1101/2022.10.22.513328 +S166I,NP_000537:p.Ser166Ile,"hg38,17:g.7675114_7675116delinsGAT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.39286,0.2007105350494384,-0.36837,-0.5294303258960886,-0.380615,-0.4611451629480443,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,-0.08736,-0.00164,Neutral,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.1581,1.4753,-8.9453,-3.49392141879354,0.312513367970137,Benign,0.5185,ambiguous,-3.863,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S166K,NP_000537:p.Ser166Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.45514,-0.1199759244918823,-0.59252,-0.5616971163459922,-0.52383,-0.5084185581729961,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,-0.02366,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.2333,1.4753,-22.2332,-6.3247105867852,0.815608427253362,Pathogenic,0.9574,pathogenic,-3.982,available,https://doi.org/10.1101/2022.10.22.513328 +S166L,NP_000537:p.Ser166Leu,"hg19,17:g.7578433G>A, hg38,17:g.7675115G>A",,,0.613,"COSMIC,ClinVar,saturation_mutlist",528239,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.57767,0.2860398292541504,-0.75272,-1.0337157130580714,-0.665195,-0.8056928565290358,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,0.00078,0.11427,Neutral,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.1361,1.4753,-5.3605,-1.83955355180868,5.412090413575097e-05,Benign,0.1355,benign,-3.348,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S166M,NP_000537:p.Ser166Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.72476,0.2640259265899658,-0.61463,-0.6241730352719688,-0.6696949999999999,-0.6744665176359843,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,-0.11984,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.1932,1.4753,-22.2332,-5.12945473682947,0.4403665723890536,Uncertain,0.2784,benign,-3.774,available,https://doi.org/10.1101/2022.10.22.513328 +S166N,NP_000537:p.Ser166Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.0405,0.239130437374115,-0.40578,-0.5014594142837187,-0.18264,-0.23047970714185934,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,0.11168,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.167,1.4753,-22.2332,-5.21572547745391,0.3342154321828632,Uncertain,0.5809,pathogenic,-3.66,available,https://doi.org/10.1101/2022.10.22.513328 +S166P,NP_000537:p.Ser166Pro,"hg38,17:g.7675116A>G",,,0.707,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-2.00934,-0.2609020471572876,-0.9568,-0.0151005269218512,-1.4830699999999999,-1.0122202634609256,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.037,0.11172,0.11411,Neutral,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.216,1.4753,-6.1381,-2.90524947974682,0.0001486018049043,Benign,0.3253,benign,-3.253,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S166Q,NP_000537:p.Ser166Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.3507,-0.0268200039863586,-0.59354,-0.3880533357381127,-0.47212,-0.3693766678690563,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,0.1117,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.1866,1.4753,-22.2332,-5.21572547745391,0.5059740437916836,Uncertain,0.7497,pathogenic,-3.823,available,https://doi.org/10.1101/2022.10.22.513328 +S166R,NP_000537:p.Ser166Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.35041,-0.0018600225448608,-0.16599,-0.6178961191597043,-0.2582,-0.48415305957985216,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,-0.05788,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.2386,1.4753,-22.2332,-6.3247105867852,0.6705894350091829,Uncertain,0.9586,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328 +S166T,NP_000537:p.Ser166Thr,"hg19,17:g.7578434A>T, hg38,17:g.7675116A>T",,,0.512,"COSMIC,ClinVar,saturation_mutlist",3809673,Likely benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.08995,0.2628198266029358,0.33197,-0.3845417385202548,0.12100999999999999,-0.23724586926012742,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,-0.02392,0.06493,Neutral,,Uncertain,,,Uncertain,97.5,,False,97.5,,neutral,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.0425,1.4753,-4.0386,-1.79366907215294,5.393523103078352e-05,Benign,0.157,benign,-3.18,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S166V,NP_000537:p.Ser166Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.0993,0.2614743709564209,0.35748,-0.4378288886578901,0.12909,-0.26856444432894505,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,-0.05288,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.2002,1.4753,-22.2332,-5.12945473682947,0.3066744558141589,Benign,0.3909,ambiguous,-3.791,available,https://doi.org/10.1101/2022.10.22.513328 +S166W,NP_000537:p.Ser166Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.70716,0.2885344624519348,-0.37585,-1.0351634624841877,-0.541505,-0.8711617312420938,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,0.11168,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.2325,1.4753,-22.2332,-5.72708266180734,0.7556672233700359,Pathogenic,0.6894,pathogenic,-4.211,available,https://doi.org/10.1101/2022.10.22.513328 +S166Y,NP_000537:p.Ser166Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.42897,0.2325621247291565,-0.42891,-0.5915444740119596,-0.42894,-0.5102572370059798,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,0.11166,,Uncertain,,Uncertain,,,Uncertain,97.5,,False,97.5,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,92.99,G,-0.2276,1.4753,-22.2332,-5.03590427425324,0.1766604311795214,Benign,0.5873,pathogenic,-3.878,available,https://doi.org/10.1101/2022.10.22.513328 +Q167A,NP_000537:p.Gln167Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.33335,-0.1089711189270019,-0.14014,0.0285460425938283,-0.23674499999999998,-0.15240197870308583,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.826,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2297,0.7627,-22.2419,-5.05240105698553,0.0027501768451349,Benign,0.2839,benign,-3.22,available,https://doi.org/10.1101/2022.10.22.513328 +Q167C,NP_000537:p.Gln167Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.02844,-0.0035263299942016,0.58537,0.5520367426989672,0.306905,0.2902383713494836,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.75632,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2759,0.7627,-22.2419,-5.5948838562905,0.2353664813145259,Benign,0.883,pathogenic,-3.712,available,https://doi.org/10.1101/2022.10.22.513328 +Q167D,NP_000537:p.Gln167Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.02891,0.0706785321235656,-0.07483,0.1342955518082011,-0.05187,0.05269277590410055,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.37442,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2341,0.7627,-6.1468,-2.00908986839085,1.5345097554704166e-08,Benign,0.6807,pathogenic,-2.86,available,https://doi.org/10.1101/2022.10.22.513328 +Q167E,NP_000537:p.Gln167Glu,"hg38,17:g.7675113G>C",,,0.467,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.31186,-0.2132153511047363,0.08265,-0.0776508081044335,-0.11460500000000001,-0.19475540405221675,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,-0.06476,0.2131,Neutral,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.1226,0.7627,-0.2468,-0.362404426258414,6.128985523826569e-13,Benign,0.0935,benign,-2.658,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q167F,NP_000537:p.Gln167Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.08241,0.5031695365905762,0.62313,-0.3213846855098196,0.27036,-0.20189734275490978,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.29406,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2839,0.7627,-22.2419,-6.36881646439402,0.2201780926149382,Benign,0.9381,pathogenic,-3.846,available,https://doi.org/10.1101/2022.10.22.513328 +Q167G,NP_000537:p.Gln167Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.24158,0.278026819229126,0.79694,0.7936655701093365,0.5192599999999999,0.5176227850546682,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,1.02466,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2326,0.7627,-8.9541,-4.90006830275617,0.000237491982194,Benign,0.466,ambiguous,-3.283,available,https://doi.org/10.1101/2022.10.22.513328 +Q167H,NP_000537:p.Gln167His,"hg19,17:g.7578429C>A, hg19,17:g.7578429C>G, hg38,17:g.7675111C>A, hg38,17:g.7675111C>G",,,"0.589, 0.592","cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.18276,0.1535145044326782,0.35034,-0.3118057326835755,0.26655,-0.06452286634178774,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.29636,0.00413,Neutral,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2308,0.7627,-22.2419,-6.04298878400287,0.0021673175787741,Benign,0.5183,ambiguous,-3.251,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q167I,NP_000537:p.Gln167Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.40153,0.4151275753974914,0.41633,-0.2986164949583714,0.00739999999999999,-0.35007324747918567,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.27356,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2653,0.7627,-22.2419,-6.48335161373988,0.1760475847152851,Benign,0.6934,pathogenic,-3.662,available,https://doi.org/10.1101/2022.10.22.513328 +Q167K,NP_000537:p.Gln167Lys,"hg19,17:g.7578431G>T, hg38,17:g.7675113G>T",,,0.647,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2736423,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.52478,0.2601178884506225,-0.4034,-0.2135241530583165,-0.46409,-0.36915207652915827,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.66548,0.25535,Neutral,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2629,0.7627,-22.2419,-6.65723665606982,0.0080379362292281,Benign,0.3089,benign,-3.526,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q167L,NP_000537:p.Gln167Leu,"hg38,17:g.7675112T>A",,,0.569,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.04839,0.4299022555351257,-0.44694,-0.4933842352967543,-0.247665,-0.27088711764837714,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,-0.0085,-0.2344,Neutral,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2487,0.7627,-22.2419,-6.48335161373988,0.0981542411945038,Benign,0.3813,ambiguous,-3.654,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q167M,NP_000537:p.Gln167Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.5058,0.3249032497406006,0.2449,-0.2182790972212622,-0.13045,-0.36203954861063115,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,-0.51258,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2196,0.7627,-22.2419,-6.48335161373988,0.0448589465979961,Benign,0.5716,pathogenic,-3.578,available,https://doi.org/10.1101/2022.10.22.513328 +Q167N,NP_000537:p.Gln167Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.10947,0.2574321627616882,0.01735,0.0311752966735595,0.06341,0.07032264833677974,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.0768,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2454,0.7627,-22.2419,-3.43255365511228,0.0005376168063681,Benign,0.4789,ambiguous,-3.236,available,https://doi.org/10.1101/2022.10.22.513328 +Q167P,NP_000537:p.Gln167Pro,"hg19,17:g.7578430T>G, hg38,17:g.7675112T>G",3.18735258494e-05,,0.633,"ClinVar,saturation_mutlist",490173,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.57856,0.3574351668357849,3.09184,2.581921326504062,1.25664,1.001680663252031,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.027,0.61226,0.08169,Neutral,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.4033,0.7627,-22.2419,-7.03120427913244,0.318063924172586,Benign,0.287,benign,-3.588,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q167R,NP_000537:p.Gln167Arg,"hg19,17:g.7578430T>C, hg38,17:g.7675112T>C",,,0.566,"COSMIC,ClinVar,saturation_mutlist",653104,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.26124,0.3506733775138855,0.1432,-0.4342827686580208,-0.05902000000000002,-0.3477613843290104,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,-0.1776,-0.01699,Neutral,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.1936,0.7627,-8.9541,-6.23323076244701,0.0006004832881894,Benign,0.3113,benign,-3.294,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q167S,NP_000537:p.Gln167Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.02245,-0.1322919130325317,0.11871,0.1945089544544409,0.07058,0.10847947722722046,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.70642,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.1722,0.7627,-7.3692,-3.27845643129039,0.0002277684968011,Benign,0.3445,ambiguous,-3.088,available,https://doi.org/10.1101/2022.10.22.513328 +Q167T,NP_000537:p.Gln167Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.46983,0.2058085203170776,0.53844,-0.0069129094693054,0.504135,0.23145854526534732,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.78166,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2581,0.7627,-22.2419,-4.799030939519,0.0023535444557513,Benign,0.3604,ambiguous,-3.313,available,https://doi.org/10.1101/2022.10.22.513328 +Q167V,NP_000537:p.Gln167Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01377,0.4342820644378662,0.42619,-0.2137048214481113,0.20621,-0.11373741072405565,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.7013,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.51,G,-0.2654,0.7627,-22.2419,-5.97060422663239,0.1068066770839584,Benign,0.4895,ambiguous,-3.376,available,https://doi.org/10.1101/2022.10.22.513328 +Q167W,NP_000537:p.Gln167Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.23079,0.3893601894378662,0.44082,-0.7574064381728995,0.105015,-0.4940982190864498,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,-0.02926,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2833,0.7627,-22.2419,-6.36881646439402,0.1905905899709199,Benign,0.9049,pathogenic,-3.904,available,https://doi.org/10.1101/2022.10.22.513328 +Q167Y,NP_000537:p.Gln167Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.06299,0.3827969431877136,0.05204,-0.2824022252367092,-0.005475000000000001,-0.1726961126183546,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.27198,,Uncertain,,Uncertain,,,Uncertain,78.5,,False,78.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.51,G,-0.2862,0.7627,-22.2419,-6.36881646439402,0.2522644223292603,Benign,0.8878,pathogenic,-3.818,available,https://doi.org/10.1101/2022.10.22.513328 +H168A,NP_000537:p.His168Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.13521,1.162156581878662,0.85714,1.0986273667445725,0.996175,1.1169186833722864,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.029,0.0041,,,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,93.35,G,-0.2584,0.4206,-22.2419,-5.86696975564203,0.5420297420236151,Uncertain,0.9222,pathogenic,-4.106,available,https://doi.org/10.1101/2022.10.22.513328 +H168C,NP_000537:p.His168Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.86738,0.5104629993438721,1.16667,1.325018890647882,1.517025,1.596199445323941,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,-0.3286,,,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,93.35,G,-0.3129,0.4206,-22.2419,-6.18696950119922,0.836989219904867,Pathogenic,0.5888,pathogenic,-4.149,available,https://doi.org/10.1101/2022.10.22.513328 +H168D,NP_000537:p.His168Asp,"hg38,17:g.7675110G>C",,,0.551,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2902,1.6400370597839355,1.37347,1.572996074312714,0.541635,0.641398037156357,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.029,-0.18938,-0.97631,Neutral,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,93.35,G,-0.2297,0.4206,-7.3692,-3.20664808123884,0.0009146526920434,Benign,0.6778,pathogenic,-3.703,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H168E,NP_000537:p.His168Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.32319,1.403142333030701,2.28197,1.485752785519408,1.3025799999999998,0.9044713927597039,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.029,-0.02554,,,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,93.35,G,-0.3171,0.4206,-22.2419,-5.59248666879771,0.8286014951367308,Pathogenic,0.9297,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328 +H168F,NP_000537:p.His168Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.25899,0.0236052274703979,-0.62347,-0.5060388065919047,-0.44123,-0.3825144032959523,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,-0.69924,,,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,G,-0.1945,0.4206,-5.4948,-0.474417244883146,0.0105351595136972,Benign,0.304,benign,-3.64,available,https://doi.org/10.1101/2022.10.22.513328 +H168G,NP_000537:p.His168Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.03576,1.1068729162216189,1.90612,2.3760110581703264,1.97094,2.205885529085163,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,False,0.029,0.2396,,,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,93.35,G,-0.3409,0.4206,-22.2419,-7.23727323630724,0.8215326963108431,Pathogenic,0.9164,pathogenic,-4.34,available,https://doi.org/10.1101/2022.10.22.513328 +H168I,NP_000537:p.His168Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.23792,1.5623172521591189,0.46803,0.4584877703815182,0.352975,0.3482038851907591,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.029,-0.22374,,,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,G,-0.3446,0.4206,-22.2419,-6.75123843329861,0.8704798263868494,Pathogenic,0.9492,pathogenic,-4.437,available,https://doi.org/10.1101/2022.10.22.513328 +H168K,NP_000537:p.His168Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.4077,1.2053747177124023,1.43095,1.4209200165723943,0.919325,0.9143100082861971,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.029,0.18192,,,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,G,-0.3013,0.4206,-22.2419,-6.60908236639589,0.8222713856449133,Pathogenic,0.9385,pathogenic,-4.096,available,https://doi.org/10.1101/2022.10.22.513328 +H168L,NP_000537:p.His168Leu,"hg19,17:g.7578427T>A, hg19,17:g.7675109T>A, hg38,17:g.7675109T>A",,,0.550,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1744933,Pathogenic,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,-0.09936,1.1941208839416504,1.49014,0.1968029131646403,0.69539,0.04872145658232015,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.029,-0.31058,0.63572,Neutral,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,G,-0.3082,0.4206,-22.2419,-6.60832493435264,0.7549936755082538,Pathogenic,0.7531,pathogenic,-4.002,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H168M,NP_000537:p.His168Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48243,0.9158170223236084,1.36871,0.6294647774133572,0.92557,0.5559473887066786,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,-0.70554,,,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,G,-0.2583,0.4206,-22.2419,-6.75123843329861,0.8512185381819232,Pathogenic,0.922,pathogenic,-4.342,available,https://doi.org/10.1101/2022.10.22.513328 +H168N,NP_000537:p.His168Asn,"hg19,17:g.7578428G>T, hg38,17:g.7675110G>T",,,0.566,"COSMIC,ClinVar,saturation_mutlist",2687697,Uncertain significance,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.20665,1.0235393047332764,1.07619,0.8166458600225812,0.64142,0.5116479300112906,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.029,0.02718,-0.07916,Neutral,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,93.35,G,-0.2651,0.4206,-22.2419,-4.72985914704594,0.1486518005591041,Benign,0.4148,ambiguous,-3.688,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H168P,NP_000537:p.His168Pro,"hg19,17:g.7578426_7578427delinsCG, hg19,17:g.7578427T>G, hg19,17:g.7675109T>G, hg38,17:g.7675109T>G",,,0.526,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3328154,Likely pathogenic,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,3.42664,1.8685020208358765,5.88231,4.518457909903584,4.654475,3.972548954951792,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.029,-0.13088,0.16241,Neutral,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,93.35,G,-0.4216,0.4206,-22.2419,-7.23727323630724,0.8676805747380067,Pathogenic,0.9646,pathogenic,-4.254,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H168Q,NP_000537:p.His168Gln,"hg19,17:g.7578426G>C, hg19,17:g.7578426G>T, hg19,17:g.7675108G>C, hg38,17:g.7675108G>C, hg38,17:g.7675108G>T",,,0.568,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1745001,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.84543,0.973142147064209,1.32993,1.2513908210689866,1.08768,1.0484104105344934,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,0.3041,0.74195,Neutral,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,93.35,G,-0.2266,0.4206,-22.2419,-5.46615266747081,0.4951019121086106,Uncertain,0.8384,pathogenic,-3.718,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H168R,NP_000537:p.His168Arg,"hg19,17:g.7578426_7578427delinsTC, hg19,17:g.7578427T>C, hg19,17:g.7675109T>C, hg38,17:g.7675109T>C",,,0.562,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428866,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.13553,1.0186524391174316,1.50034,0.8692860228475787,1.3179349999999999,1.0024080114237894,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.029,-0.0602,0.40737,Neutral,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,G,-0.2947,0.4206,-22.2419,-3.66624520956463,0.7544042602940518,Pathogenic,0.8669,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H168S,NP_000537:p.His168Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.13986,1.242857575416565,1.55986,1.662383271935405,1.34986,1.4011216359677026,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.029,0.05202,,,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,93.35,G,-0.2643,0.4206,-22.2419,-5.62823134186807,0.4313199013049166,Uncertain,0.8036,pathogenic,-3.88,available,https://doi.org/10.1101/2022.10.22.513328 +H168T,NP_000537:p.His168Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.4409,1.3527271747589111,1.11259,1.1340716051898991,0.776745,0.7874858025949496,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.029,0.2613,,,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,93.35,G,-0.3092,0.4206,-22.2419,-6.18696950119922,0.7245305599908903,Pathogenic,0.9415,pathogenic,-4.281,available,https://doi.org/10.1101/2022.10.22.513328 +H168V,NP_000537:p.His168Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.87417,1.5816898345947266,0.16293,0.4363760146751155,0.51855,0.6552730073375578,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.029,-0.24372,0.20674,Neutral,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,93.35,G,-0.301,0.4206,-22.2419,-6.41564740878293,0.7516366221533969,Pathogenic,0.9113,pathogenic,-4.191,available,https://doi.org/10.1101/2022.10.22.513328 +H168W,NP_000537:p.His168Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.53913,0.2042769193649292,0.77585,-0.4780493694142518,0.65749,0.0305403152928741,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,-0.61952,,,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,G,-0.2963,0.4206,-22.2419,-4.0859338287686,0.7395136862693565,Pathogenic,0.5773,pathogenic,-4.218,available,https://doi.org/10.1101/2022.10.22.513328 +H168Y,NP_000537:p.His168Tyr,"hg19,17:g.7578428G>A, hg38,17:g.7675110G>A",,,0.501,"COSMIC,ClinVar,saturation_mutlist",4552487,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.0779,-0.5125875473022461,-0.67041,-0.2931862121046619,-0.37415499999999996,-0.18554310605233093,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.029,-0.43716,-0.15853,Neutral,,,,,,21.5,,True,21.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,G,-0.1415,0.4206,-4.8667,-0.238274744609607,0.0033759433076676,Benign,0.1263,benign,-3.41,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M169A,NP_000537:p.Met169Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.17042,0.220908522605896,0.71871,1.7320527341666718,0.944565,1.451236367083336,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.09236,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.2481,0.9321,-8.9541,-3.99597960154925,0.0027815006924094,Benign,0.7727,pathogenic,-3.365,available,https://doi.org/10.1101/2022.10.22.513328 +M169C,NP_000537:p.Met169Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.13753,0.3784416913986206,1.17483,2.116725286514052,1.15618,1.6271276432570259,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.05,0.02232,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.3214,0.9321,-22.2419,-5.6705964229845,0.7608210513954525,Pathogenic,0.8643,pathogenic,-3.91,available,https://doi.org/10.1101/2022.10.22.513328 +M169D,NP_000537:p.Met169Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.45025,1.429722547531128,2.71156,2.802791201002504,2.580905,2.626520600501252,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.05,-0.06818,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.4274,0.9321,-22.2419,-6.97309884514643,0.7870781404526453,Pathogenic,0.9912,pathogenic,-4.182,available,https://doi.org/10.1101/2022.10.22.513328 +M169E,NP_000537:p.Met169Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.24898,0.7240781188011169,1.43707,1.9890272830662763,1.343025,1.6190036415331381,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,-0.09502,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.4176,0.9321,-22.2419,-6.97309884514643,0.5070434088837751,Uncertain,0.9216,pathogenic,-4.024,available,https://doi.org/10.1101/2022.10.22.513328 +M169F,NP_000537:p.Met169Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.60868,0.9404338598251344,2.74558,0.9335342607877702,2.67713,1.7711071303938852,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.05,-0.00382,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.17,T,-0.321,0.9321,-22.2419,-5.09771817264625,0.1152076591401682,Benign,0.688,pathogenic,-3.638,available,https://doi.org/10.1101/2022.10.22.513328 +M169G,NP_000537:p.Met169Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.28194,0.8533550500869751,1.88707,2.7509660443005712,2.084505,2.5164530221502854,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.05,0.10542,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.3968,0.9321,-22.2419,-7.21542309947019,0.6674679097821479,Uncertain,0.9474,pathogenic,-4.16,available,https://doi.org/10.1101/2022.10.22.513328 +M169H,NP_000537:p.Met169His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.6754,0.7411607503890991,1.52789,1.468469892430554,2.601645,2.571934946215277,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.05,-0.01432,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.3742,0.9321,-22.2419,-5.99304405598151,0.6189120159262327,Uncertain,0.9264,pathogenic,-4.077,available,https://doi.org/10.1101/2022.10.22.513328 +M169I,NP_000537:p.Met169Ile,"hg19,17:g.7578423C>A, hg19,17:g.7578423C>T, hg19,17:g.7675105C>T, hg38,17:g.7675105C>A, hg38,17:g.7675105C>T",,,0.597,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",919322,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.44136,0.5852053761482239,-0.12245,1.0920807672941402,0.15945499999999999,0.7667203836470701,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,-0.06732,0.00802,Neutral,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.17,T,-0.1501,0.9321,-5.9542,-1.84578901987421,7.352173913828294e-05,Benign,0.6481,pathogenic,-3.026,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M169K,NP_000537:p.Met169Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.67638,0.0109925270080566,0.78605,1.4516797489865323,0.731215,1.0640298744932661,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.03588,0.01101,Neutral,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.17,T,-0.3785,0.9321,-22.2419,-5.98260746006438,0.2028107539774008,Benign,0.7249,pathogenic,-3.796,available,https://doi.org/10.1101/2022.10.22.513328 +M169L,NP_000537:p.Met169Leu,"hg19,17:g.7578425T>A, hg38,17:g.7675107T>A",,,0.562,"cBioPortal,ClinVar,saturation_mutlist",2886753,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.34033,0.5144744515419006,0.07959,0.7817992326828538,0.20996,0.5610646163414269,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,-0.0247,0.13226,Neutral,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.17,T,-0.1273,0.9321,-7.9541,-2.49460539608368,0.0012754521597114,Benign,0.3431,ambiguous,-3.216,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M169N,NP_000537:p.Met169Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.43705,0.8094016313552856,1.58776,1.9878592907184656,2.012405,2.212454645359233,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.05,0.01742,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.369,0.9321,-22.2419,-6.97309884514643,0.5247185419481961,Uncertain,0.9339,pathogenic,-3.89,available,https://doi.org/10.1101/2022.10.22.513328 +M169P,NP_000537:p.Met169Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.47474,1.7884163856506348,6.63401,6.673980165768234,4.554375,4.574360082884117,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.05,0.09628,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.4869,0.9321,-22.2419,-7.21542309947019,0.6361762605733088,Uncertain,0.9904,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328 +M169Q,NP_000537:p.Met169Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.76449,-0.0890313386917114,0.88435,1.4990743023154924,0.8244199999999999,1.1317821511577462,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.00424,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.3611,0.9321,-22.2419,-6.97309884514643,0.1593509397416876,Benign,0.6168,pathogenic,-3.694,available,https://doi.org/10.1101/2022.10.22.513328 +M169R,NP_000537:p.Met169Arg,"hg19,17:g.7578424A>C, hg38,17:g.7675106A>C",,,0.740,"ClinVar,saturation_mutlist",568736,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.82856,0.0518872737884521,0.4449,1.0654308063091074,0.63673,0.9469954031545537,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.18682,-0.29031,Neutral,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.17,T,-0.3329,0.9321,-7.9541,-4.27667041598335,0.0005118065385488,Benign,0.6324,pathogenic,-3.413,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M169S,NP_000537:p.Met169Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.64464,0.3706475496292114,0.82007,2.3200862832727003,1.232355,1.98236314163635,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.05,0.1174,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.3473,0.9321,-22.2419,-5.26013122331273,0.2042207786376711,Benign,0.8511,pathogenic,-3.616,available,https://doi.org/10.1101/2022.10.22.513328 +M169T,NP_000537:p.Met169Thr,"hg19,17:g.7578424A>G, hg19,17:g.7675106A>G, hg38,17:g.7675106A>G",,,0.726,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.30714,0.6364971399307251,1.27891,1.81758152233976,1.293025,1.56236076116988,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.08916,-0.0668,Neutral,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.2871,0.9321,-22.2419,-5.6705964229845,0.3075462258504925,Benign,0.7014,pathogenic,-3.497,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M169V,NP_000537:p.Met169Val,"hg19,17:g.7578425T>C, hg38,17:g.7675107T>C",,,0.503,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",844926,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.87621,0.6926476955413818,0.60272,1.216213775092251,0.739465,1.0462118875461255,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,-0.02128,-0.04133,Neutral,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.1537,0.9321,-0.373,-0.50685064374124,9.488448037917104e-08,Benign,0.1036,benign,-2.812,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M169W,NP_000537:p.Met169Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.09735,1.0484572649002075,0.51293,0.799398872215529,2.3051399999999997,2.4483744361077644,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.05,-0.0548,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.17,T,-0.3838,0.9321,-22.2419,-5.99304405598151,0.5508821553828736,Uncertain,0.9349,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328 +M169Y,NP_000537:p.Met169Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.1487,1.115742325782776,2.31361,1.162898216347259,3.231155,2.655799108173629,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.05,-0.01866,,,,,,,,20.9,,True,20.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.17,T,-0.3633,0.9321,-22.2419,-5.11695802785901,0.2960674681770635,Benign,0.9203,pathogenic,-3.774,available,https://doi.org/10.1101/2022.10.22.513328 +T170A,NP_000537:p.Thr170Ala,"hg19,17:g.7578422T>C, hg38,17:g.7675104T>C",,,0.518,"COSMIC,ClinVar,saturation_mutlist",135949,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.94309,0.6653912663459778,-0.20374,0.3377700345637952,-0.573415,-0.3026599827181024,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.0305,0.01844,Neutral,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.1312,0.9789,-2.3395,-1.63523202592168,2.7914554906054854e-08,Benign,0.2803,benign,-3.019,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T170C,NP_000537:p.Thr170Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.49179,0.3750761747360229,0.57585,0.93421443603929,-0.45797,-0.278787781980355,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.031,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.2686,0.9789,-22.2419,-3.58873454267009,0.3745127351272354,Uncertain,0.8137,pathogenic,-3.82,available,https://doi.org/10.1101/2022.10.22.513328 +T170D,NP_000537:p.Thr170Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.56627,1.2203783988952637,-0.13912,0.2573531981520044,-0.35269500000000004,-0.15445840092399782,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.07,-0.16158,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,93.17,T,-0.3483,0.9789,-22.2419,-4.93597296061548,0.6335371677960596,Uncertain,0.9157,pathogenic,-3.966,available,https://doi.org/10.1101/2022.10.22.513328 +T170E,NP_000537:p.Thr170Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.21052,1.1080070734024048,-0.41327,0.0412975741238513,-0.811895,-0.5846112129380744,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.07,-0.3281,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.3236,0.9789,-22.2419,-4.23336195320994,0.0954653957150425,Benign,0.8414,pathogenic,-3.718,available,https://doi.org/10.1101/2022.10.22.513328 +T170F,NP_000537:p.Thr170Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.44574,0.5206465721130371,-1.06803,-0.3350012816614556,-1.256885,-0.8903706408307278,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.06334,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.34,0.9789,-22.2419,-5.19110274730106,0.3158368324363094,Benign,0.9103,pathogenic,-4.088,available,https://doi.org/10.1101/2022.10.22.513328 +T170G,NP_000537:p.Thr170Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.28779,0.7155957221984863,0.92143,0.9359773470200125,0.31682,0.32409367351000623,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.0239,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.2384,0.9789,-8.9541,-3.9733966694728,0.0079987080558211,Benign,0.5247,ambiguous,-3.525,available,https://doi.org/10.1101/2022.10.22.513328 +T170H,NP_000537:p.Thr170His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.36183,0.3898261189460754,-0.72619,-0.2448232434599317,-1.04401,-0.8033266217299659,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.03764,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.3203,0.9789,-22.2419,-4.46118124137844,0.0588190390235162,Benign,0.8188,pathogenic,-3.79,available,https://doi.org/10.1101/2022.10.22.513328 +T170I,NP_000537:p.Thr170Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.18349,0.7487364411354065,0.20578,-0.1422306326586636,-0.488855,-0.6628603163293317,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.05676,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.2586,0.9789,-22.2419,-5.08873994947393,0.5547452012373151,Uncertain,0.8872,pathogenic,-3.901,available,https://doi.org/10.1101/2022.10.22.513328 +T170K,NP_000537:p.Thr170Lys,"hg19,17:g.7578421G>T",,,0.827,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.17096,0.4142259955406189,-0.67993,-0.0076333592073435,-0.9254450000000001,-0.5892966796036717,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.04548,-0.01642,Neutral,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.248,0.9789,-8.9541,-4.11631657448966,0.0034044676136095,Benign,0.7513,pathogenic,-3.782,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T170L,NP_000537:p.Thr170Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.30349,0.5959303975105286,-1.23639,-0.5161929398747978,-1.26994,-0.9098414699373989,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.03268,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.3106,0.9789,-22.2419,-4.93825803368832,0.1181013369654958,Benign,0.4268,ambiguous,-3.767,available,https://doi.org/10.1101/2022.10.22.513328 +T170M,NP_000537:p.Thr170Met,"hg19,17:g.7578421G>A, hg38,17:g.7675103G>A",3.186336987e-05,4.7747511161e-05,0.868,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",184014,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.43944,0.6396539211273193,-1.04048,-0.0801687960908276,-1.23996,-0.7598043980454138,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.04562,0.03224,Neutral,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.1995,0.9789,-6.9542,-2.97207536319492,0.0028438986608866,Benign,0.2516,benign,-3.499,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T170N,NP_000537:p.Thr170Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.49244,0.4927351474761963,-0.6881,0.2912464303931927,-1.09027,-0.6005967848034036,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.03766,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,93.17,T,-0.2884,0.9789,-22.2419,-4.3449282684324,0.0743072165059813,Benign,0.5438,ambiguous,-3.47,available,https://doi.org/10.1101/2022.10.22.513328 +T170P,NP_000537:p.Thr170Pro,"hg38,17:g.7675104T>G",,,0.808,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.38791,1.0959479808807373,3.25068,1.2842951335526245,0.931385,-0.05180743322368775,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.07,-0.05668,-0.11168,Neutral,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,93.17,T,-0.397,0.9789,-22.2419,-5.92405679685997,0.2455088462568569,Benign,0.6747,pathogenic,-3.997,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T170Q,NP_000537:p.Thr170Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.43916,0.7278556227684021,-0.72823,0.2114490118735956,-1.083695,-0.6138554940632022,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.1232,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.2978,0.9789,-22.2419,-3.93212575064101,0.0435043919668773,Benign,0.6245,pathogenic,-3.663,available,https://doi.org/10.1101/2022.10.22.513328 +T170R,NP_000537:p.Thr170Arg,"hg19,17:g.7578421G>C, hg38,17:g.7675103G>C",,,0.867,"COSMIC,ClinVar,saturation_mutlist",490174,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.92278,0.3149076700210571,-1.22347,-0.2222028396320335,-1.073125,-0.5724914198160168,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.1944,-0.12295,Neutral,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.3187,0.9789,-22.2419,-4.25530568069192,0.0118087553459044,Benign,0.6801,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T170S,NP_000537:p.Thr170Ser,"hg19,17:g.7578422T>A, hg38,17:g.7675104T>A",,,0.629,"COSMIC,ClinVar,saturation_mutlist",3460324,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.4026,0.4122123718261719,-0.0568,0.2969283752206125,-0.7297,-0.5528358123896938,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.0314,-0.18039,Neutral,,Uncertain,,,Uncertain,51.7,,True,51.7,,neutral,,,DOWN,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.1104,0.9789,-5.3692,-2.03573026158437,2.5391025555328576e-05,Benign,0.4327,ambiguous,-3.127,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T170V,NP_000537:p.Thr170Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.79509,0.732711911201477,-0.23673,0.0420393733177953,-0.51591,-0.37652531334110234,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.0623,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.2462,0.9789,-22.2419,-5.15187958193741,0.4969348465075562,Uncertain,0.6648,pathogenic,-3.835,available,https://doi.org/10.1101/2022.10.22.513328 +T170W,NP_000537:p.Thr170Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.52028,0.3991996645927429,-1.27925,-0.7477381141074313,-1.399765,-1.1340090570537158,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.04696,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.3329,0.9789,-22.2419,-5.19110274730106,0.7188222046554987,Pathogenic,0.9631,pathogenic,-4.368,available,https://doi.org/10.1101/2022.10.22.513328 +T170Y,NP_000537:p.Thr170Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.38153,0.3302846550941467,-1.58503,-0.2689181217421349,-1.48328,-0.8252240608710675,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.05418,,Uncertain,,Uncertain,,,Uncertain,51.7,,True,51.7,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,93.17,T,-0.3414,0.9789,-22.2419,-4.79566905823871,0.4748619590827574,Uncertain,0.925,pathogenic,-4.052,available,https://doi.org/10.1101/2022.10.22.513328 +E171A,NP_000537:p.Glu171Ala,"hg38,17:g.7675100T>G",,,0.896,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.96443,0.6167716383934021,1.06463,0.6579636353732299,1.01453,0.8111968176866149,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,2.50404,0.31885,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,94.24,S,-0.272,0.5293,-22.2419,-6.20129813780346,0.8373121047413129,Pathogenic,0.8731,pathogenic,-4.196,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E171C,NP_000537:p.Glu171Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.35961,0.1592999696731567,0.73333,1.095453057999895,1.04647,1.2275315289999473,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,1.83924,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,94.24,S,-0.3413,0.5293,-22.2419,-6.20129813780346,0.8483112769064071,Pathogenic,0.9944,pathogenic,-4.558,available,https://doi.org/10.1101/2022.10.22.513328 +E171D,NP_000537:p.Glu171Asp,"hg19,17:g.7578417C>A, hg19,17:g.7578417C>G, hg38,17:g.7675099C>A, hg38,17:g.7675099C>G",,,0.597,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2446885,Pathogenic,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.06342,1.12949538230896,0.99694,0.8997858285854795,0.46676,0.41818291429273974,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.083,-0.9934,-0.66302,Neutral,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,94.24,S,-0.1402,0.5293,-3.1468,-1.85058558362392,0.0002006478202313,Benign,0.3892,ambiguous,-3.196,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E171F,NP_000537:p.Glu171Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.61166,0.5377534627914429,-0.29694,-0.5862554638403344,0.15736,0.012702268079832768,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,1.97274,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.24,S,-0.3189,0.5293,-22.2419,-6.11269247840749,0.8645037634523982,Pathogenic,0.9972,pathogenic,-4.672,available,https://doi.org/10.1101/2022.10.22.513328 +E171G,NP_000537:p.Glu171Gly,"hg19,17:g.7578418T>C, hg38,17:g.7675100T>C",,,0.917,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1745525,Pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.95304,0.7983875870704651,1.56327,1.800733895640974,1.758155,1.876886947820487,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,2.57232,0.13283,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,94.24,S,-0.2977,0.5293,-22.2419,-6.9789271754094,0.8596835406908515,Pathogenic,0.9178,pathogenic,-4.153,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E171H,NP_000537:p.Glu171His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.61705,0.4917449951171875,0.44388,0.0092726988350938,1.030465,0.8131613494175469,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,1.70654,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.24,S,-0.3102,0.5293,-22.2419,-5.57283775201868,0.3275589846958389,Uncertain,0.9814,pathogenic,-4.166,available,https://doi.org/10.1101/2022.10.22.513328 +E171I,NP_000537:p.Glu171Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.74821,0.9893315434455872,0.22789,-0.5162264069383254,0.48805000000000004,0.1159917965308373,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,1.15782,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.24,S,-0.3243,0.5293,-22.2419,-5.68046272627712,0.6877757892867329,Pathogenic,0.9846,pathogenic,-4.461,available,https://doi.org/10.1101/2022.10.22.513328 +E171K,NP_000537:p.Glu171Lys,"hg19,17:g.7578419C>T, hg19,17:g.7675101C>T, hg38,17:g.7675101C>T",,,0.873,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141566,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.51121,0.5752992033958435,0.07313,0.5311383049818005,0.7921699999999999,1.0211741524909002,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,2.31078,0.92485,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.24,S,-0.294,0.5293,-22.2419,-5.44074972072355,0.3133525086165007,Benign,0.926,pathogenic,-4.017,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E171L,NP_000537:p.Glu171Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.45592,0.4139362573623657,-0.16769,-0.5319404470705819,0.144115,-0.03801022353529093,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,1.53092,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.24,S,-0.2586,0.5293,-8.9541,-4.34211159717172,0.038424368418548,Benign,0.976,pathogenic,-4.122,available,https://doi.org/10.1101/2022.10.22.513328 +E171M,NP_000537:p.Glu171Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.16571,0.2860867977142334,0.39932,0.0655243459071647,0.282515,0.11561717295358234,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,2.3917,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.24,S,-0.2753,0.5293,-22.2419,-5.25379652477179,0.8166192332781916,Pathogenic,0.9731,pathogenic,-4.401,available,https://doi.org/10.1101/2022.10.22.513328 +E171N,NP_000537:p.Glu171Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.58514,0.7812123894691467,0.72925,0.712831391624156,1.157195,1.1489856958120779,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,2.10708,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,94.24,S,-0.2982,0.5293,-22.2419,-3.51262689647183,0.4683069683176472,Uncertain,0.9208,pathogenic,-4.095,available,https://doi.org/10.1101/2022.10.22.513328 +E171P,NP_000537:p.Glu171Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.03786,2.350998640060425,7.27993,3.1618825546491034,4.158895,2.0998712773245516,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.083,2.45112,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,94.24,S,-0.4289,0.5293,-22.2419,-6.9789271754094,0.8667667634642175,Pathogenic,0.9985,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328 +E171Q,NP_000537:p.Glu171Gln,"hg38,17:g.7675101C>G",,,0.849,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.08925,0.0616737604141235,0.3949,0.3673088771251931,0.152825,0.13902943856259656,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,2.14742,0.60513,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.24,S,-0.2445,0.5293,-22.2419,-3.43028631755335,0.4445999987901167,Uncertain,0.8251,pathogenic,-3.892,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E171R,NP_000537:p.Glu171Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.02653,0.718772292137146,0.49626,0.1693003101617596,1.261395,1.09791515508088,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.083,3.27656,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.24,S,-0.3545,0.5293,-22.2419,-6.16910998387994,0.6827825182287437,Pathogenic,0.9552,pathogenic,-4.291,available,https://doi.org/10.1101/2022.10.22.513328 +E171S,NP_000537:p.Glu171Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.59924,0.9784796237945556,1.60442,1.1554505638494696,1.60183,1.3773452819247347,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,2.50476,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,94.24,S,-0.2854,0.5293,-22.2419,-5.84841661659109,0.3858493506300259,Uncertain,0.8916,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328 +E171T,NP_000537:p.Glu171Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.81429,0.9167386889457704,0.82279,0.5971940028700825,1.31854,1.2057420014350413,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,1.98272,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,94.24,S,-0.3013,0.5293,-22.2419,-5.98009043541364,0.3577504317662678,Uncertain,0.9385,pathogenic,-4.148,available,https://doi.org/10.1101/2022.10.22.513328 +E171V,NP_000537:p.Glu171Val,"hg38,17:g.7675099_7675100delinsGA, hg38,17:g.7675100T>A",,,0.922,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.12863,0.9393517971038818,0.09456,-0.2853473074434626,0.611595,0.4216413462782687,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,1.45862,0.06629,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,94.24,S,-0.2852,0.5293,-22.2419,-4.31924205743371,0.1830653811838435,Benign,0.9389,pathogenic,-4.167,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E171W,NP_000537:p.Glu171Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.56302,0.8723965287208557,-0.56565,-0.9650142213694084,-0.0013150000000000106,-0.20099711068470422,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,3.10162,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.24,S,-0.329,0.5293,-22.2419,-6.11269247840749,0.838151485614168,Pathogenic,0.9985,pathogenic,-4.803,available,https://doi.org/10.1101/2022.10.22.513328 +E171Y,NP_000537:p.Glu171Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.6973,0.6159064173698425,-0.41293,-0.4127799173418178,0.142185,0.14226004132909112,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.083,2.41794,,Uncertain,,Uncertain,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,94.24,S,-0.3198,0.5293,-22.2419,-5.7872977344495,0.682059763144565,Pathogenic,0.9934,pathogenic,-4.49,available,https://doi.org/10.1101/2022.10.22.513328 +V172A,NP_000537:p.Val172Ala,"hg19,17:g.7578415A>G, hg38,17:g.7675097A>G",,,0.850,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528245,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.46214,1.159624695777893,0.79116,1.775630349690006,1.12665,1.618885174845003,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.171,-0.00052,0.12041,Neutral,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.19,-,-0.2594,0.2583,-8.9541,-4.14941940549315,0.0108297785586636,Benign,0.7232,pathogenic,-3.474,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V172C,NP_000537:p.Val172Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.39183,0.9233933687210084,0.88401,1.8293483505583663,1.1379199999999998,1.6105891752791832,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.171,-0.37606,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.19,-,-0.3551,0.2583,-22.2419,-6.0281969995146,0.6795332426518242,Pathogenic,0.9718,pathogenic,-4.153,available,https://doi.org/10.1101/2022.10.22.513328 +V172D,NP_000537:p.Val172Asp,"hg19,17:g.7578415A>T, hg19,17:g.7675097A>T, hg38,17:g.7675097A>T",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",836761,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.68208,1.9132136106491089,2.88707,2.078070435544225,2.2845750000000002,1.8800752177721125,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.171,-0.52116,0.51658,Neutral,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.19,-,-0.4938,0.2583,-22.2419,-6.47107433973364,0.8192479048304208,Pathogenic,0.9749,pathogenic,-4.461,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V172E,NP_000537:p.Val172Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.36243,2.057119131088257,3.40884,1.705644807388504,2.385635,1.534037403694252,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,False,0.171,-0.65056,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.19,-,-0.4511,0.2583,-22.2419,-6.47107433973364,0.7258366335076318,Pathogenic,0.9553,pathogenic,-4.31,available,https://doi.org/10.1101/2022.10.22.513328 +V172F,NP_000537:p.Val172Phe,"hg19,17:g.7578416C>A, hg19,17:g.7675098C>A, hg38,17:g.7675098C>A",,,0.917,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428909,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.58964,1.588165044784546,6.3881,0.99829232088184,4.98887,2.2939661604409203,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.171,-0.2042,0.33193,Neutral,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.19,-,-0.4044,0.2583,-22.2419,-6.57026057590032,0.8285234603317373,Pathogenic,0.9499,pathogenic,-4.239,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V172G,NP_000537:p.Val172Gly,"hg19,17:g.7578415A>C, hg19,17:g.7675097A>C, hg38,17:g.7675097A>C",,,0.953,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428883,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.29448,2.1753480434417725,2.62585,3.1354668106094388,2.460165,2.714973405304719,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.171,-0.7659,0.08548,Neutral,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.19,-,-0.453,0.2583,-22.2419,-7.50111738309872,0.7032589524280239,Pathogenic,0.8569,pathogenic,-4.31,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V172H,NP_000537:p.Val172His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.18437,1.3698246479034424,4.50714,1.3694428460262331,5.8457550000000005,4.276906423013116,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.171,-0.9242,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.19,-,-0.4968,0.2583,-22.2419,-6.63881417978547,0.651782729806701,Uncertain,0.9935,pathogenic,-4.299,available,https://doi.org/10.1101/2022.10.22.513328 +V172I,NP_000537:p.Val172Ile,"hg19,17:g.7578416C>T, hg38,17:g.7675098C>T",,,0.645,"COSMIC,ClinVar,saturation_mutlist",825481,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.74887,0.5783871412277222,1.07551,-0.5213054726610072,0.16331999999999997,-0.6350877363305036,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.171,0.03286,-0.24186,Neutral,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.19,-,-0.175,0.2583,-5.0473,-1.78606063993282,0.0012689668146295,Benign,0.1538,benign,-3.458,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V172K,NP_000537:p.Val172Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.19944,1.6141626834869385,2.14286,1.8011806338055227,4.67115,4.500310316902762,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.171,-0.74258,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.19,-,-0.4901,0.2583,-22.2419,-7.50111738309872,0.8583125612510184,Pathogenic,0.9808,pathogenic,-4.493,available,https://doi.org/10.1101/2022.10.22.513328 +V172L,NP_000537:p.Val172Leu,"hg38,17:g.7675098C>G",,,0.815,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.90297,1.337153673171997,1.52517,0.1290495919373668,1.21407,0.5160097959686835,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.171,-0.27942,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.19,-,-0.26,0.2583,-8.9541,-2.31769997335832,0.1190957505289,Benign,0.9284,pathogenic,-3.71,available,https://doi.org/10.1101/2022.10.22.513328 +V172M,NP_000537:p.Val172Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.86031,1.4947062730789185,2.83435,1.105915601946192,1.8473300000000001,0.9831128009730961,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.171,-0.5559,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.19,-,-0.3369,0.2583,-22.2419,-4.51094561034991,0.784579648811563,Pathogenic,0.8346,pathogenic,-4.098,available,https://doi.org/10.1101/2022.10.22.513328 +V172N,NP_000537:p.Val172Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.75234,1.838402271270752,2.34082,1.514662260283532,2.04658,1.6335011301417661,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.171,-0.3798,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.19,-,-0.4817,0.2583,-22.2419,-5.92344084955504,0.2964712037998355,Benign,0.9103,pathogenic,-4.048,available,https://doi.org/10.1101/2022.10.22.513328 +V172P,NP_000537:p.Val172Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14271,1.044391632080078,2.42823,3.256542141490557,1.2854700000000001,1.6996260707452786,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.171,-0.66628,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.19,-,-0.5316,0.2583,-22.2419,-4.76107805621625,0.1236054865349592,Benign,0.8202,pathogenic,-3.889,available,https://doi.org/10.1101/2022.10.22.513328 +V172Q,NP_000537:p.Val172Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.56264,1.4921241998672483,1.9102,1.7518866321730802,1.7364199999999999,1.65726331608654,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.171,-0.93468,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.19,-,-0.4617,0.2583,-22.2419,-5.54356968062171,0.7047432573276154,Pathogenic,0.9691,pathogenic,-4.258,available,https://doi.org/10.1101/2022.10.22.513328 +V172R,NP_000537:p.Val172Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.91881,1.5871286392211914,2.66939,1.420256573232559,4.2941,3.6695332866162795,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.171,-0.95196,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.19,-,-0.5111,0.2583,-22.2419,-7.50111738309872,0.8324630560743803,Pathogenic,0.9689,pathogenic,-4.258,available,https://doi.org/10.1101/2022.10.22.513328 +V172S,NP_000537:p.Val172Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.34284,1.4238288402557373,1.26599,2.2299341613776007,1.8044149999999999,2.2863870806888,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,False,0.171,-0.18402,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.19,-,-0.4309,0.2583,-22.2419,-6.11716716831782,0.5199876439087296,Uncertain,0.8663,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +V172T,NP_000537:p.Val172Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.10947,1.0849714279174805,1.88673,1.1800878432312063,1.9981,1.644778921615603,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.171,-0.57232,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.19,-,-0.2784,0.2583,-8.9541,-5.09449455334904,0.0165052159307684,Benign,0.6829,pathogenic,-3.598,available,https://doi.org/10.1101/2022.10.22.513328 +V172W,NP_000537:p.Val172Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.69212,1.783869981765747,13.21463,0.8536545666351827,12.953375,6.772887283317591,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.171,0.01926,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.19,-,-0.4449,0.2583,-22.2419,-6.99711620516997,0.846602792519322,Pathogenic,0.9974,pathogenic,-4.573,available,https://doi.org/10.1101/2022.10.22.513328 +V172Y,NP_000537:p.Val172Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.40928,1.6462633609771729,7.40408,1.3151628937115205,9.906680000000001,6.86222144685576,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.171,-0.0482,,,,,,,,1.4,,True,1.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.19,-,-0.4478,0.2583,-22.2419,-6.99711620516997,0.838955915607335,Pathogenic,0.9897,pathogenic,-4.468,available,https://doi.org/10.1101/2022.10.22.513328 +V173A,NP_000537:p.Val173Ala,"hg19,17:g.7578412A>G, hg19,17:g.7675094A>G, hg38,17:g.7675094A>G",,,0.758,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376017,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,2.75292,1.4274859428405762,2.50646,2.673512174891853,2.62969,2.7132160874459266,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.223,-0.0014,0.00022,Neutral,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.58,-,-0.3471,0.042,-22.2419,-7.45707742763203,0.6276495518844947,Uncertain,0.9926,pathogenic,-3.983,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173C,NP_000537:p.Val173Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.13585,1.1050071716308594,2.5534,2.5279634325655462,1.844625,1.8319067162827731,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.223,-0.0014,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.58,-,-0.375,0.042,-22.2419,-7.92827937545306,0.8599035716700802,Pathogenic,0.9952,pathogenic,-4.433,available,https://doi.org/10.1101/2022.10.22.513328 +V173D,NP_000537:p.Val173Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.24156,1.8325178623199463,4.4381,4.157871956715085,3.83983,3.699715978357543,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.223,0.08636,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.58,-,-0.5137,0.042,-22.2419,-8.2032647249248,0.8560824997304848,Pathogenic,0.9997,pathogenic,-4.652,available,https://doi.org/10.1101/2022.10.22.513328 +V173E,NP_000537:p.Val173Glu,"hg19,17:g.7578412A>T, hg38,17:g.7675094A>T",,,0.749,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376669,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.36186,2.209164619445801,5.58231,4.057318047496484,4.972085,4.209589023748242,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.223,0.1725,0.16016,Neutral,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.58,-,-0.471,0.042,-22.2419,-8.2032647249248,0.8706375538640991,Pathogenic,0.9987,pathogenic,-4.526,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173F,NP_000537:p.Val173Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,11.18883,1.9834932088851929,5.14286,2.8937220288043064,8.165845,7.041276014402153,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.223,0.0361,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.58,-,-0.4243,0.042,-22.2419,-8.2032647249248,0.8686032996129327,Pathogenic,0.9982,pathogenic,-4.486,available,https://doi.org/10.1101/2022.10.22.513328 +V173G,NP_000537:p.Val173Gly,"hg19,17:g.7578412A>C, hg19,17:g.7675094A>C, hg38,17:g.7675094A>C",,,0.769,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376016,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,4.09452,2.359656572341919,4.93095,4.771492035979136,4.512735,4.433006017989568,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.223,-0.05098,-0.02237,Neutral,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.58,-,-0.4729,0.042,-22.2419,-8.2032647249248,0.8666219235926084,Pathogenic,0.9863,pathogenic,-4.476,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173H,NP_000537:p.Val173His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.77323,2.2218191623687744,7.23776,3.5302326542521243,9.005495,7.151731327126062,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.223,0.00154,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.58,-,-0.5167,0.042,-22.2419,-8.2032647249248,0.8652570263269959,Pathogenic,0.9998,pathogenic,-4.605,available,https://doi.org/10.1101/2022.10.22.513328 +V173I,NP_000537:p.Val173Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.32672,0.6425046920776367,0.90442,0.1947968636173253,1.61557,1.2607584318086626,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.223,0.02598,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.58,-,-0.2827,0.042,-22.2419,-4.69066437486283,0.0797206325882215,Benign,0.6823,pathogenic,-3.558,available,https://doi.org/10.1101/2022.10.22.513328 +V173K,NP_000537:p.Val173Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.55452,2.374492645263672,8.71939,5.188153868823992,9.136955,7.371336934411996,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.223,-0.21528,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.58,-,-0.51,0.042,-22.2419,-8.2032647249248,0.8660616517158137,Pathogenic,0.9991,pathogenic,-4.636,available,https://doi.org/10.1101/2022.10.22.513328 +V173L,NP_000537:p.Val173Leu,"hg19,17:g.7578413C>A, hg19,17:g.7578413C>G, hg19,17:g.7675095C>A, hg19,17:g.7675095C>G, hg38,17:g.7675095C>A, hg38,17:g.7675095C>G",,,0.880,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2185665, 376668","Conflicting classifications of pathogenicity, Pathogenic/Likely pathogenic","1, 2","Oncogenic, Oncogenic","1, 1",Tier III - Unknown,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.74998,0.9332422018051147,3.67687,0.9235206477933956,2.713425,1.3367503238966978,Uncertain,Neutral,Neutral,Uncertain,Neutral,False,0.223,-0.00278,-0.0136,Neutral,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.58,-,-0.2799,0.042,-8.9541,-4.92238514285954,0.18337153375386,Benign,0.9942,pathogenic,-3.778,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173M,NP_000537:p.Val173Met,"hg19,17:g.7578413C>T, hg19,17:g.7675095C>T, hg38,17:g.7675095C>T",,,0.892,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",233951,Pathogenic,3,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.38189,1.7663133144378662,3.85102,2.053113669263656,3.116455,2.217501834631828,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.223,-0.03098,0.02721,Neutral,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.58,-,-0.289,0.042,-8.9541,-4.92238514285954,0.8355857013153355,Pathogenic,0.9974,pathogenic,-4.18,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173N,NP_000537:p.Val173Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.32502,2.185575246810913,3.82211,2.79989610836174,3.573565,3.06245805418087,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.223,-0.00044,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.58,-,-0.5016,0.042,-22.2419,-8.2032647249248,0.8698594361961508,Pathogenic,0.9992,pathogenic,-4.558,available,https://doi.org/10.1101/2022.10.22.513328 +V173P,NP_000537:p.Val173Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.06341,1.5378131866455078,3.47517,5.724199406143133,2.26929,3.3938047030715666,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,False,0.223,0.00984,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.58,-,-0.5515,0.042,-22.2419,-8.2032647249248,0.8706754345595297,Pathogenic,0.9825,pathogenic,-4.568,available,https://doi.org/10.1101/2022.10.22.513328 +V173Q,NP_000537:p.Val173Gln,"hg19,17:g.7578412_7578413delinsTG",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.47539,2.2366597652435303,4.3102,3.106863554749073,3.892795,3.2911267773745365,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.223,-0.0054,-0.11636,Neutral,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.58,-,-0.4816,0.042,-22.2419,-8.2032647249248,0.8704965255436059,Pathogenic,0.9983,pathogenic,-4.513,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173R,NP_000537:p.Val173Arg,"hg19,17:g.7578412_7578413delinsCT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.29356,2.5724518299102783,6.60578,4.122330224256029,9.94967,8.707945112128014,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.223,-0.11784,-0.05018,Neutral,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.58,-,-0.531,0.042,-22.2419,-8.2032647249248,0.8679917307216993,Pathogenic,0.9955,pathogenic,-4.574,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173S,NP_000537:p.Val173Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.88423,2.2546982765197754,3.61633,3.5803979195140565,3.25028,3.232313959757028,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.223,-0.0009,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.58,-,-0.4508,0.042,-22.2419,-7.92827937545306,0.8691313114589929,Pathogenic,0.9936,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +V173T,NP_000537:p.Val173Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.71588,1.9604490995407104,2.50034,2.1653934195043125,2.10811,1.9406367097521562,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.223,-0.0008,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.58,-,-0.3662,0.042,-22.2419,-7.92827937545306,0.8707680835818348,Pathogenic,0.9878,pathogenic,-4.237,available,https://doi.org/10.1101/2022.10.22.513328 +V173W,NP_000537:p.Val173Trp,"hg38,17:g.7675094_7675095delinsCA",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,20.12658,2.185418128967285,10.17959,4.1745705110102165,15.153085,12.150575255505109,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.223,-0.01732,-0.01711,Neutral,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.58,-,-0.4648,0.042,-22.2419,-8.2032647249248,0.8683166845262927,Pathogenic,0.9999,pathogenic,-4.706,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V173Y,NP_000537:p.Val173Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,11.27387,2.229098558425904,5.15748,3.841424393558053,8.215675000000001,7.557647196779027,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.223,-0.02768,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.58,-,-0.4677,0.042,-22.2419,-8.2032647249248,0.8619052369021458,Pathogenic,0.9996,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328 +R174A,NP_000537:p.Arg174Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.07744,2.131187677383423,0.02483,2.0059167622383907,-0.026304999999999995,0.9642383811191954,Neutral,Uncertain,Destabilizing,Neutral,Neutral,False,0.062,0.25692,,,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.3081,1.1062,-22.2419,-4.72992187798467,0.3665833124970366,Uncertain,0.9391,pathogenic,-4.063,available,https://doi.org/10.1101/2022.10.22.513328 +R174C,NP_000537:p.Arg174Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.96341,1.959889531135559,0.22993,2.400312788968094,-0.36674,0.7184513944840469,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.062,0.25926,,,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.317,1.1062,-22.2419,-5.48056831453056,0.1838537252419541,Benign,0.5178,ambiguous,-3.971,available,https://doi.org/10.1101/2022.10.22.513328 +R174D,NP_000537:p.Arg174Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42449,3.3072550296783447,2.15136,2.7560426716677715,1.787925,2.0902663358338858,Uncertain,Uncertain,Destabilizing,Neutral,Uncertain,False,0.062,0.57036,,,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.3991,1.1062,-22.2419,-5.13791349909677,0.6032543399281365,Uncertain,0.9914,pathogenic,-4.303,available,https://doi.org/10.1101/2022.10.22.513328 +R174E,NP_000537:p.Arg174Glu,"hg19,17:g.7578409_7578410delinsTC",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14001,3.1348705291748047,1.13844,2.349501734079716,0.6392249999999999,1.2447558670398582,Neutral,Uncertain,Destabilizing,Neutral,Neutral,False,0.062,0.58976,-0.11356,Neutral,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.3444,1.1062,-22.2419,-4.63478741191056,0.058597875804278,Benign,0.9157,pathogenic,-3.924,available,https://doi.org/10.1101/2022.10.22.513328 +R174F,NP_000537:p.Arg174Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.10698,1.9137505292892456,-1.50782,0.7847275527408487,-0.8074,0.3388737763704244,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.062,0.42004,,,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.61,-,-0.3403,1.1062,-22.2419,-5.76486560057875,0.512784914601213,Uncertain,0.9662,pathogenic,-4.338,available,https://doi.org/10.1101/2022.10.22.513328 +R174G,NP_000537:p.Arg174Gly,"hg19,17:g.7578410T>C, hg38,17:g.7675092T>C",,,0.724,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",219487,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.33685,2.4373154640197754,1.26973,3.1132503064603627,0.8032900000000001,1.7250501532301814,Neutral,Uncertain,Destabilizing,Neutral,Neutral,False,0.062,0.32688,0.13997,Neutral,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.3435,1.1062,-22.2419,-6.76261649386947,0.4914079234965727,Uncertain,0.8976,pathogenic,-4.201,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174H,NP_000537:p.Arg174His,,,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35132,1.8156492710113523,0.46939,1.6230500455635155,0.410355,0.9871850227817578,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.062,-0.23238,-0.44694,Neutral,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.2778,1.1062,-22.2419,-5.18977860616817,0.0137402385614702,Benign,0.4461,ambiguous,-3.666,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174I,NP_000537:p.Arg174Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.32749,2.004089832305908,-0.39354,0.974133992671224,-0.36051500000000003,0.323321996335612,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.062,0.29348,,,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.2697,1.1062,-8.9541,-4.16514624065316,0.0195735368174557,Benign,0.8266,pathogenic,-3.88,available,https://doi.org/10.1101/2022.10.22.513328 +R174K,NP_000537:p.Arg174Lys,"hg19,17:g.7578409C>T, hg38,17:g.7675091C>T",,,0.381,"COSMIC,ClinVar,saturation_mutlist",423887,Likely benign,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.48056,0.6873674392700195,-0.06054,1.7882797950170175,-0.27055,0.6538598975085088,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.062,0.05452,-0.09235,Neutral,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,94.61,-,-0.0882,1.1062,-0.6596,-0.580394831201181,6.672566297598946e-10,Benign,0.1746,benign,-2.805,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174L,NP_000537:p.Arg174Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.3644,2.134351968765259,-0.5483,0.7408941463416946,-0.95635,-0.31175292682915273,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.062,0.30474,,,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.2284,1.1062,-6.1468,-3.65349349166278,0.0016282937568124,Benign,0.7229,pathogenic,-3.602,available,https://doi.org/10.1101/2022.10.22.513328 +R174M,NP_000537:p.Arg174Met,"hg38,17:g.7675091C>A",,,0.628,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.75247,1.9634407758712769,-0.11429,1.3294340647499197,-0.93338,-0.21151796762504016,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.062,0.36632,0.02474,Neutral,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.2764,1.1062,-22.2419,-5.36599101832737,0.1173513300980949,Benign,0.8398,pathogenic,-3.987,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174N,NP_000537:p.Arg174Asn,"hg19,17:g.7578408_7578409delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.08562,2.29673719406128,1.10102,2.224508025788742,0.5077,1.069444012894371,Neutral,Uncertain,Destabilizing,Neutral,Neutral,False,0.062,0.38574,0.20807,Neutral,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.323,1.1062,-22.2419,-5.17496189296656,0.0157746898877589,Benign,0.9769,pathogenic,-3.785,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174P,NP_000537:p.Arg174Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.35609,3.412139892578125,1.06395,3.937452124224484,1.21002,2.646771062112242,Neutral,Uncertain,Destabilizing,Neutral,Uncertain,False,0.062,0.27952,,,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.4502,1.1062,-22.2419,-6.76261649386947,0.6374389555567551,Uncertain,0.9894,pathogenic,-4.378,available,https://doi.org/10.1101/2022.10.22.513328 +R174Q,NP_000537:p.Arg174Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.02087,2.0366427898406982,-0.72211,1.976800004543772,-0.37149,0.977965002271886,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.062,0.42978,,,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.215,1.1062,-8.9541,-3.1896095242181,0.0012307020225878,Benign,0.3163,benign,-3.462,available,https://doi.org/10.1101/2022.10.22.513328 +R174S,NP_000537:p.Arg174Ser,"hg19,17:g.7578408C>G, hg38,17:g.7675090C>A, hg38,17:g.7675090C>G",,,0.639,"COSMIC,ClinVar,saturation_mutlist",1058186,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.46654,2.107825756072998,0.0602,2.5431576736555925,-0.20317000000000002,1.0383088368277962,Neutral,Uncertain,Destabilizing,Neutral,Neutral,False,0.062,0.35988,0.092,Neutral,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.2408,1.1062,-8.9541,-3.60738461544447,0.022393961740522,Benign,0.9558,pathogenic,-3.76,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174T,NP_000537:p.Arg174Thr,"hg19,17:g.7578409C>G",,,0.633,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.95873,1.9429668188095093,0.56837,2.0244169776662817,-0.19517999999999996,0.5328434888331408,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.062,0.30526,0.09093,Neutral,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.313,1.1062,-22.2419,-4.42681812986421,0.0067137816840347,Benign,0.8583,pathogenic,-3.728,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174V,NP_000537:p.Arg174Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.50648,1.8995553255081177,-0.76769,1.2875840227657902,-0.637085,0.3905520113828951,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.062,0.23826,,,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,94.61,-,-0.2568,1.1062,-8.9541,-5.04406001025876,0.0510996475633867,Benign,0.8273,pathogenic,-3.892,available,https://doi.org/10.1101/2022.10.22.513328 +R174W,NP_000537:p.Arg174Trp,"hg19,17:g.7578410T>A, hg19,17:g.7675092T>A, hg38,17:g.7675092T>A",,,0.634,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",964680,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.26923,2.2268402576446533,0.01803,0.6442757445739141,-0.12560000000000002,0.18752287228695705,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.062,0.15562,-0.21148,Neutral,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.61,-,-0.3258,1.1062,-22.2419,-5.76486560057875,0.7016290767739689,Pathogenic,0.7385,pathogenic,-4.242,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R174Y,NP_000537:p.Arg174Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.08495,1.8739553689956665,-1.56599,0.8753102520513897,-0.82547,0.39518012602569486,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.062,0.91578,,,,,,,,21.9,,True,21.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.61,-,-0.3296,1.1062,-22.2419,-5.38008969887271,0.4425989469620988,Uncertain,0.9223,pathogenic,-4.114,available,https://doi.org/10.1101/2022.10.22.513328 +R175A,NP_000537:p.Arg175Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.15619,0.220544695854187,1.92959,1.4935764382275845,1.5428899999999999,1.3248832191137923,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,0.79916,,,,,0.58686,,,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.4005,0.1023,-22.2419,-6.55462687626449,0.7557877418565699,Pathogenic,0.9957,pathogenic,-4.308,available,https://doi.org/10.1101/2022.10.22.513328 +R175C,NP_000537:p.Arg175Cys,"hg19,17:g.7578407G>A, hg19,17:g.7675089G>A, hg38,17:g.7675089G>A",3.18613394507e-05,1.59182438993e-05,0.833,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",245851,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.92406,-0.2799991369247436,1.32313,2.002168179344339,1.123595,1.4631140896721695,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.025,0.85572,0.03306,Neutral,,,0.52874,-0.38703,Neutral,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.4093,0.1023,-22.2419,-2.9230705029414,3.6822646623389545e-05,Benign,0.9186,pathogenic,-3.643,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R175D,NP_000537:p.Arg175Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.4311,0.6110793352127075,3.57755,2.818284120966019,3.5043249999999997,3.1246920604830093,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.025,0.8309,,,,,0.93034,,,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.4915,0.1023,-22.2419,-7.61120498653563,0.8013447186274274,Pathogenic,0.9996,pathogenic,-4.629,available,https://doi.org/10.1101/2022.10.22.513328 +R175E,NP_000537:p.Arg175Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.64497,0.6947083473205566,4.08095,2.300392346927973,3.8629599999999997,2.9726811734639864,Destabilizing,Uncertain,Neutral,Destabilizing,Uncertain,False,0.025,0.75394,,,,,0.88542,,,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.4368,0.1023,-22.2419,-7.61120498653563,0.5684115075558539,Uncertain,0.9975,pathogenic,-4.567,available,https://doi.org/10.1101/2022.10.22.513328 +R175F,NP_000537:p.Arg175Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,14.91846,0.8459389209747314,2.72585,1.2272864836809312,8.822155,8.072873241840465,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.025,0.8422,,,,,0.59578,,,2.1,,True,2.1,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,96.38,-,-0.4326,0.1023,-22.2419,-6.99788038686524,0.7528685102312314,Pathogenic,0.9995,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328 +R175G,NP_000537:p.Arg175Gly,"hg19,17:g.7578407G>C, hg19,17:g.7675089G>C, hg38,17:g.7675089G>C",,,0.829,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376649,Pathogenic,3,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.92643,0.6754902601242065,4.32721,3.0172484605233127,3.12682,2.4718392302616565,Uncertain,Uncertain,Neutral,Destabilizing,Uncertain,False,0.025,0.78448,-0.05355,Neutral,,,0.48234,-0.07121,Neutral,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.4358,0.1023,-22.2419,-7.87534951410341,0.7317191252905382,Pathogenic,0.9953,pathogenic,-4.462,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R175H,NP_000537:p.Arg175His,"hg19,17:g.7578405_7578406delinsAT, hg19,17:g.7578406C>T, hg19,17:g.7675088C>T, hg38,17:g.7675088C>T",,3.9796876741e-06,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12374,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,10.02063,0.664991021156311,2.95034,1.6727790409459142,6.485485000000001,5.846704520472957,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.025,0.96748,0.1336,Neutral,,,0.83762,-0.37586,Neutral,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.2906,0.1023,-6.6322,-4.07240332268089,0.0026003506839338,Benign,0.9857,pathogenic,-3.658,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R175I,NP_000537:p.Arg175Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.75958,-0.1069555282592773,0.59932,0.5194537619141715,1.1794499999999999,1.1395168809570857,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,0.91664,,,,,0.55274,,,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.4299,0.1023,-22.2419,-7.34706045896784,0.5849863638265376,Uncertain,0.9939,pathogenic,-4.471,available,https://doi.org/10.1101/2022.10.22.513328 +R175K,NP_000537:p.Arg175Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01449,-0.076104462146759,2.25,1.5853761739539631,1.132245,0.7999330869769815,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.025,0.3862,,,,,0.19203,,,2.1,,True,2.1,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,96.38,-,-0.2907,0.1023,-22.2419,-4.72832862028865,0.532865516440628,Uncertain,0.9728,pathogenic,-3.912,available,https://doi.org/10.1101/2022.10.22.513328 +R175L,NP_000537:p.Arg175Leu,"hg19,17:g.7578406C>A, hg19,17:g.7675088C>A, hg38,17:g.7675088C>A",,,0.960,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182963,Likely pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.25423,-0.7564741373062134,1.29354,0.2948672148060632,0.7738849999999999,0.2745486074030316,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,0.89986,-0.05928,Neutral,,,0.52757,0.02349,Neutral,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.4029,0.1023,-22.2419,-7.34706045896784,0.8105074130572403,Pathogenic,0.9907,pathogenic,-4.308,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R175M,NP_000537:p.Arg175Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.26715,0.0876882672309875,0.72449,1.0357434281121685,0.22866999999999998,0.38429671405608423,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,0.83418,,,,,0.48545,,,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.3688,0.1023,-22.2419,-6.69015758080641,0.4882548951975969,Uncertain,0.999,pathogenic,-4.286,available,https://doi.org/10.1101/2022.10.22.513328 +R175N,NP_000537:p.Arg175Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.77414,0.5105124711990356,1.72483,1.831399430072829,1.249485,1.3027697150364146,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,0.88186,,,,,0.60316,,,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.4154,0.1023,-22.2419,-7.61120498653563,0.8135016207819172,Pathogenic,0.9985,pathogenic,-4.43,available,https://doi.org/10.1101/2022.10.22.513328 +R175P,NP_000537:p.Arg175Pro,"hg38,17:g.7675088C>G",,,0.966,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.26498,0.2904236316680908,3.07891,4.356231280182692,1.406965,2.0456256400913464,Uncertain,Uncertain,Neutral,Neutral,Uncertain,False,0.025,0.85922,-0.12737,Neutral,,,0.54287,-0.0296,Neutral,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.4747,0.1023,-8.9541,-7.87534951410341,0.0379669720197514,Benign,0.9906,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R175Q,NP_000537:p.Arg175Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.81915,0.3524464666843414,1.49116,1.6875178068065837,1.6551550000000002,1.7533339034032918,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,0.8598,,,,,0.60259,,,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.3752,0.1023,-22.2419,-7.29394435525091,0.3424605894188586,Uncertain,0.9764,pathogenic,-4.011,available,https://doi.org/10.1101/2022.10.22.513328 +R175S,NP_000537:p.Arg175Ser,"hg19,17:g.7578407G>T, hg38,17:g.7675089G>T",,,0.831,"COSMIC,ClinVar,saturation_mutlist",4189264,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.88645,0.393252283334732,2.81395,2.2527508241328453,2.3502,2.0696004120664226,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.025,0.8499,-0.11792,Neutral,,,0.60054,-0.31076,Neutral,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.401,0.1023,-22.2419,-6.55462687626449,0.532830462460785,Uncertain,0.9988,pathogenic,-4.155,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R175T,NP_000537:p.Arg175Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.33505,0.1902100443840026,1.71871,1.7335742540018575,1.52688,1.5343121270009288,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,0.76542,,,,,0.56669,,,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.4054,0.1023,-22.2419,-6.55462687626449,0.4978131721281743,Uncertain,0.997,pathogenic,-4.212,available,https://doi.org/10.1101/2022.10.22.513328 +R175V,NP_000537:p.Arg175Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.59665,-0.5804344415664673,0.59218,0.5810126009208219,0.594415,0.5888313004604109,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,0.85096,,,,,0.67947,,,2.1,,True,2.1,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.38,-,-0.417,0.1023,-22.2419,-7.34706045896784,0.6659790426552431,Uncertain,0.9898,pathogenic,-4.288,available,https://doi.org/10.1101/2022.10.22.513328 +R175W,NP_000537:p.Arg175Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,15.73656,0.8740712404251099,3.53605,0.9604258688588564,9.636305,8.348492934429428,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.025,0.80986,,,,,0.56038,,,2.1,,True,2.1,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,96.38,-,-0.4182,0.1023,-22.2419,-6.99788038686524,0.7456304957975548,Pathogenic,0.9938,pathogenic,-4.319,available,https://doi.org/10.1101/2022.10.22.513328 +R175Y,NP_000537:p.Arg175Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,23.20806,0.8199251890182495,3.81122,1.440629852761694,13.50964,12.324344926380848,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.025,0.85908,,,,,0.59934,,,2.1,,True,2.1,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,96.38,-,-0.4219,0.1023,-22.2419,-6.99788038686524,0.7297744245899348,Pathogenic,0.9977,pathogenic,-4.49,available,https://doi.org/10.1101/2022.10.22.513328 +C176A,NP_000537:p.Cys176Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.52289,0.4153066277503967,0.05442,0.0766019387148947,3.7886550000000003,3.7997459693574474,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,0.23276,,,,,0.0226,,,4.8,,False,4.8,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,96.44,-,-0.4887,0.042,-22.2419,-4.93975593132497,0.8475624041160869,Pathogenic,0.9997,pathogenic,-4.581,available,https://doi.org/10.1101/2022.10.22.513328 +C176D,NP_000537:p.Cys176Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.18292,-0.2484064698219299,-6.84966,0.3775958106874766,-1.83337,1.7802579053437384,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.032,0.95,,,,,1.29272,,,4.8,,False,4.8,,neutral,neutral,neutral,-,uncertain,damaging,True,neutral,neutral,96.44,-,-0.5959,0.042,-22.2419,-8.23221353167741,0.8675522644058249,Pathogenic,0.9998,pathogenic,-4.8,available,https://doi.org/10.1101/2022.10.22.513328 +C176E,NP_000537:p.Cys176Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.3349,1.5446059703826904,-3.22041,1.1570161490129105,0.557245,2.745958074506455,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,False,0.032,1.69026,,,,,1.12548,,,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.5835,0.042,-22.2419,-8.23221353167741,0.8689997824316511,Pathogenic,1.0,pathogenic,-4.832,available,https://doi.org/10.1101/2022.10.22.513328 +C176F,NP_000537:p.Cys176Phe,"hg19,17:g.7578402_7578403delinsAA, hg19,17:g.7578403C>A, hg19,17:g.7675085C>A, hg38,17:g.7675084_7675085delinsAA, hg38,17:g.7675085C>A",,3.9795609748e-06,0.951,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376569,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,20.19174,0.073647916316986,1.81531,1.185956361530981,11.003525,10.68884818076549,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,1.78108,-0.33416,Uncertain,,,0.94271,-0.3138,Neutral,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.4826,0.042,-22.2419,-7.79483400731286,0.8702760474222173,Pathogenic,0.999,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176G,NP_000537:p.Cys176Gly,"hg19,17:g.7578404A>C, hg19,17:g.7675086A>C, hg38,17:g.7675086A>C",,,0.946,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376571,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.97102,0.943386971950531,1.59796,1.0910211319058056,4.78449,4.531020565952903,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,0.37348,0.10887,Neutral,,,-0.15096,-0.29846,Neutral,4.8,,False,4.8,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,96.44,-,-0.4811,0.042,-22.2419,-8.23221353167741,0.8578531622345413,Pathogenic,0.999,pathogenic,-4.632,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176H,NP_000537:p.Cys176His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,25.69388,0.4282407760620117,0.02619,0.9052269592960732,12.860035,13.299553479648036,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,1.68276,,,,,0.84785,,,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.5266,0.042,-8.9541,-7.32313789200967,0.1293479251583714,Benign,0.9995,pathogenic,-4.272,available,https://doi.org/10.1101/2022.10.22.513328 +C176I,NP_000537:p.Cys176Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.64006,0.5442212820053101,3.83299,0.9629627977196722,6.736525,5.301511398859836,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,1.10464,,,,,0.13146,,,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.5125,0.042,-22.2419,-8.23221353167741,0.869842654789464,Pathogenic,0.9998,pathogenic,-4.722,available,https://doi.org/10.1101/2022.10.22.513328 +C176K,NP_000537:p.Cys176Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.98426,1.0530471801757812,4.73401,2.233298687541535,7.859135,6.608779343770768,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,2.8705,,,,,-0.25612,,,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.5841,0.042,-22.2419,-8.23221353167741,0.8670218090629438,Pathogenic,1.0,pathogenic,-4.792,available,https://doi.org/10.1101/2022.10.22.513328 +C176L,NP_000537:p.Cys176Leu,"hg19,17:g.7578402_7578403delinsTA, hg19,17:g.7578403_7578404delinsAG",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.09442,0.6995930671691895,3.03027,0.8369922079165881,8.062345,6.9657061039582935,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,0.32386,0.17145,Neutral,,,0.27334,0.85105,Neutral,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.5456,0.042,-22.2419,-8.23221353167741,0.8677963051580875,Pathogenic,0.9993,pathogenic,-4.602,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176M,NP_000537:p.Cys176Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.35381,0.6879690885543823,0.86735,1.0049763751151826,4.61058,4.679393187557591,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,1.5397,,,,,0.25229,,,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.5128,0.042,-22.2419,-8.23221353167741,0.870007911639635,Pathogenic,0.9998,pathogenic,-4.711,available,https://doi.org/10.1101/2022.10.22.513328 +C176N,NP_000537:p.Cys176Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.12782,0.0119608044624328,-0.96701,0.2041182605042074,4.580405,5.165969130252104,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,-0.18792,,,,,-0.19677,,,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.5383,0.042,-22.2419,-8.23221353167741,0.8705661557306118,Pathogenic,0.9999,pathogenic,-4.68,available,https://doi.org/10.1101/2022.10.22.513328 +C176P,NP_000537:p.Cys176Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.25062,0.1879199147224426,2.19082,3.900833752940308,5.72072,6.575726876470154,Uncertain,Destabilizing,Neutral,Destabilizing,Destabilizing,False,0.032,0.14806,,,,,0.03463,,,4.8,,False,4.8,,neutral,neutral,neutral,-,uncertain,damaging,True,neutral,neutral,96.44,-,-0.607,0.042,-22.2419,-8.23221353167741,0.8705425558578439,Pathogenic,0.9997,pathogenic,-4.76,available,https://doi.org/10.1101/2022.10.22.513328 +C176Q,NP_000537:p.Cys176Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,11.2102,1.1153039932250977,0.22211,1.0760594858810817,5.7161550000000005,6.143129742940541,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,1.48224,,,,,0.49516,,,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.5623,0.042,-22.2419,-8.23221353167741,0.8694632753052041,Pathogenic,1.0,pathogenic,-4.73,available,https://doi.org/10.1101/2022.10.22.513328 +C176R,NP_000537:p.Cys176Arg,"hg19,17:g.7578402_7578404delinsCCG, hg19,17:g.7578404A>G, hg19,17:g.7675086A>G, hg38,17:g.7675084_7675086delinsCCG, hg38,17:g.7675086A>G",,,0.940,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","634759, 376573","Likely pathogenic, Conflicting classifications of pathogenicity","0, 1",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.7444,0.9662927985191344,3.97823,1.7607408789723578,8.361315000000001,7.252570439486179,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,0.4918,-0.06601,Neutral,,,-0.14429,0.75232,Neutral,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.5409,0.042,-22.2419,-8.23221353167741,0.7787886911920763,Pathogenic,0.9999,pathogenic,-4.472,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176S,NP_000537:p.Cys176Ser,"hg19,17:g.7578402_7578403delinsAG, hg19,17:g.7578403C>G, hg19,17:g.7578404A>T, hg19,17:g.7675085C>G, hg19,17:g.7675086A>T, hg38,17:g.7675085C>G, hg38,17:g.7675086A>T, hg38,17:g.7675086_7675087delinsTA",,,"0.945, 0.946","cBioPortal,COSMIC,ClinVar,saturation_mutlist",376570,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,5.94103,-0.2467967867851257,-0.63095,0.5135329078900536,2.6550399999999996,3.2272814539450265,Uncertain,Uncertain,Neutral,Uncertain,Destabilizing,False,0.032,0.3043,0.05049,Neutral,,,0.02911,-0.1346,Neutral,4.8,,False,4.8,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,96.44,-,-0.4116,0.042,-8.9541,-4.93975593132497,0.8708488859765695,Pathogenic,0.9997,pathogenic,-4.462,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176T,NP_000537:p.Cys176Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.16112,0.9614258408546448,1.83435,0.5354846787881398,5.9977350000000005,5.3483023393940705,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,0.54216,,,,,-0.14758,,,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.5141,0.042,-22.2419,-4.93975593132497,0.8708611291193729,Pathogenic,0.9999,pathogenic,-4.643,available,https://doi.org/10.1101/2022.10.22.513328 +C176V,NP_000537:p.Cys176Val,"hg19,17:g.7578403_7578404delinsAC",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.51166,0.8373007774353027,2.73197,0.2827966568710555,8.121815,6.897228328435527,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,0.707,0.06644,Neutral,,,0.11212,0.11451,Neutral,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.5106,0.042,-22.2419,-8.23221353167741,0.8708143264476187,Pathogenic,0.9997,pathogenic,-4.627,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176W,NP_000537:p.Cys176Trp,"hg19,17:g.7578402G>C, hg19,17:g.7675084G>C, hg38,17:g.7675084G>C",,0.0,0.863,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376572,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,23.65274,0.1777905821800232,3.11497,0.9995708076834714,13.383855,12.326155403841737,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,2.3592,-0.41636,Uncertain,,,3.32325,0.60597,Uncertain,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.4858,0.042,-22.2419,-7.79483400731286,0.8629961834897071,Pathogenic,0.9993,pathogenic,-4.652,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C176Y,NP_000537:p.Cys176Tyr,"hg19,17:g.7578403C>T, hg19,17:g.7675085C>T, hg38,17:g.7675085C>T",,,0.949,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",186451,Pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,24.51268,0.3159685730934143,3.60374,1.328338239835393,14.058209999999999,12.920509119917696,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.032,0.90898,-0.28762,Neutral,,,0.82008,0.66483,Neutral,4.8,,False,4.8,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,96.44,-,-0.492,0.042,-22.2419,-7.79483400731286,0.8684118041381633,Pathogenic,0.9994,pathogenic,-4.51,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177A,NP_000537:p.Pro177Ala,"hg19,17:g.7578401G>C, hg38,17:g.7675083G>C",,,0.866,"ClinVar,saturation_mutlist",2585883,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.20457,0.4881042242050171,1.15544,-0.0793440125650107,1.680005,1.0626129937174946,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.016,0.53824,,Uncertain,,Uncertain,-0.08144,,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,95.0,H,-0.3223,0.0589,-22.2419,-5.74498225218225,0.5352815203588073,Uncertain,0.9442,pathogenic,-3.804,available,https://doi.org/10.1101/2022.10.22.513328 +P177C,NP_000537:p.Pro177Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.81336,0.4927051663398742,2.43435,0.6391139263882492,2.623855,1.7262369631941246,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.016,0.28132,,Uncertain,,Uncertain,-0.10397,,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,95.0,H,-0.355,0.0589,-22.2419,-6.36602491297949,0.8664227059498215,Pathogenic,0.9933,pathogenic,-4.311,available,https://doi.org/10.1101/2022.10.22.513328 +P177D,NP_000537:p.Pro177Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.23063,0.8185332417488098,1.15272,-0.5543016393431316,1.691675,0.8381641803284343,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.016,2.24976,,Uncertain,,Uncertain,1.12271,,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,95.0,H,-0.3809,0.0589,-22.2419,-7.48295067145383,0.8704042824955825,Pathogenic,0.9991,pathogenic,-4.324,available,https://doi.org/10.1101/2022.10.22.513328 +P177E,NP_000537:p.Pro177Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.53162,0.5325967669487,0.50068,-0.509513921071667,1.01615,0.5110530394641665,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,1.64,,Uncertain,,Uncertain,0.21279,,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,95.0,H,-0.3647,0.0589,-22.2419,-6.6080401806179,0.730669776976751,Pathogenic,0.9968,pathogenic,-4.207,available,https://doi.org/10.1101/2022.10.22.513328 +P177F,NP_000537:p.Pro177Phe,"hg19,17:g.7578400_7578401delinsAA, hg38,17:g.7675082_7675083delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.58504,0.8405576944351196,0.8051,-0.7089925223004406,1.6950699999999999,0.9380237388497796,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.016,-0.70256,-0.89276,Neutral,,Uncertain,-0.06383,0.20294,Neutral,51.1,,False,51.1,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,95.0,H,-0.3834,0.0589,-22.2419,-5.67897689218301,0.747731497163068,Pathogenic,0.9953,pathogenic,-4.288,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177G,NP_000537:p.Pro177Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.57234,1.0726608037948608,1.62245,0.4810524662517845,2.097395,1.5266962331258922,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.016,0.77662,,Uncertain,,Uncertain,0.02721,,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,95.0,H,-0.3366,0.0589,-22.2419,-8.0218864672828,0.8523687485385587,Pathogenic,0.993,pathogenic,-4.38,available,https://doi.org/10.1101/2022.10.22.513328 +P177H,NP_000537:p.Pro177His,"hg19,17:g.7578400G>T, hg19,17:g.7675082G>T, hg38,17:g.7675081_7675082delinsAT, hg38,17:g.7675082G>T",,,0.844,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",956854,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.04659,0.704782247543335,1.33197,-0.707150604033901,2.18928,1.1697196979830495,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.016,0.26942,-0.40785,Neutral,,Uncertain,-1.54188,-0.67655,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,95.0,H,-0.361,0.0589,-22.2419,-5.18672710714455,0.5803738565829757,Uncertain,0.9769,pathogenic,-3.985,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177I,NP_000537:p.Pro177Ile,"hg38,17:g.7675082_7675083delinsAT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.21673,0.6835529208183289,1.53129,-0.3440401211810506,1.8740100000000002,0.9363449394094747,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.016,0.1449,-0.08063,Neutral,,Uncertain,-0.5408,0.15435,Neutral,51.1,,False,51.1,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,95.0,H,-0.3664,0.0589,-22.2419,-5.53892850552698,0.7858770196504259,Pathogenic,0.9819,pathogenic,-4.188,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177K,NP_000537:p.Pro177Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.59034,0.8032105565071106,1.37891,-0.4919955006340643,1.9846249999999999,1.0491722496829679,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.016,0.13648,,Uncertain,,Uncertain,-1.23166,,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,95.0,H,-0.3563,0.0589,-22.2419,-6.92303379444111,0.869440850396133,Pathogenic,0.9954,pathogenic,-4.377,available,https://doi.org/10.1101/2022.10.22.513328 +P177L,NP_000537:p.Pro177Leu,"hg19,17:g.7578399_7578400delinsAA, hg19,17:g.7578400G>A, hg19,17:g.7675082G>A, hg38,17:g.7675081_7675082delinsAA, hg38,17:g.7675082G>A",,3.9793076005e-06,0.865,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406583,Conflicting classifications of pathogenicity,1,Uncertain significance,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.84176,0.658039391040802,1.42653,-0.7577943366660872,1.6341450000000002,0.5419828316669564,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,-0.41568,-0.30663,Neutral,,Uncertain,-0.39111,-0.15015,Neutral,51.1,,False,51.1,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,95.0,H,-0.371,0.0589,-22.2419,-5.21377652326031,0.1751516844548883,Benign,0.9256,pathogenic,-3.776,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177M,NP_000537:p.Pro177Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.96655,0.7208097577095032,1.18673,-0.3960016134073135,1.57664,0.7852741932963433,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,-0.94912,,Uncertain,,Uncertain,-0.30934,,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,95.0,H,-0.322,0.0589,-22.2419,-5.8221259721004,0.7745890402522604,Pathogenic,0.9905,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328 +P177N,NP_000537:p.Pro177Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.63833,0.8424040079116821,1.56259,-0.3400603563597093,2.10046,1.1491348218201454,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.016,-0.3422,,Uncertain,,Uncertain,-0.30155,,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,95.0,H,-0.349,0.0589,-22.2419,-7.48295067145383,0.8703397884371771,Pathogenic,0.9975,pathogenic,-4.311,available,https://doi.org/10.1101/2022.10.22.513328 +P177Q,NP_000537:p.Pro177Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.91776,0.6836181879043579,1.40068,-0.0970960745490229,1.65922,0.9103319627254886,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,0.91146,,Uncertain,,Uncertain,-0.90205,,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,95.0,H,-0.3507,0.0589,-22.2419,-7.48295067145383,0.8625492575619975,Pathogenic,0.9875,pathogenic,-4.069,available,https://doi.org/10.1101/2022.10.22.513328 +P177R,NP_000537:p.Pro177Arg,"hg19,17:g.7578400G>C, hg19,17:g.7675082G>C, hg38,17:g.7675082G>C",,0.0,0.893,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458547,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.87763,0.907554566860199,1.38197,-0.593800984732844,2.1298,1.141914507633578,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.016,-0.1306,-0.77037,Neutral,,Uncertain,-1.4307,-0.63831,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,95.0,H,-0.3243,0.0589,-8.9541,-6.44304391163323,0.817385674750621,Pathogenic,0.9661,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177S,NP_000537:p.Pro177Ser,"hg19,17:g.7578401G>A, hg19,17:g.7675083G>A, hg38,17:g.7675083G>A",,,0.877,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",646495,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.51011,0.6967131495475769,1.36156,-0.1199991283661572,1.935835,1.1950554358169214,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.016,1.13286,0.24621,Uncertain,,Uncertain,-0.29782,-0.11768,Neutral,51.1,,False,51.1,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,95.0,H,-0.2491,0.0589,-7.9541,-5.86050146488935,0.7119701149400479,Pathogenic,0.9845,pathogenic,-3.885,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177T,NP_000537:p.Pro177Thr,"hg19,17:g.7578401G>T, hg19,17:g.7675083G>T, hg38,17:g.7675083G>T",,,0.878,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",482220,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.85708,0.9265316724777222,1.55816,-0.0929531664724148,2.20762,1.3820634167637924,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.016,0.80204,-0.03364,Neutral,,Uncertain,-0.53625,0.16848,Neutral,51.1,,False,51.1,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,95.0,H,-0.3341,0.0589,-22.2419,-6.28883422013193,0.7732105001708429,Pathogenic,0.978,pathogenic,-4.044,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P177V,NP_000537:p.Pro177Val,"hg38,17:g.7675081_7675083delinsCAC",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.53988,0.799144983291626,1.32109,-0.1684679551097606,1.930485,1.1857060224451197,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.016,-0.12082,,Uncertain,,Uncertain,-0.42937,,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,95.0,H,-0.3218,0.0589,-22.2419,-5.46003183608147,0.4374821948059262,Uncertain,0.9678,pathogenic,-4.082,available,https://doi.org/10.1101/2022.10.22.513328 +P177W,NP_000537:p.Pro177Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.10414,0.6441951990127563,0.72415,-1.0634882783836168,1.914145,1.0203258608081915,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.016,0.44926,,Uncertain,,Uncertain,-0.08167,,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,95.0,H,-0.3959,0.0589,-22.2419,-6.55968231030577,0.8707412256392333,Pathogenic,0.9959,pathogenic,-4.659,available,https://doi.org/10.1101/2022.10.22.513328 +P177Y,NP_000537:p.Pro177Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.78466,0.6239338517189026,0.6949,-0.6080693125429004,1.73978,1.0882953437285499,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.016,1.62174,,Uncertain,,Uncertain,-0.04917,,Uncertain,51.1,,False,51.1,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,95.0,H,-0.3844,0.0589,-22.2419,-6.3926303538684,0.8135704555410429,Pathogenic,0.9945,pathogenic,-4.298,available,https://doi.org/10.1101/2022.10.22.513328 +H178A,NP_000537:p.His178Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.09024,0.2395756840705871,-0.24728,0.5623159588932466,-0.16876,0.2360379794466233,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.20384,,Uncertain,,Uncertain,3.41155,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,94.74,H,-0.2016,1.0379,-22.2419,-4.95611026951591,0.6555096965378207,Uncertain,0.9942,pathogenic,-3.977,available,https://doi.org/10.1101/2022.10.22.513328 +H178C,NP_000537:p.His178Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.54138,0.0214666128158569,0.84762,1.3352481625458026,0.6945,0.9383140812729013,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.18648,,Uncertain,,Uncertain,3.37873,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,94.74,H,-0.2561,1.0379,-22.2419,-5.6845487765731,0.8324060212218808,Pathogenic,0.942,pathogenic,-4.133,available,https://doi.org/10.1101/2022.10.22.513328 +H178D,NP_000537:p.His178Asp,"hg19,17:g.7578398G>C, hg19,17:g.7675080G>C, hg38,17:g.7675080G>C",,,0.892,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",482223,Pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.55854,0.5166686773300171,-0.00986,0.5271659228898268,-0.2842,-0.01568703855508663,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,1.3063,1.56866,Destabilizing,,Uncertain,6.35048,2.66491,Destabilizing,92.5,,False,92.5,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,94.74,H,-0.2488,1.0379,-22.2419,-4.01982276158121,0.8674708756181666,Pathogenic,0.9988,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H178E,NP_000537:p.His178Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.53163,0.2785255908966064,-5.37959,0.2045027244457298,-3.45561,-0.6635636377771351,Uncertain,Neutral,Neutral,Stabilizing,Neutral,False,0.015,0.93516,,Uncertain,,Uncertain,3.24269,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,94.74,H,-0.2603,1.0379,-22.2419,-4.01982276158121,0.8707319850721207,Pathogenic,0.9991,pathogenic,-4.245,available,https://doi.org/10.1101/2022.10.22.513328 +H178F,NP_000537:p.His178Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.00694,0.1047061681747436,0.03844,-0.1393153862898627,-0.48424999999999996,-0.5731276931449313,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-1.5731,,Uncertain,,Uncertain,2.21754,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.74,H,-0.2232,1.0379,-22.2419,-4.31420048674115,0.8314027261379388,Pathogenic,0.9358,pathogenic,-4.037,available,https://doi.org/10.1101/2022.10.22.513328 +H178G,NP_000537:p.His178Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48224,0.7608815431594849,0.83469,1.279093336273003,0.6584650000000001,0.8806666681365015,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.6386,,Uncertain,,Uncertain,4.02386,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,94.74,H,-0.2841,1.0379,-22.2419,-5.86878639637885,0.8024246580066932,Pathogenic,0.9965,pathogenic,-4.02,available,https://doi.org/10.1101/2022.10.22.513328 +H178I,NP_000537:p.His178Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.76979,0.0014148354530334,-0.22517,-0.0494194359347838,-0.49748,-0.4096047179673919,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.50734,,Uncertain,,Uncertain,3.16521,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.74,H,-0.2878,1.0379,-22.2419,-4.80953211986514,0.4572442716686671,Uncertain,0.9893,pathogenic,-3.926,available,https://doi.org/10.1101/2022.10.22.513328 +H178K,NP_000537:p.His178Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.25626,0.3533087968826294,-0.10646,0.3619033567735558,-0.18136,0.0528216783867779,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.4709,,Uncertain,,Uncertain,4.07108,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.74,H,-0.2445,1.0379,-22.2419,-6.54826484089745,0.8701766080400031,Pathogenic,0.9974,pathogenic,-4.09,available,https://doi.org/10.1101/2022.10.22.513328 +H178L,NP_000537:p.His178Leu,"hg19,17:g.7578397T>A, hg38,17:g.7675079T>A",,,0.843,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.86919,0.1715938448905944,-0.37721,-0.1803956921139854,-0.6232,-0.5247928460569927,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.45606,0.09894,Neutral,,Uncertain,3.47027,2.5453,Destabilizing,92.5,,False,92.5,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.74,H,-0.2514,1.0379,-22.2419,-4.78633146478376,0.2352829985126827,Benign,0.9223,pathogenic,-3.776,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H178M,NP_000537:p.His178Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.85567,0.2854577302932739,-0.16837,0.1601534785983127,-0.51202,-0.3477582607008437,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.9436,,Uncertain,,Uncertain,1.92363,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.74,H,-0.2015,1.0379,-22.2419,-5.61236611934688,0.8369289085395977,Pathogenic,0.99,pathogenic,-4.123,available,https://doi.org/10.1101/2022.10.22.513328 +H178N,NP_000537:p.His178Asn,"hg19,17:g.7578398G>T, hg38,17:g.7675080G>T",,,0.722,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",421546,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.43281,0.3847752213478088,-0.04728,0.6126593628535648,0.192765,0.5227346814267824,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.32208,0.92659,Neutral,,Uncertain,2.48671,2.26222,Destabilizing,92.5,,False,92.5,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,94.74,H,-0.0989,1.0379,-0.8147,-2.16847537029545,0.0274639830779874,Benign,0.9457,pathogenic,-3.29,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H178P,NP_000537:p.His178Pro,"hg19,17:g.7578397T>G, hg38,17:g.7675079T>G",,,0.918,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",485030,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.6059,0.8924511671066284,3.17993,2.71189185660879,1.287015,1.052995928304395,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.015,-0.21728,0.33579,Neutral,,Uncertain,3.06471,2.3596,Destabilizing,92.5,,False,92.5,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,94.74,H,-0.3648,1.0379,-22.2419,-6.94912649278667,0.8226450287003313,Pathogenic,0.9813,pathogenic,-4.325,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H178Q,NP_000537:p.His178Gln,"hg19,17:g.7578396G>C, hg19,17:g.7578396G>T, hg19,17:g.7675078G>T, hg38,17:g.7675078G>C, hg38,17:g.7675078G>T",,,0.814,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","947223, 575702","Pathogenic/Likely pathogenic, Pathogenic/Likely pathogenic","2, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.38894,0.3156174421310425,-0.32959,0.5234423248305187,-0.359265,0.06725116241525933,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.18376,0.03555,Neutral,,Uncertain,4.27656,2.54795,Destabilizing,92.5,,False,92.5,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,94.74,H,-0.1698,1.0379,-22.2419,-3.64554007785688,0.4295374303540418,Uncertain,0.9953,pathogenic,-3.823,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H178R,NP_000537:p.His178Arg,"hg19,17:g.7578397T>C, hg38,17:g.7675079T>C",,,0.882,"cBioPortal,ClinVar,saturation_mutlist",2780373,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.05584,0.2893947958946228,0.2602,0.0963331982242698,0.10217999999999999,0.020246599112134903,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-1.85746,,Uncertain,,Uncertain,5.14045,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.74,H,-0.2379,1.0379,-22.2419,-5.86482744817569,0.8174109132435935,Pathogenic,0.9907,pathogenic,-4.101,available,https://doi.org/10.1101/2022.10.22.513328 +H178S,NP_000537:p.His178Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.58019,0.4127293825149536,0.33095,0.6895175599593967,0.45557000000000003,0.6348537799796983,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.35882,,Uncertain,,Uncertain,2.705,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,94.74,H,-0.2075,1.0379,-22.2419,-5.02560375433689,0.4869245274539865,Uncertain,0.9867,pathogenic,-3.78,available,https://doi.org/10.1101/2022.10.22.513328 +H178T,NP_000537:p.His178Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35268,0.3915119767189026,0.15544,0.4422258428499331,0.25406,0.3974529214249666,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.38694,,Uncertain,,Uncertain,2.50689,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,94.74,H,-0.1846,1.0379,-8.9541,-3.73985535730397,0.1076288212504749,Benign,0.9929,pathogenic,-3.708,available,https://doi.org/10.1101/2022.10.22.513328 +H178V,NP_000537:p.His178Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15148,0.0361908674240112,-0.2,0.1705555798092994,-0.17574,0.009537789904649693,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.16086,,Uncertain,,Uncertain,3.4246,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,94.74,H,-0.2442,1.0379,-22.2419,-4.95214696049574,0.5670510901653264,Uncertain,0.9864,pathogenic,-3.969,available,https://doi.org/10.1101/2022.10.22.513328 +H178W,NP_000537:p.His178Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.38442,0.0241726636886596,-0.67755,-0.8013285593037534,-1.030985,-1.0928742796518767,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-1.13426,,Uncertain,,Uncertain,6.32331,,Uncertain,92.5,,False,92.5,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.74,H,-0.2395,1.0379,-22.2419,-4.5273237823316,0.868863205936934,Pathogenic,0.9512,pathogenic,-4.427,available,https://doi.org/10.1101/2022.10.22.513328 +H178Y,NP_000537:p.His178Tyr,"hg38,17:g.7675080G>A, hg38,17:g.7675080_7675081delinsAA",,,0.870,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.88008,-0.0522804856300354,-0.20204,-0.1390483381883112,-0.54106,-0.5095641690941556,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.8049,-0.55268,Neutral,,Uncertain,3.26626,1.73827,Destabilizing,92.5,,False,92.5,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.74,H,-0.1005,1.0379,-7.9541,-2.74682518781133,0.5859165950189872,Uncertain,0.9159,pathogenic,-3.802,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179A,NP_000537:p.His179Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.95229,1.1895880699157717,2.45952,0.677701144707013,4.705905,3.8149955723535065,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.031,0.18802,,,,,0.28727,,,20.1,,False,20.1,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,94.02,H,-0.2877,0.1023,-22.2419,-7.96459988094222,0.8199062659917653,Pathogenic,0.9996,pathogenic,-4.138,available,https://doi.org/10.1101/2022.10.22.513328 +H179C,NP_000537:p.His179Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.98294,0.8823689818382263,1.89762,1.2673779137287402,1.44028,1.12515895686437,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.06836,,,,,0.19829,,,20.1,,False,20.1,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,damaging,94.02,H,-0.3422,0.1023,-22.2419,-7.96459988094222,0.8608753046783912,Pathogenic,0.9878,pathogenic,-4.092,available,https://doi.org/10.1101/2022.10.22.513328 +H179D,NP_000537:p.His179Asp,"hg19,17:g.7578395G>C, hg19,17:g.7675077G>C, hg38,17:g.7675077G>C",,,0.916,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376610,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.39411,1.852047085762024,-5.77517,0.5145345261023218,-2.69053,0.45432226305116086,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.031,0.85616,0.40023,Neutral,,,0.99798,0.18728,Neutral,20.1,,False,20.1,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,94.02,H,-0.3349,0.1023,-22.2419,-7.69757186110331,0.8073299519110599,Pathogenic,0.9985,pathogenic,-4.021,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179E,NP_000537:p.His179Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.05452,1.5288039445877075,-3.54388,0.4834184429102278,-1.2446800000000002,0.7689692214551138,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.031,1.09388,,,,,0.8193,,,20.1,,False,20.1,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,94.02,H,-0.3464,0.1023,-22.2419,-7.69757186110331,0.8646702189840025,Pathogenic,0.9992,pathogenic,-4.358,available,https://doi.org/10.1101/2022.10.22.513328 +H179F,NP_000537:p.His179Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.61028,1.140389919281006,-0.15102,-0.4831380972302018,4.229629999999999,4.063570951384899,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.031,-0.26244,,,,,-0.28719,,,20.1,,False,20.1,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,94.02,H,-0.3093,0.1023,-22.2419,-4.77994467744306,0.8625773414660352,Pathogenic,0.9988,pathogenic,-4.264,available,https://doi.org/10.1101/2022.10.22.513328 +H179G,NP_000537:p.His179Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.62509,2.183156490325928,4.08707,1.6031955011789707,5.85608,4.614142750589485,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.031,0.557,,,,,0.28649,,,20.1,,False,20.1,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,94.02,H,-0.3702,0.1023,-22.2419,-7.96459988094222,0.8656727466100131,Pathogenic,0.9994,pathogenic,-4.322,available,https://doi.org/10.1101/2022.10.22.513328 +H179I,NP_000537:p.His179Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.80259,1.3458701372146606,2.31531,0.2214305524744186,6.05895,5.012010276237209,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.031,-0.04678,,,,,0.04296,,,20.1,,False,20.1,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,94.02,H,-0.3739,0.1023,-22.2419,-6.97647879047374,0.852473096295685,Pathogenic,0.9998,pathogenic,-4.443,available,https://doi.org/10.1101/2022.10.22.513328 +H179K,NP_000537:p.His179Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.59361,1.3118410110473633,1.96565,1.0145916869590423,4.77963,4.304100843479521,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.031,-0.04918,,,,,-0.88106,,,20.1,,False,20.1,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,94.02,H,-0.3306,0.1023,-22.2419,-7.96459988094222,0.838518660770261,Pathogenic,0.9972,pathogenic,-4.389,available,https://doi.org/10.1101/2022.10.22.513328 +H179L,NP_000537:p.His179Leu,"hg19,17:g.7578394T>A, hg19,17:g.7675076T>A, hg38,17:g.7675076T>A",,,0.882,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376608,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.96512,1.343174934387207,0.43912,-0.3464513506608674,3.70212,3.309334324669566,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.031,-0.17284,0.07709,Neutral,,,0.21109,0.13979,Neutral,20.1,,False,20.1,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,94.02,H,-0.2578,0.1023,-6.6322,-4.01906621514473,0.0017068321623512,Benign,0.996,pathogenic,-3.642,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179M,NP_000537:p.His179Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.10527,1.361349105834961,0.91088,0.0470607750885082,4.008075,3.576165387544254,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.031,-0.30904,,,,,-0.60446,,,20.1,,False,20.1,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,94.02,H,-0.2876,0.1023,-22.2419,-6.97647879047374,0.8672856496971705,Pathogenic,0.9994,pathogenic,-4.303,available,https://doi.org/10.1101/2022.10.22.513328 +H179N,NP_000537:p.His179Asn,"hg19,17:g.7578395G>T, hg19,17:g.7675077G>T, hg38,17:g.7675077G>T",,3.9792442619e-06,0.902,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376609,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.84411,0.7812860012054443,0.5517,0.4111029677300193,3.197905,3.1276064838650095,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.031,-0.00766,0.25466,Neutral,,,0.34609,0.18977,Neutral,20.1,,False,20.1,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,94.02,H,-0.2944,0.1023,-22.2419,-7.69757186110331,0.5807464034444547,Uncertain,0.9987,pathogenic,-3.971,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179P,NP_000537:p.His179Pro,"hg19,17:g.7578394T>G, hg19,17:g.7675076T>G, hg38,17:g.7675076T>G",,,0.911,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376611,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.17851,1.0704200267791748,9.45476,3.1706147472925448,9.316635,6.174562373646272,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.031,0.34656,0.48202,Neutral,,,0.54857,0.12748,Neutral,20.1,,False,20.1,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,94.02,H,-0.4509,0.1023,-22.2419,-7.96459988094222,0.8061541515835262,Pathogenic,0.9947,pathogenic,-4.291,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179Q,NP_000537:p.His179Gln,"hg19,17:g.7578393A>C, hg19,17:g.7578393A>T, hg19,17:g.7675075A>C, hg19,17:g.7675075A>T, hg38,17:g.7675075A>C, hg38,17:g.7675075A>T",,0.0,0.790,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","406578, 376607","Pathogenic, Pathogenic/Likely pathogenic","3, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.42658,1.1303472518920898,-0.39898,0.5778389706270448,3.5138000000000003,4.002209485313522,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.031,0.12236,0.35076,Neutral,,,0.17336,0.30013,Neutral,20.1,,False,20.1,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,94.02,H,-0.1881,0.1023,-8.9541,-7.69757186110331,0.8620551083824842,Pathogenic,0.999,pathogenic,-4.083,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179R,NP_000537:p.His179Arg,"hg19,17:g.7578394T>C, hg19,17:g.7675076T>C, hg38,17:g.7675076T>C",,3.9786743057e-06,0.935,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376606,Conflicting classifications of pathogenicity,1,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,8.23784,1.2889039516448977,2.75952,0.6757696570397032,5.49868,4.456804828519852,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.031,-0.65918,-0.42482,Neutral,,,-0.31116,0.47175,Neutral,20.1,,False,20.1,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,94.02,H,-0.324,0.1023,-22.2419,-7.96459988094222,0.8467102023767425,Pathogenic,0.9963,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H179S,NP_000537:p.His179Ser,"hg19,17:g.7578394_7578395delinsCT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.43723,1.328356385231018,1.15646,1.003954096758065,4.296844999999999,4.220592048379032,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.031,0.27878,,,,,0.27624,,,20.1,,False,20.1,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,94.02,H,-0.2936,0.1023,-22.2419,-7.96459988094222,0.830593271067767,Pathogenic,0.9994,pathogenic,-4.132,available,https://doi.org/10.1101/2022.10.22.513328 +H179T,NP_000537:p.His179Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.99245,1.975881099700928,1.66735,0.7375518004024334,4.3299,3.8650009002012164,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.031,-0.0372,,,,,0.23097,,,20.1,,False,20.1,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,94.02,H,-0.3384,0.1023,-22.2419,-7.96459988094222,0.8562595611296209,Pathogenic,0.9997,pathogenic,-4.299,available,https://doi.org/10.1101/2022.10.22.513328 +H179V,NP_000537:p.His179Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.39495,1.5185526609420776,1.85646,0.4363023859666676,5.625705,4.915626192983334,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.031,0.2307,,,,,0.2452,,,20.1,,False,20.1,,neutral,neutral,neutral,DOWN,destabilizing,damaging,True,neutral,neutral,94.02,H,-0.3303,0.1023,-22.2419,-6.97647879047374,0.8369816923507047,Pathogenic,0.9997,pathogenic,-4.273,available,https://doi.org/10.1101/2022.10.22.513328 +H179W,NP_000537:p.His179Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.27685,0.980744242668152,-0.55748,-0.5253636498926106,3.359685,3.3757431750536946,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.031,-0.22276,,,,,-0.31994,,,20.1,,False,20.1,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,94.02,H,-0.3255,0.1023,-22.2419,-4.77994467744306,0.855720128041686,Pathogenic,0.9918,pathogenic,-4.376,available,https://doi.org/10.1101/2022.10.22.513328 +H179Y,NP_000537:p.His179Tyr,"hg19,17:g.7578395G>A, hg19,17:g.7578395_7578396delinsAA, hg19,17:g.7675077G>A, hg38,17:g.7675077G>A, hg38,17:g.7675077_7675078delinsAA",,,0.948,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127815,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,9.25013,0.298098087310791,0.43571,-0.0958604387203299,4.84292,4.5771347806398355,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.031,-0.15454,-0.23222,Neutral,,,-0.87798,-0.59266,Neutral,20.1,,False,20.1,,neutral,neutral,neutral,UP,stabilizing,damaging,True,neutral,neutral,94.02,H,-0.2595,0.1023,-22.2419,-4.77994467744306,0.8518424845510366,Pathogenic,0.9976,pathogenic,-4.201,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E180A,NP_000537:p.Glu180Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.33305,0.8655282855033875,-0.30136,0.2262188112593155,0.015844999999999998,0.27963440562965775,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,-0.45152,,Uncertain,,Uncertain,-0.39999,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,92.98,H,-0.2742,0.5049,-22.2419,-4.24894450660188,0.4085367068285335,Uncertain,0.8966,pathogenic,-3.695,available,https://doi.org/10.1101/2022.10.22.513328 +E180C,NP_000537:p.Glu180Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.86595,0.9403998255729676,1.22925,0.8589181020996323,1.0476,0.8624340510498161,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,-0.44704,,Uncertain,,Uncertain,-0.38024,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,92.98,H,-0.3436,0.5049,-22.2419,-4.84480144585992,0.8201895045962253,Pathogenic,0.9957,pathogenic,-4.168,available,https://doi.org/10.1101/2022.10.22.513328 +E180D,NP_000537:p.Glu180Asp,"hg19,17:g.7578390C>A, hg19,17:g.7578390C>G, hg38,17:g.7675072C>A, hg38,17:g.7675072C>G",,,0.798,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","1521256, 1509915","Uncertain significance, Uncertain significance","2, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.84174,1.348316311836243,0.69082,0.9126679885845352,0.7662800000000001,0.8772039942922676,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.024,0.27388,0.1068,Neutral,,Uncertain,0.2661,-0.15082,Neutral,42.2,,False,42.2,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,92.98,H,-0.2399,0.5049,-22.2419,-4.01310292969903,0.8680269035924145,Pathogenic,0.9843,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E180F,NP_000537:p.Glu180Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.71345,1.3213919401168823,0.78163,-0.592290902328208,0.03409000000000001,-0.652870451164104,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.024,-0.51882,,Uncertain,,Uncertain,-0.49273,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,92.98,H,-0.3212,0.5049,-22.2419,-7.17653783134478,0.8546346991778355,Pathogenic,0.9983,pathogenic,-4.302,available,https://doi.org/10.1101/2022.10.22.513328 +E180G,NP_000537:p.Glu180Gly,"hg19,17:g.7578391T>C, hg38,17:g.7675073T>C",,,0.915,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.6635,1.74224853515625,1.27211,1.2698172416218252,1.467805,1.4666586208109127,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.024,-0.39148,0.08626,Neutral,,Uncertain,-0.34875,-0.13471,Neutral,42.2,,False,42.2,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,92.98,H,-0.3,0.5049,-22.2419,-7.17653783134478,0.8623303232396292,Pathogenic,0.9391,pathogenic,-4.038,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E180H,NP_000537:p.Glu180His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.86781,1.387523174285889,0.5119,-0.0111862756238895,0.689855,0.4283118621880552,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.024,-0.47048,,Uncertain,,Uncertain,-0.50083,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,92.98,H,-0.3125,0.5049,-22.2419,-7.17653783134478,0.8690976436163388,Pathogenic,0.9961,pathogenic,-4.157,available,https://doi.org/10.1101/2022.10.22.513328 +E180I,NP_000537:p.Glu180Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.57052,0.860816240310669,0.05748,-0.433134430666181,-0.25652,-0.5018272153330905,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,-0.22234,,Uncertain,,Uncertain,-0.33311,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,92.98,H,-0.3265,0.5049,-22.2419,-4.60879661175175,0.5260646786796487,Uncertain,0.9876,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328 +E180K,NP_000537:p.Glu180Lys,"hg19,17:g.7578392C>T, hg19,17:g.7675074C>T, hg38,17:g.7675074C>T",,,0.823,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",245711,Likely pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.10706,1.5066447257995603,0.15952,0.4105650303174885,0.13329,0.25881251515874426,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.024,-0.62634,0.29869,Neutral,,Uncertain,-0.67995,0.09146,Neutral,42.2,,False,42.2,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,92.98,H,-0.2962,0.5049,-22.2419,-4.89923646247751,0.3452811995524725,Uncertain,0.9545,pathogenic,-3.778,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E180L,NP_000537:p.Glu180Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.99159,1.0870600938796997,-0.05408,-0.7416907160674907,-0.5228349999999999,-0.8666403580337454,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.024,-0.52074,,Uncertain,,Uncertain,-0.36602,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,92.98,H,-0.2609,0.5049,-8.9541,-5.14403974319505,0.5822336053576234,Uncertain,0.9876,pathogenic,-3.893,available,https://doi.org/10.1101/2022.10.22.513328 +E180M,NP_000537:p.Glu180Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.93781,0.8631922602653503,0.30204,-0.2459197593694823,-0.31788500000000003,-0.5918648796847412,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,-0.52302,,Uncertain,,Uncertain,-0.43956,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,92.98,H,-0.2775,0.5049,-22.2419,-4.68654595280717,0.5819912889764463,Uncertain,0.9785,pathogenic,-3.974,available,https://doi.org/10.1101/2022.10.22.513328 +E180N,NP_000537:p.Glu180Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.27642,1.6818197965621948,0.88197,0.5248152069776341,1.0791950000000001,0.9006176034888171,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.024,-0.47636,,Uncertain,,Uncertain,-0.42992,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,92.98,H,-0.3004,0.5049,-22.2419,-3.81278750080609,0.8698214707781948,Pathogenic,0.9947,pathogenic,-4.195,available,https://doi.org/10.1101/2022.10.22.513328 +E180P,NP_000537:p.Glu180Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.21906,2.581190586090088,6.81973,5.611176656369252,6.019394999999999,5.415118328184626,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.024,0.72812,,Uncertain,,Uncertain,0.72714,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,92.98,H,-0.4312,0.5049,-22.2419,-7.17653783134478,0.8691903460644173,Pathogenic,0.9995,pathogenic,-4.286,available,https://doi.org/10.1101/2022.10.22.513328 +E180Q,NP_000537:p.Glu180Gln,"hg19,17:g.7675074C>G, hg38,17:g.7675074C>G",,,0.659,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.06389,0.6535782814025879,-0.02585,0.3072385337286565,0.019020000000000002,0.18556426686432825,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,-0.46598,0.12067,Neutral,,Uncertain,-0.32102,0.19077,Neutral,42.2,,False,42.2,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,92.98,H,-0.1498,0.5049,-3.2538,-1.95332187981058,0.0001743311622279,Benign,0.6972,pathogenic,-3.327,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E180R,NP_000537:p.Glu180Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.55801,1.5317139625549316,0.37585,-0.1277970887812052,0.46693,0.2151064556093974,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.024,-0.99944,,Uncertain,,Uncertain,-1.0019,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,92.98,H,-0.3567,0.5049,-22.2419,-4.93206584285295,0.5420297420236151,Uncertain,0.9686,pathogenic,-3.83,available,https://doi.org/10.1101/2022.10.22.513328 +E180S,NP_000537:p.Glu180Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.49508,1.047865390777588,1.18844,0.8807769047669312,1.3417599999999998,1.1879284523834657,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.024,-0.45724,,Uncertain,,Uncertain,-0.36958,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,92.98,H,-0.2877,0.5049,-22.2419,-4.40461122679346,0.3506083855064047,Uncertain,0.939,pathogenic,-3.79,available,https://doi.org/10.1101/2022.10.22.513328 +E180T,NP_000537:p.Glu180Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.7437,0.8402212262153625,0.88163,0.420563360358801,1.312665,1.0821316801794005,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,-0.46802,,Uncertain,,Uncertain,-0.3765,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,92.98,H,-0.3035,0.5049,-22.2419,-4.13869447516391,0.6174368821993717,Uncertain,0.9784,pathogenic,-3.847,available,https://doi.org/10.1101/2022.10.22.513328 +E180V,NP_000537:p.Glu180Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.20986,0.9032830595970154,-0.26224,-0.2084017817861105,-0.02618999999999999,0.0007291091069447503,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,-0.46854,,Uncertain,,Uncertain,-0.42709,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,92.98,H,-0.2874,0.5049,-22.2419,-4.6438588596269,0.4989284553408514,Uncertain,0.9619,pathogenic,-3.828,available,https://doi.org/10.1101/2022.10.22.513328 +E180W,NP_000537:p.Glu180Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.21568,1.2948710918426514,0.12857,-0.9227471692199168,0.172125,-0.35353358460995843,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.024,-0.73746,,Uncertain,,Uncertain,-0.62506,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,92.98,H,-0.3313,0.5049,-22.2419,-7.17653783134478,0.8483671215329049,Pathogenic,0.9995,pathogenic,-4.451,available,https://doi.org/10.1101/2022.10.22.513328 +E180Y,NP_000537:p.Glu180Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.51129,1.327472686767578,0.36667,-0.3842245357354679,-0.07231000000000001,-0.44775726786773395,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.024,-0.5008,,Uncertain,,Uncertain,-0.55981,,Uncertain,42.2,,False,42.2,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,92.98,H,-0.322,0.5049,-22.2419,-7.17653783134478,0.8708251560894527,Pathogenic,0.9977,pathogenic,-4.379,available,https://doi.org/10.1101/2022.10.22.513328 +R181A,NP_000537:p.Arg181Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.27177,0.1420855522155761,0.64626,0.4907914264851143,0.45901499999999995,0.3812807132425572,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.3592,,Uncertain,,Uncertain,1.78575,,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.2828,1.3753,-22.1457,-2.99280489319979,0.0619878403162466,Benign,0.9365,pathogenic,-3.692,available,https://doi.org/10.1101/2022.10.22.513328 +R181C,NP_000537:p.Arg181Cys,"hg19,17:g.7578389G>A, hg19,17:g.7675071G>A, hg38,17:g.7675066_7675071delinsACAGCA, hg38,17:g.7675071G>A",,,0.891,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142624,Likely pathogenic,3,Likely oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,-0.02287,0.2504644989967346,1.12483,1.0690403556477774,0.55098,0.5230851778238887,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.28606,0.22805,Uncertain,,Uncertain,1.44069,0.03521,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.2121,1.3753,-6.536,-1.68475225689632,0.000101097600815,Benign,0.7821,pathogenic,-3.339,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R181D,NP_000537:p.Arg181Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.25523,0.7140105962753296,1.09456,0.5736208443939391,0.674895,0.41442542219696954,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.4657,,Uncertain,,Uncertain,2.21184,,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.3739,1.3753,-22.1457,-3.56772637753279,0.030766082322392,Benign,0.969,pathogenic,-3.941,available,https://doi.org/10.1101/2022.10.22.513328 +R181E,NP_000537:p.Arg181Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.17717,0.5679587125778198,0.74796,0.4343140237049114,0.28539499999999995,0.1285720118524557,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.50814,,Uncertain,,Uncertain,2.12901,,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.2513,1.3753,-8.8578,-3.46318427497821,0.1114022919730102,Benign,0.918,pathogenic,-3.844,available,https://doi.org/10.1101/2022.10.22.513328 +R181F,NP_000537:p.Arg181Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.13058,0.5460298657417297,0.60408,-0.0088966706378712,0.36733,0.0608416646810644,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.01684,,Uncertain,,Uncertain,1.48859,,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.315,1.3753,-22.1457,-4.74866784766429,0.1690713846894409,Benign,0.9698,pathogenic,-3.8,available,https://doi.org/10.1101/2022.10.22.513328 +R181G,NP_000537:p.Arg181Gly,"hg38,17:g.7675071G>C",,,0.886,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48158,0.5380796790122986,1.20374,1.0647430224415333,0.84266,0.7731615112207666,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.34932,0.61346,Uncertain,,Uncertain,1.87329,0.04482,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.3182,1.3753,-22.1457,-3.40908290573761,0.107222187780725,Benign,0.8319,pathogenic,-3.671,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R181H,NP_000537:p.Arg181His,"hg19,17:g.7578388C>T, hg19,17:g.7675070C>T, hg38,17:g.7675070C>T",3.1843077315e-05,1.19367827983e-05,0.797,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142320,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22542,0.4119423627853393,0.54082,0.1500715930485335,0.38312,0.18774579652426676,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,1.90044,0.3325,Uncertain,,Uncertain,1.25554,-0.22698,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.2526,1.3753,-22.1457,-4.6132577539881,0.3965586030513996,Uncertain,0.5897,pathogenic,-3.598,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R181I,NP_000537:p.Arg181Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.72696,0.4116791486740112,0.63912,0.0363344327946651,0.6830400000000001,0.38164721639733257,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.30396,,Uncertain,,Uncertain,1.05089,,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.3123,1.3753,-22.1457,-1.85661734121558,0.0897232349098313,Benign,0.8978,pathogenic,-3.77,available,https://doi.org/10.1101/2022.10.22.513328 +R181K,NP_000537:p.Arg181Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.13621,0.0344940423965454,0.42177,0.2359086970064067,0.27898999999999996,0.18605934850320335,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,1.99476,,Uncertain,,Uncertain,1.35057,,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,91.38,S,-0.0972,1.3753,-7.273,-1.81007855970178,0.0004786670712739,Benign,0.5021,ambiguous,-3.337,available,https://doi.org/10.1101/2022.10.22.513328 +R181L,NP_000537:p.Arg181Leu,"hg19,17:g.7578388C>A, hg38,17:g.7675070C>A",,,0.680,"COSMIC,ClinVar,saturation_mutlist",39420,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.00133,0.1336381435394287,0.32823,-0.2596080844561366,0.16478,-0.1291390422280683,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.30752,0.28083,Uncertain,,Uncertain,1.38916,0.03602,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.1811,1.3753,-1.7184,-1.78372764631026,0.0043008187038406,Benign,0.7789,pathogenic,-3.412,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R181M,NP_000537:p.Arg181Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01748,0.1255651712417602,0.59524,0.1084378019180137,0.28887999999999997,0.04547890095900685,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,1.88194,,Uncertain,,Uncertain,1.0839,,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.2511,1.3753,-22.1457,-2.83108413970769,0.1861717151039591,Benign,0.92,pathogenic,-3.786,available,https://doi.org/10.1101/2022.10.22.513328 +R181N,NP_000537:p.Arg181Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.28916,0.3621283769607544,0.35918,0.3604919530978867,0.03501000000000001,0.03566597654894335,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.36494,,Uncertain,,Uncertain,1.7908,,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.2146,1.3753,-5.858,-2.40137883804777,0.0002277299330921,Benign,0.9303,pathogenic,-3.434,available,https://doi.org/10.1101/2022.10.22.513328 +R181P,NP_000537:p.Arg181Pro,"hg19,17:g.7578388C>G, hg19,17:g.7675070C>G, hg38,17:g.7675070C>G",,,0.894,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",825729,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.44565,1.900953769683838,6.48299,4.735538118923139,3.96432,3.0905940594615693,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.027,2.64788,0.40048,Uncertain,,Uncertain,2.47332,0.28363,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.4249,1.3753,-22.1457,-5.89424882966398,0.7018334935995721,Pathogenic,0.9881,pathogenic,-4.159,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R181Q,NP_000537:p.Arg181Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.3429,0.1807467341423034,0.58469,0.4032716176363871,0.12089500000000003,0.03018580881819355,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.02724,,Uncertain,,Uncertain,1.38894,,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.1817,1.3753,-7.273,-2.10064191078992,0.0055681241093766,Benign,0.5038,ambiguous,-3.462,available,https://doi.org/10.1101/2022.10.22.513328 +R181S,NP_000537:p.Arg181Ser,"hg19,17:g.7578389G>T, hg38,17:g.7675071G>T",,,0.778,"COSMIC,ClinVar,saturation_mutlist",230764,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.24036,0.310633897781372,0.67551,0.6102525313556764,0.21757500000000002,0.18494626567783817,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.3208,0.44106,Uncertain,,Uncertain,1.95287,0.43037,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.2003,1.3753,-5.858,-1.95985419143055,0.0001757125516154,Benign,0.9524,pathogenic,-3.302,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R181T,NP_000537:p.Arg181Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.75395,0.4853472113609314,0.61122,0.3980864416906615,0.682585,0.5760182208453307,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.3611,,Uncertain,,Uncertain,1.95472,,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.2118,1.3753,-7.273,-2.36815356608492,0.0159835905115538,Benign,0.9137,pathogenic,-3.516,available,https://doi.org/10.1101/2022.10.22.513328 +R181V,NP_000537:p.Arg181Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.92643,0.5037840604782104,0.48095,0.2718984706380356,0.7036899999999999,0.5991642353190179,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.31514,,Uncertain,,Uncertain,1.23247,,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.2993,1.3753,-22.1457,-2.5224692505029,0.115550468681366,Benign,0.9178,pathogenic,-3.764,available,https://doi.org/10.1101/2022.10.22.513328 +R181W,NP_000537:p.Arg181Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.41355,0.5889636874198914,0.75272,-0.2340716373284124,0.583135,0.08973918133579378,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,1.29124,,Uncertain,,Uncertain,1.4328,,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.3006,1.3753,-22.1457,-5.03969650820416,0.6411163165895126,Uncertain,0.8386,pathogenic,-4.079,available,https://doi.org/10.1101/2022.10.22.513328 +R181Y,NP_000537:p.Arg181Tyr,,,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.19013,0.580463171005249,0.54932,0.193211545493136,0.369725,0.191670772746568,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,2.32566,0.02172,Uncertain,,Uncertain,1.46944,-0.0072,Uncertain,87.9,,True,87.9,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,91.38,S,-0.3043,1.3753,-22.1457,-4.7566485774957,0.3591119399125625,Uncertain,0.9175,pathogenic,-3.899,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C182A,NP_000537:p.Cys182Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.56441,-0.0686733722686767,-0.3932,-0.3809876375845428,-0.478805,-0.4726988187922714,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.14468,,Uncertain,,Uncertain,0.49432,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.1743,2.5602,-6.0413,-1.40169309573315,7.640333182724883e-07,Benign,0.303,benign,-3.03,available,https://doi.org/10.1101/2022.10.22.513328 +C182D,NP_000537:p.Cys182Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.17678,0.1826817989349365,-0.25204,0.162935534818106,-0.03763,0.169857767409053,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.6822,,Uncertain,,Uncertain,1.47089,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,83.44,S,-0.3637,2.5602,-22.1363,-3.64964588715357,0.0337831422603337,Benign,0.6467,pathogenic,-3.4,available,https://doi.org/10.1101/2022.10.22.513328 +C182E,NP_000537:p.Cys182Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.20733,0.0718193054199218,0.88435,-0.2734202693045223,0.33851,-0.24037513465226112,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.86868,,Uncertain,,Uncertain,1.36047,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.247,2.5602,-1.6989,-2.61964780497236,9.259827978399064e-05,Benign,0.8029,pathogenic,-3.2,available,https://doi.org/10.1101/2022.10.22.513328 +C182F,NP_000537:p.Cys182Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.8031,0.191442608833313,-0.48844,-0.7926743719875678,-0.64577,-0.7978871859937839,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.04558,,Uncertain,,Uncertain,-0.68548,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.1826,2.5602,-8.8485,-4.62916087876924,0.1083533310360335,Benign,0.2808,benign,-3.679,available,https://doi.org/10.1101/2022.10.22.513328 +C182G,NP_000537:p.Cys182Gly,"hg19,17:g.7578386A>C, hg38,17:g.7675068A>C",,,0.644,"ClinVar,saturation_mutlist",1489700,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.18902,0.3680942952632904,0.13095,0.8262304012840738,-0.02903499999999999,0.3186052006420369,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.2672,0.02491,Neutral,,Uncertain,0.52986,-0.07591,Neutral,52.4,,True,52.4,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.1494,2.5602,-2.6392,-2.06513563086665,2.313041774144643e-06,Benign,0.1252,benign,-3.152,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C182H,NP_000537:p.Cys182His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.34561,0.0580275058746337,0.83878,-0.5137112421484319,0.246585,-0.42966062107421593,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.01718,,Uncertain,,Uncertain,0.04941,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.2892,2.5602,-7.8486,-3.21479375180572,0.0010122956634087,Benign,0.56,ambiguous,-3.327,available,https://doi.org/10.1101/2022.10.22.513328 +C182I,NP_000537:p.Cys182Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.35391,-0.2001519799232483,0.47007,-1.0401191541139103,0.05807999999999999,-0.6970145770569551,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,-0.02756,,Uncertain,,Uncertain,-0.20472,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.1981,2.5602,-6.0413,-2.69484183510495,3.757687414509226e-06,Benign,0.5509,ambiguous,-3.27,available,https://doi.org/10.1101/2022.10.22.513328 +C182K,NP_000537:p.Cys182Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.43799,-0.3345609307289123,-0.52891,-0.4095716396015575,-0.48345,-0.42378081980077875,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,-0.13608,,Uncertain,,Uncertain,-0.28241,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.2841,2.5602,-8.8485,-3.9008857468304,0.0014970021626311,Benign,0.8636,pathogenic,-3.284,available,https://doi.org/10.1101/2022.10.22.513328 +C182L,NP_000537:p.Cys182Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.542,-0.2515560984611511,-0.87415,-1.2490176433448874,-0.708075,-0.8955088216724437,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.15606,,Uncertain,,Uncertain,-0.3578,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.3133,2.5602,-22.1363,-3.68642896791747,0.0036471676624154,Benign,0.4904,ambiguous,-3.306,available,https://doi.org/10.1101/2022.10.22.513328 +C182M,NP_000537:p.Cys182Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.49526,-0.2548789381980896,-0.37143,-0.6754258608666025,-0.433345,-0.5853429304333012,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.0347,,Uncertain,,Uncertain,-0.90883,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.2806,2.5602,-22.1363,-3.79588949024381,0.0094789820175674,Benign,0.5763,pathogenic,-3.371,available,https://doi.org/10.1101/2022.10.22.513328 +C182N,NP_000537:p.Cys182Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.31811,-0.0200774669647216,0.00476,-0.1846346800562287,-0.156675,-0.25137234002811437,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.00814,,Uncertain,,Uncertain,0.42119,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.2302,2.5602,-7.2636,-2.11975898210649,2.508595334841552e-06,Benign,0.2772,benign,-3.078,available,https://doi.org/10.1101/2022.10.22.513328 +C182P,NP_000537:p.Cys182Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.31963,1.1879229545593262,6.57857,4.823342769603638,4.9491,4.071486384801819,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.054,0.16306,,Uncertain,,Uncertain,0.45371,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,83.44,S,-0.3747,2.5602,-22.1363,-3.37186841537745,0.0048656164633919,Benign,0.8677,pathogenic,-3.251,available,https://doi.org/10.1101/2022.10.22.513328 +C182Q,NP_000537:p.Cys182Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.00105,-0.2936671376228332,-0.51122,-0.2685768859988624,-0.255085,-0.13376344299943121,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.03496,,Uncertain,,Uncertain,0.31304,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.2622,2.5602,-8.8485,-2.67364994098795,0.0004155100475135,Benign,0.6167,pathogenic,-3.247,available,https://doi.org/10.1101/2022.10.22.513328 +C182R,NP_000537:p.Cys182Arg,"hg19,17:g.7578386A>G, hg38,17:g.7675068A>G",,,0.644,"COSMIC,ClinVar,saturation_mutlist",2774651,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.49597,-0.3636693358421325,-0.94558,-0.7818698751726033,-0.7207749999999999,-0.6389199375863017,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,-0.49228,-0.26436,Neutral,,Uncertain,-0.33867,-0.42481,Neutral,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.2328,2.5602,-7.2636,-2.38440899215391,3.3750833254013484e-06,Benign,0.577,pathogenic,-2.999,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C182S,NP_000537:p.Cys182Ser,"hg19,17:g.7578386A>T, hg38,17:g.7675067C>G, hg38,17:g.7675068A>T",,,"0.438, 0.455","COSMIC,ClinVar,saturation_mutlist",3572141,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.34098,0.0184148550033569,-0.73707,0.2078626982503612,-0.539025,-0.06655865087481941,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.00128,0.11333,Neutral,,Uncertain,0.23909,0.07263,Neutral,52.4,,True,52.4,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.1458,2.5602,-2.2788,-0.344315653188998,1.3941014372976027e-11,Benign,0.1432,benign,-2.836,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C182T,NP_000537:p.Cys182Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.3373,0.0277929902076721,-0.94082,-0.3406780728682801,-0.63906,-0.33898903643414,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,-0.04646,,Uncertain,,Uncertain,0.0743,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.1898,2.5602,-4.0937,-1.33982175602423,1.0723087595584234e-07,Benign,0.2763,benign,-2.957,available,https://doi.org/10.1101/2022.10.22.513328 +C182V,NP_000537:p.Cys182Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.18636,-0.0186203718185424,-0.11633,-0.9064017728210672,-0.151345,-0.5463808864105336,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,-0.0077,,Uncertain,,Uncertain,0.0673,,Uncertain,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.2024,2.5602,-7.2636,-2.78982489009814,0.0001042574263544,Benign,0.3973,ambiguous,-3.212,available,https://doi.org/10.1101/2022.10.22.513328 +C182W,NP_000537:p.Cys182Trp,"hg19,17:g.7578384G>C, hg38,17:g.7675066G>C",,,0.659,"COSMIC,ClinVar,saturation_mutlist",423137,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.4117,0.1891049742698669,0.57177,-1.0808279829854466,0.080035,-0.7462639914927233,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.12976,-0.09587,Neutral,,Uncertain,-0.23147,-0.03735,Neutral,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.2535,2.5602,-22.1363,-4.62916087876924,0.2466861246727657,Benign,0.6232,pathogenic,-3.77,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C182Y,NP_000537:p.Cys182Tyr,"hg38,17:g.7675067C>T",,,0.634,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.59817,0.2563740015029907,0.01156,-0.6290085915069565,-0.293305,-0.6135892957534783,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,0.15582,0.21254,Neutral,,Uncertain,-0.48653,-0.22434,Neutral,52.4,,True,52.4,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,83.44,S,-0.1919,2.5602,-8.8485,-4.62916087876924,0.0065436094973952,Benign,0.4342,ambiguous,-3.495,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S183A,NP_000537:p.Ser183Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.4791,-0.1002583503723144,0.43503,0.2092751253178715,0.957065,0.8441875626589358,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,0.0,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,68.18,-,0.0407,2.5172,-4.6818,-1.50041483373061,8.08465906524806e-07,Benign,0.0844,benign,-2.991,available,https://doi.org/10.1101/2022.10.22.513328 +S183C,NP_000537:p.Ser183Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.46787,-0.2246715426445007,0.91088,0.7457063870747654,1.189375,1.1067881935373827,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,-0.00542,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.0988,2.5172,-22.1395,-1.40670628281605,0.0293441388240085,Benign,0.1329,benign,-3.48,available,https://doi.org/10.1101/2022.10.22.513328 +S183D,NP_000537:p.Ser183Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.24762,-0.0488428473472595,-0.13776,-0.2995273919639069,-0.19269,-0.27357369598195347,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,0.15598,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.0649,2.5172,-6.0444,-0.92525206734369,9.836407936122858e-06,Benign,0.5895,pathogenic,-3.133,available,https://doi.org/10.1101/2022.10.22.513328 +S183E,NP_000537:p.Ser183Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.26348,0.0049402117729187,-0.03707,-0.1744525267466973,-0.150275,-0.21896626337334865,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,0.11687,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.0355,2.5172,-5.5298,-1.90539837217322,0.0002356916117145,Benign,0.6969,pathogenic,-3.282,available,https://doi.org/10.1101/2022.10.22.513328 +S183F,NP_000537:p.Ser183Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.19791,0.0945205688476562,0.33163,-0.0222373806697129,0.06685999999999999,-0.11007369033485645,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,0.0,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.0222,2.5172,-1.7225,-4.67543076910183,0.1651011140202038,Benign,0.3462,ambiguous,-3.756,available,https://doi.org/10.1101/2022.10.22.513328 +S183G,NP_000537:p.Ser183Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.51554,-0.019496738910675,0.1466,0.3531018548485226,-0.18447,-0.08121907257573871,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,0.001,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,DOWN,stabilizing,neutral,False,neutral,neutral,68.18,-,0.0246,2.5172,-6.0444,-2.36193507984271,4.226465861858864e-06,Benign,0.0997,benign,-3.104,available,https://doi.org/10.1101/2022.10.22.513328 +S183H,NP_000537:p.Ser183His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.3871,0.0743337869644165,-0.2119,-0.2896219247491816,-0.2995,-0.3383609623745908,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,-0.25107,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.1276,2.5172,-22.1395,-4.40292473143752,0.0002054561086059,Benign,0.5481,ambiguous,-3.47,available,https://doi.org/10.1101/2022.10.22.513328 +S183I,NP_000537:p.Ser183Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.09309,0.1277440786361694,0.62857,0.2071720757080597,0.26774,0.05704103785402985,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,0.0,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.1295,2.5172,-22.1395,-3.72579747263335,0.0299087116066322,Benign,0.302,benign,-3.579,available,https://doi.org/10.1101/2022.10.22.513328 +S183K,NP_000537:p.Ser183Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.84805,0.1037430763244628,0.05952,-0.1676640141647906,0.453785,0.3401929929176047,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,-0.2055,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.137,2.5172,-22.1395,-1.63696792972833,0.0022530878462351,Benign,0.8672,pathogenic,-3.439,available,https://doi.org/10.1101/2022.10.22.513328 +S183L,NP_000537:p.Ser183Leu,"hg19,17:g.7578382G>A, hg38,17:g.7675064G>A",,,0.556,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480735,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.48097,-0.0040902495384216,0.0966,-0.2322410369368643,0.788785,0.6243644815315678,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,0.0,0.07535,Neutral,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.0529,2.5172,-7.8517,-1.1839784203177,0.0011439951820378,Benign,0.1353,benign,-3.347,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S183M,NP_000537:p.Ser183Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.22829,0.05863618850708,0.44286,0.0166412335545701,0.10728499999999999,-0.10582438322271495,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,-0.01493,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.0239,2.5172,-7.8517,-2.50927661332166,0.0003663828388805,Benign,0.2572,benign,-3.516,available,https://doi.org/10.1101/2022.10.22.513328 +S183N,NP_000537:p.Ser183Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.23961,-0.0395797491073608,-0.28571,-0.2212866131431895,-0.26266,-0.23044830657159476,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,0.0,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,0.009,2.5172,-6.5298,-1.99451645324493,0.000104074367558,Benign,0.2328,benign,-3.212,available,https://doi.org/10.1101/2022.10.22.513328 +S183P,NP_000537:p.Ser183Pro,"hg19,17:g.7578383A>G, hg38,17:g.7675065A>G",,,0.457,"COSMIC,ClinVar,saturation_mutlist",3328150,Likely benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.91196,0.0077397227287292,-0.74966,0.7907455607603439,-0.83081,-0.06060721961982807,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,-0.05872,-0.06478,Neutral,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.1123,2.5172,-4.6038,-0.917250040714386,4.95141882247614e-07,Benign,0.1431,benign,-3.002,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S183Q,NP_000537:p.Ser183Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.01164,0.0911223292350769,0.1068,0.1055119451084707,0.55922,0.5585759725542354,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,-0.00507,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.0174,2.5172,-7.8517,-1.99930412205824,0.0019536878296764,Benign,0.6339,pathogenic,-3.31,available,https://doi.org/10.1101/2022.10.22.513328 +S183R,NP_000537:p.Ser183Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.65677,0.138538122177124,0.47483,-0.2264147442223713,0.5658,0.21517762788881434,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,-0.42266,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.038,2.5172,-1.7122,-1.57237522379816,0.0003056708184241,Benign,0.8145,pathogenic,-3.276,available,https://doi.org/10.1101/2022.10.22.513328 +S183T,NP_000537:p.Ser183Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.51932,0.0443688631057739,-0.12415,0.1495519429328906,0.697585,0.8344359714664453,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,0.0,,Uncertain,109.5,P,True,109.5,0.018,neutral,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,0.0431,2.5172,-6.0444,-0.543773160589435,2.7714036358741894e-07,Benign,0.0928,benign,-3.048,available,https://doi.org/10.1101/2022.10.22.513328 +S183V,NP_000537:p.Ser183Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.55045,0.1409173011779785,0.58231,0.2571856377443621,1.06638,0.903817818872181,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,0.0,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.0258,2.5172,-6.8517,-2.38764090355794,0.0005199387227,Benign,0.2396,benign,-3.285,available,https://doi.org/10.1101/2022.10.22.513328 +S183W,NP_000537:p.Ser183Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.41029,0.084886610507965,0.38061,-0.3082271844561418,0.8954500000000001,0.5510314077719292,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,0.07195,,Uncertain,109.5,P,True,109.5,0.018,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.1361,2.5172,-22.1395,-4.67543076910183,0.4994582358179026,Uncertain,0.5124,ambiguous,-3.941,available,https://doi.org/10.1101/2022.10.22.513328 +S183Y,NP_000537:p.Ser183Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.22716,0.1792157292366027,-0.06837,-0.0272488335989856,-0.147765,-0.1272044167994928,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,-0.08788,,Uncertain,109.5,P,True,109.5,0.018,uncertain,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,68.18,-,-0.1312,2.5172,-22.1395,-4.11716354669042,0.146856848063954,Benign,0.4008,ambiguous,-3.748,available,https://doi.org/10.1101/2022.10.22.513328 +D184A,NP_000537:p.Asp184Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.23817,0.6114133596420288,0.38231,0.8153036376463274,1.31024,1.5267368188231638,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.51857,-0.17741,Neutral,78.0,,True,78.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.1843,1.7859,-22.2332,-4.13100823428518,0.0785305757985768,Benign,0.3377,benign,-3.544,available,https://doi.org/10.1101/2022.10.22.513328 +D184C,NP_000537:p.Asp184Cys,"hg19,17:g.7578379_7578380delinsCA",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.88562,0.4055770635604858,1.45816,1.281030583381927,1.6718899999999999,1.5833252916909637,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.50801,-0.40921,Neutral,78.0,,True,78.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,69.78,-,-0.158,1.7859,-8.9453,-4.35135669521169,0.0005981641593137,Benign,0.702,pathogenic,-3.644,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D184E,NP_000537:p.Asp184Glu,"hg19,17:g.7578378A>T, hg38,17:g.7675060A>T",,,0.558,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22479,0.6482751965522766,-0.12925,0.4533573079841729,0.04776999999999999,0.33907365399208644,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.32778,-0.0394,Neutral,78.0,,True,78.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.0271,1.7859,-2.2175,-0.343448415506865,5.7841641899049986e-09,Benign,0.1615,benign,-2.859,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D184F,NP_000537:p.Asp184Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.06857,0.8744376301765442,0.34592,0.2701767747567052,0.207245,0.1693733873783526,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.74965,,Uncertain,78.0,,True,78.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.2845,1.7859,-22.2332,-4.55387540351303,0.2385008318923899,Benign,0.7036,pathogenic,-3.956,available,https://doi.org/10.1101/2022.10.22.513328 +D184G,NP_000537:p.Asp184Gly,"hg19,17:g.7578379T>C, hg38,17:g.7675061T>C",,,0.666,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406606,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.52627,0.6567970514297485,1.45986,1.4537003421211607,0.993065,0.9899851710605804,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.52706,0.09026,Neutral,78.0,,True,78.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.1196,1.7859,-7.3604,-2.86758815566188,8.665341501275222e-05,Benign,0.2792,benign,-3.123,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D184H,NP_000537:p.Asp184His,"hg19,17:g.7578380C>G, hg19,17:g.7675062C>G, hg38,17:g.7675062C>G",,,0.700,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2687701,Uncertain significance,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.54656,0.8409202098846436,-0.12551,0.0154878024375509,0.21052500000000002,0.28102390121877546,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.53297,-0.24688,Neutral,78.0,,True,78.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.1258,1.7859,-8.9453,-3.90031923608068,0.0051032790297124,Benign,0.5343,ambiguous,-3.458,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D184I,NP_000537:p.Asp184Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.33476,1.1514482498168943,0.02143,0.5580976130749373,0.178095,0.44642880653746864,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.49121,,Uncertain,78.0,,True,78.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.2767,1.7859,-22.2332,-4.15409404302754,0.1145243634211208,Benign,0.5842,pathogenic,-3.808,available,https://doi.org/10.1101/2022.10.22.513328 +D184K,NP_000537:p.Asp184Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.08894,1.150686264038086,0.54014,0.7962093000992018,1.31454,1.4425746500496008,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.61893,,Uncertain,78.0,,True,78.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.2551,1.7859,-22.2332,-4.5543551955672,0.1081488927739461,Benign,0.6912,pathogenic,-3.56,available,https://doi.org/10.1101/2022.10.22.513328 +D184L,NP_000537:p.Asp184Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.93507,0.9615116119384766,-0.04796,-0.1717501896023082,0.943555,0.881659905198846,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.50103,,Uncertain,78.0,,True,78.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.2703,1.7859,-22.2332,-3.12135022782395,0.0494995396543588,Benign,0.5756,pathogenic,-3.645,available,https://doi.org/10.1101/2022.10.22.513328 +D184M,NP_000537:p.Asp184Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.37571,0.8469996452331543,0.10272,0.1355997920002727,-0.13649499999999998,-0.12005510399986365,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.51778,,Uncertain,78.0,,True,78.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.2091,1.7859,-22.2332,-3.16389501613802,0.1623383646307422,Benign,0.7759,pathogenic,-3.825,available,https://doi.org/10.1101/2022.10.22.513328 +D184N,NP_000537:p.Asp184Asn,"hg19,17:g.7578380C>T, hg38,17:g.7675062C>T",,,0.433,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.52779,0.4382920265197754,-0.03878,0.1246885189872748,0.244505,0.3262392594936374,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.51092,-0.06038,Neutral,78.0,,True,78.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,69.78,-,-0.0449,1.7859,-1.4456,-2.67346273286837,0.0014756214431764,Benign,0.1931,benign,-3.33,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D184P,NP_000537:p.Asp184Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.99647,0.973912477493286,2.04286,3.3101224770929387,1.519665,2.1532962385464693,Uncertain,Uncertain,Neutral,Neutral,Uncertain,False,0.007,,,Uncertain,,Uncertain,-0.42459,,Uncertain,78.0,,True,78.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,69.78,-,-0.3213,1.7859,-22.2332,-5.37161229502735,0.3924484246597846,Uncertain,0.7166,pathogenic,-3.616,available,https://doi.org/10.1101/2022.10.22.513328 +D184Q,NP_000537:p.Asp184Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.01284,0.7899705767631531,-0.17007,0.5967427420112409,0.9213850000000001,1.3047913710056205,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.47372,,Uncertain,78.0,,True,78.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.1435,1.7859,-8.9453,-2.55781556587848,0.0719210154757306,Benign,0.5513,ambiguous,-3.482,available,https://doi.org/10.1101/2022.10.22.513328 +D184R,NP_000537:p.Asp184Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.15983,1.2050535678863523,0.6415,0.4024306785226078,1.400665,1.2811303392613038,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.76352,,Uncertain,78.0,,True,78.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.2183,1.7859,-8.9453,-4.27329689644672,0.0142855921563028,Benign,0.6854,pathogenic,-3.514,available,https://doi.org/10.1101/2022.10.22.513328 +D184S,NP_000537:p.Asp184Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.87263,0.3454592227935791,0.99014,0.7857612454468216,0.931385,0.8291956227234107,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.52312,,Uncertain,78.0,,True,78.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.1127,1.7859,-6.9454,-3.74160804452424,0.0363100307482636,Benign,0.2213,benign,-3.406,available,https://doi.org/10.1101/2022.10.22.513328 +D184T,NP_000537:p.Asp184Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.56205,0.7960646748542786,0.92041,0.9112891764802248,1.74123,1.7366695882401124,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.55143,,Uncertain,78.0,,True,78.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,69.78,-,-0.153,1.7859,-8.9453,-3.90179158913291,0.0416324070219145,Benign,0.3938,ambiguous,-3.614,available,https://doi.org/10.1101/2022.10.22.513328 +D184V,NP_000537:p.Asp184Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.41904,1.2079288959503174,0.25374,0.6056870824265217,1.33639,1.5123635412132608,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.53426,0.01794,Neutral,78.0,,True,78.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.2314,1.7859,-22.2332,-3.10883732625192,0.0268363840903444,Benign,0.3933,ambiguous,-3.586,available,https://doi.org/10.1101/2022.10.22.513328 +D184W,NP_000537:p.Asp184Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.40046,0.583433985710144,-0.57789,-0.1958491525876177,0.411285,0.6023054237061911,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.64768,,Uncertain,78.0,,True,78.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.2649,1.7859,-22.2332,-4.55387540351303,0.5412330812257584,Uncertain,0.9257,pathogenic,-4.127,available,https://doi.org/10.1101/2022.10.22.513328 +D184Y,NP_000537:p.Asp184Tyr,"hg38,17:g.7675062C>A",,,0.715,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.07421,0.9890861511230468,0.28367,0.3765819980414991,0.17894,0.22539599902074955,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,Uncertain,,Uncertain,-0.4539,-0.01511,Neutral,78.0,,True,78.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.78,-,-0.1513,1.7859,-6.9454,-1.812225626061,0.0548764689083884,Benign,0.451,ambiguous,-3.81,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185A,NP_000537:p.Ser185Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.03591,0.124933898448944,0.9034,-0.05409420441704,0.433745,-0.045002102208519995,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,67.73,-,0.0073,2.3904,-8.9541,-1.62880461624935,5.112932982034425e-05,Benign,0.1073,benign,-3.111,available,https://doi.org/10.1101/2022.10.22.513328 +S185C,NP_000537:p.Ser185Cys,"hg38,17:g.7675059T>A",,,0.425,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.93577,0.0689035654067993,0.93741,0.2055020699830945,0.0008199999999999874,-0.36513396500845274,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.111,2.3904,-22.2419,-3.51485496891826,0.1296969203286025,Benign,0.1144,benign,-3.638,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185D,NP_000537:p.Ser185Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.37987,0.0579188466072082,2.37381,0.2566388435585776,1.37684,0.31825442177928875,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.0914,2.3904,-8.9541,-2.13912657237141,0.0005427836939308,Benign,0.3869,ambiguous,-3.354,available,https://doi.org/10.1101/2022.10.22.513328 +S185E,NP_000537:p.Ser185Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.13718,0.2273289561271667,1.46463,0.4006182831861044,0.663725,0.1317191415930522,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.0268,2.3904,-1.5448,-1.31715398243916,3.6905182346360975e-06,Benign,0.5751,pathogenic,-3.17,available,https://doi.org/10.1101/2022.10.22.513328 +S185F,NP_000537:p.Ser185Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.93497,0.3797505497932434,0.3534,-0.7123768323523705,0.644185,0.11129658382381474,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.0433,2.3904,-3.5619,-3.22749031943694,0.0075187856799294,Benign,0.376,ambiguous,-3.392,available,https://doi.org/10.1101/2022.10.22.513328 +S185G,NP_000537:p.Ser185Gly,"hg38,17:g.7675059T>C",,,0.497,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.39616,0.3495563268661499,2.18061,0.6899996191318333,1.2883850000000001,0.5430798095659166,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,DOWN,stabilizing,neutral,False,neutral,neutral,67.73,-,0.0231,2.3904,-4.0473,-0.766135825224233,6.980049260636952e-10,Benign,0.0635,benign,-2.834,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185H,NP_000537:p.Ser185His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.07752,0.3187951445579529,1.19592,-0.3254340965745883,1.13672,0.37604295171270585,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.1398,2.3904,-22.2419,-3.71634779464388,0.0047648113307593,Benign,0.3539,ambiguous,-3.344,available,https://doi.org/10.1101/2022.10.22.513328 +S185I,NP_000537:p.Ser185Ile,"hg38,17:g.7675058C>A",,,0.452,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.27395,0.2948251366615295,0.15816,-0.802938912595208,-0.5578949999999999,-1.0384444562976038,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.1417,2.3904,-22.2419,-1.77177164818091,0.0176949123262931,Benign,0.2053,benign,-3.308,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185K,NP_000537:p.Ser185Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.67712,0.4464151263236999,1.17381,0.1851155081670596,0.24834499999999998,-0.24600224591647024,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.0695,2.3904,-6.6322,-1.60686075827579,3.7038293967409643e-07,Benign,0.7004,pathogenic,-3.178,available,https://doi.org/10.1101/2022.10.22.513328 +S185L,NP_000537:p.Ser185Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.59978,0.3303260803222656,-0.01224,-1.0721569950479852,-0.80601,-1.3359684975239925,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.138,2.3904,-22.2419,-4.41582752221782,0.0164444188381301,Benign,0.1892,benign,-3.445,available,https://doi.org/10.1101/2022.10.22.513328 +S185M,NP_000537:p.Ser185Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.22324,0.3020855188369751,0.42891,-0.6174964798534666,-0.39716500000000005,-0.9203682399267333,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.0361,2.3904,-7.9541,-2.62492258047863,0.0007586823517706,Benign,0.2443,benign,-3.287,available,https://doi.org/10.1101/2022.10.22.513328 +S185N,NP_000537:p.Ser185Asn,"hg19,17:g.7578376C>T, hg38,17:g.7675058C>T",,3.9786743057e-06,0.325,"COSMIC,ClinVar,saturation_mutlist",141359,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.26923,0.1928609609603881,1.32313,-0.3547993250300874,0.79618,-0.042784662515043675,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,0.0213,2.3904,-1.8249,0.116493607243856,1.4102517015406523e-10,Benign,0.0957,benign,-2.803,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185P,NP_000537:p.Ser185Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.88467,0.3374994993209839,6.75884,1.294760181747356,3.821755,1.089715090873678,Uncertain,Neutral,Neutral,Destabilizing,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.1462,2.3904,-8.9541,-3.21676365750743,0.0031768670953529,Benign,0.3448,ambiguous,-3.322,available,https://doi.org/10.1101/2022.10.22.513328 +S185Q,NP_000537:p.Ser185Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.71237,0.2153843641281128,0.0085,-0.0002916805359753,-0.351935,-0.3563308402679876,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.0347,2.3904,-8.9541,-1.56781595013197,0.0002662976257084,Benign,0.4911,ambiguous,-3.204,available,https://doi.org/10.1101/2022.10.22.513328 +S185R,NP_000537:p.Ser185Arg,"hg19,17:g.7578375G>C, hg38,17:g.7675057G>C, hg38,17:g.7675057G>T",,,0.520,"COSMIC,ClinVar,saturation_mutlist",1748280,Likely benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.66566,0.4882820546627044,-0.08367,-0.3941096216098194,-0.374665,-0.5298848108049097,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.0785,2.3904,-7.3692,-2.1883691405826,0.0023156931656036,Benign,0.6104,pathogenic,-3.306,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185T,NP_000537:p.Ser185Thr,"hg38,17:g.7675057_7675058delinsCG",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.22047,0.2324191331863403,-0.20714,0.0189128298208102,-0.213805,-0.1007785850895949,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,neutral,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,0.0309,2.3904,-6.1468,-1.53198523946946,1.0979120339077929e-05,Benign,0.0858,benign,-3.06,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S185V,NP_000537:p.Ser185Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.75298,0.3723512887954712,-0.1966,-0.5952734238679308,-0.47479,-0.6741267119339653,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.0482,2.3904,-8.9541,-2.83257197794757,0.0028330619426754,Benign,0.2128,benign,-3.322,available,https://doi.org/10.1101/2022.10.22.513328 +S185W,NP_000537:p.Ser185Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.51486,0.2368444204330444,0.56429,-0.8532222309897208,1.0395750000000001,0.33081888450513963,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,damaging,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.1483,2.3904,-22.2419,-4.22792953630984,0.1951451222165565,Benign,0.5161,ambiguous,-3.774,available,https://doi.org/10.1101/2022.10.22.513328 +S185Y,NP_000537:p.Ser185Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.59141,0.4384650588035583,0.20646,-0.4745704340799755,0.398935,0.05841978296001224,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,41.0,P,True,41.0,0.91,uncertain,neutral,potentially_damaging,UP,stabilizing,neutral,False,neutral,neutral,67.73,-,-0.0705,2.3904,-7.9541,-2.60875622288036,0.0314546800465435,Benign,0.3444,ambiguous,-3.388,available,https://doi.org/10.1101/2022.10.22.513328 +D186A,NP_000537:p.Asp186Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.73339,1.1050784587860107,2.79932,0.9789358419444107,1.766355,0.8561629209722054,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,69.29,-,-0.2046,1.5659,-22.239,-4.30897925100973,0.1067054553804836,Benign,0.6348,pathogenic,-3.593,available,https://doi.org/10.1101/2022.10.22.513328 +D186C,NP_000537:p.Asp186Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.25553,0.6714853048324585,2.52381,1.4520767015729483,2.3896699999999997,1.8538033507864742,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,69.29,-,-0.2461,1.5659,-22.239,-5.31085808942199,0.8118718569204268,Pathogenic,0.8978,pathogenic,-3.893,available,https://doi.org/10.1101/2022.10.22.513328 +D186E,NP_000537:p.Asp186Glu,"hg19,17:g.7578372A>T, hg38,17:g.7675054A>T",,3.9784843566e-06,0.643,"COSMIC,ClinVar,saturation_mutlist",230006,Likely benign,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.24547,1.195523023605347,2.40782,0.6763167512037196,1.326645,0.4608933756018598,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.29,-,-0.0604,1.5659,-4.7814,-0.647375049671803,2.796792722946493e-05,Benign,0.4078,ambiguous,-2.947,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D186F,NP_000537:p.Asp186Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.20474,1.1562817096710205,1.44966,0.424757234405797,1.8272,1.3147486172028986,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.29,-,-0.3047,1.5659,-22.239,-5.48755082177828,0.8136444300467076,Pathogenic,0.9112,pathogenic,-4.068,available,https://doi.org/10.1101/2022.10.22.513328 +D186G,NP_000537:p.Asp186Gly,"hg38,17:g.7675055T>C",,,0.680,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.10585,1.0323002338409424,3.54796,1.4270735373187142,2.826905,1.7664617686593571,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,69.29,-,-0.1116,1.5659,-1.822,-5.69946724771392,0.7663948996261345,Pathogenic,0.5048,ambiguous,-3.684,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D186H,NP_000537:p.Asp186His,"hg38,17:g.7675056C>G",,,0.692,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.76019,1.0751328468322754,2.13265,0.2236696597891574,1.44642,0.49192982989457873,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.29,-,-0.2139,1.5659,-22.239,-3.91172505625663,0.0687013020967681,Benign,0.803,pathogenic,-3.53,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D186I,NP_000537:p.Asp186Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.83575,1.42195463180542,1.98776,0.9957091582612034,1.9117549999999999,1.4157295791306017,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.29,-,-0.297,1.5659,-22.239,-5.46714163006275,0.7399772064464887,Pathogenic,0.8904,pathogenic,-3.864,available,https://doi.org/10.1101/2022.10.22.513328 +D186K,NP_000537:p.Asp186Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.21465,1.3026156425476074,3.02177,0.9567779676735174,2.61821,1.5857139838367587,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.29,-,-0.2753,1.5659,-22.239,-4.50583806841955,0.1293246949331405,Benign,0.8827,pathogenic,-3.657,available,https://doi.org/10.1101/2022.10.22.513328 +D186L,NP_000537:p.Asp186Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.38779,1.275656819343567,1.43844,0.3479170170094275,0.913115,0.36785350850471377,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.29,-,-0.2906,1.5659,-22.239,-5.25471483154328,0.5170391673677945,Uncertain,0.8285,pathogenic,-3.699,available,https://doi.org/10.1101/2022.10.22.513328 +D186M,NP_000537:p.Asp186Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.74737,1.3319056034088137,1.17347,0.6011819101150392,0.21305000000000002,-0.0730940449424804,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.29,-,-0.2294,1.5659,-22.239,-5.75187386230467,0.8705122248767049,Pathogenic,0.9369,pathogenic,-4.086,available,https://doi.org/10.1101/2022.10.22.513328 +D186N,NP_000537:p.Asp186Asn,"hg19,17:g.7578374C>T, hg38,17:g.7675056C>T",,7.957728546e-06,0.532,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406601,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.51676,0.3666843175888061,0.47449,0.1675870288255299,0.495625,0.34217351441276495,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,69.29,-,-0.0732,1.5659,-3.0206,-1.78942865852632,0.0576889928369687,Benign,0.3448,ambiguous,-3.262,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D186P,NP_000537:p.Asp186Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.45871,1.3290798664093018,2.66837,3.033656270980124,1.10483,1.287473135490062,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,69.29,-,-0.3416,1.5659,-22.239,-5.08249865396284,0.4575278139407727,Uncertain,0.8725,pathogenic,-3.635,available,https://doi.org/10.1101/2022.10.22.513328 +D186Q,NP_000537:p.Asp186Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.02952,1.3292186260223389,2.15646,0.8845754318132532,2.0929900000000004,1.4570477159066266,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.29,-,-0.2316,1.5659,-22.239,-3.05957110403163,0.3526359081521077,Uncertain,0.8221,pathogenic,-3.497,available,https://doi.org/10.1101/2022.10.22.513328 +D186R,NP_000537:p.Asp186Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.62861,1.2943072319030762,2.96769,0.7855471688807419,2.29815,1.2070785844403709,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.29,-,-0.3063,1.5659,-22.239,-3.45618973141325,0.0322971714307329,Benign,0.8559,pathogenic,-3.564,available,https://doi.org/10.1101/2022.10.22.513328 +D186S,NP_000537:p.Asp186Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.81119,0.58714759349823,1.74218,0.7599495806627404,1.276685,0.7855697903313702,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,69.29,-,-0.1381,1.5659,-7.9512,-3.5823531868822,0.0572049065537213,Benign,0.4325,ambiguous,-3.446,available,https://doi.org/10.1101/2022.10.22.513328 +D186T,NP_000537:p.Asp186Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.11186,1.0600425004959106,1.34626,1.065967808700128,1.72906,1.588913904350064,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,69.29,-,-0.241,1.5659,-22.239,-4.44569198926029,0.6668990342487736,Uncertain,0.659,pathogenic,-3.614,available,https://doi.org/10.1101/2022.10.22.513328 +D186V,NP_000537:p.Asp186Val,"hg38,17:g.7675055T>A",,,0.800,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.1892,1.5750993490219116,1.93605,1.0789154395953706,2.062625,1.6340577197976853,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.29,-,-0.2517,1.5659,-22.239,-5.75187386230467,0.7577473521752536,Pathogenic,0.7499,pathogenic,-3.76,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D186W,NP_000537:p.Asp186Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.35207,1.165029525756836,1.17551,0.2449120647299402,1.2637900000000002,0.7984910323649701,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.29,-,-0.2852,1.5659,-22.239,-5.48755082177828,0.8608548765921111,Pathogenic,0.9714,pathogenic,-4.302,available,https://doi.org/10.1101/2022.10.22.513328 +D186Y,NP_000537:p.Asp186Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.21695,1.3445591926574707,1.78503,0.4708515942979774,2.00099,1.3439007971489887,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,92.8,,True,92.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,69.29,-,-0.2496,1.5659,-22.239,-5.48755082177828,0.8507373884401419,Pathogenic,0.7262,pathogenic,-4.159,available,https://doi.org/10.1101/2022.10.22.513328 +G187A,NP_000537:p.Gly187Ala,"hg19,17:g.7578289C>G, hg38,17:g.7674971C>G",,,0.610,"ClinVar,saturation_mutlist",1479275,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.0806,0.7567829489707947,1.86122,0.4098616980728109,1.97091,1.2452308490364055,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.1286,1.8092,-4.8667,-1.7231937485443,6.24067825606827e-05,Benign,0.2047,benign,-3.14,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G187C,NP_000537:p.Gly187Cys,"hg19,17:g.7578371C>A, hg19,17:g.7675053C>A, hg38,17:g.7675053C>A",,,0.705,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.08847,0.5366814136505127,2.51463,1.122328117500309,2.3015499999999998,1.6053990587501545,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.2011,1.8092,-7.3692,-2.23517995208198,0.0178272437190742,Benign,0.2974,benign,-3.536,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G187D,NP_000537:p.Gly187Asp,"hg19,17:g.7578289C>T, hg38,17:g.7674971C>T",,,0.625,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",422532,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.75642,0.8357946276664734,1.38878,0.0141637292045554,1.5726,0.8852918646022777,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.1935,1.8092,-5.7843,-2.47844934009982,2.268585438648931e-07,Benign,0.4916,ambiguous,-3.198,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G187E,NP_000537:p.Gly187Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.15394,0.9173872470855712,1.72857,0.2160535606475849,1.941255,1.1849967803237924,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.2009,1.8092,-7.3692,-3.0470884145673,0.0079618195335704,Benign,0.5275,ambiguous,-3.358,available,https://doi.org/10.1101/2022.10.22.513328 +G187F,NP_000537:p.Gly187Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.01365,0.8721663951873779,1.5932,0.173357755941691,1.803425,1.0935038779708455,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.3151,1.8092,-22.2419,-5.57393330133001,0.538141978151259,Uncertain,0.6951,pathogenic,-4.022,available,https://doi.org/10.1101/2022.10.22.513328 +G187H,NP_000537:p.Gly187His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.17578,0.9185526967048644,1.29694,-0.0713489366836861,1.73636,1.052215531658157,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.2898,1.8092,-22.2419,-4.72958727003029,0.1985824591031813,Benign,0.627,pathogenic,-3.625,available,https://doi.org/10.1101/2022.10.22.513328 +G187I,NP_000537:p.Gly187Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.27549,1.093537449836731,5.28401,0.9196189167012804,3.77975,1.5975544583506402,Uncertain,Uncertain,Uncertain,Destabilizing,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.3607,1.8092,-22.2419,-5.2907994651809,0.338428186929777,Uncertain,0.4464,ambiguous,-3.958,available,https://doi.org/10.1101/2022.10.22.513328 +G187K,NP_000537:p.Gly187Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.00541,0.979617178440094,1.34932,-0.0858860846470715,1.677365,0.9597619576764642,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.3097,1.8092,-22.2419,-4.47806056422347,0.0273552140375972,Benign,0.8056,pathogenic,-3.623,available,https://doi.org/10.1101/2022.10.22.513328 +G187L,NP_000537:p.Gly187Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.07429,0.9709665179252625,1.73741,0.0639133055600382,1.90585,1.069101652780019,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.2612,1.8092,-8.9541,-3.66741501508662,0.08723123090266,Benign,0.5779,pathogenic,-3.682,available,https://doi.org/10.1101/2022.10.22.513328 +G187M,NP_000537:p.Gly187Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.81495,0.9493427276611328,2.26463,0.4043045646043586,2.03979,1.1096272823021793,Uncertain,Neutral,Neutral,Uncertain,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.1994,1.8092,-8.9541,-3.76120818651042,0.1917569780868795,Benign,0.6439,pathogenic,-3.826,available,https://doi.org/10.1101/2022.10.22.513328 +G187N,NP_000537:p.Gly187Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.03869,0.8317370414733887,0.92585,-0.1903235364835681,1.48227,0.9241832317582159,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.1957,1.8092,-6.1468,-2.59666971362815,0.0048306567758203,Benign,0.3905,ambiguous,-3.415,available,https://doi.org/10.1101/2022.10.22.513328 +G187P,NP_000537:p.Gly187Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.74477,1.223037600517273,6.73639,5.015254026763289,5.74058,4.880012013381645,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.3071,1.8092,-8.9541,-3.96536114774247,0.0206818584737298,Benign,0.8414,pathogenic,-3.648,available,https://doi.org/10.1101/2022.10.22.513328 +G187Q,NP_000537:p.Gly187Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.96952,1.0087546110153198,1.11565,0.4677786614725521,1.5425849999999999,1.218649330736276,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.1746,1.8092,-1.4464,-3.84952316833349,0.0508804604056052,Benign,0.6098,pathogenic,-3.574,available,https://doi.org/10.1101/2022.10.22.513328 +G187R,NP_000537:p.Gly187Arg,"hg19,17:g.7578371C>G, hg19,17:g.7675053C>G, hg38,17:g.7675053C>G",,,0.700,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",635392,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.92398,0.974842607975006,1.50748,-0.0504253534906506,1.71573,0.9367773232546747,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.2938,1.8092,-22.2419,-5.04099022305313,0.3075091274997505,Benign,0.6489,pathogenic,-3.662,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G187S,NP_000537:p.Gly187Ser,"hg19,17:g.7578371C>T, hg19,17:g.7675053C>T, hg38,17:g.7675053C>T",,,0.649,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",840399,Conflicting classifications of pathogenicity,1,,,Tier II - Potential,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.77959,0.8239881992340088,0.98776,0.4311903569354075,1.383675,1.1053901784677038,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.1359,1.8092,-5.1468,-2.60475214338246,0.0001467881703475,Benign,0.1262,benign,-3.23,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G187T,NP_000537:p.Gly187Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.10835,0.9121054410934448,1.50238,0.7726784617103035,1.805365,1.4405142308551517,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.2179,1.8092,-6.1468,-2.86096275188464,0.0101284754094703,Benign,0.2514,benign,-3.462,available,https://doi.org/10.1101/2022.10.22.513328 +G187V,NP_000537:p.Gly187Val,"hg19,17:g.7578289C>A, hg19,17:g.7674971C>A, hg38,17:g.7674971C>A, hg38,17:g.7674972del",,,0.666,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2032550,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.27538,1.101678729057312,5.41973,0.830133063296913,3.8475550000000003,1.5527565316484566,Uncertain,Uncertain,Uncertain,Destabilizing,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.2281,1.8092,-7.3692,-3.18355446101431,0.0138205652241666,Benign,0.3175,benign,-3.549,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G187W,NP_000537:p.Gly187Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.53222,0.8921064138412476,2.27925,-0.1760255663512006,1.905735,0.6780972168243997,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.3148,1.8092,-22.2419,-5.57393330133001,0.5533694911349891,Uncertain,0.6932,pathogenic,-4.192,available,https://doi.org/10.1101/2022.10.22.513328 +G187Y,NP_000537:p.Gly187Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.00381,0.9164707660675048,1.57517,0.1999414018492246,1.78949,1.1018757009246123,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.005,,,Uncertain,,Uncertain,,,Uncertain,110.4,,True,110.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,75.66,S,-0.3154,1.8092,-22.2419,-5.57393330133001,0.4024047053152033,Uncertain,0.6616,pathogenic,-3.899,available,https://doi.org/10.1101/2022.10.22.513328 +L188A,NP_000537:p.Leu188Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.75505,0.3989961147308349,2.12687,2.048301385284119,1.44096,1.4016756926420597,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,81.41,S,-0.0949,2.5085,-3.8667,-1.88041290835708,0.0001031998719289,Benign,0.2332,benign,-3.133,available,https://doi.org/10.1101/2022.10.22.513328 +L188C,NP_000537:p.Leu188Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.92372,0.1861359477043151,2.14558,2.4319077292025035,1.5346499999999998,1.6778138646012517,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,81.41,S,-0.1779,2.5085,-22.2419,-3.76520430130737,0.183021669992604,Benign,0.5863,pathogenic,-3.891,available,https://doi.org/10.1101/2022.10.22.513328 +L188D,NP_000537:p.Leu188Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.0415,0.9983850717544556,2.35204,3.026022430764687,1.6967700000000001,2.0337612153823432,Uncertain,Uncertain,Neutral,Neutral,Uncertain,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,81.41,S,-0.3102,2.5085,-22.2419,-3.88352603194585,0.1801055762532335,Benign,0.6577,pathogenic,-3.684,available,https://doi.org/10.1101/2022.10.22.513328 +L188E,NP_000537:p.Leu188Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.82489,0.8646618723869324,2.42585,2.790732346956468,1.62537,1.807811173478234,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,81.41,S,-0.2783,2.5085,-22.2419,-3.06959987779917,0.0155423694041354,Benign,0.4127,ambiguous,-3.47,available,https://doi.org/10.1101/2022.10.22.513328 +L188F,NP_000537:p.Leu188Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.63765,0.3927514553070068,0.61122,0.6878608165726119,0.6244350000000001,0.662755408286306,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,81.41,S,-0.0544,2.5085,-8.9541,-3.85313818661833,0.0025842669878029,Benign,0.2063,benign,-3.392,available,https://doi.org/10.1101/2022.10.22.513328 +L188G,NP_000537:p.Leu188Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.14235,0.666858971118927,3.32211,3.1253551560959947,2.23223,2.133852578047997,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,81.41,S,-0.1957,2.5085,-8.9541,-4.80408334732493,0.1419804086848305,Benign,0.5033,ambiguous,-3.542,available,https://doi.org/10.1101/2022.10.22.513328 +L188H,NP_000537:p.Leu188His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.41491,0.3075435161590576,1.43435,1.3373327328599598,1.42463,1.3761213664299798,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,81.41,S,-0.2311,2.5085,-22.2419,-3.35316717660366,0.0291104950210152,Benign,0.2979,benign,-3.45,available,https://doi.org/10.1101/2022.10.22.513328 +L188I,NP_000537:p.Leu188Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.7608,0.0422155857086181,0.95612,0.7430898678653636,0.85846,0.7519449339326818,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,81.41,S,0.0439,2.5085,-1.3321,-2.11522420262571,0.0120451884270478,Benign,0.1269,benign,-3.189,available,https://doi.org/10.1101/2022.10.22.513328 +L188K,NP_000537:p.Leu188Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28364,-0.1352220773696899,1.31701,2.1970483908967497,0.800325,1.240344195448375,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,81.41,S,-0.2095,2.5085,-8.9541,-3.64485453337967,0.0400993514253363,Benign,0.3779,ambiguous,-3.474,available,https://doi.org/10.1101/2022.10.22.513328 +L188M,NP_000537:p.Leu188Met,"hg38,17:g.7674969G>T",,,0.473,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.13688,0.1435773372650146,0.71327,1.1836521223918632,0.425075,0.6602660611959317,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,81.41,S,-0.004,2.5085,-6.1468,-2.03246337702532,0.0179310171339625,Benign,0.1544,benign,-3.266,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L188N,NP_000537:p.Leu188Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.84716,0.3566086292266845,1.80204,1.9455768350565323,1.3246,1.3963684175282662,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,81.41,S,-0.1836,2.5085,-7.9541,-2.69445479080042,0.0057044195774277,Benign,0.3632,ambiguous,-3.415,available,https://doi.org/10.1101/2022.10.22.513328 +L188P,NP_000537:p.Leu188Pro,"hg19,17:g.7578286A>G, hg38,17:g.7674968A>G",,,0.617,"ClinVar,saturation_mutlist",4189268,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.46639,1.0278264284133911,6.37075,4.858522631279529,4.41857,3.6624563156397647,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,81.41,S,-0.1839,2.5085,-4.9542,-2.07287529396529,9.920129325962272e-07,Benign,0.1339,benign,-3.047,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L188Q,NP_000537:p.Leu188Gln,"hg19,17:g.7578286A>T, hg38,17:g.7674968A>T",,,0.581,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.26448,0.2882698774337768,0.99218,2.158974107245543,0.6283299999999999,1.2117270536227713,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,81.41,S,-0.1204,2.5085,-4.7843,-4.02237159951265,0.1326427980461458,Benign,0.1893,benign,-3.521,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L188R,NP_000537:p.Leu188Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.45378,-0.1727283000946045,1.14762,1.4981655655769637,0.8007000000000001,0.9759727827884819,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,81.41,S,-0.193,2.5085,-7.3692,-2.17875171420542,0.0628984413568821,Benign,0.2609,benign,-3.514,available,https://doi.org/10.1101/2022.10.22.513328 +L188S,NP_000537:p.Leu188Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22054,0.4229460954666137,2.33946,2.5846066063090483,1.28,1.4025733031545242,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,81.41,S,-0.1228,2.5085,-3.3692,-1.80905429493487,6.01470442142463e-05,Benign,0.2905,benign,-3.173,available,https://doi.org/10.1101/2022.10.22.513328 +L188T,NP_000537:p.Leu188Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.81794,0.2515656948089599,1.79932,2.0352352526914275,1.30863,1.4265876263457138,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,81.41,S,-0.1122,2.5085,-6.6322,-1.91715341693648,0.0002229552270836,Benign,0.2467,benign,-3.167,available,https://doi.org/10.1101/2022.10.22.513328 +L188V,NP_000537:p.Leu188Val,"hg19,17:g.7578287G>C, hg38,17:g.7674969G>C",,,0.572,"COSMIC,ClinVar,saturation_mutlist",933702,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.08848,0.3278518915176391,1.6551,1.1196978210969055,1.3717899999999998,1.1040889105484526,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,81.41,S,-0.0053,2.5085,-3.8667,-1.55449930492216,6.715738354807394e-06,Benign,0.1186,benign,-3.056,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L188W,NP_000537:p.Leu188Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.88681,0.3504646420478821,1.68878,0.6581625330236653,1.287795,0.7724862665118326,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,81.41,S,-0.2213,2.5085,-22.2419,-4.37635006954498,0.5545923119647456,Uncertain,0.3995,ambiguous,-4.048,available,https://doi.org/10.1101/2022.10.22.513328 +L188Y,NP_000537:p.Leu188Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.69727,0.3275306820869446,0.46633,0.8724029763421228,0.5818,0.7848364881710614,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,,,Uncertain,,Uncertain,,,Uncertain,66.2,,True,66.2,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,81.41,S,-0.2142,2.5085,-22.2419,-4.0093896326611,0.0828497298309643,Benign,0.5037,ambiguous,-3.61,available,https://doi.org/10.1101/2022.10.22.513328 +A189C,NP_000537:p.Ala189Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.61957,0.2961156368255615,0.71156,0.4030207779679784,0.665565,0.5112953889839892,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.2711,0.7558,-22.2419,-3.86452100200476,0.7140128768112822,Pathogenic,0.7797,pathogenic,-3.894,available,https://doi.org/10.1101/2022.10.22.513328 +A189D,NP_000537:p.Ala189Asp,"hg19,17:g.7578283G>T, hg38,17:g.7674965G>T",,,0.817,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2137906,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.89617,1.5174694061279297,4.41429,0.7521027328450266,3.15523,1.3241363664225132,Uncertain,Neutral,Uncertain,Destabilizing,Neutral,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.2731,0.7558,-6.6322,-2.40147207040067,0.0034621877763093,Benign,0.9857,pathogenic,-3.492,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A189E,NP_000537:p.Ala189Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.78435,1.472724199295044,4.78401,0.4632390175833484,4.78418,2.6237945087916743,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.2451,0.7558,-3.9542,-3.04270652728897,0.0015664828591481,Benign,0.9731,pathogenic,-3.572,available,https://doi.org/10.1101/2022.10.22.513328 +A189F,NP_000537:p.Ala189Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.35866,0.9246112108230592,7.78129,-0.6749089384112367,8.569975,4.341875530794382,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.3212,0.7558,-22.2419,-4.92023944126789,0.2060104340334921,Benign,0.8472,pathogenic,-3.98,available,https://doi.org/10.1101/2022.10.22.513328 +A189G,NP_000537:p.Ala189Gly,"hg19,17:g.7578283G>C, hg38,17:g.7674965G>C",,,0.754,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1378428,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.27103,1.2739046812057495,2.21599,1.6701634148080995,1.2435100000000001,0.9705967074040498,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,90.73,S,-0.2646,0.7558,-22.2419,-5.8316505052007,0.3429367489301889,Uncertain,0.6979,pathogenic,-3.724,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A189H,NP_000537:p.Ala189His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.5749,0.792191743850708,2.66803,-0.1249385228232913,5.621465,4.224980738588354,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.3253,0.7558,-22.2419,-4.69013369362578,0.3720478102901257,Uncertain,0.956,pathogenic,-3.824,available,https://doi.org/10.1101/2022.10.22.513328 +A189I,NP_000537:p.Ala189Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.04692,1.0164488554000854,1.10646,-0.7107633296441962,2.07669,1.1680783351779018,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.2378,0.7558,-7.9541,-3.43688509217169,0.0904796685619637,Benign,0.798,pathogenic,-3.788,available,https://doi.org/10.1101/2022.10.22.513328 +A189K,NP_000537:p.Ala189Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.76778,1.0952363014221191,2.92891,0.3329229397900868,4.348345,3.0503514698950434,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.3431,0.7558,-22.2419,-6.004820990505,0.5242219220407693,Uncertain,0.9917,pathogenic,-3.926,available,https://doi.org/10.1101/2022.10.22.513328 +A189L,NP_000537:p.Ala189Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.43624,1.1768031120300293,1.47789,-0.6491863493427757,2.957065,1.893526825328612,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.3154,0.7558,-22.2419,-4.39216905711053,0.5244701268616785,Uncertain,0.6483,pathogenic,-3.801,available,https://doi.org/10.1101/2022.10.22.513328 +A189M,NP_000537:p.Ala189Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.54882,1.0845909118652344,0.71667,-0.278518139383232,1.6327450000000001,1.135150930308384,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.2064,0.7558,-8.9541,-4.65583039918258,0.5882663799147319,Uncertain,0.8523,pathogenic,-3.891,available,https://doi.org/10.1101/2022.10.22.513328 +A189N,NP_000537:p.Ala189Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.77054,1.0052571296691897,2.78844,0.3036246097316897,2.77949,1.5370823048658449,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.2554,0.7558,-8.9541,-3.17248839464023,0.0946032624124289,Benign,0.959,pathogenic,-3.687,available,https://doi.org/10.1101/2022.10.22.513328 +A189P,NP_000537:p.Ala189Pro,"hg19,17:g.7578284C>G, hg38,17:g.7674966C>G",,,0.721,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.39829,1.187954664230347,5.85748,2.791585584146002,3.127885,1.594937792073001,Uncertain,Uncertain,Uncertain,Destabilizing,Neutral,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.3925,0.7558,-22.2419,-3.86587816946943,0.1983686632226752,Benign,0.7205,pathogenic,-3.503,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A189Q,NP_000537:p.Ala189Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.74999,1.139063596725464,2.16905,0.3819056032922613,3.4595200000000004,2.565947801646131,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.3206,0.7558,-22.2419,-4.38722572508395,0.5910490022299049,Uncertain,0.9461,pathogenic,-3.81,available,https://doi.org/10.1101/2022.10.22.513328 +A189R,NP_000537:p.Ala189Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.50544,0.869221031665802,3.3119,-0.2241846172480111,3.90867,2.1406276913759945,Destabilizing,Uncertain,Neutral,Destabilizing,Uncertain,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.3538,0.7558,-22.2419,-5.78252468356624,0.7110451905600786,Pathogenic,0.9618,pathogenic,-4.011,available,https://doi.org/10.1101/2022.10.22.513328 +A189S,NP_000537:p.Ala189Ser,"hg19,17:g.7578284C>A, hg38,17:g.7674966C>A",,,0.700,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528262,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.25459,0.0821961164474487,1.50238,0.6913250750013455,0.878485,0.47295753750067276,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,90.73,S,-0.1578,0.7558,-6.9542,-2.63286801121178,0.0234409041587351,Benign,0.3994,ambiguous,-3.38,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A189T,NP_000537:p.Ala189Thr,"hg19,17:g.7578284C>T, hg38,17:g.7674966C>T",,,0.728,"COSMIC,ClinVar,saturation_mutlist",3972441,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35151,0.1291786432266235,1.6017,0.0240583833009672,0.976605,0.1877841916504836,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.1596,0.7558,-6.1468,-1.81167935946565,0.002830983688912,Benign,0.7003,pathogenic,-3.32,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A189V,NP_000537:p.Ala189Val,"hg19,17:g.7578283G>A, hg38,17:g.7674965G>A",,2.38617924979e-05,0.790,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12382,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.68612,0.160257339477539,2.17483,-0.6255001834328533,0.7443550000000001,-0.6558100917164267,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.1591,0.7558,-6.6322,-2.91132196336471,0.0009732444417626,Benign,0.5887,pathogenic,-3.382,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A189W,NP_000537:p.Ala189Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.26865,0.9221696853637696,12.77143,-0.983342113982298,10.52004,3.6426539430088507,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.3321,0.7558,-22.2419,-5.48234082674817,0.7889385000717355,Pathogenic,0.9773,pathogenic,-4.359,available,https://doi.org/10.1101/2022.10.22.513328 +A189Y,NP_000537:p.Ala189Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.8897,0.6921113729476929,9.64762,-0.5745864772728376,9.26866,4.157556761363581,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.007,,,,,,,,,4.1,,False,4.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,90.73,S,-0.3403,0.7558,-22.2419,-4.69421519135877,0.4909475052359561,Uncertain,0.932,pathogenic,-4.054,available,https://doi.org/10.1101/2022.10.22.513328 +P190A,NP_000537:p.Pro190Ala,"hg19,17:g.7578281G>C, hg38,17:g.7674963G>C",,,0.757,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1021934,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.88007,1.472026824951172,1.04694,0.0159939113791296,1.963505,1.4480319556895647,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.1984,0.6122,-7.9483,-2.99567003362681,0.0256344382178636,Benign,0.4869,ambiguous,-3.395,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190C,NP_000537:p.Pro190Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.52385,0.9853743314743042,1.80136,0.6625438949221352,2.662605,2.0931969474610677,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,92.74,-,-0.304,0.6122,-22.2361,-5.39324183254635,0.7982646144368102,Pathogenic,0.9435,pathogenic,-4.252,available,https://doi.org/10.1101/2022.10.22.513328 +P190D,NP_000537:p.Pro190Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.63876,1.1609551906585691,2.08673,-0.1325279643429827,2.3627450000000003,1.2531160178285086,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,92.74,-,-0.3299,0.6122,-22.2361,-5.69329186827132,0.5860607029495021,Uncertain,0.9678,pathogenic,-4.256,available,https://doi.org/10.1101/2022.10.22.513328 +P190E,NP_000537:p.Pro190Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.40436,1.7003662586212158,1.51531,-0.2848200260564193,1.959835,1.0597699869717903,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.3137,0.6122,-22.2361,-5.08079228164532,0.5154080921594626,Uncertain,0.9358,pathogenic,-3.988,available,https://doi.org/10.1101/2022.10.22.513328 +P190F,NP_000537:p.Pro190Phe,"hg38,17:g.7674962_7674963delinsAA",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.71204,1.605447769165039,0.78401,-0.3438657127429906,1.748025,1.1840871436285048,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.3324,0.6122,-22.2361,-4.64609065702091,0.1673133879220692,Benign,0.966,pathogenic,-4.01,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190G,NP_000537:p.Pro190Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.23737,2.0802102088928223,2.18844,0.8144952208104042,3.212905,2.525932610405202,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.2857,0.6122,-22.2361,-7.17116440263594,0.6999879865191387,Pathogenic,0.8994,pathogenic,-4.16,available,https://doi.org/10.1101/2022.10.22.513328 +P190H,NP_000537:p.Pro190His,"hg38,17:g.7674962G>T",,,0.731,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.20175,1.2425658702850342,1.34014,-0.5202111650556296,2.270945,1.3407694174721851,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.2151,0.6122,-3.6264,-3.24502230725534,0.000298703906099,Benign,0.7649,pathogenic,-3.575,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190I,NP_000537:p.Pro190Ile,"hg19,17:g.7578280_7578281delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.61693,1.775618553161621,1.7449,-4.205467897699933e-05,2.6809149999999997,1.8084439726605115,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.3155,0.6122,-22.2361,-5.72574202809181,0.6672094455933184,Uncertain,0.953,pathogenic,-4.004,available,https://doi.org/10.1101/2022.10.22.513328 +P190K,NP_000537:p.Pro190Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.80839,1.733384132385254,0.76156,-0.0032876070609327,1.7849750000000002,1.4025511964695336,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.3054,0.6122,-22.2361,-5.53443142894499,0.5577572913227822,Uncertain,0.9297,pathogenic,-3.996,available,https://doi.org/10.1101/2022.10.22.513328 +P190L,NP_000537:p.Pro190Leu,"hg19,17:g.7578280G>A, hg19,17:g.7674962G>A, hg38,17:g.7674962G>A",,,0.824,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",418517,Likely pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.52032,1.4754019975662231,0.38878,-0.4849872202959743,1.45455,1.0176663898520129,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.2523,0.6122,-8.9482,-5.71134636968457,0.1464515347828913,Benign,0.7083,pathogenic,-3.592,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190M,NP_000537:p.Pro190Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.26884,1.6811120510101318,0.99966,-0.1989190994187117,1.63425,1.0349604502906442,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.271,0.6122,-22.2361,-6.04764798472395,0.7422488729533716,Pathogenic,0.9414,pathogenic,-4.082,available,https://doi.org/10.1101/2022.10.22.513328 +P190N,NP_000537:p.Pro190Asn,"hg38,17:g.7674962_7674963delinsTT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.05318,1.1624152660369873,1.57721,-0.1220252066578214,2.315195,1.4655773966710892,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,92.74,-,-0.2222,0.6122,-7.3634,-3.83177689961355,0.0033214946249771,Benign,0.9398,pathogenic,-3.781,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190Q,NP_000537:p.Pro190Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.72729,1.67979896068573,0.9017,-0.0263020857984302,1.814495,1.3504939571007848,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.2319,0.6122,-8.9482,-4.57232831602291,0.178679502272349,Benign,0.8424,pathogenic,-3.762,available,https://doi.org/10.1101/2022.10.22.513328 +P190R,NP_000537:p.Pro190Arg,"hg19,17:g.7578280G>C, hg19,17:g.7674962G>C, hg38,17:g.7674962G>C",,,0.846,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",234061,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.91379,1.8559510707855225,1.04116,-0.1647432343463845,1.977475,1.3745233828268077,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.3412,0.6122,-22.2361,-5.59560735149418,0.2192902661998612,Benign,0.8268,pathogenic,-3.896,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190S,NP_000537:p.Pro190Ser,"hg19,17:g.7578281G>A, hg19,17:g.7674963G>A, hg38,17:g.7674963G>A",,,0.788,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",646725,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.36488,1.310901165008545,1.81769,0.0092582782303474,2.591285,1.6870691391151735,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.1981,0.6122,-7.9483,-3.5530655746616,0.0251230944650167,Benign,0.6927,pathogenic,-3.55,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190T,NP_000537:p.Pro190Thr,"hg19,17:g.7578281G>T, hg19,17:g.7674963G>T, hg38,17:g.7674963G>T",,,0.822,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",233197,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.20085,1.758466362953186,1.97721,0.1700154816349997,3.08903,2.1854327408175,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,92.74,-,-0.2832,0.6122,-22.2361,-5.26746995626814,0.0759742996170473,Benign,0.8083,pathogenic,-4.005,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P190V,NP_000537:p.Pro190Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.36476,1.8411650657653809,1.3034,0.1155637952373317,2.33408,1.740161897618666,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.2709,0.6122,-22.2361,-5.61288001436523,0.4415117329516,Uncertain,0.8915,pathogenic,-3.816,available,https://doi.org/10.1101/2022.10.22.513328 +P190W,NP_000537:p.Pro190Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.76277,1.645049214363098,1.35034,-0.7876012538680682,2.0565550000000004,0.9875843730659659,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.345,0.6122,-22.2361,-5.29985898511672,0.8521025564993261,Pathogenic,0.9834,pathogenic,-4.59,available,https://doi.org/10.1101/2022.10.22.513328 +P190Y,NP_000537:p.Pro190Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.80718,1.42944073677063,0.70918,-0.4200079474217155,1.7581799999999999,1.1935860262891422,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,33.2,,False,33.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.74,-,-0.2605,0.6122,-7.9483,-3.50805252659365,0.0454933653739958,Benign,0.9581,pathogenic,-3.962,available,https://doi.org/10.1101/2022.10.22.513328 +P191A,NP_000537:p.Pro191Ala,"hg38,17:g.7674960G>C",,,0.598,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.89183,0.2263100743293762,0.52959,0.2582913534108527,1.21071,1.0750606767054263,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.105,1.3131,-2.2759,-1.57010272545414,3.446713775396139e-07,Benign,0.1423,benign,-3.14,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P191C,NP_000537:p.Pro191Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.4799,0.2428122758865356,1.25068,0.9352048360030708,1.8652900000000001,1.7075524180015356,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.45,T,-0.2395,1.3131,-22.2361,-3.53127984662828,0.2023007847588735,Benign,0.8088,pathogenic,-4.004,available,https://doi.org/10.1101/2022.10.22.513328 +P191D,NP_000537:p.Pro191Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.61232,0.7945495843887329,1.86054,0.4509324886303939,2.23643,1.531626244315197,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.45,T,-0.2654,1.3131,-22.2361,-4.88970838450263,0.5556604817528131,Uncertain,0.945,pathogenic,-4.104,available,https://doi.org/10.1101/2022.10.22.513328 +P191E,NP_000537:p.Pro191Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.04987,0.5739598870277405,1.59898,0.2439154574366114,1.3244250000000002,0.6468927287183057,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.2492,1.3131,-22.2361,-4.79966390505317,0.2481910502566461,Benign,0.8377,pathogenic,-4.086,available,https://doi.org/10.1101/2022.10.22.513328 +P191F,NP_000537:p.Pro191Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.91309,0.7950834631919861,1.01565,-0.1802011261835312,1.46437,0.8664444369082344,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.268,1.3131,-22.2361,-5.36434554185942,0.8001188617172952,Pathogenic,0.9425,pathogenic,-4.293,available,https://doi.org/10.1101/2022.10.22.513328 +P191G,NP_000537:p.Pro191Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.61474,0.619768500328064,1.50374,1.232677130095537,2.05924,1.9237085650477685,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.2212,1.3131,-22.2361,-4.6525734700151,0.1876182964457253,Benign,0.6704,pathogenic,-3.928,available,https://doi.org/10.1101/2022.10.22.513328 +P191H,NP_000537:p.Pro191His,"hg19,17:g.7578277G>T, hg38,17:g.7674959G>T",,3.9765226105e-06,0.797,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",853530,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.72137,0.3664963841438293,1.33571,0.0460709403559733,2.02854,1.3837204701779866,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.2456,1.3131,-22.2361,-5.0015821412385,0.2613204073418738,Benign,0.6467,pathogenic,-3.944,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P191I,NP_000537:p.Pro191Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.9265,0.7887586951255798,1.72483,-0.1913648532668466,1.825665,0.8675675733665767,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.251,1.3131,-22.2361,-4.38680537016079,0.2245637859921811,Benign,0.8878,pathogenic,-4.01,available,https://doi.org/10.1101/2022.10.22.513328 +P191K,NP_000537:p.Pro191Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.52549,0.2776988744735718,0.77653,0.1713851091418117,1.15101,0.8484375545709059,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.1629,1.3131,-6.9483,-2.88333205684934,0.0103107752436759,Benign,0.7883,pathogenic,-3.838,available,https://doi.org/10.1101/2022.10.22.513328 +P191L,NP_000537:p.Pro191Leu,"hg19,17:g.7578277G>A, hg19,17:g.7674959G>A, hg38,17:g.7674959G>A",,3.9765226105e-06,0.748,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2703874,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.70207,0.6375683546066284,0.69558,-0.3659297230593639,1.198825,0.668070138470318,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.2556,1.3131,-22.2361,-4.30289476148818,0.1725939363228339,Benign,0.5851,pathogenic,-3.809,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P191M,NP_000537:p.Pro191Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.94853,0.6447290182113647,1.55136,-0.078310633648308,1.749945,0.9351096831758461,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.2065,1.3131,-22.2361,-4.60463896300342,0.4343262898123536,Uncertain,0.8586,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328 +P191N,NP_000537:p.Pro191Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.30556,0.3937069773674011,1.05476,0.3536009612820057,1.6801599999999999,1.3295804806410028,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.45,T,-0.2336,1.3131,-22.2361,-4.37829278852242,0.222625439275989,Benign,0.8511,pathogenic,-3.953,available,https://doi.org/10.1101/2022.10.22.513328 +P191Q,NP_000537:p.Pro191Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.73567,0.3783401250839233,1.35374,0.3537599171219457,1.544705,1.044714958560973,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.2353,1.3131,-22.2361,-4.99633471671181,0.0775838803730872,Benign,0.5141,ambiguous,-3.828,available,https://doi.org/10.1101/2022.10.22.513328 +P191R,NP_000537:p.Pro191Arg,"hg19,17:g.7578277G>C, hg38,17:g.7674959G>C",,1.19295678315e-05,0.617,"COSMIC,ClinVar,saturation_mutlist",127816,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.12218,0.4081454277038574,0.95306,-0.2464633651499947,1.03762,0.43785831742500264,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.1802,1.3131,-3.3337,-2.35161070148448,6.022513884568006e-06,Benign,0.5246,ambiguous,-3.579,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P191S,NP_000537:p.Pro191Ser,"hg19,17:g.7578278G>A, hg38,17:g.7674960G>A",,,0.722,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1024017,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.58372,0.1892153024673462,0.64354,0.3974235425301653,1.6136300000000001,1.4905717712650826,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.1285,1.3131,-6.9483,-1.80852078612712,0.0055084348798353,Benign,0.3445,ambiguous,-3.499,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P191T,NP_000537:p.Pro191Thr,"hg38,17:g.7674960G>T",,,0.727,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.96192,0.4323943257331848,0.63605,0.206460697551763,1.798985,1.5841903487758815,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.45,T,-0.2187,1.3131,-22.2361,-3.21332629010937,0.1440979354551821,Benign,0.5102,ambiguous,-3.75,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P191V,NP_000537:p.Pro191Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.24998,0.7105965614318848,0.9119,-0.1380014554936842,1.58094,1.0559892722531579,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.1386,1.3131,-8.9482,-3.95358254067611,0.0371820931343541,Benign,0.7007,pathogenic,-3.774,available,https://doi.org/10.1101/2022.10.22.513328 +P191W,NP_000537:p.Pro191Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.52993,0.8444065451622009,0.94762,-0.6313636940507239,1.738775,0.949283152974638,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.2805,1.3131,-22.2361,-5.546325080267,0.8025260948811298,Pathogenic,0.9586,pathogenic,-4.48,available,https://doi.org/10.1101/2022.10.22.513328 +P191Y,NP_000537:p.Pro191Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.26916,0.6554126143455505,0.9068,-0.177523604538104,1.58798,1.045818197730948,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.011,,,Uncertain,,Uncertain,,,Uncertain,48.8,,False,48.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.45,T,-0.2689,1.3131,-22.2361,-5.546325080267,0.7527720311309269,Pathogenic,0.9189,pathogenic,-4.373,available,https://doi.org/10.1101/2022.10.22.513328 +Q192A,NP_000537:p.Gln192Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.96547,0.3472834825515747,0.03231,0.2559855506861236,0.49889,0.6107277753430618,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.02248,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,93.42,T,-0.082,1.4461,-5.6264,-1.21954171838872,0.0020181554319966,Benign,0.2354,benign,-3.395,available,https://doi.org/10.1101/2022.10.22.513328 +Q192C,NP_000537:p.Gln192Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.21676,-0.0168354511260986,0.88095,0.6682298840256357,1.048855,0.9424949420128179,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.01854,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,93.42,T,-0.213,1.4461,-22.2361,-1.80142958859435,0.2424503298952133,Benign,0.7827,pathogenic,-3.72,available,https://doi.org/10.1101/2022.10.22.513328 +Q192D,NP_000537:p.Gln192Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.79785,0.4198439121246338,2.0585,0.3893070288867872,1.928175,1.0935785144433936,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.015,0.20452,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,93.42,T,-0.1737,1.4461,-6.6264,-2.21723682565024,0.0012593948276139,Benign,0.5891,pathogenic,-3.38,available,https://doi.org/10.1101/2022.10.22.513328 +Q192E,NP_000537:p.Gln192Glu,"hg19,17:g.7578275G>C, hg38,17:g.7674957G>C",,,0.557,"ClinVar,saturation_mutlist",2679236,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.87978,0.2492132782936096,1.22789,0.2491898200184866,1.0538349999999999,0.5644849100092433,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.09688,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,93.42,T,-0.0898,1.4461,-6.141,-1.16249853220175,0.0007421921406419,Benign,0.1097,benign,-3.264,available,https://doi.org/10.1101/2022.10.22.513328 +Q192F,NP_000537:p.Gln192Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.0708,0.1915053725242614,0.20714,-0.5157508230443697,0.63897,0.27752458847781514,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.04976,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.42,T,-0.221,1.4461,-22.2361,-5.1254221930891,0.3981216306880295,Uncertain,0.8753,pathogenic,-4.05,available,https://doi.org/10.1101/2022.10.22.513328 +Q192G,NP_000537:p.Gln192Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.32963,0.398062527179718,1.03503,1.1263568272068123,1.1823299999999999,1.2279934136034063,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.02404,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,93.42,T,-0.1492,1.4461,-4.9484,-2.51864708332323,2.804078525566736e-05,Benign,0.261,benign,-3.271,available,https://doi.org/10.1101/2022.10.22.513328 +Q192H,NP_000537:p.Gln192His,"hg19,17:g.7578273C>A, hg19,17:g.7578273C>G, hg19,17:g.7674955C>A, hg38,17:g.7674955C>A, hg38,17:g.7674955C>G",,,"0.534, 0.537","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","988617, 922531","Likely benign, Uncertain significance","1, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.49267,-0.3905314207077026,0.13231,-0.2754659137054649,0.8124899999999999,0.6086020431472675,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.0104,0.2522,Neutral,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.42,T,-0.0899,1.4461,-6.9483,-1.73335343456233,0.0084400897537684,Benign,0.3598,ambiguous,-3.366,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q192I,NP_000537:p.Gln192Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.5507,0.7440402507781982,0.32857,-0.384814428561222,0.439635,0.08294278571938898,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.00416,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.42,T,-0.2024,1.4461,-22.2361,-5.24208629151928,0.4362013442337831,Uncertain,0.7849,pathogenic,-4.172,available,https://doi.org/10.1101/2022.10.22.513328 +Q192K,NP_000537:p.Gln192Lys,"hg38,17:g.7674957G>T",,,0.640,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.41574,0.2073543071746826,-0.01837,0.0850744580864015,0.198685,0.25040722904320073,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.08762,-0.14474,Neutral,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.42,T,-0.2,1.4461,-22.2361,-3.90293857336837,0.1038913167874694,Benign,0.2843,benign,-3.626,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q192L,NP_000537:p.Gln192Leu,"hg19,17:g.7578274T>A, hg38,17:g.7674956T>A",,,0.718,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.93186,0.6709622144699097,0.14286,-0.594824596434082,0.5373600000000001,0.168517701782959,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.00496,0.34324,Neutral,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.42,T,-0.1857,1.4461,-22.2361,-4.30901436282833,0.2076676840873783,Benign,0.3186,benign,-3.672,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q192M,NP_000537:p.Gln192Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.36939,0.5421051979064941,0.44218,-0.2768999967765945,0.405785,0.04624500161170275,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.02218,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.42,T,-0.1567,1.4461,-22.2361,-4.87898623365176,0.1590701352797799,Benign,0.5933,pathogenic,-3.78,available,https://doi.org/10.1101/2022.10.22.513328 +Q192N,NP_000537:p.Gln192Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.24745,0.135178804397583,1.14694,0.070009446788769,1.197195,0.6587297233943845,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.0152,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,93.42,T,-0.1095,1.4461,-7.9483,-2.00161405568868,0.0004740024170053,Benign,0.3832,ambiguous,-3.424,available,https://doi.org/10.1101/2022.10.22.513328 +Q192P,NP_000537:p.Gln192Pro,"hg19,17:g.7578274T>G, hg38,17:g.7674956T>G",,,0.769,"ClinVar,saturation_mutlist",1036209,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.43128,0.9046283960342408,3.35374,2.768601698737986,1.46123,1.168660849368993,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.015,-0.02324,0.08481,Neutral,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,93.42,T,-0.3404,1.4461,-22.2361,-5.41081355098746,0.1406338125413811,Benign,0.3204,benign,-3.549,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q192R,NP_000537:p.Gln192Arg,"hg19,17:g.7578274T>C, hg19,17:g.7674956T>C, hg38,17:g.7674956T>C",,,0.677,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182931,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.97226,0.2153940796852111,0.65068,-0.4198727624727399,0.81147,0.27619361876363,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.17558,0.07085,Neutral,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.42,T,-0.1188,1.4461,-6.6264,-2.49721471871481,0.0020839843485994,Benign,0.2727,benign,-3.46,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Q192S,NP_000537:p.Gln192Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48944,0.2276724576950073,0.42755,0.3099320647821879,0.458495,0.3996860323910939,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,-0.01774,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,93.42,T,-0.0745,1.4461,-0.539,-1.25501259388064,3.394137530607636e-06,Benign,0.2403,benign,-3.092,available,https://doi.org/10.1101/2022.10.22.513328 +Q192T,NP_000537:p.Gln192Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.79322,0.2067484855651855,-0.49116,0.1355342627399286,0.65103,0.9643771313699643,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.00798,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,93.42,T,-0.1951,1.4461,-22.2361,-2.58105989531754,0.0457492482205241,Benign,0.3754,ambiguous,-3.552,available,https://doi.org/10.1101/2022.10.22.513328 +Q192V,NP_000537:p.Gln192Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.22086,0.6342512369155884,-0.44456,-0.167108510447464,0.38815,0.526875744776268,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.00194,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.42,T,-0.2025,1.4461,-22.2361,-4.57586104055003,0.2636363463082882,Benign,0.5828,pathogenic,-3.854,available,https://doi.org/10.1101/2022.10.22.513328 +Q192W,NP_000537:p.Gln192Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.07749,0.2297320365905761,-0.80952,-0.9532224980654042,0.633985,0.5621337509672979,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.015,0.0103,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.42,T,-0.2204,1.4461,-22.2361,-5.1254221930891,0.7627597111538336,Pathogenic,0.8096,pathogenic,-4.266,available,https://doi.org/10.1101/2022.10.22.513328 +Q192Y,NP_000537:p.Gln192Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.12235,-0.1322443485260009,1.11871,-0.534045655945119,1.12053,0.2941521720274405,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.015,0.04152,,Uncertain,,Uncertain,,,Uncertain,30.3,,False,30.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.42,T,-0.1555,1.4461,-8.9482,-4.80763491374168,0.2022236172012396,Benign,0.7393,pathogenic,-3.798,available,https://doi.org/10.1101/2022.10.22.513328 +H193A,NP_000537:p.His193Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.55987,0.7523599863052368,0.82381,1.854315243421801,0.69184,1.2070926217109006,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.2971,0.0001,-22.2419,-8.25135518731248,0.8650119547224437,Pathogenic,0.9991,pathogenic,-4.536,available,https://doi.org/10.1101/2022.10.22.513328 +H193C,NP_000537:p.His193Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.25955,0.2654207944869995,0.82653,1.6249304956115032,0.54304,0.9422402478057516,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.3516,0.0001,-22.2419,-8.25135518731248,0.8691055971581964,Pathogenic,0.9677,pathogenic,-4.493,available,https://doi.org/10.1101/2022.10.22.513328 +H193D,NP_000537:p.His193Asp,"hg19,17:g.7578272G>C, hg19,17:g.7674954G>C, hg38,17:g.7674954G>C",,,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376613,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.34909,1.7393343448638916,2.27789,2.337752259809405,1.81349,1.8434211299047025,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.3443,0.0001,-22.2419,-7.14475957649214,0.8408680176603252,Pathogenic,0.998,pathogenic,-4.574,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H193E,NP_000537:p.His193Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.59563,1.7385225296020508,1.70952,2.18730274178668,1.6525750000000001,1.89146637089334,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.3558,0.0001,-22.2419,-7.14475957649214,0.8513434746720763,Pathogenic,0.9989,pathogenic,-4.636,available,https://doi.org/10.1101/2022.10.22.513328 +H193F,NP_000537:p.His193Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-2.9438,-0.1706224679946899,-1.71939,-0.976430329831796,-2.331595,-1.9601151649158979,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.3187,0.0001,-22.2419,-4.26416354098304,0.7265980662693861,Pathogenic,0.983,pathogenic,-4.249,available,https://doi.org/10.1101/2022.10.22.513328 +H193G,NP_000537:p.His193Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.25099,1.8183083534240725,2.73912,3.2803392565802323,2.495055,2.765664628290116,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.3796,0.0001,-22.2419,-8.25135518731248,0.8543686720263909,Pathogenic,0.999,pathogenic,-4.653,available,https://doi.org/10.1101/2022.10.22.513328 +H193I,NP_000537:p.His193Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.84321,0.6523203253746033,-1.10782,0.3444414229175596,-1.4755150000000001,-0.7493842885412202,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.3833,0.0001,-22.2419,-8.25135518731248,0.8621369096099027,Pathogenic,0.9993,pathogenic,-4.706,available,https://doi.org/10.1101/2022.10.22.513328 +H193K,NP_000537:p.His193Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.5652,1.3397518396377563,2.29218,1.9304439364658803,1.92869,1.7478219682329401,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.34,0.0001,-22.2419,-7.00779851000983,0.8515214979902532,Pathogenic,0.9992,pathogenic,-4.515,available,https://doi.org/10.1101/2022.10.22.513328 +H193L,NP_000537:p.His193Leu,"hg19,17:g.7578271T>A, hg19,17:g.7674953T>A, hg38,17:g.7674953T>A",,,0.864,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",185822,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.1384,0.8584891557693481,0.09252,-0.0726198477659756,-0.5229400000000001,-0.6055099238829879,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.3469,0.0001,-22.2419,-8.25135518731248,0.8290371042772586,Pathogenic,0.9942,pathogenic,-4.525,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H193M,NP_000537:p.His193Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.37713,0.8412086963653564,-1.01361,0.3391626732267411,-1.19537,-0.5189836633866294,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.297,0.0001,-22.2419,-8.25135518731248,0.8296537410534872,Pathogenic,0.9981,pathogenic,-4.667,available,https://doi.org/10.1101/2022.10.22.513328 +H193N,NP_000537:p.His193Asn,"hg19,17:g.7578272G>T, hg19,17:g.7578272_7578273delinsTT, hg19,17:g.7674954G>T, hg38,17:g.7674954G>T",,,0.875,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3460301,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.82174,0.9232580661773682,1.81701,1.197550449497209,1.319375,1.0096452247486045,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.3038,0.0001,-22.2419,-7.14475957649214,0.8683567446247316,Pathogenic,0.9845,pathogenic,-4.157,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H193P,NP_000537:p.His193Pro,"hg19,17:g.7578271T>G, hg19,17:g.7674953T>G, hg38,17:g.7674953T>G",,,0.870,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376612,Pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.5858,1.7195320129394531,7.4068,5.774857279537604,4.9963,4.180328639768802,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.4603,0.0001,-22.2419,-8.25135518731248,0.851502670906509,Pathogenic,0.9975,pathogenic,-4.494,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H193Q,NP_000537:p.His193Gln,"hg19,17:g.7578270A>C, hg19,17:g.7578270A>T, hg38,17:g.7674952A>T",,,0.807,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",825975,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.19117,1.259917974472046,0.74116,1.3773031027367555,0.966165,1.2842365513683778,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.2653,0.0001,-22.2419,-6.22965436600818,0.6323469453321534,Uncertain,0.9979,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H193R,NP_000537:p.His193Arg,"hg19,17:g.7578270_7578271delinsGC, hg19,17:g.7578271T>C, hg19,17:g.7674953T>C, hg38,17:g.7674953T>C",,,0.884,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",184979,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,3.85949,1.086165189743042,2.56395,1.1688875590596062,3.21172,2.5141887795298032,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.3334,0.0001,-22.2419,-5.99226010418964,0.8704227796314765,Pathogenic,0.9982,pathogenic,-4.324,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H193S,NP_000537:p.His193Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.02456,0.8932664394378662,2.11429,2.1763541422213204,1.5694249999999998,1.60045707111066,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.303,0.0001,-22.2419,-8.25135518731248,0.8254849465109046,Pathogenic,0.9971,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328 +H193T,NP_000537:p.His193Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.40109,0.8151617050170898,0.88095,1.6325268025214512,0.64102,1.0168084012607257,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.3479,0.0001,-22.2419,-8.25135518731248,0.8600364586907797,Pathogenic,0.9995,pathogenic,-4.547,available,https://doi.org/10.1101/2022.10.22.513328 +H193V,NP_000537:p.His193Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.92652,0.2780985832214355,-1.07619,0.5645323450274089,-1.001355,-0.18099382748629556,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.3397,0.0001,-22.2419,-8.25135518731248,0.8691793509928001,Pathogenic,0.9992,pathogenic,-4.628,available,https://doi.org/10.1101/2022.10.22.513328 +H193W,NP_000537:p.His193Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.82948,0.0552577972412109,0.85068,-0.7119176729125215,4.34008,3.558781163543739,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.3349,0.0001,-22.2419,-4.9521636373717,0.8700682950850218,Pathogenic,0.9784,pathogenic,-4.694,available,https://doi.org/10.1101/2022.10.22.513328 +H193Y,NP_000537:p.His193Tyr,"hg19,17:g.7578272G>A, hg19,17:g.7674954G>A, hg38,17:g.7674954G>A",,,0.887,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",230256,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28682,-0.4618656635284424,-0.74184,-0.6032064985606739,-0.22751000000000002,-0.15819324928033693,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.057,,,,,,,,,1.7,,False,1.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.71,-,-0.2689,0.0001,-22.2419,-4.01303053158416,0.5690906030896246,Uncertain,0.9627,pathogenic,-4.114,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194A,NP_000537:p.Leu194Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.38984,1.9004312753677368,3.41633,3.050807555772431,3.403085,3.2203237778862155,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,97.01,S,-0.4176,0.021,-22.2419,-8.07358961589327,0.8583214048818935,Pathogenic,0.9926,pathogenic,-4.555,available,https://doi.org/10.1101/2022.10.22.513328 +L194C,NP_000537:p.Leu194Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.41917,1.2682411670684814,2.88265,3.0959347176247047,3.1509099999999997,3.2575523588123523,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,97.01,S,-0.4068,0.021,-22.2419,-8.07358961589327,0.8687044177666676,Pathogenic,0.9933,pathogenic,-4.5,available,https://doi.org/10.1101/2022.10.22.513328 +L194D,NP_000537:p.Leu194Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.25903,2.3739702701568604,4.30068,4.341891094644708,4.2798549999999995,4.300460547322354,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,97.01,S,-0.5391,0.021,-22.2419,-8.07358961589327,0.8707121580009813,Pathogenic,0.9998,pathogenic,-4.789,available,https://doi.org/10.1101/2022.10.22.513328 +L194E,NP_000537:p.Leu194Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.69181,2.3111112117767334,3.63333,3.9029559019681694,3.6625699999999997,3.7973829509840846,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,97.01,S,-0.5072,0.021,-22.2419,-8.07358961589327,0.8690438677445209,Pathogenic,0.9993,pathogenic,-4.685,available,https://doi.org/10.1101/2022.10.22.513328 +L194F,NP_000537:p.Leu194Phe,"hg19,17:g.7578269G>A, hg19,17:g.7674951G>A, hg38,17:g.7674951G>A",,,0.851,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127817,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.88237,1.2148520946502686,0.52075,0.7423177552664456,1.70156,1.8123438776332228,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,97.01,S,-0.2832,0.021,-8.9541,-5.28126106416149,0.0324725884338868,Benign,0.9428,pathogenic,-3.615,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194G,NP_000537:p.Leu194Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.79424,2.457645893096924,4.82585,5.156736046699348,4.810045000000001,4.9754880233496745,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,97.01,S,-0.4924,0.021,-22.2419,-8.07358961589327,0.8685993851998238,Pathogenic,0.9986,pathogenic,-4.724,available,https://doi.org/10.1101/2022.10.22.513328 +L194H,NP_000537:p.Leu194His,"hg19,17:g.7578268A>T, hg19,17:g.7674950A>T, hg38,17:g.7674950A>T",,,0.918,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376634,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.13918,2.376237869262696,2.01871,2.300440058553925,2.578945,2.7198100292769625,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,97.01,S,-0.46,0.021,-22.2419,-6.32813408679831,0.8707985517890111,Pathogenic,0.9974,pathogenic,-4.47,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194I,NP_000537:p.Leu194Ile,"hg19,17:g.7578269G>T, hg38,17:g.7674951G>T",,,0.791,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28381,0.6213680505752563,1.49082,0.991568681936036,0.8873150000000001,0.637689340968018,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,97.01,S,-0.2917,0.021,-22.2419,-3.75098857645665,0.3824737590859234,Uncertain,0.5835,pathogenic,-3.668,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194K,NP_000537:p.Leu194Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.94123,2.5354459285736084,5.18061,4.336416665759251,5.560919999999999,5.138823332879626,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,97.01,S,-0.5062,0.021,-22.2419,-8.07358961589327,0.8630146072540739,Pathogenic,0.9978,pathogenic,-4.64,available,https://doi.org/10.1101/2022.10.22.513328 +L194M,NP_000537:p.Leu194Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.10165,0.9792985916137696,1.27313,1.4561993711687298,0.6873900000000001,0.7789246855843649,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,97.01,S,-0.315,0.021,-22.2419,-3.95420430738313,0.8500422283408849,Pathogenic,0.8253,pathogenic,-4.008,available,https://doi.org/10.1101/2022.10.22.513328 +L194N,NP_000537:p.Leu194Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.19806,2.433952569961548,3.23299,3.1390857511203163,3.715525,3.668572875560158,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,97.01,S,-0.4854,0.021,-22.2419,-8.07358961589327,0.8700870557873067,Pathogenic,0.9987,pathogenic,-4.65,available,https://doi.org/10.1101/2022.10.22.513328 +L194P,NP_000537:p.Leu194Pro,"hg19,17:g.7578268A>G, hg19,17:g.7674950A>G, hg38,17:g.7674950A>G",,,0.937,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376635,Uncertain significance,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.68505,2.0482027530670166,2.51259,5.5249730638769785,2.09882,3.605011531938489,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,97.01,S,-0.501,0.021,-22.2419,-8.07358961589327,0.8452217603580727,Pathogenic,0.9989,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194Q,NP_000537:p.Leu194Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.45213,2.388613224029541,2.45816,2.882685476992136,2.955145,3.1674077384960677,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,97.01,S,-0.4384,0.021,-22.2419,-8.07358961589327,0.8661059872690757,Pathogenic,0.9979,pathogenic,-4.415,available,https://doi.org/10.1101/2022.10.22.513328 +L194R,NP_000537:p.Leu194Arg,"hg19,17:g.7578268A>C, hg19,17:g.7674950A>C, hg38,17:g.7674950A>C",,3.9763644895e-06,0.933,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376633,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.90144,2.668038845062256,5.28401,3.5122086444320804,7.592725,6.70682432221604,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,97.01,S,-0.4978,0.021,-22.2419,-8.07358961589327,0.8708434893456363,Pathogenic,0.9952,pathogenic,-4.526,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194S,NP_000537:p.Leu194Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.67487,2.354665756225586,4.37653,4.021018910848319,4.5257000000000005,4.34794445542416,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,97.01,S,-0.448,0.021,-22.2419,-8.07358961589327,0.8706631324317787,Pathogenic,0.9988,pathogenic,-4.459,available,https://doi.org/10.1101/2022.10.22.513328 +L194T,NP_000537:p.Leu194Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.58657,2.094610452651977,2.37381,2.713972345141769,2.9801900000000003,3.1502711725708847,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,97.01,S,-0.4207,0.021,-22.2419,-8.07358961589327,0.8597017778433296,Pathogenic,0.9936,pathogenic,-4.477,available,https://doi.org/10.1101/2022.10.22.513328 +L194V,NP_000537:p.Leu194Val,"hg19,17:g.7578269G>C, hg38,17:g.7674951G>C",,,0.833,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.65588,0.801816463470459,0.94014,1.13131557142301,1.29801,1.393597785711505,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,DOWN,stabilizing,damaging,False,neutral,neutral,97.01,S,-0.328,0.021,-22.2419,-4.06512820151916,0.1112249142806883,Benign,0.7109,pathogenic,-3.694,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L194W,NP_000537:p.Leu194Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.6083,1.8193267583847048,0.85952,1.955142478002924,3.73391,4.281721239001462,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,97.01,S,-0.4502,0.021,-22.2419,-5.78917545840285,0.4702581870887263,Uncertain,0.9939,pathogenic,-4.234,available,https://doi.org/10.1101/2022.10.22.513328 +L194Y,NP_000537:p.Leu194Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.42849,1.860575079917908,1.21973,1.69390437870007,2.82411,3.061197189350035,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,False,0.198,,,,,,,,,1.9,,False,1.9,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,97.01,S,-0.4431,0.021,-22.2419,-6.32813408679831,0.867127404636066,Pathogenic,0.996,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328 +I195A,NP_000537:p.Ile195Ala,"hg19,17:g.7578265_7578266delinsGC",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.15143,2.6812520027160645,3.61327,3.095096966716703,3.88235,3.6232634833583517,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.65,E,-0.4013,0.2723,-22.2419,-6.41975022589998,0.8708148865193323,Pathogenic,0.9945,pathogenic,-4.256,available,https://doi.org/10.1101/2022.10.22.513328 +I195C,NP_000537:p.Ile195Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.33907,1.933224439620972,3.07143,3.06338220566964,3.20525,3.20122610283482,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.65,E,-0.3812,0.2723,-22.2419,-5.40924899061051,0.8627193598446419,Pathogenic,0.9942,pathogenic,-4.24,available,https://doi.org/10.1101/2022.10.22.513328 +I195D,NP_000537:p.Ile195Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.62331,3.9241342544555664,4.48401,4.281748970403032,4.55366,4.4525294852015165,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.65,E,-0.5253,0.2723,-22.2419,-7.4631744305005,0.870846191076935,Pathogenic,0.9999,pathogenic,-4.552,available,https://doi.org/10.1101/2022.10.22.513328 +I195E,NP_000537:p.Ile195Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.21238,3.7718818187713614,3.34456,3.6842087944736543,3.7784699999999996,3.948294397236827,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.65,E,-0.5062,0.2723,-22.2419,-7.4631744305005,0.8683509906837552,Pathogenic,0.9993,pathogenic,-4.527,available,https://doi.org/10.1101/2022.10.22.513328 +I195F,NP_000537:p.Ile195Phe,"hg19,17:g.7578266T>A, hg19,17:g.7674948T>A, hg38,17:g.7674948T>A",,,0.904,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376617,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.32976,1.9790326356887813,3.03878,1.478604949599462,4.68427,3.904182474799731,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.65,E,-0.3622,0.2723,-22.2419,-6.96272216613622,0.6398104291326352,Uncertain,0.9288,pathogenic,-4.077,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195G,NP_000537:p.Ile195Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.64875,3.547344923019409,5.5619,5.31368974163512,5.605325,5.48121987081756,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.65,E,-0.4919,0.2723,-22.2419,-7.4631744305005,0.8708474002638746,Pathogenic,0.999,pathogenic,-4.52,available,https://doi.org/10.1101/2022.10.22.513328 +I195H,NP_000537:p.Ile195His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.67296,3.4920783042907715,3.57619,2.6421992351323014,4.624575,4.15757961756615,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.65,E,-0.4918,0.2723,-22.2419,-6.96272216613622,0.8580669810492387,Pathogenic,0.9992,pathogenic,-4.382,available,https://doi.org/10.1101/2022.10.22.513328 +I195K,NP_000537:p.Ile195Lys,"hg19,17:g.7578264_7578265delinsTT, hg38,17:g.7674946_7674947delinsTT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.66906,3.25440526008606,5.06633,4.527148244155692,4.867694999999999,4.598104122077846,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.65,E,-0.4987,0.2723,-22.2419,-7.4631744305005,0.8636284613371448,Pathogenic,0.9982,pathogenic,-4.424,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195L,NP_000537:p.Ile195Leu,"hg38,17:g.7674948T>G",,,0.724,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35754,0.980891227722168,0.72381,0.6074098734520478,0.540675,0.48247493672602393,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.65,E,-0.2025,0.2723,-5.7843,-2.06454558168875,0.0189015191667626,Benign,0.2338,benign,-3.298,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195M,NP_000537:p.Ile195Met,"hg19,17:g.7578264G>C, hg19,17:g.7674946G>C, hg38,17:g.7674946G>C",,,0.755,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376620,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.40799,1.7166770696640017,1.06803,1.523163526437013,0.73801,0.9655767632185065,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.65,E,-0.2141,0.2723,-6.9542,-2.07380098452234,0.0514837251885732,Benign,0.4112,ambiguous,-3.592,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195N,NP_000537:p.Ile195Asn,"hg19,17:g.7578264_7578265delinsAT, hg19,17:g.7578265A>T, hg19,17:g.7674947A>T, hg38,17:g.7674946_7674947delinsAT, hg38,17:g.7674947A>T",,,0.840,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","3656084, 376618","Uncertain significance, Conflicting classifications of pathogenicity","1, 1",Likely oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,3.18616,3.6736032962799072,3.70714,3.0353622371921896,3.44665,3.110761118596095,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.65,E,-0.4384,0.2723,-22.2419,-7.4631744305005,0.8622897999050234,Pathogenic,0.998,pathogenic,-4.375,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195P,NP_000537:p.Ile195Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.91533,3.0980708599090576,4.12551,5.900697601376657,4.02042,4.9080138006883285,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.65,E,-0.5453,0.2723,-22.2419,-7.4631744305005,0.8651780772994634,Pathogenic,0.9979,pathogenic,-4.543,available,https://doi.org/10.1101/2022.10.22.513328 +I195Q,NP_000537:p.Ile195Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.17942,3.509040117263794,2.72177,2.9059518541190745,2.950595,3.042685927059537,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.65,E,-0.4659,0.2723,-22.2419,-7.4631744305005,0.8706324413626758,Pathogenic,0.9973,pathogenic,-4.372,available,https://doi.org/10.1101/2022.10.22.513328 +I195R,NP_000537:p.Ile195Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.04839,3.2999067306518555,3.96497,3.388305527372371,5.00668,4.718347763686186,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.65,E,-0.5255,0.2723,-22.2419,-7.4631744305005,0.8701150865360756,Pathogenic,0.9977,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +I195S,NP_000537:p.Ile195Ser,"hg19,17:g.7578265A>C, hg19,17:g.7674947A>C, hg38,17:g.7674947A>C",,,0.865,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376619,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.15419,3.43096661567688,4.23197,4.024229938813565,4.69308,4.589209969406783,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.65,E,-0.4418,0.2723,-22.2419,-6.41975022589998,0.870823739348777,Pathogenic,0.9967,pathogenic,-4.265,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195T,NP_000537:p.Ile195Thr,"hg19,17:g.7578265A>G, hg19,17:g.7674947A>G, hg38,17:g.7674947A>G",,0.0,0.851,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",216077,Pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,3.12645,2.6832516193389893,2.53129,2.7104682283870667,2.82887,2.918459114193533,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.65,E,-0.2908,0.2723,-8.9541,-6.41975022589998,0.8700765958698575,Pathogenic,0.9962,pathogenic,-4.176,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195V,NP_000537:p.Ile195Val,"hg19,17:g.7578266T>C",,,0.725,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.91577,0.7309460639953613,0.91633,0.9307103896010468,0.91605,0.9232401948005233,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.65,E,-0.1707,0.2723,-7.3692,-2.02257112956522,0.0098289755978255,Benign,0.4167,ambiguous,-3.287,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I195W,NP_000537:p.Ile195Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.85336,2.3807411193847656,7.59864,2.600445783572687,10.725999999999999,8.226902891786343,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.65,E,-0.4511,0.2723,-22.2419,-6.41894482551988,0.8669599728249571,Pathogenic,0.9984,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328 +I195Y,NP_000537:p.Ile195Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.58406,2.478738784790039,4.39762,2.430261779734112,6.9908399999999995,6.007160889867055,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.26,,,,,,,,,4.9,,False,4.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.65,E,-0.46,0.2723,-22.2419,-6.96272216613622,0.8694001414318939,Pathogenic,0.9948,pathogenic,-4.516,available,https://doi.org/10.1101/2022.10.22.513328 +R196A,NP_000537:p.Arg196Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.45903,0.5797908306121826,1.66327,1.762508913053537,1.56115,1.6107694565267685,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.4017,0.0888,-22.239,-6.64890589971673,0.7358404843656337,Pathogenic,0.9941,pathogenic,-4.313,available,https://doi.org/10.1101/2022.10.22.513328 +R196C,NP_000537:p.Arg196Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.90696,0.8772556185722351,1.62857,2.3189317776875726,1.267765,1.6129458888437864,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.4106,0.0888,-22.239,-6.78318923477795,0.4002826077062367,Uncertain,0.906,pathogenic,-4.251,available,https://doi.org/10.1101/2022.10.22.513328 +R196D,NP_000537:p.Arg196Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.8142,1.503949522972107,4.00986,2.520952879859705,3.4120299999999997,2.6675764399298525,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.4927,0.0888,-22.239,-6.71430815062119,0.8426073284211704,Pathogenic,0.9986,pathogenic,-4.61,available,https://doi.org/10.1101/2022.10.22.513328 +R196E,NP_000537:p.Arg196Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.51693,1.6564515829086304,2.28912,2.129688904000411,1.903025,1.8233094520002056,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.438,0.0888,-22.239,-6.64558155308853,0.7994082140234413,Pathogenic,0.9856,pathogenic,-4.361,available,https://doi.org/10.1101/2022.10.22.513328 +R196F,NP_000537:p.Arg196Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.00973,0.89165860414505,0.7085,0.5677828368141332,0.359115,0.2887564184070666,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.53,E,-0.4339,0.0888,-22.239,-6.86749286846446,0.8613463913088969,Pathogenic,0.9938,pathogenic,-4.615,available,https://doi.org/10.1101/2022.10.22.513328 +R196G,NP_000537:p.Arg196Gly,"hg19,17:g.7578263G>C, hg38,17:g.7674945G>C",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",232344,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.07079,0.8053992390632629,3.32347,2.986272717792682,2.69713,2.528531358896341,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.4371,0.0888,-22.239,-7.80629060075436,0.8610839621556761,Pathogenic,0.9907,pathogenic,-4.501,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R196H,NP_000537:p.Arg196His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.35554,0.8408684134483337,1.15544,1.339277917425572,1.25549,1.347408958712786,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.3715,0.0888,-22.239,-6.06941447909736,0.076309712736068,Benign,0.8171,pathogenic,-3.864,available,https://doi.org/10.1101/2022.10.22.513328 +R196I,NP_000537:p.Arg196Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30512,0.694922924041748,0.22041,1.1609872831548007,0.262765,0.7330536415774004,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.4311,0.0888,-22.239,-5.71104484075269,0.7013335812488991,Pathogenic,0.9865,pathogenic,-4.354,available,https://doi.org/10.1101/2022.10.22.513328 +R196K,NP_000537:p.Arg196Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.68121,0.558039128780365,2.12585,1.8293168844461165,1.40353,1.2552634422230582,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.53,E,-0.2919,0.0888,-22.239,-4.418970792279,0.3801983393151043,Uncertain,0.8812,pathogenic,-3.894,available,https://doi.org/10.1101/2022.10.22.513328 +R196L,NP_000537:p.Arg196Leu,"hg19,17:g.7578261_7578262delinsAA, hg19,17:g.7578262C>A, hg38,17:g.7674944C>A",,,0.933,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",100814,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.09856,1.153847336769104,0.4551,0.5784142951774351,-0.32172999999999996,-0.2600728524112824,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.4041,0.0888,-22.239,-5.82925530448756,0.150822334273034,Benign,0.9763,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R196M,NP_000537:p.Arg196Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.89029,0.9489787220954896,-0.12415,1.135690086076298,-0.50722,0.12270004303814896,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.37,0.0888,-22.239,-6.18972325937347,0.830974248692133,Pathogenic,0.9927,pathogenic,-4.451,available,https://doi.org/10.1101/2022.10.22.513328 +R196N,NP_000537:p.Arg196Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.88999,0.9251254200935364,2.41973,1.9395975250473043,2.15486,1.9147937625236522,Uncertain,Neutral,Neutral,Uncertain,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.4166,0.0888,-22.239,-6.71430815062119,0.7271140237400785,Pathogenic,0.9966,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328 +R196P,NP_000537:p.Arg196Pro,"hg19,17:g.7578262C>G, hg19,17:g.7674944C>G, hg38,17:g.7674944C>G",,,0.941,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",231165,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.30531,1.9042770862579343,4.09592,4.576769529697911,3.700615,3.9410397648489557,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.5438,0.0888,-22.239,-7.80629060075436,0.8349213564549759,Pathogenic,0.9985,pathogenic,-4.472,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R196Q,NP_000537:p.Arg196Gln,"hg19,17:g.7578262C>T, hg19,17:g.7674944C>T, hg38,17:g.7674944C>T",,3.9763961127e-06,0.888,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",216467,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.57181,0.923121988773346,0.5949,1.9101299863029204,0.5833550000000001,1.2409699931514602,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.2984,0.0888,-6.9513,-4.08074164295966,0.0004966294292797,Benign,0.8076,pathogenic,-3.602,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R196S,NP_000537:p.Arg196Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.7867,0.2241060733795166,2.32823,2.2380262286337325,2.057465,2.0123631143168663,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.4022,0.0888,-22.239,-6.78318923477795,0.6013356277325125,Uncertain,0.9935,pathogenic,-4.229,available,https://doi.org/10.1101/2022.10.22.513328 +R196T,NP_000537:p.Arg196Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.39412,0.0087547302246093,1.2966,1.985243250344784,1.34536,1.689681625172392,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.4066,0.0888,-22.239,-5.81935586418579,0.1785502843952184,Benign,0.9897,pathogenic,-4.069,available,https://doi.org/10.1101/2022.10.22.513328 +R196V,NP_000537:p.Arg196Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.65343,0.6149256229400635,0.47551,1.3544073232715577,0.56447,1.0039186616357787,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.53,E,-0.4182,0.0888,-22.239,-6.75880658149217,0.8409901664940158,Pathogenic,0.9843,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +R196W,NP_000537:p.Arg196Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.32058,1.2138994932174685,1.21122,0.5004412162995625,0.7659,0.41051060814978124,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.53,E,-0.3516,0.0888,-8.9511,-4.38737167945949,0.2708822355643782,Benign,0.8582,pathogenic,-4.151,available,https://doi.org/10.1101/2022.10.22.513328 +R196Y,NP_000537:p.Arg196Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.12518,0.963149070739746,1.14354,0.8404715867813245,0.50918,0.35764579339066227,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.151,,,,,,,,,6.1,,False,6.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.53,E,-0.4232,0.0888,-22.239,-6.86749286846446,0.640133902391459,Uncertain,0.9837,pathogenic,-4.514,available,https://doi.org/10.1101/2022.10.22.513328 +V197A,NP_000537:p.Val197Ala,"hg19,17:g.7578259A>G, hg38,17:g.7674941A>G",,,0.823,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3460294,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.41203,1.990577936172485,2.8983,2.8754398701635644,3.155165,3.143734935081782,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.51,E,-0.3211,0.325,-22.2419,-3.5206512021933,0.1405968956305145,Benign,0.7733,pathogenic,-3.596,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V197C,NP_000537:p.Val197Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.36772,1.4678789377212524,2.11701,2.467610519543139,2.242365,2.417665259771569,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.51,E,-0.349,0.325,-22.2419,-4.11406857854048,0.130186544083736,Benign,0.9432,pathogenic,-3.758,available,https://doi.org/10.1101/2022.10.22.513328 +V197D,NP_000537:p.Val197Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.62917,3.1601486206054688,3.24932,4.60355961582986,3.939245,4.61636480791493,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.51,E,-0.4877,0.325,-22.2419,-6.8456697360114,0.846129836186183,Pathogenic,0.9975,pathogenic,-4.615,available,https://doi.org/10.1101/2022.10.22.513328 +V197E,NP_000537:p.Val197Glu,"hg19,17:g.7578259A>T, hg38,17:g.7674941A>T",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634757,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.62419,3.1341195106506348,4.05476,4.647460498145247,4.339475,4.6358252490726235,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.51,E,-0.445,0.325,-22.2419,-6.8456697360114,0.8548744800576837,Pathogenic,0.9891,pathogenic,-4.52,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V197F,NP_000537:p.Val197Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.67025,2.1258435249328613,3.11871,2.011237348332089,4.39448,3.8407436741660446,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.51,E,-0.3982,0.325,-22.2419,-6.8456697360114,0.8588739220888657,Pathogenic,0.9737,pathogenic,-4.387,available,https://doi.org/10.1101/2022.10.22.513328 +V197G,NP_000537:p.Val197Gly,"hg19,17:g.7578259A>C, hg19,17:g.7674941A>C, hg38,17:g.7674941A>C",,,0.914,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",826051,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.22898,3.29208779335022,5.62823,5.198298834312561,5.428605,5.21363941715628,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.51,E,-0.4469,0.325,-22.2419,-6.75265058190232,0.7291351710970796,Pathogenic,0.9,pathogenic,-4.21,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V197H,NP_000537:p.Val197His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.31121,3.1220738887786865,2.77415,3.287912588780344,4.54268,4.7995612943901715,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.51,E,-0.4907,0.325,-22.2419,-6.8456697360114,0.8572879802209521,Pathogenic,0.9986,pathogenic,-4.547,available,https://doi.org/10.1101/2022.10.22.513328 +V197I,NP_000537:p.Val197Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.757,0.5117456912994385,0.57619,1.1047188628871651,0.666595,0.9308594314435825,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.51,E,-0.1735,0.325,-5.9542,-1.9131308579423,0.0012986975083848,Benign,0.2531,benign,-3.411,available,https://doi.org/10.1101/2022.10.22.513328 +V197K,NP_000537:p.Val197Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.28214,3.1920690536499023,5.98673,5.126025633207264,4.634435,4.204082816603632,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.51,E,-0.4839,0.325,-22.2419,-7.33996685341231,0.8520019517034036,Pathogenic,0.9954,pathogenic,-4.566,available,https://doi.org/10.1101/2022.10.22.513328 +V197L,NP_000537:p.Val197Leu,"hg19,17:g.7578260C>A, hg19,17:g.7578260C>G, hg19,17:g.7674942C>A, hg19,17:g.7674942C>G, hg38,17:g.7674942C>A, hg38,17:g.7674942C>G",,,0.730,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","480766, 216468","Uncertain significance, Uncertain significance","2, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.67365,1.7837259769439695,2.92109,1.22416444888438,1.79737,0.9489072244421899,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.51,E,-0.2488,0.325,-7.9541,-2.53947494754032,0.3558336004282653,Uncertain,0.9179,pathogenic,-3.801,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V197M,NP_000537:p.Val197Met,"hg19,17:g.7578260C>T, hg19,17:g.7674942C>T, hg38,17:g.7674942C>T",,0.0,0.758,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",188060,Likely pathogenic,3,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.70599,2.2086715698242188,2.88163,2.214214163593786,1.79381,1.460102081796893,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.51,E,-0.2468,0.325,-5.7843,-2.05747489701612,0.0076628390895927,Benign,0.8149,pathogenic,-3.648,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V197N,NP_000537:p.Val197Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.23475,3.401599407196045,3.57483,2.86325521336249,3.40479,3.049002606681245,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.51,E,-0.4755,0.325,-22.2419,-6.30858040479212,0.782372239375825,Pathogenic,0.9925,pathogenic,-4.332,available,https://doi.org/10.1101/2022.10.22.513328 +V197P,NP_000537:p.Val197Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.80493,2.441107988357544,5.44864,6.397621147264559,5.126785,5.601275573632279,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.51,E,-0.5254,0.325,-22.2419,-7.33996685341231,0.8615156025895383,Pathogenic,0.9945,pathogenic,-4.412,available,https://doi.org/10.1101/2022.10.22.513328 +V197Q,NP_000537:p.Val197Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.68491,3.047604322433472,3.07551,3.4436740482712684,3.88021,4.064292024135634,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.51,E,-0.4556,0.325,-22.2419,-6.8456697360114,0.8505247353890255,Pathogenic,0.9879,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328 +V197R,NP_000537:p.Val197Arg,"hg38,17:g.7674941_7674942delinsCT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.13142,3.3600659370422363,4.50612,4.1472646469798,3.8187699999999998,3.6393423234899,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.51,E,-0.5049,0.325,-22.2419,-7.33996685341231,0.8364061701708466,Pathogenic,0.9904,pathogenic,-4.592,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V197S,NP_000537:p.Val197Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.24026,2.862804889678955,3.61122,3.766013968496295,3.9257400000000002,4.0031369842481475,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.51,E,-0.4247,0.325,-22.2419,-4.42691594893359,0.1897258266101767,Benign,0.9227,pathogenic,-3.851,available,https://doi.org/10.1101/2022.10.22.513328 +V197T,NP_000537:p.Val197Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.63333,2.163248538970948,2.20136,2.3293382534630904,2.417345,2.481334126731545,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.51,E,-0.3401,0.325,-22.2419,-5.13381694120456,0.4763366100635526,Uncertain,0.8551,pathogenic,-3.963,available,https://doi.org/10.1101/2022.10.22.513328 +V197W,NP_000537:p.Val197Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,15.42562,2.71803879737854,3.72857,3.640842207780546,9.577095,9.533231103890273,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.51,E,-0.3659,0.325,-7.9541,-4.36016292295742,0.7931015519995008,Pathogenic,0.9992,pathogenic,-4.497,available,https://doi.org/10.1101/2022.10.22.513328 +V197Y,NP_000537:p.Val197Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.94733,2.705510139465332,3.37755,2.9693917384970345,5.16244,4.9583608692485175,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.113,,,,,,,,,2.4,,False,2.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.51,E,-0.4417,0.325,-22.2419,-6.8456697360114,0.8449027975939047,Pathogenic,0.9974,pathogenic,-4.382,available,https://doi.org/10.1101/2022.10.22.513328 +E198A,NP_000537:p.Glu198Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.50011,0.0517011284828186,0.47245,0.1108996081108276,0.98628,0.8055048040554138,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,92.67,S,-0.3144,0.0678,-22.2419,-5.98921774853301,0.6718263963587653,Uncertain,0.9123,pathogenic,-4.047,available,https://doi.org/10.1101/2022.10.22.513328 +E198C,NP_000537:p.Glu198Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.46795,-0.2468149065971374,1.1,0.66550181272192,1.283975,1.06672590636096,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,92.67,S,-0.3838,0.0678,-22.2419,-6.34137386382184,0.8517998083968643,Pathogenic,0.9925,pathogenic,-4.444,available,https://doi.org/10.1101/2022.10.22.513328 +E198D,NP_000537:p.Glu198Asp,"hg19,17:g.7578255T>A",,,0.824,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.34383,0.0865107774734497,1.00034,0.2145749890127424,1.172085,0.7792024945063712,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,92.67,S,-0.2801,0.0678,-22.2419,-2.9993919025193,0.0381818939802717,Benign,0.9126,pathogenic,-3.552,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E198F,NP_000537:p.Glu198Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.40789,-0.0086994767189025,0.65816,-0.265186655535311,1.033025,0.5713516722323445,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.67,S,-0.3614,0.0678,-22.2419,-7.35582992108177,0.8587627802061572,Pathogenic,0.9977,pathogenic,-4.528,available,https://doi.org/10.1101/2022.10.22.513328 +E198G,NP_000537:p.Glu198Gly,"hg19,17:g.7578256T>C, hg38,17:g.7674938T>C",,,0.915,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1750606,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.28281,0.8761721849441528,1.41667,0.6652351144526893,1.8497400000000002,1.4740225572263448,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,92.67,S,-0.2622,0.0678,-6.9542,-3.91981923473022,0.0002448667594076,Benign,0.8918,pathogenic,-3.628,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E198H,NP_000537:p.Glu198His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.06743,0.2819430232048034,0.72857,-0.2442805044656887,1.398,0.9115747477671556,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.67,S,-0.3527,0.0678,-22.2419,-6.97765479253872,0.6099948176751155,Uncertain,0.991,pathogenic,-4.201,available,https://doi.org/10.1101/2022.10.22.513328 +E198I,NP_000537:p.Glu198Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.66733,-0.5285781025886536,0.74728,-0.1755660890499588,1.707305,1.2458819554750207,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.67,S,-0.3668,0.0678,-22.2419,-6.43304752804169,0.7716709121966066,Pathogenic,0.9911,pathogenic,-4.385,available,https://doi.org/10.1101/2022.10.22.513328 +E198K,NP_000537:p.Glu198Lys,"hg19,17:g.7578257C>T, hg38,17:g.7674939C>T",,,0.910,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.76396,0.4304366409778595,0.65442,0.1842407557244285,0.70919,0.47410037786221426,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.67,S,-0.3364,0.0678,-22.2419,-6.67699439893473,0.5185595493742274,Uncertain,0.9619,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E198L,NP_000537:p.Glu198Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.13373,-0.1868313550949096,0.34014,-0.5346168704512633,0.7369349999999999,0.2995565647743683,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.67,S,-0.3689,0.0678,-22.2419,-6.04569525278152,0.3913484744115144,Uncertain,0.9908,pathogenic,-4.132,available,https://doi.org/10.1101/2022.10.22.513328 +E198M,NP_000537:p.Glu198Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.17933,0.005394160747528,0.53844,-0.303189930690142,0.858885,0.438070034654929,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.67,S,-0.3177,0.0678,-22.2419,-6.29179151053515,0.7448417447284595,Pathogenic,0.9884,pathogenic,-4.399,available,https://doi.org/10.1101/2022.10.22.513328 +E198N,NP_000537:p.Glu198Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.55314,0.2241225838661193,0.89524,0.0706764106077401,1.2241900000000001,0.81190820530387,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,92.67,S,-0.3406,0.0678,-22.2419,-3.84501911807093,0.5471324505606959,Uncertain,0.9839,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +E198P,NP_000537:p.Glu198Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.56602,2.218320369720459,1.10068,4.891461897922538,2.3333500000000003,4.228740948961269,Uncertain,Destabilizing,Destabilizing,Uncertain,Destabilizing,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,92.67,S,-0.4714,0.0678,-22.2419,-7.88517255993179,0.546307580719817,Uncertain,0.9952,pathogenic,-4.22,available,https://doi.org/10.1101/2022.10.22.513328 +E198Q,NP_000537:p.Glu198Gln,"hg38,17:g.7674939C>G",,,0.889,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.97646,0.1867783069610595,-0.32143,0.0973604023435564,0.327515,0.5369102011717782,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.67,S,-0.2869,0.0678,-22.2419,-3.67879250789538,0.0440181537901666,Benign,0.8704,pathogenic,-3.859,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E198R,NP_000537:p.Glu198Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.23001,0.3327066004276275,0.50952,-0.2205961603561057,0.869765,0.5047069198219472,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.67,S,-0.3969,0.0678,-22.2419,-6.11022330690454,0.3099247253021857,Benign,0.9637,pathogenic,-4.328,available,https://doi.org/10.1101/2022.10.22.513328 +E198S,NP_000537:p.Glu198Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.37531,0.1683567762374878,0.69898,0.3874703343988356,1.037145,0.8813901671994178,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,92.67,S,-0.3279,0.0678,-22.2419,-5.3672337520513,0.2040811605993631,Benign,0.9341,pathogenic,-3.994,available,https://doi.org/10.1101/2022.10.22.513328 +E198T,NP_000537:p.Glu198Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.74659,0.0050495266914367,0.49796,0.1818945519679149,1.1222750000000001,0.9642422759839575,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,92.67,S,-0.3438,0.0678,-22.2419,-6.09562816383539,0.5761769011089655,Uncertain,0.9712,pathogenic,-4.117,available,https://doi.org/10.1101/2022.10.22.513328 +E198V,NP_000537:p.Glu198Val,"hg38,17:g.7674938T>A",,,0.926,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.29634,-0.5415311455726624,1.05714,0.0037461339022415,1.67674,1.1500430669511206,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,92.67,S,-0.3277,0.0678,-22.2419,-6.1303990407713,0.4552757701320393,Uncertain,0.9698,pathogenic,-4.025,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E198W,NP_000537:p.Glu198Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.66587,0.3642545044422149,0.62041,-0.630092538380948,1.14314,0.5178887308095259,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.67,S,-0.3715,0.0678,-22.2419,-7.35582992108177,0.856607791247208,Pathogenic,0.9988,pathogenic,-4.755,available,https://doi.org/10.1101/2022.10.22.513328 +E198Y,NP_000537:p.Glu198Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.46318,0.2036279439926147,0.45102,-0.1381374285332021,0.9571,0.6625212857333989,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.045,,,Uncertain,,Uncertain,,,Uncertain,57.0,,False,57.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,92.67,S,-0.3623,0.0678,-22.2419,-7.35582992108177,0.8565579991117023,Pathogenic,0.9964,pathogenic,-4.578,available,https://doi.org/10.1101/2022.10.22.513328 +G199A,NP_000537:p.Gly199Ala,"hg38,17:g.7674935C>G",,,0.888,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.13038,1.509732365608215,1.03469,1.4358746664215607,1.582535,1.7831273332107804,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.2948,0.1416,-7.3721,-4.80334672416214,6.86442044252819e-05,Benign,0.7779,pathogenic,-3.74,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G199C,NP_000537:p.Gly199Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.7798,0.7123243808746338,1.61293,1.7664077770743158,1.6963650000000001,1.773103888537158,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4304,0.1416,-22.2448,-6.8709400035319,0.5037951790693465,Uncertain,0.9256,pathogenic,-4.322,available,https://doi.org/10.1101/2022.10.22.513328 +G199D,NP_000537:p.Gly199Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.87965,1.371357560157776,0.63435,0.897873403904971,1.2570000000000001,1.3887617019524856,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4309,0.1416,-22.2448,-6.05306704732168,0.1733264526690307,Benign,0.9505,pathogenic,-4.043,available,https://doi.org/10.1101/2022.10.22.513328 +G199E,NP_000537:p.Gly199Glu,"hg19,17:g.7578253C>T, hg19,17:g.7674935C>T, hg38,17:g.7674935C>T",,,0.880,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",582257,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.97517,1.4709641933441162,1.32925,1.3479098065400266,1.6522100000000002,1.6615399032700133,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.3522,0.1416,-6.9571,-3.96135340166989,0.0299906564285995,Benign,0.9647,pathogenic,-3.885,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G199F,NP_000537:p.Gly199Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.29412,1.274000883102417,0.39048,0.8314044246052593,0.8422999999999999,1.0627622123026297,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4685,0.1416,-22.2448,-5.88443302893061,0.848709424045369,Pathogenic,0.9939,pathogenic,-4.687,available,https://doi.org/10.1101/2022.10.22.513328 +G199H,NP_000537:p.Gly199His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.70045,1.1914544105529783,0.6085,0.7427479291753788,1.1544750000000001,1.2215989645876895,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4432,0.1416,-22.2448,-4.69049149783605,0.0537274039140483,Benign,0.9886,pathogenic,-4.295,available,https://doi.org/10.1101/2022.10.22.513328 +G199I,NP_000537:p.Gly199Ile,"hg19,17:g.7578253_7578254delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.97367,1.971896290779113,4.78605,2.83241156125027,4.37986,3.403040780625135,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.5142,0.1416,-22.2448,-7.38569882570294,0.8509103896318686,Pathogenic,0.9905,pathogenic,-4.673,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G199K,NP_000537:p.Gly199Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.17888,1.5404210090637207,0.81259,0.8868088451465289,0.995735,1.0328444225732645,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4632,0.1416,-22.2448,-7.64307823678845,0.7976349428260668,Pathogenic,0.9923,pathogenic,-4.393,available,https://doi.org/10.1101/2022.10.22.513328 +G199L,NP_000537:p.Gly199Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42522,1.4145251512527466,1.27755,1.0271234608348836,1.351385,1.2261717304174418,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4824,0.1416,-22.2448,-7.38569882570294,0.7892289216637154,Pathogenic,0.9872,pathogenic,-4.56,available,https://doi.org/10.1101/2022.10.22.513328 +G199M,NP_000537:p.Gly199Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.27605,1.3312665224075315,1.30272,1.2526603944215091,1.289385,1.2643551972107545,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4206,0.1416,-22.2448,-7.38569882570294,0.728915006186129,Pathogenic,0.9883,pathogenic,-4.59,available,https://doi.org/10.1101/2022.10.22.513328 +G199N,NP_000537:p.Gly199Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.43248,1.0342977046966553,0.15986,0.4756912327928997,0.79617,0.9540856163964498,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4312,0.1416,-22.2448,-6.3901912466579,0.5371317316087846,Uncertain,0.9299,pathogenic,-4.014,available,https://doi.org/10.1101/2022.10.22.513328 +G199P,NP_000537:p.Gly199Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.78406,2.211193799972534,17.86054,6.96751856271145,12.3223,6.8757892813557255,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.5283,0.1416,-22.2448,-6.67581907822099,0.811693595457798,Pathogenic,0.9976,pathogenic,-4.455,available,https://doi.org/10.1101/2022.10.22.513328 +G199Q,NP_000537:p.Gly199Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.85964,1.478709101676941,0.75646,1.2645279537121428,0.8080499999999999,1.0620839768560715,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4341,0.1416,-22.2448,-6.54974915504437,0.5479391245755375,Uncertain,0.9798,pathogenic,-4.363,available,https://doi.org/10.1101/2022.10.22.513328 +G199R,NP_000537:p.Gly199Arg,"hg19,17:g.7578254C>T, hg38,17:g.7674936C>T",,,0.883,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1015039,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.22529,1.5234806537628174,1.27857,0.8690616983305949,1.25193,1.0471758491652974,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.3794,0.1416,-8.957,-7.64307823678845,0.8380371354316876,Pathogenic,0.9824,pathogenic,-4.342,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G199S,NP_000537:p.Gly199Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.01497,1.5394293069839478,0.5585,1.6076555350152149,1.286735,1.8113127675076073,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.3766,0.1416,-22.2448,-6.02974354335764,0.2749630817254707,Benign,0.7501,pathogenic,-4.172,available,https://doi.org/10.1101/2022.10.22.513328 +G199T,NP_000537:p.Gly199Thr,"hg38,17:g.7674935_7674936delinsGT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.57007,1.852608561515808,1.15272,2.3542543035184087,1.861395,2.4621621517592045,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4535,0.1416,-22.2448,-6.8709400035319,0.8369289085395977,Pathogenic,0.9385,pathogenic,-4.364,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G199V,NP_000537:p.Gly199Val,"hg19,17:g.7578253C>A, hg19,17:g.7674935C>A, hg38,17:g.7674935C>A",,,0.899,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",451799,Likely pathogenic,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,4.37332,1.9626845121383667,5.03741,2.492362866288133,4.7053650000000005,3.432841433144066,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4574,0.1416,-22.2448,-7.38569882570294,0.8217192873988828,Pathogenic,0.9687,pathogenic,-4.576,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G199W,NP_000537:p.Gly199Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.15189,1.521793246269226,0.9,0.7334062873277125,1.025945,0.9426481436638563,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4683,0.1416,-22.2448,-5.88443302893061,0.8335051489904379,Pathogenic,0.9862,pathogenic,-4.64,available,https://doi.org/10.1101/2022.10.22.513328 +G199Y,NP_000537:p.Gly199Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.34726,1.361750602722168,0.43605,1.02449393163707,0.891655,1.1858769658185349,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,,,Uncertain,,Uncertain,,,Uncertain,121.9,,False,121.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,89.17,S,-0.4689,0.1416,-22.2448,-5.88443302893061,0.7942430489742779,Pathogenic,0.9849,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328 +N200A,NP_000537:p.Asn200Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.99629,0.9660030603408812,1.6017,1.2736538007046634,1.298995,1.1349719003523318,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.2718,0.6214,-22.2448,-4.70606374613329,0.7178942931373743,Pathogenic,0.8658,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328 +N200C,NP_000537:p.Asn200Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.43171,0.1578187942504882,1.00272,1.416238269232979,0.717215,0.9239741346164895,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.2538,0.6214,-8.957,-3.38068171152327,0.0182571053610159,Benign,0.5899,pathogenic,-3.72,available,https://doi.org/10.1101/2022.10.22.513328 +N200D,NP_000537:p.Asn200Asp,"hg19,17:g.7578251T>C, hg38,17:g.7674933T>C",,,0.840,"COSMIC,ClinVar,saturation_mutlist",1061739,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.27163,0.0891224145889282,0.10748,1.268792599226094,0.189555,0.770211299613047,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,89.46,-,-0.275,0.6214,-22.2448,-3.29350549214925,0.6650299812568407,Uncertain,0.7248,pathogenic,-3.643,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N200E,NP_000537:p.Asn200Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.44061,0.7168933749198914,0.07993,1.426686223581523,0.26027,0.9336481117907615,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.3021,0.6214,-22.2448,-3.27573005752842,0.2038018284710903,Benign,0.963,pathogenic,-3.962,available,https://doi.org/10.1101/2022.10.22.513328 +N200F,NP_000537:p.Asn200Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.56122,0.6817286610603333,-0.33741,-0.3014888562267315,-0.449315,-0.4313544281133658,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.256,0.6214,-7.957,-3.80485558407959,0.6461120110354758,Uncertain,0.954,pathogenic,-4.016,available,https://doi.org/10.1101/2022.10.22.513328 +N200G,NP_000537:p.Asn200Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.24502,1.6868562698364258,3.1415,2.8880395960238974,3.19326,3.0665297980119486,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.2347,0.6214,-8.957,-6.18601377560582,0.068765973426231,Benign,0.8668,pathogenic,-3.796,available,https://doi.org/10.1101/2022.10.22.513328 +N200H,NP_000537:p.Asn200His,"hg19,17:g.7578251T>G, hg38,17:g.7674933T>G",,,0.850,"ClinVar,saturation_mutlist",2006345,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.03603,0.4782987833023071,0.9449,0.167348261681246,0.454435,0.065659130840623,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.2767,0.6214,-22.2448,-4.73925841340621,0.3629318295858595,Uncertain,0.5591,ambiguous,-3.619,available,https://doi.org/10.1101/2022.10.22.513328 +N200I,NP_000537:p.Asn200Ile,"hg38,17:g.7674932T>A",,,0.792,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.56755,0.6546464562416077,-0.05408,-0.1322421350551067,-0.810815,-0.8498960675275533,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.2461,0.6214,-7.3721,-3.88280033074422,0.0021322772332192,Benign,0.8104,pathogenic,-3.804,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N200K,NP_000537:p.Asn200Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.57017,1.390042066574097,1.3119,1.4578274465522607,0.37086500000000006,0.4438287232761304,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.275,0.6214,-22.2448,-4.36009452915514,0.5441893776244784,Uncertain,0.9759,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +N200L,NP_000537:p.Asn200Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.47421,0.0465238094329834,-0.47585,-0.430327986170067,-0.9750300000000001,-0.9522689930850335,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.3284,0.6214,-22.2448,-6.17706167855285,0.5522632701308042,Uncertain,0.8329,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328 +N200M,NP_000537:p.Asn200Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.62051,0.2802042961120605,0.09898,0.1105213758016926,-0.7607649999999999,-0.7549943120991537,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.2826,0.6214,-22.2448,-6.17706167855285,0.4474937082728807,Uncertain,0.8712,pathogenic,-4.194,available,https://doi.org/10.1101/2022.10.22.513328 +N200P,NP_000537:p.Asn200Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.24501,2.3469021320343018,5.20238,5.233364233817254,4.723694999999999,4.739187116908627,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,89.46,-,-0.4374,0.6214,-22.2448,-6.87159515347392,0.3437941992529058,Uncertain,0.9559,pathogenic,-4.11,available,https://doi.org/10.1101/2022.10.22.513328 +N200Q,NP_000537:p.Asn200Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.03237,0.7176105976104736,0.61259,0.9048024321079712,0.32248,0.4685862160539856,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.2657,0.6214,-22.2448,-3.75604555492313,0.7776234660143829,Pathogenic,0.9355,pathogenic,-3.86,available,https://doi.org/10.1101/2022.10.22.513328 +N200R,NP_000537:p.Asn200Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.76561,1.3401203155517578,1.35578,0.7541135135457946,0.295085,-0.005748243227102712,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.3071,0.6214,-22.2448,-4.97345972867756,0.5955775745557251,Uncertain,0.9725,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328 +N200S,NP_000537:p.Asn200Ser,"hg19,17:g.7578250T>C, hg38,17:g.7674932T>C",,,0.678,"COSMIC,ClinVar,saturation_mutlist",924379,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.20395,0.684943437576294,1.42823,1.6884394534165292,1.31609,1.4461947267082647,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.1458,0.6214,-3.4653,-2.69652319272738,3.4334945744070325e-05,Benign,0.2322,benign,-3.204,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N200T,NP_000537:p.Asn200Thr,"hg38,17:g.7674932T>G",,,0.768,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.2007,1.0503768920898438,0.74694,1.1292204100114835,0.47382,0.6649602050057417,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,89.46,-,-0.2153,0.6214,-7.3721,-2.68225003822747,0.0018563863109407,Benign,0.6728,pathogenic,-3.621,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N200V,NP_000537:p.Asn200Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.3354,0.6501913666725159,-0.31905,0.1765901881714521,-0.327225,-0.07940490591427393,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.3154,0.6214,-22.2448,-5.93954811469127,0.4932106671626945,Uncertain,0.8136,pathogenic,-3.994,available,https://doi.org/10.1101/2022.10.22.513328 +N200W,NP_000537:p.Asn200Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.02922,0.5632845759391785,-1.02415,-0.2113488104394001,-1.026685,-0.6202844052197001,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.334,0.6214,-22.2448,-5.66554857065075,0.6537730166788992,Uncertain,0.9867,pathogenic,-4.468,available,https://doi.org/10.1101/2022.10.22.513328 +N200Y,NP_000537:p.Asn200Tyr,"hg19,17:g.7578251T>A, hg38,17:g.7674933T>A",,,0.900,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2450739,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.7438,0.7962810397148132,-0.02517,0.0499660480011859,-0.384485,-0.3469169759994071,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.032,,,,,,,,,24.8,,False,24.8,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,89.46,-,-0.3125,0.6214,-22.2448,-5.66554857065075,0.7598088753886141,Pathogenic,0.7838,pathogenic,-4.262,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L201A,NP_000537:p.Leu201Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.31393,-0.0276360511779785,0.48741,0.6083474295504299,0.40066999999999997,0.46113871477521495,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.95,T,-0.142,2.2788,-8.957,-2.40647612735403,0.0001166967365213,Benign,0.1339,benign,-3.321,available,https://doi.org/10.1101/2022.10.22.513328 +L201C,NP_000537:p.Leu201Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.21544,-0.1210834383964538,1.19286,1.287116561787,0.70415,0.7512782808935,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.95,T,-0.1262,2.2788,-7.957,-1.15700260055409,0.0172092318306046,Benign,0.3744,ambiguous,-3.562,available,https://doi.org/10.1101/2022.10.22.513328 +L201D,NP_000537:p.Leu201Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.24858,-0.1220822930335998,0.27211,0.323939959244664,0.260345,0.286259979622332,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.95,T,-0.3314,2.2788,-22.2448,-2.55040462010664,0.0045385808441924,Benign,0.4619,ambiguous,-3.641,available,https://doi.org/10.1101/2022.10.22.513328 +L201E,NP_000537:p.Leu201Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.24049,0.0260629653930664,0.1051,0.2782242438606425,0.172795,0.25935712193032123,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.95,T,-0.2265,2.2788,-7.957,-1.62484319601199,0.0006284759351469,Benign,0.2412,benign,-3.45,available,https://doi.org/10.1101/2022.10.22.513328 +L201F,NP_000537:p.Leu201Phe,"hg38,17:g.7674928C>A, hg38,17:g.7674928C>G",,,0.446,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01504,0.0913593173027038,-0.0949,0.3050379998887692,-0.03993,0.16003899994438459,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,90.95,T,-0.0704,2.2788,-7.957,-3.07549202194472,0.004922315040853,Benign,0.1485,benign,-3.371,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L201G,NP_000537:p.Leu201Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14965,0.2527200579643249,0.79388,1.0063767471297702,0.471765,0.5780133735648851,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.95,T,-0.2847,2.2788,-22.2448,-5.2755006118749,0.0059431267745625,Benign,0.2483,benign,-3.584,available,https://doi.org/10.1101/2022.10.22.513328 +L201H,NP_000537:p.Leu201His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28252,0.0402235984802246,0.04116,0.1538965423641336,0.16183999999999998,0.21820827118206682,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.95,T,-0.1793,2.2788,-7.957,-2.51710073751225,7.272533883244776e-05,Benign,0.175,benign,-3.244,available,https://doi.org/10.1101/2022.10.22.513328 +L201I,NP_000537:p.Leu201Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.36104,0.0730525255203247,0.68231,0.3857921305215678,0.521675,0.3734160652607839,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,90.95,T,-0.084,2.2788,-22.2448,-3.32346447203425,0.0151393179595806,Benign,0.1171,benign,-3.426,available,https://doi.org/10.1101/2022.10.22.513328 +L201K,NP_000537:p.Leu201Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.06437,0.0962294340133667,0.19014,0.4134748613279754,0.062885,0.1745524306639877,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,90.95,T,-0.2984,2.2788,-22.2448,-4.34109503692497,6.954692770157944e-05,Benign,0.2691,benign,-3.55,available,https://doi.org/10.1101/2022.10.22.513328 +L201M,NP_000537:p.Leu201Met,"hg19,17:g.7578248A>T, hg38,17:g.7674930A>T",,,0.485,"ClinVar,saturation_mutlist",1751128,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.03214,0.1129661798477172,-0.04184,0.4434082088220031,-0.03699,0.20563410441100155,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,90.95,T,-0.0314,2.2788,-7.3721,-0.566286831019014,8.739344011707353e-05,Benign,0.0943,benign,-3.219,available,https://doi.org/10.1101/2022.10.22.513328 +L201N,NP_000537:p.Leu201Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.16918,0.075650155544281,-0.0068,0.4413236663504022,0.08119,0.3052518331752011,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.95,T,-0.1768,2.2788,-2.4814,-1.69931918644977,0.0001308633320518,Benign,0.2196,benign,-3.346,available,https://doi.org/10.1101/2022.10.22.513328 +L201P,NP_000537:p.Leu201Pro,"hg38,17:g.7674929_7674930delinsGG",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.53182,-0.1617102026939392,-0.29932,1.0913705822743591,-0.41557,0.2797752911371796,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.95,T,-0.2038,2.2788,-4.7092,-0.722144173015352,8.045290590727062e-09,Benign,0.0876,benign,-3.162,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L201Q,NP_000537:p.Leu201Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22529,0.0748500227928161,0.21463,0.6153995430355108,0.21996,0.4203447715177554,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.95,T,-0.1316,2.2788,-2.8486,-0.807299698791689,9.279905668473807e-08,Benign,0.0982,benign,-3.025,available,https://doi.org/10.1101/2022.10.22.513328 +L201R,NP_000537:p.Leu201Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.08851,0.1160972118377685,0.10272,0.3415559255600525,0.095615,0.21503296278002626,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,90.95,T,-0.2222,2.2788,-8.957,-2.50036232905976,0.0002867534106675,Benign,0.1793,benign,-3.396,available,https://doi.org/10.1101/2022.10.22.513328 +L201S,NP_000537:p.Leu201Ser,"hg38,17:g.7674929A>G",,,0.505,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.17245,-0.0566369295120239,0.20918,0.5349620912671679,0.190815,0.35370604563358393,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.95,T,-0.1331,2.2788,-1.2567,-0.196241491882778,3.9402182750519955e-09,Benign,0.1323,benign,-2.974,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L201T,NP_000537:p.Leu201Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.54314,-0.0174766778945922,0.2483,0.5975811944047129,0.39571999999999996,0.5703605972023564,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.95,T,-0.1401,2.2788,-7.957,-1.5589299240126,3.104088341486957e-05,Benign,0.1305,benign,-3.25,available,https://doi.org/10.1101/2022.10.22.513328 +L201V,NP_000537:p.Leu201Val,"hg38,17:g.7674930A>C",,,0.447,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.5867,0.1114331483840942,0.59932,0.5327940251284996,0.59301,0.5597470125642499,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.95,T,-0.0524,2.2788,-8.957,-2.17201643401262,0.0025459696746585,Benign,0.0939,benign,-3.244,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L201W,NP_000537:p.Leu201Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.1452,-0.0926874279975891,0.08299,-0.0300870797630603,-0.031105,-0.08764353988153015,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,90.95,T,-0.2425,2.2788,-22.2448,-4.53905235236055,0.4061847922828556,Uncertain,0.2357,benign,-3.904,available,https://doi.org/10.1101/2022.10.22.513328 +L201Y,NP_000537:p.Leu201Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.0604,0.0407739281654357,-0.23707,0.367045418920483,-0.088335,0.2137227094602415,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,90.9,,False,90.9,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,90.95,T,-0.1675,2.2788,-8.957,-4.53905235236055,0.0078126119531683,Benign,0.3429,ambiguous,-3.489,available,https://doi.org/10.1101/2022.10.22.513328 +R202A,NP_000537:p.Arg202Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.61836,0.4263608455657959,0.46463,0.8176393370102333,0.5414950000000001,0.7179996685051167,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.1546,2.0378,-8.957,-2.88081380414296,0.0016189020730378,Benign,0.2512,benign,-3.375,available,https://doi.org/10.1101/2022.10.22.513328 +R202C,NP_000537:p.Arg202Cys,"hg19,17:g.7578245G>A, hg38,17:g.7674927G>A",3.18654005481e-05,2.78352155241e-05,0.498,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127818,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.90922,0.2816876173019409,0.93673,1.1810794930342807,0.922975,1.0451497465171404,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.1532,2.0378,-6.9571,-2.09111881832108,0.0006767326895455,Benign,0.116,benign,-3.308,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R202D,NP_000537:p.Arg202Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.40296,0.8779754638671875,0.18265,0.6634238132035305,0.292805,0.5331919066017652,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.3134,2.0378,-22.2448,-3.11285594195369,0.0076304962539488,Benign,0.325,benign,-3.55,available,https://doi.org/10.1101/2022.10.22.513328 +R202E,NP_000537:p.Arg202Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48244,0.7512297630310059,0.2966,0.6762231246794709,0.38952,0.5793315623397355,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.2587,2.0378,-22.2448,-3.00713811111707,0.0018219454667677,Benign,0.2762,benign,-3.502,available,https://doi.org/10.1101/2022.10.22.513328 +R202F,NP_000537:p.Arg202Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.08465,0.4352048635482788,-0.03946,0.3978936842238711,0.022595,0.24127184211193556,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.2546,2.0378,-22.2448,-2.28820530764412,0.0314175226310784,Benign,0.3891,ambiguous,-3.568,available,https://doi.org/10.1101/2022.10.22.513328 +R202G,NP_000537:p.Arg202Gly,"hg19,17:g.7578245G>C, hg38,17:g.7674927G>C",,,0.483,"COSMIC,ClinVar,saturation_mutlist",231661,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.78311,0.9328920245170592,1.12313,1.0103632571979455,0.95312,0.8967366285989727,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.19,2.0378,-8.957,-1.3870717050981,0.0001162284074562,Benign,0.1515,benign,-3.34,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R202H,NP_000537:p.Arg202His,"hg19,17:g.7578244C>T, hg38,17:g.7674926C>T",,,0.528,"COSMIC,ClinVar,saturation_mutlist",135358,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.70134,0.3050671219825744,-0.1568,0.2950134268321136,0.27227,0.4981767134160568,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.0842,2.0378,-1.0929,0.19866576258103,2.2650299446572743e-09,Benign,0.0714,benign,-2.776,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R202I,NP_000537:p.Arg202Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.40395,0.8013044595718384,0.67687,1.2611383791203112,1.04041,1.3325441895601555,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.2518,2.0378,-22.2448,-2.91832255923989,0.1461732516526155,Benign,0.4061,ambiguous,-3.851,available,https://doi.org/10.1101/2022.10.22.513328 +R202K,NP_000537:p.Arg202Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.18485,0.2497051954269409,0.26973,0.4148789246961715,0.22729,0.2998644623480857,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,94.56,T,-0.0346,2.0378,-6.9571,-1.48343747555783,2.0017178497730727e-06,Benign,0.1535,benign,-3.07,available,https://doi.org/10.1101/2022.10.22.513328 +R202L,NP_000537:p.Arg202Leu,"hg19,17:g.7578244C>A, hg38,17:g.7674926C>A",,,0.530,"COSMIC,ClinVar,saturation_mutlist",182932,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.31957,0.3561798930168152,0.10782,0.2548670105745904,0.21369500000000002,0.2872185052872952,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.124,2.0378,-2.4814,-1.16836799688307,1.5510637556800205e-06,Benign,0.1554,benign,-3.124,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R202M,NP_000537:p.Arg202Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.40816,0.3285767436027527,0.60136,0.4361252126915871,0.50476,0.4221426063457936,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.1148,2.0378,-7.3721,-1.14857701936401,1.208321248346084e-05,Benign,0.3412,ambiguous,-3.306,available,https://doi.org/10.1101/2022.10.22.513328 +R202N,NP_000537:p.Arg202Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.39746,0.4507415890693664,-0.12653,0.3383612878817682,0.135465,0.36791064394088413,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.1614,2.0378,-7.3721,-0.797235299210452,0.0001923667934149,Benign,0.2568,benign,-3.168,available,https://doi.org/10.1101/2022.10.22.513328 +R202P,NP_000537:p.Arg202Pro,"hg19,17:g.7578244C>G, hg38,17:g.7674925_7674926delinsCG, hg38,17:g.7674926C>G",,,0.528,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",826165,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.67882,2.2613019943237305,2.38673,4.9403229976482725,1.532775,2.8095714988241363,Uncertain,Uncertain,Destabilizing,Neutral,Uncertain,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.3645,2.0378,-22.2448,-3.66857640737189,0.0204034678727542,Benign,0.5449,ambiguous,-3.666,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R202Q,NP_000537:p.Arg202Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.51472,0.3534864783287048,0.30884,0.6330899416708741,0.41178,0.573904970835437,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.1059,2.0378,-4.3721,-1.66575263570409,9.549324138335948e-09,Benign,0.0845,benign,-2.947,available,https://doi.org/10.1101/2022.10.22.513328 +R202S,NP_000537:p.Arg202Ser,"hg38,17:g.7674927G>T",,,0.486,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.71542,0.528313398361206,0.24354,0.9390295416828922,0.47947999999999996,0.8272247708414461,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.2229,2.0378,-22.2448,-2.81419087979135,0.000351405816512,Benign,0.28,benign,-3.262,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R202T,NP_000537:p.Arg202Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.88296,0.626659095287323,-0.07823,1.1217838699921034,0.402365,1.0023719349960518,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.1595,2.0378,-8.957,-2.94686413850029,0.0005201075797512,Benign,0.263,benign,-3.434,available,https://doi.org/10.1101/2022.10.22.513328 +R202V,NP_000537:p.Arg202Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.57928,0.8785960078239441,0.2585,1.0460896282751255,0.91889,1.3126848141375627,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.1711,2.0378,-8.957,-2.27877744646473,0.0213437490764548,Benign,0.3739,ambiguous,-3.647,available,https://doi.org/10.1101/2022.10.22.513328 +R202W,NP_000537:p.Arg202Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.56036,0.4196124672889709,-0.06531,0.1969689082469733,0.247525,0.37866445412348665,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.1723,2.0378,-8.957,-1.34112861336191,0.0049112016739677,Benign,0.1695,benign,-3.606,available,https://doi.org/10.1101/2022.10.22.513328 +R202Y,NP_000537:p.Arg202Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.25471,0.4331253170967102,-0.12619,0.4669711665728909,0.06426,0.3608405832864454,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.09,,,Uncertain,,Uncertain,,,Uncertain,63.7,,False,63.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.56,T,-0.1629,2.0378,-6.3721,-0.119316417623896,0.0001134356086776,Benign,0.2333,benign,-3.407,available,https://doi.org/10.1101/2022.10.22.513328 +V203A,NP_000537:p.Val203Ala,"hg38,17:g.7674923A>G",,,0.526,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.35015,1.0894718170166016,1.4949,1.1848307808031926,1.4225249999999998,1.2674903904015964,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.63,-,-0.1354,1.1312,-0.3873,0.605143927663759,3.7600521567679115e-22,Benign,0.1,benign,-2.698,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V203C,NP_000537:p.Val203Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.52626,0.9761266708374025,1.61259,1.4130867628894213,1.0694249999999998,0.9696733814447106,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.63,-,-0.1989,1.1312,-7.3721,-1.31820944315504,2.0518429432132102e-05,Benign,0.6638,pathogenic,-3.04,available,https://doi.org/10.1101/2022.10.22.513328 +V203D,NP_000537:p.Val203Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.48928,2.831214189529419,3.88265,2.1019808160455264,3.685965,2.795630408022763,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.63,-,-0.4135,1.1312,-22.2448,-4.648604673011,0.0282699663548481,Benign,0.921,pathogenic,-3.617,available,https://doi.org/10.1101/2022.10.22.513328 +V203E,NP_000537:p.Val203Glu,"hg19,17:g.7578241A>T, hg38,17:g.7674923A>T",,,0.630,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",644883,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.32941,2.533562421798706,5.10578,1.44500994756265,4.217595,2.3872099737813253,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.63,-,-0.3708,1.1312,-22.2448,-4.648604673011,0.0501222567511481,Benign,0.8955,pathogenic,-3.578,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V203F,NP_000537:p.Val203Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,17.97974,1.739485502243042,9.24898,0.4995726673488632,13.61436,9.239656333674432,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.63,-,-0.3241,1.1312,-22.2448,-5.11566355519937,0.0049972157915388,Benign,0.865,pathogenic,-3.485,available,https://doi.org/10.1101/2022.10.22.513328 +V203G,NP_000537:p.Val203Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.62726,2.353534698486328,3.93605,2.8661574013089224,3.2816549999999998,2.7467087006544615,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.63,-,-0.3727,1.1312,-22.2448,-4.2329573305272,0.000481486211549,Benign,0.3338,benign,-3.138,available,https://doi.org/10.1101/2022.10.22.513328 +V203H,NP_000537:p.Val203His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.35315,2.217390775680542,6.33605,1.0001737352551947,7.8446,5.1766618676275975,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.63,-,-0.4165,1.1312,-22.2448,-5.11566355519937,0.0101663235880189,Benign,0.9702,pathogenic,-3.332,available,https://doi.org/10.1101/2022.10.22.513328 +V203I,NP_000537:p.Val203Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.94902,0.629155158996582,0.35612,-0.4157430781558541,1.1525699999999999,0.7666384609220729,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.63,-,-0.1147,1.1312,-8.957,-2.94329085917356,3.6445472307610144e-05,Benign,0.228,benign,-3.202,available,https://doi.org/10.1101/2022.10.22.513328 +V203K,NP_000537:p.Val203Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.77494,2.2512481212615967,5.82177,1.4292413684626517,4.298355,2.102090684231326,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.63,-,-0.4098,1.1312,-22.2448,-5.11566355519937,0.0476967810697828,Benign,0.9634,pathogenic,-3.612,available,https://doi.org/10.1101/2022.10.22.513328 +V203L,NP_000537:p.Val203Leu,"hg19,17:g.7578242C>A, hg19,17:g.7578242C>G, hg19,17:g.7674924C>A, hg19,17:g.7674924C>G, hg38,17:g.7674924C>A, hg38,17:g.7674924C>G",,,0.506,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","482235, 482218","Uncertain significance, Uncertain significance","2, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.41819,1.3827829360961914,2.5449,0.0412614566851504,1.9815450000000001,0.7297257283425752,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.63,-,-0.1746,1.1312,-7.957,-1.57779146542502,0.0017716703619329,Benign,0.7401,pathogenic,-3.241,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V203M,NP_000537:p.Val203Met,"hg19,17:g.7578242C>T, hg38,17:g.7674924C>T",,,0.519,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182933,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.97819,1.522202730178833,2.2017,0.5523595368654535,2.089945,1.2652747684327266,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.63,-,-0.2566,1.1312,-22.2448,-3.60071629476165,0.0116913567518064,Benign,0.5787,pathogenic,-3.49,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V203N,NP_000537:p.Val203Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.53855,2.6566081047058105,2.66259,1.2388924674814772,3.10057,2.3887212337407386,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.63,-,-0.4014,1.1312,-22.2448,-3.26511550718159,0.0186188879414486,Benign,0.8106,pathogenic,-3.471,available,https://doi.org/10.1101/2022.10.22.513328 +V203P,NP_000537:p.Val203Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.42259,1.898267149925232,4.09728,2.604258567347438,4.759935,4.013424283673719,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.63,-,-0.3703,1.1312,-6.3721,-1.36074022148326,8.173724054183048e-07,Benign,0.7184,pathogenic,-3.02,available,https://doi.org/10.1101/2022.10.22.513328 +V203Q,NP_000537:p.Val203Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.96715,2.124620199203491,2.90442,1.1568037480881284,2.435785,1.5619768740440643,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.63,-,-0.3814,1.1312,-22.2448,-4.648604673011,0.0008900520319589,Benign,0.8935,pathogenic,-3.327,available,https://doi.org/10.1101/2022.10.22.513328 +V203R,NP_000537:p.Val203Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.25514,2.0937530994415283,5.72959,0.749935733055824,4.4923649999999995,2.002537866527912,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.63,-,-0.4308,1.1312,-22.2448,-5.11566355519937,0.0288267796521733,Benign,0.9252,pathogenic,-3.586,available,https://doi.org/10.1101/2022.10.22.513328 +V203S,NP_000537:p.Val203Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.83964,1.826249122619629,2.92143,1.8261669800549525,2.380535,1.8329034900274763,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.63,-,-0.2513,1.1312,-2.7872,-0.756068950576836,5.749610172039073e-08,Benign,0.234,benign,-2.779,available,https://doi.org/10.1101/2022.10.22.513328 +V203T,NP_000537:p.Val203Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.04676,1.147002935409546,1.58639,0.7756361499598552,0.8165749999999999,0.4111980749799276,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.63,-,-0.2659,1.1312,-22.2448,-1.12174146154177,1.3743102891514895e-09,Benign,0.2401,benign,-2.855,available,https://doi.org/10.1101/2022.10.22.513328 +V203W,NP_000537:p.Val203Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,18.79254,1.851479768753052,12.40238,0.41840129664517,15.59746,9.605470648322584,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.63,-,-0.3646,1.1312,-22.2448,-5.11566355519937,0.0159672758446756,Benign,0.9909,pathogenic,-3.673,available,https://doi.org/10.1101/2022.10.22.513328 +V203Y,NP_000537:p.Val203Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,19.80878,1.90755581855774,9.91803,0.7103834246911855,14.863405,10.259581712345593,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.152,,,,,,,,,5.1,,False,5.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.63,-,-0.3675,1.1312,-22.2448,-5.11566355519937,0.0096803345253476,Benign,0.9737,pathogenic,-3.527,available,https://doi.org/10.1101/2022.10.22.513328 +E204A,NP_000537:p.Glu204Ala,"hg19,17:g.7578238T>G, hg38,17:g.7674920T>G",,,0.600,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35414,0.4687522649765014,0.9381,0.3331212613023365,0.64612,0.3436306306511683,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.0,E,-0.1018,1.6413,-8.9541,-4.38455113914571,0.0001680683421586,Benign,0.2159,benign,-3.495,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E204C,NP_000537:p.Glu204Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.16342,-0.0125278234481811,1.42721,0.959809792576644,0.795315,0.5616148962883221,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.0,E,-0.1712,1.6413,-8.9541,-3.42761125374806,0.001161367945352,Benign,0.8336,pathogenic,-3.682,available,https://doi.org/10.1101/2022.10.22.513328 +E204D,NP_000537:p.Glu204Asp,"hg19,17:g.7578237C>A, hg19,17:g.7578237C>G, hg19,17:g.7674919C>G, hg38,17:g.7674919C>G",,,0.494,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3460304,Likely benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.10316,0.9730461835861206,0.36667,0.4653764064309917,0.23491499999999998,0.28426820321549584,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.0,E,-0.0544,1.6413,-6.3692,-1.70479957730539,4.0150175792827125e-06,Benign,0.1919,benign,-3.002,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E204F,NP_000537:p.Glu204Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.63155,0.2847572565078735,0.14286,0.0136920823183334,-0.24434499999999998,-0.30892895884083327,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.0,E,-0.2166,1.6413,-22.2419,-4.31069640536162,3.215117439658388e-05,Benign,0.8283,pathogenic,-3.883,available,https://doi.org/10.1101/2022.10.22.513328 +E204G,NP_000537:p.Glu204Gly,"hg19,17:g.7578238T>C, hg38,17:g.7674920T>C",3.18796225453e-05,,0.604,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",949463,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.0355,1.4508881568908691,2.03231,1.2326599515353536,1.5339049999999999,1.1340799757676767,Uncertain,Neutral,Uncertain,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.0,E,-0.1954,1.6413,-22.2419,-5.25170119144998,0.051540374832763,Benign,0.394,ambiguous,-3.716,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E204H,NP_000537:p.Glu204His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.1307,0.494133710861206,0.88639,0.0229984677803862,0.508545,0.0768492338901931,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.0,E,-0.1283,1.6413,-6.6322,-2.91505188433534,1.0857033450435562e-05,Benign,0.4794,ambiguous,-3.456,available,https://doi.org/10.1101/2022.10.22.513328 +E204I,NP_000537:p.Glu204Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.14553,-0.2139337062835693,-0.00748,-0.0317276100670627,-0.5765049999999999,-0.5886288050335313,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.0,E,-0.1461,1.6413,-7.3692,-2.70082644780406,9.70835372266311e-05,Benign,0.4776,ambiguous,-3.624,available,https://doi.org/10.1101/2022.10.22.513328 +E204K,NP_000537:p.Glu204Lys,"hg38,17:g.7674921C>T",,,0.624,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.30302,0.3082950115203857,0.72755,0.2758346152862828,0.212265,-0.013592692356858616,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.0,E,-0.1062,1.6413,-5.4948,-1.35436664368131,2.2253332968248668e-05,Benign,0.2764,benign,-3.493,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E204L,NP_000537:p.Glu204Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.68247,0.1227993369102478,0.10952,-0.2208052637681384,-0.28647500000000004,-0.4516376318840692,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.0,E,-0.142,1.6413,-6.1468,-2.6742616447969,1.933611226199361e-05,Benign,0.5007,ambiguous,-3.471,available,https://doi.org/10.1101/2022.10.22.513328 +E204M,NP_000537:p.Glu204Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.25282,0.0412167310714721,0.52381,0.0775464785504959,-0.364505,-0.5876367607247521,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.0,E,-0.1051,1.6413,-8.9541,-1.65168695611997,0.00091566086447,Benign,0.512,ambiguous,-3.623,available,https://doi.org/10.1101/2022.10.22.513328 +E204N,NP_000537:p.Glu204Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.0449,0.8382002711296082,1.16327,0.4918511520120133,0.604085,0.26837557600600664,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.0,E,-0.1162,1.6413,-6.6322,-1.7299470999347,0.0001696355237895,Benign,0.3671,ambiguous,-3.438,available,https://doi.org/10.1101/2022.10.22.513328 +E204P,NP_000537:p.Glu204Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.98874,2.772501468658448,2.83061,4.622207066256319,3.409675,4.3054735331281595,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.0,E,-0.3266,1.6413,-22.2419,-6.32700542377472,0.1376994998130876,Benign,0.9601,pathogenic,-3.936,available,https://doi.org/10.1101/2022.10.22.513328 +E204Q,NP_000537:p.Glu204Gln,"hg19,17:g.7578239C>G, hg19,17:g.7674921C>G, hg38,17:g.7674921C>G",,,0.458,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.12603,-0.0192584991455078,-0.31565,0.2291066792308121,-0.22083999999999998,0.05153833961540605,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.0,E,-0.0314,1.6413,-0.5363,-0.625135789158261,4.5104494186125317e-10,Benign,0.1258,benign,-3.088,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E204R,NP_000537:p.Glu204Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.06085,0.3554619550704956,1.07041,0.0384901735282605,0.50478,-0.01117991323586975,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.0,E,-0.1674,1.6413,-5.6323,-2.63740080551945,1.3039883511171566e-07,Benign,0.3603,ambiguous,-3.418,available,https://doi.org/10.1101/2022.10.22.513328 +E204S,NP_000537:p.Glu204Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.51818,0.4819478988647461,1.40578,0.7793320181494251,0.9619800000000001,0.6487560090747125,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.0,E,-0.1102,1.6413,-7.9541,-2.8566033594517,3.05848938498136e-06,Benign,0.2584,benign,-3.378,available,https://doi.org/10.1101/2022.10.22.513328 +E204T,NP_000537:p.Glu204Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.08281,0.0596339702606201,0.50748,0.4569611447804844,0.295145,0.2698855723902422,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,96.0,E,-0.1312,1.6413,-8.9541,-2.57267836171135,0.0001090884621613,Benign,0.2644,benign,-3.426,available,https://doi.org/10.1101/2022.10.22.513328 +E204V,NP_000537:p.Glu204Val,"hg19,17:g.7578238T>A, hg38,17:g.7674920T>A",,,0.588,"COSMIC,ClinVar,saturation_mutlist",1751713,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.30921,-0.2978452444076538,-0.1949,0.0820513187441063,-0.252055,-0.11357934062794683,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.0,E,-0.1007,1.6413,-6.1468,-2.67756988432955,6.02845067582403e-06,Benign,0.3037,benign,-3.386,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E204W,NP_000537:p.Glu204Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.48221,0.3915915489196777,-0.12415,-0.3598839345370092,-0.80318,-0.9210469672685047,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.0,E,-0.2267,1.6413,-22.2419,-2.99371569302676,0.004567682384385,Benign,0.9271,pathogenic,-4.038,available,https://doi.org/10.1101/2022.10.22.513328 +E204Y,NP_000537:p.Glu204Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.59013,0.408906877040863,-0.2381,0.1144272494509757,-0.414115,-0.23785137527451217,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.19,,,Uncertain,,Uncertain,,,Uncertain,62.3,,False,62.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.0,E,-0.1395,1.6413,-6.9542,-2.90435543695547,1.993132469555638e-06,Benign,0.753,pathogenic,-3.61,available,https://doi.org/10.1101/2022.10.22.513328 +Y205A,NP_000537:p.Tyr205Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.61468,3.34375262260437,6.10306,4.292166443146673,5.35887,4.4534232215733365,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.4452,0.0744,-22.239,-7.97634045107894,0.8484287975992963,Pathogenic,0.9987,pathogenic,-4.334,available,https://doi.org/10.1101/2022.10.22.513328 +Y205C,NP_000537:p.Tyr205Cys,"hg19,17:g.7578235T>C, hg19,17:g.7674917T>C, hg38,17:g.7674917T>C",,,0.873,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376681,Pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.92213,2.519715547561645,5.14048,4.468398983016883,4.531305,4.195264491508441,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.4159,0.0744,-22.239,-7.97634045107894,0.4868874191242851,Uncertain,0.9974,pathogenic,-3.948,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y205D,NP_000537:p.Tyr205Asp,"hg19,17:g.7578236A>C, hg19,17:g.7674918A>C, hg38,17:g.7674918A>C",,,0.925,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376686,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.21798,3.304844856262207,6.51735,5.229169617292245,6.367665000000001,5.723574808646122,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.4594,0.0744,-22.239,-7.97634045107894,0.826422286181473,Pathogenic,0.9971,pathogenic,-4.351,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y205E,NP_000537:p.Tyr205Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.39272,3.363075256347656,7.4585,4.843477761018638,6.42561,5.118098880509319,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.4881,0.0744,-22.239,-7.97634045107894,0.8579196539345881,Pathogenic,0.9995,pathogenic,-4.427,available,https://doi.org/10.1101/2022.10.22.513328 +Y205F,NP_000537:p.Tyr205Phe,"hg19,17:g.7578235T>A, hg19,17:g.7674917T>A, hg38,17:g.7674917T>A",,,0.823,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.05106,1.010493278503418,0.44048,0.2262405864013683,0.19471,0.08759029320068415,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,96.57,E,-0.2827,0.0744,-22.239,-3.70658794075006,0.4994217292377448,Uncertain,0.787,pathogenic,-3.521,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y205G,NP_000537:p.Tyr205Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.04869,3.398918628692627,6.81122,5.707136827844665,6.429955,5.877913413922332,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.5158,0.0744,-22.239,-7.97634045107894,0.8528058277747647,Pathogenic,0.9901,pathogenic,-4.416,available,https://doi.org/10.1101/2022.10.22.513328 +Y205H,NP_000537:p.Tyr205His,"hg19,17:g.7578236A>G, hg19,17:g.7674918A>G, hg38,17:g.7674918A>G",,0.0,0.900,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376685,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.27793,1.822041749954224,3.49626,2.824309496852501,2.887095,2.5511197484262507,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.2851,0.0744,-8.9511,-2.98739685309101,0.4831833645818426,Uncertain,0.9986,pathogenic,-3.708,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y205I,NP_000537:p.Tyr205Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.02874,2.8781003952026367,4.19694,3.210480357517154,4.61284,4.1196101787585775,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.3814,0.0744,-7.3663,-4.48512104279824,0.0781555506380318,Benign,0.9917,pathogenic,-3.728,available,https://doi.org/10.1101/2022.10.22.513328 +Y205K,NP_000537:p.Tyr205Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.65376,3.2623329162597656,8.14796,4.903116845589026,5.90086,4.278438422794514,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.5134,0.0744,-22.239,-7.97634045107894,0.8626125582076489,Pathogenic,0.9996,pathogenic,-4.506,available,https://doi.org/10.1101/2022.10.22.513328 +Y205L,NP_000537:p.Tyr205Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.8708,3.0998241901397705,2.61054,2.239451729311845,2.2406699999999997,2.0551258646559223,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.4343,0.0744,-22.239,-7.17417508196052,0.8630548277704961,Pathogenic,0.9799,pathogenic,-4.175,available,https://doi.org/10.1101/2022.10.22.513328 +Y205M,NP_000537:p.Tyr205Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.13332,3.1566872596740723,4.0517,2.6710048923391696,2.5925100000000003,1.902162446169585,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.3865,0.0744,-22.239,-7.17417508196052,0.8346588921503038,Pathogenic,0.9963,pathogenic,-4.366,available,https://doi.org/10.1101/2022.10.22.513328 +Y205N,NP_000537:p.Tyr205Asn,"hg19,17:g.7578236A>T, hg19,17:g.7674918A>T, hg38,17:g.7674918A>T",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376684,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.51587,2.925644636154175,5.05136,4.095761973563877,4.283615,3.8058159867819388,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.4384,0.0744,-22.239,-7.97634045107894,0.8576871658455092,Pathogenic,0.9856,pathogenic,-4.265,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y205P,NP_000537:p.Tyr205Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.00474,3.019184827804565,5.8,7.415258776167963,4.4023699999999995,5.209999388083982,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.5694,0.0744,-22.239,-7.97634045107894,0.8489966387617147,Pathogenic,0.997,pathogenic,-4.426,available,https://doi.org/10.1101/2022.10.22.513328 +Y205Q,NP_000537:p.Tyr205Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.44638,3.3365349769592285,5.58095,4.108757703788337,5.013665,4.277568851894168,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.4629,0.0744,-22.239,-7.97634045107894,0.8706937730778788,Pathogenic,0.9998,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328 +Y205R,NP_000537:p.Tyr205Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.05607,2.915899991989136,7.82177,3.937292875765401,6.9389199999999995,4.9966814378827005,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.5087,0.0744,-22.239,-7.97634045107894,0.8444362660685936,Pathogenic,0.9992,pathogenic,-4.343,available,https://doi.org/10.1101/2022.10.22.513328 +Y205S,NP_000537:p.Tyr205Ser,"hg19,17:g.7578235T>G, hg19,17:g.7674917T>G, hg38,17:g.7674917T>G",,,0.852,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3634430,Uncertain significance,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.64124,3.207209825515747,6.33435,5.1047791234517215,5.987795,5.37300956172586,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.4499,0.0744,-22.239,-7.97634045107894,0.8466488385054057,Pathogenic,0.9955,pathogenic,-4.212,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y205T,NP_000537:p.Tyr205Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.58664,2.967962741851806,6.09966,4.457447014100548,5.34315,4.522043507050274,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.4686,0.0744,-22.239,-7.97634045107894,0.8669915166990285,Pathogenic,0.9982,pathogenic,-4.26,available,https://doi.org/10.1101/2022.10.22.513328 +Y205V,NP_000537:p.Tyr205Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.3499,2.850820302963257,3.68503,3.519823202401396,4.017465,3.934861601200698,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,96.57,E,-0.4468,0.0744,-22.239,-7.17417508196052,0.8244621688231445,Pathogenic,0.9875,pathogenic,-4.217,available,https://doi.org/10.1101/2022.10.22.513328 +Y205W,NP_000537:p.Tyr205Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.99093,0.8453202247619629,2.86327,0.8838019368513061,3.4271000000000003,2.4373659684256532,Uncertain,Uncertain,Neutral,Destabilizing,Uncertain,True,0.23,,,,,,,,,4.8,,True,4.8,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.57,E,-0.3628,0.0744,-22.239,-4.78639668458736,0.8631746615947256,Pathogenic,0.9814,pathogenic,-4.253,available,https://doi.org/10.1101/2022.10.22.513328 +L206A,NP_000537:p.Leu206Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.32317,0.9141727685928344,0.75578,1.199387034553232,1.039475,1.261278517276616,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.27,E,-0.1418,2.226,-7.9541,-2.63845354004875,0.0003864027986074,Benign,0.1294,benign,-3.34,available,https://doi.org/10.1101/2022.10.22.513328 +L206C,NP_000537:p.Leu206Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.92746,-0.026396632194519,1.37449,1.5247714047579224,1.1509749999999999,1.2261157023789613,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.27,E,-0.131,2.226,-7.9541,-2.12599269961508,3.654437724408375e-06,Benign,0.2169,benign,-3.264,available,https://doi.org/10.1101/2022.10.22.513328 +L206D,NP_000537:p.Leu206Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.0046,0.9164569973945618,1.79388,1.176972227062303,1.3992399999999998,1.0907861135311516,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.27,E,-0.3362,2.226,-22.2419,-3.46851593909712,0.0268072779233461,Benign,0.6253,pathogenic,-3.632,available,https://doi.org/10.1101/2022.10.22.513328 +L206E,NP_000537:p.Leu206Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.77817,0.956364929676056,1.00748,0.923935112313038,0.892825,0.851052556156519,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.27,E,-0.2365,2.226,-8.9541,-2.91921010170217,0.0010161061500154,Benign,0.2341,benign,-3.448,available,https://doi.org/10.1101/2022.10.22.513328 +L206F,NP_000537:p.Leu206Phe,"hg19,17:g.7578231C>G, hg38,17:g.7674913C>G",,,0.421,"COSMIC,ClinVar,saturation_mutlist",3972452,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.69564,-0.0061398744583129,0.40442,0.1074170666580481,0.55003,0.40152853332902405,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.27,E,-0.0544,2.226,-3.8667,-0.991137868643407,2.180275711527735e-05,Benign,0.1276,benign,-3.264,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L206G,NP_000537:p.Leu206Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.21696,1.3000308275222778,1.54048,2.001969745200335,1.87872,2.1094648726001672,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.27,E,-0.2895,2.226,-22.2419,-4.04638785210432,0.0191232011836353,Benign,0.4231,ambiguous,-3.534,available,https://doi.org/10.1101/2022.10.22.513328 +L206H,NP_000537:p.Leu206His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.28675,0.3827531933784485,0.35986,0.6062673522000058,0.8233050000000001,0.946508676100003,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.27,E,-0.1704,2.226,-5.2538,-1.9130043991147,4.716631673265454e-06,Benign,0.1235,benign,-3.216,available,https://doi.org/10.1101/2022.10.22.513328 +L206I,NP_000537:p.Leu206Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.18181,-0.6612800359725952,-0.39524,0.0892376738754308,-0.288525,-0.0462861630622846,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.27,E,-0.0057,2.226,-5.9542,-1.33128833739288,3.2085905307627056e-05,Benign,0.0898,benign,-3.146,available,https://doi.org/10.1101/2022.10.22.513328 +L206K,NP_000537:p.Leu206Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.68956,0.4926479458808899,1.10238,0.9650820402792047,0.8959699999999999,0.8273210201396024,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.27,E,-0.2236,2.226,-6.6322,-2.1961200838818,0.000208876334999,Benign,0.2252,benign,-3.438,available,https://doi.org/10.1101/2022.10.22.513328 +L206M,NP_000537:p.Leu206Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.12556,0.3547350764274597,0.3017,0.4501094353835089,0.21363000000000001,0.28783471769175445,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.27,E,-0.0274,2.226,-5.6323,-1.3227862130961,4.299926353001501e-07,Benign,0.0836,benign,-3.132,available,https://doi.org/10.1101/2022.10.22.513328 +L206N,NP_000537:p.Leu206Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.4807,0.5298659801483154,0.90476,1.0670240997397784,1.19273,1.2738620498698892,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.27,E,-0.2825,2.226,-22.2419,-3.10546378898311,0.0197923431339189,Benign,0.3178,benign,-3.554,available,https://doi.org/10.1101/2022.10.22.513328 +L206P,NP_000537:p.Leu206Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.82076,1.7501728534698486,0.80034,4.419710784951987,2.81055,4.620235392475994,Uncertain,Destabilizing,Uncertain,Uncertain,Destabilizing,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.27,E,-0.2303,2.226,-8.9541,-4.94905577644568,0.039911724190222,Benign,0.9462,pathogenic,-3.704,available,https://doi.org/10.1101/2022.10.22.513328 +L206Q,NP_000537:p.Leu206Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.04398,0.7021651268005371,-0.3,0.937876567639924,-0.12800999999999998,0.490928283819962,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.27,E,-0.15,2.226,-5.4948,-2.1184728057432,8.566072079068902e-05,Benign,0.088,benign,-3.176,available,https://doi.org/10.1101/2022.10.22.513328 +L206R,NP_000537:p.Leu206Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.89093,0.5086461305618286,0.52789,0.6691111366907756,0.70941,0.7800205683453878,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.27,E,-0.2109,2.226,-5.7843,-2.22695946322539,0.0002699928533423,Benign,0.1358,benign,-3.367,available,https://doi.org/10.1101/2022.10.22.513328 +L206S,NP_000537:p.Leu206Ser,"hg19,17:g.7578232A>G, hg38,17:g.7674914A>G",,,0.605,"ClinVar,saturation_mutlist",439319,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.63601,0.740720272064209,0.83027,1.5013760046860594,1.23314,1.5686930023430297,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.27,E,-0.162,2.226,-5.9542,-0.883449963984159,6.964653094575099e-05,Benign,0.1231,benign,-3.284,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L206T,NP_000537:p.Leu206Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.2155,0.2984230518341064,0.55816,1.011237463209112,0.88683,1.113368731604556,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.27,E,-0.15,2.226,-8.9541,-2.18011020573432,0.000157397146934,Benign,0.1118,benign,-3.267,available,https://doi.org/10.1101/2022.10.22.513328 +L206V,NP_000537:p.Leu206Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.198,-0.4012246131896972,-0.12415,0.2544637822675166,0.036925000000000006,0.2262318911337583,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.27,E,-0.0163,2.226,-0.9263,-0.433154516033745,1.3973935317773002e-05,Benign,0.0691,benign,-3.021,available,https://doi.org/10.1101/2022.10.22.513328 +L206W,NP_000537:p.Leu206Trp,"hg19,17:g.7578232A>C, hg38,17:g.7674914A>C",,,0.526,"ClinVar,saturation_mutlist",2679229,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.23354,0.4242490530014038,0.2398,-0.0904075979854202,0.73667,0.5715662010072899,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.27,E,-0.1714,2.226,-7.3692,-1.8942896075093,0.0003461990523398,Benign,0.1824,benign,-3.546,available,https://doi.org/10.1101/2022.10.22.513328 +L206Y,NP_000537:p.Leu206Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.45509,0.1739082336425781,-0.15782,0.320276305721795,0.14863500000000002,0.3876831528608975,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.177,,,Uncertain,,Uncertain,,,Uncertain,47.0,,True,47.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.27,E,-0.1592,2.226,-6.3692,-1.88544557925491,0.0001144127208066,Benign,0.2663,benign,-3.464,available,https://doi.org/10.1101/2022.10.22.513328 +D207A,NP_000537:p.Asp207Ala,"hg38,17:g.7674911T>G",,,0.518,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.1202,0.1177909523248672,1.74558,1.297859223437964,1.93289,1.709029611718982,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.47,E,-0.159,1.3244,-8.9541,-4.79992424352891,0.0292428135374466,Benign,0.4022,ambiguous,-3.539,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D207C,NP_000537:p.Asp207Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.28586,-1.2588274478912354,1.34694,1.584760458040503,1.3164,1.4353102290202515,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,94.47,E,-0.2005,1.3244,-8.9541,-4.77078726216089,0.0022373521891778,Benign,0.8244,pathogenic,-3.788,available,https://doi.org/10.1101/2022.10.22.513328 +D207E,NP_000537:p.Asp207Glu,"hg19,17:g.7578228A>C, hg38,17:g.7674910A>C, hg38,17:g.7674910A>T",,,"0.435, 0.436","COSMIC,ClinVar,saturation_mutlist",3809687,Likely benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.10719,-1.0544085502624512,1.13469,1.1145849204775078,1.12094,1.1108874602387537,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,94.47,E,-0.0618,1.3244,-0.7015,-0.414044459748668,1.039597481433019e-08,Benign,0.2799,benign,-2.846,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D207F,NP_000537:p.Asp207Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.7104,-1.828884243965149,0.00306,0.3776714314754742,0.35673,0.5440357157377371,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,94.47,E,-0.327,1.3244,-22.2419,-5.10400276278224,0.0398889079999335,Benign,0.8629,pathogenic,-3.836,available,https://doi.org/10.1101/2022.10.22.513328 +D207G,NP_000537:p.Asp207Gly,"hg19,17:g.7578229T>C, hg38,17:g.7674911T>C",,,0.616,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3972466,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.21069,0.6939965486526489,3.23673,2.426734287504392,2.72371,2.318712143752196,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.47,E,-0.238,1.3244,-22.2419,-4.83904568381669,0.0334052144353968,Benign,0.5033,ambiguous,-3.412,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D207H,NP_000537:p.Asp207His,"hg19,17:g.7578230C>G, hg38,17:g.7674912C>G",,,0.538,"cBioPortal,ClinVar,saturation_mutlist",919639,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.1333,-0.9564467668533324,0.70884,0.6783214624413247,1.42107,1.4058107312206625,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,94.47,E,-0.1684,1.3244,-8.9541,-3.10747195468716,0.0157807360005776,Benign,0.6425,pathogenic,-3.529,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D207I,NP_000537:p.Asp207Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.45609,-1.0201008319854736,0.14388,0.1532753122714653,0.299985,0.30468265613573264,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,94.47,E,-0.2514,1.3244,-8.9541,-4.33749158016168,0.0101649704416947,Benign,0.7299,pathogenic,-3.698,available,https://doi.org/10.1101/2022.10.22.513328 +D207K,NP_000537:p.Asp207Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.47393,-0.6373767256736755,1.01361,1.2694589511011585,1.24377,1.371694475550579,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,94.47,E,-0.2976,1.3244,-22.2419,-4.971732951177,0.0064225936997019,Benign,0.8223,pathogenic,-3.639,available,https://doi.org/10.1101/2022.10.22.513328 +D207L,NP_000537:p.Asp207Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.58057,-1.3345632553100586,-0.03776,-0.0616251378006399,0.271405,0.25947243109968005,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,94.47,E,-0.3129,1.3244,-22.2419,-4.19389362327633,0.0101975091220079,Benign,0.7412,pathogenic,-3.677,available,https://doi.org/10.1101/2022.10.22.513328 +D207M,NP_000537:p.Asp207Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.94047,-1.0305824279785156,0.67109,0.5129772136549123,0.8057799999999999,0.7267236068274562,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,94.47,E,-0.1736,1.3244,-6.9542,-2.75020105792436,0.0002134724885294,Benign,0.849,pathogenic,-3.518,available,https://doi.org/10.1101/2022.10.22.513328 +D207N,NP_000537:p.Asp207Asn,"hg19,17:g.7578230C>T, hg38,17:g.7674912C>T",,,0.406,"cBioPortal,ClinVar,saturation_mutlist",2969522,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.41493,-0.0576035231351852,0.70102,1.0704832246862956,1.0579749999999999,1.2427066123431478,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,94.47,E,-0.1206,1.3244,-7.9541,-0.904858873091193,3.834097103144792e-05,Benign,0.267,benign,-3.22,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D207P,NP_000537:p.Asp207Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.06204,-0.0059200525283813,2.15442,2.5771269566110937,2.10823,2.319583478305547,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,94.47,E,-0.3638,1.3244,-22.2419,-6.07082004462946,0.2655726614104212,Benign,0.9147,pathogenic,-3.805,available,https://doi.org/10.1101/2022.10.22.513328 +D207Q,NP_000537:p.Asp207Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.56877,-0.8863422274589539,0.57347,1.220172984030044,1.07112,1.3944714920150219,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,94.47,E,-0.1809,1.3244,-7.9541,-1.89273746913801,5.514817960445841e-05,Benign,0.637,pathogenic,-3.31,available,https://doi.org/10.1101/2022.10.22.513328 +D207R,NP_000537:p.Asp207Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.08613,-0.6447194218635559,1.22721,0.9526220994825946,1.6566699999999999,1.5193760497412971,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,94.47,E,-0.2608,1.3244,-8.9541,-3.22175504917137,0.0002605374830291,Benign,0.8124,pathogenic,-3.652,available,https://doi.org/10.1101/2022.10.22.513328 +D207S,NP_000537:p.Asp207Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.12441,-0.1344573348760604,1.60612,1.576061132332931,1.865265,1.8502355661664656,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.47,E,-0.1523,1.3244,-6.3692,-2.13296355094089,2.7689885639221726e-06,Benign,0.2727,benign,-3.146,available,https://doi.org/10.1101/2022.10.22.513328 +D207T,NP_000537:p.Asp207Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.53065,-0.6246680021286011,0.67755,1.11925021594101,1.1041,1.324950107970505,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,94.47,E,-0.1874,1.3244,-7.3692,-3.17235150117949,0.0002913022891228,Benign,0.4691,ambiguous,-3.268,available,https://doi.org/10.1101/2022.10.22.513328 +D207V,NP_000537:p.Asp207Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.90212,-0.9723019599914552,0.19728,0.2795886158875021,0.5497000000000001,0.590854307943751,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,94.47,E,-0.201,1.3244,-7.9541,-3.57855740441127,0.0071365951346793,Benign,0.5058,ambiguous,-3.468,available,https://doi.org/10.1101/2022.10.22.513328 +D207W,NP_000537:p.Asp207Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.57545,-1.6191508769989014,0.44218,0.2881956901377952,1.008815,0.9318228450688977,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,94.47,E,-0.3074,1.3244,-22.2419,-5.1609407880589,0.3508762168245638,Uncertain,0.9553,pathogenic,-4.189,available,https://doi.org/10.1101/2022.10.22.513328 +D207Y,NP_000537:p.Asp207Tyr,"hg19,17:g.7674912C>A, hg38,17:g.7674912C>A",,,0.606,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.43731,-1.9136329889297483,0.21054,0.6141910882376724,0.823925,1.0257505441188361,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.054,,,Uncertain,,Uncertain,,,Uncertain,45.1,,True,45.1,,neutral,neutral,neutral,UP,mixed_effects,neutral,False,neutral,neutral,94.47,E,-0.2718,1.3244,-22.2419,-4.88084400394254,0.1053364684538075,Benign,0.5888,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208A,NP_000537:p.Asp208Ala,"hg19,17:g.7578226T>G, hg38,17:g.7674908T>G",,,0.931,"COSMIC,ClinVar,saturation_mutlist",2759300,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.21252,1.962542533874512,2.3915,0.9746952126666322,1.8020100000000001,1.093607606333316,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.3303,0.2005,-22.2419,-5.75119319772927,0.2852018153011107,Benign,0.9084,pathogenic,-3.775,available,https://doi.org/10.1101/2022.10.22.513328 +D208C,NP_000537:p.Asp208Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.80841,0.7578991651535034,2.65816,1.110618254755308,1.733285,0.959514127377654,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.19,-,-0.3717,0.2005,-22.2419,-5.15731424630418,0.0890686896346477,Benign,0.8798,pathogenic,-3.811,available,https://doi.org/10.1101/2022.10.22.513328 +D208E,NP_000537:p.Asp208Glu,"hg19,17:g.7578225G>C, hg19,17:g.7578225G>T, hg38,17:g.7674907G>C, hg38,17:g.7674907G>T",,,0.767,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3972451,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.06504,1.4053199291229248,2.00272,0.6054238781577628,0.96884,0.2701919390788814,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.2752,0.2005,-22.2419,-3.87557754153043,0.0417699064669473,Benign,0.9192,pathogenic,-3.51,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208F,NP_000537:p.Asp208Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.26652,1.4080665111541748,2.51735,-0.1179677279694441,1.125415,-0.19224386398472204,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.4304,0.2005,-22.2419,-7.0826306968347,0.793894066260276,Pathogenic,0.9936,pathogenic,-4.326,available,https://doi.org/10.1101/2022.10.22.513328 +D208G,NP_000537:p.Asp208Gly,"hg19,17:g.7578226T>C, hg19,17:g.7674908T>C, hg38,17:g.7674908T>C",,,0.944,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",584922,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.24517,2.1991076469421387,3.92823,1.7881313342855132,3.0867,2.0166506671427564,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.2736,0.2005,-8.9541,-6.23147236261918,0.1292548314789588,Benign,0.9278,pathogenic,-3.544,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208H,NP_000537:p.Asp208His,"hg19,17:g.7578227C>G, hg38,17:g.7674909C>G",,,0.930,"COSMIC,ClinVar,saturation_mutlist",826261,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.00997,1.0278270244598389,0.55034,0.1001905851863055,0.780155,0.5550802925931527,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.2667,0.2005,-7.9541,-5.09335841444029,0.0276594069680791,Benign,0.9284,pathogenic,-3.554,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208I,NP_000537:p.Asp208Ile,"hg38,17:g.7674908_7674909delinsAT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.19547,1.7489099502563477,1.63197,-0.2330799490003737,0.7182499999999999,-0.21427497450018684,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.4226,0.2005,-22.2419,-7.03768940174965,0.7281322364209232,Pathogenic,0.9852,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208K,NP_000537:p.Asp208Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48379,2.0234408378601074,3.6102,0.6183156913157619,2.046995,0.5510528456578809,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.401,0.2005,-22.2419,-6.7330108051808,0.4219543998764645,Uncertain,0.9897,pathogenic,-3.943,available,https://doi.org/10.1101/2022.10.22.513328 +D208L,NP_000537:p.Asp208Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.52601,1.6760050058364868,1.84966,-0.3150346975402807,0.6618250000000001,-0.42052234877014033,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.4163,0.2005,-22.2419,-7.03768940174965,0.5929163018041799,Uncertain,0.9822,pathogenic,-4.055,available,https://doi.org/10.1101/2022.10.22.513328 +D208M,NP_000537:p.Asp208Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2799,1.7490867376327517,2.18163,0.0614847626307846,0.9508650000000001,-0.10920761868460768,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.355,0.2005,-22.2419,-7.03768940174965,0.6727155892824782,Uncertain,0.9938,pathogenic,-4.174,available,https://doi.org/10.1101/2022.10.22.513328 +D208N,NP_000537:p.Asp208Asn,"hg19,17:g.7578227C>T, hg19,17:g.7674909C>T, hg38,17:g.7674909C>T",,,0.760,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1752332,Likely benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.8419,0.397623062133789,1.0,0.1035982807827801,0.9209499999999999,0.47274914039139004,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.19,-,-0.2189,0.2005,-6.9542,-2.30040921412221,1.853547860211612e-05,Benign,0.5927,pathogenic,-3.313,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208P,NP_000537:p.Asp208Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.7656,2.827207088470459,4.25408,3.881019037617702,3.50984,3.323309518808851,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.19,-,-0.4672,0.2005,-22.2419,-7.87606241147806,0.7448049927605078,Pathogenic,0.9908,pathogenic,-3.944,available,https://doi.org/10.1101/2022.10.22.513328 +D208Q,NP_000537:p.Asp208Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.44165,1.6826595067977903,2.05,0.6109129249358771,1.245825,0.5262814624679386,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.3572,0.2005,-22.2419,-4.52954470710509,0.3541481243655876,Uncertain,0.9775,pathogenic,-3.988,available,https://doi.org/10.1101/2022.10.22.513328 +D208R,NP_000537:p.Asp208Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.02077,1.9842983484268188,3.57075,0.1916003670522836,2.29576,0.6061851835261418,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.432,0.2005,-22.2419,-6.5325523348345,0.3246561183944878,Uncertain,0.9835,pathogenic,-3.881,available,https://doi.org/10.1101/2022.10.22.513328 +D208S,NP_000537:p.Asp208Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.39998,1.4320166110992432,1.58469,1.025437059455015,0.992335,0.7127085297275075,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.2689,0.2005,-8.9541,-5.86478755963323,0.0056821531298285,Benign,0.755,pathogenic,-3.546,available,https://doi.org/10.1101/2022.10.22.513328 +D208T,NP_000537:p.Asp208Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.7994,1.978801965713501,2.65136,0.7358628358972205,2.22538,1.2676314179486103,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.19,-,-0.2908,0.2005,-7.3692,-3.47471301712091,0.0056765997197539,Benign,0.9442,pathogenic,-3.498,available,https://doi.org/10.1101/2022.10.22.513328 +D208V,NP_000537:p.Asp208Val,"hg19,17:g.7578226T>A, hg19,17:g.7674908T>A, hg38,17:g.7674908T>A",,,0.950,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1036023,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.66885,1.776080846786499,1.67075,0.0361530287743394,1.1698,0.3525015143871697,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.3773,0.2005,-22.2419,-6.045583408159,0.7264256741791977,Pathogenic,0.9529,pathogenic,-4.068,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D208W,NP_000537:p.Asp208Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.23479,1.6879868507385254,1.72041,-0.2762594999640699,0.9776,-0.02073474998203495,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.4108,0.2005,-22.2419,-7.0826306968347,0.7834313570062118,Pathogenic,0.998,pathogenic,-4.453,available,https://doi.org/10.1101/2022.10.22.513328 +D208Y,NP_000537:p.Asp208Tyr,"hg19,17:g.7578227C>A, hg38,17:g.7674909C>A",,,0.943,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1350980,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.5405,1.5268101692199707,2.23061,-0.0399538086819828,1.385555,0.25027309565900857,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,55.3,,True,55.3,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.19,-,-0.3752,0.2005,-22.2419,-7.0826306968347,0.7347456192823629,Pathogenic,0.948,pathogenic,-4.178,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R209A,NP_000537:p.Arg209Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.09917,-0.0604428648948669,-0.31565,0.2671754638885609,-0.10824,0.18317273194428044,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.0842,2.6472,-6.1468,-0.475070592540745,1.0567254641788617e-10,Benign,0.1483,benign,-2.885,available,https://doi.org/10.1101/2022.10.22.513328 +R209C,NP_000537:p.Arg209Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.45159,0.0270931720733642,0.31973,0.9869014100025372,0.38566,0.7192457050012686,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.1023,2.6472,-7.9541,-1.21074608663182,1.3730434435277309e-05,Benign,0.1559,benign,-3.136,available,https://doi.org/10.1101/2022.10.22.513328 +R209D,NP_000537:p.Arg209Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.31932,0.3661024570465088,-0.22415,0.1866192661106408,0.047585,0.2529696330553204,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.1707,2.6472,-5.2538,-1.21820925377946,3.5919638424953456e-08,Benign,0.3081,benign,-3.054,available,https://doi.org/10.1101/2022.10.22.513328 +R209E,NP_000537:p.Arg209Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.17878,0.041066825389862,-0.49286,-0.0135816009875794,-0.15704,0.0825991995062103,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.1135,2.6472,-4.7843,-0.462460081260259,1.894627386620856e-13,Benign,0.1404,benign,-2.95,available,https://doi.org/10.1101/2022.10.22.513328 +R209F,NP_000537:p.Arg209Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.1358,0.4260441064834595,0.47313,0.190292328912654,0.304465,0.163046164456327,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.1307,2.6472,-8.9541,-2.64961744699681,0.000503303118731,Benign,0.3972,ambiguous,-3.282,available,https://doi.org/10.1101/2022.10.22.513328 +R209G,NP_000537:p.Arg209Gly,"hg19,17:g.7578224T>C, hg38,17:g.7674906T>C",,,0.635,"COSMIC,ClinVar,saturation_mutlist",627819,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.3379,0.3097323775291443,0.28061,0.7548485883775824,0.309255,0.5463742941887912,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.1169,2.6472,-5.6323,-1.39133951331861,1.0547779696158344e-08,Benign,0.1043,benign,-2.951,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R209H,NP_000537:p.Arg209His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.50825,0.2375476956367492,-0.21803,-0.0371514966596497,0.14511,0.23554925167017515,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.0683,2.6472,-8.9541,-2.03245846017917,1.0898994699904045e-05,Benign,0.1087,benign,-3.032,available,https://doi.org/10.1101/2022.10.22.513328 +R209I,NP_000537:p.Arg209Ile,"hg19,17:g.7578223C>A, hg19,17:g.7674905C>A, hg38,17:g.7674905C>A",,,0.532,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.4601,0.1836844682693481,0.10442,0.1563910028605158,0.28226,0.3082455014302579,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.1198,2.6472,-7.3692,-0.664010578646347,1.2550150352454437e-07,Benign,0.1491,benign,-3.079,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R209K,NP_000537:p.Arg209Lys,"hg19,17:g.7578223C>T, hg19,17:g.7674905C>T, hg38,17:g.7674905C>T",,,0.453,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",962629,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.08447,-0.1276105046272277,-0.41088,0.0105856231248874,-0.16320500000000002,0.0475278115624437,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,90.89,T,0.034,2.6472,-4.4948,-0.10428217322617,4.1594327209504056e-10,Benign,0.0655,benign,-2.795,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R209L,NP_000537:p.Arg209Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.20668,0.2544388771057129,-0.17041,-0.2451100048274462,0.018135,-0.019215002413723092,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.0833,2.6472,-5.4948,-0.965442351395789,1.6286105068538043e-08,Benign,0.1549,benign,-3.004,available,https://doi.org/10.1101/2022.10.22.513328 +R209M,NP_000537:p.Arg209Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.39238,0.185685932636261,0.15238,0.0802342485243351,0.27238,0.23630712426216754,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.0668,2.6472,-8.9541,-0.752997651173962,5.533786452087644e-05,Benign,0.1626,benign,-3.141,available,https://doi.org/10.1101/2022.10.22.513328 +R209N,NP_000537:p.Arg209Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.38034,0.2575557231903076,-0.22993,0.2644887675545188,0.07520500000000001,0.3224143837772594,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.0981,2.6472,-5.9542,-0.979325828733772,7.11659934708321e-07,Benign,0.2598,benign,-2.986,available,https://doi.org/10.1101/2022.10.22.513328 +R209P,NP_000537:p.Arg209Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.41827,-0.3839800357818603,-1.21497,1.8387435292563004,-0.81662,0.7102367646281502,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.2,2.6472,-1.0117,-0.0654921043241854,6.424467143987759e-11,Benign,0.1292,benign,-2.882,available,https://doi.org/10.1101/2022.10.22.513328 +R209Q,NP_000537:p.Arg209Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.34675,-0.1003469228744506,-0.18231,0.2541002530228459,0.08222,0.30042512651142295,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.06,2.6472,-6.3692,-1.2587932454617,4.257629811391549e-07,Benign,0.0751,benign,-2.925,available,https://doi.org/10.1101/2022.10.22.513328 +R209S,NP_000537:p.Arg209Ser,"hg19,17:g.7578222T>A, hg19,17:g.7578222T>G, hg38,17:g.7674904T>A, hg38,17:g.7674904T>G",,,0.588,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2450746,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.25016,-0.0880259871482849,-0.48707,0.2670157610099899,-0.118455,0.2585878805049949,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.069,2.6472,-3.0716,-0.306108475250913,6.543326530673972e-11,Benign,0.1899,benign,-2.817,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R209T,NP_000537:p.Arg209Thr,"hg19,17:g.7578223C>G, hg38,17:g.7674905C>G",,,0.503,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.49965,0.1360905766487121,-0.06803,0.2370217278384678,0.21581,0.3683358639192339,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.0817,2.6472,-4.7063,-0.216224260209177,5.551231848561311e-11,Benign,0.1071,benign,-2.923,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R209V,NP_000537:p.Arg209Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.56094,0.2287198901176452,0.06429,0.2682092487349558,0.312615,0.4145746243674779,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.1032,2.6472,-6.6322,-1.51509444997821,3.295707563919973e-07,Benign,0.1694,benign,-3.081,available,https://doi.org/10.1101/2022.10.22.513328 +R209W,NP_000537:p.Arg209Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.32779,0.4330893158912658,0.60408,-0.2623466437300398,0.465935,0.032721678134980114,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.184,2.6472,-22.2419,-3.00918851809014,0.0569887881782419,Benign,0.1651,benign,-3.498,available,https://doi.org/10.1101/2022.10.22.513328 +R209Y,NP_000537:p.Arg209Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.15138,0.3947834074497223,0.26156,0.2093434809411676,0.20647,0.1803617404705838,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,,,Uncertain,,Uncertain,,,Uncertain,100.7,,True,100.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.89,T,-0.12,2.6472,-8.9541,-2.17427921874393,8.179774195272651e-05,Benign,0.3116,benign,-3.21,available,https://doi.org/10.1101/2022.10.22.513328 +N210A,NP_000537:p.Asn210Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.23123,0.0507888793945312,0.38844,0.1685985763335351,0.30983499999999997,0.19991428816676754,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.0329,2.3513,-6.6352,-2.03279374513134,3.8330661247911836e-07,Benign,0.1591,benign,-3.114,available,https://doi.org/10.1101/2022.10.22.513328 +N210C,NP_000537:p.Asn210Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.46449,-0.3177102208137512,0.84116,0.812510664676411,0.652825,0.6385003323382055,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.1625,2.3513,-22.2448,-3.39086173782156,0.001282364372902,Benign,0.1937,benign,-3.56,available,https://doi.org/10.1101/2022.10.22.513328 +N210D,NP_000537:p.Asn210Asp,"hg38,17:g.7674903T>C",,,0.300,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.20692,0.0467917323112487,-0.05782,0.0070026814039803,-0.13237,-0.09995865929800984,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,90.66,T,-0.048,2.3513,-8.957,-2.49788020409364,7.634782635466312e-06,Benign,0.1612,benign,-3.255,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N210E,NP_000537:p.Asn210Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.23814,-0.2577858567237854,-0.00782,-0.0331377683122102,-0.12297999999999999,-0.1356388841561051,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.1429,2.3513,-22.2448,-2.42513395189994,0.0001253550047578,Benign,0.2682,benign,-3.382,available,https://doi.org/10.1101/2022.10.22.513328 +N210F,NP_000537:p.Asn210Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15266,-0.0151665806770324,-0.23061,-0.1603530639962963,-0.191635,-0.15650653199814815,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.0968,2.3513,-7.957,-2.09942827162007,1.030170708142118e-05,Benign,0.3628,ambiguous,-3.413,available,https://doi.org/10.1101/2022.10.22.513328 +N210G,NP_000537:p.Asn210Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.06159,0.6587672233581543,1.15238,0.6243413305030401,0.545395,0.28137566525152,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.0654,2.3513,-6.9571,-2.44034244424212,1.7109610343255084e-05,Benign,0.2199,benign,-3.214,available,https://doi.org/10.1101/2022.10.22.513328 +N210H,NP_000537:p.Asn210His,"hg19,17:g.7578221T>G, hg38,17:g.7674903T>G",,,0.340,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.04207,-0.0839660167694091,-0.33401,-0.2501706636950906,-0.18803999999999998,-0.1461203318475453,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.0245,2.3513,-4.0029,-0.502012353773146,3.1181353774420475e-08,Benign,0.0826,benign,-3.018,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N210I,NP_000537:p.Asn210Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.27996,-0.1326966881752014,0.28027,-0.0957640056948788,0.00015500000000001624,-0.1878620028474394,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.0555,2.3513,-1.2022,-0.131622522302542,1.7343403076458547e-09,Benign,0.1668,benign,-3.221,available,https://doi.org/10.1101/2022.10.22.513328 +N210K,NP_000537:p.Asn210Lys,"hg38,17:g.7674901G>C",,,0.369,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.49276,0.1318605542182922,-0.15952,-0.0532872420263658,-0.32614,-0.2730236210131829,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.0429,2.3513,-7.957,-2.0116031568231,4.912733405455459e-08,Benign,0.2679,benign,-3.135,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N210L,NP_000537:p.Asn210Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.39833,-0.0189601182937622,-0.15918,-0.3151618752023671,-0.278755,-0.35674593760118356,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.1693,2.3513,-22.2448,-2.02846521268327,0.0018260787952334,Benign,0.1928,benign,-3.393,available,https://doi.org/10.1101/2022.10.22.513328 +N210M,NP_000537:p.Asn210Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.28146,0.040238082408905,0.64694,-0.0141545794671266,0.18273999999999999,-0.1478072897335633,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.0505,2.3513,-7.957,-1.03130203891255,0.0034282432000885,Benign,0.2232,benign,-3.504,available,https://doi.org/10.1101/2022.10.22.513328 +N210P,NP_000537:p.Asn210Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.92744,2.155767679214477,5.01429,3.0734048169685417,2.970865,2.0004224084842708,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,90.66,T,-0.2782,2.3513,-22.2448,-4.60806841115371,0.0136408860526243,Benign,0.5182,ambiguous,-3.587,available,https://doi.org/10.1101/2022.10.22.513328 +N210Q,NP_000537:p.Asn210Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.70163,-0.0910887718200683,0.16735,0.1739396829577955,-0.26714,-0.26384515852110224,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.0183,2.3513,-4.9571,-0.322259744734933,2.693877044529471e-09,Benign,0.1922,benign,-3.05,available,https://doi.org/10.1101/2022.10.22.513328 +N210R,NP_000537:p.Asn210Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.85516,0.052273154258728,0.32143,-0.1976382380373426,-0.266865,-0.5263991190186713,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.0801,2.3513,-8.957,-2.27958977451338,4.216358282451287e-06,Benign,0.2681,benign,-3.292,available,https://doi.org/10.1101/2022.10.22.513328 +N210S,NP_000537:p.Asn210Ser,"hg19,17:g.7578220T>C, hg38,17:g.7674902T>C",,,0.262,"COSMIC,ClinVar,saturation_mutlist",3232058,Likely benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.79221,-0.0227012634277343,-0.22993,0.2916920717769639,-0.51107,-0.25025896411151805,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.0028,2.3513,-6.6352,-1.6835745248611,4.888323316531231e-06,Benign,0.0892,benign,-2.958,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N210T,NP_000537:p.Asn210Thr,"hg38,17:g.7674902T>G",,,0.380,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.56535,-0.2447554469108581,-0.62279,0.1787382409055632,-0.59407,-0.1933058795472184,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,90.66,T,-0.0434,2.3513,-4.8696,-0.692090300639771,6.32499020050508e-12,Benign,0.0949,benign,-2.875,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N210V,NP_000537:p.Asn210Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01385,-0.2829903960227966,0.03299,0.0231078666619755,0.009569999999999999,0.00462893333098775,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.0559,2.3513,-2.5996,-0.215895735946282,2.837682687204054e-09,Benign,0.1558,benign,-3.117,available,https://doi.org/10.1101/2022.10.22.513328 +N210W,NP_000537:p.Asn210Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2453,-0.0521705746650695,0.1949,-0.5144158048336428,-0.0252,-0.3798579024168214,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.1748,2.3513,-22.2448,-3.30555446226139,0.0131709031662775,Benign,0.5747,pathogenic,-3.773,available,https://doi.org/10.1101/2022.10.22.513328 +N210Y,NP_000537:p.Asn210Tyr,"hg19,17:g.7578221T>A, hg38,17:g.7674903T>A",,,0.480,"ClinVar,saturation_mutlist",406588,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.05921,-0.1243795752525329,-0.59014,-0.1212501882375038,-0.324675,-0.09023009411875191,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,,,Uncertain,,Uncertain,,,Uncertain,105.8,,True,105.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,90.66,T,-0.0855,2.3513,-8.957,-2.09316774390548,9.541986785072648e-05,Benign,0.1341,benign,-3.359,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T211A,NP_000537:p.Thr211Ala,"hg19,17:g.7578218T>C, hg19,17:g.7674900T>C, hg38,17:g.7674900T>C",,,0.881,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406581,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.10625,2.436018228530884,1.43095,0.4262109320383639,0.7686,0.26623046601918193,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,DOWN,stabilizing,neutral,False,neutral,neutral,92.07,T,-0.2295,0.2778,-8.957,-3.63665144001085,0.1301048823195264,Benign,0.7434,pathogenic,-3.762,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T211C,NP_000537:p.Thr211Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.54526,1.818599224090576,1.80918,0.9480376800908114,1.17722,0.7466488400454057,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,DOWN,stabilizing,neutral,False,neutral,neutral,92.07,T,-0.3331,0.2778,-22.2448,-4.47471510869345,0.8579282151730939,Pathogenic,0.8913,pathogenic,-4.268,available,https://doi.org/10.1101/2022.10.22.513328 +T211D,NP_000537:p.Thr211Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22883,1.8246976137161253,2.71939,0.4987369552348553,1.47411,0.36378347761742763,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,92.07,T,-0.4128,0.2778,-22.2448,-5.07098938034153,0.2536633758838417,Benign,0.8989,pathogenic,-3.962,available,https://doi.org/10.1101/2022.10.22.513328 +T211E,NP_000537:p.Thr211Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28255,2.422863721847534,1.5449,0.3849359802637359,0.913725,0.3337429901318679,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,92.07,T,-0.3882,0.2778,-22.2448,-5.1916988786315,0.6397260560465343,Uncertain,0.9739,pathogenic,-4.104,available,https://doi.org/10.1101/2022.10.22.513328 +T211F,NP_000537:p.Thr211Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.56886,2.3675432205200195,1.71156,-0.0443536104075176,0.57135,-0.3066068052037588,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,92.07,T,-0.4045,0.2778,-22.2448,-7.44728783945904,0.8514161023670177,Pathogenic,0.9679,pathogenic,-4.411,available,https://doi.org/10.1101/2022.10.22.513328 +T211G,NP_000537:p.Thr211Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.63145,2.442681074142456,2.78571,1.1007280053201656,1.70858,0.8660890026600827,Uncertain,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,DOWN,stabilizing,neutral,False,neutral,neutral,92.07,T,-0.3707,0.2778,-22.2448,-6.26045786165554,0.2953157869212688,Benign,0.6999,pathogenic,-3.956,available,https://doi.org/10.1101/2022.10.22.513328 +T211H,NP_000537:p.Thr211His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.5246,2.030969619750977,2.17177,0.0682529832929845,0.823585,-0.22817350835350772,Uncertain,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,92.07,T,-0.3848,0.2778,-22.2448,-7.44728783945904,0.7972528632017819,Pathogenic,0.8303,pathogenic,-4.263,available,https://doi.org/10.1101/2022.10.22.513328 +T211I,NP_000537:p.Thr211Ile,"hg19,17:g.7578217G>A, hg19,17:g.7674899G>A, hg38,17:g.7674899G>A",,,0.944,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1503185,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.40399,2.4887256622314453,1.75408,0.092943519814051,1.5790350000000002,0.7484667599070255,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,92.07,T,-0.2502,0.2778,-7.957,-4.64531106592155,0.5664694894743243,Uncertain,0.974,pathogenic,-3.921,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T211K,NP_000537:p.Thr211Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.45315,2.539759874343872,1.31395,0.3132100929805081,0.4304,-0.06996995350974594,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,92.07,T,-0.3075,0.2778,-7.957,-6.6999976599105,0.6356356111825094,Uncertain,0.9501,pathogenic,-4.088,available,https://doi.org/10.1101/2022.10.22.513328 +T211L,NP_000537:p.Thr211Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.07096,2.335620403289795,0.53503,-0.2698703887247849,-0.26796499999999995,-0.6704151943623924,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,92.07,T,-0.3073,0.2778,-8.957,-6.80110770447663,0.8346942566966367,Pathogenic,0.825,pathogenic,-4.284,available,https://doi.org/10.1101/2022.10.22.513328 +T211M,NP_000537:p.Thr211Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.95549,2.3902156352996826,0.52687,0.1133010660437566,-0.21431,-0.4210944669781217,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,92.07,T,-0.2742,0.2778,-8.957,-5.06572058813004,0.8621278205364444,Pathogenic,0.8022,pathogenic,-4.136,available,https://doi.org/10.1101/2022.10.22.513328 +T211N,NP_000537:p.Thr211Asn,"hg19,17:g.7578217G>T, hg38,17:g.7674899G>T",,,0.756,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.28259,1.4071208238601685,1.91224,0.2056009702974925,0.8148249999999999,-0.038494514851253755,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,92.07,T,-0.28,0.2778,-7.957,-3.54541722447446,0.0007822012930365,Benign,0.4866,ambiguous,-3.559,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T211P,NP_000537:p.Thr211Pro,"hg19,17:g.7578218T>G, hg38,17:g.7674900T>G",,,0.911,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528235,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42776,2.914624214172364,8.15306,3.5033699292048746,4.79041,2.465564964602437,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,92.07,T,-0.4616,0.2778,-22.2448,-7.44728783945904,0.8541266949452736,Pathogenic,0.8468,pathogenic,-4.228,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T211Q,NP_000537:p.Thr211Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.04522,2.368411064147949,0.98844,0.3817440214473711,0.47161,0.16826201072368555,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,92.07,T,-0.3623,0.2778,-22.2448,-5.68521728352499,0.5987545169213044,Uncertain,0.9286,pathogenic,-4.187,available,https://doi.org/10.1101/2022.10.22.513328 +T211R,NP_000537:p.Thr211Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.26232,2.337648868560791,1.52347,-0.131993180899918,0.6305750000000001,-0.19715659044995898,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,92.07,T,-0.3154,0.2778,-8.957,-7.1973112402619,0.6868979991362969,Pathogenic,0.9114,pathogenic,-4.18,available,https://doi.org/10.1101/2022.10.22.513328 +T211S,NP_000537:p.Thr211Ser,"hg19,17:g.7578217G>C, hg38,17:g.7674899G>C",,,0.753,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1019369,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.06414,0.8584686517715454,1.06429,0.5722593418668215,0.564215,0.3181996709334107,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,neutral,damaging,potentially_damaging,DOWN,stabilizing,neutral,False,neutral,neutral,92.07,T,-0.1813,0.2778,-6.6352,-2.18720541797429,0.0001851706845794,Benign,0.295,benign,-3.296,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T211V,NP_000537:p.Thr211Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.83237,2.25808048248291,1.06735,0.1849225200185467,1.4498600000000001,1.0086462600092734,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,92.07,T,-0.3107,0.2778,-22.2448,-6.80110770447663,0.8055839231342669,Pathogenic,0.9285,pathogenic,-4.154,available,https://doi.org/10.1101/2022.10.22.513328 +T211W,NP_000537:p.Thr211Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.41791,2.2150774002075195,0.9551,-0.5024308393713478,0.6865049999999999,-0.0422604196856739,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,damaging,damaging,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,92.07,T,-0.3974,0.2778,-22.2448,-7.44728783945904,0.8628402744723712,Pathogenic,0.9808,pathogenic,-4.653,available,https://doi.org/10.1101/2022.10.22.513328 +T211Y,NP_000537:p.Thr211Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.22911,2.2037899494171143,1.32381,-0.0406665363063796,0.54735,-0.1348882681531898,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.053,,,Uncertain,,Uncertain,,,Uncertain,29.3,P,True,29.3,4.923,uncertain,damaging,potentially_damaging,UP,mixed_effects,neutral,False,neutral,neutral,92.07,T,-0.406,0.2778,-22.2448,-7.44728783945904,0.858904709167525,Pathogenic,0.9436,pathogenic,-4.476,available,https://doi.org/10.1101/2022.10.22.513328 +F212A,NP_000537:p.Phe212Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.09524,0.5657637119293213,1.93265,1.6839576897013555,1.513945,1.3895988448506778,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.2052,1.9157,-8.9482,-3.49317891176425,0.0076086523547026,Benign,0.537,ambiguous,-3.37,available,https://doi.org/10.1101/2022.10.22.513328 +F212C,NP_000537:p.Phe212Cys,"hg19,17:g.7578214A>C",,,0.647,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.02526,-0.2011462450027465,2.38333,2.128604337315799,1.7042950000000001,1.5769321686578994,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.2412,1.9157,-22.2361,-2.86385680802714,0.0193908215630697,Benign,0.2408,benign,-3.434,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F212D,NP_000537:p.Phe212Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.67396,1.1007994413375854,2.66769,1.7894279258746373,1.670825,1.2316939629373187,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.396,1.9157,-22.2361,-3.96301967086493,0.0025305745381395,Benign,0.7937,pathogenic,-3.337,available,https://doi.org/10.1101/2022.10.22.513328 +F212E,NP_000537:p.Phe212Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.41936,1.342570185661316,2.83061,1.7592554069233246,1.6249850000000001,1.0893077034616623,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.3654,1.9157,-22.2361,-3.46828654794656,0.0001336452853839,Benign,0.8186,pathogenic,-3.232,available,https://doi.org/10.1101/2022.10.22.513328 +F212G,NP_000537:p.Phe212Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.05971,-0.612574577331543,1.4449,2.323653168857156,0.752305,1.191681584428578,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.1989,1.9157,-0.7885,-1.23932658021379,4.6690894306936085e-09,Benign,0.5,ambiguous,-2.984,available,https://doi.org/10.1101/2022.10.22.513328 +F212H,NP_000537:p.Phe212His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.06276,0.0763319730758667,0.98265,0.879171734092132,1.022705,0.9709658670460659,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.2196,1.9157,-6.3634,-1.80709460931218,2.015694296748125e-06,Benign,0.4346,ambiguous,-3.046,available,https://doi.org/10.1101/2022.10.22.513328 +F212I,NP_000537:p.Phe212Ile,"hg19,17:g.7578215A>T, hg38,17:g.7674897A>T",,,0.478,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",422414,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.60653,1.531402349472046,6.53095,1.4476465939483858,4.56874,2.027088296974193,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.2169,1.9157,-22.2361,-4.32079728589621,0.085619917219647,Benign,0.5688,pathogenic,-3.651,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F212K,NP_000537:p.Phe212Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.0898,0.1929077506065368,1.68469,1.2343291162235148,0.8872450000000001,0.6620645581117575,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.2735,1.9157,-2.8823,-1.10700804156014,3.6814305186260638e-09,Benign,0.6899,pathogenic,-3.082,available,https://doi.org/10.1101/2022.10.22.513328 +F212L,NP_000537:p.Phe212Leu,"hg38,17:g.7674895A>T, hg38,17:g.7674897A>G",,,"0.481, 0.489","COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.04352,0.2579991221427917,0.87619,0.620277121227808,0.459855,0.331898560613904,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.0885,1.9157,-4.4889,-1.03107939841147,8.233454131979605e-10,Benign,0.7743,pathogenic,-2.811,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F212M,NP_000537:p.Phe212Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.158,0.2529078125953674,1.31939,0.8915053147066437,0.738695,0.5247526573533219,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.2101,1.9157,-22.2361,-1.43406472192369,0.000145070842239,Benign,0.5365,ambiguous,-3.186,available,https://doi.org/10.1101/2022.10.22.513328 +F212N,NP_000537:p.Phe212Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.44571,0.1913630962371826,1.01088,1.296043502922636,0.728295,0.870876751461318,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.2578,1.9157,-8.9482,-2.54237283675409,8.331946545718333e-06,Benign,0.5446,ambiguous,-3.117,available,https://doi.org/10.1101/2022.10.22.513328 +F212P,NP_000537:p.Phe212Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.58357,1.6031525135040283,4.88163,6.080411721248986,4.7326,5.331990860624493,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.3964,1.9157,-22.2361,-5.67218011770721,0.0833344152654177,Benign,0.9791,pathogenic,-3.692,available,https://doi.org/10.1101/2022.10.22.513328 +F212Q,NP_000537:p.Phe212Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.86463,0.3816491365432739,1.66293,1.4930187982287628,1.2637800000000001,1.1788243991143814,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.248,1.9157,-6.6264,-2.12549553303747,3.4429228118593344e-06,Benign,0.5769,pathogenic,-3.017,available,https://doi.org/10.1101/2022.10.22.513328 +F212R,NP_000537:p.Phe212Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.57578,0.2850175499916076,2.22041,0.9968571235961612,1.398095,0.7863185617980806,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.2905,1.9157,-5.9484,-1.7046024386267,1.6834713372471627e-08,Benign,0.5296,ambiguous,-3.028,available,https://doi.org/10.1101/2022.10.22.513328 +F212S,NP_000537:p.Phe212Ser,"hg19,17:g.7578214A>G, hg38,17:g.7674896A>G",,,0.554,"COSMIC,ClinVar,saturation_mutlist",3460339,Likely benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.50577,0.7798634767532349,2.50646,1.9147483483384653,1.506115,1.2102591741692326,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.1761,1.9157,-7.3634,-2.08927993166533,0.0005328419811119,Benign,0.3508,ambiguous,-3.119,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F212T,NP_000537:p.Phe212Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.5852,1.4457852840423584,3.96701,1.7532784072817025,3.2761050000000003,2.169239203640851,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.2305,1.9157,-8.9482,-3.71022864896652,0.0004472734518521,Benign,0.6653,pathogenic,-3.168,available,https://doi.org/10.1101/2022.10.22.513328 +F212V,NP_000537:p.Phe212Val,"hg19,17:g.7578215A>C, hg38,17:g.7674897A>C",,,0.471,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.90545,1.5694444179534912,6.13163,1.417301327562765,4.51854,2.1613756637813824,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,93.48,-,-0.2113,1.9157,-22.2361,-4.32079728589621,0.1492406082977196,Benign,0.4369,ambiguous,-3.471,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F212W,NP_000537:p.Phe212Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.29436,0.3581351637840271,0.42959,0.1898367173939852,0.36197500000000005,0.2420983586969926,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.48,-,-0.1287,1.9157,-8.9482,-3.83745532613329,0.0605611702082683,Benign,0.501,ambiguous,-3.66,available,https://doi.org/10.1101/2022.10.22.513328 +F212Y,NP_000537:p.Phe212Tyr,"hg19,17:g.7578214A>T, hg38,17:g.7674896A>T",,,0.395,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.1421,0.3388146758079529,0.18912,0.3778994505737981,0.16561,0.2599997252868991,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,Uncertain,,Uncertain,,,Uncertain,53.8,,True,53.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.48,-,-0.0852,1.9157,-6.6264,-1.08294441578119,0.0147571010942062,Benign,0.135,benign,-3.244,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R213A,NP_000537:p.Arg213Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.54577,1.391567349433899,1.16259,2.232929529564247,1.85418,2.3893497647821236,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.3382,0.0421,-8.9482,-7.76858168299495,0.8708290226341315,Pathogenic,0.9985,pathogenic,-4.15,available,https://doi.org/10.1101/2022.10.22.513328 +R213C,NP_000537:p.Arg213Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.27541,0.9488964676856996,0.97619,2.489836459569237,1.6258,2.3826232297846186,Uncertain,Uncertain,Neutral,Neutral,Uncertain,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.4148,0.0421,-22.2361,-7.76858168299495,0.8052714141874626,Pathogenic,0.9587,pathogenic,-4.16,available,https://doi.org/10.1101/2022.10.22.513328 +R213D,NP_000537:p.Arg213Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.26981,2.157133817672729,2.55884,3.1708158491976395,3.414325,3.7203129245988196,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.497,0.0421,-22.2361,-7.41214458829591,0.8708564673846064,Pathogenic,0.9993,pathogenic,-4.44,available,https://doi.org/10.1101/2022.10.22.513328 +R213E,NP_000537:p.Arg213Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.79746,1.636466145515442,2.19966,2.463935683801618,2.4985600000000003,2.630697841900809,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.4423,0.0421,-22.2361,-7.41214458829591,0.8437713597719634,Pathogenic,0.995,pathogenic,-4.419,available,https://doi.org/10.1101/2022.10.22.513328 +R213F,NP_000537:p.Arg213Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.33619,0.7744045257568359,-1.41939,-0.1466530073959659,-0.87779,-0.24142150369798293,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.39,-,-0.4381,0.0421,-22.2361,-6.5936364022848,0.8368836775222191,Pathogenic,0.9979,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +R213G,NP_000537:p.Arg213Gly,"hg19,17:g.7578212G>C, hg19,17:g.7674894G>C, hg38,17:g.7674894G>C",,,0.915,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376651,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.33688,1.8835394382476809,3.08776,3.858495750413727,3.21232,3.5976878752068635,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.4413,0.0421,-22.2361,-8.03821593623277,0.865520093238438,Pathogenic,0.9955,pathogenic,-4.295,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R213H,NP_000537:p.Arg213His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.3774,1.0903708934783936,0.16701,1.4842641899672826,1.272205,1.9308320949836415,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.3757,0.0421,-22.2361,-5.86502111570081,0.186923686155542,Benign,0.9273,pathogenic,-3.62,available,https://doi.org/10.1101/2022.10.22.513328 +R213I,NP_000537:p.Arg213Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.62465,0.9198270440101624,-0.58912,0.5314167421298934,0.01776500000000003,0.5780333710649468,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.4354,0.0421,-22.2361,-8.03821593623277,0.7920865083920613,Pathogenic,0.9971,pathogenic,-4.309,available,https://doi.org/10.1101/2022.10.22.513328 +R213K,NP_000537:p.Arg213Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.67193,0.5390770435333252,2.22449,2.456033626833116,1.94821,2.063981813416558,Uncertain,Uncertain,Neutral,Neutral,Uncertain,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.39,-,-0.2962,0.0421,-22.2361,-4.82659765217877,0.821986333859194,Pathogenic,0.9783,pathogenic,-3.972,available,https://doi.org/10.1101/2022.10.22.513328 +R213L,NP_000537:p.Arg213Leu,"hg19,17:g.7578211C>A, hg19,17:g.7674892_7674893delinsCA, hg19,17:g.7674893C>A, hg38,17:g.7674892_7674893delinsCA, hg38,17:g.7674893C>A",,,0.929,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376650,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.17316,0.3313243389129638,-1.13027,-0.173640326373195,-0.47855500000000006,-0.00024016318659748903,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.4084,0.0421,-22.2361,-8.03821593623277,0.8609277176067004,Pathogenic,0.9906,pathogenic,-4.104,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R213M,NP_000537:p.Arg213Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01549,0.4893178939819336,-0.93367,0.739211950203363,-0.45909,0.37735097510168153,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.3743,0.0421,-22.2361,-8.03821593623277,0.7771634233961031,Pathogenic,0.9991,pathogenic,-4.084,available,https://doi.org/10.1101/2022.10.22.513328 +R213N,NP_000537:p.Arg213Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.99206,1.5589172840118408,1.28095,2.310736744368721,2.136505,2.65139837218436,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.4209,0.0421,-22.2361,-7.41214458829591,0.774929671814917,Pathogenic,0.9986,pathogenic,-4.085,available,https://doi.org/10.1101/2022.10.22.513328 +R213P,NP_000537:p.Arg213Pro,"hg19,17:g.7578211C>G, hg19,17:g.7674893C>G, hg38,17:g.7674893C>G",,,0.951,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",231214,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.97378,2.7707173824310303,7.33469,7.292964263135091,7.654235,7.633372131567546,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.5481,0.0421,-22.2361,-8.03821593623277,0.8630471616007978,Pathogenic,0.9986,pathogenic,-4.34,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R213Q,NP_000537:p.Arg213Gln,"hg19,17:g.7578210_7578211delinsCT, hg19,17:g.7578211C>T, hg19,17:g.7674893C>T, hg38,17:g.7674892_7674893delinsCT, hg38,17:g.7674893C>T",,3.9767440011e-06,0.920,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",135359,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.6724,0.925859808921814,1.25918,2.0824437936953144,1.4657900000000001,1.8774218968476573,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.3129,0.0421,-8.9482,-5.48929031422363,0.8249162635632338,Pathogenic,0.9561,pathogenic,-3.827,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R213S,NP_000537:p.Arg213Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.43096,1.819615721702576,1.52211,2.974670491499124,2.476535,3.2028152457495622,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.4065,0.0421,-22.2361,-7.76858168299495,0.8700925024565056,Pathogenic,0.9984,pathogenic,-4.16,available,https://doi.org/10.1101/2022.10.22.513328 +R213T,NP_000537:p.Arg213Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.21042,1.5482772588729858,0.21735,1.93834221380136,1.713885,2.57438110690068,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.4109,0.0421,-22.2361,-7.76858168299495,0.8475534069526093,Pathogenic,0.9986,pathogenic,-4.182,available,https://doi.org/10.1101/2022.10.22.513328 +R213V,NP_000537:p.Arg213Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42047,1.1427099704742432,0.01667,1.0269510588147457,0.7185699999999999,1.2237105294073727,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,95.39,-,-0.4225,0.0421,-22.2361,-8.03821593623277,0.8705599875957521,Pathogenic,0.9976,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +R213W,NP_000537:p.Arg213Trp,"hg19,17:g.7578210_7578212delinsCCA, hg38,17:g.7674892_7674894delinsCCA",,,,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3460335,Pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.17438,0.7802315354347229,0.02313,0.1053055199887526,2.598755,2.6398427599943766,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.39,-,-0.4237,0.0421,-22.2361,-6.5936364022848,0.8394075372421022,Pathogenic,0.9479,pathogenic,-4.152,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R213Y,NP_000537:p.Arg213Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.95312,0.7661279439926147,-1.24388,0.3416594113983101,-0.14538000000000006,0.647389705699155,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.078,,,,,,,,,2.8,,True,2.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.39,-,-0.4274,0.0421,-22.2361,-6.5936364022848,0.7928861798017692,Pathogenic,0.992,pathogenic,-4.208,available,https://doi.org/10.1101/2022.10.22.513328 +H214A,NP_000537:p.His214Ala,,,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.15337,1.2685489654541016,1.22007,1.5208877623717043,0.68672,0.8371288811858522,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.54,E,-0.2125,0.9192,-22.2419,-5.55656608914318,0.8341463212690233,Pathogenic,0.9728,pathogenic,-4.178,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214C,NP_000537:p.His214Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.0245,0.3615871071815491,0.63401,1.8887615111493865,0.304755,0.9321307555746933,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.54,E,-0.267,0.9192,-22.2419,-5.24335004222305,0.3454336796092247,Uncertain,0.7867,pathogenic,-3.956,available,https://doi.org/10.1101/2022.10.22.513328 +H214D,NP_000537:p.His214Asp,"hg19,17:g.7578209G>C, hg38,17:g.7674891G>C",,,0.844,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.22183,1.756016492843628,2.69082,2.196845966331499,1.956325,1.7093379831657494,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.54,E,-0.2597,0.9192,-22.2419,-3.52139071132981,0.8580051769914587,Pathogenic,0.9861,pathogenic,-4.161,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214E,NP_000537:p.His214Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.78615,1.296142578125,2.46565,1.5079543417167662,1.6259000000000001,1.1470521708583832,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.54,E,-0.2712,0.9192,-22.2419,-2.67614011798552,0.264674153989896,Benign,0.964,pathogenic,-3.795,available,https://doi.org/10.1101/2022.10.22.513328 +H214F,NP_000537:p.His214Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.44718,0.1066452264785766,-0.93401,0.4138796366582292,-0.243415,0.43052981832911463,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.54,E,-0.2341,0.9192,-22.2419,-3.84006568735445,0.4250087933533695,Uncertain,0.9313,pathogenic,-4.078,available,https://doi.org/10.1101/2022.10.22.513328 +H214G,NP_000537:p.His214Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.20877,1.7722892761230469,2.65374,2.5605236955419564,1.931255,1.8846468477709781,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.54,E,-0.2951,0.9192,-22.2419,-6.13903125739984,0.7798925193016145,Pathogenic,0.9787,pathogenic,-4.209,available,https://doi.org/10.1101/2022.10.22.513328 +H214I,NP_000537:p.His214Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.15433,0.8129429221153259,-0.9551,0.7758462487221232,-1.054715,-0.18924187563893846,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.54,E,-0.2987,0.9192,-22.2419,-4.70255455261732,0.8602060636819979,Pathogenic,0.9923,pathogenic,-4.232,available,https://doi.org/10.1101/2022.10.22.513328 +H214K,NP_000537:p.His214Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.21903,0.7871322631835938,1.95646,1.5158176111548582,1.587745,1.3674238055774293,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.54,E,-0.1876,0.9192,-8.9541,-3.56992154150808,0.2176804642261617,Benign,0.9667,pathogenic,-3.858,available,https://doi.org/10.1101/2022.10.22.513328 +H214L,NP_000537:p.His214Leu,"hg19,17:g.7578208T>A, hg38,17:g.7674890T>A",,,0.869,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376616,Likely pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.71677,0.377217948436737,-1.3119,0.4084042479088151,-1.014335,-0.15418287604559247,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.54,E,-0.2623,0.9192,-22.2419,-3.80100244388362,0.0995391524206491,Benign,0.8,pathogenic,-3.753,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214M,NP_000537:p.His214Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.01935,0.5091555118560791,-0.70306,0.9740682515845512,-0.861205,-0.02264087420772437,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.54,E,-0.2124,0.9192,-22.2419,-3.87460467270577,0.1576713376386322,Benign,0.959,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328 +H214N,NP_000537:p.His214Asn,"hg19,17:g.7578209G>T, hg38,17:g.7674891G>T",,,0.735,"ClinVar,saturation_mutlist",230254,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.29766,0.7893964648246765,1.10578,1.5103733702272522,0.40406,0.6063566851136261,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.54,E,-0.2192,0.9192,-22.2419,-3.29554812010733,0.722255729522221,Pathogenic,0.8346,pathogenic,-3.844,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214P,NP_000537:p.His214Pro,"hg19,17:g.7578208T>G, hg38,17:g.7674890T>G",,0.0,0.932,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",643078,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.24617,0.2489293813705444,2.4568,3.757977250794109,0.6053149999999999,1.2559036253970546,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.54,E,-0.3757,0.9192,-22.2419,-6.13903125739984,0.8301338606677469,Pathogenic,0.9774,pathogenic,-4.11,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214Q,NP_000537:p.His214Gln,"hg19,17:g.7578207A>C, hg38,17:g.7674889A>C, hg38,17:g.7674889A>T",,3.18134459529e-05,0.550,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",140943,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.69375,0.8495200276374817,0.7568,1.3358918007771114,0.031525000000000025,0.32107090038855574,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.54,E,-0.0699,0.9192,-0.5196,-0.0842496993920413,6.364507416884325e-07,Benign,0.7704,pathogenic,-2.996,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214R,NP_000537:p.His214Arg,"hg19,17:g.7578208T>C, hg19,17:g.7674890T>C, hg38,17:g.7674890T>C",,,0.885,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376615,Pathogenic,3,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.79783,0.6885324120521545,1.54116,1.0866441068955994,2.169495,1.9422370534477995,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.54,E,-0.2488,0.9192,-22.2419,-4.8374880537707,0.3910010095839695,Uncertain,0.9451,pathogenic,-3.856,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H214S,NP_000537:p.His214Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.19203,1.2441508769989014,1.54116,1.879869819010932,0.866595,1.035949909505466,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.54,E,-0.2184,0.9192,-22.2419,-5.55656608914318,0.8660162688848886,Pathogenic,0.9557,pathogenic,-3.984,available,https://doi.org/10.1101/2022.10.22.513328 +H214T,NP_000537:p.His214Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.05394,1.2540165185928345,1.42041,1.5209504626757648,0.737175,0.7874452313378825,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.54,E,-0.1955,0.9192,-8.9541,-5.55656608914318,0.8622893384076964,Pathogenic,0.9916,pathogenic,-4.116,available,https://doi.org/10.1101/2022.10.22.513328 +H214V,NP_000537:p.His214Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.51151,1.0678666830062866,-0.05136,0.99865080996732,-0.781435,-0.25642959501633994,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.54,E,-0.2551,0.9192,-22.2419,-4.70255455261732,0.8672932129288928,Pathogenic,0.9893,pathogenic,-4.203,available,https://doi.org/10.1101/2022.10.22.513328 +H214W,NP_000537:p.His214Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.64452,-0.2329157590866089,0.01769,0.2382841771602423,2.831105,2.941402088580121,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.54,E,-0.2504,0.9192,-22.2419,-4.03349708167166,0.8544198015878388,Pathogenic,0.948,pathogenic,-4.488,available,https://doi.org/10.1101/2022.10.22.513328 +H214Y,NP_000537:p.His214Tyr,"hg19,17:g.7578209G>A, hg19,17:g.7578209_7578210inv, hg38,17:g.7674891G>A, hg38,17:g.7674891_7674892inv",,,0.736,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","4530422, 1053808",Uncertain significance,3,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,-0.67225,-0.4408925771713257,-0.71122,0.7146637758277155,-0.691735,0.02120688791385772,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.166,,,,,,,,,8.9,,True,8.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.54,E,-0.1843,0.9192,-22.2419,-3.64208286680964,0.2021462130735969,Benign,0.8018,pathogenic,-3.735,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215A,NP_000537:p.Ser215Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.46287,0.4068685173988342,-0.21769,-0.3178130137769785,0.12259,0.07252849311151074,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,damaging,uncertain,-,uncertain,neutral,False,neutral,neutral,97.45,E,-0.2731,0.0798,-22.2419,-4.73329170270735,0.7902628822701911,Pathogenic,0.6135,pathogenic,-3.662,available,https://doi.org/10.1101/2022.10.22.513328 +S215C,NP_000537:p.Ser215Cys,"hg19,17:g.7578206T>A, hg19,17:g.7674888T>A, hg38,17:g.7674888T>A",,,0.902,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1753522,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.08776,-0.1523209810256958,-0.1932,0.3876023224369745,-0.05272,0.23768116121848726,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.2558,0.0798,-8.9541,-2.10381058388002,0.1022355126315968,Benign,0.4744,ambiguous,-3.564,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215D,NP_000537:p.Ser215Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.21694,2.29141902923584,0.62177,0.7088191515158306,1.9193550000000001,1.9628795757579154,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.3718,0.0798,-22.2419,-6.85173328607324,0.8670775833252734,Pathogenic,0.9952,pathogenic,-4.486,available,https://doi.org/10.1101/2022.10.22.513328 +S215E,NP_000537:p.Ser215Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.68861,1.3095462322235107,1.32007,0.376397752998388,2.00434,1.532503876499194,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,uncertain,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.345,0.0798,-22.2419,-5.87476269690066,0.8527333454847852,Pathogenic,0.9949,pathogenic,-4.413,available,https://doi.org/10.1101/2022.10.22.513328 +S215F,NP_000537:p.Ser215Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.69485,-0.2561547756195068,-0.84558,-0.7482428993699008,2.424635,2.4733035503150496,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.3512,0.0798,-22.2419,-6.55283609753433,0.4609662213966627,Uncertain,0.9772,pathogenic,-4.029,available,https://doi.org/10.1101/2022.10.22.513328 +S215G,NP_000537:p.Ser215Gly,"hg19,17:g.7578206T>C, hg19,17:g.7674888T>C, hg38,17:g.7674888T>C",,,0.896,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",265337,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.99865,1.66558837890625,1.82517,1.1157933094093793,1.91191,1.5572216547046898,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,damaging,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,E,-0.2823,0.0798,-22.2419,-7.88480027678971,0.8708084160401148,Pathogenic,0.8417,pathogenic,-4.104,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215H,NP_000537:p.Ser215His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.94666,0.8758505582809448,0.02789,-0.3870315424303772,1.4872750000000001,1.2798142287848115,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,uncertain,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.3524,0.0798,-22.2419,-6.97005118812259,0.8684153550947646,Pathogenic,0.9567,pathogenic,-4.355,available,https://doi.org/10.1101/2022.10.22.513328 +S215I,NP_000537:p.Ser215Ile,"hg19,17:g.7578205C>A, hg19,17:g.7674887C>A, hg38,17:g.7674887C>A",,,0.913,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376660,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.88411,-0.1516486406326294,0.37109,-0.2380375426093273,0.6275999999999999,0.3230362286953363,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.3543,0.0798,-22.2419,-7.35595670390969,0.868254689160872,Pathogenic,0.984,pathogenic,-4.408,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215K,NP_000537:p.Ser215Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.24792,1.3908883333206177,1.03503,0.5152147653222552,1.1414749999999998,0.8815673826611276,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.3618,0.0798,-22.2419,-7.88480027678971,0.8702193250299106,Pathogenic,0.9993,pathogenic,-4.554,available,https://doi.org/10.1101/2022.10.22.513328 +S215L,NP_000537:p.Ser215Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.29632,0.5549768209457397,0.39014,-0.9220903998195028,0.8432299999999999,0.18711480009024856,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.3506,0.0798,-22.2419,-7.35595670390969,0.8707605326470282,Pathogenic,0.9553,pathogenic,-4.37,available,https://doi.org/10.1101/2022.10.22.513328 +S215M,NP_000537:p.Ser215Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.37402,0.2053384780883789,-0.11054,-0.6976636788380502,-0.24228,-0.5358418394190252,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.2487,0.0798,-7.9541,-5.23075562451699,0.8044155618922085,Pathogenic,0.9306,pathogenic,-4.192,available,https://doi.org/10.1101/2022.10.22.513328 +S215N,NP_000537:p.Ser215Asn,"hg19,17:g.7578205C>T, hg19,17:g.7674887C>T, hg38,17:g.7674887C>T",,,0.785,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376662,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,2.24829,1.7092382907867432,0.1534,0.0992574928354489,1.200845,1.1737737464177245,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,uncertain,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.2955,0.0798,-22.2419,-5.85983530296452,0.5302654752351877,Uncertain,0.9616,pathogenic,-3.858,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215P,NP_000537:p.Ser215Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.9737,2.8631324768066406,2.63946,5.431855616181673,3.8065800000000003,5.202777808090836,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.3588,0.0798,-8.9541,-7.88480027678971,0.857492124739714,Pathogenic,0.9993,pathogenic,-4.414,available,https://doi.org/10.1101/2022.10.22.513328 +S215Q,NP_000537:p.Ser215Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.06219,1.1256260871887207,0.9102,-0.1153163760443076,2.486195,1.9734368119778463,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.3151,0.0798,-22.2419,-6.85173328607324,0.8604222736812217,Pathogenic,0.9858,pathogenic,-4.409,available,https://doi.org/10.1101/2022.10.22.513328 +S215R,NP_000537:p.Ser215Arg,"hg19,17:g.7578204A>C, hg19,17:g.7578204A>T, hg19,17:g.7578206T>G, hg19,17:g.7674886A>C, hg19,17:g.7674886A>T, hg19,17:g.7674888T>G, hg38,17:g.7674886A>C, hg38,17:g.7674886A>T, hg38,17:g.7674888T>G",,,"0.812, 0.917","cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","2020649, 428895, 376661","Conflicting classifications of pathogenicity, Conflicting classifications of pathogenicity, Conflicting classifications of pathogenicity","1, 1, 1",Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.3231,1.1241947412490845,1.75136,-0.0361531188305486,2.03723,1.1434734405847258,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,uncertain,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.367,0.0798,-22.2419,-7.88480027678971,0.8702514428238202,Pathogenic,0.998,pathogenic,-4.477,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215T,NP_000537:p.Ser215Thr,"hg19,17:g.7578205C>G, hg19,17:g.7674887C>G, hg38,17:g.7674887C>G",,,0.852,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142012,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.43477,0.0568171739578247,0.3017,0.1489756160787647,0.368235,0.2918728080393823,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,neutral,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.2638,0.0798,-22.2419,-4.73329170270735,0.6045646846032936,Uncertain,0.7415,pathogenic,-3.929,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S215V,NP_000537:p.Ser215Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.54894,-0.108862280845642,-0.00646,-0.2173023875647178,0.27124,0.16581880621764108,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.3286,0.0798,-22.2419,-7.35595670390969,0.8570647858427285,Pathogenic,0.9623,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +S215W,NP_000537:p.Ser215Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.67229,-0.0940964221954345,0.89116,-1.069730412546516,2.7817250000000002,1.8012797937267422,Uncertain,Uncertain,Neutral,Uncertain,Neutral,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.3609,0.0798,-22.2419,-6.97005118812259,0.869837277193661,Pathogenic,0.9678,pathogenic,-4.558,available,https://doi.org/10.1101/2022.10.22.513328 +S215Y,NP_000537:p.Ser215Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.94012,-0.0988696813583374,-0.58163,-0.5130833381888922,2.6792450000000003,2.713518330905554,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,True,0.366,,,,,,,,,6.5,P,True,6.5,4.516,uncertain,neutral,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,E,-0.356,0.0798,-22.2419,-6.68768948551046,0.6885310238208447,Pathogenic,0.9626,pathogenic,-4.065,available,https://doi.org/10.1101/2022.10.22.513328 +V216A,NP_000537:p.Val216Ala,"hg38,17:g.7674884A>G",,,0.961,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.0873,1.95844566822052,2.41429,2.7728183438849068,2.750795,2.930059171942453,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.61,E,-0.3456,0.0589,-22.2419,-4.6325659282855,0.2121431528149867,Benign,0.7484,pathogenic,-3.817,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V216C,NP_000537:p.Val216Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.37022,1.5090432167053225,2.01871,2.56080570548304,2.194465,2.4655128527415204,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.61,E,-0.3005,0.0589,-7.9541,-3.87135867681977,0.590414489585029,Uncertain,0.9298,pathogenic,-3.996,available,https://doi.org/10.1101/2022.10.22.513328 +V216D,NP_000537:p.Val216Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.56644,2.9671084880828857,4.33163,4.204522053614179,4.449035,4.385481026807089,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.61,E,-0.5122,0.0589,-22.2419,-7.86367800860004,0.8631213537277933,Pathogenic,0.9994,pathogenic,-4.671,available,https://doi.org/10.1101/2022.10.22.513328 +V216E,NP_000537:p.Val216Glu,"hg19,17:g.7578202A>T, hg19,17:g.7674884A>T, hg38,17:g.7674884A>T",,,0.982,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376672,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.87138,3.0683367252349854,4.80374,4.005748034871798,5.83756,5.438564017435899,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.61,E,-0.4695,0.0589,-22.2419,-7.86367800860004,0.8686101236222001,Pathogenic,0.9979,pathogenic,-4.568,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V216F,NP_000537:p.Val216Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.57838,2.030608892440796,5.20238,2.6028955193830865,7.8903799999999995,6.590637759691543,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.61,E,-0.4227,0.0589,-22.2419,-7.86367800860004,0.8311410281596893,Pathogenic,0.9916,pathogenic,-4.143,available,https://doi.org/10.1101/2022.10.22.513328 +V216G,NP_000537:p.Val216Gly,"hg19,17:g.7578202A>C, hg19,17:g.7674884A>C, hg38,17:g.7674884A>C",,,0.980,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376671,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.92566,3.0117194652557373,4.93061,4.838704170753297,4.928134999999999,4.882182085376648,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.61,E,-0.4714,0.0589,-22.2419,-7.86367800860004,0.8256892002552828,Pathogenic,0.9564,pathogenic,-4.552,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V216H,NP_000537:p.Val216His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.8423,2.997562885284424,6.01224,3.3454029823454565,8.42727,7.093851491172728,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.61,E,-0.5151,0.0589,-22.2419,-7.86367800860004,0.8696118076235965,Pathogenic,0.9995,pathogenic,-4.55,available,https://doi.org/10.1101/2022.10.22.513328 +V216I,NP_000537:p.Val216Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.08566,0.955274224281311,0.77653,0.427164475472499,1.431095,1.2564122377362494,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.61,E,-0.2811,0.0589,-22.2419,-3.79034313394866,0.148946011181657,Benign,0.2941,benign,-3.402,available,https://doi.org/10.1101/2022.10.22.513328 +V216K,NP_000537:p.Val216Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.47677,3.1097412109375,7.33776,5.364984438927731,8.407265,7.420877219463866,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.61,E,-0.5084,0.0589,-22.2419,-7.86367800860004,0.8661180589912671,Pathogenic,0.9986,pathogenic,-4.689,available,https://doi.org/10.1101/2022.10.22.513328 +V216L,NP_000537:p.Val216Leu,"hg19,17:g.7578203C>A, hg19,17:g.7578203C>G, hg19,17:g.7674885C>A, hg38,17:g.7674885C>A, hg38,17:g.7674885C>G",,,0.948,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","406596, 376670","Conflicting classifications of pathogenicity, Conflicting classifications of pathogenicity","1, 1",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.21855,1.7111655473709106,0.79184,1.0382978850018656,1.505195,1.6284239425009328,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.61,E,-0.3462,0.0589,-22.2419,-3.74686827650794,0.1379060289651364,Benign,0.9153,pathogenic,-3.549,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V216M,NP_000537:p.Val216Met,"hg19,17:g.7578203C>T, hg19,17:g.7674885C>T, hg38,17:g.7674885C>T",,,0.956,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182965,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.26358,2.250279188156128,2.29422,1.933752098640337,2.2789,2.0986660493201685,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.61,E,-0.3553,0.0589,-22.2419,-4.72138030490248,0.8674075800808352,Pathogenic,0.9421,pathogenic,-4.043,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V216N,NP_000537:p.Val216Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.78123,3.1702730655670166,3.15748,2.884831807826081,3.469355,3.3330309039130404,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.61,E,-0.5,0.0589,-22.2419,-7.86367800860004,0.8674033412184625,Pathogenic,0.9972,pathogenic,-4.521,available,https://doi.org/10.1101/2022.10.22.513328 +V216P,NP_000537:p.Val216Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.19322,2.467214584350586,4.21565,6.162410893717071,4.204435,5.177815446858536,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.61,E,-0.5499,0.0589,-22.2419,-7.86367800860004,0.8565058783001898,Pathogenic,0.998,pathogenic,-4.524,available,https://doi.org/10.1101/2022.10.22.513328 +V216Q,NP_000537:p.Val216Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.82484,3.067044496536255,3.17687,3.1007788733670854,4.500855,4.462809436683543,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.61,E,-0.4801,0.0589,-22.2419,-7.86367800860004,0.8700875517357861,Pathogenic,0.9967,pathogenic,-4.502,available,https://doi.org/10.1101/2022.10.22.513328 +V216R,NP_000537:p.Val216Arg,"hg19,17:g.7578202_7578203delinsCT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.84065,3.176487684249878,5.99898,4.307556589887908,7.419815,6.574103294943955,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.61,E,-0.5294,0.0589,-22.2419,-7.86367800860004,0.8707826014486361,Pathogenic,0.9956,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328 +V216S,NP_000537:p.Val216Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.71754,2.8594253063201904,3.27857,3.642787216112081,3.498055,3.6801636080560405,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.61,E,-0.3814,0.0589,-8.9541,-6.40680338440801,0.8668588301280018,Pathogenic,0.96,pathogenic,-4.256,available,https://doi.org/10.1101/2022.10.22.513328 +V216T,NP_000537:p.Val216Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.46763,2.2896881103515625,1.57925,2.137456656670781,2.02344,2.302543328335391,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.61,E,-0.3646,0.0589,-22.2419,-4.64532572970529,0.7461695455299772,Pathogenic,0.882,pathogenic,-3.96,available,https://doi.org/10.1101/2022.10.22.513328 +V216W,NP_000537:p.Val216Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,18.03766,2.796982288360596,4.93435,3.6319152070344938,11.486004999999999,10.834787603517245,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.61,E,-0.4633,0.0589,-22.2419,-7.86367800860004,0.8398159294110228,Pathogenic,0.9998,pathogenic,-4.602,available,https://doi.org/10.1101/2022.10.22.513328 +V216Y,NP_000537:p.Val216Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,15.49082,2.633118391036988,5.15918,3.582244774911685,10.325,9.536532387455843,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.421,,,,,,,,,0.5,,True,0.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.61,E,-0.4662,0.0589,-22.2419,-7.86367800860004,0.8661691621949326,Pathogenic,0.9993,pathogenic,-4.473,available,https://doi.org/10.1101/2022.10.22.513328 +V217A,NP_000537:p.Val217Ala,"hg19,17:g.7578199A>G, hg38,17:g.7674881A>G",,,0.647,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.51092,1.823971509933472,2.35034,1.0315350190438235,2.43063,1.7712275095219119,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.79,E,-0.0771,2.1286,-6.9571,-2.14745108374035,5.431745333075285e-06,Benign,0.3266,benign,-3.348,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V217C,NP_000537:p.Val217Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.53742,1.20452618598938,2.13537,1.366202430432919,2.336395,1.9518112152164595,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.79,E,-0.102,2.1286,-6.3721,-2.22935959270386,3.167327535270623e-05,Benign,0.8129,pathogenic,-3.524,available,https://doi.org/10.1101/2022.10.22.513328 +V217D,NP_000537:p.Val217Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.26366,2.998689651489258,3.55612,1.5004154088201778,3.90989,2.882037704410089,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.79,E,-0.2539,2.1286,-8.957,-4.97791765137677,0.0549242798352804,Benign,0.9656,pathogenic,-4.013,available,https://doi.org/10.1101/2022.10.22.513328 +V217E,NP_000537:p.Val217Glu,"hg19,17:g.7578199A>T, hg38,17:g.7674881A>T",,,0.723,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.03404,2.1928985118865967,2.63197,1.1673375035453966,2.833005,2.100688751772698,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.79,E,-0.279,2.1286,-22.2448,-4.97791765137677,0.4003982983912539,Uncertain,0.8706,pathogenic,-4.08,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V217F,NP_000537:p.Val217Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.90535,1.1221922636032104,2.34558,0.3796557929847832,5.625465,4.642502896492392,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.79,E,-0.1543,2.1286,-6.9571,-2.17564102055245,0.0372337065038907,Benign,0.597,pathogenic,-3.591,available,https://doi.org/10.1101/2022.10.22.513328 +V217G,NP_000537:p.Val217Gly,"hg19,17:g.7578198_7578199delinsAC, hg19,17:g.7578199A>C, hg19,17:g.7674881A>C, hg38,17:g.7674881A>C",,,0.731,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.88703,3.1439130306243896,4.68741,2.757147076667019,4.28722,3.3220885383335097,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.79,E,-0.208,2.1286,-7.957,-3.08625379543033,0.0023281309902917,Benign,0.7,pathogenic,-3.831,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V217H,NP_000537:p.Val217His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.84506,2.1045753955841064,3.03503,1.029105590132814,5.440045,4.437082795066408,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.79,E,-0.3247,2.1286,-22.2448,-3.9406222399082,0.2321525260214935,Benign,0.9525,pathogenic,-4.13,available,https://doi.org/10.1101/2022.10.22.513328 +V217I,NP_000537:p.Val217Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.06496,0.1598515510559082,0.13503,-0.162364454641391,1.099995,0.9512977726793046,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.79,E,-0.0097,2.1286,-6.3721,-1.43408541530922,3.291268268078736e-06,Benign,0.1097,benign,-3.194,available,https://doi.org/10.1101/2022.10.22.513328 +V217K,NP_000537:p.Val217Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.23166,2.102222204208374,2.84116,1.8644134549019915,3.03641,2.548036727450996,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.79,E,-0.318,2.1286,-22.2448,-3.71481439691539,0.0131949051782018,Benign,0.9374,pathogenic,-3.907,available,https://doi.org/10.1101/2022.10.22.513328 +V217L,NP_000537:p.Val217Leu,"hg19,17:g.7578200C>A, hg19,17:g.7578200C>G, hg38,17:g.7674882C>A",,,0.544,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1386154,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.72535,1.3044708967208862,0.60408,-0.0639353504825057,0.664715,0.3307073247587472,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.79,E,-0.0482,2.1286,-1.1627,-0.539631388372405,7.646786506834938e-07,Benign,0.3919,ambiguous,-3.071,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V217M,NP_000537:p.Val217Met,"hg19,17:g.7578200C>T, hg38,17:g.7674882C>T",,3.9769970491e-06,0.451,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",183071,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.87297,1.4607312679290771,1.42653,0.3813696902687752,1.14975,0.6271698451343877,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.79,E,-0.0682,2.1286,-3.3132,-1.40428730991163,0.0003601299173597,Benign,0.3012,benign,-3.274,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V217N,NP_000537:p.Val217Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.60491,2.7190279960632324,2.17653,1.080687285803983,2.89072,2.3427986429019914,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.79,E,-0.3096,2.1286,-22.2448,-4.88421572979935,0.0777185368210788,Benign,0.9073,pathogenic,-3.906,available,https://doi.org/10.1101/2022.10.22.513328 +V217P,NP_000537:p.Val217Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.16333,3.6043310165405273,4.23265,3.28321535507749,5.19799,4.723272677538745,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.79,E,-0.3595,2.1286,-22.2448,-5.33840963704239,0.3005360150511274,Benign,0.9959,pathogenic,-4.132,available,https://doi.org/10.1101/2022.10.22.513328 +V217Q,NP_000537:p.Val217Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.45669,2.03882360458374,2.12993,1.031363771032553,1.79331,1.2440268855162766,Uncertain,Neutral,Destabilizing,Neutral,Neutral,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.79,E,-0.2897,2.1286,-22.2448,-4.97791765137677,0.1720459207965658,Benign,0.8476,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328 +V217R,NP_000537:p.Val217Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.43805,1.8662749528884888,3.14014,1.2098622716077103,3.289095,2.323956135803855,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.79,E,-0.2712,2.1286,-8.957,-3.10712675617726,0.0030653230066194,Benign,0.8821,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328 +V217S,NP_000537:p.Val217Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.69634,2.089228630065918,2.76939,1.7730000513346766,3.2328650000000003,2.7346700256673384,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.79,E,-0.1829,2.1286,-7.3721,-1.45163155614739,4.887914890137701e-05,Benign,0.5319,ambiguous,-3.431,available,https://doi.org/10.1101/2022.10.22.513328 +V217T,NP_000537:p.Val217Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.27343,1.3208351135253906,1.96769,0.9290889941245072,2.12056,1.6012594970622536,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.79,E,-0.0771,2.1286,-3.2292,-2.04752250805652,4.929221949433084e-07,Benign,0.2832,benign,-3.189,available,https://doi.org/10.1101/2022.10.22.513328 +V217W,NP_000537:p.Val217Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.88471,1.0173572301864624,0.73129,0.5974084507216099,5.808,5.741059225360805,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.79,E,-0.205,2.1286,-8.957,-2.55738323022044,0.0368353917147424,Benign,0.9613,pathogenic,-4.116,available,https://doi.org/10.1101/2022.10.22.513328 +V217Y,NP_000537:p.Val217Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.23969,0.995081663131714,2.43197,0.8626100580618203,6.33583,5.55115002903091,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,True,0.456,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.79,E,-0.2079,2.1286,-8.957,-2.29664129861387,0.0150135026458018,Benign,0.9199,pathogenic,-3.854,available,https://doi.org/10.1101/2022.10.22.513328 +V218A,NP_000537:p.Val218Ala,"hg38,17:g.7674878A>G",,,0.974,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.93758,2.017852306365967,2.6415,2.2030059068827743,2.78954,2.5702929534413874,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.71,E,-0.3301,0.227,-22.2448,-4.07629893885742,0.2312405653619732,Benign,0.8565,pathogenic,-3.778,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V218C,NP_000537:p.Val218Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.31081,1.2425261735916138,2.59932,2.016490687225536,2.4550650000000003,2.163650343612768,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.71,E,-0.2902,0.227,-8.957,-5.55160402836846,0.6470775282990314,Uncertain,0.94,pathogenic,-4.092,available,https://doi.org/10.1101/2022.10.22.513328 +V218D,NP_000537:p.Val218Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.82582,3.400232553482056,4.1483,3.319473269518807,4.48706,4.072646634759404,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.71,E,-0.4967,0.227,-22.2448,-6.84820493328757,0.8208157450786532,Pathogenic,0.9978,pathogenic,-4.612,available,https://doi.org/10.1101/2022.10.22.513328 +V218E,NP_000537:p.Val218Glu,"hg19,17:g.7578196A>T, hg19,17:g.7674878A>T, hg38,17:g.7674878A>T",,,0.977,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1754112,Likely pathogenic,2,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.96931,2.965923309326172,3.68299,2.98382681927843,3.32615,2.9765684096392153,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.71,E,-0.454,0.227,-22.2448,-6.84820493328757,0.8427049062844838,Pathogenic,0.99,pathogenic,-4.549,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V218F,NP_000537:p.Val218Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.43208,2.0514612197875977,1.5602,1.2160821133593052,2.49614,2.3240810566796526,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.71,E,-0.4073,0.227,-22.2448,-5.14926000963313,0.2814432000834319,Benign,0.8712,pathogenic,-3.984,available,https://doi.org/10.1101/2022.10.22.513328 +V218G,NP_000537:p.Val218Gly,"hg19,17:g.7578196A>C, hg19,17:g.7674878A>C, hg38,17:g.7674878A>C",,,0.972,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528249,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.2396,3.3154752254486084,4.92415,4.20242251704917,4.581875,4.221011258524586,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.71,E,-0.4559,0.227,-22.2448,-6.84820493328757,0.4708204641576821,Uncertain,0.9144,pathogenic,-4.352,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V218H,NP_000537:p.Val218His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.92954,3.1393628120422363,3.42211,2.1448251014025743,4.675825,4.037182550701287,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.71,E,-0.4997,0.227,-22.2448,-5.99807811825051,0.8154172166641043,Pathogenic,0.9962,pathogenic,-4.57,available,https://doi.org/10.1101/2022.10.22.513328 +V218I,NP_000537:p.Val218Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01033,0.2557859420776367,0.92789,0.0194262842652553,0.46910999999999997,0.014878142132627649,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.71,E,-0.1927,0.227,-7.957,-1.01884231858046,0.0012174353382078,Benign,0.1778,benign,-3.271,available,https://doi.org/10.1101/2022.10.22.513328 +V218K,NP_000537:p.Val218Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.10009,3.123875379562378,4.12687,3.57997202333852,3.61348,3.34003101166926,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.71,E,-0.493,0.227,-22.2448,-6.84820493328757,0.8122807930460171,Pathogenic,0.9941,pathogenic,-4.634,available,https://doi.org/10.1101/2022.10.22.513328 +V218L,NP_000537:p.Val218Leu,"hg19,17:g.7578197C>A, hg19,17:g.7674879C>A, hg38,17:g.7674879C>A",,,0.864,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.09031,1.0386511087417605,0.78571,0.2015209383844701,0.3477,0.05560546919223505,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.71,E,-0.2468,0.227,-5.7872,-2.07009444312409,0.0001224813597769,Benign,0.7135,pathogenic,-3.347,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V218M,NP_000537:p.Val218Met,"hg19,17:g.7578197C>T, hg19,17:g.7578197_7578198delinsTT, hg19,17:g.7674879_7674880delinsTT, hg38,17:g.7674879C>T, hg38,17:g.7674879_7674880delinsTT",,,0.873,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",237952,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28419,1.3676621913909912,1.5381,1.0985333189345736,0.911145,0.6913616594672868,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.71,E,-0.3398,0.227,-22.2448,-3.15165734968342,0.0683214397083793,Benign,0.7748,pathogenic,-3.768,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V218N,NP_000537:p.Val218Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.24338,3.382112979888916,2.80714,2.233406992647053,3.0252600000000003,2.7383934963235266,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.71,E,-0.4846,0.227,-22.2448,-6.84820493328757,0.8213553149591172,Pathogenic,0.9918,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +V218P,NP_000537:p.Val218Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.91765,3.753884077072144,2.98299,4.782351603438306,3.45032,4.350000801719153,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.71,E,-0.5344,0.227,-22.2448,-6.84820493328757,0.8275669389609562,Pathogenic,0.9965,pathogenic,-4.465,available,https://doi.org/10.1101/2022.10.22.513328 +V218Q,NP_000537:p.Val218Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.68157,2.693437337875366,2.86565,2.253908451206174,2.27361,1.9677392256030868,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.71,E,-0.4646,0.227,-22.2448,-6.84820493328757,0.6884592284117206,Pathogenic,0.9843,pathogenic,-4.516,available,https://doi.org/10.1101/2022.10.22.513328 +V218R,NP_000537:p.Val218Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.8012,3.116536855697632,3.83878,2.6409473850560787,2.3199899999999998,1.7210736925280394,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.71,E,-0.514,0.227,-22.2448,-6.84820493328757,0.8462167925899768,Pathogenic,0.9872,pathogenic,-4.577,available,https://doi.org/10.1101/2022.10.22.513328 +V218S,NP_000537:p.Val218Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.83313,2.663428783416748,3.47007,2.9374291422425656,3.1516,2.885279571121283,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.71,E,-0.4338,0.227,-22.2448,-4.82234701020296,0.2872875302666632,Benign,0.9448,pathogenic,-4.08,available,https://doi.org/10.1101/2022.10.22.513328 +V218T,NP_000537:p.Val218Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.32377,1.6804335117340088,1.83197,1.537447073035216,1.5778699999999999,1.430608536517608,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.71,E,-0.3491,0.227,-22.2448,-4.02487502035216,0.0193278380673465,Benign,0.8347,pathogenic,-3.717,available,https://doi.org/10.1101/2022.10.22.513328 +V218W,NP_000537:p.Val218Trp,"hg19,17:g.7578196_7578197delinsCA",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.21458,2.5428006649017334,2.17075,1.840034966979569,2.692665,2.5273074834897846,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.71,E,-0.4478,0.227,-22.2448,-5.99807811825051,0.786403056085973,Pathogenic,0.9974,pathogenic,-4.656,available,https://doi.org/10.1101/2022.10.22.513328 +V218Y,NP_000537:p.Val218Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.31824,2.654418468475342,1.77925,2.0352680339205147,3.0487450000000003,3.1767540169602575,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.391,,,,,,,,,2.7,,False,2.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.71,E,-0.3778,0.227,-7.957,-3.68767768601299,0.0502276369279152,Benign,0.9912,pathogenic,-4.084,available,https://doi.org/10.1101/2022.10.22.513328 +P219A,NP_000537:p.Pro219Ala,"hg19,17:g.7578194G>C, hg38,17:g.7674876G>C",,,0.937,"cBioPortal,ClinVar,saturation_mutlist",2850523,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.09723,1.481858253479004,1.35374,0.6222682635081408,1.725485,1.3597491317540704,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.66,E,-0.3174,0.1119,-22.2448,-5.98951135681437,0.0433620437223079,Benign,0.3597,ambiguous,-3.882,available,https://doi.org/10.1101/2022.10.22.513328 +P219C,NP_000537:p.Pro219Cys,"hg38,17:g.7674875_7674876delinsCA",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.91171,0.7553586959838867,1.67109,1.308490737969576,1.7913999999999999,1.6101003689847881,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.66,E,-0.3501,0.1119,-22.2448,-6.95438318069062,0.8131674984941484,Pathogenic,0.8789,pathogenic,-4.453,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P219D,NP_000537:p.Pro219Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.83884,1.6280769109725952,1.09898,0.6924598403255366,1.96891,1.7656499201627682,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.66,E,-0.3082,0.1119,-8.957,-4.07040711956028,0.1107043264782746,Benign,0.8527,pathogenic,-4.096,available,https://doi.org/10.1101/2022.10.22.513328 +P219E,NP_000537:p.Pro219Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.05469,1.561565399169922,1.12245,0.5439020872029012,1.5885699999999998,1.2992960436014505,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.66,E,-0.3598,0.1119,-22.2448,-5.74473666335954,0.2219269852982077,Benign,0.7876,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +P219F,NP_000537:p.Pro219Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.36321,1.0100901126861572,0.58912,-0.1465275879935129,0.976165,0.6083412060032436,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.66,E,-0.3785,0.1119,-22.2448,-7.82669451732048,0.4780335939451759,Uncertain,0.9443,pathogenic,-4.548,available,https://doi.org/10.1101/2022.10.22.513328 +P219G,NP_000537:p.Pro219Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.25286,1.6355361938476562,2.55476,1.7264721759628447,2.40381,1.9896660879814223,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.66,E,-0.3318,0.1119,-22.2448,-7.82669451732048,0.7649985781762616,Pathogenic,0.7935,pathogenic,-4.307,available,https://doi.org/10.1101/2022.10.22.513328 +P219H,NP_000537:p.Pro219His,"hg19,17:g.7578193G>T, hg38,17:g.7674875G>T",,,0.957,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.22423,1.3065710067749023,1.41939,0.1124649968660301,1.82181,1.168347498433015,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.66,E,-0.3561,0.1119,-22.2448,-7.82669451732048,0.8292994102900393,Pathogenic,0.7211,pathogenic,-4.339,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P219I,NP_000537:p.Pro219Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.33775,1.1791317462921145,0.76259,-0.163065215348801,1.05017,0.5873423923255995,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.66,E,-0.3616,0.1119,-22.2448,-6.41984487557022,0.714270966358717,Pathogenic,0.9078,pathogenic,-4.488,available,https://doi.org/10.1101/2022.10.22.513328 +P219K,NP_000537:p.Pro219Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.9721,1.2735679149627686,1.8602,0.6420005267319092,1.91615,1.3070502633659546,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.66,E,-0.3515,0.1119,-22.2448,-7.82669451732048,0.8322385477189075,Pathogenic,0.8947,pathogenic,-4.404,available,https://doi.org/10.1101/2022.10.22.513328 +P219L,NP_000537:p.Pro219Leu,"hg19,17:g.7578193G>A, hg38,17:g.7674874_7674875delinsAA, hg38,17:g.7674875G>A",,3.9777563863e-06,0.947,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",826488,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.5995,0.9632821679115297,1.00782,-0.446662029637655,1.3036599999999998,0.5764189851811725,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.66,E,-0.2903,0.1119,-7.3721,-4.32516605469899,0.0014420978298074,Benign,0.4909,ambiguous,-3.799,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P219M,NP_000537:p.Pro219Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.29682,1.190199851989746,1.18673,0.013456763036353,1.241775,0.6551383815181765,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.66,E,-0.3171,0.1119,-22.2448,-5.08192340945849,0.4135269531978684,Uncertain,0.8683,pathogenic,-4.213,available,https://doi.org/10.1101/2022.10.22.513328 +P219N,NP_000537:p.Pro219Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.38474,1.4579025506973269,1.82823,0.6934479561013881,2.106485,1.539093978050694,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.66,E,-0.3441,0.1119,-22.2448,-6.71122325445307,0.8285104573792726,Pathogenic,0.8278,pathogenic,-4.304,available,https://doi.org/10.1101/2022.10.22.513328 +P219Q,NP_000537:p.Pro219Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.97655,1.5759503841400146,0.71599,0.572515887800353,1.34627,1.2745329439001765,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.66,E,-0.3458,0.1119,-22.2448,-6.02574466933147,0.1233243002268471,Benign,0.6649,pathogenic,-3.94,available,https://doi.org/10.1101/2022.10.22.513328 +P219R,NP_000537:p.Pro219Arg,"hg19,17:g.7578193G>C, hg38,17:g.7674875G>C",,,0.966,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",953426,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.07698,1.24396014213562,1.38469,0.3715953789973319,1.730835,1.2242876894986658,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.66,E,-0.3872,0.1119,-22.2448,-7.82669451732048,0.723905110394788,Pathogenic,0.6961,pathogenic,-4.176,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P219S,NP_000537:p.Pro219Ser,"hg19,17:g.7578194G>A, hg38,17:g.7674876G>A",,3.9775665248e-06,0.960,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",245673,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.22735,1.5129306316375732,1.82925,0.8506144582287006,2.0282999999999998,1.5389822291143502,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.66,E,-0.2442,0.1119,-7.957,-4.97570162335351,0.0104918826415043,Benign,0.5148,ambiguous,-3.704,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P219T,NP_000537:p.Pro219Thr,"hg19,17:g.7578194G>T, hg38,17:g.7674876G>T",,,0.962,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2758381,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.05162,1.5468592643737793,1.41429,0.5854695090193232,1.732955,1.3185447545096616,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.66,E,-0.3293,0.1119,-22.2448,-6.95438318069062,0.6524069465970148,Uncertain,0.5899,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P219V,NP_000537:p.Pro219Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.06819,1.3895032405853271,0.6119,-0.0745395406810733,1.340045,0.9968252296594633,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.66,E,-0.317,0.1119,-22.2448,-6.41984487557022,0.8301465765786028,Pathogenic,0.7966,pathogenic,-4.495,available,https://doi.org/10.1101/2022.10.22.513328 +P219W,NP_000537:p.Pro219Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.90487,0.8975350856781006,-0.56769,-0.6515416101242238,0.66859,0.6266641949378882,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.66,E,-0.391,0.1119,-22.2448,-7.82669451732048,0.7551148421204195,Pathogenic,0.9584,pathogenic,-4.734,available,https://doi.org/10.1101/2022.10.22.513328 +P219Y,NP_000537:p.Pro219Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.71613,0.8472737073898315,0.56429,-0.0237355737406302,0.64021,0.34619721312968493,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.241,,,Uncertain,,Uncertain,,,Uncertain,29.6,,False,29.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.66,E,-0.3795,0.1119,-22.2448,-7.82669451732048,0.8544565583950675,Pathogenic,0.9331,pathogenic,-4.619,available,https://doi.org/10.1101/2022.10.22.513328 +Y220A,NP_000537:p.Tyr220Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.87618,2.7090325355529785,3.4983,3.516699981130371,3.68724,3.6964399905651857,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,neutral,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.4447,0.0798,-22.2419,-6.98521212435209,0.8376702447375943,Pathogenic,0.9905,pathogenic,-4.35,available,https://doi.org/10.1101/2022.10.22.513328 +Y220C,NP_000537:p.Tyr220Cys,"hg19,17:g.7578190T>C, hg19,17:g.7674872T>C, hg38,17:g.7674872T>C",,7.9551963342e-06,0.936,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127819,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,3.6908,2.00754714012146,3.19762,4.007217441423339,3.44421,3.8490087207116694,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,neutral,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.4154,0.0798,-22.2419,-6.98521212435209,0.7731185357003707,Pathogenic,0.8515,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y220D,NP_000537:p.Tyr220Asp,"hg19,17:g.7578191A>C, hg19,17:g.7674873A>C, hg38,17:g.7674873A>C",,,0.934,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376689,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.16426,2.729670524597168,4.20272,4.448131013246004,4.68349,4.806195506623002,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,neutral,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.4589,0.0798,-22.2419,-6.87859714830146,0.8658325249148415,Pathogenic,0.9974,pathogenic,-4.65,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y220E,NP_000537:p.Tyr220Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.04928,2.882169246673584,4.26769,4.133860909235725,4.158485000000001,4.091570454617862,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,neutral,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.4876,0.0798,-22.2419,-6.87859714830146,0.8443098962769138,Pathogenic,0.9987,pathogenic,-4.64,available,https://doi.org/10.1101/2022.10.22.513328 +Y220F,NP_000537:p.Tyr220Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.90017,0.3219585418701172,-0.13571,-0.1779647739511652,-0.5179400000000001,-0.5390673869755827,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,damaging,uncertain,-,uncertain,neutral,False,neutral,neutral,97.45,-,-0.2093,0.0798,-7.9541,-2.25535117224147,0.0061200888970215,Benign,0.147,benign,-3.41,available,https://doi.org/10.1101/2022.10.22.513328 +Y220G,NP_000537:p.Tyr220Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.32142,2.781795024871826,5.4398,5.318281921065928,5.38061,5.319850960532964,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,neutral,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.5153,0.0798,-22.2419,-7.64923818364801,0.8093884567161209,Pathogenic,0.9877,pathogenic,-4.524,available,https://doi.org/10.1101/2022.10.22.513328 +Y220H,NP_000537:p.Tyr220His,"hg19,17:g.7578191A>G, hg19,17:g.7578191_7578192delinsGA, hg19,17:g.7674873A>G, hg38,17:g.7674873A>G",,3.9777247414e-06,0.909,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376687,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.35482,2.0290679931640625,2.2415,1.591361504888985,2.29816,1.9730907524444925,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,uncertain,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.3524,0.0798,-22.2419,-3.40666941627912,0.2179055810843693,Benign,0.9633,pathogenic,-3.751,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y220I,NP_000537:p.Tyr220Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.67727,2.210174322128296,2.11531,2.331864336261321,2.39629,2.5045671681306603,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,uncertain,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.389,0.0798,-8.9541,-3.25072197311028,0.1548710356409479,Benign,0.961,pathogenic,-4.135,available,https://doi.org/10.1101/2022.10.22.513328 +Y220K,NP_000537:p.Tyr220Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.61033,2.7892394065856934,3.62347,4.306484596421308,3.1169000000000002,3.4584072982106537,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,uncertain,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.5129,0.0798,-22.2419,-7.64923818364801,0.837933632829506,Pathogenic,0.9989,pathogenic,-4.656,available,https://doi.org/10.1101/2022.10.22.513328 +Y220L,NP_000537:p.Tyr220Leu,,,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.8523,1.9911943674087524,2.33435,1.3184262024535056,1.593325,1.0853631012267528,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,damaging,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.4339,0.0798,-22.2419,-3.10007605983779,0.0549362428711858,Benign,0.8841,pathogenic,-3.783,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y220M,NP_000537:p.Tyr220Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.33446,2.008042812347412,1.31701,1.6977633229053828,0.825735,1.0161116614526913,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,damaging,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.3182,0.0798,-8.9541,-3.28843032415183,0.0823672689418071,Benign,0.9687,pathogenic,-4.014,available,https://doi.org/10.1101/2022.10.22.513328 +Y220N,NP_000537:p.Tyr220Asn,"hg19,17:g.7578191A>T, hg19,17:g.7578191_7578192delinsTA, hg19,17:g.7674873A>T, hg38,17:g.7674873A>T",,,0.910,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376688,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,Tier II - Potential,1,P53 DNA-binding domain (PF00870),2.60.40.720,4.24461,2.7174692153930664,3.38469,3.44789284461105,3.81465,3.846251422305525,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,neutral,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.4379,0.0798,-22.2419,-6.87859714830146,0.8631746615947256,Pathogenic,0.9869,pathogenic,-4.452,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y220P,NP_000537:p.Tyr220Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.55223,2.601772785186768,7.31088,7.520270233428679,8.431555,8.536250116714339,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,neutral,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.5689,0.0798,-22.2419,-7.64923818364801,0.8644042463264392,Pathogenic,0.9963,pathogenic,-4.492,available,https://doi.org/10.1101/2022.10.22.513328 +Y220Q,NP_000537:p.Tyr220Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.31816,2.701200246810913,2.61122,3.341615166229384,2.96469,3.329887583114692,Uncertain,Destabilizing,Destabilizing,Uncertain,Destabilizing,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,neutral,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.4624,0.0798,-22.2419,-5.94502452030999,0.6627559958961791,Uncertain,0.9977,pathogenic,-4.166,available,https://doi.org/10.1101/2022.10.22.513328 +Y220R,NP_000537:p.Tyr220Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.13978,2.5355942249298096,3.61293,3.21540009695196,2.876355,2.67759004847598,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,uncertain,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.5083,0.0798,-22.2419,-7.64923818364801,0.8616973762724278,Pathogenic,0.9944,pathogenic,-4.438,available,https://doi.org/10.1101/2022.10.22.513328 +Y220S,NP_000537:p.Tyr220Ser,"hg19,17:g.7578190T>G, hg19,17:g.7674872T>G, hg38,17:g.7674872T>G",,,0.918,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12383,Pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,4.61154,2.750457286834717,4.21565,4.478796791453627,4.413595,4.545168395726813,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,neutral,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.4494,0.0798,-22.2419,-4.64453510359499,0.8278260210664181,Pathogenic,0.9754,pathogenic,-4.262,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y220T,NP_000537:p.Tyr220Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.10683,2.692166566848755,4.03367,3.883533564115997,4.07025,3.9951817820579985,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,neutral,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.4681,0.0798,-22.2419,-6.03610522399727,0.6683704482689345,Uncertain,0.991,pathogenic,-4.244,available,https://doi.org/10.1101/2022.10.22.513328 +Y220V,NP_000537:p.Tyr220Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.49998,2.369096040725708,3.00816,2.584723639207408,3.25407,3.042351819603704,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,neutral,uncertain,DOWN,stabilizing,neutral,False,neutral,neutral,97.45,-,-0.4463,0.0798,-22.2419,-5.03467392689524,0.3728371322905478,Uncertain,0.9067,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +Y220W,NP_000537:p.Tyr220Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.56918,0.2787935733795166,-0.41497,0.2197983651737622,-0.992075,-0.6746908174131189,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.088,,,,,,,,,5.5,P,False,5.5,7.31,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,97.45,-,-0.3623,0.0798,-22.2419,-4.5982958609189,0.8215901885740375,Pathogenic,0.6147,pathogenic,-4.148,available,https://doi.org/10.1101/2022.10.22.513328 +E221A,NP_000537:p.Glu221Ala,"hg19,17:g.7578187T>G, hg38,17:g.7674869T>G",,,0.880,"ClinVar,saturation_mutlist",573679,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.54486,1.0318180322647097,0.89898,0.6296235842092596,0.72192,0.5872417921046298,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.2355,0.1886,-8.9599,-5.59593430062344,0.2631970581826228,Benign,0.6479,pathogenic,-3.78,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E221C,NP_000537:p.Glu221Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14699,0.5781522393226624,1.17857,1.2734993709360125,0.6627799999999999,0.7102446854680062,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.3727,0.1886,-22.2477,-5.73709184939154,0.212968196276467,Benign,0.956,pathogenic,-4.144,available,https://doi.org/10.1101/2022.10.22.513328 +E221D,NP_000537:p.Glu221Asp,"hg38,17:g.7674868C>A, hg38,17:g.7674868C>G",,,0.669,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.41871,0.8753371238708496,0.92517,0.6390692100545389,0.67194,0.5288896050272694,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.2012,0.1886,-8.9599,-0.510158117387993,0.0086585152945743,Benign,0.4842,ambiguous,-3.471,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E221F,NP_000537:p.Glu221Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.84327,1.0106234550476074,-0.38061,0.0211649789904627,-0.6119399999999999,-0.41105251050476865,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.3503,0.1886,-22.2477,-6.52075244133916,0.7987544987824662,Pathogenic,0.9697,pathogenic,-4.494,available,https://doi.org/10.1101/2022.10.22.513328 +E221G,NP_000537:p.Glu221Gly,"hg19,17:g.7674869T>C, hg38,17:g.7674869T>C",,,0.826,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.15092,1.6897697448730469,2.00476,2.0116937204602867,1.5778400000000001,1.5813068602301432,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.3291,0.1886,-22.2477,-5.94248562830314,0.2103720282459079,Benign,0.7281,pathogenic,-3.814,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E221H,NP_000537:p.Glu221His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.13825,0.9905250072479248,0.28912,0.2491866383793656,0.07543499999999999,0.0554683191896828,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.3416,0.1886,-22.2477,-5.82212209907457,0.3459677636633074,Uncertain,0.8882,pathogenic,-3.974,available,https://doi.org/10.1101/2022.10.22.513328 +E221I,NP_000537:p.Glu221Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.87561,0.6675371527671814,-0.01463,-0.404176161242909,-0.44512,-0.6398930806214544,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.3557,0.1886,-22.2477,-6.59482766227259,0.6433239782697077,Uncertain,0.8022,pathogenic,-4.322,available,https://doi.org/10.1101/2022.10.22.513328 +E221K,NP_000537:p.Glu221Lys,"hg19,17:g.7578188C>T, hg38,17:g.7674870C>T",,3.9780095631e-06,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",184647,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.50011,1.1344295740127563,-0.36054,0.5713501163494378,-0.43032500000000007,0.03562005817471886,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.2575,0.1886,-8.9599,-2.48019949466779,0.0509590519823074,Benign,0.7104,pathogenic,-3.98,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E221L,NP_000537:p.Glu221Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.47983,0.7621161341667175,-0.09694,-0.3923349312249435,-0.288385,-0.43608246561247177,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.3578,0.1886,-22.2477,-6.11604798614406,0.4309748658286487,Uncertain,0.8355,pathogenic,-4.023,available,https://doi.org/10.1101/2022.10.22.513328 +E221M,NP_000537:p.Glu221Met,"hg19,17:g.7578187_7578188delinsAT, hg38,17:g.7674869_7674870delinsAT",,,,"ClinVar,saturation_mutlist",2824912,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.51623,0.8590278029441833,0.56429,0.0639585460933234,-0.47597,-0.7261357269533383,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.3066,0.1886,-22.2477,-6.92433865170428,0.8566867833812014,Pathogenic,0.8436,pathogenic,-4.392,available,https://doi.org/10.1101/2022.10.22.513328 +E221N,NP_000537:p.Glu221Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.10158,1.1523330211639404,1.0051,0.58256346168158,0.55334,0.34207173084079,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.3295,0.1886,-22.2477,-3.6224616095687,0.0939398907455993,Benign,0.7825,pathogenic,-3.88,available,https://doi.org/10.1101/2022.10.22.513328 +E221P,NP_000537:p.Glu221Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.47532,2.3330466747283936,0.67517,2.5532619501345275,0.575245,1.5142909750672637,Neutral,Uncertain,Destabilizing,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.4603,0.1886,-22.2477,-7.5825594103199,0.8182847858013036,Pathogenic,0.9769,pathogenic,-4.12,available,https://doi.org/10.1101/2022.10.22.513328 +E221Q,NP_000537:p.Glu221Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.37912,0.5296599864959717,0.42279,0.6397428742313468,0.021834999999999993,0.1303114371156734,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.1978,0.1886,-6.96,-2.45338590443034,0.0008066636635304,Benign,0.4052,ambiguous,-3.496,available,https://doi.org/10.1101/2022.10.22.513328 +E221R,NP_000537:p.Glu221Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.51102,1.33034348487854,-0.31565,0.2581988558585846,-0.413335,-0.12641057207070772,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.3858,0.1886,-22.2477,-5.32530863535971,0.4005721487426265,Uncertain,0.7804,pathogenic,-3.966,available,https://doi.org/10.1101/2022.10.22.513328 +E221S,NP_000537:p.Glu221Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.19794,0.8075305819511414,0.4119,0.806359873956989,0.30491999999999997,0.5021499369784945,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.2439,0.1886,-7.9599,-3.54897606682575,0.0283479585202205,Benign,0.6446,pathogenic,-3.584,available,https://doi.org/10.1101/2022.10.22.513328 +E221T,NP_000537:p.Glu221Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.03085,0.36762535572052,0.27177,0.4320420652291457,0.12046000000000001,0.20059603261457284,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.2649,0.1886,-8.9599,-3.50966861286784,0.0460218119494903,Benign,0.6731,pathogenic,-3.752,available,https://doi.org/10.1101/2022.10.22.513328 +E221V,NP_000537:p.Glu221Val,"hg38,17:g.7674869T>A",,,0.901,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15039,0.5091402530670166,-0.19796,-0.2032923528888597,-0.174175,-0.17684117644442984,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.01,-,-0.3166,0.1886,-22.2477,-6.92433865170428,0.773417038277459,Pathogenic,0.6334,pathogenic,-4.098,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E221W,NP_000537:p.Glu221Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.42455,1.1046020984649658,0.84252,-0.5189961588847131,0.20898500000000003,-0.4717730794423565,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.3604,0.1886,-22.2477,-6.52075244133916,0.7462972882761,Pathogenic,0.9915,pathogenic,-4.509,available,https://doi.org/10.1101/2022.10.22.513328 +E221Y,NP_000537:p.Glu221Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.61911,1.040518283843994,-0.97075,0.1120337171666052,-0.79493,-0.2535381414166974,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,54.0,,False,54.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.01,-,-0.3512,0.1886,-22.2477,-6.52075244133916,0.7773936456538608,Pathogenic,0.9574,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +P222A,NP_000537:p.Pro222Ala,"hg38,17:g.7674867G>C",,,0.395,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.52795,0.5846042037010193,1.29184,0.0503818584189824,1.4098950000000001,0.7891659292094911,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.1255,1.2061,-4.375,-1.99439351178775,2.391935255166569e-07,Benign,0.0808,benign,-3.112,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P222C,NP_000537:p.Pro222Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.60888,0.4495275020599365,2.13605,0.492049258113959,1.872465,1.0504646290569795,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.46,-,-0.1765,1.2061,-7.9599,-2.02411212241074,0.001071223980196,Benign,0.3919,ambiguous,-3.833,available,https://doi.org/10.1101/2022.10.22.513328 +P222D,NP_000537:p.Pro222Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.05999,0.7695388793945312,0.72177,0.0205964662359386,0.89088,0.5402932331179693,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.46,-,-0.2753,1.2061,-22.2477,-3.083358929793,0.0017495402429779,Benign,0.4956,ambiguous,-3.884,available,https://doi.org/10.1101/2022.10.22.513328 +P222E,NP_000537:p.Pro222Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.9099,0.4197425246238708,0.38741,-0.2783394547221512,0.648655,0.3157802726389244,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.1913,1.2061,-8.9599,-3.6155304032592,8.998455961880043e-07,Benign,0.2873,benign,-3.542,available,https://doi.org/10.1101/2022.10.22.513328 +P222F,NP_000537:p.Pro222Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.58548,0.7976003885269165,1.71293,-0.343331221164212,1.649205,0.6210743894178941,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.2779,1.2061,-22.2477,-4.50963856483679,0.0252823042548482,Benign,0.4084,ambiguous,-3.906,available,https://doi.org/10.1101/2022.10.22.513328 +P222G,NP_000537:p.Pro222Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.01984,1.277806520462036,1.28673,0.7718205993062754,1.653285,1.3958302996531375,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.1552,1.2061,-7.375,-2.75766113939397,0.0001067030283119,Benign,0.2928,benign,-3.496,available,https://doi.org/10.1101/2022.10.22.513328 +P222H,NP_000537:p.Pro222His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.66328,0.7660754919052124,1.23639,-0.3528256139479996,1.4498350000000002,0.6552271930260003,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.1758,1.2061,-6.6381,-2.8801891834461,6.587257282736675e-05,Benign,0.2007,benign,-3.374,available,https://doi.org/10.1101/2022.10.22.513328 +P222I,NP_000537:p.Pro222Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.326,0.6450079679489136,1.79082,-0.2888361649312332,1.55841,0.5185819175343834,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.1931,1.2061,-8.9599,-3.67786415987998,0.0018139773314071,Benign,0.2769,benign,-3.761,available,https://doi.org/10.1101/2022.10.22.513328 +P222K,NP_000537:p.Pro222Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.99816,0.9429643154144288,1.21054,-0.140460829263706,1.10435,0.428849585368147,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.1712,1.2061,-6.6381,-2.793301112349,2.9979821356448064e-06,Benign,0.2985,benign,-3.476,available,https://doi.org/10.1101/2022.10.22.513328 +P222L,NP_000537:p.Pro222Leu,"hg19,17:g.7578184G>A, hg38,17:g.7674866G>A, hg38,17:g.7674866_7674867delinsAA",6.37226789014e-05,1.59154570919e-05,0.585,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",161397,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.91611,0.3574797511100769,0.51939,-0.6145296577966591,0.71775,0.15079017110167042,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.1845,1.2061,-6.375,-1.39143923387326,6.50720818059762e-08,Benign,0.0964,benign,-3.316,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P222M,NP_000537:p.Pro222Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.84763,0.5481069087982178,0.66769,-0.3187828459150893,0.75766,0.26442357704245534,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.1384,1.2061,-6.96,-2.59893132126097,0.0002073534908524,Benign,0.2249,benign,-3.607,available,https://doi.org/10.1101/2022.10.22.513328 +P222N,NP_000537:p.Pro222Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.35806,0.9301705360412598,1.10238,-0.021869377949743,1.23022,0.6680953110251285,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.46,-,-0.2435,1.2061,-22.2477,-3.08376196317857,0.0017564444981529,Benign,0.3124,benign,-3.637,available,https://doi.org/10.1101/2022.10.22.513328 +P222Q,NP_000537:p.Pro222Gln,"hg19,17:g.7578184G>T, hg38,17:g.7674866G>T",,,0.626,"COSMIC,ClinVar,saturation_mutlist",1461784,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.27729,0.6921044588088989,0.6983,-0.0073831292122,0.987795,0.6349534353939,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.1723,1.2061,-7.9599,-2.72420196645075,0.0003169390472358,Benign,0.1551,benign,-3.329,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P222R,NP_000537:p.Pro222Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.06174,1.0100313425064087,1.31531,-0.1835892716338449,1.1885249999999998,0.4390753641830775,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.2056,1.2061,-6.375,-2.80233565190028,7.886288967924056e-06,Benign,0.1863,benign,-3.448,available,https://doi.org/10.1101/2022.10.22.513328 +P222S,NP_000537:p.Pro222Ser,"hg19,17:g.7578185G>A, hg38,17:g.7674867G>A",,,0.344,"COSMIC,ClinVar,saturation_mutlist",406592,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.87344,0.760010302066803,0.93401,0.0873355691586452,1.4037250000000001,0.9803877845793226,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.1298,1.2061,-5.2596,-0.961746201173931,7.118360159508328e-09,Benign,0.1373,benign,-3.13,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P222T,NP_000537:p.Pro222Thr,"hg38,17:g.7674867G>T",,,0.533,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.6781,0.9820221662521362,0.76497,-0.047705522690214,1.221535,0.8151972386548929,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.46,-,-0.1438,1.2061,-5.6381,-1.0716492687091,4.918684802531932e-07,Benign,0.1178,benign,-3.262,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P222V,NP_000537:p.Pro222Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.71673,0.7855149507522583,1.46769,-0.2383470401925042,1.5922100000000001,0.739191479903748,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.1485,1.2061,-8.9599,-3.51861341178905,0.0083152950804751,Benign,0.1847,benign,-3.581,available,https://doi.org/10.1101/2022.10.22.513328 +P222W,NP_000537:p.Pro222Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.77811,0.7170572876930237,0.85612,-0.6949391613500983,1.317115,0.541585419324951,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.2904,1.2061,-22.2477,-4.70625338737446,0.317707952343677,Benign,0.5836,pathogenic,-4.176,available,https://doi.org/10.1101/2022.10.22.513328 +P222Y,NP_000537:p.Pro222Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.6714,0.6620863676071167,1.58435,-0.2334903136431559,1.627875,0.7189548431784221,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.06,,,Uncertain,,Uncertain,,,Uncertain,58.2,,True,58.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,95.46,-,-0.211,1.2061,-8.9599,-2.79555956549886,0.0008931454372717,Benign,0.4246,ambiguous,-3.79,available,https://doi.org/10.1101/2022.10.22.513328 +P223A,NP_000537:p.Pro223Ala,"hg38,17:g.7674864G>C",,,0.759,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.58782,0.6542689800262451,1.00272,0.1005909533177856,1.29527,0.8442054766588928,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.62,-,-0.322,0.0627,-22.2477,-6.17373289280236,0.4471511683644641,Uncertain,0.495,ambiguous,-3.732,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P223C,NP_000537:p.Pro223Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.35265,1.197596549987793,1.80918,0.7487293662800726,2.080915,1.5506896831400363,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.62,-,-0.3546,0.0627,-22.2477,-7.03931855218659,0.7271140237400785,Pathogenic,0.9401,pathogenic,-4.107,available,https://doi.org/10.1101/2022.10.22.513328 +P223D,NP_000537:p.Pro223Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.84892,2.457022190093994,2.71327,0.9383611303607758,3.281095,2.393640565180388,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.62,-,-0.3805,0.0627,-22.2477,-7.31200265301887,0.8579089479537727,Pathogenic,0.992,pathogenic,-4.326,available,https://doi.org/10.1101/2022.10.22.513328 +P223E,NP_000537:p.Pro223Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.92856,1.9647834300994875,2.28265,0.6159992204195038,2.6056049999999997,1.772279610209752,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.62,-,-0.3644,0.0627,-22.2477,-7.31200265301887,0.6981858230877793,Pathogenic,0.9687,pathogenic,-4.332,available,https://doi.org/10.1101/2022.10.22.513328 +P223F,NP_000537:p.Pro223Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.99618,2.056367874145508,0.97721,-0.3482790067899372,1.486695,0.8239504966050315,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.62,-,-0.3831,0.0627,-22.2477,-7.1544350587756,0.6803122835284147,Pathogenic,0.9914,pathogenic,-4.14,available,https://doi.org/10.1101/2022.10.22.513328 +P223G,NP_000537:p.Pro223Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.03946,2.051670789718628,2.56054,1.1831854884067288,2.3,1.6113227442033644,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.62,-,-0.2685,0.0627,-8.9599,-8.13005495551572,0.7348524966380978,Pathogenic,0.9275,pathogenic,-3.929,available,https://doi.org/10.1101/2022.10.22.513328 +P223H,NP_000537:p.Pro223His,"hg19,17:g.7578181G>T, hg38,17:g.7674863G>T",,3.9792442619e-06,0.728,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.87678,2.11912202835083,1.93741,-0.0828521326789849,2.407095,1.3969639336605075,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.62,-,-0.2929,0.0627,-8.9599,-7.32700846970999,0.7223798283739538,Pathogenic,0.9636,pathogenic,-4.038,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P223I,NP_000537:p.Pro223Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.24844,1.9467144012451167,1.64864,0.0444630006618024,3.4485400000000004,2.6464515003309015,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.62,-,-0.3661,0.0627,-22.2477,-7.06470800640211,0.8640871726998501,Pathogenic,0.9709,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +P223K,NP_000537:p.Pro223Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.05541,2.038197755813598,2.10068,0.3397107940695337,2.0780450000000004,1.197560397034767,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.62,-,-0.356,0.0627,-22.2477,-8.13005495551572,0.8571357115504532,Pathogenic,0.977,pathogenic,-4.35,available,https://doi.org/10.1101/2022.10.22.513328 +P223L,NP_000537:p.Pro223Leu,"hg19,17:g.7578181G>A, hg19,17:g.7674863G>A, hg38,17:g.7674863G>A",,,0.634,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",234214,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.96525,2.0162806510925293,1.58469,-0.271416292899389,2.27497,1.3469168535503055,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.62,-,-0.3029,0.0627,-8.9599,-4.36242532907302,0.0178880842883156,Benign,0.838,pathogenic,-3.606,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P223M,NP_000537:p.Pro223Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.51824,1.8383963108062744,1.64014,0.0343207257952504,1.57919,0.7762803628976253,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.62,-,-0.3217,0.0627,-22.2477,-7.06470800640211,0.7950913867305037,Pathogenic,0.9631,pathogenic,-4.381,available,https://doi.org/10.1101/2022.10.22.513328 +P223N,NP_000537:p.Pro223Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.62185,2.1850574016571045,1.77381,0.540813129159727,2.1978299999999997,1.5813315645798633,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.62,-,-0.3487,0.0627,-22.2477,-6.70063033398526,0.6757062470270164,Uncertain,0.9869,pathogenic,-4.051,available,https://doi.org/10.1101/2022.10.22.513328 +P223Q,NP_000537:p.Pro223Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.77569,1.9430131912231443,1.4881,0.4572667340479436,2.131895,1.6164783670239717,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.62,-,-0.3504,0.0627,-22.2477,-7.31200265301887,0.572686355119146,Uncertain,0.9404,pathogenic,-3.96,available,https://doi.org/10.1101/2022.10.22.513328 +P223R,NP_000537:p.Pro223Arg,"hg38,17:g.7674863G>C",,,0.740,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.09,2.237323045730591,0.09218,0.0100057920252943,1.09109,1.050002896012647,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.62,-,-0.3918,0.0627,-22.2477,-8.13005495551572,0.8702323619500463,Pathogenic,0.9182,pathogenic,-4.222,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P223S,NP_000537:p.Pro223Ser,"hg19,17:g.7578182G>A, hg19,17:g.7674864G>A, hg38,17:g.7674864G>A",,,0.765,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.73132,1.3852689266204834,1.57755,0.4741470446530171,2.1544350000000003,1.6027335223265087,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.62,-,-0.3217,0.0627,-22.2477,-5.11965140933339,0.1453155685998165,Benign,0.8509,pathogenic,-3.594,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P223T,NP_000537:p.Pro223Thr,"hg19,17:g.7578182G>T",,,0.786,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.76161,1.8244636058807373,1.58571,0.4395736577239373,2.67366,2.100591828861969,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.62,-,-0.3338,0.0627,-22.2477,-6.53497147428304,0.6637775410532785,Uncertain,0.8645,pathogenic,-3.865,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P223V,NP_000537:p.Pro223Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.7342,1.7471556663513184,1.39218,0.0189063643568826,3.06319,2.3765531821784416,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.62,-,-0.3215,0.0627,-22.2477,-6.85857708020615,0.5864770402733357,Uncertain,0.8961,pathogenic,-3.939,available,https://doi.org/10.1101/2022.10.22.513328 +P223W,NP_000537:p.Pro223Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.09111,2.2033560276031494,1.43878,-0.6831044871712699,1.764945,0.704002756414365,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.62,-,-0.3956,0.0627,-22.2477,-7.58468675385115,0.7738520271856457,Pathogenic,0.9927,pathogenic,-4.586,available,https://doi.org/10.1101/2022.10.22.513328 +P223Y,NP_000537:p.Pro223Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.03366,2.008185386657715,1.5051,-0.2742691283011905,1.76938,0.8796954358494047,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,False,0.036,,,,,,,,,19.7,,True,19.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.62,-,-0.3841,0.0627,-22.2477,-7.58468675385115,0.7045413460683825,Pathogenic,0.9909,pathogenic,-4.304,available,https://doi.org/10.1101/2022.10.22.513328 +E224A,NP_000537:p.Glu224Ala,"hg19,17:g.7578178T>G, hg38,17:g.7674860T>G",,,0.825,"cBioPortal,ClinVar,saturation_mutlist",428892,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.09194,0.128183901309967,-0.01667,0.229093302251167,-0.054305,0.0685766511255835,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2464,0.8075,-22.2477,-5.87663873434466,0.0551339210489787,Benign,0.6237,pathogenic,-3.504,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E224C,NP_000537:p.Glu224Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.27116,0.1092837452888488,0.41599,0.9261250527985898,0.343575,0.5986425263992949,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.3158,0.8075,-22.2477,-6.51966851149614,0.8356706236209989,Pathogenic,0.9819,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328 +E224D,NP_000537:p.Glu224Asp,"hg19,17:g.7578177C>A, hg19,17:g.7578177C>G, hg19,17:g.7674859C>A, hg19,17:g.7674859C>G, hg38,17:g.7674859C>A, hg38,17:g.7674859C>G",,3.9807649438e-06,0.697,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","1493447, 635390","Uncertain significance, Conflicting classifications of pathogenicity","1, 1",Uncertain significance,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.18907,0.3117731213569641,0.10714,0.1793947551478897,0.148105,0.18423237757394484,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.1443,0.8075,-8.9599,-3.60034930259215,0.0830750869694919,Benign,0.8106,pathogenic,-3.568,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E224F,NP_000537:p.Glu224Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01632,0.3346657752990722,0.00952,-0.047924302552143,-0.0034000000000000002,-0.0321221512760715,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2934,0.8075,-22.2477,-6.67883821107086,0.7605456754528067,Pathogenic,0.9931,pathogenic,-4.256,available,https://doi.org/10.1101/2022.10.22.513328 +E224G,NP_000537:p.Glu224Gly,"hg19,17:g.7578178T>C, hg38,17:g.7674860T>C",,,0.890,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",826574,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.13555,0.3260380029678345,0.51735,0.8689337124124347,0.32645,0.5022418562062173,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2721,0.8075,-22.2477,-7.55560463861685,0.7931992917968689,Pathogenic,0.8099,pathogenic,-3.981,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E224H,NP_000537:p.Glu224His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.25109,0.2317343354225158,-0.33129,-0.0582130031943939,-0.0401,0.09643849840280304,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2847,0.8075,-22.2477,-5.85050934729268,0.0829415104625962,Benign,0.9693,pathogenic,-3.684,available,https://doi.org/10.1101/2022.10.22.513328 +E224I,NP_000537:p.Glu224Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.12698,0.2454525828361511,0.48469,-0.0996036655019005,0.305835,0.013688167249049754,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2987,0.8075,-22.2477,-6.84410205171627,0.7788767102719698,Pathogenic,0.9465,pathogenic,-4.034,available,https://doi.org/10.1101/2022.10.22.513328 +E224K,NP_000537:p.Glu224Lys,"hg19,17:g.7578179C>T, hg19,17:g.7674861C>T, hg38,17:g.7674861C>T",,,0.701,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480767,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.04524,0.1037506461143493,-0.51531,0.1244604790542625,-0.23503500000000002,0.08485023952713125,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2684,0.8075,-22.2477,-7.15390804138825,0.4346708784164247,Uncertain,0.9057,pathogenic,-3.782,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E224L,NP_000537:p.Glu224Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.06258,0.3251969218254089,0.01497,-0.1760793311243796,0.038775,-0.0567496655621898,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2331,0.8075,-8.9599,-6.84410205171627,0.8124095656545736,Pathogenic,0.9481,pathogenic,-4.059,available,https://doi.org/10.1101/2022.10.22.513328 +E224M,NP_000537:p.Glu224Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.22128,0.2703496813774109,0.19524,0.1214319087770171,-0.013020000000000004,-0.049924045611491455,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2497,0.8075,-22.2477,-6.84410205171627,0.7459504453004853,Pathogenic,0.9212,pathogenic,-4.004,available,https://doi.org/10.1101/2022.10.22.513328 +E224N,NP_000537:p.Glu224Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28045,0.3226138353347778,0.2966,0.3289999155461137,0.288525,0.30472495777305686,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2726,0.8075,-22.2477,-4.53675363892711,0.741931461197856,Pathogenic,0.9447,pathogenic,-3.88,available,https://doi.org/10.1101/2022.10.22.513328 +E224P,NP_000537:p.Glu224Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.24951,-0.0532348155975341,-1.05884,1.577314689924693,-1.154175,0.16390234496234657,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.4034,0.8075,-22.2477,-5.92380369696755,0.0644721519422535,Benign,0.9288,pathogenic,-3.62,available,https://doi.org/10.1101/2022.10.22.513328 +E224Q,NP_000537:p.Glu224Gln,"hg19,17:g.7578179C>G, hg38,17:g.7674861C>G",,,0.533,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.00016,0.0187591314315795,0.01939,0.2782230576332206,0.009615,0.1390315288166103,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.1072,0.8075,-0.3564,-1.91513849442025,1.8540097530009485e-07,Benign,0.4287,ambiguous,-2.94,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E224R,NP_000537:p.Glu224Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.05559,0.2193645238876342,0.37789,0.0020434316114176,0.21674,0.0288167158057088,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2611,0.8075,-8.9599,-4.64231007967343,0.1327728796971731,Benign,0.9148,pathogenic,-3.633,available,https://doi.org/10.1101/2022.10.22.513328 +E224S,NP_000537:p.Glu224Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.10937,0.0434707999229431,0.11224,0.2587978762320164,0.110805,0.1840839381160082,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2598,0.8075,-22.2477,-5.9935915367348,0.5361025660052672,Uncertain,0.7836,pathogenic,-3.692,available,https://doi.org/10.1101/2022.10.22.513328 +E224T,NP_000537:p.Glu224Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.42199,0.1668036580085754,0.51599,0.1892333292589826,0.46898999999999996,0.3056116646294913,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2757,0.8075,-22.2477,-6.51966851149614,0.5220185943782351,Uncertain,0.8748,pathogenic,-3.976,available,https://doi.org/10.1101/2022.10.22.513328 +E224V,NP_000537:p.Glu224Val,"hg19,17:g.7578178T>A, hg38,17:g.7674860T>A",,,0.868,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35145,0.3297460079193115,0.29422,0.0359504215062306,0.322835,0.1937002107531153,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,94.54,-,-0.2596,0.8075,-22.2477,-6.31570379136526,0.3745897440488386,Uncertain,0.82,pathogenic,-3.685,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E224W,NP_000537:p.Glu224Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.26707,0.5158052444458008,-0.08707,-0.4076028371846402,-0.17706999999999998,-0.3373364185923201,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.3035,0.8075,-22.2477,-6.67883821107086,0.7915920172110541,Pathogenic,0.9972,pathogenic,-4.341,available,https://doi.org/10.1101/2022.10.22.513328 +E224Y,NP_000537:p.Glu224Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.04494,0.39024817943573,-0.81565,-0.0055574663854224,-0.385355,0.0196912668072888,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.008,,,Uncertain,,Uncertain,,,Uncertain,105.1,,True,105.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.54,-,-0.2942,0.8075,-22.2477,-6.67883821107086,0.8391804471259683,Pathogenic,0.99,pathogenic,-4.297,available,https://doi.org/10.1101/2022.10.22.513328 +V225A,NP_000537:p.Val225Ala,"hg19,17:g.7577607A>G, hg38,17:g.7674289A>G",,,0.449,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.09455,-0.2386983633041381,-0.21463,0.1133724185914508,-0.060039999999999996,0.10396120929572539,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.1915,0.8678,-6.6352,-1.53192676045706,0.0026111250186697,Benign,0.2646,benign,-3.413,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V225C,NP_000537:p.Val225Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.1109,-0.2300522923469543,0.45986,0.8780251844734557,0.28537999999999997,0.49446259223672784,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.299,0.8678,-22.2448,-4.71105889068517,0.067453485424971,Benign,0.8601,pathogenic,-4.025,available,https://doi.org/10.1101/2022.10.22.513328 +V225D,NP_000537:p.Val225Asp,"hg19,17:g.7577607A>T, hg38,17:g.7674289A>T",,,0.645,"COSMIC,ClinVar,saturation_mutlist",850916,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01805,-0.1966788172721862,-0.48639,-0.1361808922929552,-0.23417,-0.05906544614647761,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.4378,0.8678,-22.2448,-5.34716918537026,0.0696620439250769,Benign,0.6692,pathogenic,-4.042,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V225E,NP_000537:p.Val225Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.12119,-0.2303823232650756,-0.63537,-0.2805579379122397,-0.25709,-0.07968396895611984,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,94.69,T,-0.3951,0.8678,-22.2448,-5.90246190022223,0.7585363892313824,Pathogenic,0.5667,pathogenic,-4.046,available,https://doi.org/10.1101/2022.10.22.513328 +V225F,NP_000537:p.Val225Phe,"hg19,17:g.7577608C>A, hg38,17:g.7674290C>A",,,0.704,"COSMIC,ClinVar,saturation_mutlist",2122381,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01022,0.0403932332992553,0.25034,0.1201703775173201,0.13028,0.06519518875866005,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.3483,0.8678,-22.2448,-5.70657313311416,0.7050680799784068,Pathogenic,0.4754,ambiguous,-4.036,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V225G,NP_000537:p.Val225Gly,"hg38,17:g.7674289A>C",,,0.644,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30683,0.1223213076591491,0.43707,0.5602246167219712,0.37195,0.43352730836098563,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.397,0.8678,-22.2448,-5.42787583996965,0.3876821167476796,Uncertain,0.4103,ambiguous,-3.935,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V225H,NP_000537:p.Val225His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.15186,-0.065981388092041,-0.07993,-0.1288334143144159,0.035965,0.011513292842792053,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.4407,0.8678,-22.2448,-5.3819787118312,0.1620136557809015,Benign,0.8768,pathogenic,-4.018,available,https://doi.org/10.1101/2022.10.22.513328 +V225I,NP_000537:p.Val225Ile,"hg19,17:g.7577608C>T, hg38,17:g.7674290C>T",,,0.388,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480736,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.08646,-0.0352475643157959,0.09218,0.0350239274490621,0.08932,0.06074196372453105,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.1257,0.8678,-6.3721,-0.536556513058598,0.1029328274383572,Benign,0.1204,benign,-3.647,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V225K,NP_000537:p.Val225Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.05636,-0.089119017124176,-0.47993,-0.0329745247148621,-0.268145,-0.04466726235743105,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.434,0.8678,-22.2448,-5.86020722634012,0.3558527492771276,Uncertain,0.7211,pathogenic,-4.147,available,https://doi.org/10.1101/2022.10.22.513328 +V225L,NP_000537:p.Val225Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.00176,-0.0677886009216308,-0.08571,-0.0911615495049289,-0.043734999999999996,-0.04646077475246445,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.1731,0.8678,-2.9127,-1.65744017387142,7.450277810250941e-08,Benign,0.4183,ambiguous,-3.263,available,https://doi.org/10.1101/2022.10.22.513328 +V225M,NP_000537:p.Val225Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.08009,0.0093952417373657,0.42755,0.1058436811314145,0.25382,0.09296684056570725,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.2809,0.8678,-22.2448,-2.10973895472684,0.4640763297575456,Uncertain,0.3587,ambiguous,-3.764,available,https://doi.org/10.1101/2022.10.22.513328 +V225N,NP_000537:p.Val225Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.03745,-0.0066159963607788,-0.19728,0.1072299662815068,-0.07991500000000001,0.0723399831407534,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.3578,0.8678,-8.957,-2.61885085922721,0.4170886313313269,Uncertain,0.6382,pathogenic,-3.966,available,https://doi.org/10.1101/2022.10.22.513328 +V225P,NP_000537:p.Val225Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.50556,-0.4425781965255737,-1.30544,0.1468011919195894,-0.9055,-0.1793794040402053,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.3945,0.8678,-6.3721,-3.47343953537403,0.0004239223875519,Benign,0.5258,ambiguous,-3.448,available,https://doi.org/10.1101/2022.10.22.513328 +V225Q,NP_000537:p.Val225Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.03776,-0.1364704966545105,-0.22925,0.1677809048051703,-0.095745,0.10277045240258514,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,94.69,T,-0.4057,0.8678,-22.2448,-5.90246190022223,0.7553740163047278,Pathogenic,0.6754,pathogenic,-4.044,available,https://doi.org/10.1101/2022.10.22.513328 +V225R,NP_000537:p.Val225Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.04667,-0.0053867101669311,0.02959,-0.0170619398576543,0.038130000000000004,0.014804030071172852,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.3872,0.8678,-8.957,-4.22105053032847,0.2480025335352462,Benign,0.6581,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +V225S,NP_000537:p.Val225Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.18744,-0.1703315377235412,-0.37517,0.0080649755134953,-0.093865,0.09775248775674765,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.3748,0.8678,-22.2448,-4.12317779642017,0.0036450640012343,Benign,0.538,ambiguous,-3.722,available,https://doi.org/10.1101/2022.10.22.513328 +V225T,NP_000537:p.Val225Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.03774,-0.0009284019470214,-0.28741,0.0553917001684306,-0.162575,0.008825850084215298,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.2902,0.8678,-22.2448,-4.12789470862988,0.0298198797391941,Benign,0.3814,ambiguous,-3.638,available,https://doi.org/10.1101/2022.10.22.513328 +V225W,NP_000537:p.Val225Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.09759,-0.0121673941612243,0.58605,-0.2806252566743306,0.24422999999999997,-0.1891076283371653,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.3889,0.8678,-22.2448,-5.70657313311416,0.7350077310600601,Pathogenic,0.9312,pathogenic,-4.417,available,https://doi.org/10.1101/2022.10.22.513328 +V225Y,NP_000537:p.Val225Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.02401,0.0198126435279846,-0.01497,0.0457345897415339,0.00452,0.03487229487076695,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.016,,,Uncertain,,Uncertain,,,Uncertain,118.6,,True,118.6,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.69,T,-0.3918,0.8678,-22.2448,-5.70657313311416,0.8049462602084301,Pathogenic,0.8257,pathogenic,-4.17,available,https://doi.org/10.1101/2022.10.22.513328 +G226A,NP_000537:p.Gly226Ala,"hg19,17:g.7577604C>G, hg38,17:g.7674286C>G",,,0.767,"COSMIC,ClinVar,saturation_mutlist",951459,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.80056,0.9769594073295592,1.63197,2.252065778618673,2.716265,3.0263128893093363,Uncertain,Uncertain,Neutral,Uncertain,Destabilizing,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.3023,0.1477,-8.9511,-2.4820308572667,0.4283098310503548,Uncertain,0.7389,pathogenic,-3.864,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G226C,NP_000537:p.Gly226Cys,"hg38,17:g.7674287C>A",,,0.877,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.86091,0.5666446685791016,2.09014,2.421606437968796,2.975525,3.1412582189843983,Uncertain,Uncertain,Neutral,Uncertain,Destabilizing,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.4298,0.1477,-22.239,-6.34851394065188,0.7837776573565471,Pathogenic,0.8709,pathogenic,-4.245,available,https://doi.org/10.1101/2022.10.22.513328 +G226D,NP_000537:p.Gly226Asp,"hg19,17:g.7577604C>T, hg38,17:g.7674286C>T",,,0.698,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.97422,0.8912496566772461,0.7068,1.468867357287374,2.34051,2.721543678643687,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.3523,0.1477,-6.9513,-2.41477542882087,0.320013766783454,Benign,0.8313,pathogenic,-3.982,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G226E,NP_000537:p.Gly226Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.93097,0.9585447907447816,1.39218,1.9308602748719743,2.661575,2.930915137435987,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.3619,0.1477,-8.9511,-2.40860232352943,0.4628142345976547,Uncertain,0.921,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328 +G226F,NP_000537:p.Gly226Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.84482,1.0263936519622805,0.92823,1.7079176073888036,2.386525,2.776368803694402,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.4679,0.1477,-22.239,-7.34453480461727,0.8627807594418364,Pathogenic,0.9651,pathogenic,-4.573,available,https://doi.org/10.1101/2022.10.22.513328 +G226H,NP_000537:p.Gly226His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.97569,0.9335501194000244,0.83163,1.353304056047772,2.40366,2.664497028023886,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.4427,0.1477,-22.239,-7.34453480461727,0.8444038723266388,Pathogenic,0.9737,pathogenic,-4.391,available,https://doi.org/10.1101/2022.10.22.513328 +G226I,NP_000537:p.Gly226Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.8802,1.3827927112579346,5.43776,3.0655968866439784,5.15898,3.9728984433219896,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.5136,0.1477,-22.239,-7.59947433762722,0.8639690646442839,Pathogenic,0.9627,pathogenic,-4.538,available,https://doi.org/10.1101/2022.10.22.513328 +G226K,NP_000537:p.Gly226Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.83754,1.141277551651001,1.27653,1.754626895150532,2.557035,2.796083447575266,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.4626,0.1477,-22.239,-7.59947433762722,0.8659414183133936,Pathogenic,0.9898,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +G226L,NP_000537:p.Gly226Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.91153,1.121617078781128,1.59456,1.7125618823888973,2.753045,2.8120459411944485,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.4818,0.1477,-22.239,-7.59947433762722,0.8608623076180737,Pathogenic,0.9563,pathogenic,-4.516,available,https://doi.org/10.1101/2022.10.22.513328 +G226M,NP_000537:p.Gly226Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.8082,1.078341722488403,2.09694,1.809141481068684,2.9525699999999997,2.808670740534342,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.42,0.1477,-22.239,-7.59947433762722,0.856335066399476,Pathogenic,0.9771,pathogenic,-4.496,available,https://doi.org/10.1101/2022.10.22.513328 +G226N,NP_000537:p.Gly226Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.8467,0.8143637776374817,0.41122,1.2514822080226895,2.1289599999999997,2.5490911040113446,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.4307,0.1477,-22.239,-6.34851394065188,0.8511342835267011,Pathogenic,0.9234,pathogenic,-4.269,available,https://doi.org/10.1101/2022.10.22.513328 +G226P,NP_000537:p.Gly226Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.38435,1.3201110363006592,2.65374,6.70891144308795,4.519045,6.546630721543975,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.5277,0.1477,-22.239,-7.59947433762722,0.8703754082036055,Pathogenic,0.9802,pathogenic,-4.315,available,https://doi.org/10.1101/2022.10.22.513328 +G226Q,NP_000537:p.Gly226Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.87847,1.1237777471542358,1.45884,1.9552744380320413,2.668655,2.9168722190160206,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.4336,0.1477,-22.239,-5.68301129149202,0.5488300912519878,Uncertain,0.9641,pathogenic,-4.158,available,https://doi.org/10.1101/2022.10.22.513328 +G226R,NP_000537:p.Gly226Arg,,,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.70937,1.088978290557861,1.50884,1.627923338206917,2.609105,2.6686466691034583,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.4466,0.1477,-22.239,-7.59947433762722,0.764258778073929,Pathogenic,0.9674,pathogenic,-4.172,available,https://doi.org/10.1101/2022.10.22.513328 +G226S,NP_000537:p.Gly226Ser,"hg19,17:g.7577605C>T, hg38,17:g.7674287C>T",,,0.866,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",648028,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.93968,1.02079439163208,1.27721,1.931393852781332,2.608445,2.935536926390666,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.3031,0.1477,-7.9512,-3.82207883968178,0.0915108755976376,Benign,0.6868,pathogenic,-3.618,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G226T,NP_000537:p.Gly226Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.10509,1.2215410470962524,1.52279,2.712076646763796,3.3139399999999997,3.908583323381898,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.4529,0.1477,-22.239,-6.34851394065188,0.864340875913082,Pathogenic,0.8934,pathogenic,-4.276,available,https://doi.org/10.1101/2022.10.22.513328 +G226V,NP_000537:p.Gly226Val,"hg19,17:g.7577604C>A, hg38,17:g.7674286C>A",,,0.838,"COSMIC,ClinVar,saturation_mutlist",458556,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.00566,1.3835842609405518,5.49388,2.9324367054827487,5.24977,3.9690483527413742,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.4569,0.1477,-22.239,-7.59947433762722,0.8515373455916199,Pathogenic,0.9277,pathogenic,-4.433,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G226W,NP_000537:p.Gly226Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.84808,1.1640303134918213,1.58537,1.5472335901830296,2.716725,2.6976567950915147,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.4677,0.1477,-22.239,-7.34453480461727,0.8640085379666791,Pathogenic,0.9538,pathogenic,-4.568,available,https://doi.org/10.1101/2022.10.22.513328 +G226Y,NP_000537:p.Gly226Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.85777,1.084034442901611,0.96224,1.7803190216170457,2.410005,2.819044510808523,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,118.9,,True,118.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.84,T,-0.4683,0.1477,-22.239,-7.34453480461727,0.8235173554497044,Pathogenic,0.9577,pathogenic,-4.548,available,https://doi.org/10.1101/2022.10.22.513328 +S227A,NP_000537:p.Ser227Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.04833,-0.1589243412017822,0.65918,-0.1298719173144358,0.853755,0.4592290413427821,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,94.06,-,-0.0681,1.345,-4.8638,-0.805629688252832,6.614483750537567e-05,Benign,0.0991,benign,-3.146,available,https://doi.org/10.1101/2022.10.22.513328 +S227C,NP_000537:p.Ser227Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.27238,-0.4256773591041565,1.13163,0.5824380349839292,1.202005,0.9274090174919647,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.1292,1.345,-6.9513,-1.01244842519811,3.81532446597354e-06,Benign,0.1364,benign,-3.21,available,https://doi.org/10.1101/2022.10.22.513328 +S227D,NP_000537:p.Ser227Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.50224,0.1902295053005218,1.7415,0.3483943961629676,1.62187,0.9253171980814838,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.2554,1.345,-22.239,-5.09404086805612,0.2450659360866122,Benign,0.8405,pathogenic,-3.865,available,https://doi.org/10.1101/2022.10.22.513328 +S227E,NP_000537:p.Ser227Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.50307,-0.0977709293365478,1.13265,0.1155370248183074,1.31786,0.8093035124091537,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.2286,1.345,-22.239,-5.1589504096365,0.1648821851491781,Benign,0.8379,pathogenic,-3.732,available,https://doi.org/10.1101/2022.10.22.513328 +S227F,NP_000537:p.Ser227Phe,"hg19,17:g.7577601G>A, hg38,17:g.7674283G>A",,,0.727,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3634429,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.93416,-0.2253694534301757,0.24558,-0.8862780905681822,0.58987,0.023940954715908902,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.2348,1.345,-22.239,-6.80108941624029,0.5169494030222255,Uncertain,0.548,ambiguous,-4.088,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S227G,NP_000537:p.Ser227Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.6783,0.182317167520523,1.86565,0.8868428773520576,1.7719749999999999,1.2825714386760287,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,94.06,-,-0.1659,1.345,-22.239,-6.80108941624029,0.1603026045290813,Benign,0.2313,benign,-3.619,available,https://doi.org/10.1101/2022.10.22.513328 +S227H,NP_000537:p.Ser227His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.11247,-0.3995237946510315,0.63639,-0.5590689166238455,1.37443,0.7767005416880772,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.236,1.345,-22.239,-6.80108941624029,0.7210515835217852,Pathogenic,0.8233,pathogenic,-3.961,available,https://doi.org/10.1101/2022.10.22.513328 +S227I,NP_000537:p.Ser227Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.73075,0.2429245710372924,0.42109,-0.4066001851693002,1.57592,1.16207490741535,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.2379,1.345,-22.239,-5.04149545590972,0.6958010218157198,Pathogenic,0.6695,pathogenic,-3.912,available,https://doi.org/10.1101/2022.10.22.513328 +S227K,NP_000537:p.Ser227Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.01465,-0.1923425793647766,-0.11327,-0.2292218388991451,0.45069000000000004,0.39271408055042745,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.2453,1.345,-22.239,-5.94438103249811,0.3232824927551385,Uncertain,0.9701,pathogenic,-3.827,available,https://doi.org/10.1101/2022.10.22.513328 +S227L,NP_000537:p.Ser227Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.73264,-0.1762818098068237,0.06701,-1.04346075556784,0.399825,-0.15541037778391997,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.1583,1.345,-7.3663,-3.58515710816714,0.0633611642811143,Benign,0.2155,benign,-3.596,available,https://doi.org/10.1101/2022.10.22.513328 +S227M,NP_000537:p.Ser227Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.23245,-0.165114164352417,0.26463,-0.6313777556055566,0.74854,0.3005361221972217,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.1293,1.345,-7.3663,-3.63745873597621,0.0008267247925185,Benign,0.3528,ambiguous,-3.417,available,https://doi.org/10.1101/2022.10.22.513328 +S227N,NP_000537:p.Ser227Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42859,-0.260491669178009,1.00272,-0.0873317886375346,1.215655,0.6706291056812327,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.179,1.345,-22.239,-5.11015122727727,0.1345326634030338,Benign,0.6008,pathogenic,-3.541,available,https://doi.org/10.1101/2022.10.22.513328 +S227P,NP_000537:p.Ser227Pro,"hg19,17:g.7577602A>G, hg38,17:g.7674284A>G",,,0.681,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.06059,1.1700830459594729,5.2119,2.2419520065020726,4.136245,2.6512710032510363,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.2424,1.345,-8.9511,-6.22351859774356,0.355718710316241,Uncertain,0.9492,pathogenic,-3.754,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S227Q,NP_000537:p.Ser227Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.40437,-0.2193871140480041,0.49116,-0.1412320356492619,0.947765,0.6315689821753689,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.1987,1.345,-22.239,-5.00815519311386,0.0689674953125924,Benign,0.8402,pathogenic,-3.577,available,https://doi.org/10.1101/2022.10.22.513328 +S227R,NP_000537:p.Ser227Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.23493,-0.1528038382530212,0.2119,-0.7081143349226227,0.723415,0.2634078325386887,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.2506,1.345,-22.239,-5.128498872062,0.4838141642636629,Uncertain,0.9478,pathogenic,-3.827,available,https://doi.org/10.1101/2022.10.22.513328 +S227T,NP_000537:p.Ser227Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.60859,-0.0108985900878906,0.59966,0.1342355010590246,1.104125,0.8714127505295123,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,neutral,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.0379,1.345,-0.7714,-1.99749882559897,5.062022763145958e-06,Benign,0.1425,benign,-3.09,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S227V,NP_000537:p.Ser227Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.38858,0.1687200665473938,0.33844,-0.1962497259721279,0.86351,0.596165137013936,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.1393,1.345,-7.9512,-3.20135293169315,0.0123084491376646,Benign,0.4741,ambiguous,-3.446,available,https://doi.org/10.1101/2022.10.22.513328 +S227W,NP_000537:p.Ser227Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.23504,-0.0129064917564392,0.41599,-1.2171546929171972,0.825515,0.008942653541401335,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.2445,1.345,-22.239,-6.80108941624029,0.7220692719177828,Pathogenic,0.6894,pathogenic,-4.29,available,https://doi.org/10.1101/2022.10.22.513328 +S227Y,NP_000537:p.Ser227Tyr,"hg38,17:g.7674283G>T",,,0.772,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.9228,-0.2046023607254028,0.1085,-0.7360570091620228,0.5156499999999999,0.09337149541898859,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.024,,,Uncertain,,Uncertain,,,Uncertain,44.2,,True,44.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,94.06,-,-0.2396,1.345,-22.239,-6.80108941624029,0.6497256359529086,Uncertain,0.5655,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228A,NP_000537:p.Asp228Ala,"hg38,17:g.7674280T>G",,,0.758,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28332,0.2773087620735168,0.29388,0.4269785441787038,0.28859999999999997,0.3551492720893519,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.176,1.011,-6.6293,-3.7265271431836,0.0001063103091481,Benign,0.1645,benign,-3.388,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228C,NP_000537:p.Asp228Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.39843,0.0466113090515136,0.97279,0.9987452192934332,0.68561,0.6985876096467166,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.35,S,-0.2971,1.011,-22.239,-5.67654552150741,0.4215506801883402,Uncertain,0.5232,ambiguous,-4.036,available,https://doi.org/10.1101/2022.10.22.513328 +D228E,NP_000537:p.Asp228Glu,"hg19,17:g.7577597G>C, hg19,17:g.7577597G>T, hg19,17:g.7674279G>C, hg38,17:g.7674279G>C, hg38,17:g.7674279G>T",,,"0.370, 0.371","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","954848, 926556","Uncertain significance, Conflicting classifications of pathogenicity","1, 1",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.00559,0.4381983876228332,-0.07245,0.0967224005998002,-0.03902,0.0455662002999001,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.0891,1.011,-0.3967,-0.386789767388704,3.16387615778233e-08,Benign,0.1188,benign,-2.846,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228F,NP_000537:p.Asp228Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28958,0.3969883918762207,0.34048,0.0356382853199971,0.31503000000000003,0.16260914265999854,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.3558,1.011,-22.239,-5.58592152223596,0.1359111735954219,Benign,0.595,pathogenic,-4.01,available,https://doi.org/10.1101/2022.10.22.513328 +D228G,NP_000537:p.Asp228Gly,"hg38,17:g.7674280T>C",,,0.704,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.5742,0.3716509938240051,0.76327,0.8105606337246574,0.6687350000000001,0.6923803168623287,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.1872,1.011,-6.6293,-3.623202403396,0.0002047575792239,Benign,0.1774,benign,-3.453,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228H,NP_000537:p.Asp228His,"hg19,17:g.7577599C>G, hg38,17:g.7674281C>G",,,0.777,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.44857,0.3024264574050903,0.13878,-0.0923606540384158,0.293675,0.1781046729807921,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.265,1.011,-22.239,-6.0681896198295,0.1972400103681589,Benign,0.2979,benign,-3.758,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228I,NP_000537:p.Asp228Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.58223,0.5663189888000488,1.01327,0.4212660323295447,0.79775,0.5017480161647724,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.348,1.011,-22.239,-6.12964452449616,0.3635848832643872,Uncertain,0.3822,ambiguous,-3.947,available,https://doi.org/10.1101/2022.10.22.513328 +D228K,NP_000537:p.Asp228Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.04868,0.4531372189521789,-0.06395,0.2206500256752386,-0.056315000000000004,0.08598501283761929,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.2586,1.011,-8.9511,-4.2170016269923,0.0016744894807784,Benign,0.3821,ambiguous,-3.604,available,https://doi.org/10.1101/2022.10.22.513328 +D228L,NP_000537:p.Asp228Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.0925,0.5327821373939514,-0.16293,-0.0694080496353499,-0.035214999999999996,0.011545975182325051,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.2688,1.011,-7.9512,-3.79169604443584,0.0002510157559784,Benign,0.3685,ambiguous,-3.578,available,https://doi.org/10.1101/2022.10.22.513328 +D228M,NP_000537:p.Asp228Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.13849,0.4957002997398376,0.46939,0.3397545474520463,0.30394,0.23912227372602315,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.2804,1.011,-22.239,-6.12964452449616,0.3249010820710045,Uncertain,0.5882,pathogenic,-4.029,available,https://doi.org/10.1101/2022.10.22.513328 +D228N,NP_000537:p.Asp228Asn,"hg19,17:g.7577599C>T, hg19,17:g.7674281C>T, hg38,17:g.7674281C>T",,,0.546,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1395667,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.11809,0.1846802830696106,-0.17959,0.0943138430162332,-0.03075,0.10620192150811661,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.35,S,-0.2224,1.011,-22.239,-3.63637678595156,0.0094055721676452,Benign,0.1058,benign,-3.574,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228P,NP_000537:p.Asp228Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.41194,0.9105285406112672,0.11293,1.6789703107413083,-0.149505,0.6335151553706542,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.35,S,-0.3926,1.011,-22.239,-6.1765366523254,0.0182640026734036,Benign,0.521,ambiguous,-3.825,available,https://doi.org/10.1101/2022.10.22.513328 +D228Q,NP_000537:p.Asp228Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.03858,0.3318791389465332,0.03844,0.4261725100789382,0.03851,0.2323762550394691,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.2148,1.011,-8.9511,-1.94650618887419,0.0005556825151301,Benign,0.2977,benign,-3.441,available,https://doi.org/10.1101/2022.10.22.513328 +D228R,NP_000537:p.Asp228Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2177,0.5333117842674255,0.25204,0.1856241304966038,0.01716999999999999,-0.016037934751698096,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.3574,1.011,-22.239,-5.53340521485805,0.0733103979600607,Benign,0.3934,ambiguous,-3.782,available,https://doi.org/10.1101/2022.10.22.513328 +D228S,NP_000537:p.Asp228Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.38047,0.0631496906280517,0.16327,0.364251081997719,0.27187,0.3723605409988595,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.2621,1.011,-22.239,-4.69043179375549,0.0858854092707639,Benign,0.1199,benign,-3.573,available,https://doi.org/10.1101/2022.10.22.513328 +D228T,NP_000537:p.Asp228Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.63054,0.2545656561851501,0.27279,0.3689281901555169,0.451665,0.49973409507775846,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.35,S,-0.2243,1.011,-8.9511,-4.99354423711014,0.003621983495045,Benign,0.2187,benign,-3.628,available,https://doi.org/10.1101/2022.10.22.513328 +D228V,NP_000537:p.Asp228Val,"hg38,17:g.7674280T>A",,,0.829,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.4127,0.6114094257354736,-0.32381,0.3865083851389073,0.04444500000000001,0.3996041925694537,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.2349,1.011,-8.9511,-4.70414434620379,0.0299265138600162,Benign,0.238,benign,-3.512,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D228W,NP_000537:p.Asp228Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.55583,0.4399691224098205,0.88027,-0.2655407320014613,0.7180500000000001,0.14514463399926938,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.3362,1.011,-22.239,-6.32011535407786,0.5408863750944581,Uncertain,0.8591,pathogenic,-4.241,available,https://doi.org/10.1101/2022.10.22.513328 +D228Y,NP_000537:p.Asp228Tyr,"hg19,17:g.7577599C>A, hg38,17:g.7674281C>A",,,0.849,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2450759,Likely benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.40465,0.4781718254089355,0.10408,0.1251217243272956,0.254365,0.2648858621636478,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,,,Uncertain,,Uncertain,,,Uncertain,78.7,,True,78.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.35,S,-0.3007,1.011,-22.239,-6.32011535407786,0.7322515131696187,Pathogenic,0.3148,benign,-4.14,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C229A,NP_000537:p.Cys229Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.09814,0.1595528125762939,0.03469,0.831766038230309,-0.031725,0.3668130191151545,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.04,S,-0.2384,1.9363,-7.3604,-1.82769194347323,0.0020902398359971,Benign,0.495,ambiguous,-3.37,available,https://doi.org/10.1101/2022.10.22.513328 +C229D,NP_000537:p.Cys229Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.48549,1.154924750328064,1.80238,1.5973032866278472,1.643935,1.5413966433139237,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.04,S,-0.4216,1.9363,-22.2332,-3.51317249077547,0.0894574346804364,Benign,0.7967,pathogenic,-4.036,available,https://doi.org/10.1101/2022.10.22.513328 +C229E,NP_000537:p.Cys229Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.09003,1.091722011566162,2.22381,1.7107621698845366,1.65692,1.4003960849422683,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.4092,1.9363,-22.2332,-3.90977940080524,0.0846914174269106,Benign,0.8604,pathogenic,-3.93,available,https://doi.org/10.1101/2022.10.22.513328 +C229F,NP_000537:p.Cys229Phe,"hg19,17:g.7577595C>A, hg38,17:g.7674277C>A",,,0.401,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.45862,0.0573810338973999,-1.46156,-0.9452681664556556,-1.46009,-1.2019440832278279,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.1987,1.9363,-0.7606,-0.9953252826484,5.3352857883834094e-05,Benign,0.1155,benign,-3.154,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C229G,NP_000537:p.Cys229Gly,"hg19,17:g.7577596A>C, hg38,17:g.7674278A>C",,,0.738,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1026715,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.39895,0.8169935941696167,1.70442,2.06959961245452,1.051685,1.2342748062272602,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.04,S,-0.2246,1.9363,-6.1381,-2.85968821708073,0.0002614157557203,Benign,0.2485,benign,-3.472,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C229H,NP_000537:p.Cys229His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.85051,0.0019478797912597,0.10714,0.2888270560730099,0.478825,0.5696685280365049,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.3441,1.9363,-7.3604,-1.27444965076117,0.0007008657332372,Benign,0.437,ambiguous,-3.449,available,https://doi.org/10.1101/2022.10.22.513328 +C229I,NP_000537:p.Cys229Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.60621,0.3367525935173034,0.61395,-0.0042873069703158,2.61008,2.300961346514842,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.2527,1.9363,-5.486,-2.19947137977006,0.004808843010535,Benign,0.5593,ambiguous,-3.584,available,https://doi.org/10.1101/2022.10.22.513328 +C229K,NP_000537:p.Cys229Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.20983,0.3854184150695801,1.97041,2.2213328099347,1.09012,1.2155814049673501,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.4098,1.9363,-22.2332,-4.61929382670825,0.1749814866774836,Benign,0.8663,pathogenic,-3.946,available,https://doi.org/10.1101/2022.10.22.513328 +C229L,NP_000537:p.Cys229Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.55639,0.6589502096176147,-0.06497,0.0904814928075603,0.24571000000000004,0.32343574640378014,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.3712,1.9363,-22.2332,-2.82853841523471,0.0099001091902112,Benign,0.6073,pathogenic,-3.418,available,https://doi.org/10.1101/2022.10.22.513328 +C229M,NP_000537:p.Cys229Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.75599,0.5689035654067993,0.46497,0.4450179786532138,-0.14551000000000003,-0.15548601067339313,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.2498,1.9363,-4.858,-2.21619368941055,0.0005552331939442,Benign,0.6412,pathogenic,-3.565,available,https://doi.org/10.1101/2022.10.22.513328 +C229N,NP_000537:p.Cys229Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.61923,0.6338855624198914,0.53333,0.8933722236989905,0.5762799999999999,0.7563011118494952,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.2962,1.9363,-8.9453,-2.78368040727698,0.0025004147659933,Benign,0.5546,ambiguous,-3.708,available,https://doi.org/10.1101/2022.10.22.513328 +C229P,NP_000537:p.Cys229Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.38901,1.0179601907730105,5.52551,5.007057726263271,3.9572599999999998,3.6980338631316356,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.04,S,-0.4326,1.9363,-22.2332,-3.78261747030186,0.277559208730174,Benign,0.9701,pathogenic,-3.92,available,https://doi.org/10.1101/2022.10.22.513328 +C229Q,NP_000537:p.Cys229Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.34018,0.4077499508857727,1.03197,1.0436125353709014,0.686075,0.6918962676854506,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.388,1.9363,-22.2332,-4.30447399895388,0.6042874337545499,Uncertain,0.6854,pathogenic,-3.925,available,https://doi.org/10.1101/2022.10.22.513328 +C229R,NP_000537:p.Cys229Arg,"hg19,17:g.7577596A>G, hg38,17:g.7674278A>G",,7.9529819706e-06,0.754,"COSMIC,ClinVar,saturation_mutlist",420137,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.45855,0.3950808048248291,0.90782,1.3133802639929275,0.6831849999999999,0.8859651319964638,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.2937,1.9363,-7.9454,-3.21722478031866,0.0125933605659176,Benign,0.5548,ambiguous,-3.591,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C229S,NP_000537:p.Cys229Ser,"hg19,17:g.7577595C>G, hg19,17:g.7577596A>T, hg38,17:g.7674277C>G, hg38,17:g.7674278A>T",,,"0.535, 0.600","cBioPortal,COSMIC,ClinVar,saturation_mutlist",582302,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.88696,0.1727092862129211,0.85646,1.465064849360837,0.87171,1.1760124246804184,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.04,S,-0.2196,1.9363,-5.486,-1.48349505430365,0.0001062543235567,Benign,0.2846,benign,-3.098,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C229T,NP_000537:p.Cys229Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28647,0.2986549139022827,0.67143,0.9282029500408584,0.47895,0.6073364750204292,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.2639,1.9363,-7.3604,-1.51271884520354,5.5648685070912027e-05,Benign,0.5127,ambiguous,-3.35,available,https://doi.org/10.1101/2022.10.22.513328 +C229V,NP_000537:p.Cys229Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.75217,-0.0081449747085571,0.70578,0.1200162357283107,1.228975,0.9360931178641554,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.2633,1.9363,-7.9454,-2.35478821914342,0.0023236333267171,Benign,0.4695,ambiguous,-3.472,available,https://doi.org/10.1101/2022.10.22.513328 +C229W,NP_000537:p.Cys229Trp,"hg19,17:g.7577594A>C",,,0.594,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.91845,0.2740243673324585,-1.02347,-0.4769108787448239,-0.97096,-0.697680439372412,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.2304,1.9363,-6.3605,-1.05331855646119,0.005445517137338,Benign,0.3728,ambiguous,-3.472,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C229Y,NP_000537:p.Cys229Tyr,"hg19,17:g.7577595C>T, hg38,17:g.7674277C>T",,,0.389,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",419040,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.05452,-0.0486572980880737,-1.43673,-0.5701797823290683,-1.245625,-0.8123498911645342,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.081,,,,,,,,,9.4,,False,9.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.04,S,-0.2267,1.9363,-4.4219,0.0338896257398098,3.77156937776905e-07,Benign,0.1447,benign,-3.098,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T230A,NP_000537:p.Thr230Ala,"hg19,17:g.7577593T>C, hg38,17:g.7674275T>C",,,0.856,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",953956,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.05322,1.2944800853729248,0.76973,0.6411671727429771,0.911475,0.8471935863714886,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,96.63,E,-0.2241,0.2248,-6.9513,-0.771978531034543,0.4226653637066954,Uncertain,0.1821,benign,-3.662,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T230C,NP_000537:p.Thr230Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.93053,0.8282055854797363,1.00238,1.1258392198943572,0.9664550000000001,1.0281846099471785,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,96.63,E,-0.3379,0.2248,-22.239,-4.25734855828884,0.7304015856328429,Pathogenic,0.5563,ambiguous,-4.054,available,https://doi.org/10.1101/2022.10.22.513328 +T230D,NP_000537:p.Thr230Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.34359,2.80260968208313,2.29252,1.6792040466877136,2.318055,2.0113970233438567,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,96.63,E,-0.4177,0.2248,-22.239,-5.19335573052498,0.8593369385210501,Pathogenic,0.9573,pathogenic,-4.49,available,https://doi.org/10.1101/2022.10.22.513328 +T230E,NP_000537:p.Thr230Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.17554,2.281486749649048,2.20204,1.3540585908626672,1.68879,1.2647992954313336,Uncertain,Neutral,Destabilizing,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,96.63,E,-0.393,0.2248,-22.239,-6.41578450221753,0.7896261498533217,Pathogenic,0.9391,pathogenic,-4.35,available,https://doi.org/10.1101/2022.10.22.513328 +T230F,NP_000537:p.Thr230Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.86145,1.1794559955596924,-0.93027,-1.4635780568821215,-1.39586,-1.6625140284410609,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,96.63,E,-0.4094,0.2248,-22.239,-5.25335794905371,0.2875419588663445,Benign,0.804,pathogenic,-4.061,available,https://doi.org/10.1101/2022.10.22.513328 +T230G,NP_000537:p.Thr230Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.77194,2.187384605407715,2.42415,2.1724090685999045,2.598045,2.472174534299952,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,96.63,E,-0.3756,0.2248,-22.239,-7.26080279635167,0.8576741900955198,Pathogenic,0.7016,pathogenic,-4.386,available,https://doi.org/10.1101/2022.10.22.513328 +T230H,NP_000537:p.Thr230His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.83716,1.4779222011566162,0.70544,-0.0964820639335228,0.7713,0.3703389680332386,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,96.63,E,-0.3896,0.2248,-22.239,-6.15585463465824,0.8296370399299109,Pathogenic,0.7994,pathogenic,-4.388,available,https://doi.org/10.1101/2022.10.22.513328 +T230I,NP_000537:p.Thr230Ile,"hg19,17:g.7577592G>A, hg38,17:g.7674274G>A",,,0.936,"COSMIC,ClinVar,saturation_mutlist",1366616,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.08963,0.3910783529281616,0.38844,-0.0820923082143332,0.149405,-0.0858611541071666,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,96.63,E,-0.2551,0.2248,-7.9512,-2.85517953282881,0.0265049262488396,Benign,0.669,pathogenic,-3.625,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T230K,NP_000537:p.Thr230Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.52901,0.9721415638923644,0.72925,0.9352917305614356,0.10011999999999999,0.2031408652807178,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,96.63,E,-0.3852,0.2248,-22.239,-6.46390158073096,0.7455115628828646,Pathogenic,0.9088,pathogenic,-4.272,available,https://doi.org/10.1101/2022.10.22.513328 +T230L,NP_000537:p.Thr230Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.29093,1.353667974472046,-0.26497,-0.3190619408174305,-0.7779499999999999,-0.8049959704087152,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,96.63,E,-0.3799,0.2248,-22.239,-5.33684486116727,0.7988843562123162,Pathogenic,0.4796,ambiguous,-4.192,available,https://doi.org/10.1101/2022.10.22.513328 +T230M,NP_000537:p.Thr230Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.98593,1.1017266511917114,-0.20986,0.1126030227232266,-1.097895,-0.9366634886383867,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,96.63,E,-0.3469,0.2248,-22.239,-4.53851018335458,0.5166988321194547,Uncertain,0.2973,benign,-3.968,available,https://doi.org/10.1101/2022.10.22.513328 +T230N,NP_000537:p.Thr230Asn,"hg38,17:g.7674274G>T",,,0.875,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.46969,1.7802183628082275,1.2949,0.7873305470370897,1.382295,1.1285102735185448,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,96.63,E,-0.3577,0.2248,-22.239,-5.17123924654819,0.6687951994826158,Uncertain,0.6742,pathogenic,-4.151,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T230P,NP_000537:p.Thr230Pro,"hg19,17:g.7577593T>G, hg19,17:g.7674275T>G, hg38,17:g.7674275T>G",,,0.920,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",4539743,,,Uncertain significance,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.44769,2.5358386039733887,1.94762,5.168358074021626,1.697655,3.3080240370108127,Neutral,Uncertain,Destabilizing,Neutral,Destabilizing,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,96.63,E,-0.4664,0.2248,-22.239,-7.26080279635167,0.8692590936818427,Pathogenic,0.8389,pathogenic,-4.396,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T230Q,NP_000537:p.Thr230Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.58085,1.6162254810333252,1.47857,0.9655883704189804,1.02971,0.7732191852094902,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,96.63,E,-0.3672,0.2248,-22.239,-6.07847053462105,0.4718694486383499,Uncertain,0.8123,pathogenic,-4.157,available,https://doi.org/10.1101/2022.10.22.513328 +T230R,NP_000537:p.Thr230Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.16423,0.5388466119766235,1.0881,0.167428930297076,0.6261650000000001,0.165829465148538,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,96.63,E,-0.388,0.2248,-22.239,-5.82084561380598,0.7403451958682002,Pathogenic,0.8243,pathogenic,-4.264,available,https://doi.org/10.1101/2022.10.22.513328 +T230S,NP_000537:p.Thr230Ser,"hg19,17:g.7577593T>A, hg38,17:g.7674275T>A",,,0.863,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.39546,0.8909193277359009,1.02857,1.334684229245086,1.212015,1.365072114622543,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,neutral,,,DOWN,destabilizing,neutral,False,neutral,neutral,96.63,E,-0.1827,0.2248,-5.9513,-1.94343831854702,2.9945201892759925e-05,Benign,0.2275,benign,-3.412,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T230V,NP_000537:p.Thr230Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01646,0.2728861570358276,-0.51361,-0.0616380834622914,-0.265035,-0.0390490417311457,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,96.63,E,-0.3156,0.2248,-22.239,-4.2037386574677,0.236102291201075,Benign,0.4128,ambiguous,-3.646,available,https://doi.org/10.1101/2022.10.22.513328 +T230W,NP_000537:p.Thr230Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-2.13416,1.6553292274475098,-1.61054,-1.467272488913007,-1.87235,-1.8007162444565035,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,96.63,E,-0.4023,0.2248,-22.239,-6.15585463465824,0.8473940187197,Pathogenic,0.9531,pathogenic,-4.703,available,https://doi.org/10.1101/2022.10.22.513328 +T230Y,NP_000537:p.Thr230Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.38493,1.2754286527633667,-0.8398,-1.3461741934478526,-1.112365,-1.3655520967239263,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.162,,,,,,,,,19.0,,False,19.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,96.63,E,-0.4108,0.2248,-22.239,-4.43625447924018,0.1781627354344928,Benign,0.8651,pathogenic,-4.183,available,https://doi.org/10.1101/2022.10.22.513328 +T231A,NP_000537:p.Thr231Ala,"hg19,17:g.7577590T>C, hg38,17:g.7674272T>C",,,0.905,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",863153,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.03851,1.0987753868103027,0.83605,0.8315997200765604,0.43728,0.4350548600382802,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,96.93,E,-0.3092,0.1477,-22.239,-0.750209573914153,0.3286726156404574,Uncertain,0.4094,ambiguous,-3.625,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T231C,NP_000537:p.Thr231Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.48955,0.3352341651916504,0.94898,1.1375932012198142,0.22971500000000003,0.32402160060990715,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,96.93,E,-0.345,0.1477,-22.239,-4.69457965984154,0.8665508989929763,Pathogenic,0.8882,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328 +T231D,NP_000537:p.Thr231Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.5319,1.7568809986114502,1.13673,1.1415343373635618,0.834315,0.8367171686817809,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,96.93,E,-0.4248,0.1477,-22.239,-6.71297729684607,0.5255867794954983,Uncertain,0.9622,pathogenic,-4.244,available,https://doi.org/10.1101/2022.10.22.513328 +T231E,NP_000537:p.Thr231Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.21425,0.977540135383606,-0.00068,0.7384309751253528,0.10678499999999999,0.47634048756267644,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.93,E,-0.4001,0.1477,-22.239,-6.47717403267022,0.3806608278917238,Uncertain,0.9355,pathogenic,-4.198,available,https://doi.org/10.1101/2022.10.22.513328 +T231F,NP_000537:p.Thr231Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.05414,0.3686012029647827,-0.74014,-0.108173867062617,-0.39714,-0.0811569335313085,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.93,E,-0.4165,0.1477,-22.239,-6.44258281894111,0.789012916864202,Pathogenic,0.9004,pathogenic,-4.186,available,https://doi.org/10.1101/2022.10.22.513328 +T231G,NP_000537:p.Thr231Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.96215,2.1222355365753174,2.21871,2.432776543017359,1.59043,1.6974632715086795,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,96.93,E,-0.3827,0.1477,-22.239,-7.80657835516367,0.8252082320998753,Pathogenic,0.8975,pathogenic,-4.295,available,https://doi.org/10.1101/2022.10.22.513328 +T231H,NP_000537:p.Thr231His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.75118,1.1040863990783691,-0.13639,0.4990386603079283,0.307395,0.6251093301539641,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.93,E,-0.3967,0.1477,-22.239,-6.11656078059592,0.3757263853028462,Uncertain,0.9099,pathogenic,-4.036,available,https://doi.org/10.1101/2022.10.22.513328 +T231I,NP_000537:p.Thr231Ile,"hg19,17:g.7577589G>A, hg38,17:g.7674271G>A",,,0.942,"COSMIC,ClinVar,saturation_mutlist",458557,Uncertain significance,2,,,Tier II - Potential,1,P53 DNA-binding domain (PF00870),2.60.40.720,-1.35682,-0.438738465309143,-1.13844,-1.0236333156865862,-1.24763,-1.1902266578432932,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.93,E,-0.2571,0.1477,-6.9513,-4.06529226224259,0.026361241822399,Benign,0.629,pathogenic,-3.482,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T231K,NP_000537:p.Thr231Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.76054,1.3669309616088867,0.46395,0.7889469859084083,-0.148295,0.014203492954204144,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.93,E,-0.3245,0.1477,-8.9511,-4.41711862174608,0.0071473746229998,Benign,0.9047,pathogenic,-3.779,available,https://doi.org/10.1101/2022.10.22.513328 +T231L,NP_000537:p.Thr231Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.89894,0.2603716850280761,-0.58027,-0.7630607807214546,-1.239605,-1.3310003903607273,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.93,E,-0.387,0.1477,-22.239,-5.78473906010772,0.1310760415523605,Benign,0.438,ambiguous,-3.69,available,https://doi.org/10.1101/2022.10.22.513328 +T231M,NP_000537:p.Thr231Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.94512,0.4513583779335022,-0.37313,0.0058246967307434,-1.159125,-0.9696476516346283,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.93,E,-0.354,0.1477,-22.239,-6.2330233517437,0.739447417024613,Pathogenic,0.3261,benign,-4.094,available,https://doi.org/10.1101/2022.10.22.513328 +T231N,NP_000537:p.Thr231Asn,"hg19,17:g.7577589G>T, hg38,17:g.7674271G>T",,,0.885,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.26284,1.605972409248352,0.81599,0.7868747530815523,0.539415,0.5248573765407761,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,96.93,E,-0.3648,0.1477,-22.239,-4.86983639876597,0.4706144361447789,Uncertain,0.7626,pathogenic,-3.818,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T231P,NP_000537:p.Thr231Pro,"hg19,17:g.7577590T>G, hg38,17:g.7674272T>G",,,0.959,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.44653,1.8427811861038208,0.36054,2.4216006994158734,-0.04299499999999998,0.9875353497079367,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,96.93,E,-0.4006,0.1477,-7.9512,-5.90431671926836,0.2484307165040373,Benign,0.8364,pathogenic,-3.92,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T231Q,NP_000537:p.Thr231Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.18643,1.0451241731643677,-0.2585,0.6801324817904936,-0.22246500000000002,0.2468512408952468,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.93,E,-0.3743,0.1477,-22.239,-6.42307784301514,0.3247127276150378,Uncertain,0.8532,pathogenic,-3.897,available,https://doi.org/10.1101/2022.10.22.513328 +T231R,NP_000537:p.Thr231Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.35041,1.2554030418395996,0.62313,0.3191330808067411,0.13635999999999998,-0.01563845959662946,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.93,E,-0.3951,0.1477,-22.239,-5.0623118032494,0.2588560785715943,Benign,0.858,pathogenic,-3.946,available,https://doi.org/10.1101/2022.10.22.513328 +T231S,NP_000537:p.Thr231Ser,"hg19,17:g.7577589G>C, hg38,17:g.7674271G>C, hg38,17:g.7674272T>A",,,"0.916, 0.922","COSMIC,ClinVar,saturation_mutlist",921142,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.52475,0.9673935770988464,1.24456,1.276457439935799,0.8846550000000001,0.9006037199678996,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,neutral,,,DOWN,destabilizing,neutral,False,neutral,neutral,96.93,E,-0.2051,0.1477,-8.9511,-4.12712806788995,0.2161090983897186,Benign,0.5804,pathogenic,-3.694,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T231V,NP_000537:p.Thr231Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.91668,-0.3029308319091797,-1.12585,-0.7683608979375212,-1.021265,-0.8425204489687605,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.93,E,-0.3227,0.1477,-22.239,-5.18538203131054,0.0052048249500055,Benign,0.3308,benign,-3.58,available,https://doi.org/10.1101/2022.10.22.513328 +T231W,NP_000537:p.Thr231Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.16895,0.098334789276123,-1.0432,-0.3466016449383008,-0.6060749999999999,-0.25777582246915043,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.93,E,-0.4093,0.1477,-22.239,-6.78196048107463,0.8242178821937223,Pathogenic,0.9693,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328 +T231Y,NP_000537:p.Thr231Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15963,0.2169462442398071,-0.76327,0.0827960182761983,-0.46145,-0.03841699086190085,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.165,,,Uncertain,,Uncertain,,,Uncertain,30.4,,False,30.4,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.93,E,-0.4179,0.1477,-22.239,-6.78196048107463,0.8430965026229866,Pathogenic,0.9298,pathogenic,-4.377,available,https://doi.org/10.1101/2022.10.22.513328 +I232A,NP_000537:p.Ile232Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.72811,2.733074188232422,3.69422,2.681101868551602,3.7111650000000003,3.204605934275801,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.67,E,-0.3281,1.0667,-22.239,-5.13906058371721,0.6088076276725828,Uncertain,0.9749,pathogenic,-3.983,available,https://doi.org/10.1101/2022.10.22.513328 +I232C,NP_000537:p.Ile232Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.84648,1.6298952102661133,3.15204,2.7642467317774977,2.99926,2.805363365888749,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.67,E,-0.3081,1.0667,-22.239,-4.28662440160875,0.4348429979763812,Uncertain,0.977,pathogenic,-3.97,available,https://doi.org/10.1101/2022.10.22.513328 +I232D,NP_000537:p.Ile232Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.88736,3.900481939315796,3.4915,3.8404244831071934,3.6894299999999998,3.8638922415535966,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.67,E,-0.4522,1.0667,-22.239,-3.67836703647061,0.4617018685870929,Uncertain,0.9993,pathogenic,-4.392,available,https://doi.org/10.1101/2022.10.22.513328 +I232E,NP_000537:p.Ile232Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.33569,3.3846640586853027,3.74558,3.576340465445941,3.540635,3.4560152327229705,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.67,E,-0.4331,1.0667,-22.239,-3.73571401109809,0.0721747836705077,Benign,0.9969,pathogenic,-4.026,available,https://doi.org/10.1101/2022.10.22.513328 +I232F,NP_000537:p.Ile232Phe,"hg19,17:g.7577585_7577587delinsAAA, hg19,17:g.7577587T>A, hg19,17:g.7674269T>A, hg38,17:g.7674269T>A",,,0.840,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2827498,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.40592,1.3368638753890991,1.26327,0.8722736378294418,0.834595,0.6390968189147209,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.67,E,-0.2162,1.0667,-7.9512,-3.25419754051757,0.3577311121598588,Uncertain,0.7616,pathogenic,-3.848,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232G,NP_000537:p.Ile232Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.43018,3.79984712600708,5.98912,4.572820685510825,5.70965,5.0015003427554126,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.67,E,-0.4188,1.0667,-22.239,-5.84368071333109,0.5208613178197388,Uncertain,0.9972,pathogenic,-4.044,available,https://doi.org/10.1101/2022.10.22.513328 +I232H,NP_000537:p.Ile232His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.42471,2.5796568393707275,3.1551,2.135278467835048,2.789905,2.279994233917524,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.67,E,-0.4187,1.0667,-22.239,-4.04050323028216,0.3363015091277291,Uncertain,0.9943,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +I232K,NP_000537:p.Ile232Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.92842,2.9283664226531982,3.21088,3.3451508482647894,2.56965,2.6367854241323947,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.67,E,-0.4256,1.0667,-22.239,-5.64713189881151,0.7166118200678055,Pathogenic,0.9948,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328 +I232L,NP_000537:p.Ile232Leu,"hg19,17:g.7577587T>G, hg38,17:g.7674269T>G",,,0.688,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",482214,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30632,1.2107435464859009,0.79762,0.7497664141562562,0.55197,0.5280432070781281,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.67,E,-0.1404,1.0667,-7.9512,-1.93940326671129,0.0002225773735076,Benign,0.396,ambiguous,-3.354,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232M,NP_000537:p.Ile232Met,"hg19,17:g.7577585G>C, hg38,17:g.7674267G>C",,,0.776,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.25975,1.8465826511383057,1.71735,1.6421824656709938,0.9885499999999999,0.9509662328354969,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.67,E,-0.219,1.0667,-22.239,-3.21988801821096,0.0398478296372609,Benign,0.5496,ambiguous,-3.7,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232N,NP_000537:p.Ile232Asn,"hg19,17:g.7577585_7577586delinsAT, hg19,17:g.7577586A>T, hg19,17:g.7674268A>T, hg38,17:g.7674268A>T",,,0.916,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",850008,Pathogenic/Likely pathogenic,2,,,Tier II - Potential,0,P53 DNA-binding domain (PF00870),2.60.40.720,2.81966,3.52254056930542,2.83333,2.8394038583405568,2.826495,2.8295319291702783,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.67,E,-0.3653,1.0667,-22.239,-3.0625427012979,0.1480137911112391,Benign,0.9876,pathogenic,-3.981,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232P,NP_000537:p.Ile232Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.24352,3.631672382354736,4.47551,5.963893310365142,3.859515,4.603706655182571,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.67,E,-0.4722,1.0667,-22.239,-5.84368071333109,0.7277599087313509,Pathogenic,0.997,pathogenic,-4.457,available,https://doi.org/10.1101/2022.10.22.513328 +I232Q,NP_000537:p.Ile232Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.83145,3.088509559631348,2.99422,2.708083747795164,2.912835,2.7697668738975816,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.67,E,-0.3928,1.0667,-22.239,-4.40456442628339,0.700273728571571,Pathogenic,0.9948,pathogenic,-4.332,available,https://doi.org/10.1101/2022.10.22.513328 +I232R,NP_000537:p.Ile232Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.55126,2.988050937652588,3.31973,2.6432359691396456,2.435495,2.097247984569823,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.67,E,-0.4524,1.0667,-22.239,-5.5544944781831,0.6437415361620338,Uncertain,0.9907,pathogenic,-4.213,available,https://doi.org/10.1101/2022.10.22.513328 +I232S,NP_000537:p.Ile232Ser,"hg19,17:g.7577586A>C, hg19,17:g.7674268A>C, hg38,17:g.7674268A>C",,,0.935,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634756,Pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.46097,3.175227642059326,4.37687,3.4127626635355592,3.91892,3.4368663317677797,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.67,E,-0.3687,1.0667,-22.239,-5.13906058371721,0.203197629762446,Benign,0.9826,pathogenic,-4.052,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232T,NP_000537:p.Ile232Thr,"hg19,17:g.7577586A>G, hg19,17:g.7674268A>G, hg38,17:g.7674268A>G",,,0.920,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141224,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.07647,2.385633707046509,2.56837,2.1972272684387035,2.82242,2.636848634219352,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.67,E,-0.2177,1.0667,-8.9511,-3.44402482831382,0.0300620563381371,Benign,0.9462,pathogenic,-3.564,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232V,NP_000537:p.Ile232Val,"hg38,17:g.7674269T>C",,,0.419,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.2914,0.8357594013214111,0.8381,0.7249550253150185,1.06475,1.0081775126575092,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.67,E,-0.0665,1.0667,-1.2789,-0.453565725717669,5.056418389032498e-10,Benign,0.1023,benign,-2.91,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I232W,NP_000537:p.Ile232Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.53846,1.599605917930603,1.78367,1.3978396887500162,1.161065,0.9681498443750081,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.67,E,-0.378,1.0667,-22.239,-4.5773278072054,0.7876468785053908,Pathogenic,0.9921,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328 +I232Y,NP_000537:p.Ile232Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42042,1.3543787002563477,0.8432,1.3830767019341277,1.13181,1.4017483509670638,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.267,,,,,,,,,10.8,,False,10.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.67,E,-0.3869,1.0667,-22.239,-3.79092410364773,0.0197158850767008,Benign,0.9737,pathogenic,-3.832,available,https://doi.org/10.1101/2022.10.22.513328 +H233A,NP_000537:p.His233Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.80746,0.9053711891174316,-0.03367,1.14053373699977,0.386895,0.973996868499885,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.32,E,-0.2276,0.7543,-22.239,-4.06438622112277,0.1891454750961927,Benign,0.9624,pathogenic,-3.595,available,https://doi.org/10.1101/2022.10.22.513328 +H233C,NP_000537:p.His233Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.43072,0.0688719749450683,1.01293,1.5760114125747409,0.721825,1.0033657062873704,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.32,E,-0.2822,0.7543,-22.239,-4.83982206306066,0.074721208818033,Benign,0.5793,pathogenic,-3.595,available,https://doi.org/10.1101/2022.10.22.513328 +H233D,NP_000537:p.His233Asp,"hg19,17:g.7577584G>C, hg38,17:g.7674266G>C",,,0.876,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.17747,1.5204453468322754,0.5915,1.2790591923541328,0.884485,1.2282645961770664,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.32,E,-0.2749,0.7543,-22.239,-5.26877135992122,0.3535546661837397,Uncertain,0.9787,pathogenic,-3.888,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H233E,NP_000537:p.His233Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.44696,1.0720826387405396,0.7898,1.075973048377158,0.6183799999999999,0.761466524188579,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.32,E,-0.2864,0.7543,-22.239,-5.30549539841015,0.5129470580525862,Uncertain,0.9877,pathogenic,-3.888,available,https://doi.org/10.1101/2022.10.22.513328 +H233F,NP_000537:p.His233Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.23496,0.2272826433181762,-0.95442,-0.8226883074766173,-1.09469,-1.0288241537383087,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.32,E,-0.1815,0.7543,-8.9511,-2.73899604344791,0.0001861872444207,Benign,0.755,pathogenic,-3.274,available,https://doi.org/10.1101/2022.10.22.513328 +H233G,NP_000537:p.His233Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.04508,1.6238186359405518,1.74286,2.390239106999853,1.89397,2.2176595534999266,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.32,E,-0.3102,0.7543,-22.239,-5.67448993785425,0.299062538164983,Benign,0.9764,pathogenic,-3.829,available,https://doi.org/10.1101/2022.10.22.513328 +H233I,NP_000537:p.His233Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.00032,0.0836420059204101,0.44728,0.3092420153328451,-0.27652000000000004,-0.3455389923335775,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.32,E,-0.3139,0.7543,-22.239,-2.95793505870609,0.0274013108889186,Benign,0.9485,pathogenic,-3.438,available,https://doi.org/10.1101/2022.10.22.513328 +H233K,NP_000537:p.His233Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.5133,0.6272045969963074,0.04082,1.0477096235505048,-0.23623999999999998,0.2672048117752524,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.32,E,-0.2706,0.7543,-22.239,-6.05142462374371,0.7288448461838565,Pathogenic,0.9856,pathogenic,-3.763,available,https://doi.org/10.1101/2022.10.22.513328 +H233L,NP_000537:p.His233Leu,"hg38,17:g.7674265T>A",,,0.579,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.21061,0.2041878700256347,-1.04932,-0.4258992746742546,-1.1299649999999999,-0.8182546373371273,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.32,E,-0.1657,0.7543,-0.3366,-1.13391902925994,1.45101055753223e-07,Benign,0.3678,ambiguous,-2.775,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H233M,NP_000537:p.His233Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.86823,0.4643500447273254,-0.24422,0.1736198537902733,-0.556225,-0.3473050731048633,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.32,E,-0.2276,0.7543,-22.239,-2.68795692342236,0.0040939481984036,Benign,0.9371,pathogenic,-3.344,available,https://doi.org/10.1101/2022.10.22.513328 +H233N,NP_000537:p.His233Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.40297,0.6016102433204651,-0.29252,0.793688244955969,0.055224999999999996,0.5983291224779845,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.32,E,-0.2344,0.7543,-22.239,-5.29135763745226,0.5070253047374477,Uncertain,0.7507,pathogenic,-3.636,available,https://doi.org/10.1101/2022.10.22.513328 +H233P,NP_000537:p.His233Pro,"hg38,17:g.7674265T>G",,,0.844,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.30861,1.5860955715179443,-0.83027,2.535766331454983,-0.56944,1.1135781657274917,Neutral,Uncertain,Uncertain,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.32,E,-0.3909,0.7543,-22.239,-6.70333838902764,0.4298440117530282,Uncertain,0.8782,pathogenic,-3.674,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H233Q,NP_000537:p.His233Gln,"hg38,17:g.7674264G>C, hg38,17:g.7674264G>T",,,0.669,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.34141,0.7178233861923218,0.14558,0.8193412441042192,0.243495,0.5803756220521096,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.32,E,-0.1959,0.7543,-22.239,-5.6517055286347,0.8071482882056782,Pathogenic,0.9481,pathogenic,-3.682,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H233R,NP_000537:p.His233Arg,"hg19,17:g.7577583T>C, hg38,17:g.7674265T>C",,,0.717,"COSMIC,ClinVar,saturation_mutlist",246388,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.58576,0.5727308988571167,-0.14354,0.4282968247212282,-0.36465,-0.07873158763938587,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.32,E,-0.264,0.7543,-22.239,-5.39308725596142,0.1607460806607719,Benign,0.9072,pathogenic,-3.534,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +H233S,NP_000537:p.His233Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.70235,0.7431024312973022,0.78265,1.5997032622184093,1.2425,1.6510266311092048,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.32,E,-0.2336,0.7543,-22.239,-4.90369467746375,0.1719755398424981,Benign,0.9307,pathogenic,-3.485,available,https://doi.org/10.1101/2022.10.22.513328 +H233T,NP_000537:p.His233Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.95053,0.5054591298103333,0.59184,1.1742189314085254,0.771185,1.0623744657042626,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.32,E,-0.2784,0.7543,-22.239,-4.96568135487633,0.5821690695464069,Uncertain,0.9712,pathogenic,-3.6,available,https://doi.org/10.1101/2022.10.22.513328 +H233V,NP_000537:p.His233Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.05454,0.141349196434021,0.85646,0.4063455507639901,0.4555,0.23044277538199504,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.32,E,-0.2703,0.7543,-22.239,-3.74262829021983,0.6186441012884615,Uncertain,0.9371,pathogenic,-3.626,available,https://doi.org/10.1101/2022.10.22.513328 +H233W,NP_000537:p.His233Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.41096,0.0820643901824951,-0.53776,-0.9544703092626916,-0.47436,-0.6827151546313458,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.32,E,-0.2655,0.7543,-22.239,-4.51441976804299,0.789039925514924,Pathogenic,0.8275,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328 +H233Y,NP_000537:p.His233Tyr,"hg19,17:g.7577584G>A, hg38,17:g.7674266G>A",,,0.690,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.05244,-0.125399112701416,-0.86735,-0.5865810598508125,-0.9598949999999999,-0.8195105299254063,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.278,,,Uncertain,,Uncertain,,,Uncertain,49.4,,False,49.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.32,E,-0.1995,0.7543,-22.239,-1.78984626143471,0.040894694442997,Benign,0.4592,ambiguous,-3.673,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234A,NP_000537:p.Tyr234Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.48782,1.3066881895065308,4.30544,4.105244776775823,4.39663,4.296532388387911,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.3946,0.6244,-22.2332,-5.30051108287355,0.8131356259477241,Pathogenic,0.9901,pathogenic,-4.416,available,https://doi.org/10.1101/2022.10.22.513328 +Y234C,NP_000537:p.Tyr234Cys,"hg19,17:g.7577580T>C, hg19,17:g.7674262T>C, hg38,17:g.7674262T>C",,3.9764593606e-06,0.945,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127820,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.82286,0.4038208723068237,4.16905,4.320663441580765,3.9959550000000004,4.0717617207903825,Destabilizing,Destabilizing,Neutral,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.3652,0.6244,-22.2332,-6.44662477801322,0.8434517422407979,Pathogenic,0.8,pathogenic,-4.003,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234D,NP_000537:p.Tyr234Asp,"hg19,17:g.7577581A>C, hg19,17:g.7674263A>C, hg38,17:g.7674263A>C",,,0.876,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",219759,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.75745,2.308468580245972,4.9085,4.860266026925788,5.332975,5.308858013462894,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.4088,0.6244,-22.2332,-6.80960627818916,0.7285842565188764,Pathogenic,0.9975,pathogenic,-4.619,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234E,NP_000537:p.Tyr234Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.26604,1.922261357307434,4.27007,4.516879755765319,3.7680549999999995,3.8914598778826592,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.4375,0.6244,-22.2332,-6.80960627818916,0.7890939240712694,Pathogenic,0.9991,pathogenic,-4.631,available,https://doi.org/10.1101/2022.10.22.513328 +Y234F,NP_000537:p.Tyr234Phe,"hg38,17:g.7674262T>A",,,0.686,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.58076,-0.6942193508148193,-0.15544,0.357075834388697,-0.36810000000000004,-0.11184208280565153,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.96,E,-0.15,0.6244,-6.1381,-1.56308951962019,8.983210709395668e-06,Benign,0.0991,benign,-3.104,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234G,NP_000537:p.Tyr234Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.59889,1.790727138519287,6.26361,5.713128461522917,5.93125,5.656009230761459,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.4651,0.6244,-22.2332,-6.80960627818916,0.7217997233964804,Pathogenic,0.9754,pathogenic,-4.374,available,https://doi.org/10.1101/2022.10.22.513328 +Y234H,NP_000537:p.Tyr234His,"hg19,17:g.7577581A>G, hg19,17:g.7674263A>G, hg38,17:g.7674263A>G",,,0.890,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376691,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.02118,1.4474551677703855,2.77211,2.4665585581773373,2.8966450000000004,2.7438692790886687,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.3023,0.6244,-22.2332,-4.09950607784027,0.764616884486288,Pathogenic,0.9891,pathogenic,-4.166,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234I,NP_000537:p.Tyr234Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.64861,-0.2427287101745605,2.61735,2.546546107157558,2.13298,2.097578053578779,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.3388,0.6244,-8.9453,-3.29952705774347,0.0375445911581829,Benign,0.8428,pathogenic,-3.946,available,https://doi.org/10.1101/2022.10.22.513328 +Y234K,NP_000537:p.Tyr234Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.2155,1.685258150100708,4.95204,4.764592998260878,4.5837699999999995,4.490046499130439,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.4628,0.6244,-22.2332,-6.80960627818916,0.7901960575415723,Pathogenic,0.9989,pathogenic,-4.634,available,https://doi.org/10.1101/2022.10.22.513328 +Y234L,NP_000537:p.Tyr234Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.56945,-0.5877463817596436,1.53673,1.842759753979784,1.05309,1.206104876989892,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.2865,0.6244,-3.1906,-2.74410102072675,3.631787118428928e-06,Benign,0.3996,ambiguous,-3.504,available,https://doi.org/10.1101/2022.10.22.513328 +Y234M,NP_000537:p.Tyr234Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.93946,-0.1101464033126831,1.67245,2.289485534701049,1.305955,1.6144727673505246,Neutral,Uncertain,Neutral,Neutral,Neutral,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.3358,0.6244,-22.2332,-4.98663984119722,0.7771411342636707,Pathogenic,0.8706,pathogenic,-4.244,available,https://doi.org/10.1101/2022.10.22.513328 +Y234N,NP_000537:p.Tyr234Asn,"hg19,17:g.7577581A>T, hg19,17:g.7674263A>T, hg38,17:g.7674263A>T, hg38,17:g.7674263_7674264delinsTA",,,0.941,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376692,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.39002,1.8776700496673584,4.0881,3.82935510718748,3.73906,3.60968755359374,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.3878,0.6244,-22.2332,-6.80960627818916,0.7878926811120062,Pathogenic,0.9909,pathogenic,-4.415,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234P,NP_000537:p.Tyr234Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.66534,1.921324253082276,7.96463,7.228051451260264,7.314985,6.946695725630132,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.5188,0.6244,-22.2332,-6.80960627818916,0.8441278531417278,Pathogenic,0.998,pathogenic,-4.697,available,https://doi.org/10.1101/2022.10.22.513328 +Y234Q,NP_000537:p.Tyr234Gln,"hg19,17:g.7577579_7577581delinsCTG, hg38,17:g.7674261_7674263delinsCTG",,,,"ClinVar,saturation_mutlist",2751786,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.08214,1.5430573225021362,3.39184,3.844593772022955,3.23699,3.4633668860114772,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.4123,0.6244,-22.2332,-6.80960627818916,0.8267703896137975,Pathogenic,0.9986,pathogenic,-4.474,available,https://doi.org/10.1101/2022.10.22.513328 +Y234R,NP_000537:p.Tyr234Arg,"hg38,17:g.7674262_7674263delinsCG",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.30556,1.7561709880828855,3.35408,3.838503321477877,3.82982,4.072031660738938,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.4581,0.6244,-22.2332,-6.80960627818916,0.4442572620894961,Uncertain,0.997,pathogenic,-4.295,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234S,NP_000537:p.Tyr234Ser,"hg19,17:g.7577580T>G, hg19,17:g.7674262T>G, hg38,17:g.7674262T>G",,,0.936,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376690,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.28072,1.686648964881897,4.97279,4.891947242576787,5.126754999999999,5.086333621288393,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.3993,0.6244,-22.2332,-6.44662477801322,0.8155826251834095,Pathogenic,0.9852,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y234T,NP_000537:p.Tyr234Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.22424,1.2416936159133911,3.75884,4.188413712183359,3.99154,4.20632685609168,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.4179,0.6244,-22.2332,-6.44662477801322,0.4990018039161688,Uncertain,0.9894,pathogenic,-4.292,available,https://doi.org/10.1101/2022.10.22.513328 +Y234V,NP_000537:p.Tyr234Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.16619,0.1833466291427612,3.41088,3.1469975886096067,3.288535,3.1565937943048032,Destabilizing,Destabilizing,Neutral,Destabilizing,Destabilizing,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,DOWN,mixed_effects,neutral,False,neutral,neutral,97.96,E,-0.3962,0.6244,-22.2332,-4.98663984119722,0.7904365545728758,Pathogenic,0.8024,pathogenic,-4.04,available,https://doi.org/10.1101/2022.10.22.513328 +Y234W,NP_000537:p.Tyr234Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.63936,0.3081936836242676,-0.47347,1.362940489877028,0.5829449999999999,1.501150244938514,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.245,,,,,,,,,1.1,,False,1.1,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.96,E,-0.3121,0.6244,-22.2332,-4.09950607784027,0.8186385897816553,Pathogenic,0.8383,pathogenic,-4.294,available,https://doi.org/10.1101/2022.10.22.513328 +N235A,NP_000537:p.Asn235Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.77534,0.1442162096500396,-0.84524,0.4187341275990935,-0.03494999999999998,0.5970370637995468,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.97,E,-0.2785,0.5476,-22.239,-3.89285589000458,0.3923519926420194,Uncertain,0.6884,pathogenic,-3.843,available,https://doi.org/10.1101/2022.10.22.513328 +N235C,NP_000537:p.Asn235Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48828,-0.4897386431694031,-0.23503,0.7539877917798656,0.126625,0.6211338958899328,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.97,E,-0.3284,0.5476,-22.239,-3.9275215297451,0.7251642937963347,Pathogenic,0.4606,ambiguous,-4.094,available,https://doi.org/10.1101/2022.10.22.513328 +N235D,NP_000537:p.Asn235Asp,"hg19,17:g.7577578T>C, hg38,17:g.7674260T>C",,,0.912,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",919580,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.81263,0.4809499382972717,1.74694,1.3906255889428734,2.779785,2.6016277944714368,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.97,E,-0.2817,0.5476,-22.239,-4.00222966243389,0.8573187375776279,Pathogenic,0.8126,pathogenic,-4.25,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235E,NP_000537:p.Asn235Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.15557,-0.1602843403816223,0.46156,0.851562157321696,1.308565,1.503566078660848,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.97,E,-0.3088,0.5476,-22.239,-3.51635481758845,0.3730297505020503,Uncertain,0.959,pathogenic,-4.027,available,https://doi.org/10.1101/2022.10.22.513328 +N235F,NP_000537:p.Asn235Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.33574,0.028586983680725,2.70034,-0.391822457632649,3.51804,1.9719587711836757,Uncertain,Uncertain,Neutral,Destabilizing,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.97,E,-0.3357,0.5476,-22.239,-5.71782841479094,0.5936106531669454,Uncertain,0.9717,pathogenic,-4.19,available,https://doi.org/10.1101/2022.10.22.513328 +N235G,NP_000537:p.Asn235Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.11062,0.7056841850280762,1.27483,2.0024004053639173,1.6927249999999998,2.0565102026819586,Uncertain,Uncertain,Neutral,Neutral,Uncertain,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.97,E,-0.3093,0.5476,-22.239,-6.63170971104971,0.6933695741011554,Pathogenic,0.7788,pathogenic,-4.206,available,https://doi.org/10.1101/2022.10.22.513328 +N235H,NP_000537:p.Asn235His,"hg38,17:g.7674260T>G",,,0.902,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.23125,-0.042055606842041,0.98367,0.1103937233379792,1.60746,1.1708218616689896,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.97,E,-0.2835,0.5476,-22.239,-4.59891063784102,0.6609007583480746,Uncertain,0.3915,ambiguous,-3.822,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235I,NP_000537:p.Asn235Ile,"hg19,17:g.7577577T>A, hg38,17:g.7674259T>A",,3.9763961127e-06,0.886,"COSMIC,ClinVar,saturation_mutlist",3673072,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.31656,-0.4909980893135071,-0.63061,-0.5968959119703804,-0.157025,-0.1401679559851902,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.97,E,-0.3288,0.5476,-22.239,-5.06640171466846,0.4750299755105782,Uncertain,0.8491,pathogenic,-4.06,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235K,NP_000537:p.Asn235Lys,"hg19,17:g.7577576G>C",,,0.565,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.33609,-0.2874371409416199,-0.63741,0.4263123646674421,-0.48675,0.04511118233372105,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.97,E,-0.1977,0.5476,-5.7813,-1.52572489034109,0.0027619354383635,Benign,0.8166,pathogenic,-3.605,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235L,NP_000537:p.Asn235Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.86886,-0.2857750654220581,-1.62721,-0.8981292167899557,-1.248035,-0.8834946083949778,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.97,E,-0.3352,0.5476,-22.239,-5.62147723552449,0.7907897634769809,Pathogenic,0.7526,pathogenic,-4.049,available,https://doi.org/10.1101/2022.10.22.513328 +N235M,NP_000537:p.Asn235Met,"hg38,17:g.7674258_7674259delinsCA",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.67399,-0.4252689480781555,-1.34966,-0.276517825289822,-1.011825,-0.475253912644911,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.97,E,-0.2894,0.5476,-22.239,-5.96096504736547,0.7235454533082708,Pathogenic,0.8714,pathogenic,-4.15,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235P,NP_000537:p.Asn235Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.21874,1.8783974647521973,3.08367,4.899661118738503,3.651205,4.559200559369252,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.97,E,-0.4441,0.5476,-22.239,-6.63170971104971,0.8369666341178299,Pathogenic,0.9912,pathogenic,-4.493,available,https://doi.org/10.1101/2022.10.22.513328 +N235Q,NP_000537:p.Asn235Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.27943,-0.6909491419792175,-0.97449,0.3337857975510205,-0.34753,0.30660789877551026,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.97,E,-0.2725,0.5476,-22.239,-2.96507093069345,0.1001261408992443,Benign,0.7732,pathogenic,-3.708,available,https://doi.org/10.1101/2022.10.22.513328 +N235R,NP_000537:p.Asn235Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.60117,-0.3398864269256592,-1.32211,-0.1932948186133659,-0.9616399999999999,-0.3972324093066829,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.97,E,-0.2461,0.5476,-8.9511,-3.30319615207498,0.0187244287318889,Benign,0.7411,pathogenic,-3.716,available,https://doi.org/10.1101/2022.10.22.513328 +N235S,NP_000537:p.Asn235Ser,"hg19,17:g.7577577T>C, hg38,17:g.7674259T>C",0.0003198362438432,0.0001789378250704,0.593,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127821,Benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.51453,-0.5406624674797058,0.12143,1.0743763401236013,0.8179799999999999,1.2944531700618005,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.97,E,-0.1536,0.5476,-3.6659,-2.64118094815742,9.891768033379236e-06,Benign,0.1402,benign,-3.258,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235T,NP_000537:p.Asn235Thr,"hg19,17:g.7577577T>G, hg38,17:g.7674259T>G",,,0.872,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.04293,-1.2584879398345947,-0.48299,0.367827982685347,0.27996999999999994,0.7053789913426735,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.97,E,-0.298,0.5476,-22.239,-3.17005902451428,0.2394262916077165,Benign,0.5234,ambiguous,-3.682,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N235V,NP_000537:p.Asn235Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2683,-0.6721181273460388,-2.37177,-0.3597992435364616,-1.320035,-0.3140496217682308,Uncertain,Neutral,Neutral,Neutral,Neutral,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.97,E,-0.3221,0.5476,-22.239,-5.63693704446803,0.6741832128608591,Uncertain,0.7546,pathogenic,-4.002,available,https://doi.org/10.1101/2022.10.22.513328 +N235W,NP_000537:p.Asn235Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.77582,-0.003525972366333,0.2017,-0.6276359621799832,2.48876,2.0740920189100085,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.97,E,-0.3408,0.5476,-22.239,-5.71782841479094,0.8542773095716907,Pathogenic,0.9843,pathogenic,-4.598,available,https://doi.org/10.1101/2022.10.22.513328 +N235Y,NP_000537:p.Asn235Tyr,"hg19,17:g.7577578T>A, hg38,17:g.7674260T>A",,,0.932,"COSMIC,ClinVar,saturation_mutlist",188206,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.91751,0.115621417760849,3.09966,-0.2632872621002596,4.008585,2.32711136894987,Destabilizing,Uncertain,Neutral,Destabilizing,Uncertain,True,0.226,,,,,,,,,14.1,,False,14.1,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.97,E,-0.3192,0.5476,-22.239,-5.15056092513449,0.6774580667997819,Uncertain,0.7572,pathogenic,-4.091,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236A,NP_000537:p.Tyr236Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.34008,2.746455430984497,5.04728,4.85064827356823,5.6936800000000005,5.595364136784115,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.0,,,,,0.0,,,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.3815,0.7671,-22.2419,-6.69585764268672,0.6727282662254873,Uncertain,0.9966,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328 +Y236C,NP_000537:p.Tyr236Cys,"hg19,17:g.7577574T>C, hg19,17:g.7674256T>C, hg38,17:g.7674256T>C",,,0.811,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376693,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.33301,2.081073760986328,4.65136,5.036121265358198,4.992185,5.184565632679099,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.0,0.0709,Neutral,,,0.0,0.07997,Neutral,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.3521,0.7671,-22.2419,-6.69585764268672,0.4349196484452341,Uncertain,0.9599,pathogenic,-3.774,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236D,NP_000537:p.Tyr236Asp,"hg19,17:g.7577575A>C, hg19,17:g.7674257A>C, hg38,17:g.7674257A>C",,,0.845,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142183,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.34272,3.232537031173706,5.4068,5.930738084971694,5.87476,6.136729042485847,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.1121,-0.06182,Neutral,,,0.00685,-0.08582,Neutral,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.3957,0.7671,-22.2419,-6.69585764268672,0.1483324630442684,Benign,0.9936,pathogenic,-4.28,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236E,NP_000537:p.Tyr236Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.12333,2.954785108566284,5.04966,5.488425883652994,5.586495,5.8058779418264965,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.08684,,,,,0.00287,,,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.4244,0.7671,-22.2419,-6.69585764268672,0.6747380281501533,Uncertain,0.9993,pathogenic,-4.439,available,https://doi.org/10.1101/2022.10.22.513328 +Y236F,NP_000537:p.Tyr236Phe,"hg19,17:g.7577574T>A, hg38,17:g.7674256T>A",,,0.468,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.73863,0.5867066383361816,0.43741,1.0216106289903029,0.58802,0.8801203144951515,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.25,0.0,0.22169,Neutral,,,0.0,-0.04874,Neutral,0.0,,False,0.0,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.83,E,-0.1074,0.7671,-0.3655,-0.344773940656653,7.666419774018076e-13,Benign,0.0654,benign,-2.694,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236G,NP_000537:p.Tyr236Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.70845,2.8945908546447754,7.72449,6.643870719766478,7.71647,7.176160359883239,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.0,,,,,0.0,,,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.452,0.7671,-22.2419,-6.69585764268672,0.6086398998221857,Uncertain,0.9931,pathogenic,-4.362,available,https://doi.org/10.1101/2022.10.22.513328 +Y236H,NP_000537:p.Tyr236His,"hg19,17:g.7577575A>G, hg19,17:g.7674257A>G, hg38,17:g.7674257A>G",,,0.772,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",216469,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.32553,2.0924782752990723,3.45646,3.12448438497262,3.8909949999999998,3.7250071924863097,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.0,-0.12037,Neutral,,,0.0,0.03454,Neutral,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.2892,0.7671,-22.2419,-4.01811152617371,0.5281329031450582,Uncertain,0.982,pathogenic,-4.041,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236I,NP_000537:p.Tyr236Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.39365,2.009263038635254,3.15782,3.1235187921207035,3.275735,3.2585843960603516,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.00018,,,,,0.00196,,,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.3935,0.7671,-22.2419,-6.24692007678165,0.6460567811563991,Uncertain,0.9786,pathogenic,-3.805,available,https://doi.org/10.1101/2022.10.22.513328 +Y236K,NP_000537:p.Tyr236Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.22014,2.84649658203125,5.20238,6.224097037612744,4.711259999999999,5.222118518806372,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,-0.00882,,,,,6e-05,,,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.4497,0.7671,-22.2419,-6.69585764268672,0.5983956495817317,Uncertain,0.9993,pathogenic,-4.474,available,https://doi.org/10.1101/2022.10.22.513328 +Y236L,NP_000537:p.Tyr236Leu,"hg38,17:g.7674255_7674256delinsTA",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.52588,2.065136432647705,2.63946,2.329162270581008,2.5826700000000002,2.4275211352905037,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.25,0.0,-0.0337,Neutral,,,0.0,0.08314,Neutral,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.3706,0.7671,-22.2419,-4.44282781099961,0.0199162357938249,Benign,0.9639,pathogenic,-3.47,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236M,NP_000537:p.Tyr236Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.74847,2.2177555561065674,3.0017,2.639658942058177,2.375085,2.1940644710290886,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.25,0.0,,,,,0.0,,,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.3227,0.7671,-22.2419,-6.24692007678165,0.6627166621305067,Uncertain,0.986,pathogenic,-4.016,available,https://doi.org/10.1101/2022.10.22.513328 +Y236N,NP_000537:p.Tyr236Asn,"hg19,17:g.7577575A>T, hg19,17:g.7674257A>T, hg38,17:g.7674257A>T",,,0.837,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376694,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.40286,2.899235248565674,4.5034,4.59017789046325,4.95313,4.996518945231625,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.0,0.01325,Neutral,,,0.0,0.02432,Neutral,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.3747,0.7671,-22.2419,-6.69585764268672,0.7727196034305899,Pathogenic,0.9869,pathogenic,-4.263,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236P,NP_000537:p.Tyr236Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.00627,2.697547197341919,6.27483,7.873350391842024,5.640549999999999,6.439810195921012,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.0,,,,,0.0,,,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.5057,0.7671,-22.2419,-6.69585764268672,0.6114516452143864,Uncertain,0.9986,pathogenic,-4.382,available,https://doi.org/10.1101/2022.10.22.513328 +Y236Q,NP_000537:p.Tyr236Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.35328,2.89369797706604,3.99388,4.506083976505826,4.673579999999999,4.929681988252913,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.0,,,,,0.0,,,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.3992,0.7671,-22.2419,-6.69585764268672,0.6837838608605176,Pathogenic,0.9991,pathogenic,-4.351,available,https://doi.org/10.1101/2022.10.22.513328 +Y236R,NP_000537:p.Tyr236Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.31123,2.667081117630005,3.51735,5.070864523647997,4.41429,5.191047261823998,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,-0.02384,,,,,-0.00072,,,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.445,0.7671,-22.2419,-6.69585764268672,0.7229686200231711,Pathogenic,0.9982,pathogenic,-4.39,available,https://doi.org/10.1101/2022.10.22.513328 +Y236S,NP_000537:p.Tyr236Ser,"hg19,17:g.7577573_7577574delinsAG, hg19,17:g.7577574T>G, hg19,17:g.7674256T>G, hg38,17:g.7674255_7674256delinsAG, hg38,17:g.7674256T>G",,,0.780,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182966,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,7.06097,2.9380156993865967,5.12381,5.972549082254838,6.09239,6.516759541127419,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.0,-0.01215,Neutral,,,0.0,0.00343,Neutral,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.3862,0.7671,-22.2419,-6.69585764268672,0.6671190041671116,Uncertain,0.9891,pathogenic,-4.063,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +Y236T,NP_000537:p.Tyr236Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.13777,2.712911367416382,5.45816,4.757636493039652,5.297965,4.947703246519826,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.0,,,,,0.0,,,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.4048,0.7671,-22.2419,-6.69585764268672,0.6605045967912799,Uncertain,0.9963,pathogenic,-4.331,available,https://doi.org/10.1101/2022.10.22.513328 +Y236V,NP_000537:p.Tyr236Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.46307,2.163480043411255,3.80102,3.538021188102912,4.132045,4.000545594051456,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.25,0.00426,,,,,0.0,,,0.0,,False,0.0,,uncertain,,,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,E,-0.3831,0.7671,-22.2419,-6.24692007678165,0.318476182684569,Benign,0.9677,pathogenic,-3.94,available,https://doi.org/10.1101/2022.10.22.513328 +Y236W,NP_000537:p.Tyr236Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.98483,0.5453879833221436,1.26905,2.06700828295126,1.12694,1.5259191414756301,Neutral,Uncertain,Neutral,Neutral,Neutral,True,0.25,0.0,,,,,0.0,,,0.0,,False,0.0,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,97.83,E,-0.299,0.7671,-22.2419,-4.01811152617371,0.7269624582484571,Pathogenic,0.8651,pathogenic,-4.034,available,https://doi.org/10.1101/2022.10.22.513328 +M237A,NP_000537:p.Met237Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.37092,1.5273106098175049,1.24422,1.7453581933091873,1.3075700000000001,1.5581390966545936,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.221,0.03716,,,,,0.00544,,,10.5,,False,10.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.66,-,-0.3979,0.042,-22.2419,-6.07174334805245,0.639768245115285,Uncertain,0.9724,pathogenic,-3.974,available,https://doi.org/10.1101/2022.10.22.513328 +M237C,NP_000537:p.Met237Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.78773,0.6373836994171143,1.36565,2.1139194889725275,1.5766900000000001,1.9508247444862636,Neutral,Uncertain,Neutral,Neutral,Neutral,True,0.221,0.03258,,,,,-0.00301,,,10.5,,False,10.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.66,-,-0.4034,0.042,-22.2419,-6.66034877067227,0.6943543867819147,Pathogenic,0.9643,pathogenic,-4.306,available,https://doi.org/10.1101/2022.10.22.513328 +M237D,NP_000537:p.Met237Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.55413,1.261417031288147,2.06803,2.064010668883863,1.81108,1.8090703344419317,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.221,0.3223,,,,,0.16366,,,10.5,,False,10.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.66,-,-0.5093,0.042,-22.2419,-8.03111563380106,0.8595507782668348,Pathogenic,0.9994,pathogenic,-4.813,available,https://doi.org/10.1101/2022.10.22.513328 +M237E,NP_000537:p.Met237Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.27814,0.9688599705696106,1.77211,1.7401191593411875,2.025125,2.009129579670594,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,True,0.221,0.09504,,,,,0.1393,,,10.5,,False,10.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.66,-,-0.4995,0.042,-22.2419,-8.03111563380106,0.868001950514842,Pathogenic,0.9938,pathogenic,-4.658,available,https://doi.org/10.1101/2022.10.22.513328 +M237F,NP_000537:p.Met237Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.813,1.1988481283187866,-0.51803,0.1298057676484132,2.6474849999999996,2.9714028838242066,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.221,0.00028,,,,,0.01674,,,10.5,,False,10.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.66,-,-0.4029,0.042,-22.2419,-6.71087496124933,0.6017076461000541,Uncertain,0.9152,pathogenic,-4.217,available,https://doi.org/10.1101/2022.10.22.513328 +M237G,NP_000537:p.Met237Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.12243,1.7744975090026855,2.57177,3.181069809179056,2.3471,2.6517499045895283,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.221,0.0397,,,,,-0.00066,,,10.5,,False,10.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.66,-,-0.4787,0.042,-22.2419,-7.37459769635706,0.4173001864604709,Uncertain,0.9862,pathogenic,-4.302,available,https://doi.org/10.1101/2022.10.22.513328 +M237H,NP_000537:p.Met237His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.65424,1.259530544281006,0.28878,1.141245395794798,2.47151,2.8977426978973986,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.221,-0.01962,,,,,0.04679,,,10.5,,False,10.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.66,-,-0.4561,0.042,-22.2419,-7.06518272089547,0.804841478903289,Pathogenic,0.988,pathogenic,-4.4,available,https://doi.org/10.1101/2022.10.22.513328 +M237I,NP_000537:p.Met237Ile,"hg19,17:g.7577570C>A, hg19,17:g.7577570C>G, hg19,17:g.7577570C>T, hg19,17:g.7674252C>A, hg19,17:g.7674252C>G, hg19,17:g.7674252C>T, hg38,17:g.7674252C>A, hg38,17:g.7674252C>G, hg38,17:g.7674252C>T",,3.9763961127e-06,0.923,"cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","1757269, 634770, 142714","Pathogenic/Likely pathogenic, Pathogenic/Likely pathogenic, Pathogenic","2, 2, 3",Oncogenic,1,"Tier I - Strong, Tier II - Potential","1, 1",P53 DNA-binding domain (PF00870),2.60.40.720,1.23103,1.6822738647460938,1.71803,0.033195342574383,1.4745300000000001,0.6321126712871915,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.221,-0.00058,-0.11851,Neutral,,,-0.00407,-0.01821,Neutral,10.5,,False,10.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.66,-,-0.2473,0.042,-8.9541,-4.13950426525933,0.6999422663171178,Pathogenic,0.9957,pathogenic,-3.982,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M237K,NP_000537:p.Met237Lys,"hg19,17:g.7577571A>T, hg19,17:g.7674253A>T, hg38,17:g.7674253A>T",,0.0,0.957,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376636,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.71393,2.505899906158448,1.49388,1.820829659335104,1.6039050000000001,1.767379829667552,Neutral,Neutral,Destabilizing,Neutral,Neutral,True,0.221,-0.13258,0.04051,Neutral,,,-0.09667,0.14549,Neutral,10.5,,False,10.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.66,-,-0.4604,0.042,-22.2419,-5.85174250580103,0.3879716862452536,Uncertain,0.9612,pathogenic,-4.087,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M237L,NP_000537:p.Met237Leu,"hg19,17:g.7577572T>A, hg19,17:g.7577572T>G, hg19,17:g.7674254T>A, hg38,17:g.7674254T>A, hg38,17:g.7674254T>G",,,0.941,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2774649, 1757126","Uncertain significance, Uncertain significance","1, 1",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.26039,0.333264946937561,0.07347,-0.401445809538104,-0.09346000000000002,-0.33091790476905203,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.221,0.0024,0.0371,Neutral,,,-0.00269,0.09095,Neutral,10.5,,False,10.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.66,-,-0.2821,0.042,-22.2419,-3.47470546913856,0.47721334846938,Uncertain,0.8667,pathogenic,-3.779,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M237N,NP_000537:p.Met237Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.23635,1.3892865180969238,1.01837,1.5614539740539686,0.62736,0.8989019870269843,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.221,-0.0094,,,,,-0.00206,,,10.5,,False,10.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.66,-,-0.4509,0.042,-22.2419,-8.03111563380106,0.8258743090259,Pathogenic,0.9905,pathogenic,-4.532,available,https://doi.org/10.1101/2022.10.22.513328 +M237P,NP_000537:p.Met237Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.90321,3.376983165740967,2.44422,5.209438809851982,3.173715,4.5563244049259914,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.221,0.03184,,,,,-0.00114,,,10.5,,False,10.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.66,-,-0.5688,0.042,-22.2419,-8.03111563380106,0.6702443162098956,Uncertain,0.999,pathogenic,-4.492,available,https://doi.org/10.1101/2022.10.22.513328 +M237Q,NP_000537:p.Met237Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.72677,0.9412553310394288,1.19422,1.2931906417204633,1.4604949999999999,1.5099803208602316,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.221,0.00172,,,,,-0.00158,,,10.5,,False,10.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.66,-,-0.443,0.042,-22.2419,-8.03111563380106,0.8531427398731435,Pathogenic,0.8954,pathogenic,-4.378,available,https://doi.org/10.1101/2022.10.22.513328 +M237R,NP_000537:p.Met237Arg,"hg19,17:g.7577571A>C, hg38,17:g.7674253A>C",,,0.948,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",419524,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.64734,2.398630142211914,1.73673,1.04617368118562,1.6920350000000002,1.34675684059281,Neutral,Neutral,Destabilizing,Neutral,Neutral,True,0.221,-0.2798,-0.05779,Neutral,,,-0.17862,0.16748,Neutral,10.5,,False,10.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.66,-,-0.4877,0.042,-22.2419,-6.92978894269953,0.8573582614168085,Pathogenic,0.9494,pathogenic,-4.312,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M237S,NP_000537:p.Met237Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.22072,1.810313105583191,2.51803,2.271148645331828,2.369375,2.245934322665914,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.221,0.01676,,,,,-0.00264,,,10.5,,False,10.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.66,-,-0.4292,0.042,-22.2419,-6.33030078337074,0.39559399894699,Uncertain,0.9559,pathogenic,-4.101,available,https://doi.org/10.1101/2022.10.22.513328 +M237T,NP_000537:p.Met237Thr,"hg19,17:g.7577571A>G, hg38,17:g.7674253A>G",,,0.948,"COSMIC,ClinVar,saturation_mutlist",481069,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.16194,1.8609520196914675,1.51701,1.5999177221645329,1.839475,1.8809288610822663,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.221,0.0433,-0.06945,Neutral,,,-0.005,-0.22506,Neutral,10.5,,False,10.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.66,-,-0.3012,0.042,-8.9541,-5.97821824318758,0.0253961230689375,Benign,0.9638,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M237V,NP_000537:p.Met237Val,"hg19,17:g.7577572T>C, hg19,17:g.7674254T>C, hg38,17:g.7674254T>C",,,0.937,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182934,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.71454,1.542583465576172,0.17245,0.4097599479638641,1.943495,2.0621499739819322,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,True,0.221,0.00836,0.07276,Neutral,,,-0.00564,0.20896,Neutral,10.5,,False,10.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.66,-,-0.3472,0.042,-22.2419,-4.22725305565164,0.2981978619328223,Benign,0.8096,pathogenic,-3.772,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M237W,NP_000537:p.Met237Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.77603,1.6442488431930542,-0.61905,-0.225929311398646,1.57849,1.775050344300677,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.221,0.10242,,,,,0.03597,,,10.5,,False,10.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.66,-,-0.4657,0.042,-22.2419,-7.06518272089547,0.8654221046411341,Pathogenic,0.9948,pathogenic,-4.764,available,https://doi.org/10.1101/2022.10.22.513328 +M237Y,NP_000537:p.Met237Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.11232,1.475317358970642,-0.70884,0.6032028794486268,2.70174,3.357761439724314,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,True,0.221,-0.01036,,,,,0.24054,,,10.5,,False,10.5,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.66,-,-0.4452,0.042,-22.2419,-6.67469361720534,0.6324763506857702,Uncertain,0.9854,pathogenic,-4.418,available,https://doi.org/10.1101/2022.10.22.513328 +C238A,NP_000537:p.Cys238Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.63205,-0.0866950750350952,1.21973,-0.5242659017509871,4.42589,3.553892049124506,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,True,0.216,0.08334,,,0.0,Neutral,0.00234,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.4925,0.0001,-22.239,-4.92685191703637,0.8708341942550044,Pathogenic,0.9995,pathogenic,-4.778,available,https://doi.org/10.1101/2022.10.22.513328 +C238D,NP_000537:p.Cys238Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.26143,0.6883544921875,-6.29116,0.2752811449693787,-0.5148649999999999,2.768355572484689,Uncertain,Uncertain,Neutral,Neutral,Uncertain,True,0.216,0.42204,,,-0.00939,Neutral,0.31045,,,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,damaging,True,damaging,neutral,97.08,S,-0.5998,0.0001,-22.239,-7.93506687281053,0.857659042722277,Pathogenic,0.9973,pathogenic,-4.806,available,https://doi.org/10.1101/2022.10.22.513328 +C238E,NP_000537:p.Cys238Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.28408,-0.1038825511932373,-4.13605,-0.1256554157385708,0.07401500000000016,2.079212292130715,Uncertain,Uncertain,Neutral,Neutral,Uncertain,True,0.216,0.86914,,,-0.01375,Neutral,0.17286,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.5874,0.0001,-22.239,-7.93506687281053,0.854971183449035,Pathogenic,0.9999,pathogenic,-4.957,available,https://doi.org/10.1101/2022.10.22.513328 +C238F,NP_000537:p.Cys238Phe,"hg19,17:g.7577568C>A, hg19,17:g.7674250C>A, hg38,17:g.7674250C>A",,,0.958,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376574,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,29.83388,1.4123926162719729,3.56224,-0.9586469712024348,16.69806,14.437616514398783,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.216,0.66792,-0.16543,Neutral,0.00599,Neutral,0.16179,0.26439,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.4865,0.0001,-22.239,-8.21030175526727,0.8616765651067589,Pathogenic,0.9996,pathogenic,-4.634,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C238G,NP_000537:p.Cys238Gly,"hg19,17:g.7577569A>C, hg19,17:g.7674251A>C, hg38,17:g.7674251A>C",,,0.938,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376577,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.67428,1.0312299728393557,3.69082,1.2041098633585503,6.18255,4.939194931679275,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.216,0.08868,-0.03107,Neutral,0.0,Neutral,0.00703,-0.02689,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.4849,0.0001,-22.239,-8.21030175526727,0.8704584281875574,Pathogenic,0.9956,pathogenic,-4.734,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C238H,NP_000537:p.Cys238His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,16.7583,0.7873687744140625,1.12449,-0.4023224765900862,8.941395,8.177988761704956,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,True,0.216,0.44204,,,0.0,Neutral,0.39993,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.5982,0.0001,-22.239,-8.21030175526727,0.8630942632464149,Pathogenic,0.9997,pathogenic,-4.763,available,https://doi.org/10.1101/2022.10.22.513328 +C238I,NP_000537:p.Cys238Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.24995,1.4923595190048218,2.14354,-0.8452561125230013,5.696745,4.202346943738499,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.216,0.09566,,,-0.0034,Neutral,0.0373,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.5163,0.0001,-22.239,-7.77406478768294,0.8682761041443985,Pathogenic,0.9999,pathogenic,-4.896,available,https://doi.org/10.1101/2022.10.22.513328 +C238K,NP_000537:p.Cys238Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,16.43168,1.8104177713394165,8.78197,0.9470260847635412,12.606825,8.689353042381772,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.216,-0.24056,,,0.01582,Neutral,-0.07406,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.588,0.0001,-22.239,-8.21030175526727,0.8684032593180526,Pathogenic,1.0,pathogenic,-4.912,available,https://doi.org/10.1101/2022.10.22.513328 +C238L,NP_000537:p.Cys238Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,11.59186,1.2737858295440674,-0.14864,-1.0501134970645587,5.72161,5.270873251467721,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.216,0.22588,,,0.0,Neutral,0.07078,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.5494,0.0001,-22.239,-7.77406478768294,0.8637393089590331,Pathogenic,0.9994,pathogenic,-4.751,available,https://doi.org/10.1101/2022.10.22.513328 +C238M,NP_000537:p.Cys238Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.51779,0.4858221411705017,1.48912,-0.5902634533476103,5.503455,4.463763273326195,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,True,0.216,0.17674,,,6e-05,Neutral,0.00426,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.5166,0.0001,-22.239,-7.77406478768294,0.8683052478293456,Pathogenic,0.9998,pathogenic,-4.87,available,https://doi.org/10.1101/2022.10.22.513328 +C238N,NP_000537:p.Cys238Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.86736,1.0092597007751465,-0.16735,0.0792115840618912,5.3500049999999995,5.4732857920309455,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.216,0.09754,,,0.0,Neutral,0.0152,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.5422,0.0001,-22.239,-7.93506687281053,0.8654010543595481,Pathogenic,0.9998,pathogenic,-4.781,available,https://doi.org/10.1101/2022.10.22.513328 +C238P,NP_000537:p.Cys238Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.85266,1.773672342300415,10.77551,6.438267883067459,10.814085,8.64546394153373,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.216,0.11466,,,0.0,Neutral,0.00567,,,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,damaging,True,damaging,neutral,97.08,S,-0.6108,0.0001,-22.239,-8.21030175526727,0.8685423719985923,Pathogenic,0.9999,pathogenic,-4.914,available,https://doi.org/10.1101/2022.10.22.513328 +C238Q,NP_000537:p.Cys238Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.89022,0.2634267807006836,-0.15408,-0.1580945560416624,4.8680699999999995,4.866062721979168,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,True,0.216,0.1749,,,0.0009,Neutral,-0.02768,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.5661,0.0001,-22.239,-7.93506687281053,0.8090215897349788,Pathogenic,1.0,pathogenic,-4.768,available,https://doi.org/10.1101/2022.10.22.513328 +C238R,NP_000537:p.Cys238Arg,"hg19,17:g.7577569A>G, hg19,17:g.7674251A>G, hg38,17:g.7674251A>G",,,0.954,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376576,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,21.1409,1.780427098274231,7.41667,0.3502613659903125,14.278785,10.745580682995156,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.216,-0.51418,0.1952,Neutral,0.02056,Neutral,-0.14543,-0.05671,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.5448,0.0001,-22.239,-8.21030175526727,0.8708431597106373,Pathogenic,0.9997,pathogenic,-4.7,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C238S,NP_000537:p.Cys238Ser,"hg19,17:g.7577568C>G, hg19,17:g.7577569A>T, hg19,17:g.7674250C>G, hg19,17:g.7674251A>T, hg38,17:g.7674250C>G, hg38,17:g.7674251A>T",,,"0.946, 0.956","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","485039, 376575","Conflicting classifications of pathogenicity, Pathogenic/Likely pathogenic","1, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.38406,0.2097288370132446,0.28231,0.4000920112620798,2.833185,2.89207600563104,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,True,0.216,0.06134,-0.02132,Neutral,1e-05,Neutral,0.00324,-0.03466,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.4833,0.0001,-22.239,-4.92685191703637,0.8609480651884298,Pathogenic,0.9996,pathogenic,-4.587,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C238T,NP_000537:p.Cys238Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.71262,0.5860570073127747,1.56531,-0.0588621822859081,4.638965,3.8268789088570463,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,True,0.216,0.02612,,,0.00549,Neutral,0.02483,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.5179,0.0001,-22.239,-4.92685191703637,0.86517533073567,Pathogenic,0.9998,pathogenic,-4.758,available,https://doi.org/10.1101/2022.10.22.513328 +C238V,NP_000537:p.Cys238Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.49122,0.7165499925613403,1.81531,-0.8491802409222299,6.153265,4.821019879538885,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,True,0.216,0.05564,,,-0.0037,Neutral,-0.02191,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.5144,0.0001,-22.239,-6.39664703324571,0.8499550722638951,Pathogenic,0.9994,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +C238W,NP_000537:p.Cys238Trp,"hg19,17:g.7577567A>C, hg19,17:g.7674249A>C, hg38,17:g.7674249A>C",,,0.896,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",161515,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,47.44158,1.1413960456848145,8.82415,-0.5957453709422789,28.132865000000002,23.42291731452886,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.216,1.04108,0.24233,Uncertain,0.02348,Neutral,0.21504,0.82918,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.4896,0.0001,-22.239,-8.21030175526727,0.8697837217553264,Pathogenic,0.9996,pathogenic,-4.767,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C238Y,NP_000537:p.Cys238Tyr,"hg19,17:g.7577568C>T, hg19,17:g.7674250C>T, hg38,17:g.7674250C>T",,7.9531084724e-06,0.957,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182935,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,37.29616,1.2445043325424194,3.97925,-0.6141595617053303,20.637705,18.341000219147336,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.216,0.3378,0.20851,Neutral,0.00477,Neutral,0.14692,0.10564,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,True,damaging,neutral,97.08,S,-0.4958,0.0001,-22.239,-8.21030175526727,0.8690336188448511,Pathogenic,0.9996,pathogenic,-4.662,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239A,NP_000537:p.Asn239Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.1179,0.7387408018112183,0.04184,0.6229706122000308,-0.03803,0.2525353061000154,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,-0.15668,,Uncertain,-0.13779,Neutral,0.13141,,Uncertain,36.3,,False,36.3,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,98.03,-,-0.325,0.0421,-22.239,-6.73670461250089,0.7792649874674429,Pathogenic,0.9892,pathogenic,-4.219,available,https://doi.org/10.1101/2022.10.22.513328 +N239C,NP_000537:p.Asn239Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.33771,-0.3344938158988952,0.34354,1.043898001178047,0.340625,0.6908040005890235,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,-0.1647,,Uncertain,-0.17599,Neutral,0.17157,,Uncertain,36.3,,False,36.3,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,98.03,-,-0.3749,0.0421,-22.239,-6.24538504464986,0.6933930531843053,Pathogenic,0.9452,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328 +N239D,NP_000537:p.Asn239Asp,"hg19,17:g.7577566T>C, hg19,17:g.7674248T>C, hg38,17:g.7674248T>C",,,0.948,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",234036,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.31902,0.6266383528709412,0.26905,0.4319622353978014,0.29403500000000005,0.3754911176989007,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,2.4085,0.13347,Uncertain,0.00612,Neutral,0.17231,0.65783,Neutral,36.3,,False,36.3,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,98.03,-,-0.3282,0.0421,-22.239,-4.51839023397795,0.8245311876138701,Pathogenic,0.9944,pathogenic,-4.34,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239E,NP_000537:p.Asn239Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.41409,0.3947055339813232,-5.93435,0.4194004958291825,-3.17422,0.0026552479145912355,Uncertain,Neutral,Neutral,Stabilizing,Neutral,False,0.117,1.94268,,Uncertain,0.47273,Neutral,0.97425,,Uncertain,36.3,,False,36.3,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,98.03,-,-0.3554,0.0421,-22.239,-4.51839023397795,0.8442157194287963,Pathogenic,0.9992,pathogenic,-4.502,available,https://doi.org/10.1101/2022.10.22.513328 +N239F,NP_000537:p.Asn239Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.98526,-1.0766582489013672,-1.75034,-1.0232932235105607,-1.8678,-1.5042766117552804,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.117,-1.4006,,Uncertain,-0.71895,Neutral,-0.05279,,Uncertain,36.3,,False,36.3,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,98.03,-,-0.3822,0.0421,-22.239,-4.41356815645093,0.3020670905389341,Benign,0.938,pathogenic,-3.997,available,https://doi.org/10.1101/2022.10.22.513328 +N239G,NP_000537:p.Asn239Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.75409,1.005553960800171,1.56531,1.5226896474619211,1.1597,1.1383898237309606,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.117,0.0239,,Uncertain,-0.03156,Neutral,0.32055,,Uncertain,36.3,,False,36.3,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,98.03,-,-0.3558,0.0421,-22.239,-7.49395404431902,0.6452406412705574,Uncertain,0.9841,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328 +N239H,NP_000537:p.Asn239His,"hg19,17:g.7577566T>G, hg38,17:g.7674248T>G",,,0.927,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.55736,-0.5881529450416565,-0.19354,-0.3183789662407843,-0.37544999999999995,-0.43786948312039214,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,-1.89904,-0.11733,Uncertain,-0.18548,Neutral,0.47527,0.09701,Neutral,36.3,,False,36.3,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,98.03,-,-0.2622,0.0421,-8.9511,-5.44224221544363,0.1094726625041875,Benign,0.8636,pathogenic,-3.902,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239I,NP_000537:p.Asn239Ile,"hg19,17:g.7577565T>A, hg38,17:g.7674247T>A",,,0.943,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2748594,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.61431,0.2668434977531433,-0.62347,-0.2509341975362034,-0.6188899999999999,-0.4326220987681017,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,1.45714,-0.27296,Uncertain,0.29137,Neutral,0.2482,0.27253,Neutral,36.3,,False,36.3,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,98.03,-,-0.3753,0.0421,-22.239,-5.7415489894666,0.8610894658864068,Pathogenic,0.9897,pathogenic,-4.473,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239K,NP_000537:p.Asn239Lys,"hg19,17:g.7577564G>C, hg19,17:g.7577564G>T, hg38,17:g.7674246G>C, hg38,17:g.7674246G>T",,,0.811,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","4189258, 385614","Pathogenic, Conflicting classifications of pathogenicity","1, 1",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.49724,0.6059909462928772,0.0483,0.6256142925698612,-0.22447,0.06418714628493061,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,-1.4748,0.01736,Uncertain,-0.15386,Neutral,0.31751,0.05951,Neutral,36.3,,False,36.3,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,98.03,-,-0.3282,0.0421,-22.239,-5.33968560339234,0.1284204288338064,Benign,0.9959,pathogenic,-3.783,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239L,NP_000537:p.Asn239Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.36662,0.1935779452323913,-1.27755,-0.8710921893044787,-1.322085,-1.1188560946522395,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,-0.73588,,Uncertain,-0.82152,Neutral,0.09416,,Uncertain,36.3,,False,36.3,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,98.03,-,-0.3817,0.0421,-22.239,-4.57202662186752,0.0740550907923182,Benign,0.8828,pathogenic,-3.818,available,https://doi.org/10.1101/2022.10.22.513328 +N239M,NP_000537:p.Asn239Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.34993,0.249297946691513,-1.34388,-0.3048950378090409,-1.346905,-0.8274125189045205,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,-0.37886,,Uncertain,-1.18188,Stabilizing,0.14027,,Uncertain,36.3,,False,36.3,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,98.03,-,-0.3359,0.0421,-22.239,-5.57183693448015,0.5869889111837324,Uncertain,0.9795,pathogenic,-4.224,available,https://doi.org/10.1101/2022.10.22.513328 +N239P,NP_000537:p.Asn239Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.58484,0.5545228719711304,0.78265,2.4098833161848727,-0.40109500000000003,0.41252165809243635,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.117,-0.0539,,Uncertain,-0.14547,Neutral,0.2181,,Uncertain,36.3,,False,36.3,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,98.03,-,-0.4906,0.0421,-22.239,-5.82620420376815,0.8664021515623944,Pathogenic,0.9854,pathogenic,-4.45,available,https://doi.org/10.1101/2022.10.22.513328 +N239Q,NP_000537:p.Asn239Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.00509,0.6389766931533813,-2.81156,0.3445858309026506,-1.403235,0.1748379154513253,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.117,-0.33782,,Uncertain,0.33878,Neutral,0.66832,,Uncertain,36.3,,False,36.3,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,98.03,-,-0.319,0.0421,-22.239,-4.51839023397795,0.728443676422765,Pathogenic,0.9932,pathogenic,-3.942,available,https://doi.org/10.1101/2022.10.22.513328 +N239R,NP_000537:p.Asn239Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.09761,0.3573699593544006,0.00068,0.1343018621825553,-0.048465,0.018345931091277648,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,-0.99052,,Uncertain,0.0805,Neutral,-0.91984,,Uncertain,36.3,,False,36.3,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,98.03,-,-0.3604,0.0421,-22.239,-5.04641763183701,0.3280496675686711,Uncertain,0.9885,pathogenic,-3.956,available,https://doi.org/10.1101/2022.10.22.513328 +N239S,NP_000537:p.Asn239Ser,"hg19,17:g.7577565T>C, hg19,17:g.7674247T>C, hg38,17:g.7674246_7674247inv, hg38,17:g.7674247T>C",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376637,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.13313,0.5112003087997437,-0.22653,0.8932872313661161,-0.046700000000000005,0.5132086156830581,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,-0.21924,-0.16892,Neutral,-0.45759,Neutral,0.07333,0.36818,Neutral,36.3,,False,36.3,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,98.03,-,-0.2271,0.0421,-8.9511,-4.23527283879432,0.3725484560732603,Uncertain,0.7939,pathogenic,-3.748,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239T,NP_000537:p.Asn239Thr,"hg19,17:g.7577565T>G, hg38,17:g.7674247T>G",,,0.935,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376638,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.7619,0.363760769367218,0.41224,0.6005408357385122,0.58707,0.6812204178692561,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,-0.04156,0.12219,Neutral,-0.5524,Neutral,0.41273,0.26071,Neutral,36.3,,False,36.3,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,98.03,-,-0.3445,0.0421,-22.239,-5.72677100872193,0.777712395277191,Pathogenic,0.9759,pathogenic,-4.007,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N239V,NP_000537:p.Asn239Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.43047,0.2661259472370147,-0.63878,0.1067208279486386,-0.534625,-0.16187458602568072,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,-0.39634,,Uncertain,-0.47412,Neutral,-0.05261,,Uncertain,36.3,,False,36.3,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,98.03,-,-0.3687,0.0421,-22.239,-5.7415489894666,0.7696121450409021,Pathogenic,0.9874,pathogenic,-4.324,available,https://doi.org/10.1101/2022.10.22.513328 +N239W,NP_000537:p.Asn239Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.70905,-0.6895630955696106,-0.42177,-1.3571955546403758,-0.56541,-1.0331227773201879,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.117,-0.68482,,Uncertain,-0.4384,Neutral,0.99245,,Uncertain,36.3,,False,36.3,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,98.03,-,-0.3873,0.0421,-22.239,-5.69964534233217,0.8592846433446831,Pathogenic,0.9928,pathogenic,-4.701,available,https://doi.org/10.1101/2022.10.22.513328 +N239Y,NP_000537:p.Asn239Tyr,"hg19,17:g.7577566T>A, hg38,17:g.7674248T>A",,,0.905,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.30756,-1.1629369258880615,-2.04558,-0.9162088020761366,-1.6765700000000001,-1.1118844010380684,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.117,-1.25778,-1.0152,Stabilizing,-0.49738,Neutral,0.08558,0.0227,Neutral,36.3,,False,36.3,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,98.03,-,-0.3657,0.0421,-22.239,-2.55273457862813,0.1664178693747725,Benign,0.8137,pathogenic,-4.024,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240A,NP_000537:p.Ser240Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.26813,1.0097929239273071,-0.17891,-0.1650899877943235,-0.22352,-0.21660999389716173,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.115,-0.0005,,,0.02979,Neutral,-0.00578,,,10.9,,False,10.9,,uncertain,,,-,uncertain,damaging,False,neutral,neutral,98.05,T,-0.2805,0.0001,-22.239,-4.74966987468903,0.8691517937731715,Pathogenic,0.9236,pathogenic,-4.204,available,https://doi.org/10.1101/2022.10.22.513328 +S240C,NP_000537:p.Ser240Cys,"hg19,17:g.7577563T>A, hg38,17:g.7674245T>A",,,0.923,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3972460,Likely pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.49666,0.6928735971450806,-0.55238,0.5562758505788892,-0.52452,0.029807925289444592,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.115,-0.03748,-0.04317,Neutral,0.00673,Neutral,-0.00684,-0.04048,Neutral,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.331,0.0001,-22.239,-4.74966987468903,0.8603000931140408,Pathogenic,0.965,pathogenic,-4.328,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240D,NP_000537:p.Ser240Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.5174,0.2035461664199829,0.90442,0.6691243709946334,0.19351000000000002,0.07586218549731671,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.115,0.69666,,,-0.10667,Neutral,-0.01527,,,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3792,0.0001,-22.239,-6.11525662181294,0.8708626127153459,Pathogenic,0.9988,pathogenic,-4.557,available,https://doi.org/10.1101/2022.10.22.513328 +S240E,NP_000537:p.Ser240Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.45923,0.956381380558014,0.71224,0.2608869399842628,0.12650499999999998,-0.0991715300078686,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.115,0.55112,,,-0.08374,Neutral,-0.0699,,,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3523,0.0001,-22.239,-6.11525662181294,0.8683016159752266,Pathogenic,0.9993,pathogenic,-4.708,available,https://doi.org/10.1101/2022.10.22.513328 +S240F,NP_000537:p.Ser240Phe,"hg19,17:g.7577562_7577563delinsAA, hg38,17:g.7674244_7674245delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.21335,1.2540700435638428,0.07381,-1.1576106788877287,0.6435799999999999,0.0278696605561356,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.115,0.03414,0.37848,Neutral,1.58562,Destabilizing,0.03268,0.00782,Neutral,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3585,0.0001,-22.239,-7.47258067390211,0.8512378421854259,Pathogenic,0.998,pathogenic,-4.6,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240G,NP_000537:p.Ser240Gly,"hg19,17:g.7577563T>C, hg19,17:g.7674245T>C, hg38,17:g.7674245T>C",,,0.872,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",584921,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.78731,1.0150113105773926,1.59864,1.1509336515524415,1.1929750000000001,0.9691218257762207,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.115,0.70604,0.10241,Neutral,0.1888,Neutral,0.01292,0.06117,Neutral,10.9,,False,10.9,,uncertain,,,DOWN,destabilizing,damaging,False,neutral,neutral,98.05,T,-0.2896,0.0001,-22.239,-4.8180146382902,0.4562981497441074,Uncertain,0.8955,pathogenic,-3.766,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240H,NP_000537:p.Ser240His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.22703,1.3175137042999268,0.11259,-0.5378553334826985,1.66981,1.3445873332586507,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.115,-0.07676,,,-0.06445,Neutral,-0.02785,,,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3598,0.0001,-22.239,-7.27200386010493,0.852665887818963,Pathogenic,0.9959,pathogenic,-4.361,available,https://doi.org/10.1101/2022.10.22.513328 +S240I,NP_000537:p.Ser240Ile,"hg19,17:g.7577562C>A, hg38,17:g.7674244C>A",,,0.883,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1036853,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-2.0881,1.2648334503173828,-1.24014,-0.9909791314701982,-1.66412,-1.539539565735099,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.115,-0.29914,0.15944,Neutral,0.10018,Neutral,-0.06195,-0.0122,Neutral,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3617,0.0001,-22.239,-4.94063288282226,0.6959523093181621,Pathogenic,0.9894,pathogenic,-4.272,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240K,NP_000537:p.Ser240Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28411,1.8516727685928345,2.35204,0.3841656732616433,1.318075,0.33413783663082164,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.115,-0.41596,,,0.31154,Neutral,-0.02174,,,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3691,0.0001,-22.239,-7.62779271728591,0.867154259992369,Pathogenic,0.9998,pathogenic,-4.49,available,https://doi.org/10.1101/2022.10.22.513328 +S240L,NP_000537:p.Ser240Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-2.38921,1.4355028867721558,-1.20476,-1.7606336448891555,-1.7969849999999998,-2.0749218224445776,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,False,0.115,-0.18602,,,0.02699,Neutral,-0.03599,,,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3579,0.0001,-22.239,-5.83198615151235,0.5988636034571956,Uncertain,0.9887,pathogenic,-4.366,available,https://doi.org/10.1101/2022.10.22.513328 +S240M,NP_000537:p.Ser240Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.86998,1.1480484008789062,-0.93912,-1.3015358558398098,-1.40455,-1.585757927919905,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.115,-0.1326,,,0.20699,Neutral,-0.03233,,,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.329,0.0001,-22.239,-6.80857538989954,0.8696082787686332,Pathogenic,0.9925,pathogenic,-4.594,available,https://doi.org/10.1101/2022.10.22.513328 +S240N,NP_000537:p.Ser240Asn,"hg19,17:g.7577562C>T, hg38,17:g.7674244C>T",,,0.750,"cBioPortal,ClinVar,saturation_mutlist",2502882,Pathogenic,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.50351,0.6663779020309448,0.05136,-0.0293972698038497,-0.226075,-0.26645363490192486,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.115,0.01018,-0.12607,Neutral,-0.01535,Neutral,-0.01366,0.179,Neutral,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3028,0.0001,-22.239,-5.00618289110594,0.2023934074144075,Benign,0.9618,pathogenic,-3.708,available,https://doi.org/10.1101/2022.10.22.513328 +S240P,NP_000537:p.Ser240Pro,"hg38,17:g.7674243_7674245delinsGGG",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.12872,2.1667234897613525,4.99694,4.87586190678961,4.06283,4.002290953394805,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.115,0.04126,-0.11227,Neutral,0.23447,Neutral,0.26352,-0.06759,Neutral,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.4339,0.0001,-22.239,-7.89312945800426,0.8687180525642478,Pathogenic,0.9978,pathogenic,-4.527,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240Q,NP_000537:p.Ser240Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.67587,1.1864845752716064,0.06905,-0.2257820410129751,-0.30340999999999996,-0.45082602050648757,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.115,-0.0136,,,0.0105,Neutral,-0.02448,,,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3224,0.0001,-22.239,-6.11525662181294,0.8647708597094842,Pathogenic,0.9982,pathogenic,-4.481,available,https://doi.org/10.1101/2022.10.22.513328 +S240R,NP_000537:p.Ser240Arg,"hg19,17:g.7577561A>C, hg19,17:g.7577561A>T, hg19,17:g.7577563T>G, hg19,17:g.7674243A>C, hg19,17:g.7674243A>T, hg38,17:g.7674243A>C, hg38,17:g.7674243A>T, hg38,17:g.7674245T>G",,,"0.908, 0.939","cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","1504304, 826894, 458559","Uncertain significance, Conflicting classifications of pathogenicity, Uncertain significance","2, 1, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.41349,1.7531428337097168,2.6619,-0.3714463091065967,2.0376950000000003,0.5210218454467016,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.115,-1.00398,-0.10705,Uncertain,0.78855,Neutral,-0.04963,0.02718,Neutral,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3743,0.0001,-22.239,-4.54427391360842,0.8630812922548369,Pathogenic,0.9995,pathogenic,-4.454,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240T,NP_000537:p.Ser240Thr,"hg38,17:g.7674244C>G",,,0.800,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.52203,-0.1366366147994995,-0.21599,-0.1389220517697009,-0.36901,-0.3304760258848505,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.115,-0.09378,0.08782,Neutral,-0.03143,Neutral,-0.0273,-0.00595,Neutral,10.9,,False,10.9,,neutral,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.2712,0.0001,-22.239,-3.64003872030778,0.022294891273976,Benign,0.8618,pathogenic,-3.712,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S240V,NP_000537:p.Ser240Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.22451,1.1956639289855957,-0.59184,-0.7356147530105517,-0.908175,-0.9800623765052758,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.115,-0.33696,,,0.05908,Neutral,-0.05788,,,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3359,0.0001,-22.239,-6.80857538989954,0.8676758737811677,Pathogenic,0.9935,pathogenic,-4.584,available,https://doi.org/10.1101/2022.10.22.513328 +S240W,NP_000537:p.Ser240Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.17658,0.9813329577445984,2.86633,-1.3408870302049374,2.021455,-0.08215351510246871,Uncertain,Neutral,Neutral,Uncertain,Neutral,False,0.115,1.35078,,,9.3103,Destabilizing,0.02302,,,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3682,0.0001,-22.239,-7.47258067390211,0.8649742272374237,Pathogenic,0.9972,pathogenic,-4.745,available,https://doi.org/10.1101/2022.10.22.513328 +S240Y,NP_000537:p.Ser240Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.32804,1.390014410018921,1.79218,-0.8191361251590412,1.06011,-0.2455480625795206,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.115,0.21624,,,3.74323,Destabilizing,0.11549,,,10.9,,False,10.9,,uncertain,,,UP,neutral,damaging,False,neutral,neutral,98.05,T,-0.3633,0.0001,-22.239,-7.47258067390211,0.8700907370140724,Pathogenic,0.9952,pathogenic,-4.639,available,https://doi.org/10.1101/2022.10.22.513328 +S241A,NP_000537:p.Ser241Ala,"hg19,17:g.7577560A>C, hg19,17:g.7674242A>C, hg38,17:g.7674242A>C",,,0.858,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376665,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.11548,0.3258934617042541,-0.0398,0.1926874173609433,-0.07764,0.03860370868047165,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,0.39228,0.67541,Neutral,0.52362,Neutral,-0.12947,0.0395,Neutral,66.0,,False,66.0,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,97.54,T,-0.2805,0.0001,-22.239,-4.92685191703637,0.8223519077022089,Pathogenic,0.9765,pathogenic,-4.111,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S241C,NP_000537:p.Ser241Cys,"hg19,17:g.7577559G>C, hg19,17:g.7674241G>C, hg38,17:g.7674241G>C",,0.0,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",177791,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15305,-0.008055567741394,0.38061,0.8434017533812757,0.11378,0.3451758766906378,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,0.4491,0.91826,Neutral,0.54632,Neutral,0.02478,0.20973,Neutral,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.331,0.0001,-22.239,-4.92685191703637,0.8692039119456415,Pathogenic,0.998,pathogenic,-4.397,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S241D,NP_000537:p.Ser241Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01718,-0.197467565536499,-0.28231,0.1029162390980364,-0.132565,0.0600481195490182,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,2.94474,,Uncertain,1.09239,Destabilizing,-0.37323,,Uncertain,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3792,0.0001,-22.239,-8.21030175526727,0.8497631074243504,Pathogenic,0.9997,pathogenic,-4.424,available,https://doi.org/10.1101/2022.10.22.513328 +S241E,NP_000537:p.Ser241Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.47318,0.5366343259811401,-0.49354,0.0529604321915311,-0.48336,-0.21010978390423446,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,2.16862,,Uncertain,0.94266,Neutral,-0.5101,,Uncertain,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3523,0.0001,-22.239,-8.21030175526727,0.8666231014963055,Pathogenic,0.9993,pathogenic,-4.744,available,https://doi.org/10.1101/2022.10.22.513328 +S241F,NP_000537:p.Ser241Phe,"hg19,17:g.7577558_7577559delinsAA, hg19,17:g.7577559G>A, hg19,17:g.7674240_7674241delinsAA, hg19,17:g.7674241G>A, hg38,17:g.7674240_7674241delinsAA, hg38,17:g.7674241G>A",,3.9765226105e-06,0.958,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12359,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.33698,0.6010681986808777,-0.59014,-0.8302661785143334,-0.12658,-0.2466430892571667,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,-0.38068,-0.02604,Neutral,-0.12674,Neutral,-0.5319,0.06133,Neutral,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3585,0.0001,-22.239,-8.21030175526727,0.8341106856063071,Pathogenic,0.999,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S241G,NP_000537:p.Ser241Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28631,-0.1196532249450683,0.60102,0.8071050928349177,0.443665,0.5467075464174589,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,1.35042,,Uncertain,0.88351,Neutral,0.18272,,Uncertain,66.0,,False,66.0,,uncertain,,,DOWN,neutral,neutral,False,neutral,neutral,97.54,T,-0.2896,0.0001,-22.239,-8.21030175526727,0.8691275895609734,Pathogenic,0.9958,pathogenic,-4.325,available,https://doi.org/10.1101/2022.10.22.513328 +S241H,NP_000537:p.Ser241His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.8552,0.4939649105072021,-0.70204,-0.5116182866013086,-0.77862,-0.6834091433006543,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,-0.78794,,Uncertain,0.4443,Neutral,-0.09448,,Uncertain,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3598,0.0001,-22.239,-8.21030175526727,0.8643708464289124,Pathogenic,0.9982,pathogenic,-4.548,available,https://doi.org/10.1101/2022.10.22.513328 +S241I,NP_000537:p.Ser241Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.25887,1.277382493019104,-0.10986,-0.2958370835300655,-0.184365,-0.27735354176503274,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.135,0.67112,,Uncertain,0.99642,Neutral,-0.47916,,Uncertain,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3617,0.0001,-22.239,-8.21030175526727,0.868601595457167,Pathogenic,0.9987,pathogenic,-4.617,available,https://doi.org/10.1101/2022.10.22.513328 +S241K,NP_000537:p.Ser241Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.18405,0.9262310266494752,0.38503,0.1985823457476992,0.10049,0.007266172873849605,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,-1.27662,,Uncertain,0.45181,Neutral,-0.17246,,Uncertain,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3691,0.0001,-22.239,-8.21030175526727,0.8670285198864858,Pathogenic,0.9998,pathogenic,-4.636,available,https://doi.org/10.1101/2022.10.22.513328 +S241L,NP_000537:p.Ser241Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.74315,1.2877485752105713,-0.5915,-0.617307546864509,-0.667325,-0.6802287734322545,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.135,-0.29302,,Uncertain,0.06394,Neutral,-0.59061,,Uncertain,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3579,0.0001,-22.239,-8.21030175526727,0.8627464186620517,Pathogenic,0.9987,pathogenic,-4.464,available,https://doi.org/10.1101/2022.10.22.513328 +S241M,NP_000537:p.Ser241Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.88211,0.9585803151130676,-0.86327,-0.1894599618837483,-0.87269,-0.5357849809418741,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,-0.33972,,Uncertain,-0.27406,Neutral,-0.4797,,Uncertain,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.329,0.0001,-22.239,-8.21030175526727,0.859208432163286,Pathogenic,0.999,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328 +S241N,NP_000537:p.Ser241Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22068,0.1491212844848632,-0.2,0.0671162591475377,0.010339999999999988,0.14389812957376885,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,-0.35006,,Uncertain,0.90796,Neutral,-0.2248,,Uncertain,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3028,0.0001,-22.239,-8.21030175526727,0.86889986823361,Pathogenic,0.9995,pathogenic,-4.342,available,https://doi.org/10.1101/2022.10.22.513328 +S241P,NP_000537:p.Ser241Pro,"hg19,17:g.7577560A>G, hg19,17:g.7674242A>G, hg38,17:g.7674242A>G",,3.9764593606e-06,0.954,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376664,Uncertain significance,1,Likely oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,-0.10458,1.4362425804138184,3.89252,1.9560375372406549,1.8939700000000002,0.9257287686203275,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.135,0.36784,1.44009,Uncertain,1.72266,Destabilizing,-0.24658,0.20884,Neutral,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.4339,0.0001,-22.239,-6.5576491183733,0.8708307029234279,Pathogenic,0.9981,pathogenic,-4.528,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S241Q,NP_000537:p.Ser241Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.51752,0.7413747310638428,-0.10952,0.3198539502301351,-0.31352,-0.09883302488493245,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,-0.01952,,Uncertain,0.69482,Neutral,-0.22449,,Uncertain,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3224,0.0001,-22.239,-8.21030175526727,0.8673136522121623,Pathogenic,0.9989,pathogenic,-4.495,available,https://doi.org/10.1101/2022.10.22.513328 +S241R,NP_000537:p.Ser241Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.05107,0.8643137216567993,0.41497,-0.2013770722413566,0.23302,-0.0751535361206783,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,-1.46984,,Uncertain,0.69621,Neutral,-0.0744,,Uncertain,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3743,0.0001,-22.239,-8.21030175526727,0.8464981781881484,Pathogenic,0.9996,pathogenic,-4.514,available,https://doi.org/10.1101/2022.10.22.513328 +S241T,NP_000537:p.Ser241Thr,"hg19,17:g.7577560A>T, hg38,17:g.7674242A>T",,,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",959232,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.4949,0.4490177035331726,-0.26429,0.2136698088474581,0.11530499999999999,0.35428490442372906,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,0.29816,0.6039,Neutral,0.07906,Neutral,-0.40134,-0.00493,Neutral,66.0,,False,66.0,,neutral,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.2712,0.0001,-22.239,-4.08804575809013,0.0750676283512807,Benign,0.9465,pathogenic,-3.75,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S241V,NP_000537:p.Ser241Val,,,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.0723,1.1779499053955078,-0.18401,-0.1810591976301218,-0.12815500000000002,-0.1266795988150609,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.135,0.26676,0.79322,Neutral,1.56494,Destabilizing,-0.38232,0.0036,Neutral,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3359,0.0001,-22.239,-8.21030175526727,0.8384857362251064,Pathogenic,0.9989,pathogenic,-4.484,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S241W,NP_000537:p.Ser241Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.82335,0.3148810267448425,-2.60204,-1.1973981797091915,-0.889345,-0.18702408985459573,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.135,0.1132,,Uncertain,-0.37936,Neutral,-0.42362,,Uncertain,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3682,0.0001,-22.239,-8.21030175526727,0.8704042824955825,Pathogenic,0.9954,pathogenic,-4.702,available,https://doi.org/10.1101/2022.10.22.513328 +S241Y,NP_000537:p.Ser241Tyr,"hg19,17:g.7577559G>T, hg19,17:g.7674241G>T, hg38,17:g.7674241G>T",,,0.960,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376663,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.31373,0.5481248497962952,-0.74014,-0.7419753671732887,-0.213205,-0.21412268358664435,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.135,-0.13288,-0.03628,Neutral,-0.01412,Neutral,-0.24312,-0.45658,Neutral,66.0,,False,66.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,97.54,T,-0.3633,0.0001,-22.239,-8.21030175526727,0.8662815261164071,Pathogenic,0.9984,pathogenic,-4.623,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C242A,NP_000537:p.Cys242Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.1778,0.0522162914276123,0.56259,-0.0546805010475343,0.870195,0.5615597494762328,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.115,0.25204,,,0.03002,Neutral,0.18308,,,20.2,,False,20.2,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,True,damaging,neutral,97.24,-,-0.4925,0.0001,-22.2361,-4.89657711428234,0.8570630110591773,Pathogenic,0.9992,pathogenic,-4.82,available,https://doi.org/10.1101/2022.10.22.513328 +C242D,NP_000537:p.Cys242Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.36082,0.0152622461318969,-5.57755,-0.1860256683867239,-3.4691849999999995,-0.7734228341933619,Uncertain,Neutral,Neutral,Stabilizing,Neutral,False,0.115,1.25998,,,-0.04751,Neutral,0.39093,,,20.2,,False,20.2,,neutral,neutral,neutral,-,uncertain,damaging,True,damaging,neutral,97.24,-,-0.5997,0.0001,-22.2361,-6.98373917109865,0.7096340668085412,Pathogenic,0.997,pathogenic,-4.626,available,https://doi.org/10.1101/2022.10.22.513328 +C242E,NP_000537:p.Cys242Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.0402,0.8758524656295776,-5.4585,-0.2027036885970629,-2.20915,0.41874815570146856,Uncertain,Neutral,Neutral,Uncertain,Neutral,False,0.115,2.70844,,,-0.01219,Neutral,0.53807,,,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.5874,0.0001,-22.2361,-7.61266223783693,0.8541913809997577,Pathogenic,0.9999,pathogenic,-4.986,available,https://doi.org/10.1101/2022.10.22.513328 +C242F,NP_000537:p.Cys242Phe,"hg19,17:g.7577555_7577556delinsAA, hg19,17:g.7577556C>A, hg19,17:g.7674238C>A, hg38,17:g.7674237_7674238delinsAA, hg38,17:g.7674238C>A",,,0.977,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376578,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.202,0.6457841396331787,-1.44456,0.0798809630921076,5.3787199999999995,6.140940481546054,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.115,0.03638,-0.71992,Neutral,0.05759,Neutral,0.78674,0.68258,Neutral,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.4865,0.0001,-22.2361,-8.15974944450928,0.8364706641668469,Pathogenic,0.9994,pathogenic,-4.749,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C242G,NP_000537:p.Cys242Gly,"hg19,17:g.7577557A>C, hg19,17:g.7674239A>C, hg38,17:g.7674239A>C",,,0.963,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376581,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.96515,1.1412583589553833,2.27959,0.8938453266661303,1.6223699999999999,0.9294976633330652,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.115,0.59412,0.03351,Neutral,0.04482,Neutral,0.23298,-0.29906,Neutral,20.2,,False,20.2,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,True,damaging,neutral,97.24,-,-0.4849,0.0001,-22.2361,-8.15974944450928,0.8636133106513612,Pathogenic,0.9973,pathogenic,-4.748,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C242H,NP_000537:p.Cys242His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.9268,0.8865451812744141,-0.85986,-0.0014836610508467,5.03347,5.462658169474577,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.115,0.78968,,,0.03813,Neutral,0.68865,,,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.5982,0.0001,-22.2361,-8.15974944450928,0.8630796700660601,Pathogenic,0.9995,pathogenic,-4.845,available,https://doi.org/10.1101/2022.10.22.513328 +C242I,NP_000537:p.Cys242Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.03309,0.5412817597389221,0.14286,-0.1220112276215834,2.0879749999999997,1.955539386189208,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.115,-0.31554,,,-0.05122,Neutral,0.19343,,,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.5163,0.0001,-22.2361,-8.15974944450928,0.8578664956517759,Pathogenic,0.9998,pathogenic,-4.967,available,https://doi.org/10.1101/2022.10.22.513328 +C242K,NP_000537:p.Cys242Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.47782,1.230918049812317,1.91803,0.6866687084198714,2.1979249999999997,1.5822443542099356,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.115,-0.2347,,,0.2458,Neutral,1.8204,,,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.588,0.0001,-22.2361,-8.15974944450928,0.8421538117312469,Pathogenic,1.0,pathogenic,-4.9,available,https://doi.org/10.1101/2022.10.22.513328 +C242L,NP_000537:p.Cys242Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.79717,0.8313828706741333,1.41565,-0.4432286159142246,1.60641,0.6769706920428877,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.115,0.00144,,,-0.02778,Neutral,1.49637,,,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.5494,0.0001,-22.2361,-8.15974944450928,0.8353222406037167,Pathogenic,0.9992,pathogenic,-4.894,available,https://doi.org/10.1101/2022.10.22.513328 +C242M,NP_000537:p.Cys242Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42546,0.7442073225975037,0.63946,-0.1184619541248033,1.03246,0.6534990229375983,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.115,-0.35294,,,0.00678,Neutral,-0.35073,,,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.5166,0.0001,-22.2361,-8.15974944450928,0.8708131135071031,Pathogenic,0.9996,pathogenic,-4.969,available,https://doi.org/10.1101/2022.10.22.513328 +C242N,NP_000537:p.Cys242Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.74665,0.654022753238678,-0.42551,-0.1632175786218803,1.1605699999999999,1.2917162106890598,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.115,0.33268,,,-0.00314,Neutral,-0.01353,,,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.5421,0.0001,-22.2361,-7.61266223783693,0.8699246610091091,Pathogenic,0.9997,pathogenic,-4.892,available,https://doi.org/10.1101/2022.10.22.513328 +C242P,NP_000537:p.Cys242Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.39096,1.180610179901123,6.73571,2.901625041122762,7.063335,5.146292520561381,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.115,0.4518,,,-0.00626,Neutral,-0.0518,,,20.2,,False,20.2,,neutral,neutral,neutral,-,uncertain,damaging,True,damaging,neutral,97.24,-,-0.6108,0.0001,-22.2361,-8.15974944450928,0.8640514187010842,Pathogenic,0.9997,pathogenic,-4.914,available,https://doi.org/10.1101/2022.10.22.513328 +C242Q,NP_000537:p.Cys242Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.96971,0.921136200428009,-1.32959,0.0902448347061052,0.82006,1.5299774173530527,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.115,1.18136,,,0.05194,Neutral,0.47161,,,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.5661,0.0001,-22.2361,-7.61266223783693,0.8706917840866089,Pathogenic,0.9999,pathogenic,-4.946,available,https://doi.org/10.1101/2022.10.22.513328 +C242R,NP_000537:p.Cys242Arg,"hg19,17:g.7577557A>G, hg19,17:g.7674239A>G, hg38,17:g.7674239A>G",,,0.966,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",449512,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.25907,1.2926568984985352,2.60102,0.2089331325261401,2.930045,1.73400156626307,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.115,-3.8206,0.03271,Uncertain,0.19877,Neutral,0.88203,0.45237,Neutral,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.5447,0.0001,-22.2361,-8.15974944450928,0.8339916451547135,Pathogenic,0.9994,pathogenic,-4.628,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C242S,NP_000537:p.Cys242Ser,"hg19,17:g.7577555_7577556delinsCG, hg19,17:g.7577555_7577556delinsTG, hg19,17:g.7577556C>G, hg19,17:g.7577557A>T, hg19,17:g.7674238C>G, hg19,17:g.7674239A>T, hg38,17:g.7674237_7674238delinsCG, hg38,17:g.7674237_7674238delinsTG, hg38,17:g.7674238C>G, hg38,17:g.7674239A>T",,,"0.947, 0.960","cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","2124706, 647334, 376579","Uncertain significance, Conflicting classifications of pathogenicity, Conflicting classifications of pathogenicity","1, 1, 1",,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.9568,-0.1690198183059692,-0.06667,0.2115455890302653,0.445065,0.5841727945151326,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.115,0.2436,0.10418,Neutral,-0.0032,Neutral,0.11653,-0.52916,Neutral,20.2,,False,20.2,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,True,damaging,neutral,97.24,-,-0.4833,0.0001,-22.2361,-3.52762339560825,0.8694505454316817,Pathogenic,0.9989,pathogenic,-4.542,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C242T,NP_000537:p.Cys242Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.94555,0.8217334747314453,0.1568,-0.1759750672366405,1.551175,1.3847874663816797,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.115,-0.22784,,,0.00692,Neutral,-0.08264,,,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.5179,0.0001,-22.2361,-4.89657711428234,0.856651120123094,Pathogenic,0.9996,pathogenic,-4.9,available,https://doi.org/10.1101/2022.10.22.513328 +C242V,NP_000537:p.Cys242Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.42477,0.5678722858428955,0.88197,-0.4205058892418006,2.1533700000000002,1.5021320553790998,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.115,-0.11988,,,0.00742,Neutral,0.08501,,,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.5144,0.0001,-22.2361,-8.15974944450928,0.8640438620631794,Pathogenic,0.9992,pathogenic,-4.865,available,https://doi.org/10.1101/2022.10.22.513328 +C242W,NP_000537:p.Cys242Trp,"hg19,17:g.7577555G>C, hg19,17:g.7674237G>C, hg38,17:g.7674237G>C",,,0.940,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376580,Pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,11.3471,0.4916264414787292,-1.56088,-0.0524850810853871,4.89311,5.6473074594573065,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.115,0.38228,-0.93027,Neutral,-0.12619,Neutral,3.61749,1.26666,Destabilizing,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.4896,0.0001,-22.2361,-8.15974944450928,0.8580461411782445,Pathogenic,0.9994,pathogenic,-4.76,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C242Y,NP_000537:p.Cys242Tyr,"hg19,17:g.7577555_7577556delinsAT, hg19,17:g.7577556C>T, hg19,17:g.7674238C>T, hg38,17:g.7674238C>T",,0.0,0.973,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12354,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,14.74352,0.6976812481880188,-0.85646,0.3253469409631998,6.94353,7.5344334704816,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.115,0.13154,-0.01126,Neutral,0.0571,Neutral,1.75997,0.85519,Uncertain,20.2,,False,20.2,,neutral,neutral,neutral,UP,neutral,damaging,True,damaging,neutral,97.24,-,-0.4958,0.0001,-22.2361,-8.15974944450928,0.8636054991225652,Pathogenic,0.9995,pathogenic,-4.664,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243A,NP_000537:p.Met243Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.02708,-0.3138510584831238,0.35306,0.3262666962300198,0.16299,0.1495933481150099,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,1.944,,Uncertain,0.27297,Neutral,1.45833,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,96.47,T,-0.3045,1.056,-22.239,-5.01571368090132,0.2705271604166983,Benign,0.9692,pathogenic,-3.732,available,https://doi.org/10.1101/2022.10.22.513328 +M243C,NP_000537:p.Met243Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.32029,-0.2695795893669128,1.28469,0.9136878691890638,0.80249,0.6169889345945319,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,1.83294,,Uncertain,0.30826,Neutral,1.632,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,96.47,T,-0.31,1.056,-22.239,-5.86290893037641,0.8105238359843054,Pathogenic,0.9876,pathogenic,-4.352,available,https://doi.org/10.1101/2022.10.22.513328 +M243D,NP_000537:p.Met243Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.13953,-0.1672863364219665,0.4881,0.1155225155975681,0.174285,-0.012003742201215944,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,3.08094,,Uncertain,0.293,Neutral,2.01196,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,96.47,T,-0.416,1.056,-22.239,-6.44610485232603,0.8579453457228781,Pathogenic,0.9989,pathogenic,-4.56,available,https://doi.org/10.1101/2022.10.22.513328 +M243E,NP_000537:p.Met243Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.40497,-0.1709744930267334,0.29694,-0.0113498020794566,-0.05401500000000001,-0.2081599010397283,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,2.55406,,Uncertain,0.27929,Neutral,1.71117,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,96.47,T,-0.4062,1.056,-22.239,-6.23220005976754,0.5954049090747371,Uncertain,0.9884,pathogenic,-4.275,available,https://doi.org/10.1101/2022.10.22.513328 +M243F,NP_000537:p.Met243Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.23454,0.0180088877677917,0.20238,-0.0542550206495395,0.21846,0.09014248967523025,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,0.4711,,Uncertain,-0.23064,Neutral,0.07434,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,96.47,T,-0.3096,1.056,-22.239,-6.43544119380032,0.7764778081234568,Pathogenic,0.9189,pathogenic,-3.902,available,https://doi.org/10.1101/2022.10.22.513328 +M243G,NP_000537:p.Met243Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30939,0.0700932443141937,1.20442,0.806111686749302,0.756905,0.557750843374651,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,2.87924,,Uncertain,0.27104,Neutral,2.55651,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,96.47,T,-0.3854,1.056,-22.239,-7.47274803967824,0.7877971953762282,Pathogenic,0.9883,pathogenic,-4.164,available,https://doi.org/10.1101/2022.10.22.513328 +M243H,NP_000537:p.Met243His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.21292,-0.1570801138877868,0.61395,-0.0451188274903852,0.413435,0.0839005862548074,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,1.0633,,Uncertain,0.59276,Neutral,0.24703,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,96.47,T,-0.3628,1.056,-22.239,-6.24617069068418,0.6912580603964245,Pathogenic,0.989,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328 +M243I,NP_000537:p.Met243Ile,"hg19,17:g.7577552C>A, hg19,17:g.7577552C>G, hg19,17:g.7577552C>T, hg19,17:g.7674234C>A, hg38,17:g.7674234C>A, hg38,17:g.7674234C>G, hg38,17:g.7674234C>T",,,0.820,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",840505,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.18432,-0.0507904887199401,0.19388,0.0092064472830383,0.1891,0.09676322364151915,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,0.06048,0.106,Neutral,0.3654,Neutral,1.08855,0.07628,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,96.47,T,-0.2218,1.056,-22.239,-3.86249283957872,0.3689489737561906,Uncertain,0.9829,pathogenic,-3.65,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243K,NP_000537:p.Met243Lys,"hg38,17:g.7674235A>T",,,0.933,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.06266,-0.1553996801376342,0.41429,0.0395428595553076,0.175815,-0.011558570222346198,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,1.13228,0.63763,Uncertain,0.17304,Neutral,1.01329,0.77236,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,96.47,T,-0.2993,1.056,-8.9511,-4.97557790620836,0.3794462245046546,Uncertain,0.9506,pathogenic,-4.159,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243L,NP_000537:p.Met243Leu,"hg19,17:g.7577554T>A, hg19,17:g.7577554T>G, hg38,17:g.7674236T>A, hg38,17:g.7674236T>G",,,0.763,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","1758050, 186653","Uncertain significance, Uncertain significance","2, 2",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.10612,-0.0623751282691955,0.16497,-0.2039943411349265,0.135545,-0.04893717056746325,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,0.12574,0.10641,Neutral,0.24803,Neutral,-0.10737,-0.10653,Neutral,96.7,,False,96.7,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,96.47,T,-0.1159,1.056,-7.9512,-0.913223744175104,0.2504216310607752,Benign,0.6754,pathogenic,-3.49,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243N,NP_000537:p.Met243Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.06895,-0.134840190410614,0.64456,0.3097359839421926,0.356755,0.1893429919710963,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,1.89646,,Uncertain,0.44286,Neutral,0.87364,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,96.47,T,-0.3576,1.056,-22.239,-5.8668624069445,0.4125255062321469,Uncertain,0.9802,pathogenic,-4.138,available,https://doi.org/10.1101/2022.10.22.513328 +M243P,NP_000537:p.Met243Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.22454,-0.8168572783470154,-0.62041,0.7860145955702166,-0.9224749999999999,-0.2192627022148917,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,1.55278,,Uncertain,0.2642,Neutral,0.63574,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,96.47,T,-0.4755,1.056,-22.239,-5.00011910575688,0.3867947875803377,Uncertain,0.9751,pathogenic,-3.872,available,https://doi.org/10.1101/2022.10.22.513328 +M243Q,NP_000537:p.Met243Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.23568,-0.1639387011528015,-0.05136,0.2962858055571671,0.09215999999999999,0.26598290277858355,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,1.60354,,Uncertain,0.2216,Neutral,0.90023,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,96.47,T,-0.2819,1.056,-8.9511,-4.5712167623987,0.0359161187859434,Benign,0.8333,pathogenic,-3.804,available,https://doi.org/10.1101/2022.10.22.513328 +M243R,NP_000537:p.Met243Arg,"hg38,17:g.7674235A>C",,,0.890,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.02673,-0.0314691662788391,0.49864,-0.0588008870269751,0.23595500000000003,-0.04276544351348755,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,0.80928,0.27018,Neutral,0.02539,Neutral,1.24804,0.42345,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,96.47,T,-0.3944,1.056,-22.239,-4.9510398083182,0.5258169918636857,Uncertain,0.9493,pathogenic,-3.996,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243S,NP_000537:p.Met243Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.1809,-0.2556416392326355,0.51395,0.3609370459173616,0.347425,0.2709185229586808,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,1.97462,,Uncertain,0.2895,Neutral,2.03906,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,96.47,T,-0.3359,1.056,-22.239,-5.13576018958961,0.4946064661989386,Uncertain,0.9552,pathogenic,-3.831,available,https://doi.org/10.1101/2022.10.22.513328 +M243T,NP_000537:p.Met243Thr,"hg19,17:g.7577553A>G, hg38,17:g.7674234_7674235inv, hg38,17:g.7674235A>G",,,0.879,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182936,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.21945,-0.0121302008628845,0.5551,0.2669166871920475,0.38727500000000004,0.24318334359602373,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,1.61764,0.43804,Uncertain,0.30881,Neutral,2.36616,1.2238,Destabilizing,96.7,,False,96.7,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,96.47,T,-0.2757,1.056,-22.239,-5.0814076128431,0.1530788127335997,Benign,0.9711,pathogenic,-3.612,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243V,NP_000537:p.Met243Val,"hg19,17:g.7577554T>C, hg38,17:g.7674236T>C",,,0.705,"COSMIC,ClinVar,saturation_mutlist",406567,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.26054,0.0193536877632141,0.39728,0.1614187988210957,0.32891000000000004,0.21097939941054783,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,0.93382,0.35531,Neutral,0.28486,Neutral,1.41858,0.53479,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,DOWN,destabilizing,damaging,False,neutral,neutral,96.47,T,-0.1445,1.056,-0.8117,-2.65749508073715,0.0642609487038819,Benign,0.6734,pathogenic,-3.246,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M243W,NP_000537:p.Met243Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.15779,0.0140011310577392,-0.17211,-0.3792834375079307,-0.00716,-0.11074671875396534,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,0.16,,Uncertain,-0.43076,Neutral,0.15473,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,96.47,T,-0.3724,1.056,-22.239,-5.41958305366638,0.8657860349896072,Pathogenic,0.9905,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +M243Y,NP_000537:p.Met243Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.19331,-0.0661353468894958,-0.07721,-0.0004225719267308,0.058050000000000004,0.0964437140366346,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.059,0.33536,,Uncertain,-0.07797,Neutral,0.31647,,Uncertain,96.7,,False,96.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,96.47,T,-0.3519,1.056,-22.239,-6.67656174183469,0.814276216251737,Pathogenic,0.9881,pathogenic,-4.19,available,https://doi.org/10.1101/2022.10.22.513328 +G244A,NP_000537:p.Gly244Ala,"hg19,17:g.7577550C>G, hg19,17:g.7674232C>G, hg38,17:g.7674232C>G",,,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458560,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.60467,1.2313201427459717,1.39796,1.2409337006027388,2.001315,1.9228018503013695,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.042,5.4433,0.37366,Uncertain,0.0,Neutral,0.14865,-0.16842,Neutral,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.3817,0.0211,-22.239,-6.16831376483764,0.7733710704049502,Pathogenic,0.9878,pathogenic,-4.14,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244C,NP_000537:p.Gly244Cys,"hg19,17:g.7577551C>A, hg19,17:g.7674233C>A, hg38,17:g.7674233C>A",,,0.940,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376599,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.64903,0.6652268171310425,1.80578,1.611828162538406,2.227405,2.1304290812692033,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.042,7.46342,1.11027,Destabilizing,-0.03147,Neutral,0.096,0.06762,Neutral,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4415,0.0211,-22.239,-6.16831376483764,0.8500422283408849,Pathogenic,0.9978,pathogenic,-4.44,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244D,NP_000537:p.Gly244Asp,"hg19,17:g.7577550C>T, hg19,17:g.7674232C>T, hg38,17:g.7674232C>T",,,0.953,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",372785,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.18992,1.3420881032943726,0.76054,0.4949763579251437,1.4752299999999998,1.3424481789625717,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.042,11.25853,2.31988,Destabilizing,-0.00097,Neutral,0.43275,-0.15729,Neutral,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.3742,0.0211,-8.9511,-7.29291234882808,0.0740398297691533,Benign,0.9987,pathogenic,-4.153,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244E,NP_000537:p.Gly244Glu,"hg38,17:g.7674231_7674232delinsTT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.17717,1.2550774812698364,1.2415,0.8987403473964994,1.7093349999999998,1.5379551736982497,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.042,9.70142,1.18323,Destabilizing,-0.00977,Neutral,0.21746,-0.14221,Neutral,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4413,0.0211,-22.239,-7.29291234882808,0.8168382547942192,Pathogenic,0.9993,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244F,NP_000537:p.Gly244Phe,"hg19,17:g.7577550_7577551delinsAA, hg38,17:g.7674232_7674233delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.2848,1.0154101848602295,0.7619,0.5092866422345055,2.02335,1.8970433211172528,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.042,9.40524,0.42414,Uncertain,-0.04599,Neutral,-0.47023,-0.33481,Neutral,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4796,0.0211,-22.239,-7.78169034861623,0.6673258987239299,Uncertain,0.9989,pathogenic,-4.502,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244H,NP_000537:p.Gly244His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.82675,1.0399352312088013,0.77007,0.2372641174388001,1.79841,1.5320070587194001,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.042,9.96847,,Uncertain,-0.283,Neutral,0.13284,,Uncertain,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4543,0.0211,-22.239,-7.78169034861623,0.6218315206652222,Uncertain,0.9997,pathogenic,-4.517,available,https://doi.org/10.1101/2022.10.22.513328 +G244I,NP_000537:p.Gly244Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.29312,1.7788753509521484,5.48027,2.037146941877439,5.386695,3.6651334709387196,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.042,11.43807,,Uncertain,-0.19763,Neutral,-0.25512,,Uncertain,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.5253,0.0211,-22.239,-7.51125204464897,0.8599543094008548,Pathogenic,0.9991,pathogenic,-4.626,available,https://doi.org/10.1101/2022.10.22.513328 +G244K,NP_000537:p.Gly244Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.23105,1.2734719514846802,0.72007,0.6628692338546183,1.4755600000000002,1.4469596169273093,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.042,7.16266,,Uncertain,-0.01914,Neutral,-0.03143,,Uncertain,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4742,0.0211,-22.239,-8.0521286525835,0.3524255528866486,Uncertain,0.9997,pathogenic,-4.316,available,https://doi.org/10.1101/2022.10.22.513328 +G244L,NP_000537:p.Gly244Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.94354,1.4046205282211304,0.96463,0.5464415147128271,1.454085,1.2449907573564136,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.042,7.95968,,Uncertain,0.05207,Neutral,-0.15525,,Uncertain,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4935,0.0211,-22.239,-6.98400098512006,0.6287823896698908,Uncertain,0.9985,pathogenic,-4.35,available,https://doi.org/10.1101/2022.10.22.513328 +G244M,NP_000537:p.Gly244Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.65209,1.2551109790802002,1.68163,0.7334277383979992,1.66686,1.1927588691989996,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.042,4.94652,,Uncertain,-0.02709,Neutral,-0.60998,,Uncertain,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4317,0.0211,-22.239,-7.51125204464897,0.7913737904473374,Pathogenic,0.9994,pathogenic,-4.44,available,https://doi.org/10.1101/2022.10.22.513328 +G244N,NP_000537:p.Gly244Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.67588,1.1587196588516235,0.44626,0.3243756909008155,1.56107,1.5001278454504077,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.042,6.8684,,Uncertain,0.0,Neutral,0.22083,,Uncertain,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4423,0.0211,-22.239,-7.29291234882808,0.7337909199878533,Pathogenic,0.9992,pathogenic,-4.294,available,https://doi.org/10.1101/2022.10.22.513328 +G244P,NP_000537:p.Gly244Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.45504,2.082249402999878,1.78673,6.207097347262485,4.120885,6.3310686736312425,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.042,7.79964,,Uncertain,-0.22878,Neutral,0.56349,,Uncertain,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.5394,0.0211,-22.239,-5.84144631749577,0.4529448455316377,Uncertain,0.9993,pathogenic,-4.13,available,https://doi.org/10.1101/2022.10.22.513328 +G244Q,NP_000537:p.Gly244Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.79317,1.2321385145187378,1.2034,0.9177322383219032,1.998285,1.8554511191609515,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.042,7.98248,,Uncertain,0.0,Neutral,0.29127,,Uncertain,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4452,0.0211,-22.239,-7.02115582267965,0.6703850315558944,Uncertain,0.9995,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328 +G244R,NP_000537:p.Gly244Arg,"hg19,17:g.7577551C>G, hg19,17:g.7674233C>G, hg38,17:g.7674233C>G",,,0.942,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3634428,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.04508,1.3108564615249634,1.46395,0.5309939943591632,2.254515,1.7880369971795815,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.042,7.57074,0.7564,Uncertain,0.0,Neutral,-0.50994,-0.09439,Neutral,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4583,0.0211,-22.239,-8.0521286525835,0.7856269786671234,Pathogenic,0.999,pathogenic,-4.24,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244S,NP_000537:p.Gly244Ser,"hg19,17:g.7577551C>T, hg19,17:g.7674233C>T, hg38,17:g.7674233C>T",,,0.936,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376600,Pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,3.12283,1.328291654586792,1.37415,1.257881208930887,2.24849,2.1903556044654433,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.042,5.45254,0.87639,Uncertain,0.0,Neutral,0.1451,-0.07345,Neutral,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.3876,0.0211,-22.239,-5.25612230183068,0.0181219299350898,Benign,0.9907,pathogenic,-3.724,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244T,NP_000537:p.Gly244Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.01284,1.3137755393981934,2.07415,1.858348721728976,3.543495,3.4355943608644877,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.042,10.28803,,Uncertain,0.0,Neutral,0.36162,,Uncertain,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4645,0.0211,-22.239,-5.26165082957476,0.0659943532966623,Benign,0.9952,pathogenic,-3.977,available,https://doi.org/10.1101/2022.10.22.513328 +G244V,NP_000537:p.Gly244Val,"hg19,17:g.7577550C>A, hg19,17:g.7674232C>A, hg38,17:g.7674232C>A",,,0.949,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376601,Likely pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.8614,1.805020093917847,6.04048,1.9908381854271289,5.950939999999999,3.9261190927135643,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.042,10.32967,2.21661,Destabilizing,-0.1046,Neutral,0.18555,-0.0284,Neutral,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4685,0.0211,-22.239,-7.51125204464897,0.8639126331446011,Pathogenic,0.9973,pathogenic,-4.394,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G244W,NP_000537:p.Gly244Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.84562,1.235895037651062,1.45136,0.2133475487184172,2.64849,2.0294837743592087,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.042,9.13064,,Uncertain,-0.07132,Neutral,0.03829,,Uncertain,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.4794,0.0211,-22.239,-7.78169034861623,0.854358503187032,Pathogenic,0.9984,pathogenic,-4.629,available,https://doi.org/10.1101/2022.10.22.513328 +G244Y,NP_000537:p.Gly244Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.2899,1.021521806716919,0.73673,0.5934174803790399,2.013315,1.9416587401895198,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.042,11.06546,,Uncertain,-0.07433,Neutral,-0.26857,,Uncertain,98.8,,False,98.8,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,93.39,T,-0.48,0.0211,-22.239,-7.78169034861623,0.8365961555364605,Pathogenic,0.9986,pathogenic,-4.696,available,https://doi.org/10.1101/2022.10.22.513328 +G245A,NP_000537:p.Gly245Ala,"hg19,17:g.7577546_7577547delinsTG, hg19,17:g.7577547C>G, hg19,17:g.7674229C>G, hg38,17:g.7674229C>G",,,0.946,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",265357,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.43715,1.5333397388458252,3.28878,0.5347565064255418,3.862965,2.485953253212771,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.032,0.32096,0.18956,Neutral,,,0.03577,0.15974,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.3817,0.0211,-22.239,-7.14246254602009,0.7238127307313789,Pathogenic,0.9856,pathogenic,-4.158,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245C,NP_000537:p.Gly245Cys,"hg19,17:g.7577548C>A, hg19,17:g.7674230C>A, hg38,17:g.7674230C>A",,,0.970,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12349,Pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,6.78633,1.49912691116333,5.24422,1.3574700019779191,6.015275000000001,4.071900000988959,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,0.32856,0.26345,Neutral,,,0.07275,0.06206,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,damaging,94.32,T,-0.4415,0.0211,-22.239,-7.14246254602009,0.8675127486874716,Pathogenic,0.9965,pathogenic,-4.497,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245D,NP_000537:p.Gly245Asp,"hg19,17:g.7577546_7577547delinsAT, hg19,17:g.7577547C>T, hg19,17:g.7674229C>T, hg38,17:g.7674228_7674229delinsAT, hg38,17:g.7674229C>T",,3.9767123723e-06,0.974,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","861760, 12355","Pathogenic, Pathogenic/Likely pathogenic","1, 2",,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,13.66246,2.1882011890411377,3.93537,1.5697768328912132,8.798915,7.616118416445606,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.032,1.03012,0.03004,Uncertain,,,0.25571,0.07088,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.442,0.0211,-22.239,-7.84612232477533,0.8583335949345794,Pathogenic,0.9989,pathogenic,-4.464,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245E,NP_000537:p.Gly245Glu,"hg38,17:g.7674228_7674229delinsTT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.93946,2.332871675491333,8.20374,1.9167833342192453,10.5716,7.428121667109623,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.032,0.93386,0.19205,Neutral,,,0.25461,-0.12258,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.4413,0.0211,-22.239,-7.13690041857986,0.7365059112341075,Pathogenic,0.9993,pathogenic,-4.388,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245F,NP_000537:p.Gly245Phe,"hg19,17:g.7577547_7577548delinsAA, hg38,17:g.7674229_7674230delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,19.1992,1.5789759159088137,9.65,1.186678064406166,14.424600000000002,10.192939032203084,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,0.35284,0.54136,Neutral,,,-0.02322,0.15968,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.4796,0.0211,-22.239,-8.11833508552484,0.781670790278806,Pathogenic,0.9987,pathogenic,-4.456,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245H,NP_000537:p.Gly245His,"hg38,17:g.7674229_7674230delinsTG",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,23.0782,1.901001214981079,8.72483,1.4256207700956085,15.901515,12.251910385047804,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,0.41046,0.28104,Neutral,,,0.30128,-0.18277,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.4543,0.0211,-22.239,-8.11833508552484,0.8548213574385146,Pathogenic,0.9997,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245I,NP_000537:p.Gly245Ile,"hg19,17:g.7577547_7577548delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,17.5388,2.005749464035034,1.61259,2.088703519894464,9.575695,9.81375175994723,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.032,0.3276,0.44106,Neutral,,,-0.034,-0.17688,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.5253,0.0211,-22.239,-8.11833508552484,0.8649891575274022,Pathogenic,0.9986,pathogenic,-4.527,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245K,NP_000537:p.Gly245Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,17.50122,2.114078521728516,12.35442,1.979021470232948,14.92782,9.740120735116474,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.032,0.22964,,,,,-0.02079,,,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.4742,0.0211,-22.239,-7.6868880675191,0.8000943518903343,Pathogenic,0.9995,pathogenic,-4.444,available,https://doi.org/10.1101/2022.10.22.513328 +G245L,NP_000537:p.Gly245Leu,"hg38,17:g.7674229_7674230delinsAG",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,16.27042,1.977890133857727,10.20306,0.6938714873308194,13.236740000000001,8.482145743665411,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,0.38338,0.34007,Neutral,,,0.05052,-0.16929,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.4935,0.0211,-22.239,-8.11833508552484,0.8678062587772928,Pathogenic,0.9988,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245M,NP_000537:p.Gly245Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.80782,1.7711864709854126,7.42381,0.8842757626276639,10.615815,7.346047881313832,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,0.43016,,,,,0.04789,,,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.4317,0.0211,-22.239,-8.11833508552484,0.8589987811206987,Pathogenic,0.9993,pathogenic,-4.565,available,https://doi.org/10.1101/2022.10.22.513328 +G245N,NP_000537:p.Gly245Asn,"hg19,17:g.7577547_7577548delinsTT, hg38,17:g.7674229_7674230delinsTT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,15.10278,2.074125289916992,6.46803,0.9625039048714428,10.785404999999999,8.032641952435721,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.032,0.39308,0.10985,Neutral,,,0.08738,0.02837,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.4423,0.0211,-22.239,-7.84612232477533,0.863482507871034,Pathogenic,0.9988,pathogenic,-4.231,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245P,NP_000537:p.Gly245Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,16.30238,1.9886549711227417,12.36939,5.275202632635374,14.335885,10.788791316317687,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.032,0.9174,,,,,0.89489,,,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.5394,0.0211,-22.239,-8.11833508552484,0.8599737772626729,Pathogenic,0.9998,pathogenic,-4.65,available,https://doi.org/10.1101/2022.10.22.513328 +G245Q,NP_000537:p.Gly245Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,17.20902,2.064891815185547,8.12075,1.3934724872143105,12.664884999999998,9.301246243607155,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.032,0.3682,,,,,0.07648,,,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.4452,0.0211,-22.239,-7.84612232477533,0.8539753030692447,Pathogenic,0.9994,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +G245R,NP_000537:p.Gly245Arg,"hg19,17:g.7577548C>G, hg19,17:g.7674230C>G, hg38,17:g.7674230C>G",,0.0,0.961,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376604,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,25.65244,1.9353471994400024,12.45408,1.4236613278415244,19.053259999999998,13.538050663920762,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,-0.02312,0.32863,Neutral,,,-0.03041,0.10824,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.3905,0.0211,-8.9511,-5.02711372287612,0.4241063623239255,Uncertain,0.9987,pathogenic,-4.402,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245S,NP_000537:p.Gly245Ser,"hg19,17:g.7577548C>T, hg19,17:g.7674230C>T, hg38,17:g.7674230C>T",3.19284802043e-05,0.0,0.947,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12365,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,5.17626,1.822721242904663,2.5051,1.1415551461564122,3.84068,3.1589075730782064,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,-0.11234,0.07577,Neutral,,,0.03561,0.16082,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.3876,0.0211,-22.239,-5.81833350582095,0.0590408480555328,Benign,0.9732,pathogenic,-3.798,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245T,NP_000537:p.Gly245Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.18637,1.94617760181427,2.50748,1.6217571161306712,6.346925000000001,5.904063558065336,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,0.42662,,,,,0.17704,,,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.4645,0.0211,-22.239,-7.14246254602009,0.6191797514730958,Uncertain,0.9952,pathogenic,-4.278,available,https://doi.org/10.1101/2022.10.22.513328 +G245V,NP_000537:p.Gly245Val,"hg19,17:g.7577546_7577547delinsAA, hg19,17:g.7577547C>A, hg19,17:g.7674229C>A, hg38,17:g.7674228_7674229delinsAA, hg38,17:g.7674229C>A",,3.9767123723e-06,0.972,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376603,Pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,11.96504,1.95527982711792,4.11293,1.8116833624778648,8.038985,6.8883616812389326,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,0.46904,0.57449,Neutral,,,0.25584,0.19056,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.4685,0.0211,-22.239,-8.11833508552484,0.8486102610890538,Pathogenic,0.9969,pathogenic,-4.535,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G245W,NP_000537:p.Gly245Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,38.81636,1.7245008945465088,12.88707,1.534367699441482,25.851715000000002,20.175363849720743,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,0.42094,,,,,0.18287,,,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.4794,0.0211,-22.239,-8.11833508552484,0.8432927137407036,Pathogenic,0.9986,pathogenic,-4.634,available,https://doi.org/10.1101/2022.10.22.513328 +G245Y,NP_000537:p.Gly245Tyr,"hg19,17:g.7577547_7577548delinsTA",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,23.2731,1.6225366592407229,11.24626,1.559510890635533,17.25968,12.416305445317766,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.032,0.34884,-0.07486,Neutral,,,-0.06823,0.54838,Neutral,9.7,,False,9.7,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,94.32,T,-0.48,0.0211,-22.239,-8.11833508552484,0.8673725117607469,Pathogenic,0.9989,pathogenic,-4.711,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246A,NP_000537:p.Met246Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.62966,0.9278081059455872,2.21905,2.530340259719197,2.4243550000000003,2.5800001298595987,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.025,-0.01104,,,-0.00163,Neutral,0.50501,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.83,T,-0.3997,0.0212,-22.2332,-7.57609653582207,0.8694803141701529,Pathogenic,0.9964,pathogenic,-4.262,available,https://doi.org/10.1101/2022.10.22.513328 +M246C,NP_000537:p.Met246Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.72491,0.4333235025405884,2.6449,2.6672150708332034,2.6849049999999997,2.6960625354166017,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.025,0.0026,,,-0.00163,Neutral,-0.01088,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.83,T,-0.4052,0.0212,-22.2332,-7.57609653582207,0.8507348962555651,Pathogenic,0.9961,pathogenic,-4.528,available,https://doi.org/10.1101/2022.10.22.513328 +M246D,NP_000537:p.Met246Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.44608,1.4950459003448486,2.89456,3.78902846023758,3.17032,3.61755423011879,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.025,0.3069,,,-0.03854,Neutral,0.03265,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.83,T,-0.5112,0.0212,-22.2332,-7.17281793689777,0.8699002421577389,Pathogenic,0.9998,pathogenic,-4.761,available,https://doi.org/10.1101/2022.10.22.513328 +M246E,NP_000537:p.Met246Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.63293,1.6444522142410278,2.11837,3.228395039372568,2.3756500000000003,2.930662519686284,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.025,0.45256,,,-0.03121,Neutral,-0.03106,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.83,T,-0.5014,0.0212,-22.2332,-7.17281793689777,0.8708581528396837,Pathogenic,0.9982,pathogenic,-4.546,available,https://doi.org/10.1101/2022.10.22.513328 +M246F,NP_000537:p.Met246Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.16842,0.8721894025802612,0.5949,1.0188382578191515,2.88166,3.093629128909576,Uncertain,Uncertain,Neutral,Uncertain,Destabilizing,False,0.025,-0.01088,,,0.00643,Neutral,0.01102,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,96.83,T,-0.4048,0.0212,-22.2332,-6.91837746985783,0.8629994461885333,Pathogenic,0.9615,pathogenic,-4.336,available,https://doi.org/10.1101/2022.10.22.513328 +M246G,NP_000537:p.Met246Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.97833,1.800698161125183,3.77585,4.382474671061454,3.87709,4.180402335530727,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.025,0.62392,,,-0.00174,Neutral,0.47522,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.83,T,-0.4806,0.0212,-22.2332,-7.57609653582207,0.8630812922548369,Pathogenic,0.9984,pathogenic,-4.444,available,https://doi.org/10.1101/2022.10.22.513328 +M246H,NP_000537:p.Met246His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.90792,1.55859637260437,1.70374,2.355020630574084,2.80583,3.131470315287042,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,False,0.025,0.0268,,,0.00926,Neutral,-0.00031,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.83,T,-0.458,0.0212,-22.2332,-6.28560768788161,0.6524611313234762,Uncertain,0.999,pathogenic,-4.046,available,https://doi.org/10.1101/2022.10.22.513328 +M246I,NP_000537:p.Met246Ile,"hg19,17:g.7577543C>A, hg19,17:g.7577543C>G, hg19,17:g.7577543C>T, hg19,17:g.7674225C>A, hg19,17:g.7674225C>G, hg19,17:g.7674225C>T, hg38,17:g.7674225C>A, hg38,17:g.7674225C>G, hg38,17:g.7674225C>T",,,0.838,"cBioPortal,COSMIC,ClinVar,ClinVar,ClinVar,saturation_mutlist","1758655, 968639, 480961","Likely pathogenic, Conflicting classifications of pathogenicity, Pathogenic/Likely pathogenic","1, 1, 2",Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.73925,-0.1157824993133544,-0.13503,0.3154812807059853,0.80211,1.0273656403529927,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,-0.04494,0.23436,Neutral,0.00036,Neutral,0.00035,0.03475,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,96.83,T,-0.2492,0.0212,-8.9453,-3.37572060739883,0.2999832334585663,Benign,0.9793,pathogenic,-3.636,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246K,NP_000537:p.Met246Lys,"hg19,17:g.7577544A>T, hg19,17:g.7674226A>T, hg38,17:g.7674226A>T",,,0.963,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",480764,Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.93376,1.5527665615081787,3.34592,3.728194774414013,3.13984,3.3309773872070068,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.025,-0.32454,-0.14861,Neutral,0.03893,Neutral,-0.0482,-0.00177,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,96.83,T,-0.4623,0.0212,-22.2332,-7.57609653582207,0.8688500462607078,Pathogenic,0.9922,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246L,NP_000537:p.Met246Leu,"hg19,17:g.7577545T>A, hg19,17:g.7577545T>G, hg38,17:g.7674227T>A, hg38,17:g.7674227T>G",,,0.865,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","406586, 186737","Uncertain significance, Conflicting classifications of pathogenicity","1, 1",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.08436,-0.1114364862442016,0.7585,-0.0116802312690061,0.33707,-0.04802011563450305,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.025,-0.04428,-0.05202,Neutral,0.00139,Neutral,0.00137,-0.19895,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,96.83,T,-0.284,0.0212,-22.2332,-3.25823119973457,0.4449429887498569,Uncertain,0.8684,pathogenic,-3.535,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246N,NP_000537:p.Met246Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.39889,1.5954278707504272,2.75136,2.5356003998948773,3.075125,2.9672451999474387,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.025,0.02632,,,-0.00534,Neutral,-0.00816,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.83,T,-0.4528,0.0212,-22.2332,-7.17281793689777,0.8461018634662261,Pathogenic,0.9977,pathogenic,-4.506,available,https://doi.org/10.1101/2022.10.22.513328 +M246P,NP_000537:p.Met246Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14172,1.0039483308792114,2.17993,4.540848789382809,1.160825,2.341284394691405,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,False,0.025,0.11168,,,0.00768,Neutral,0.03641,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.83,T,-0.5707,0.0212,-22.2332,-4.75677619411136,0.4173386498972297,Uncertain,0.9767,pathogenic,-3.864,available,https://doi.org/10.1101/2022.10.22.513328 +M246Q,NP_000537:p.Met246Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.19348,1.0567445755004885,0.51259,2.2829788080031896,1.353035,2.238229404001595,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,False,0.025,-0.0812,,,0.00377,Neutral,-0.00199,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.83,T,-0.4449,0.0212,-22.2332,-6.33201696677918,0.8651390951041079,Pathogenic,0.9839,pathogenic,-4.056,available,https://doi.org/10.1101/2022.10.22.513328 +M246R,NP_000537:p.Met246Arg,"hg19,17:g.7577544A>C, hg19,17:g.7674226A>C, hg38,17:g.7674226A>C",,,0.959,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127822,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.78124,1.7087982892990112,3.04014,2.684230268995856,3.91069,3.7327351344979283,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.025,-0.45212,-0.02021,Neutral,0.19997,Neutral,-0.02613,0.0222,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,96.83,T,-0.4896,0.0212,-22.2332,-7.57609653582207,0.8706269961166653,Pathogenic,0.9949,pathogenic,-4.442,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246S,NP_000537:p.Met246Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.42441,1.0572625398635864,3.36701,3.446526562947044,3.3957100000000002,3.435468281473522,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.025,-0.0453,,,0.00204,Neutral,0.5127,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.83,T,-0.4311,0.0212,-22.2332,-7.57609653582207,0.8708481666523378,Pathogenic,0.9967,pathogenic,-4.372,available,https://doi.org/10.1101/2022.10.22.513328 +M246T,NP_000537:p.Met246Thr,"hg19,17:g.7577544A>G, hg19,17:g.7674226A>G, hg38,17:g.7674226A>G",,,0.956,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428886,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.52581,0.9887477159500122,2.28673,2.3740095793949725,2.40627,2.449909789697486,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.025,0.0499,0.0219,Neutral,0.00695,Neutral,-0.00243,0.00805,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.83,T,-0.3709,0.0212,-22.2332,-7.57609653582207,0.8655652021841689,Pathogenic,0.9983,pathogenic,-4.167,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246V,NP_000537:p.Met246Val,"hg19,17:g.7577545T>C, hg19,17:g.7674227T>C, hg38,17:g.7674227T>C",,,0.924,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",100815,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.23264,0.3323191404342651,0.95476,0.6278942381993441,1.5937000000000001,1.430267119099672,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.025,0.05046,0.05985,Neutral,0.00533,Neutral,-0.00856,-0.02837,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,mixed_effects,damaging,False,neutral,neutral,96.83,T,-0.3491,0.0212,-22.2332,-4.00168503980769,0.7981215455602353,Pathogenic,0.9304,pathogenic,-4.012,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +M246W,NP_000537:p.Met246Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.94216,0.978490710258484,0.19762,1.8023273650875653,3.56989,4.3722436825437825,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.025,0.0249,,,0.00503,Neutral,0.39805,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,96.83,T,-0.4676,0.0212,-22.2332,-6.91837746985783,0.8677817171101401,Pathogenic,0.9977,pathogenic,-4.588,available,https://doi.org/10.1101/2022.10.22.513328 +M246Y,NP_000537:p.Met246Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.05611,1.208235740661621,1.78265,1.9251774741086207,5.41938,5.49064373705431,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.025,-0.01128,,,-0.00105,Neutral,0.00022,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,stabilizing,damaging,False,neutral,neutral,96.83,T,-0.4471,0.0212,-22.2332,-6.91837746985783,0.8706790787559304,Pathogenic,0.998,pathogenic,-4.504,available,https://doi.org/10.1101/2022.10.22.513328 +N247A,NP_000537:p.Asn247Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.259,0.589370608329773,1.35748,0.8134104678342277,0.8082400000000001,0.5362052339171138,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.11944,,Uncertain,-0.09691,Neutral,0.06522,,Uncertain,66.1,,False,66.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,T,-0.325,0.0422,-22.2332,-6.36434781999315,0.8092996302264369,Pathogenic,0.9822,pathogenic,-4.236,available,https://doi.org/10.1101/2022.10.22.513328 +N247C,NP_000537:p.Asn247Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.55288,0.2749215364456177,1.5068,1.2241937873601645,1.02984,0.8885368936800823,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,0.01374,,Uncertain,-0.10008,Neutral,0.02723,,Uncertain,66.1,,False,66.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,T,-0.3749,0.0422,-22.2332,-6.36434781999315,0.8688034838822214,Pathogenic,0.9642,pathogenic,-4.431,available,https://doi.org/10.1101/2022.10.22.513328 +N247D,NP_000537:p.Asn247Asp,"hg19,17:g.7577542T>C, hg38,17:g.7674224T>C",,,0.940,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.79677,0.4005680084228515,0.40068,0.5193563420988542,-0.198045,-0.1387068289505729,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,1.80154,1.23465,Destabilizing,0.04703,Neutral,-0.26525,-0.17503,Neutral,66.1,,False,66.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.3,T,-0.3282,0.0422,-22.2332,-4.41228490946553,0.6938272135596166,Pathogenic,0.9854,pathogenic,-4.162,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N247E,NP_000537:p.Asn247Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.30678,0.5641512870788574,0.48095,0.5934487756601792,0.087085,0.1433343878300896,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,1.56464,,Uncertain,-0.04133,Neutral,-0.20484,,Uncertain,66.1,,False,66.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,T,-0.3553,0.0422,-22.2332,-4.73180277798174,0.7979720528934758,Pathogenic,0.9975,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328 +N247F,NP_000537:p.Asn247Phe,"hg38,17:g.7674223_7674224inv",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.04252,1.197124719619751,0.87891,0.0996345652552571,0.460715,0.07107728262762855,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.031,1.5935,0.31683,Uncertain,0.03995,Neutral,-0.80606,-0.03416,Neutral,66.1,,False,66.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,T,-0.3821,0.0422,-22.2332,-7.61411973536705,0.8628638146712628,Pathogenic,0.9967,pathogenic,-4.63,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N247G,NP_000537:p.Asn247Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.61782,0.3309115171432495,2.11088,1.3965745881339344,1.36435,1.0071972940669673,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.031,0.63188,,Uncertain,-0.16194,Neutral,-0.0074,,Uncertain,66.1,,False,66.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,T,-0.3558,0.0422,-22.2332,-5.81347888632858,0.5395502784258973,Uncertain,0.9589,pathogenic,-4.13,available,https://doi.org/10.1101/2022.10.22.513328 +N247H,NP_000537:p.Asn247His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.43163,0.5537011027336121,0.78265,0.2559799903807497,0.60714,0.3438049951903749,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,1.49736,,Uncertain,0.43989,Neutral,0.00635,,Uncertain,66.1,,False,66.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,T,-0.2621,0.0422,-8.9453,-7.34455894760834,0.3711428744214047,Uncertain,0.9627,pathogenic,-3.964,available,https://doi.org/10.1101/2022.10.22.513328 +N247I,NP_000537:p.Asn247Ile,"hg19,17:g.7577540_7577541delinsTA, hg19,17:g.7577541T>A, hg19,17:g.7674223T>A, hg38,17:g.7674222_7674223delinsTA, hg38,17:g.7674223T>A",,,0.953,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",184882,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.94084,1.8797357082366943,5.00204,0.4554241471765413,3.47144,1.1981320735882706,Uncertain,Neutral,Uncertain,Destabilizing,Neutral,False,0.031,0.25188,2.49411,Uncertain,-0.06263,Neutral,-0.12692,0.04069,Neutral,66.1,,False,66.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,T,-0.3753,0.0422,-22.2332,-7.87845834414539,0.8702166051453897,Pathogenic,0.9966,pathogenic,-4.564,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N247K,NP_000537:p.Asn247Lys,"hg38,17:g.7674222G>T",,,0.889,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.24968,0.9086021780967712,1.4398,0.5752974902982829,0.84474,0.41248874514914147,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,-0.62212,1.40992,Uncertain,-0.1483,Neutral,-0.11435,0.08484,Neutral,66.1,,False,66.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,T,-0.3282,0.0422,-22.2332,-7.87845834414539,0.8690366775415297,Pathogenic,0.9975,pathogenic,-4.39,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N247L,NP_000537:p.Asn247Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.1814,1.2790496349334717,1.07075,0.0020545254669768,0.626075,0.0917272627334884,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.031,-0.84052,,Uncertain,-0.05824,Neutral,-0.33998,,Uncertain,66.1,,False,66.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,T,-0.3817,0.0422,-22.2332,-7.87845834414539,0.8596028519049006,Pathogenic,0.9846,pathogenic,-4.511,available,https://doi.org/10.1101/2022.10.22.513328 +N247M,NP_000537:p.Asn247Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.33997,0.8517357110977173,1.59286,0.3612926257484894,0.966415,0.3506313128742447,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,-0.70254,,Uncertain,-0.10008,Neutral,-0.57424,,Uncertain,66.1,,False,66.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,T,-0.3358,0.0422,-22.2332,-7.87845834414539,0.8707380504552522,Pathogenic,0.9859,pathogenic,-4.388,available,https://doi.org/10.1101/2022.10.22.513328 +N247P,NP_000537:p.Asn247Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.4479,2.214584350585937,5.83946,4.224317152319153,7.14368,6.336108576159576,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.031,1.91128,,Uncertain,-0.08432,Neutral,0.03587,,Uncertain,66.1,,False,66.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.3,T,-0.4906,0.0422,-22.2332,-7.87845834414539,0.8639695214352283,Pathogenic,0.997,pathogenic,-4.594,available,https://doi.org/10.1101/2022.10.22.513328 +N247Q,NP_000537:p.Asn247Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.07583,0.5920473337173462,1.08639,0.8224405904555795,0.58111,0.4491352952277897,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.031,1.03274,,Uncertain,-0.10008,Neutral,-0.18204,,Uncertain,66.1,,False,66.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,T,-0.319,0.0422,-22.2332,-4.28863931983678,0.4672364226767995,Uncertain,0.9892,pathogenic,-3.972,available,https://doi.org/10.1101/2022.10.22.513328 +N247R,NP_000537:p.Asn247Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.80453,1.0604958534240725,1.48027,0.274119015299743,1.1423999999999999,0.5393245076498715,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.031,-2.048,,Uncertain,-0.2185,Neutral,0.1917,,Uncertain,66.1,,False,66.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,T,-0.3604,0.0422,-22.2332,-7.87845834414539,0.7739433747485658,Pathogenic,0.9938,pathogenic,-4.376,available,https://doi.org/10.1101/2022.10.22.513328 +N247S,NP_000537:p.Asn247Ser,"hg19,17:g.7577541T>C, hg38,17:g.7674223T>C",,,0.935,"COSMIC,ClinVar,saturation_mutlist",406595,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.09142,0.5003986954689026,2.17007,0.9526242045753428,1.6307450000000001,1.0220221022876714,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.031,0.7786,1.27055,Uncertain,-0.04055,Neutral,0.20017,0.21779,Neutral,66.1,,False,66.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.3,T,-0.2271,0.0422,-8.9453,-3.85136361305547,0.056724193748996,Benign,0.7867,pathogenic,-3.686,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N247T,NP_000537:p.Asn247Thr,"hg19,17:g.7577541T>G, hg19,17:g.7674223T>G, hg38,17:g.7674223T>G",,,0.950,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.16534,1.2221629619598389,3.07789,0.8207943709199456,2.6216150000000003,1.4930671854599729,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.031,1.79908,1.14733,Destabilizing,-0.1079,Neutral,-0.03514,0.07773,Neutral,66.1,,False,66.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.3,T,-0.3445,0.0422,-22.2332,-6.36434781999315,0.8707352358193703,Pathogenic,0.9894,pathogenic,-4.31,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N247V,NP_000537:p.Asn247Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.70911,1.655245304107666,4.52993,0.5779024834039526,3.11952,1.1435062417019761,Uncertain,Neutral,Uncertain,Destabilizing,Neutral,False,0.031,0.27388,,Uncertain,-0.06389,Neutral,-0.03259,,Uncertain,66.1,,False,66.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,T,-0.3686,0.0422,-22.2332,-7.87845834414539,0.868936198158043,Pathogenic,0.9937,pathogenic,-4.584,available,https://doi.org/10.1101/2022.10.22.513328 +N247W,NP_000537:p.Asn247Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.79987,1.1425399780273438,0.92075,-0.1337514585490251,1.3603100000000001,0.8330592707254875,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.031,2.53384,,Uncertain,0.68238,Neutral,-0.43498,,Uncertain,66.1,,False,66.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,T,-0.3872,0.0422,-22.2332,-7.61411973536705,0.8707789323058057,Pathogenic,0.9986,pathogenic,-4.79,available,https://doi.org/10.1101/2022.10.22.513328 +N247Y,NP_000537:p.Asn247Tyr,"hg38,17:g.7674224T>A",,,0.959,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.47875,1.1434276103973389,0.53163,0.2527732463128851,0.50519,0.36576162315644256,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.031,3.20718,0.08049,Uncertain,-0.89571,Neutral,-0.58603,-0.16168,Neutral,66.1,,False,66.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.3,T,-0.3657,0.0422,-22.2332,-7.61411973536705,0.867777704798494,Pathogenic,0.9639,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248A,NP_000537:p.Arg248Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.47236,-0.0266227722167968,0.27925,0.5796286322558322,0.375805,0.5259943161279161,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,1.30974,,Uncertain,0.32613,Neutral,-0.01519,,Uncertain,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.4024,0.0804,-22.2302,-7.78923574105153,0.8364974474240843,Pathogenic,0.9999,pathogenic,-4.625,available,https://doi.org/10.1101/2022.10.22.513328 +R248C,NP_000537:p.Arg248Cys,"hg38,17:g.7674219_7674221delinsGCA",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.18811,-0.7160179615020752,0.17381,1.016040753276246,0.18096,0.602075376638123,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,1.37136,2.16424,Destabilizing,-0.20003,Neutral,-0.15797,0.07621,Neutral,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.4113,0.0804,-22.2302,-7.78923574105153,0.8472037373961158,Pathogenic,0.9978,pathogenic,-4.448,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248D,NP_000537:p.Arg248Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.70212,-0.1450506448745727,-0.42007,0.2630512818692843,-0.561095,-0.21953435906535784,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,1.57844,,Uncertain,0.92274,Neutral,-0.28805,,Uncertain,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.4935,0.0804,-22.2302,-7.05601679688749,0.8167720682091408,Pathogenic,0.9996,pathogenic,-4.866,available,https://doi.org/10.1101/2022.10.22.513328 +R248E,NP_000537:p.Arg248Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.18316,0.0118112564086914,-0.08844,0.2504098292051138,0.04735999999999999,0.2167849146025569,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,1.57086,,Uncertain,0.45545,Neutral,-0.64184,,Uncertain,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.4387,0.0804,-22.2302,-7.05601679688749,0.8478851283001736,Pathogenic,0.9988,pathogenic,-4.812,available,https://doi.org/10.1101/2022.10.22.513328 +R248F,NP_000537:p.Arg248Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.33035,-0.0767998695373535,-0.92823,0.0306548063388462,-0.29894,0.1805024031694231,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,0.86244,,Uncertain,0.29193,Neutral,-1.01015,,Uncertain,87.5,,True,87.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.76,T,-0.4346,0.0804,-22.2302,-7.37527863068139,0.7941719867485127,Pathogenic,0.9999,pathogenic,-4.808,available,https://doi.org/10.1101/2022.10.22.513328 +R248G,NP_000537:p.Arg248Gly,"hg19,17:g.7577539G>C, hg19,17:g.7674221G>C, hg38,17:g.7674221G>C",,,0.932,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376652,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.91529,-0.9312673807144164,-0.61735,0.8581147006771067,-0.76632,-0.028587649661446668,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,1.0314,1.7442,Destabilizing,0.32964,Neutral,0.00701,-0.06609,Neutral,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.37,0.0804,-8.9424,-7.78923574105153,0.1175684121165306,Benign,0.9985,pathogenic,-4.395,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248H,NP_000537:p.Arg248His,"hg19,17:g.7577537_7577538delinsGT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.40949,-0.3696962594985962,-0.6949,-0.0141911281500545,-0.14270499999999997,0.19764943592497275,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,0.49476,1.97784,Uncertain,-0.55284,Neutral,-0.25039,0.04215,Neutral,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.3722,0.0804,-22.2302,-7.37527863068139,0.8180696750264247,Pathogenic,0.996,pathogenic,-4.376,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248I,NP_000537:p.Arg248Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.659,0.8195136785507202,4.24014,0.4225319130798238,3.44957,1.5407659565399119,Uncertain,Uncertain,Neutral,Destabilizing,Neutral,False,0.03,0.9889,,Uncertain,-0.04058,Neutral,-0.49201,,Uncertain,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.4318,0.0804,-22.2302,-7.78923574105153,0.8260364464789325,Pathogenic,0.9999,pathogenic,-4.688,available,https://doi.org/10.1101/2022.10.22.513328 +R248K,NP_000537:p.Arg248Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01955,-0.1406881809234619,-0.42585,0.2101540543333441,-0.2227,0.09530202716667205,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,0.7402,,Uncertain,0.01249,Neutral,-0.22084,,Uncertain,87.5,,True,87.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.76,T,-0.2927,0.0804,-22.2302,-4.31455422016133,0.3809116699357284,Uncertain,0.995,pathogenic,-3.986,available,https://doi.org/10.1101/2022.10.22.513328 +R248L,NP_000537:p.Arg248Leu,"hg19,17:g.7577537_7577538delinsAA, hg19,17:g.7577538C>A, hg19,17:g.7577538_7577539delinsAA, hg19,17:g.7674220C>A, hg38,17:g.7674219_7674220delinsAA, hg38,17:g.7674220C>A",,,0.960,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",230253,Pathogenic,3,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.04136,0.0477396249771118,-0.2483,-0.1066529245202385,-0.10346999999999999,-0.03264646226011925,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,1.37492,1.83064,Destabilizing,-0.2804,Neutral,-0.50141,0.00517,Neutral,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.4049,0.0804,-22.2302,-7.78923574105153,0.8641967556697767,Pathogenic,0.999,pathogenic,-4.496,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248M,NP_000537:p.Arg248Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.20678,-0.0955810546875,0.43503,0.2469860493105541,0.320905,0.22688302465527704,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,1.0569,,Uncertain,-0.64109,Neutral,-0.89593,,Uncertain,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.3707,0.0804,-22.2302,-7.78923574105153,0.8510988626688266,Pathogenic,1.0,pathogenic,-4.688,available,https://doi.org/10.1101/2022.10.22.513328 +R248N,NP_000537:p.Arg248Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.39398,-0.5895881652832031,-0.84762,0.2167657600427808,-0.6208,-0.0886071199786096,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,0.50394,,Uncertain,-0.53945,Neutral,-0.09738,,Uncertain,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.4173,0.0804,-22.2302,-7.05601679688749,0.8349916134350399,Pathogenic,0.9997,pathogenic,-4.684,available,https://doi.org/10.1101/2022.10.22.513328 +R248P,NP_000537:p.Arg248Pro,"hg19,17:g.7577537_7577538delinsAG, hg19,17:g.7577538C>G, hg19,17:g.7674220C>G, hg38,17:g.7674220C>G",,,0.965,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",237954,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.30068,1.3832502365112305,6.60612,3.2240720166115344,4.9534,3.2623760083057673,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.03,1.20912,2.1427,Destabilizing,0.3284,Neutral,-0.22947,-0.15868,Neutral,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.4716,0.0804,-7.9424,-4.8646206736246,0.6995874531231092,Pathogenic,0.9994,pathogenic,-4.511,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248Q,NP_000537:p.Arg248Gln,"hg19,17:g.7577537_7577538delinsTT, hg19,17:g.7577538C>T, hg19,17:g.7674219_7674220delinsTT, hg19,17:g.7674220C>T, hg38,17:g.7674219_7674220delinsTT, hg38,17:g.7674220C>T",,1.19296627087e-05,0.934,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12356,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.1001,-0.1728384494781494,0.01735,0.3917375454763855,0.058725,0.24591877273819274,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,0.89584,1.44799,Uncertain,-0.49203,Neutral,-0.58103,-0.13805,Neutral,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.3093,0.0804,-8.9424,-2.41390063355383,0.0051465720633868,Benign,0.9963,pathogenic,-3.865,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248S,NP_000537:p.Arg248Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.1592,-0.0588077306747436,0.30476,0.6332408782153955,0.07277999999999998,0.23702043910769777,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,1.52236,,Uncertain,-0.43714,Neutral,-0.24338,,Uncertain,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.403,0.0804,-22.2302,-7.78923574105153,0.8318611716201587,Pathogenic,0.9998,pathogenic,-4.566,available,https://doi.org/10.1101/2022.10.22.513328 +R248T,NP_000537:p.Arg248Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.57759,0.5356224179267883,0.05068,0.6068341818081138,0.31413500000000005,0.5922120909040569,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,1.44684,,Uncertain,0.65495,Neutral,-0.27812,,Uncertain,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.4073,0.0804,-22.2302,-7.78923574105153,0.8519966515306652,Pathogenic,0.9999,pathogenic,-4.676,available,https://doi.org/10.1101/2022.10.22.513328 +R248V,NP_000537:p.Arg248Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.73013,0.7355020046234131,4.00578,0.5095438798824836,3.367955,1.6198369399412418,Uncertain,Uncertain,Neutral,Destabilizing,Neutral,False,0.03,1.10698,,Uncertain,0.4031,Neutral,-0.25574,,Uncertain,87.5,,True,87.5,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,96.76,T,-0.4189,0.0804,-22.2302,-7.78923574105153,0.7953089369008473,Pathogenic,0.9999,pathogenic,-4.752,available,https://doi.org/10.1101/2022.10.22.513328 +R248W,NP_000537:p.Arg248Trp,"hg19,17:g.7577539G>A, hg19,17:g.7577539_7577540delinsAA, hg19,17:g.7674221G>A, hg19,17:g.7674221_7674222delinsAA, hg38,17:g.7674221G>A, hg38,17:g.7674221_7674222delinsAA",,3.9765226105e-06,0.927,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","437017, 12347","Likely pathogenic, Pathogenic","1, 3",Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.59659,-0.064141571521759,-0.20204,-0.384939131860052,0.19727499999999998,0.10582543406997397,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,0.93696,1.00796,Uncertain,-0.41403,Neutral,-0.85652,-0.32852,Neutral,87.5,,True,87.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.76,T,-0.4202,0.0804,-22.2302,-2.72930677208217,0.816271765854447,Pathogenic,0.9968,pathogenic,-4.533,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R248Y,NP_000537:p.Arg248Tyr,,,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.55976,-0.0205507278442382,-0.80238,0.0878829516133189,-0.12130999999999997,0.3238214758066595,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.03,0.81814,1.86265,Uncertain,-0.12293,Neutral,-0.76787,-0.23402,Neutral,87.5,,True,87.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.76,T,-0.4239,0.0804,-22.2302,-7.37527863068139,0.7531925884834364,Pathogenic,0.9993,pathogenic,-4.521,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249A,NP_000537:p.Arg249Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.14923,0.8631124496459961,2.00374,1.366487078825395,2.076485,1.7578585394126978,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.07,1.08328,,,-0.01227,Neutral,0.13428,,,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.4024,0.0804,-22.2302,-5.60825935947658,0.7817496799181076,Pathogenic,0.9991,pathogenic,-4.642,available,https://doi.org/10.1101/2022.10.22.513328 +R249C,NP_000537:p.Arg249Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.50285,0.1487900018692016,1.17075,1.6054877376982886,1.3368,1.5541688688491444,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,1.28706,,,-0.01201,Neutral,-0.01701,,,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.4113,0.0804,-22.2302,-6.93003648537252,0.841513490531449,Pathogenic,0.9866,pathogenic,-4.4,available,https://doi.org/10.1101/2022.10.22.513328 +R249D,NP_000537:p.Arg249Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.99013,1.3604631423950195,2.16497,2.2836589729087,2.57755,2.63689448645435,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.07,1.22336,,,-0.0307,Neutral,-0.01487,,,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.4935,0.0804,-22.2302,-7.34865171184662,0.8659884233402495,Pathogenic,0.9995,pathogenic,-4.814,available,https://doi.org/10.1101/2022.10.22.513328 +R249E,NP_000537:p.Arg249Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.91536,0.730614185333252,2.51463,1.9052535128991344,2.714995,2.4103067564495673,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.07,1.4381,,,-0.03986,Neutral,-0.04095,,,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.3709,0.0804,-8.9424,-4.73127044247835,0.260375439748877,Benign,0.9969,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +R249F,NP_000537:p.Arg249Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.65919,0.5756414532661438,1.59966,-0.1589063165330079,1.629425,0.750141841733496,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-0.1191,,,0.02239,Neutral,-0.08559,,,22.8,P,True,22.8,,uncertain,neutral,neutral,UP,destabilizing,neutral,False,neutral,neutral,97.44,-,-0.4346,0.0804,-22.2302,-7.87688531520774,0.8468662335493051,Pathogenic,0.9993,pathogenic,-4.778,available,https://doi.org/10.1101/2022.10.22.513328 +R249G,NP_000537:p.Arg249Gly,"hg19,17:g.7577534_7577536delinsACC, hg19,17:g.7577536T>C, hg19,17:g.7674218T>C, hg38,17:g.7674216_7674218delinsACC, hg38,17:g.7674218T>C",,,0.888,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376654,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.5496,1.5446698665618896,3.45442,2.705273275371983,3.50201,3.1274366376859914,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.07,1.08656,0.3471,Uncertain,-0.01157,Neutral,0.02983,0.01504,Neutral,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.4378,0.0804,-22.2302,-7.87688531520774,0.8326299114228841,Pathogenic,0.9979,pathogenic,-4.386,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249H,NP_000537:p.Arg249His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.77064,0.2232182025909423,0.02109,0.798120080574668,1.3958650000000001,1.784380040287334,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.07,-0.83078,,,0.01808,Neutral,0.0266,,,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.3722,0.0804,-22.2302,-7.87688531520774,0.868839910325411,Pathogenic,0.9648,pathogenic,-4.378,available,https://doi.org/10.1101/2022.10.22.513328 +R249I,NP_000537:p.Arg249Ile,"hg19,17:g.7577534_7577535delinsAA, hg38,17:g.7674216_7674217delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.53691,0.2674827575683594,-0.53537,-0.0751984907765268,0.0007699999999999929,0.2308557546117366,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.49874,0.41212,Neutral,-0.00508,Neutral,-0.13086,-0.00633,Neutral,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.4318,0.0804,-22.2302,-7.87688531520774,0.8602560283999294,Pathogenic,0.9981,pathogenic,-4.67,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249K,NP_000537:p.Arg249Lys,"hg19,17:g.7577535C>T, hg19,17:g.7674217C>T, hg38,17:g.7674217C>T",,,0.893,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142241,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.5872,0.1027237176895141,1.5449,1.438832422042039,1.56605,1.5130162110210195,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.3073,0.35035,Neutral,0.00899,Neutral,-0.08714,-0.08633,Neutral,22.8,P,True,22.8,,uncertain,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.44,-,-0.2927,0.0804,-22.2302,-2.22538311817255,0.0805817081852227,Benign,0.9066,pathogenic,-3.778,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249L,NP_000537:p.Arg249Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.07326,0.2464501857757568,-1.67789,-0.1951655064617352,-0.302315,0.4390472467691324,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.84676,,,-0.00612,Neutral,-0.12174,,,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.4049,0.0804,-22.2302,-7.87688531520774,0.8633589060423119,Pathogenic,0.9922,pathogenic,-4.493,available,https://doi.org/10.1101/2022.10.22.513328 +R249M,NP_000537:p.Arg249Met,"hg19,17:g.7577535C>A, hg19,17:g.7674217C>A, hg38,17:g.7674217C>A",,,0.911,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376653,Conflicting classifications of pathogenicity,1,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.861,0.4591017365455627,0.94898,0.2967412465446495,0.90499,0.5788706232723247,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.27342,0.36325,Neutral,0.01889,Neutral,-0.00507,-0.00449,Neutral,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.3707,0.0804,-22.2302,-7.87688531520774,0.6325337450572295,Uncertain,0.9991,pathogenic,-4.395,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249N,NP_000537:p.Arg249Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.31512,0.5472922325134277,1.77857,1.3278652745393926,2.046845,1.8214926372696962,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.07,0.69946,,,0.00515,Neutral,-0.04119,,,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.4173,0.0804,-22.2302,-7.34865171184662,0.7433369253541168,Pathogenic,0.9988,pathogenic,-4.51,available,https://doi.org/10.1101/2022.10.22.513328 +R249P,NP_000537:p.Arg249Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.34708,1.838445425033569,6.7381,4.704356634921751,6.042590000000001,5.025718317460876,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.07,1.34898,,,0.01949,Neutral,-0.00113,,,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.5445,0.0804,-22.2302,-7.87688531520774,0.8243009654134557,Pathogenic,0.999,pathogenic,-4.678,available,https://doi.org/10.1101/2022.10.22.513328 +R249Q,NP_000537:p.Arg249Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.3243,0.433994710445404,1.47585,1.335023524595393,1.9000750000000002,1.8296617622976965,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.07,0.14776,,,0.00484,Neutral,-0.08327,,,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.3771,0.0804,-22.2302,-7.1933300927982,0.2796066225798573,Benign,0.9675,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328 +R249S,NP_000537:p.Arg249Ser,"hg19,17:g.7577534C>A, hg19,17:g.7577534C>G, hg19,17:g.7674216C>A, hg19,17:g.7674216C>G, hg38,17:g.7674216C>A, hg38,17:g.7674216C>G",,,0.769,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","406598, 12352","Conflicting classifications of pathogenicity, Pathogenic/Likely pathogenic","1, 2",Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.54714,1.0068548917770386,1.87177,2.109973343273821,2.209455,2.3285566716369104,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.07,1.2316,0.40736,Uncertain,-0.01025,Neutral,0.00339,-0.05045,Neutral,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.3301,0.0804,-7.9424,-3.73633473777127,0.5292616088672764,Uncertain,0.9995,pathogenic,-4.344,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249T,NP_000537:p.Arg249Thr,"hg19,17:g.7577535C>G, hg19,17:g.7674217C>G, hg38,17:g.7674217C>G",,,0.921,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376015,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.61843,0.7919253706932068,1.26463,1.2974825562661207,1.44153,1.4579562781330604,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,1.15698,0.47082,Uncertain,-0.01161,Neutral,0.00739,-0.0576,Neutral,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.4073,0.0804,-22.2302,-6.93003648537252,0.8513918186508777,Pathogenic,0.9994,pathogenic,-4.546,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249V,NP_000537:p.Arg249Val,"hg38,17:g.7674217_7674218delinsAC",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.36853,0.2158169746398925,-0.09388,0.0769084969721806,0.137325,0.22271924848609032,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,0.73022,0.50611,Neutral,-0.01022,Neutral,-0.02584,0.09112,Neutral,22.8,P,True,22.8,,uncertain,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.44,-,-0.4189,0.0804,-22.2302,-7.87688531520774,0.8545689448061059,Pathogenic,0.9984,pathogenic,-4.643,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249W,NP_000537:p.Arg249Trp,"hg19,17:g.7577536T>A, hg19,17:g.7674218T>A, hg38,17:g.7674218T>A",,,0.846,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141881,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.06116,0.5230738520622253,1.05884,-0.1300841279635478,1.06,0.46553793601822613,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-1.49264,-0.39115,Uncertain,0.02422,Neutral,-0.11087,0.00731,Neutral,22.8,P,True,22.8,,uncertain,neutral,neutral,UP,destabilizing,neutral,False,neutral,neutral,97.44,-,-0.3523,0.0804,-8.9424,-7.87688531520774,0.8350813245641621,Pathogenic,0.9904,pathogenic,-4.469,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R249Y,NP_000537:p.Arg249Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.71086,0.4164959788322449,1.52789,0.0737946099734115,1.619375,0.8923273049867058,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.07,-1.14676,,,0.03232,Neutral,-0.08732,,,22.8,P,True,22.8,,uncertain,neutral,neutral,UP,destabilizing,neutral,False,neutral,neutral,97.44,-,-0.4239,0.0804,-22.2302,-7.87688531520774,0.8394722016292288,Pathogenic,0.9966,pathogenic,-4.658,available,https://doi.org/10.1101/2022.10.22.513328 +P250A,NP_000537:p.Pro250Ala,"hg19,17:g.7577533G>C, hg38,17:g.7674215G>C",,,0.892,"COSMIC,ClinVar,saturation_mutlist",1759142,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.71206,0.322792112827301,0.81054,-0.3994775830785491,1.2612999999999999,0.6562912084607254,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.184,0.5943,-0.0117,Neutral,0.0,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.88,-,-0.243,0.0957,-7.3604,-4.08421037088883,0.0001692279423573,Benign,0.4876,ambiguous,-3.43,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250C,NP_000537:p.Pro250Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.09842,0.3351983428001404,1.67823,0.4196859464910191,1.888325,1.2590529732455096,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.184,0.59526,,Uncertain,-0.02375,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.88,-,-0.3515,0.0957,-22.2332,-6.36482132236824,0.5202731322287036,Uncertain,0.98,pathogenic,-4.39,available,https://doi.org/10.1101/2022.10.22.513328 +P250D,NP_000537:p.Pro250Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.80572,0.4169952273368835,0.96224,-0.3910401398993013,1.88398,1.2073399300503493,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.184,0.70762,,Uncertain,-0.11953,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.88,-,-0.3774,0.0957,-22.2332,-6.79863953820232,0.7730113123811679,Pathogenic,0.9909,pathogenic,-4.449,available,https://doi.org/10.1101/2022.10.22.513328 +P250E,NP_000537:p.Pro250Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.48143,0.4926705956459045,1.29014,-0.5825299898974656,1.385785,0.4494500050512672,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.184,0.08258,,Uncertain,-0.10157,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.88,-,-0.3612,0.0957,-22.2332,-6.79863953820232,0.5805033766108295,Uncertain,0.9802,pathogenic,-4.222,available,https://doi.org/10.1101/2022.10.22.513328 +P250F,NP_000537:p.Pro250Phe,"hg19,17:g.7577532_7577533delinsAA, hg19,17:g.7674214_7674215delinsAA, hg38,17:g.7674214_7674215delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.49669,0.8045647740364075,1.46122,-1.0375122025326182,1.478955,0.22958889873369093,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.184,-0.11968,0.0234,Neutral,-0.09123,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.88,-,-0.38,0.0957,-22.2332,-7.87956709322664,0.841164041561647,Pathogenic,0.9966,pathogenic,-4.636,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250G,NP_000537:p.Pro250Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.50067,0.8264683485031128,1.96735,0.452942544120764,2.23401,1.476806272060382,Uncertain,Uncertain,Neutral,Uncertain,Neutral,True,0.184,0.5943,,Uncertain,-0.00053,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.88,-,-0.3332,0.0957,-22.2332,-6.52729321979455,0.448919611356421,Uncertain,0.8979,pathogenic,-4.174,available,https://doi.org/10.1101/2022.10.22.513328 +P250H,NP_000537:p.Pro250His,"hg19,17:g.7577532G>T, hg38,17:g.7674214G>T",,,0.941,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.51832,0.7457053661346436,1.64524,-0.8991493965503539,2.08178,0.8095853017248231,Uncertain,Uncertain,Neutral,Uncertain,Neutral,True,0.184,-0.01978,-0.11629,Neutral,-0.08949,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.88,-,-0.3576,0.0957,-22.2332,-7.87956709322664,0.8366416558029965,Pathogenic,0.9681,pathogenic,-4.323,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250I,NP_000537:p.Pro250Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.36374,0.7136017084121704,0.82483,-0.7598333101336258,1.094285,0.3019533449331871,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.184,0.62618,,Uncertain,-0.02637,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.88,-,-0.363,0.0957,-22.2332,-7.26553434087479,0.8657678820995451,Pathogenic,0.9914,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +P250K,NP_000537:p.Pro250Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.63906,0.7442495226860046,2.25034,-0.4740184230524169,1.9447,0.5825207884737915,Uncertain,Neutral,Neutral,Neutral,Neutral,True,0.184,-0.2195,,Uncertain,0.03783,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.88,-,-0.3529,0.0957,-22.2332,-6.06238074383924,0.6300274080261309,Uncertain,0.9833,pathogenic,-4.375,available,https://doi.org/10.1101/2022.10.22.513328 +P250L,NP_000537:p.Pro250Leu,"hg19,17:g.7577531_7577532delinsAA, hg19,17:g.7577532G>A, hg19,17:g.7674214G>A, hg38,17:g.7674213_7674214delinsAA, hg38,17:g.7674213_7674214delinsCA, hg38,17:g.7674214G>A",,,0.962,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",420136,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.77726,0.6273787021636963,0.93197,-1.184589041553491,1.354615,0.29633547922325454,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.184,-0.03872,-0.00784,Neutral,-0.08336,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.88,-,-0.2998,0.0957,-8.9453,-6.44255387688277,0.0529280836348316,Benign,0.9135,pathogenic,-3.873,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250M,NP_000537:p.Pro250Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.48793,0.6873701810836792,0.48469,-0.7725616887047554,0.98631,0.3576841556476223,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.184,-0.17164,,Uncertain,-0.09166,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.88,-,-0.3185,0.0957,-22.2332,-7.26553434087479,0.8161179912941776,Pathogenic,0.9774,pathogenic,-4.434,available,https://doi.org/10.1101/2022.10.22.513328 +P250N,NP_000537:p.Pro250Asn,"hg38,17:g.7674214_7674215delinsTT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.86323,0.7187784314155579,1.37245,-0.414983690338378,1.61784,0.7241231548308109,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.184,0.09008,-0.1609,Neutral,-0.00045,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.88,-,-0.3456,0.0957,-22.2332,-6.79863953820232,0.8187479292165503,Pathogenic,0.9671,pathogenic,-4.218,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250Q,NP_000537:p.Pro250Gln,"hg38,17:g.7674213_7674214delinsCT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.85226,0.6830937266349792,1.19864,-0.4125093257281426,1.52545,0.7198753371359288,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.184,0.00056,-0.07884,Neutral,-0.00575,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.88,-,-0.2795,0.0957,-8.9453,-4.85161353414926,0.2449128027232194,Benign,0.8981,pathogenic,-3.936,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250R,NP_000537:p.Pro250Arg,"hg19,17:g.7577532G>C, hg38,17:g.7674214G>C",,,0.963,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.68653,0.8333203792572021,2.76973,-0.6886985585658267,2.22813,0.4989157207170867,Uncertain,Neutral,Neutral,Uncertain,Neutral,True,0.184,-0.0559,-0.03233,Neutral,0.1093,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.88,-,-0.3887,0.0957,-22.2332,-6.63589747066615,0.2299835056498123,Benign,0.9472,pathogenic,-4.174,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250S,NP_000537:p.Pro250Ser,"hg19,17:g.7577533G>A, hg38,17:g.7674215G>A",,,0.939,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1316970,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.34839,0.467116117477417,1.45816,-0.1945702714894664,1.903275,1.0769098642552668,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.184,0.5968,0.04717,Neutral,-0.00898,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.88,-,-0.3185,0.0957,-22.2332,-5.55888467040599,0.3955166968068279,Uncertain,0.8246,pathogenic,-3.74,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250T,NP_000537:p.Pro250Thr,"hg19,17:g.7577533G>T, hg38,17:g.7674215G>T",,,0.949,"COSMIC,ClinVar,saturation_mutlist",1759140,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.82465,0.7232754230499268,1.37551,-0.3304852782973844,2.10008,1.2470823608513077,Uncertain,Uncertain,Neutral,Uncertain,Neutral,True,0.184,0.59572,0.06953,Neutral,-0.02694,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.88,-,-0.3307,0.0957,-22.2332,-6.36482132236824,0.5957661207463998,Uncertain,0.9194,pathogenic,-4.046,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P250V,NP_000537:p.Pro250Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.77088,0.7732404470443726,0.85544,-0.5195358028897135,1.3131599999999999,0.6256720985551433,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.184,0.59712,,Uncertain,-0.02626,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.88,-,-0.3184,0.0957,-22.2332,-7.26553434087479,0.8100130486626577,Pathogenic,0.9694,pathogenic,-4.339,available,https://doi.org/10.1101/2022.10.22.513328 +P250W,NP_000537:p.Pro250Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.19502,0.5345620512962341,1.93639,-1.5265997503631006,2.065705,0.3342101248184497,Uncertain,Uncertain,Neutral,Uncertain,Neutral,True,0.184,-0.37852,,Uncertain,-0.07419,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.88,-,-0.3925,0.0957,-22.2332,-7.87956709322664,0.8310535278588256,Pathogenic,0.9979,pathogenic,-4.71,available,https://doi.org/10.1101/2022.10.22.513328 +P250Y,NP_000537:p.Pro250Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.3826,0.6536988019943237,1.40816,-0.942854078047642,1.39538,0.21987296097617903,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.184,-0.15868,,Uncertain,0.11151,Neutral,,,Uncertain,37.1,,True,37.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.88,-,-0.3809,0.0957,-22.2332,-7.87956709322664,0.8525930830501938,Pathogenic,0.9949,pathogenic,-4.608,available,https://doi.org/10.1101/2022.10.22.513328 +I251A,NP_000537:p.Ile251Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.81986,2.261911392211914,3.37381,3.291383066798196,3.596835,3.5556215333990977,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.33,E,-0.4208,0.0592,-22.2332,-5.12691728192533,0.8594171368121056,Pathogenic,0.9894,pathogenic,-4.349,available,https://doi.org/10.1101/2022.10.22.513328 +I251C,NP_000537:p.Ile251Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.98455,1.4536479711532593,2.87109,3.2692479649160404,2.92782,3.1268989824580204,Uncertain,Uncertain,Uncertain,Uncertain,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.33,E,-0.4008,0.0592,-22.2332,-6.17822887715965,0.8702660809084544,Pathogenic,0.9972,pathogenic,-4.589,available,https://doi.org/10.1101/2022.10.22.513328 +I251D,NP_000537:p.Ile251Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.39563,3.339006423950196,5.46224,4.683223432711648,5.428935,5.039426716355823,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.33,E,-0.5449,0.0592,-22.2332,-7.82977005918113,0.8585892337927903,Pathogenic,0.9998,pathogenic,-4.912,available,https://doi.org/10.1101/2022.10.22.513328 +I251E,NP_000537:p.Ile251Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.87696,3.524952411651612,4.51259,4.1328774595441775,4.694775,4.504918729772089,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.33,E,-0.5258,0.0592,-22.2332,-7.82977005918113,0.870679803342197,Pathogenic,0.9995,pathogenic,-4.78,available,https://doi.org/10.1101/2022.10.22.513328 +I251F,NP_000537:p.Ile251Phe,"hg19,17:g.7577530T>A, hg19,17:g.7674212T>A, hg38,17:g.7674212T>A",,,0.962,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1518844,Likely pathogenic,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,7.13311,2.0957722663879395,-0.47857,1.874715350173056,3.32727,4.503912675086529,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.33,E,-0.3818,0.0592,-22.2332,-7.49805238025536,0.7534111953873852,Pathogenic,0.961,pathogenic,-4.265,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251G,NP_000537:p.Ile251Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.09411,3.1093337535858154,5.31769,5.428213017897041,5.2059,5.26116150894852,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.33,E,-0.5115,0.0592,-22.2332,-6.25203367962597,0.8689690696447354,Pathogenic,0.9989,pathogenic,-4.768,available,https://doi.org/10.1101/2022.10.22.513328 +I251H,NP_000537:p.Ile251His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.64202,3.440152645111084,2.18401,3.103149143483607,5.913015,6.372584571741804,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.33,E,-0.5114,0.0592,-22.2332,-7.56701182597447,0.8625239988462694,Pathogenic,0.9996,pathogenic,-4.687,available,https://doi.org/10.1101/2022.10.22.513328 +I251K,NP_000537:p.Ile251Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.7752,3.291553974151612,5.91293,5.168248626192457,5.3440650000000005,4.971724313096228,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.33,E,-0.5183,0.0592,-22.2332,-7.82977005918113,0.8635992466692368,Pathogenic,0.999,pathogenic,-4.786,available,https://doi.org/10.1101/2022.10.22.513328 +I251L,NP_000537:p.Ile251Leu,"hg19,17:g.7577530T>G, hg19,17:g.7674212T>G, hg38,17:g.7674212T>G",,,0.882,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182937,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.88059,0.7789092063903809,1.51497,0.7136037406693954,1.6977799999999998,1.2970968703346977,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.33,E,-0.306,0.0592,-22.2332,-3.66756218112283,0.2763584856273345,Benign,0.616,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251M,NP_000537:p.Ile251Met,"hg19,17:g.7577528G>C, hg38,17:g.7674210G>C",,,0.779,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",485046,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.18218,1.3964887857437134,1.94626,1.4472484468221265,1.0642200000000002,0.8147142234110633,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.33,E,-0.3117,0.0592,-22.2332,-3.71680218621941,0.707595092617297,Pathogenic,0.794,pathogenic,-3.876,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251N,NP_000537:p.Ile251Asn,"hg19,17:g.7577528_7577529delinsAT, hg19,17:g.7577529A>T, hg19,17:g.7674211A>T, hg38,17:g.7674210_7674211delinsAT, hg38,17:g.7674211A>T",,,0.927,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528254,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.63239,3.335686445236206,4.08163,3.1543451660886266,4.35701,3.8933675830443133,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.33,E,-0.4579,0.0592,-22.2332,-7.82977005918113,0.8695468387105436,Pathogenic,0.9968,pathogenic,-4.614,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251P,NP_000537:p.Ile251Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.89331,3.4759883880615234,4.8915,7.13027463118352,3.892405,5.01179231559176,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.33,E,-0.5649,0.0592,-22.2332,-7.82977005918113,0.8663255821895334,Pathogenic,0.997,pathogenic,-4.614,available,https://doi.org/10.1101/2022.10.22.513328 +I251Q,NP_000537:p.Ile251Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.76348,3.100224733352661,2.81156,3.116289956288548,3.2875199999999998,3.439884978144274,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.33,E,-0.4855,0.0592,-22.2332,-7.82977005918113,0.8680397080608632,Pathogenic,0.9991,pathogenic,-4.678,available,https://doi.org/10.1101/2022.10.22.513328 +I251R,NP_000537:p.Ile251Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.68415,3.4630661010742188,5.34592,4.166144753820448,7.015035,6.425147376910225,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.33,E,-0.5451,0.0592,-22.2332,-7.82977005918113,0.8585205005635097,Pathogenic,0.9986,pathogenic,-4.748,available,https://doi.org/10.1101/2022.10.22.513328 +I251S,NP_000537:p.Ile251Ser,"hg19,17:g.7577529A>C, hg19,17:g.7674211A>C, hg38,17:g.7674211A>C",,0.0,0.959,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182967,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.18672,3.038099527359009,3.9551,4.244466817925994,4.07091,4.215593408962997,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.33,E,-0.4614,0.0592,-22.2332,-6.17822887715965,0.8606346375179728,Pathogenic,0.992,pathogenic,-4.532,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251T,NP_000537:p.Ile251Thr,"hg19,17:g.7577529A>G, hg19,17:g.7674211A>G, hg38,17:g.7674211A>G",,,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",439320,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.42199,2.2997891902923584,2.27313,2.8927667270305126,2.34756,2.6573783635152566,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.33,E,-0.3053,0.0592,-7.9454,-4.31668056163262,0.264674153989896,Benign,0.9767,pathogenic,-3.796,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251V,NP_000537:p.Ile251Val,"hg19,17:g.7577530T>C, hg38,17:g.7674212T>C",,,0.856,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1759315,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.25972,0.3417603969573974,0.9432,0.974238197925958,1.1014599999999999,1.1169790989629789,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.33,E,-0.1983,0.0592,-8.9453,-2.99602757994519,0.0454933653739958,Benign,0.3679,ambiguous,-3.561,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I251W,NP_000537:p.Ile251Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,16.2705,2.705108642578125,0.9,3.094693894163628,8.585249999999998,9.682596947081812,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.33,E,-0.4707,0.0592,-22.2332,-7.56701182597447,0.8692122146259679,Pathogenic,0.9995,pathogenic,-4.824,available,https://doi.org/10.1101/2022.10.22.513328 +I251Y,NP_000537:p.Ile251Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.39754,2.8278234004974365,0.32721,2.9588486201531587,6.362375,7.678194310076579,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.28,,,,,,,,,0.3,,True,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.33,E,-0.4796,0.0592,-22.2332,-7.56701182597447,0.8702599703438643,Pathogenic,0.9979,pathogenic,-4.694,available,https://doi.org/10.1101/2022.10.22.513328 +L252A,NP_000537:p.Leu252Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.48082,1.5179286003112793,2.57449,2.6154033863757884,2.527655,2.548111693187894,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.19,E,-0.3924,0.295,-22.239,-5.32307947185743,0.2046868068149483,Benign,0.615,pathogenic,-3.95,available,https://doi.org/10.1101/2022.10.22.513328 +L252C,NP_000537:p.Leu252Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.28986,0.5139452219009399,2.43503,2.6684247060372424,2.362445,2.479142353018621,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.19,E,-0.3816,0.295,-22.239,-6.0620096481428,0.4233953826179751,Uncertain,0.6188,pathogenic,-4.089,available,https://doi.org/10.1101/2022.10.22.513328 +L252D,NP_000537:p.Leu252Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.68902,2.684090137481689,4.04592,3.349322366440976,3.86747,3.519171183220488,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.19,E,-0.5139,0.295,-22.239,-4.7962226105534,0.2743200689577354,Benign,0.9677,pathogenic,-4.043,available,https://doi.org/10.1101/2022.10.22.513328 +L252E,NP_000537:p.Leu252Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.23641,1.92900812625885,3.28163,2.7501847725908344,2.25902,1.993297386295417,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.19,E,-0.4819,0.295,-22.239,-4.43207227029161,0.0769919057840972,Benign,0.7475,pathogenic,-4.002,available,https://doi.org/10.1101/2022.10.22.513328 +L252F,NP_000537:p.Leu252Phe,"hg19,17:g.7577527G>A, hg38,17:g.7674209G>A",,,0.716,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1053765,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.9698,0.433897852897644,1.18333,0.5443618041969169,2.076565,1.7570809020984586,Uncertain,Uncertain,Neutral,Uncertain,Neutral,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.19,E,-0.3258,0.295,-22.239,-6.52101244700316,0.5923473637238145,Uncertain,0.3774,ambiguous,-3.91,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L252G,NP_000537:p.Leu252Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.00312,2.674400568008423,4.68231,4.08658362397716,4.342715,4.04485181198858,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.19,E,-0.4672,0.295,-22.239,-7.20169181714271,0.4922913796591854,Uncertain,0.9311,pathogenic,-4.297,available,https://doi.org/10.1101/2022.10.22.513328 +L252H,NP_000537:p.Leu252His,"hg19,17:g.7577526A>T, hg38,17:g.7674208A>T",,,0.914,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.89464,1.2970824241638184,2.61599,1.7766160658899175,3.755315,3.3356280329449586,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.19,E,-0.4347,0.295,-22.239,-6.10553946518275,0.3556995624617788,Uncertain,0.6136,pathogenic,-3.932,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L252I,NP_000537:p.Leu252Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.52205,-0.8056212663650513,-0.11054,0.4746549701885355,0.20575500000000002,0.49835248509426777,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.19,E,-0.1885,0.295,-6.9513,-0.565823379800516,0.0124868456697013,Benign,0.09,benign,-3.56,available,https://doi.org/10.1101/2022.10.22.513328 +L252K,NP_000537:p.Leu252Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.1767,1.17492938041687,2.53027,2.6148391767377808,2.353485,2.39576958836889,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.19,E,-0.481,0.295,-22.239,-5.12571930820422,0.0288233196274121,Benign,0.7311,pathogenic,-3.955,available,https://doi.org/10.1101/2022.10.22.513328 +L252M,NP_000537:p.Leu252Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.6831,0.4606062173843384,1.19796,0.9290206787307548,0.94053,0.8060603393653774,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.19,E,-0.2139,0.295,-7.3663,-2.34504626988143,0.0003431671763887,Benign,0.1395,benign,-3.506,available,https://doi.org/10.1101/2022.10.22.513328 +L252N,NP_000537:p.Leu252Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.12301,1.9548959732055664,2.72347,2.4308257395653188,2.92324,2.7769178697826593,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.19,E,-0.4602,0.295,-22.239,-4.34037649175041,0.3507042372828399,Uncertain,0.7671,pathogenic,-4.073,available,https://doi.org/10.1101/2022.10.22.513328 +L252P,NP_000537:p.Leu252Pro,"hg19,17:g.7577526A>G, hg19,17:g.7674208A>G, hg38,17:g.7674208A>G",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12350,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.92913,2.920544147491455,5.86735,5.692980454537548,5.3982399999999995,5.311055227268774,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.19,E,-0.4758,0.295,-22.239,-7.20169181714271,0.7946937304955756,Pathogenic,0.9967,pathogenic,-4.263,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L252Q,NP_000537:p.Leu252Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.36817,1.3751343488693235,2.0034,2.110425458854737,2.185785,2.239297729427369,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.19,E,-0.3453,0.295,-8.9511,-3.31028047262029,0.0104071968439334,Benign,0.3879,ambiguous,-3.607,available,https://doi.org/10.1101/2022.10.22.513328 +L252R,NP_000537:p.Leu252Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.04772,0.9779896140098572,2.40306,1.8558368370431533,2.22539,1.9517784185215765,Uncertain,Uncertain,Neutral,Uncertain,Neutral,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.19,E,-0.4047,0.295,-8.9511,-5.1513623328678,0.0520242855241158,Benign,0.5934,pathogenic,-3.996,available,https://doi.org/10.1101/2022.10.22.513328 +L252S,NP_000537:p.Leu252Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.63281,1.5794482231140137,3.42789,3.265575968164585,3.0303500000000003,2.9491929840822926,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.19,E,-0.3498,0.295,-7.9512,-4.27254861360225,0.0576205092532352,Benign,0.6428,pathogenic,-3.75,available,https://doi.org/10.1101/2022.10.22.513328 +L252T,NP_000537:p.Leu252Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.19137,0.6361098289489746,1.88265,2.14735436360713,2.53701,2.669362181803565,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.19,E,-0.3955,0.295,-22.239,-6.0620096481428,0.1699895125981999,Benign,0.4968,ambiguous,-4.024,available,https://doi.org/10.1101/2022.10.22.513328 +L252V,NP_000537:p.Leu252Val,"hg19,17:g.7577527G>C, hg38,17:g.7674209G>C",,,0.607,"ClinVar,saturation_mutlist",1759470,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.84076,-0.5130659341812134,0.27007,0.7659104628370319,1.055415,1.303335231418516,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.19,E,-0.2218,0.295,-6.3663,-0.444021344648924,3.825660962187732e-05,Benign,0.0882,benign,-3.461,available,https://doi.org/10.1101/2022.10.22.513328 +L252W,NP_000537:p.Leu252Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.79373,0.6204856038093567,1.17245,0.7747541600859398,1.98309,1.78424208004297,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.19,E,-0.425,0.295,-22.239,-6.52101244700316,0.8191540733618617,Pathogenic,0.6795,pathogenic,-4.402,available,https://doi.org/10.1101/2022.10.22.513328 +L252Y,NP_000537:p.Leu252Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.30595,0.4783147573471069,1.33571,1.0899561778245528,1.82083,1.6979530889122765,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.348,,,,,,,,,11.9,,True,11.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.19,E,-0.4179,0.295,-22.239,-5.50703915075823,0.2963794984336334,Benign,0.6985,pathogenic,-4.05,available,https://doi.org/10.1101/2022.10.22.513328 +T253A,NP_000537:p.Thr253Ala,"hg19,17:g.7577524T>C, hg19,17:g.7674206T>C, hg38,17:g.7674206T>C",,,0.854,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",827132,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.24265,0.6334055662155151,1.92449,0.8203246062987163,2.08357,1.531487303149358,Uncertain,Uncertain,Neutral,Uncertain,Neutral,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,DOWN,neutral,neutral,False,neutral,neutral,98.49,E,-0.1215,1.2519,-5.3663,-1.81376137317371,0.0002533113383874,Benign,0.5944,pathogenic,-3.478,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T253C,NP_000537:p.Thr253Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.88467,-0.1314935684204101,1.20918,0.8360819350022755,1.0469249999999999,0.8603759675011378,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,DOWN,neutral,neutral,False,neutral,neutral,98.49,E,-0.2434,1.2519,-22.239,-3.02168511213109,0.7445565640752505,Pathogenic,0.8623,pathogenic,-4.226,available,https://doi.org/10.1101/2022.10.22.513328 +T253D,NP_000537:p.Thr253Asp,"hg19,17:g.7577523_7577524delinsTC",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.28755,2.569297790527344,2.61327,2.373179506547634,1.95041,1.830364753273817,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,98.49,E,-0.3232,1.2519,-22.239,-6.06791127463505,0.8127573065977443,Pathogenic,0.9969,pathogenic,-4.599,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T253E,NP_000537:p.Thr253Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.95871,2.3756520748138428,1.85714,2.16354476880812,2.407925,2.56112738440406,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.49,E,-0.2985,1.2519,-22.239,-6.06791127463505,0.7965350861489514,Pathogenic,0.998,pathogenic,-4.6,available,https://doi.org/10.1101/2022.10.22.513328 +T253F,NP_000537:p.Thr253Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.13602,0.6638081073760986,0.11701,1.2359403301139478,2.626515,3.185980165056974,Uncertain,Uncertain,Neutral,Uncertain,Destabilizing,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.49,E,-0.3148,1.2519,-22.239,-6.20497469977993,0.6948569202578241,Pathogenic,0.9932,pathogenic,-4.328,available,https://doi.org/10.1101/2022.10.22.513328 +T253G,NP_000537:p.Thr253Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.86712,1.9298806190490725,4.54966,3.1615078458773005,4.20839,3.5143139229386504,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,DOWN,neutral,neutral,False,neutral,neutral,98.49,E,-0.2811,1.2519,-22.239,-6.43928617269642,0.8122163792423643,Pathogenic,0.9011,pathogenic,-4.421,available,https://doi.org/10.1101/2022.10.22.513328 +T253H,NP_000537:p.Thr253His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.45983,1.7251946926116943,0.93435,1.675579865896768,3.69709,4.067704932948384,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.49,E,-0.2951,1.2519,-22.239,-6.20497469977993,0.8589926606828056,Pathogenic,0.9883,pathogenic,-4.534,available,https://doi.org/10.1101/2022.10.22.513328 +T253I,NP_000537:p.Thr253Ile,"hg19,17:g.7577523G>A, hg19,17:g.7674205G>A, hg38,17:g.7674205G>A",,,0.790,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",837688,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.00437,-1.1213934421539309,-0.53095,-0.9750015630418528,-0.26329,-0.4853157815209264,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.49,E,-0.1243,1.2519,-0.8428,-1.96920395385682,0.0004182508112196,Benign,0.9634,pathogenic,-3.404,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T253K,NP_000537:p.Thr253Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.20386,1.9150354862213133,4.18639,4.808934292327398,4.695125,5.006397146163699,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.49,E,-0.2907,1.2519,-22.239,-6.43928617269642,0.8362232245901847,Pathogenic,0.9982,pathogenic,-4.542,available,https://doi.org/10.1101/2022.10.22.513328 +T253L,NP_000537:p.Thr253Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.34659,-0.2711573839187622,0.34014,-0.6814497914639772,-0.0032250000000000056,-0.5140198957319886,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.49,E,-0.2854,1.2519,-22.239,-2.73886578153278,0.0310664025945029,Benign,0.8156,pathogenic,-3.754,available,https://doi.org/10.1101/2022.10.22.513328 +T253M,NP_000537:p.Thr253Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.50727,0.2067632675170898,0.30102,0.5489606159946577,0.404145,0.5281153079973289,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.49,E,-0.1846,1.2519,-8.9511,-1.69755716348408,0.1947065243984903,Benign,0.7455,pathogenic,-3.724,available,https://doi.org/10.1101/2022.10.22.513328 +T253N,NP_000537:p.Thr253Asn,"hg19,17:g.7577523G>T, hg19,17:g.7674205G>T, hg38,17:g.7674205G>T",,,0.895,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",505571,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.82356,2.044353008270264,0.71837,1.1717696101366537,1.270965,1.497664805068327,Neutral,Neutral,Destabilizing,Neutral,Neutral,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,98.49,E,-0.1954,1.2519,-8.9511,-4.14012922934797,0.5558806593975456,Uncertain,0.9499,pathogenic,-4.141,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T253P,NP_000537:p.Thr253Pro,"hg19,17:g.7577524T>G, hg19,17:g.7674206T>G, hg38,17:g.7674206T>G",,,0.942,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3148769,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.6097,2.1780037879943848,4.69864,4.338381238552402,4.154170000000001,3.974040619276201,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,98.49,E,-0.3719,1.2519,-22.239,-6.43928617269642,0.833904233711422,Pathogenic,0.9882,pathogenic,-4.478,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T253Q,NP_000537:p.Thr253Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.51179,1.7809590101242063,0.65646,1.4042449063632856,2.0841250000000002,2.4580174531816428,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.49,E,-0.2727,1.2519,-22.239,-6.06791127463505,0.8521738256046161,Pathogenic,0.9914,pathogenic,-4.437,available,https://doi.org/10.1101/2022.10.22.513328 +T253R,NP_000537:p.Thr253Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.20086,1.890085220336914,4.09286,3.465816973779852,7.14686,6.833338486889926,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.49,E,-0.2935,1.2519,-22.239,-6.43928617269642,0.842563544816896,Pathogenic,0.9976,pathogenic,-4.608,available,https://doi.org/10.1101/2022.10.22.513328 +T253S,NP_000537:p.Thr253Ser,"hg19,17:g.7577523G>C, hg19,17:g.7577524T>A, hg38,17:g.7674205G>C, hg38,17:g.7674206T>A",,,"0.851, 0.854","cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.16403,1.0432231426239014,2.02721,1.8888331851231488,2.0956200000000003,2.0264315925615746,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.454,,,,,,,,,0.0,,True,0.0,,neutral,,,DOWN,neutral,neutral,False,neutral,neutral,98.49,E,-0.1713,1.2519,-22.239,-4.19430095203731,0.0191903966630435,Benign,0.6338,pathogenic,-4.095,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T253V,NP_000537:p.Thr253Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.51144,-1.0489325523376465,-1.21156,-0.9075188438362304,-0.35006,-0.1980394219181152,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.49,E,-0.1389,1.2519,-6.1439,-1.18688464182934,0.0245489013375776,Benign,0.8351,pathogenic,-3.52,available,https://doi.org/10.1101/2022.10.22.513328 +T253W,NP_000537:p.Thr253Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,17.15196,0.9164471626281738,2.43027,3.0837988627351525,9.791115,10.117879431367577,Uncertain,Destabilizing,Neutral,Destabilizing,Destabilizing,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.49,E,-0.3077,1.2519,-22.239,-6.20497469977993,0.8707838857818175,Pathogenic,0.9991,pathogenic,-4.712,available,https://doi.org/10.1101/2022.10.22.513328 +T253Y,NP_000537:p.Thr253Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.51235,0.8842584490776062,3.14252,2.6065388799284337,6.8274349999999995,6.559444439964217,Destabilizing,Uncertain,Neutral,Destabilizing,Destabilizing,True,0.454,,,,,,,,,0.0,,True,0.0,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.49,E,-0.3163,1.2519,-22.239,-6.20497469977993,0.8210330299668427,Pathogenic,0.9972,pathogenic,-4.578,available,https://doi.org/10.1101/2022.10.22.513328 +I254A,NP_000537:p.Ile254Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.73931,2.2063677310943604,3.08435,3.026284698377363,3.41183,3.3827973491886816,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.4224,0.0421,-22.2361,-5.67250387452748,0.7701140885175584,Pathogenic,0.9717,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328 +I254C,NP_000537:p.Ile254Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.92625,1.3042854070663452,2.61565,2.9907687201491666,2.77095,2.9585093600745833,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.4024,0.0421,-22.2361,-7.00135748934014,0.8498705233904261,Pathogenic,0.987,pathogenic,-4.446,available,https://doi.org/10.1101/2022.10.22.513328 +I254D,NP_000537:p.Ile254Asp,"hg19,17:g.7577520_7577521delinsTC, hg19,17:g.7674202_7674203delinsTC, hg38,17:g.7674202_7674203delinsTC",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.2965,2.6710495948791504,3.94694,4.014832814552001,4.12172,4.155666407276001,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.5464,0.0421,-22.2361,-7.91994321044374,0.8702608441690488,Pathogenic,0.9995,pathogenic,-4.818,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254E,NP_000537:p.Ile254Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.94044,2.610334873199463,4.74116,3.5335686449171098,4.3408,3.7370043224585547,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.5274,0.0421,-22.2361,-7.91994321044374,0.8012481145341709,Pathogenic,0.9982,pathogenic,-4.658,available,https://doi.org/10.1101/2022.10.22.513328 +I254F,NP_000537:p.Ile254Phe,"hg19,17:g.7577521T>A, hg19,17:g.7674203T>A, hg38,17:g.7674203T>A",,,0.942,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.2517,1.350000500679016,0.42279,1.463134003451076,2.337245,2.857417001725538,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.3834,0.0421,-22.2361,-7.91994321044374,0.8708591134846212,Pathogenic,0.935,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254G,NP_000537:p.Ile254Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.95223,2.659519910812378,4.8102,4.942623818052415,4.881215,4.947426909026207,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.5131,0.0421,-22.2361,-7.91994321044374,0.8702426006797316,Pathogenic,0.9979,pathogenic,-4.752,available,https://doi.org/10.1101/2022.10.22.513328 +I254H,NP_000537:p.Ile254His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.8288,2.394153118133545,1.78707,2.557534338485316,4.3079350000000005,4.693167169242658,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.513,0.0421,-22.2361,-7.91994321044374,0.86878964668506,Pathogenic,0.9981,pathogenic,-4.634,available,https://doi.org/10.1101/2022.10.22.513328 +I254K,NP_000537:p.Ile254Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.77295,2.7479467391967773,5.7881,3.677834695428963,4.780525,3.7253923477144815,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.41,E,-0.5199,0.0421,-22.2361,-7.91994321044374,0.8704077092948044,Pathogenic,0.9979,pathogenic,-4.681,available,https://doi.org/10.1101/2022.10.22.513328 +I254L,NP_000537:p.Ile254Leu,"hg19,17:g.7577521T>G, hg38,17:g.7674203T>G",,,0.871,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.23257,0.8091720342636108,1.02891,0.5250358771522403,0.39817,0.14623293857612016,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.41,E,-0.2398,0.0421,-8.9482,-4.22488625076884,0.1023629050292371,Benign,0.6108,pathogenic,-3.714,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254M,NP_000537:p.Ile254Met,"hg19,17:g.7577519G>C, hg38,17:g.7674201G>C",,,0.877,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2135554,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.43876,1.3625538349151611,1.14626,1.352396927141298,0.79251,0.8955784635706491,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.41,E,-0.3133,0.0421,-22.2361,-4.75314403238212,0.869049203570615,Pathogenic,0.6518,pathogenic,-4.174,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254N,NP_000537:p.Ile254Asn,"hg19,17:g.7577519_7577520delinsAT, hg19,17:g.7577520A>T, hg19,17:g.7674202A>T, hg38,17:g.7674201_7674202delinsAT, hg38,17:g.7674202A>T",,,0.962,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2817584, 856299","Pathogenic, Pathogenic","1, 3",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.05511,2.612621068954468,2.74864,2.858390985323055,2.901875,2.9567504926615276,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.4595,0.0421,-22.2361,-7.91994321044374,0.8610421676740224,Pathogenic,0.9911,pathogenic,-4.618,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254P,NP_000537:p.Ile254Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.61623,2.791830539703369,3.43435,7.058985062530838,4.02529,5.837607531265419,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.5665,0.0421,-22.2361,-7.91994321044374,0.8642001975602676,Pathogenic,0.9989,pathogenic,-4.701,available,https://doi.org/10.1101/2022.10.22.513328 +I254Q,NP_000537:p.Ile254Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.64359,2.692418336868286,3.08435,2.721882268009928,2.86397,2.682736134004964,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.4871,0.0421,-22.2361,-7.91994321044374,0.8706040152119583,Pathogenic,0.9976,pathogenic,-4.595,available,https://doi.org/10.1101/2022.10.22.513328 +I254R,NP_000537:p.Ile254Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.08744,2.759360074996948,3.1949,2.653075791402056,3.14117,2.870257895701028,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.5467,0.0421,-22.2361,-7.91994321044374,0.8657925023713351,Pathogenic,0.9958,pathogenic,-4.64,available,https://doi.org/10.1101/2022.10.22.513328 +I254S,NP_000537:p.Ile254Ser,"hg19,17:g.7577520A>C, hg19,17:g.7674202A>C, hg38,17:g.7674202A>C",,0.0,0.953,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",659457,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.70541,2.52661681175232,3.58946,3.9285136553327136,4.147435,4.316961827666357,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.463,0.0421,-22.2361,-7.00135748934014,0.8406404354528518,Pathogenic,0.9848,pathogenic,-4.478,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254T,NP_000537:p.Ile254Thr,"hg19,17:g.7577520A>G, hg38,17:g.7674202A>G",,,0.954,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1759844,Pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.40827,2.163661003112793,2.2017,2.583680830060272,2.8049850000000003,2.995975415030136,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.3798,0.0421,-22.2361,-7.00135748934014,0.8677703314347418,Pathogenic,0.9725,pathogenic,-4.188,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254V,NP_000537:p.Ile254Val,"hg19,17:g.7577521T>C, hg38,17:g.7674203T>C",,1.5906090442e-05,0.780,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406605,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42896,0.6039128303527832,0.38946,0.6489813528309357,0.90921,1.0389706764154678,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.41,E,-0.1999,0.0421,-8.9482,-2.63502144052448,0.0254825571047142,Benign,0.1871,benign,-3.418,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I254W,NP_000537:p.Ile254Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.50961,1.832157015800476,1.87585,2.2050952589895747,4.69273,4.8573526294947875,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.4723,0.0421,-22.2361,-7.91994321044374,0.8693088227163428,Pathogenic,0.9976,pathogenic,-4.746,available,https://doi.org/10.1101/2022.10.22.513328 +I254Y,NP_000537:p.Ile254Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.33777,1.747884750366211,0.92177,2.286005583191629,3.1297699999999997,3.8118877915958143,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,True,0.514,,,,,,,,,3.8,,True,3.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.41,E,-0.4811,0.0421,-22.2361,-7.91994321044374,0.8639202665605441,Pathogenic,0.9919,pathogenic,-4.655,available,https://doi.org/10.1101/2022.10.22.513328 +I255A,NP_000537:p.Ile255Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.75749,3.0549230575561523,4.22619,3.48196141700463,4.49184,4.119725708502315,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.58,E,-0.291,1.4703,-22.239,-6.43911129997014,0.8308949374677067,Pathogenic,0.9732,pathogenic,-4.142,available,https://doi.org/10.1101/2022.10.22.513328 +I255C,NP_000537:p.Ile255Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.8896,1.9816950559616089,3.50816,3.304022235990774,3.69888,3.596811117995387,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.58,E,-0.271,1.4703,-22.239,-6.43911129997014,0.7937256395179739,Pathogenic,0.9727,pathogenic,-4.267,available,https://doi.org/10.1101/2022.10.22.513328 +I255D,NP_000537:p.Ile255Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.82985,4.656275749206543,4.66395,4.535615343773351,4.7469,4.682732671886676,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.58,E,-0.4151,1.4703,-22.239,-6.43911129997014,0.844646006177901,Pathogenic,0.9998,pathogenic,-4.742,available,https://doi.org/10.1101/2022.10.22.513328 +I255E,NP_000537:p.Ile255Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.25202,4.167566776275635,3.77823,4.139523697185035,3.5151250000000003,3.6957718485925173,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.58,E,-0.396,1.4703,-22.239,-6.43911129997014,0.8060967361543939,Pathogenic,0.9992,pathogenic,-4.748,available,https://doi.org/10.1101/2022.10.22.513328 +I255F,NP_000537:p.Ile255Phe,"hg19,17:g.7577518T>A, hg19,17:g.7674200T>A, hg38,17:g.7674200T>A",,,0.785,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376621,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.27642,1.6284583806991575,2.03639,1.0631195205251869,3.156405,2.6697697602625934,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.58,E,-0.252,1.4703,-22.239,-3.51894571455168,0.2299504849217117,Benign,0.7283,pathogenic,-3.581,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I255G,NP_000537:p.Ile255Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.67626,4.271162509918213,6.61803,5.707361563462021,6.647145,6.191810781731011,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.58,E,-0.3817,1.4703,-22.239,-6.43911129997014,0.8599231051566617,Pathogenic,0.9982,pathogenic,-4.575,available,https://doi.org/10.1101/2022.10.22.513328 +I255H,NP_000537:p.Ile255His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.7294,3.203565835952759,3.28299,2.4327185829078988,3.506195,3.0810592914539496,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.58,E,-0.3816,1.4703,-22.239,-4.62349728709182,0.826189305818647,Pathogenic,0.9982,pathogenic,-4.588,available,https://doi.org/10.1101/2022.10.22.513328 +I255K,NP_000537:p.Ile255Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.84666,3.353132486343384,5.69524,5.473987245844709,5.27095,5.160323622922355,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.58,E,-0.3885,1.4703,-22.239,-6.43911129997014,0.8458772989612148,Pathogenic,0.9986,pathogenic,-4.695,available,https://doi.org/10.1101/2022.10.22.513328 +I255L,NP_000537:p.Ile255Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.0347,1.176499843597412,0.98776,0.9280191051196413,0.47653,0.44665955255982065,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.58,E,-0.0793,1.4703,-3.2508,-1.69880606760401,9.473667499229652e-06,Benign,0.2937,benign,-3.242,available,https://doi.org/10.1101/2022.10.22.513328 +I255M,NP_000537:p.Ile255Met,"hg38,17:g.7674198G>C",,,0.791,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.06384,1.6270536184310913,0.88469,1.5481258861573222,0.474265,0.805982943078661,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.58,E,-0.0997,1.4703,-6.1439,-1.79668142913908,0.0022981783374836,Benign,0.4549,ambiguous,-3.556,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I255N,NP_000537:p.Ile255Asn,"hg19,17:g.7577517A>T, hg19,17:g.7674199A>T, hg38,17:g.7674199A>T",,,0.928,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",232289,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.43412,4.131115436553955,3.67959,3.1073447849787663,3.556855,3.270732392489383,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.58,E,-0.3281,1.4703,-22.239,-6.43911129997014,0.8221242480018573,Pathogenic,0.9967,pathogenic,-4.556,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I255P,NP_000537:p.Ile255Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.28395,3.97371506690979,5.67585,7.333099082195931,5.4799,6.308524541097965,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.58,E,-0.4351,1.4703,-22.239,-6.43911129997014,0.7576963461620445,Pathogenic,0.9988,pathogenic,-4.62,available,https://doi.org/10.1101/2022.10.22.513328 +I255Q,NP_000537:p.Ile255Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.99181,3.520260572433472,2.89082,3.138813743982155,3.4413150000000003,3.5653118719910775,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.58,E,-0.3557,1.4703,-22.239,-6.43911129997014,0.7913340875249034,Pathogenic,0.9979,pathogenic,-4.591,available,https://doi.org/10.1101/2022.10.22.513328 +I255R,NP_000537:p.Ile255Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.10524,3.350290060043335,4.08469,4.183893107967029,6.594965,6.644566553983514,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.58,E,-0.4153,1.4703,-22.239,-6.43911129997014,0.8526216881455042,Pathogenic,0.9972,pathogenic,-4.732,available,https://doi.org/10.1101/2022.10.22.513328 +I255S,NP_000537:p.Ile255Ser,"hg19,17:g.7577517A>C, hg19,17:g.7674199A>C, hg38,17:g.7674199A>C",,,0.943,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376622,Uncertain significance,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.8607,3.728898286819458,4.65136,4.454684422162974,5.25603,5.157692211081487,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.58,E,-0.3316,1.4703,-22.239,-6.43911129997014,0.8478463975584712,Pathogenic,0.9923,pathogenic,-4.501,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I255T,NP_000537:p.Ile255Thr,"hg19,17:g.7577516_7577517delinsAG, hg19,17:g.7577517A>G, hg19,17:g.7674199A>G, hg38,17:g.7674198_7674199delinsAG, hg38,17:g.7674199A>G",,,0.948,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376623,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.93561,3.0750977993011475,2.96633,3.05862325820328,3.45097,3.4971166291016402,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.58,E,-0.2484,1.4703,-22.239,-6.43911129997014,0.8272273603648213,Pathogenic,0.9812,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I255V,NP_000537:p.Ile255Val,"hg19,17:g.7577518T>C, hg38,17:g.7674200T>C",,,0.628,"COSMIC,ClinVar,saturation_mutlist",3242231,,,,,Tier IV - Benign/Likely benign,0,P53 DNA-binding domain (PF00870),2.60.40.720,1.37732,1.1325275897979736,0.82109,0.8588109167143767,1.099205,1.1180654583571883,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.58,E,-0.029,1.4703,-1.2098,-1.75416370524352,3.188483186119049e-05,Benign,0.1835,benign,-3.184,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +I255W,NP_000537:p.Ile255Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,16.62412,2.0337061882019043,2.76429,2.358537046521344,9.694205,9.491328523260673,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.58,E,-0.3409,1.4703,-22.239,-4.05758481142232,0.0862977783209384,Benign,0.9957,pathogenic,-4.376,available,https://doi.org/10.1101/2022.10.22.513328 +I255Y,NP_000537:p.Ile255Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.78633,2.010070562362671,2.13878,1.8824565091937235,3.962555,3.834393254596862,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.442,,,,,,,,,0.0,,True,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.58,E,-0.3497,1.4703,-22.239,-4.62349728709182,0.460097822430985,Uncertain,0.9883,pathogenic,-4.387,available,https://doi.org/10.1101/2022.10.22.513328 +T256A,NP_000537:p.Thr256Ala,"hg19,17:g.7577515T>C, hg38,17:g.7674197T>C",,,0.909,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141011,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.74132,0.5453857779502869,1.00102,0.0848883317649967,1.37117,0.9131041658824983,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,DOWN,neutral,neutral,False,neutral,neutral,98.54,E,-0.3146,0.0888,-22.239,-4.85637614669093,0.8649737807577336,Pathogenic,0.8745,pathogenic,-4.116,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T256C,NP_000537:p.Thr256Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.46354,0.1460129022598266,0.87789,0.441061987307087,1.170715,0.9523009936535436,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,DOWN,neutral,neutral,False,neutral,neutral,98.54,E,-0.3504,0.0888,-22.239,-3.49866155747281,0.8188868470317971,Pathogenic,0.9437,pathogenic,-4.254,available,https://doi.org/10.1101/2022.10.22.513328 +T256D,NP_000537:p.Thr256Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.98122,1.121759057044983,1.70544,0.7780020425243963,2.34333,1.8796110212621981,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,98.54,E,-0.4302,0.0888,-22.239,-6.91649716536948,0.8575983207042241,Pathogenic,0.9924,pathogenic,-4.768,available,https://doi.org/10.1101/2022.10.22.513328 +T256E,NP_000537:p.Thr256Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.57699,0.527438223361969,0.73707,0.0993345910825871,1.15703,0.8381622955412935,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.4055,0.0888,-22.239,-6.91649716536948,0.6903681600919974,Pathogenic,0.9909,pathogenic,-4.539,available,https://doi.org/10.1101/2022.10.22.513328 +T256F,NP_000537:p.Thr256Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.84573,0.3438045978546142,-0.67619,-1.3064756868172445,0.58477,0.2696271565913778,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.4219,0.0888,-22.239,-8.08902677723851,0.8189513046682451,Pathogenic,0.9834,pathogenic,-4.502,available,https://doi.org/10.1101/2022.10.22.513328 +T256G,NP_000537:p.Thr256Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.07986,2.0271005630493164,2.9534,1.7579750048487586,3.01663,2.4189175024243794,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,DOWN,neutral,neutral,False,neutral,neutral,98.54,E,-0.3881,0.0888,-22.239,-8.08902677723851,0.8708643519453154,Pathogenic,0.9349,pathogenic,-4.514,available,https://doi.org/10.1101/2022.10.22.513328 +T256H,NP_000537:p.Thr256His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.62436,0.9237765073776244,0.64626,-0.5745410551454105,2.13531,1.5249094724272947,Uncertain,Uncertain,Neutral,Uncertain,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.4022,0.0888,-22.239,-8.08902677723851,0.8572835831300849,Pathogenic,0.9534,pathogenic,-4.574,available,https://doi.org/10.1101/2022.10.22.513328 +T256I,NP_000537:p.Thr256Ile,"hg19,17:g.7577514G>A, hg19,17:g.7674196G>A, hg38,17:g.7674196G>A",,,0.932,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",858889,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.7862,-0.2500267028808594,-0.23946,-1.07865051300227,-0.51283,-0.9324252565011351,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.3405,0.0888,-22.239,-6.440376219923,0.2848579304509337,Benign,0.975,pathogenic,-3.965,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T256K,NP_000537:p.Thr256Lys,"hg19,17:g.7577514G>T, hg38,17:g.7674196G>T",,,0.936,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2826159,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.52209,1.2911529541015625,2.03741,-0.0642623515180229,1.27975,0.22891382424098858,Uncertain,Neutral,Uncertain,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.3977,0.0888,-22.239,-7.81772897076735,0.8396729730775638,Pathogenic,0.9946,pathogenic,-4.526,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T256L,NP_000537:p.Thr256Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.91792,-0.1156935691833496,-0.71361,-1.3595056129459164,-0.815765,-1.1387128064729581,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.3925,0.0888,-22.239,-6.39053795770667,0.6214769584916905,Uncertain,0.8612,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328 +T256M,NP_000537:p.Thr256Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.94419,-0.1289957761764526,0.40272,-0.7711370683590474,-0.27073499999999995,-0.8576635341795237,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.3594,0.0888,-22.239,-6.98010707437491,0.7294850422104464,Pathogenic,0.7838,pathogenic,-4.153,available,https://doi.org/10.1101/2022.10.22.513328 +T256N,NP_000537:p.Thr256Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.99203,1.1954920291900637,1.06395,0.0021187855821841,1.52799,0.997074392791092,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,98.54,E,-0.3702,0.0888,-22.239,-5.89880588250078,0.5974895569380456,Uncertain,0.8675,pathogenic,-4.02,available,https://doi.org/10.1101/2022.10.22.513328 +T256P,NP_000537:p.Thr256Pro,"hg19,17:g.7577515T>G, hg19,17:g.7674197T>G, hg38,17:g.7674197T>G",,,0.945,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",528269,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.31016,2.9664855003356934,3.37619,3.624621874327097,2.843175,2.9673909371635485,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,98.54,E,-0.4111,0.0888,-8.9511,-8.08902677723851,0.5663531514186722,Uncertain,0.9887,pathogenic,-4.363,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T256Q,NP_000537:p.Thr256Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.03055,0.6316127777099609,0.27449,-0.1593265645668073,-0.37803000000000003,-0.5949382822834037,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.3797,0.0888,-22.239,-5.73987309400099,0.4649424015587644,Uncertain,0.9678,pathogenic,-4.281,available,https://doi.org/10.1101/2022.10.22.513328 +T256R,NP_000537:p.Thr256Arg,"hg19,17:g.7577514G>C, hg38,17:g.7674196G>C",,,0.935,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.85453,0.9856072664260864,1.68469,-0.8068812892299143,1.2696100000000001,0.02382435538504285,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.4006,0.0888,-22.239,-7.67905902354375,0.6420822362092966,Uncertain,0.9902,pathogenic,-4.345,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T256S,NP_000537:p.Thr256Ser,"hg38,17:g.7674197T>A",,,0.846,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.50921,0.6592571139335632,1.57755,0.780950971650359,1.54338,1.1450804858251795,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,neutral,,,DOWN,neutral,neutral,False,neutral,neutral,98.54,E,-0.2003,0.0888,-6.9513,-2.22859017085069,0.009839484787646,Benign,0.4732,ambiguous,-3.532,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T256V,NP_000537:p.Thr256Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.00069,-0.443273663520813,-0.43435,-0.8937051801217027,-0.21683,-0.4465075900608514,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.3281,0.0888,-22.239,-6.98010707437491,0.869833277481687,Pathogenic,0.94,pathogenic,-4.312,available,https://doi.org/10.1101/2022.10.22.513328 +T256W,NP_000537:p.Thr256Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.62225,0.0988662242889404,-0.68299,-1.4081978438171272,0.9696300000000001,0.6070260780914365,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.4148,0.0888,-22.239,-8.08902677723851,0.8613228723652996,Pathogenic,0.9941,pathogenic,-4.73,available,https://doi.org/10.1101/2022.10.22.513328 +T256Y,NP_000537:p.Thr256Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.18586,0.2822920083999634,-0.13469,-0.993540661508494,2.025585,1.596159669245753,Uncertain,Uncertain,Neutral,Uncertain,Neutral,True,0.31,,,,,,,,,15.4,,True,15.4,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.4233,0.0888,-22.239,-8.08902677723851,0.842929572212407,Pathogenic,0.9834,pathogenic,-4.554,available,https://doi.org/10.1101/2022.10.22.513328 +L257A,NP_000537:p.Leu257Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.07908,3.0893142223358154,3.52415,3.991148878462521,4.301615,4.53511443923126,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.43,E,-0.4106,0.0969,-22.239,-7.70269970020109,0.8035756844176039,Pathogenic,0.9721,pathogenic,-4.526,available,https://doi.org/10.1101/2022.10.22.513328 +L257C,NP_000537:p.Leu257Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.49114,2.13731336593628,3.3034,3.874359207697594,3.39727,3.682749603848797,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.43,E,-0.3998,0.0969,-22.239,-7.70269970020109,0.8707925809280603,Pathogenic,0.9737,pathogenic,-4.412,available,https://doi.org/10.1101/2022.10.22.513328 +L257D,NP_000537:p.Leu257Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.15887,3.6340644359588623,5.16735,5.136845465757451,5.16311,5.147857732878726,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.43,E,-0.5321,0.0969,-22.239,-8.13493771905467,0.8653884843729469,Pathogenic,0.9999,pathogenic,-4.886,available,https://doi.org/10.1101/2022.10.22.513328 +L257E,NP_000537:p.Leu257Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.53618,3.565234661102295,3.60476,4.532304498855997,4.07047,4.534242249427999,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.43,E,-0.5002,0.0969,-22.239,-8.13493771905467,0.8700700904934778,Pathogenic,0.9984,pathogenic,-4.777,available,https://doi.org/10.1101/2022.10.22.513328 +L257F,NP_000537:p.Leu257Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.77879,2.0765175819396973,1.02177,1.7950934701792032,4.40028,4.786941735089601,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.43,E,-0.344,0.0969,-22.239,-8.13493771905467,0.7893772274689376,Pathogenic,0.9477,pathogenic,-4.259,available,https://doi.org/10.1101/2022.10.22.513328 +L257G,NP_000537:p.Leu257Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.68636,3.647994518280029,6.19218,6.305026624387812,6.43927,6.4956933121939056,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.43,E,-0.4854,0.0969,-22.239,-8.13493771905467,0.8692530621620168,Pathogenic,0.9972,pathogenic,-4.77,available,https://doi.org/10.1101/2022.10.22.513328 +L257H,NP_000537:p.Leu257His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.09145,3.7434213161468506,3.81293,3.2282391466416387,5.45219,5.15984457332082,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.43,E,-0.453,0.0969,-22.239,-8.13493771905467,0.858509608348218,Pathogenic,0.9985,pathogenic,-4.604,available,https://doi.org/10.1101/2022.10.22.513328 +L257I,NP_000537:p.Leu257Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.4097,1.2965803146362305,1.32245,1.4515323607849229,1.366075,1.4306161803924615,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.43,E,-0.2847,0.0969,-22.239,-2.74715223047285,0.8376628116379503,Pathogenic,0.6331,pathogenic,-4.228,available,https://doi.org/10.1101/2022.10.22.513328 +L257K,NP_000537:p.Leu257Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.20423,3.670179843902588,4.99728,6.106598270123557,5.1007549999999995,5.655414135061779,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.43,E,-0.4992,0.0969,-22.239,-8.13493771905467,0.8474843110450943,Pathogenic,0.9972,pathogenic,-4.775,available,https://doi.org/10.1101/2022.10.22.513328 +L257M,NP_000537:p.Leu257Met,"hg19,17:g.7577512G>T",,,0.843,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.03856,1.4065096378326416,0.08469,1.476482902692733,0.023065000000000002,0.7189614513463666,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.43,E,-0.2402,0.0969,-8.9511,-2.2601558430761,0.0695531424165593,Benign,0.4883,ambiguous,-3.664,available,https://doi.org/10.1101/2022.10.22.513328 +L257N,NP_000537:p.Leu257Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.37149,3.710929393768311,3.81803,3.716428023453727,4.09476,4.043959011726863,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.43,E,-0.4784,0.0969,-22.239,-8.13493771905467,0.8694364088569443,Pathogenic,0.9993,pathogenic,-4.709,available,https://doi.org/10.1101/2022.10.22.513328 +L257P,NP_000537:p.Leu257Pro,"hg19,17:g.7577510_7577511delinsAG, hg19,17:g.7577511A>G, hg19,17:g.7674193A>G, hg38,17:g.7674193A>G",,,0.933,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458562,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.95692,3.546973466873169,5.97891,7.829713724303119,9.967915,10.89331686215156,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.43,E,-0.494,0.0969,-22.239,-8.13493771905467,0.8699140235098215,Pathogenic,0.9993,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L257Q,NP_000537:p.Leu257Gln,"hg19,17:g.7577511A>T, hg19,17:g.7674193A>T, hg38,17:g.7674193A>T",,,0.916,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12372,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.22719,3.59420108795166,2.50136,3.3018464477157297,3.364275,3.764518223857865,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.43,E,-0.4314,0.0969,-22.239,-8.13493771905467,0.8708566439614697,Pathogenic,0.9953,pathogenic,-4.524,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L257R,NP_000537:p.Leu257Arg,"hg19,17:g.7577511A>C, hg19,17:g.7674193A>C, hg38,17:g.7674193A>C",,,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142134,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.21354,3.7972874641418457,5.77755,4.928437064402072,6.995545,6.570988532201036,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.43,E,-0.4179,0.0969,-7.9512,-8.13493771905467,0.859800224331768,Pathogenic,0.9938,pathogenic,-4.676,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L257S,NP_000537:p.Leu257Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.76657,3.6184628009796143,4.40544,4.925837914525658,4.586005,4.846203957262829,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.43,E,-0.441,0.0969,-22.239,-7.70269970020109,0.8702107084719308,Pathogenic,0.998,pathogenic,-4.608,available,https://doi.org/10.1101/2022.10.22.513328 +L257T,NP_000537:p.Leu257Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.19329,3.41657829284668,3.39694,3.700140998650269,3.295115,3.4467154993251343,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.43,E,-0.3408,0.0969,-7.9512,-5.51087021326529,0.7995310199328023,Pathogenic,0.9884,pathogenic,-4.226,available,https://doi.org/10.1101/2022.10.22.513328 +L257V,NP_000537:p.Leu257Val,"hg19,17:g.7577512G>C, hg19,17:g.7674194G>C, hg38,17:g.7674194G>C",,,0.896,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",827201,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.98389,1.8013970851898191,1.62449,1.8394744614530407,1.80419,1.9116822307265204,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.43,E,-0.321,0.0969,-22.239,-4.88168786702626,0.8706195464171612,Pathogenic,0.6232,pathogenic,-4.144,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L257W,NP_000537:p.Leu257Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,14.14946,2.991395235061645,0.86531,3.3879931119724827,7.507384999999999,8.768726555986241,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.43,E,-0.4432,0.0969,-22.239,-8.13493771905467,0.8666430998369268,Pathogenic,0.9956,pathogenic,-4.709,available,https://doi.org/10.1101/2022.10.22.513328 +L257Y,NP_000537:p.Leu257Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.01602,3.042810440063477,1.67891,3.247630087248328,7.347465,8.131825043624163,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.218,,,,,,,,,0.1,,True,0.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.43,E,-0.4361,0.0969,-22.239,-8.13493771905467,0.8689679678762479,Pathogenic,0.9965,pathogenic,-4.656,available,https://doi.org/10.1101/2022.10.22.513328 +E258A,NP_000537:p.Glu258Ala,"hg19,17:g.7577508T>G, hg19,17:g.7674190T>G, hg38,17:g.7674190T>G",,,0.955,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458563,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.22924,1.613405704498291,1.7881,0.9639845056187784,2.50867,2.096612252809389,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.32,E,-0.3206,0.0001,-22.239,-7.58032490440679,0.8700270825934455,Pathogenic,0.9822,pathogenic,-4.518,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258C,NP_000537:p.Glu258Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.60552,0.8475075960159302,1.94898,1.309358999541367,2.27725,1.9574394997706834,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.32,E,-0.39,0.0001,-22.239,-7.58032490440679,0.8466672674539686,Pathogenic,0.995,pathogenic,-4.585,available,https://doi.org/10.1101/2022.10.22.513328 +E258D,NP_000537:p.Glu258Asp,"hg19,17:g.7577507T>A, hg19,17:g.7577507T>G, hg19,17:g.7674189T>A, hg38,17:g.7674189T>A, hg38,17:g.7674189T>G",,,0.897,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1360091,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.0473,2.04364013671875,2.41735,0.9810289235418576,2.732325,2.0141644617709287,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.32,E,-0.2864,0.0001,-22.239,-4.93330392418067,0.8383242794957786,Pathogenic,0.9944,pathogenic,-4.333,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258F,NP_000537:p.Glu258Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.2718,1.392348289489746,-0.47857,0.1145404868984101,0.8966149999999999,1.1931702434492049,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.32,E,-0.3676,0.0001,-22.239,-8.22023741839059,0.8442742802342119,Pathogenic,0.9995,pathogenic,-4.763,available,https://doi.org/10.1101/2022.10.22.513328 +E258G,NP_000537:p.Glu258Gly,"hg19,17:g.7577508T>C, hg19,17:g.7674190T>C, hg38,17:g.7674190T>C",,,0.952,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406590,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.55249,2.4370360374450684,3.57891,2.0953391272861865,3.5657,2.8239145636430933,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.32,E,-0.3464,0.0001,-22.239,-8.22023741839059,0.8688495611048404,Pathogenic,0.9859,pathogenic,-4.548,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258H,NP_000537:p.Glu258His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.69998,1.756224274635315,0.56259,0.5077588532888718,1.631285,1.603869426644436,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.32,E,-0.3589,0.0001,-22.239,-8.22023741839059,0.8630845360891406,Pathogenic,0.9977,pathogenic,-4.506,available,https://doi.org/10.1101/2022.10.22.513328 +E258I,NP_000537:p.Glu258Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.2496,0.96528959274292,1.00646,-0.0479774121936238,1.1280299999999999,0.6008112939031881,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.32,E,-0.373,0.0001,-22.239,-8.22023741839059,0.8647194537912188,Pathogenic,0.9963,pathogenic,-4.63,available,https://doi.org/10.1101/2022.10.22.513328 +E258K,NP_000537:p.Glu258Lys,"hg19,17:g.7577509C>T, hg19,17:g.7577509_7577510delinsTT, hg19,17:g.7674191C>T, hg38,17:g.7674191C>T, hg38,17:g.7674191_7674192delinsTT",,,0.961,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","4082532, 12348","Likely pathogenic, Pathogenic/Likely pathogenic","1, 2",Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.49324,2.460599899291992,1.87347,1.0403019750231473,2.183355,1.7667709875115736,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.32,E,-0.3426,0.0001,-22.239,-7.66904678040932,0.8699085265877404,Pathogenic,0.9918,pathogenic,-4.464,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258L,NP_000537:p.Glu258Leu,"hg38,17:g.7674190_7674191delinsAA",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.05355,1.4258058071136477,0.4619,-0.237544643263694,0.757725,0.40800267836815296,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.32,E,-0.3751,0.0001,-22.239,-8.22023741839059,0.8701277011232702,Pathogenic,0.9966,pathogenic,-4.556,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258M,NP_000537:p.Glu258Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.10865,0.9894946813583374,0.70408,0.3361186192825965,0.906365,0.7223843096412982,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.32,E,-0.3239,0.0001,-22.239,-8.22023741839059,0.8615661797678273,Pathogenic,0.995,pathogenic,-4.63,available,https://doi.org/10.1101/2022.10.22.513328 +E258N,NP_000537:p.Glu258Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.80729,2.390997886657715,1.6983,0.9785035863219906,2.252795,1.8928967931609955,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.32,E,-0.3468,0.0001,-22.239,-4.93330392418067,0.8477451946398606,Pathogenic,0.9989,pathogenic,-4.698,available,https://doi.org/10.1101/2022.10.22.513328 +E258P,NP_000537:p.Glu258Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.11508,3.5956521034240723,4.64694,3.9744802714051897,5.88101,5.544780135702595,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.32,E,-0.4776,0.0001,-22.239,-6.56542053406238,0.8112485469762636,Pathogenic,0.9997,pathogenic,-4.794,available,https://doi.org/10.1101/2022.10.22.513328 +E258Q,NP_000537:p.Glu258Gln,"hg19,17:g.7577509C>G, hg19,17:g.7674191C>G, hg38,17:g.7674191C>G",,,0.936,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.86537,0.7796988487243652,0.49116,0.6898351520856366,1.178265,1.2776025760428182,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.32,E,-0.2932,0.0001,-22.239,-4.33439569529132,0.664038973726442,Uncertain,0.9505,pathogenic,-4.085,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258R,NP_000537:p.Glu258Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.81536,2.639580488204956,1.46939,0.6528547521151481,1.642375,1.234107376057574,Neutral,Neutral,Destabilizing,Neutral,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.32,E,-0.4031,0.0001,-22.239,-7.33311676482505,0.4556924294295201,Uncertain,0.9905,pathogenic,-4.354,available,https://doi.org/10.1101/2022.10.22.513328 +E258S,NP_000537:p.Glu258Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.08499,1.8454378843307493,2.40068,1.3351690747760887,2.742835,2.210079537388044,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.32,E,-0.3341,0.0001,-22.239,-7.58032490440679,0.8661646181794377,Pathogenic,0.991,pathogenic,-4.639,available,https://doi.org/10.1101/2022.10.22.513328 +E258T,NP_000537:p.Glu258Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.27965,1.1067757606506348,1.51156,0.8237031671958758,1.8956050000000002,1.551676583597938,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.32,E,-0.35,0.0001,-22.239,-5.85665866064952,0.8708637148309493,Pathogenic,0.9906,pathogenic,-4.519,available,https://doi.org/10.1101/2022.10.22.513328 +E258V,NP_000537:p.Glu258Val,"hg19,17:g.7577508T>A, hg38,17:g.7674190T>A",,,0.963,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2808296,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.88463,0.5767034292221069,0.85646,0.198306310659051,1.370545,1.0414681553295255,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.32,E,-0.3339,0.0001,-22.239,-8.22023741839059,0.8197832286795876,Pathogenic,0.9887,pathogenic,-4.478,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E258W,NP_000537:p.Glu258Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.44412,2.051942586898804,0.14626,-0.1736425019063237,1.7951899999999998,1.635238749046838,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.32,E,-0.3777,0.0001,-22.239,-8.22023741839059,0.8549879951400899,Pathogenic,0.9996,pathogenic,-4.838,available,https://doi.org/10.1101/2022.10.22.513328 +E258Y,NP_000537:p.Glu258Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.82918,1.5945391654968262,0.31429,0.1863079177283388,1.571735,1.5077439588641695,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.103,,,,,,,,,9.0,,True,9.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.32,E,-0.3685,0.0001,-22.239,-8.22023741839059,0.8558720996328555,Pathogenic,0.9991,pathogenic,-4.764,available,https://doi.org/10.1101/2022.10.22.513328 +D259A,NP_000537:p.Asp259Ala,"hg19,17:g.7577505T>G, hg38,17:g.7674187T>G",,,0.691,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2671888,Pathogenic,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.26481,2.7077014446258545,2.80408,1.5500520319313362,2.534445,1.9074310159656682,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.12,-,-0.1392,1.3643,-5.7784,-1.70989184504227,0.0022733266521254,Benign,0.8494,pathogenic,-3.599,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259C,NP_000537:p.Asp259Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.91439,1.6904935836791992,3.18299,2.288227807307968,3.04869,2.601308903653984,Uncertain,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.12,-,-0.2646,1.3643,-22.2361,-2.57012179162441,0.0955584467050807,Benign,0.9449,pathogenic,-3.959,available,https://doi.org/10.1101/2022.10.22.513328 +D259E,NP_000537:p.Asp259Glu,"hg19,17:g.7577504G>T, hg38,17:g.7674186G>T",,,0.564,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.81995,2.51617693901062,3.56633,1.3884091334402977,3.1931399999999996,2.104179566720149,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.12,-,-0.1681,1.3643,-22.2361,-3.87769875406997,0.080933087715221,Benign,0.8705,pathogenic,-3.787,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259F,NP_000537:p.Asp259Phe,"hg19,17:g.7577505_7577506delinsAA",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.03773,2.644987106323242,5.04388,1.4602228315686516,3.5408049999999998,1.7489764157843257,Uncertain,Uncertain,Destabilizing,Destabilizing,Neutral,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.12,-,-0.3233,1.3643,-22.2361,-4.92934531738054,0.3081588402702837,Benign,0.9834,pathogenic,-4.329,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259G,NP_000537:p.Asp259Gly,"hg19,17:g.7577505T>C, hg38,17:g.7674187T>C",,3.9774716009e-06,0.655,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",188349,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42994,2.035451889038086,3.56837,2.2537649329218112,2.499155,1.8418524664609057,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.12,-,-0.1503,1.3643,-5.7784,-2.8331597668249,3.225835084072401e-05,Benign,0.6494,pathogenic,-3.505,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259H,NP_000537:p.Asp259His,"hg19,17:g.7577506C>G, hg19,17:g.7674188C>G, hg38,17:g.7674188C>G",,,0.714,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1349622,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.2477,2.461765766143799,4.36769,1.1961077924068926,4.307695,2.7219038962034463,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.12,-,-0.2325,1.3643,-22.2361,-4.02744588332535,0.0144226157941884,Benign,0.9217,pathogenic,-3.83,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259I,NP_000537:p.Asp259Ile,"hg19,17:g.7577505_7577506delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.45525,3.372515916824341,4.47517,1.6641583640828954,3.96521,2.5597041820414477,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.12,-,-0.3155,1.3643,-22.2361,-4.38224410620792,0.2702251996198974,Benign,0.9856,pathogenic,-4.22,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259K,NP_000537:p.Asp259Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.56787,2.994828939437866,4.79014,1.7032198680146604,3.179005,1.6355449340073303,Uncertain,Neutral,Destabilizing,Destabilizing,Neutral,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.12,-,-0.2939,1.3643,-22.2361,-3.51300888565769,0.1169506431497978,Benign,0.9778,pathogenic,-3.866,available,https://doi.org/10.1101/2022.10.22.513328 +D259L,NP_000537:p.Asp259Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.84309,2.946181297302246,4.01463,1.145379166828527,2.9288600000000002,1.4942345834142634,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.12,-,-0.3092,1.3643,-22.2361,-3.66140819714008,0.047511114431095,Benign,0.9627,pathogenic,-3.978,available,https://doi.org/10.1101/2022.10.22.513328 +D259M,NP_000537:p.Asp259Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.01662,2.888439178466797,3.58027,1.3434838506928188,2.798445,1.6800519253464095,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.12,-,-0.1624,1.3643,-5.4889,-3.08077902066545,0.5127309581769595,Uncertain,0.982,pathogenic,-4.167,available,https://doi.org/10.1101/2022.10.22.513328 +D259N,NP_000537:p.Asp259Asn,"hg19,17:g.7577506C>T, hg19,17:g.7674188C>T, hg38,17:g.7674188C>T",,,0.532,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3634427,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.41764,0.9901723861694336,1.37007,1.0132118255830247,1.3938549999999998,1.2154259127915124,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.12,-,-0.1169,1.3643,-7.9483,-2.38353149124325,0.008458380545714,Benign,0.3388,benign,-3.511,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259P,NP_000537:p.Asp259Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.55944,3.7071218490600586,5.82823,3.701736571449096,5.193835,4.130588285724548,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.12,-,-0.3601,1.3643,-22.2361,-6.06473125273993,0.6040564678547501,Uncertain,0.9924,pathogenic,-4.396,available,https://doi.org/10.1101/2022.10.22.513328 +D259Q,NP_000537:p.Asp259Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.72914,2.727537155151367,3.73061,1.3985593590390488,3.229875,2.0638496795195245,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.12,-,-0.2501,1.3643,-22.2361,-3.21529273583598,0.0828247212520412,Benign,0.9639,pathogenic,-3.971,available,https://doi.org/10.1101/2022.10.22.513328 +D259R,NP_000537:p.Asp259Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.76127,2.906714677810669,4.68129,1.569483148090806,3.2212799999999997,1.665376574045403,Uncertain,Neutral,Destabilizing,Destabilizing,Neutral,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.12,-,-0.3249,1.3643,-22.2361,-3.5682057157072,0.0366652059799088,Benign,0.9801,pathogenic,-3.926,available,https://doi.org/10.1101/2022.10.22.513328 +D259S,NP_000537:p.Asp259Ser,"hg38,17:g.7674187_7674188delinsCT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.31753,1.6544901132583618,1.91259,1.5745745867720202,2.11506,1.94605229338601,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.12,-,-0.1418,1.3643,-5.0415,-1.16439102148646,4.513714236519315e-07,Benign,0.5538,ambiguous,-3.324,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259T,NP_000537:p.Asp259Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.46395,2.4180617332458496,3.3898,1.607683526090117,3.426875,2.5358167630450588,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.12,-,-0.1487,1.3643,-0.5137,-1.12290732943819,1.4991491788158542e-08,Benign,0.7583,pathogenic,-3.165,available,https://doi.org/10.1101/2022.10.22.513328 +D259V,NP_000537:p.Asp259Val,"hg19,17:g.7577505T>A, hg19,17:g.7674187T>A, hg38,17:g.7674186_7674187delinsAA, hg38,17:g.7674187T>A",,,0.742,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",485034,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.60796,3.367535352706909,4.01565,1.6405680523570023,3.8118049999999997,2.6242640261785013,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.12,-,-0.2702,1.3643,-22.2361,-4.70426656490911,0.5979896659917047,Uncertain,0.9451,pathogenic,-4.176,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D259W,NP_000537:p.Asp259Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.1273,2.671823501586914,5.0881,1.2556522237725016,4.6076999999999995,2.6914761118862507,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.12,-,-0.3037,1.3643,-22.2361,-4.92934531738054,0.7404677960501027,Pathogenic,0.9962,pathogenic,-4.547,available,https://doi.org/10.1101/2022.10.22.513328 +D259Y,NP_000537:p.Asp259Tyr,"hg19,17:g.7577506C>A, hg19,17:g.7674188C>A, hg38,17:g.7674188C>A",,,0.737,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634680,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.23444,3.0300769805908203,3.9966,1.6227609589272944,3.11552,1.9286004794636473,Uncertain,Uncertain,Destabilizing,Destabilizing,Neutral,False,0.052,,,Uncertain,,Uncertain,,,Uncertain,32.8,,True,32.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.12,-,-0.2003,1.3643,-8.9482,-2.53379256730248,0.0232235630979985,Benign,0.8837,pathogenic,-3.966,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S260A,NP_000537:p.Ser260Ala,"hg38,17:g.7674185A>C",,,0.599,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.38004,-0.0429030656814575,-0.10544,0.0459494255794318,-0.24274,-0.16704528721028408,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,96.11,T,-0.0117,2.008,-5.7813,-0.38674266409016,8.008240952324595e-08,Benign,0.0661,benign,-3.033,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S260C,NP_000537:p.Ser260Cys,"hg19,17:g.7577502G>C, hg38,17:g.7674184G>C",,,0.660,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.17099,0.2945905923843384,0.66054,0.6932074410181607,0.415765,0.4320987205090803,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.1462,2.008,-22.239,-2.11362212266492,0.0082748220277151,Benign,0.0973,benign,-3.462,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S260D,NP_000537:p.Ser260Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14992,0.6512815356254578,0.72857,0.0361694447756277,0.439245,0.09304472238781385,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.1944,2.008,-22.239,-3.07923079775833,0.058320831697469,Benign,0.2697,benign,-3.53,available,https://doi.org/10.1101/2022.10.22.513328 +S260E,NP_000537:p.Ser260Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.10746,0.3423100709915161,0.25884,0.001215922943375,0.07569000000000001,-0.0531220385283125,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.0998,2.008,-8.9511,-2.28614415024623,0.0146926751219765,Benign,0.3196,benign,-3.31,available,https://doi.org/10.1101/2022.10.22.513328 +S260F,NP_000537:p.Ser260Phe,"hg19,17:g.7577502G>A, hg38,17:g.7674184G>A",,,0.636,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2765819,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.35817,0.8412783145904541,-0.01973,-0.2756342380781973,-0.18895,-0.31690211903909865,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.106,2.008,-8.9511,-2.57687113446244,0.0641929303903014,Benign,0.1977,benign,-3.578,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S260G,NP_000537:p.Ser260Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.12873,0.4051845073699951,0.43503,0.7041837375981375,0.15314999999999998,0.2877268687990687,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.0371,2.008,-8.9511,-2.65757151669382,0.0162860394943667,Benign,0.0897,benign,-3.262,available,https://doi.org/10.1101/2022.10.22.513328 +S260H,NP_000537:p.Ser260His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.39364,0.5670020580291748,-0.08503,-0.2691797909795512,0.154305,0.0622301045102244,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.0889,2.008,-5.3663,-2.15963477321954,0.000212639580705,Benign,0.255,benign,-3.16,available,https://doi.org/10.1101/2022.10.22.513328 +S260I,NP_000537:p.Ser260Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.20549,0.7492443919181824,0.20884,-0.1979282862299058,0.207165,0.003780856885047104,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.1769,2.008,-22.239,-3.93109958189597,0.1394672752785239,Benign,0.1924,benign,-3.644,available,https://doi.org/10.1101/2022.10.22.513328 +S260K,NP_000537:p.Ser260Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.55027,0.3923578262329101,-0.04286,-0.1136393289042853,-0.296565,-0.33195466445214267,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.1012,2.008,-5.9513,-1.00594302893451,1.84044676979515e-08,Benign,0.515,ambiguous,-3.148,available,https://doi.org/10.1101/2022.10.22.513328 +S260L,NP_000537:p.Ser260Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.26036,0.7719340324401855,0.27891,-0.5815453922046288,0.009275000000000005,-0.42095269610231434,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.0952,2.008,-6.9513,-2.3755868189941,0.0041115638678851,Benign,0.1155,benign,-3.22,available,https://doi.org/10.1101/2022.10.22.513328 +S260M,NP_000537:p.Ser260Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.28814,0.6711132526397705,0.52857,-0.18550887746692,0.12021499999999999,-0.23682443873345999,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.1442,2.008,-22.239,-4.21462642092151,0.1026279299939304,Benign,0.2123,benign,-3.45,available,https://doi.org/10.1101/2022.10.22.513328 +S260N,NP_000537:p.Ser260Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.2303,0.5848208069801331,0.55442,0.067331776729253,0.39236000000000004,0.1488158883646265,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.0421,2.008,-7.3663,-1.82677753753766,0.0003776364950087,Benign,0.1465,benign,-3.282,available,https://doi.org/10.1101/2022.10.22.513328 +S260P,NP_000537:p.Ser260Pro,"hg19,17:g.7577503A>G, hg38,17:g.7674185A>G",,,0.659,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.50451,0.3946372270584106,3.22449,0.8135062524278444,0.8599899999999999,-0.34550187378607783,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.1533,2.008,-3.4594,-0.672831220077273,1.2133532166864592e-06,Benign,0.0896,benign,-3.008,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S260Q,NP_000537:p.Ser260Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.11888,0.3629255890846252,0.01156,0.0349534665238704,-0.05366,-0.0419632667380648,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.0456,2.008,-4.1964,-1.86364294399756,1.0124058415458133e-05,Benign,0.3127,benign,-3.078,available,https://doi.org/10.1101/2022.10.22.513328 +S260R,NP_000537:p.Ser260Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.0083,0.4808384776115417,0.21531,-0.3420731788008418,-0.396495,-0.6751865894004209,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.0802,2.008,-0.8066,-1.01592776987403,0.0001437706925,Benign,0.4246,ambiguous,-3.118,available,https://doi.org/10.1101/2022.10.22.513328 +S260T,NP_000537:p.Ser260Thr,"hg19,17:g.7577503A>T",,,0.530,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.72563,0.4875730276107788,0.72381,-0.07244413255308,0.72472,0.32659293372346,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,neutral,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.0084,2.008,-6.9513,-1.98572016214949,0.0048245155574749,Benign,0.0865,benign,-3.246,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S260V,NP_000537:p.Ser260Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.48499,0.667407751083374,0.28197,-0.0224545349393356,0.38348,0.2312677325303322,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.1512,2.008,-22.239,-3.97940771885032,0.0525638560221948,Benign,0.1673,benign,-3.514,available,https://doi.org/10.1101/2022.10.22.513328 +S260W,NP_000537:p.Ser260Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.65449,0.7680002450942993,0.0051,-0.8932456676685779,-0.324695,-0.773867833834289,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.1835,2.008,-22.239,-4.1221197690896,0.471663584821703,Uncertain,0.3256,benign,-3.902,available,https://doi.org/10.1101/2022.10.22.513328 +S260Y,NP_000537:p.Ser260Tyr,"hg19,17:g.7577502G>T, hg38,17:g.7674184G>T",,3.9771552204e-06,0.668,"COSMIC,ClinVar,saturation_mutlist",231033,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.29726,0.7965068221092224,-0.18197,-0.2566382437992653,-0.23961500000000002,-0.27694912189963267,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.037,,,Uncertain,,Uncertain,,,Uncertain,70.9,,True,70.9,,uncertain,,,UP,stabilizing,neutral,False,neutral,neutral,96.11,T,-0.1786,2.008,-22.239,-3.82739574834943,0.0730383899636282,Benign,0.2029,benign,-3.698,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261A,NP_000537:p.Ser261Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.20904,0.056268036365509,0.51531,0.0449309422109189,0.362175,0.12698547110545946,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,-,uncertain,neutral,False,neutral,neutral,95.91,T,-0.055,1.7131,-8.9453,-2.04022371982166,0.0009756908758932,Benign,0.0873,benign,-3.25,available,https://doi.org/10.1101/2022.10.22.513328 +S261C,NP_000537:p.Ser261Cys,"hg38,17:g.7674182T>A",,,0.547,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.68283,-0.53648442029953,0.97653,0.6292922689472058,0.82968,0.6560611344736029,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.1004,1.7131,-7.9454,-0.502208726640067,0.0178114924795914,Benign,0.087,benign,-3.37,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261D,NP_000537:p.Ser261Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.47819,0.0199969410896301,0.28265,-0.2737937112402028,0.38042,0.1021981443798986,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.1113,1.7131,-0.6462,-0.875788802920189,2.7135721951607856e-08,Benign,0.1721,benign,-2.992,available,https://doi.org/10.1101/2022.10.22.513328 +S261E,NP_000537:p.Ser261Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.11836,-0.0536795258522033,0.39796,-0.2139726545484171,0.25816,-0.04780632727420855,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.0971,1.7131,-3.1126,-0.946725575828048,1.50672951385436e-07,Benign,0.2859,benign,-3.047,available,https://doi.org/10.1101/2022.10.22.513328 +S261F,NP_000537:p.Ser261Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.56028,-0.174397587776184,0.22449,-0.2419376609089746,-0.16789500000000002,-0.4011088304544873,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.2009,1.7131,-22.2332,-4.61296027217296,0.0588126939535827,Benign,0.2061,benign,-3.572,available,https://doi.org/10.1101/2022.10.22.513328 +S261G,NP_000537:p.Ser261Gly,"hg19,17:g.7577500T>C, hg38,17:g.7674182T>C",,,0.529,"COSMIC,ClinVar,saturation_mutlist",1383522,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.33326,0.4406147599220276,0.85748,0.4758758507879645,0.59537,0.40456792539398223,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,DOWN,stabilizing,neutral,False,neutral,neutral,95.91,T,-0.0561,1.7131,-7.3604,-2.17914337186216,2.019823258804172e-06,Benign,0.0786,benign,-3.105,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261H,NP_000537:p.Ser261His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.30061,-0.3330622315406799,0.1017,-0.3752009309205928,0.701155,0.4627045345397036,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.1224,1.7131,-6.6235,-2.5578206679946,8.879736881525837e-05,Benign,0.1504,benign,-3.187,available,https://doi.org/10.1101/2022.10.22.513328 +S261I,NP_000537:p.Ser261Ile,"hg19,17:g.7577499C>A, hg38,17:g.7674181C>A",,,0.532,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.25136,0.4542361497879028,1.63844,-0.0214046295908171,1.4449,0.6149776852045915,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.204,1.7131,-22.2332,-4.59122588609972,0.031828400675512,Benign,0.205,benign,-3.695,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261K,NP_000537:p.Ser261Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.10373,-0.0742520093917846,0.2381,-0.2455332166713564,0.170915,-0.07090160833567821,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.1436,1.7131,-8.9453,-2.48110060430245,0.000458313553013,Benign,0.3333,benign,-3.306,available,https://doi.org/10.1101/2022.10.22.513328 +S261L,NP_000537:p.Ser261Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.02982,-0.1662525534629821,0.20442,-0.5275706602765562,0.08729999999999999,-0.2786953301382781,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.1274,1.7131,-7.9454,-2.9753696704731,0.0026620882853516,Benign,0.1274,benign,-3.354,available,https://doi.org/10.1101/2022.10.22.513328 +S261M,NP_000537:p.Ser261Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.13246,-0.1517645716667175,0.88639,-0.1495262888136062,0.509425,-0.008533144406803098,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.1713,1.7131,-22.2332,-3.07376485559445,0.0002035752584973,Benign,0.187,benign,-3.428,available,https://doi.org/10.1101/2022.10.22.513328 +S261N,NP_000537:p.Ser261Asn,"hg19,17:g.7577499C>T, hg38,17:g.7674181C>T",,,0.446,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",4427935,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.70083,-0.4690415263175964,0.14422,-0.2553422329700272,0.422525,0.22274388351498636,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.0565,1.7131,-4.858,0.403774820524704,2.1237138844390275e-08,Benign,0.08,benign,-2.92,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261P,NP_000537:p.Ser261Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.35932,2.604583740234375,5.39592,2.467039331452913,3.3776200000000003,1.9131796657264566,Uncertain,Uncertain,Destabilizing,Destabilizing,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.2763,1.7131,-22.2332,-5.36520861972928,0.2444873835395251,Benign,0.7656,pathogenic,-3.868,available,https://doi.org/10.1101/2022.10.22.513328 +S261Q,NP_000537:p.Ser261Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.6958,-0.219374418258667,-0.29762,-0.0021936325134996,0.19909,0.3468031837432502,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.0851,1.7131,-6.6235,-1.11833664663487,4.135505109297147e-06,Benign,0.2217,benign,-3.077,available,https://doi.org/10.1101/2022.10.22.513328 +S261R,NP_000537:p.Ser261Arg,"hg19,17:g.7577500T>G, hg38,17:g.7673837A>C, hg38,17:g.7673837A>T, hg38,17:g.7674182T>G",,,"0.390, 0.391, 0.456","COSMIC,ClinVar,saturation_mutlist",3708635,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.24974,-0.0716381072998046,0.53639,-0.3292341556288319,0.14332500000000004,-0.28948707781441596,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.137,1.7131,-6.6235,-1.20713191968725,0.0029405925469668,Benign,0.2371,benign,-3.265,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261T,NP_000537:p.Ser261Thr,"hg19,17:g.7577499C>G, hg19,17:g.7674181C>G, hg38,17:g.7674181C>G",,,0.504,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",187005,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.72104,0.0664945840835571,-0.20612,0.0889366349123566,0.25746,0.4049883174561783,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,neutral,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.1135,1.7131,-22.2332,-2.87081743695043,0.0007919516612992,Benign,0.0875,benign,-3.192,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S261V,NP_000537:p.Ser261Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42309,0.3823842704296112,0.50748,-0.0989276925675958,0.965285,0.6620811537162021,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.1783,1.7131,-22.2332,-4.59122588609972,0.002339587213864,Benign,0.1984,benign,-3.696,available,https://doi.org/10.1101/2022.10.22.513328 +S261W,NP_000537:p.Ser261Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.37944,-0.0955857038497924,0.67891,-0.5361434185765285,0.529175,-0.07835170928826424,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.2106,1.7131,-22.2332,-4.61296027217296,0.2317543290742702,Benign,0.3039,benign,-3.899,available,https://doi.org/10.1101/2022.10.22.513328 +S261Y,NP_000537:p.Ser261Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.08793,-0.1696962118148803,0.10544,-0.1548767167741366,0.096685,-0.03347335838706831,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.026,,,Uncertain,,Uncertain,,,Uncertain,78.2,,True,78.2,,uncertain,,,UP,neutral,neutral,False,neutral,neutral,95.91,T,-0.2057,1.7131,-22.2332,-4.61296027217296,0.328653743854079,Uncertain,0.174,benign,-3.716,available,https://doi.org/10.1101/2022.10.22.513328 +G262A,NP_000537:p.Gly262Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.79601,1.39039409160614,0.71599,0.6858154288206758,1.756,1.7409127144103378,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.3782,0.0592,-22.2332,-5.73364708026077,0.5294729414423727,Uncertain,0.8367,pathogenic,-3.786,available,https://doi.org/10.1101/2022.10.22.513328 +G262C,NP_000537:p.Gly262Cys,"hg19,17:g.7577154C>A",,,0.865,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.77265,0.7407691478729248,1.12007,1.015999752878333,2.44636,2.3943248764391667,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.4379,0.0592,-22.2332,-6.35039706060677,0.7372361459513241,Pathogenic,0.8435,pathogenic,-3.974,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G262D,NP_000537:p.Gly262Asp,"hg19,17:g.7577153C>T, hg19,17:g.7673835C>T, hg38,17:g.7673835C>T",,,0.931,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2993845,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.90976,1.1139731407165527,1.23197,0.4339280782728999,2.570865,2.1718440391364497,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.4385,0.0592,-22.2332,-5.37575011432035,0.5855638912025629,Uncertain,0.9609,pathogenic,-3.886,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G262E,NP_000537:p.Gly262Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.71497,1.4227784872055054,0.53401,0.5581159851377123,1.62449,1.6365429925688562,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.3649,0.0592,-7.9454,-4.18735712970854,0.1193809237587507,Benign,0.9553,pathogenic,-3.754,available,https://doi.org/10.1101/2022.10.22.513328 +G262F,NP_000537:p.Gly262Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.22184,1.231184720993042,0.19864,-0.0472045264048537,0.71024,0.5873177367975732,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.476,0.0592,-22.2332,-7.33538990925361,0.8677240979352827,Pathogenic,0.9877,pathogenic,-4.323,available,https://doi.org/10.1101/2022.10.22.513328 +G262H,NP_000537:p.Gly262His,"hg38,17:g.7673835_7673836delinsTG",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.02755,1.2749555110931396,0.06735,0.1545835740953061,1.54745,1.5910667870476531,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.4508,0.0592,-22.2332,-7.33538990925361,0.8707630531421902,Pathogenic,0.9694,pathogenic,-4.323,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G262I,NP_000537:p.Gly262Ile,"hg19,17:g.7577153_7577154delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.15589,1.8100252151489256,4.26769,1.061524963631496,4.211790000000001,2.608707481815748,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.5217,0.0592,-22.2332,-7.33538990925361,0.869555621585437,Pathogenic,0.9959,pathogenic,-4.623,available,https://doi.org/10.1101/2022.10.22.513328 +G262K,NP_000537:p.Gly262Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.96317,1.5132122039794922,0.28844,0.3424325603738604,1.625805,1.65280128018693,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.4707,0.0592,-22.2332,-6.36573150035049,0.5632845925303624,Uncertain,0.9793,pathogenic,-3.985,available,https://doi.org/10.1101/2022.10.22.513328 +G262L,NP_000537:p.Gly262Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.47335,1.423146367073059,0.6619,-0.1525248327216266,1.567625,1.1604125836391868,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.4899,0.0592,-22.2332,-7.11273424087202,0.8518611188844114,Pathogenic,0.9785,pathogenic,-4.271,available,https://doi.org/10.1101/2022.10.22.513328 +G262M,NP_000537:p.Gly262Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.29107,1.342090129852295,1.05578,0.235386086672481,1.673425,1.2632280433362404,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.4282,0.0592,-22.2332,-7.33538990925361,0.87010628774238,Pathogenic,0.9865,pathogenic,-4.345,available,https://doi.org/10.1101/2022.10.22.513328 +G262N,NP_000537:p.Gly262Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.52715,1.0024940967559814,0.02177,0.0545387770872496,1.27446,1.2908443885436247,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.4388,0.0592,-22.2332,-5.0085921961254,0.3904992615459105,Uncertain,0.925,pathogenic,-3.722,available,https://doi.org/10.1101/2022.10.22.513328 +G262P,NP_000537:p.Gly262Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.67398,2.040565490722656,4.75034,6.546771817803025,5.21216,6.110375908901513,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.5359,0.0592,-22.2332,-7.86384531971252,0.8708566439614697,Pathogenic,0.9987,pathogenic,-4.539,available,https://doi.org/10.1101/2022.10.22.513328 +G262Q,NP_000537:p.Gly262Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.18045,1.4384270906448364,0.7898,0.595413693951042,1.485125,1.387931846975521,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.4417,0.0592,-22.2332,-5.49734300582471,0.6488772924991666,Uncertain,0.9255,pathogenic,-4.045,available,https://doi.org/10.1101/2022.10.22.513328 +G262R,NP_000537:p.Gly262Arg,"hg19,17:g.7577154C>G, hg38,17:g.7673836C>G",,,0.889,"COSMIC,ClinVar,saturation_mutlist",1760888,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.52572,1.5376890897750854,0.6119,0.1580920227279059,1.56881,1.3419060113639532,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.4547,0.0592,-22.2332,-5.79806747256491,0.5403141050472513,Uncertain,0.9274,pathogenic,-3.918,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G262S,NP_000537:p.Gly262Ser,"hg19,17:g.7577154C>T, hg19,17:g.7673836C>T, hg38,17:g.7673836C>T",3.186336987e-05,8.1725386357e-06,0.876,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141228,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.77225,1.3102130889892578,0.61259,1.0758373633906606,1.69242,1.9240436816953304,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.3841,0.0592,-22.2332,-6.34618526957259,0.7282729553086548,Pathogenic,0.6981,pathogenic,-3.856,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G262T,NP_000537:p.Gly262Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.91101,1.6489437818527222,1.55068,1.2479828311432364,2.730845,2.5794964155716182,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.3932,0.0592,-8.9453,-6.23904282959436,0.6711767143021219,Uncertain,0.9573,pathogenic,-4.229,available,https://doi.org/10.1101/2022.10.22.513328 +G262V,NP_000537:p.Gly262Val,"hg19,17:g.7577153C>A, hg19,17:g.7673835C>A, hg38,17:g.7673835C>A",,,0.929,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428889,Conflicting classifications of pathogenicity,1,Uncertain significance,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.77969,1.8087682723999023,4.80034,1.0679416255898917,4.790015,2.9238158127949463,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.465,0.0592,-22.2332,-7.33538990925361,0.8705260902226395,Pathogenic,0.9878,pathogenic,-4.432,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G262W,NP_000537:p.Gly262Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.14903,1.3027459383010864,0.43197,-0.2847332304825067,2.2904999999999998,1.9321483847587466,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.4758,0.0592,-22.2332,-7.33538990925361,0.8703351197825077,Pathogenic,0.973,pathogenic,-4.484,available,https://doi.org/10.1101/2022.10.22.513328 +G262Y,NP_000537:p.Gly262Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.84845,1.3394134044647217,0.08673,0.2174466372585937,0.96759,1.032948318629297,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.017,,,Uncertain,,Uncertain,,,Uncertain,48.0,,False,48.0,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,94.03,-,-0.4764,0.0592,-22.2332,-7.15246193613362,0.8068636906846784,Pathogenic,0.9783,pathogenic,-4.259,available,https://doi.org/10.1101/2022.10.22.513328 +N263A,NP_000537:p.Asn263Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.30705,0.2078839540481567,0.05102,0.3637086759681274,-0.128015,0.0283293379840637,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.1077,1.6112,-7.9454,-3.5389879530537,0.0008577695200733,Benign,0.1647,benign,-3.205,available,https://doi.org/10.1101/2022.10.22.513328 +N263C,NP_000537:p.Asn263Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.2192,-0.0382729768753051,0.49218,0.8536135807563902,0.35569,0.536406790378195,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.2305,1.6112,-22.2332,-4.44360904561772,0.002433512474041,Benign,0.1377,benign,-3.448,available,https://doi.org/10.1101/2022.10.22.513328 +N263D,NP_000537:p.Asn263Asp,"hg19,17:g.7577151T>C, hg38,17:g.7673833T>C",,0.0001136465106462,0.315,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142916,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.44651,0.7500057220458984,1.21088,0.4687617497497887,0.828695,0.4576358748748943,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.55,-,-0.116,1.6112,-8.9453,-3.16059060505359,0.0154966667641783,Benign,0.2109,benign,-3.394,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N263E,NP_000537:p.Asn263Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.0153,0.5286362767219543,0.73605,0.3256254703557543,0.360375,0.15516273517787715,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.1329,1.6112,-6.9454,-1.96554421769677,0.0001133959187897,Benign,0.2544,benign,-3.136,available,https://doi.org/10.1101/2022.10.22.513328 +N263F,NP_000537:p.Asn263Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.40406,0.3959807157516479,-0.0381,-0.2189500650856279,-0.22108,-0.3115050325428139,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.17,1.6112,-8.9453,-5.36611076407854,0.0385483194555927,Benign,0.3972,ambiguous,-3.668,available,https://doi.org/10.1101/2022.10.22.513328 +N263G,NP_000537:p.Asn263Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.02279,0.8023731112480164,0.99966,0.9525459648325836,0.488435,0.4648779824162918,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.1436,1.6112,-8.9453,-5.96632723085024,0.0408853670464283,Benign,0.2986,benign,-3.467,available,https://doi.org/10.1101/2022.10.22.513328 +N263H,NP_000537:p.Asn263His,"hg19,17:g.7577151T>G, hg38,17:g.7673833T>G, hg38,17:g.7673833_7673834delinsGT",,,0.315,"COSMIC,ClinVar,saturation_mutlist",528251,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.27739,0.1208767890930175,0.20986,-0.1196349908475735,-0.03376500000000002,-0.19851249542378677,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.1076,1.6112,-6.9454,-2.09937785895099,3.017920159696205e-05,Benign,0.0689,benign,-3.13,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N263I,NP_000537:p.Asn263Ile,"hg38,17:g.7673832T>A",,,0.318,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22337,0.4052419066429138,0.22959,-0.0868757288094479,0.22648000000000001,0.06824713559527606,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.158,1.6112,-7.9454,-3.16992684680608,0.0020597620732658,Benign,0.1494,benign,-3.474,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N263K,NP_000537:p.Asn263Lys,"hg19,17:g.7577149A>C, hg19,17:g.7577149A>T, hg38,17:g.7673831A>C, hg38,17:g.7673831A>T",,,0.213,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",485047,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.58197,-0.1452882289886474,-0.00306,0.1221692818851044,-0.29251499999999997,-0.2299003590574478,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.0999,1.6112,-5.7755,-1.63217552242182,5.5317864002968575e-05,Benign,0.1437,benign,-3.045,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N263L,NP_000537:p.Asn263Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.11841,0.27102130651474,-0.14456,-0.3713340677131083,-0.131485,-0.24487203385655415,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.1447,1.6112,-4.0875,-2.72522943396324,7.365307303741582e-05,Benign,0.1829,benign,-3.088,available,https://doi.org/10.1101/2022.10.22.513328 +N263M,NP_000537:p.Asn263Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.4397,0.175243079662323,0.08027,0.0827894339884055,-0.17971499999999999,-0.17845528300579724,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.1156,1.6112,-7.3604,-3.07863998203176,0.0002815627503223,Benign,0.2242,benign,-3.378,available,https://doi.org/10.1101/2022.10.22.513328 +N263P,NP_000537:p.Asn263Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.84377,3.0429234504699707,5.75952,4.911385645399805,3.301645,2.8775778226999025,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.55,-,-0.3462,1.6112,-22.2332,-4.62100007272057,0.2487050287926423,Benign,0.9564,pathogenic,-3.915,available,https://doi.org/10.1101/2022.10.22.513328 +N263Q,NP_000537:p.Asn263Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.11416,0.0611743927001953,0.04014,0.3757592448660068,-0.03701,0.13079962243300342,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.0639,1.6112,-0.5446,-0.947771734445837,7.045683281580252e-10,Benign,0.1273,benign,-2.794,available,https://doi.org/10.1101/2022.10.22.513328 +N263R,NP_000537:p.Asn263Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.93045,-0.2424862384796142,-0.54388,-0.2238404701603591,-0.7371650000000001,-0.5771452350801796,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.138,1.6112,-6.9454,-2.8855157720337,4.662204485019185e-05,Benign,0.1343,benign,-3.044,available,https://doi.org/10.1101/2022.10.22.513328 +N263S,NP_000537:p.Asn263Ser,"hg19,17:g.7577150T>C, hg38,17:g.7673832T>C",,,0.243,"cBioPortal,ClinVar,saturation_mutlist",827313,Likely benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.04319,0.3178014755249023,0.40374,0.6124566360180552,0.180275,0.28463331800902764,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.0776,1.6112,-7.9454,-2.50718463114567,3.469311402443688e-06,Benign,0.093,benign,-3.085,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N263T,NP_000537:p.Asn263Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.09547,0.366032600402832,-0.07211,0.3761894512571506,0.011680000000000003,0.2358297256285753,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.55,-,-0.1323,1.6112,-8.9453,-1.75573272354967,0.0114854338353704,Benign,0.1154,benign,-3.274,available,https://doi.org/10.1101/2022.10.22.513328 +N263V,NP_000537:p.Asn263Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.33541,0.3042235970497131,0.13571,-0.0841117505199634,0.23556,0.1256491247400183,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.1446,1.6112,-6.6235,-3.06010693003711,2.838152577811049e-05,Benign,0.1438,benign,-3.202,available,https://doi.org/10.1101/2022.10.22.513328 +N263W,NP_000537:p.Asn263Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.22411,0.4913810491561889,-0.34184,-0.4602867587423004,-0.282975,-0.3421983793711502,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.2429,1.6112,-22.2332,-5.36611076407854,0.4892516326995746,Uncertain,0.6572,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328 +N263Y,NP_000537:p.Asn263Tyr,"hg19,17:g.7577151T>A, hg38,17:g.7673833T>A",,,0.446,"cBioPortal,ClinVar,saturation_mutlist",1364128,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.32806,0.3442060351371765,-0.10136,-0.1087178432905822,-0.21471,-0.2183889216452911,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.018,,,Uncertain,,Uncertain,,,Uncertain,81.7,,False,81.7,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,96.55,-,-0.2213,1.6112,-22.2332,-5.07098975814963,0.0085550212982532,Benign,0.1443,benign,-3.644,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L264A,NP_000537:p.Leu264Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.00938,1.4711352586746216,2.44354,1.7161406062025366,2.2264600000000003,1.8627603031012683,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.67,E,-0.3237,1.041,-22.2273,-5.24287573150059,0.6821823319582183,Pathogenic,0.8098,pathogenic,-3.996,available,https://doi.org/10.1101/2022.10.22.513328 +L264C,NP_000537:p.Leu264Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.6418,0.6221842765808105,1.91565,2.085379750960356,1.7787250000000001,1.863589875480178,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.67,E,-0.3129,1.041,-22.2273,-4.36502341035108,0.2538362157130683,Benign,0.7742,pathogenic,-3.728,available,https://doi.org/10.1101/2022.10.22.513328 +L264D,NP_000537:p.Leu264Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.08195,1.7354625463485718,2.21054,2.3129319196524314,2.146245,2.1974409598262157,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.67,E,-0.4452,1.041,-22.2273,-5.4905070548635,0.2408600521336015,Benign,0.9863,pathogenic,-4.22,available,https://doi.org/10.1101/2022.10.22.513328 +L264E,NP_000537:p.Leu264Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.48565,1.2118911743164062,1.59626,1.7314553056751192,1.5409549999999999,1.6085526528375595,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.67,E,-0.4133,1.041,-22.2273,-5.2808123547975,0.2853288435570334,Benign,0.9408,pathogenic,-4.059,available,https://doi.org/10.1101/2022.10.22.513328 +L264F,NP_000537:p.Leu264Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.20542,0.9283725023269652,1.68503,0.9834705274910108,1.445225,1.0944452637455053,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.67,E,-0.2571,1.041,-22.2273,-6.5461871813981,0.7852998097224846,Pathogenic,0.7496,pathogenic,-4.215,available,https://doi.org/10.1101/2022.10.22.513328 +L264G,NP_000537:p.Leu264Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.38715,2.275953531265259,3.70238,3.0230588163483,3.044765,2.70510440817415,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.67,E,-0.3985,1.041,-22.2273,-6.5461871813981,0.8297180068720659,Pathogenic,0.9577,pathogenic,-4.449,available,https://doi.org/10.1101/2022.10.22.513328 +L264H,NP_000537:p.Leu264His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.20367,1.7076363563537598,1.95952,1.5346897951000975,2.081595,1.8691798975500487,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.67,E,-0.366,1.041,-22.2273,-6.5461871813981,0.6636074140855083,Uncertain,0.9052,pathogenic,-4.158,available,https://doi.org/10.1101/2022.10.22.513328 +L264I,NP_000537:p.Leu264Ile,"hg19,17:g.7577148G>T, hg38,17:g.7673830G>T",,,0.378,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",640121,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.57743,-0.2350059747695922,0.87415,0.297898969709503,0.7257899999999999,0.4376644848547515,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.67,E,-0.1181,1.041,-6.6176,-1.87427155223024,0.0002595743008387,Benign,0.1043,benign,-3.25,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L264K,NP_000537:p.Leu264Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.60868,1.572554588317871,2.59252,1.9468027368578085,2.1006,1.7777413684289043,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.67,E,-0.4123,1.041,-22.2273,-6.5461871813981,0.7892828327528014,Pathogenic,0.9339,pathogenic,-4.334,available,https://doi.org/10.1101/2022.10.22.513328 +L264M,NP_000537:p.Leu264Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.20079,0.5617212057113647,1.61497,0.76942443391914,0.90788,0.48510721695957,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.67,E,-0.1482,1.041,-7.9395,-1.71456015363385,0.3599754373194359,Uncertain,0.2687,benign,-3.73,available,https://doi.org/10.1101/2022.10.22.513328 +L264N,NP_000537:p.Leu264Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.27821,1.9145081043243408,2.38435,1.6660965169625923,2.33128,1.9721532584812962,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.67,E,-0.3915,1.041,-22.2273,-5.75837237714931,0.8481105964048743,Pathogenic,0.9085,pathogenic,-4.354,available,https://doi.org/10.1101/2022.10.22.513328 +L264P,NP_000537:p.Leu264Pro,"hg19,17:g.7577147A>G, hg38,17:g.7673829A>G",,,0.831,"COSMIC,ClinVar,saturation_mutlist",480759,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.41825,1.425531983375549,1.98401,3.193610937111881,1.70113,2.3059304685559407,Neutral,Uncertain,Uncertain,Neutral,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.67,E,-0.3312,1.041,-7.3546,-3.41572466550931,0.2349656202404051,Benign,0.8569,pathogenic,-3.679,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L264Q,NP_000537:p.Leu264Gln,"hg38,17:g.7673829A>T",,,0.813,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.75206,1.3173537254333496,1.47347,1.5567595131013434,1.612765,1.6544097565506717,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.67,E,-0.3444,1.041,-22.2273,-5.75837237714931,0.8582935796690372,Pathogenic,0.8352,pathogenic,-4.15,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L264R,NP_000537:p.Leu264Arg,"hg19,17:g.7577147A>C, hg19,17:g.7673829A>C, hg38,17:g.7673829A>C",,,0.822,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.81292,1.8692338466644287,2.79694,1.7044107552699388,2.30493,1.7586653776349694,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.67,E,-0.4039,1.041,-22.2273,-6.5461871813981,0.7901559440941178,Pathogenic,0.8804,pathogenic,-4.239,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L264S,NP_000537:p.Leu264Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.30542,1.6197218894958496,2.80238,2.491298735592242,2.5538999999999996,2.398359367796121,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.67,E,-0.3541,1.041,-22.2273,-5.24287573150059,0.7432071545088421,Pathogenic,0.917,pathogenic,-4.077,available,https://doi.org/10.1101/2022.10.22.513328 +L264T,NP_000537:p.Leu264Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.37448,0.9159963130950928,1.69558,1.729746038669393,1.53503,1.5521130193346964,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.67,E,-0.259,1.041,-8.9394,-3.82161584058167,0.0819531147275861,Benign,0.583,pathogenic,-3.621,available,https://doi.org/10.1101/2022.10.22.513328 +L264V,NP_000537:p.Leu264Val,"hg19,17:g.7577148G>C, hg38,17:g.7673830G>C",,,0.381,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.32662,-0.0456994771957397,1.16463,0.5095900300529612,1.245625,0.9181050150264806,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,97.67,E,-0.1233,1.041,-0.5217,-0.402437184412507,3.577275405634069e-07,Benign,0.0848,benign,-2.988,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L264W,NP_000537:p.Leu264Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.47537,1.1753671169281006,2.08401,0.8127420861132753,1.77969,1.1440560430566378,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.67,E,-0.3563,1.041,-22.2273,-6.5461871813981,0.8021018762609149,Pathogenic,0.9282,pathogenic,-4.365,available,https://doi.org/10.1101/2022.10.22.513328 +L264Y,NP_000537:p.Leu264Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.29987,1.3864470720291138,1.75986,1.3057149090106936,1.529865,1.3027924545053469,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.033,,,Uncertain,,Uncertain,,,Uncertain,31.9,,False,31.9,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.67,E,-0.3492,1.041,-22.2273,-6.5461871813981,0.8052134654630674,Pathogenic,0.9439,pathogenic,-4.32,available,https://doi.org/10.1101/2022.10.22.513328 +L265A,NP_000537:p.Leu265Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.19671,2.294877052307129,2.91565,2.1672976028236994,2.55618,2.1820038014118497,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.11,E,-0.4156,0.0422,-22.2332,-7.34723861280443,0.8707259869926334,Pathogenic,0.8985,pathogenic,-4.486,available,https://doi.org/10.1101/2022.10.22.513328 +L265C,NP_000537:p.Leu265Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.28648,1.5241713523864746,2.34354,2.450667262514137,2.31501,2.3685736312570684,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.11,E,-0.4048,0.0422,-22.2332,-7.34723861280443,0.7752014848127868,Pathogenic,0.9147,pathogenic,-4.28,available,https://doi.org/10.1101/2022.10.22.513328 +L265D,NP_000537:p.Leu265Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.06417,2.339888095855713,3.7381,2.8638546862431618,3.401135,2.964012343121581,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.11,E,-0.5371,0.0422,-22.2332,-7.87558311971445,0.860964696318212,Pathogenic,0.9979,pathogenic,-4.85,available,https://doi.org/10.1101/2022.10.22.513328 +L265E,NP_000537:p.Leu265Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.64446,2.447261571884156,4.68231,2.252762403844301,3.663385,2.4486112019221506,Uncertain,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.11,E,-0.5052,0.0422,-22.2332,-7.87558311971445,0.8589987811206987,Pathogenic,0.9814,pathogenic,-4.684,available,https://doi.org/10.1101/2022.10.22.513328 +L265F,NP_000537:p.Leu265Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.47904,1.6942508220672607,3.85714,0.6824472633644731,2.16809,0.5807436316822365,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.11,E,-0.3491,0.0422,-22.2332,-6.34314312364686,0.7726812077242147,Pathogenic,0.6692,pathogenic,-4.072,available,https://doi.org/10.1101/2022.10.22.513328 +L265G,NP_000537:p.Leu265Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.1439,3.040003538131714,4.8415,3.7011645802801656,3.9927,3.422532290140083,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.11,E,-0.4904,0.0422,-22.2332,-7.87558311971445,0.8517707979603193,Pathogenic,0.9901,pathogenic,-4.767,available,https://doi.org/10.1101/2022.10.22.513328 +L265H,NP_000537:p.Leu265His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.17418,2.418719291687012,2.60374,1.5689073816822958,2.38896,1.8715436908411478,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.11,E,-0.458,0.0422,-22.2332,-6.61671431671546,0.590477952725514,Uncertain,0.9292,pathogenic,-4.209,available,https://doi.org/10.1101/2022.10.22.513328 +L265I,NP_000537:p.Leu265Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.28107,1.0951430797576904,1.41156,0.8915304655291129,1.346315,1.0863002327645563,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.11,E,-0.2219,0.0422,-8.9453,-3.83204599167508,0.0687300349208046,Benign,0.2627,benign,-3.624,available,https://doi.org/10.1101/2022.10.22.513328 +L265K,NP_000537:p.Leu265Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.19848,2.2747724056243896,3.07721,2.28886124356852,2.137845,1.74367062178426,Uncertain,Uncertain,Destabilizing,Uncertain,Neutral,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.11,E,-0.5042,0.0422,-22.2332,-7.61141086625944,0.8702665156745051,Pathogenic,0.9454,pathogenic,-4.58,available,https://doi.org/10.1101/2022.10.22.513328 +L265M,NP_000537:p.Leu265Met,"hg38,17:g.7673827G>T",,,0.870,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.24978,1.0033842325210571,1.73095,1.0033069547342912,0.9903649999999999,0.6265434773671457,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.11,E,-0.313,0.0422,-22.2332,-3.91495728915611,0.7528596764569417,Pathogenic,0.4348,ambiguous,-3.942,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L265N,NP_000537:p.Leu265Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.68309,2.548973798751831,3.04218,2.10606301829212,2.862635,2.3945765091460602,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.11,E,-0.4834,0.0422,-22.2332,-7.87558311971445,0.8671597521678513,Pathogenic,0.9905,pathogenic,-4.724,available,https://doi.org/10.1101/2022.10.22.513328 +L265P,NP_000537:p.Leu265Pro,"hg19,17:g.7577143_7577144delinsAG, hg19,17:g.7577144A>G, hg19,17:g.7673826A>G, hg38,17:g.7673825_7673826delinsAG, hg38,17:g.7673826A>G",,,0.948,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",245777,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.41896,2.6842665672302246,7.77415,6.431474863589326,6.596555,5.925217431794663,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.11,E,-0.499,0.0422,-22.2332,-7.87558311971445,0.8656403829284776,Pathogenic,0.9913,pathogenic,-4.572,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L265Q,NP_000537:p.Leu265Gln,"hg19,17:g.7577144A>T, hg19,17:g.7673826A>T, hg38,17:g.7673826A>T",,,0.964,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",953467,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.31004,2.3107078075408936,2.95306,1.824464033223944,2.13155,1.567252016611972,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.11,E,-0.4364,0.0422,-22.2332,-7.87558311971445,0.8682348257349046,Pathogenic,0.9105,pathogenic,-4.315,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L265R,NP_000537:p.Leu265Arg,"hg19,17:g.7577144A>C, hg19,17:g.7673826A>C, hg38,17:g.7673826A>C",,,0.965,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2764543,Uncertain significance,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.39231,2.271669149398804,2.76565,1.8499693745922463,2.07898,1.621139687296123,Uncertain,Neutral,Destabilizing,Uncertain,Neutral,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.11,E,-0.4958,0.0422,-22.2332,-7.37297889237968,0.8695697876898334,Pathogenic,0.8691,pathogenic,-4.334,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L265S,NP_000537:p.Leu265Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.12871,2.508329629898072,3.81429,3.016128476766552,3.4715,3.072419238383276,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.11,E,-0.446,0.0422,-22.2332,-6.75359307517743,0.8708271923916435,Pathogenic,0.981,pathogenic,-4.464,available,https://doi.org/10.1101/2022.10.22.513328 +L265T,NP_000537:p.Leu265Thr,"hg19,17:g.7577144_7577145delinsGT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.25283,2.3218436241149902,2.6483,2.3401434883924948,2.950565,2.7964867441962475,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.11,E,-0.4187,0.0422,-22.2332,-7.34723861280443,0.8694242445775713,Pathogenic,0.9283,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L265V,NP_000537:p.Leu265Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.82238,1.650857925415039,1.58503,1.3488569289618082,1.703705,1.5856184644809042,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.11,E,-0.2582,0.0422,-8.9453,-3.77375082373062,0.1106420172817101,Benign,0.3252,benign,-3.641,available,https://doi.org/10.1101/2022.10.22.513328 +L265W,NP_000537:p.Leu265Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.68495,1.89826762676239,3.9619,0.7480298003196619,3.3234250000000003,1.716489900159831,Uncertain,Uncertain,Uncertain,Destabilizing,Neutral,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.11,E,-0.4482,0.0422,-22.2332,-6.84349102707037,0.8235872876217347,Pathogenic,0.8178,pathogenic,-4.396,available,https://doi.org/10.1101/2022.10.22.513328 +L265Y,NP_000537:p.Leu265Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.70158,1.9945476055145264,4.89354,0.9944619909677036,2.79756,0.8480209954838518,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.056,,,,,,,,,22.6,,False,22.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.11,E,-0.4411,0.0422,-22.2332,-5.86744239818955,0.6527592081560019,Uncertain,0.8938,pathogenic,-4.002,available,https://doi.org/10.1101/2022.10.22.513328 +G266A,NP_000537:p.Gly266Ala,"hg19,17:g.7577141C>G, hg38,17:g.7673823C>G",,,0.960,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.22463,1.537602424621582,1.73537,-0.5092948613442427,1.98,0.8576675693278786,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.31,0.0633,-8.9453,-6.36324581472309,0.012636196124792,Benign,0.8482,pathogenic,-3.668,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266C,NP_000537:p.Gly266Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.49845,1.5609409809112549,5.26224,0.7426179727644524,5.880345,3.620533986382226,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4376,0.0633,-22.2332,-6.93805310884829,0.8691672870950153,Pathogenic,0.9857,pathogenic,-4.429,available,https://doi.org/10.1101/2022.10.22.513328 +G266D,NP_000537:p.Gly266Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,14.54746,2.470654964447021,8.68673,2.045187099026128,11.617094999999999,8.296323549513064,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4381,0.0633,-22.2332,-6.77792298967897,0.804870665107659,Pathogenic,0.9976,pathogenic,-4.211,available,https://doi.org/10.1101/2022.10.22.513328 +G266E,NP_000537:p.Gly266Glu,"hg19,17:g.7577141C>T, hg19,17:g.7673823C>T, hg38,17:g.7673823C>T",,,0.973,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",161516,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier II - Potential,1,P53 DNA-binding domain (PF00870),2.60.40.720,15.3311,2.471712589263916,15.33946,2.6582360234264613,15.335280000000001,8.99466801171323,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.3696,0.0633,-8.9453,-7.46706303705164,0.8706355278571457,Pathogenic,0.9988,pathogenic,-4.432,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266F,NP_000537:p.Gly266Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,29.36946,1.4223839044570925,6.47687,2.0785658177955684,17.923165,15.724012908897784,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4757,0.0633,-22.2332,-7.88629348640739,0.8701221009629496,Pathogenic,0.9979,pathogenic,-4.817,available,https://doi.org/10.1101/2022.10.22.513328 +G266H,NP_000537:p.Gly266His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,24.1813,2.100362777709961,7.86531,2.0768372968151194,16.023305,13.12906864840756,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4504,0.0633,-22.2332,-7.88629348640739,0.8708218989973193,Pathogenic,0.9995,pathogenic,-4.688,available,https://doi.org/10.1101/2022.10.22.513328 +G266I,NP_000537:p.Gly266Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,16.2567,1.8413585424423216,11.83367,2.4541312790758387,14.045185,9.355415639537918,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.5213,0.0633,-22.2332,-7.88629348640739,0.8707945277384153,Pathogenic,0.9983,pathogenic,-4.824,available,https://doi.org/10.1101/2022.10.22.513328 +G266K,NP_000537:p.Gly266Lys,"hg19,17:g.7577141_7577142delinsTT, hg38,17:g.7673823_7673824delinsTT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,18.87678,2.3497610092163086,17.7619,3.690275894982849,18.31934,11.283527947491425,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4703,0.0633,-22.2332,-7.88629348640739,0.8707875146213229,Pathogenic,0.9995,pathogenic,-4.696,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266L,NP_000537:p.Gly266Leu,"hg38,17:g.7673823_7673824delinsAA",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,15.93032,1.935988187789917,14.44252,1.6831562682303924,15.18642,8.806738134115196,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4896,0.0633,-22.2332,-7.88629348640739,0.8706234257673205,Pathogenic,0.9963,pathogenic,-4.708,available,https://doi.org/10.1101/2022.10.22.513328 +G266M,NP_000537:p.Gly266Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.72816,1.815470576286316,7.24966,1.5525164216799985,9.98891,7.1403382108399995,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4278,0.0633,-22.2332,-7.88629348640739,0.8708636637510747,Pathogenic,0.9989,pathogenic,-4.8,available,https://doi.org/10.1101/2022.10.22.513328 +G266N,NP_000537:p.Gly266Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.52568,2.36597204208374,8.40272,1.3510692003049198,10.9642,7.43837460015246,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4384,0.0633,-22.2332,-7.46706303705164,0.8705798072697052,Pathogenic,0.9992,pathogenic,-4.65,available,https://doi.org/10.1101/2022.10.22.513328 +G266P,NP_000537:p.Gly266Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.54087,2.0135929584503174,16.78197,6.170936959746607,12.66142,7.355903479873303,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4677,0.0633,-8.9453,-7.88629348640739,0.8699137131956447,Pathogenic,0.9995,pathogenic,-4.68,available,https://doi.org/10.1101/2022.10.22.513328 +G266Q,NP_000537:p.Gly266Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,15.90796,2.3030378818511963,9.99252,2.061673518845969,12.95024,8.984816759422984,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4413,0.0633,-22.2332,-7.46706303705164,0.8678472978241196,Pathogenic,0.9987,pathogenic,-4.703,available,https://doi.org/10.1101/2022.10.22.513328 +G266R,NP_000537:p.Gly266Arg,"hg19,17:g.7577142C>G, hg19,17:g.7577142C>T, hg19,17:g.7577142_7577143delinsTT, hg19,17:g.7673824C>G, hg19,17:g.7673824C>T, hg38,17:g.7673824C>G, hg38,17:g.7673824C>T, hg38,17:g.7673824_7673825delinsTT",,,0.963,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","458566, 376605","Pathogenic, Pathogenic","2, 2",Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,22.55904,2.0885229110717773,16.5,2.724237305125748,19.529519999999998,12.641638652562873,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4544,0.0633,-22.2332,-7.88629348640739,0.8585408758137115,Pathogenic,0.9986,pathogenic,-4.518,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266S,NP_000537:p.Gly266Ser,,,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.27763,1.991459369659424,3.67075,0.5795920304617255,3.97419,2.428611015230863,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.3837,0.0633,-22.2332,-6.93805310884829,0.8684281199810319,Pathogenic,0.9729,pathogenic,-4.17,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266T,NP_000537:p.Gly266Thr,"hg19,17:g.7577141_7577142delinsGT, hg38,17:g.7673823_7673824delinsGT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,11.322,2.124535322189331,7.20136,1.2330964766379242,9.26168,6.277548238318961,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4606,0.0633,-22.2332,-6.93805310884829,0.8675692223173517,Pathogenic,0.9969,pathogenic,-4.639,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266V,NP_000537:p.Gly266Val,"hg19,17:g.7577141C>A, hg19,17:g.7673823C>A, hg38,17:g.7673823C>A",,0.0,0.974,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",233303,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.71788,1.7885537147521973,9.77517,1.4701596421049925,11.746524999999998,7.594019821052496,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4646,0.0633,-22.2332,-7.88629348640739,0.8707030325359331,Pathogenic,0.9956,pathogenic,-4.654,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G266W,NP_000537:p.Gly266Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,40.56338,1.525638222694397,12.36565,2.42668265261908,26.464515000000002,21.49503132630954,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4754,0.0633,-22.2332,-7.88629348640739,0.8586158067431862,Pathogenic,0.9978,pathogenic,-4.717,available,https://doi.org/10.1101/2022.10.22.513328 +G266Y,NP_000537:p.Gly266Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,33.2279,1.5389347076416016,9.90646,2.595492340407076,21.56718,17.911696170203538,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.041,,,,,,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.99,E,-0.4761,0.0633,-22.2332,-7.88629348640739,0.8705950513473898,Pathogenic,0.9981,pathogenic,-4.773,available,https://doi.org/10.1101/2022.10.22.513328 +R267A,NP_000537:p.Arg267Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.76377,1.520417094230652,0.54864,1.7443117447073535,0.6562049999999999,1.2540408723536767,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.3984,0.1239,-22.2332,-7.70598599850712,0.763277557069098,Pathogenic,0.9968,pathogenic,-4.405,available,https://doi.org/10.1101/2022.10.22.513328 +R267C,NP_000537:p.Arg267Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.41392,1.2601721286773682,0.70102,2.432222595136844,0.55747,1.423071297568422,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.4073,0.1239,-22.2332,-7.70598599850712,0.7270433074700877,Pathogenic,0.9269,pathogenic,-4.082,available,https://doi.org/10.1101/2022.10.22.513328 +R267D,NP_000537:p.Arg267Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.25301,2.627232551574707,3.67007,3.530963831230409,3.4615400000000003,3.3919869156152043,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.4895,0.1239,-22.2332,-7.03787472762136,0.8122861587131511,Pathogenic,0.9988,pathogenic,-4.59,available,https://doi.org/10.1101/2022.10.22.513328 +R267E,NP_000537:p.Arg267Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.25323,2.074803352355957,1.89728,2.510333022846696,2.075255,2.381781511423348,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.4347,0.1239,-22.2332,-7.03787472762136,0.7954748457581995,Pathogenic,0.9861,pathogenic,-4.448,available,https://doi.org/10.1101/2022.10.22.513328 +R267F,NP_000537:p.Arg267Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.47664,0.7216299772262573,4.7568,1.413236815265776,3.61672,1.944938407632888,Uncertain,Uncertain,Neutral,Destabilizing,Neutral,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.4306,0.1239,-22.2332,-6.77941400693417,0.7268613507697419,Pathogenic,0.9982,pathogenic,-4.458,available,https://doi.org/10.1101/2022.10.22.513328 +R267G,NP_000537:p.Arg267Gly,"hg19,17:g.7577139G>C, hg19,17:g.7673821G>C, hg38,17:g.7673821G>C",,,0.946,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1761541,Pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.97136,2.126530647277832,2.49456,3.6988755822338,2.23296,2.8351177911169,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.4338,0.1239,-22.2332,-7.70598599850712,0.7307094535702936,Pathogenic,0.9913,pathogenic,-4.378,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R267H,NP_000537:p.Arg267His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.95433,1.7698919773101809,1.49116,1.889845962342999,2.722745,2.9220879811714995,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.2885,0.1239,-6.6235,-3.9168867483715,0.0011584855650976,Benign,0.928,pathogenic,-3.609,available,https://doi.org/10.1101/2022.10.22.513328 +R267I,NP_000537:p.Arg267Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.45067,0.875190258026123,0.9398,1.0749629224772663,0.24456499999999998,0.31214646123863315,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.4279,0.1239,-22.2332,-7.44752527781993,0.4627388881602232,Uncertain,0.9929,pathogenic,-4.459,available,https://doi.org/10.1101/2022.10.22.513328 +R267K,NP_000537:p.Arg267Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.48739,0.5848349332809448,1.47891,1.8401651083041968,0.49576,0.6763875541520984,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.54,E,-0.2887,0.1239,-22.2332,-3.78185491236608,0.6437276333224374,Uncertain,0.9118,pathogenic,-3.914,available,https://doi.org/10.1101/2022.10.22.513328 +R267L,NP_000537:p.Arg267Leu,"hg19,17:g.7577137_7577138delinsAA, hg19,17:g.7577138C>A, hg19,17:g.7673820C>A, hg38,17:g.7673819_7673820delinsAA, hg38,17:g.7673820C>A",,,0.911,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",852206,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.49447,0.9069818258285522,-0.27959,0.7550702884989313,-0.88703,-0.3696998557505343,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.4009,0.1239,-22.2332,-4.27853092395634,0.7874690055118875,Pathogenic,0.9887,pathogenic,-4.313,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R267M,NP_000537:p.Arg267Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.31866,0.8688325881958008,-0.45646,1.1642271990613862,-0.8875599999999999,-0.07721640046930689,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.3667,0.1239,-22.2332,-7.44752527781993,0.8148616754695868,Pathogenic,0.9967,pathogenic,-4.406,available,https://doi.org/10.1101/2022.10.22.513328 +R267N,NP_000537:p.Arg267Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.49296,2.093099594116211,0.82823,2.12659225258484,1.160595,1.8097761262924201,Neutral,Uncertain,Destabilizing,Neutral,Neutral,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.4133,0.1239,-22.2332,-7.03787472762136,0.7864307798303529,Pathogenic,0.9977,pathogenic,-4.465,available,https://doi.org/10.1101/2022.10.22.513328 +R267P,NP_000537:p.Arg267Pro,"hg19,17:g.7577137_7577138delinsGG, hg19,17:g.7577138C>G, hg19,17:g.7673820C>G, hg38,17:g.7673819_7673820inv, hg38,17:g.7673820C>G",,,0.927,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428867,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.90939,1.9886075258255005,8.4017,6.801358927609924,6.655545,5.855374463804962,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.5405,0.1239,-22.2332,-7.70598599850712,0.7564408251132462,Pathogenic,0.9992,pathogenic,-4.476,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R267Q,NP_000537:p.Arg267Gln,"hg19,17:g.7577138C>T, hg19,17:g.7673820C>T, hg38,17:g.7673820C>T",,1.2030991835e-05,0.902,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127823,Likely pathogenic,3,Uncertain significance,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.12121,1.4041035175323486,-0.11088,1.807951657941256,0.005164999999999996,0.964580828970628,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.3732,0.1239,-22.2332,-5.21833867213814,0.0337001581496403,Benign,0.8812,pathogenic,-3.678,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R267S,NP_000537:p.Arg267Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.74494,1.4517624378204346,1.39218,2.7018892770040885,1.06856,1.7234146385020443,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.3312,0.1239,-8.9453,-7.70598599850712,0.0660430118803936,Benign,0.9972,pathogenic,-3.915,available,https://doi.org/10.1101/2022.10.22.513328 +R267T,NP_000537:p.Arg267Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.10485,1.095550298690796,1.16327,1.9384765396485744,0.52921,0.9168132698242872,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.4033,0.1239,-22.2332,-7.70598599850712,0.8209365269197904,Pathogenic,0.9958,pathogenic,-4.21,available,https://doi.org/10.1101/2022.10.22.513328 +R267V,NP_000537:p.Arg267Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.11845,0.8749996423721313,0.9068,1.0794530996551337,0.512625,0.5989515498275668,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.54,E,-0.4149,0.1239,-22.2332,-7.44752527781993,0.7674434817242352,Pathogenic,0.9923,pathogenic,-4.338,available,https://doi.org/10.1101/2022.10.22.513328 +R267W,NP_000537:p.Arg267Trp,"hg19,17:g.7577139G>A, hg19,17:g.7673821G>A, hg38,17:g.7673821G>A",,0.0,0.917,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141764,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,5.12564,1.056020736694336,1.74762,1.1997649876942111,3.43663,3.1627024938471053,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.3484,0.1239,-8.9453,-6.77941400693417,0.8457833383937833,Pathogenic,0.9682,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R267Y,NP_000537:p.Arg267Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.13525,1.189610242843628,5.8585,1.6375994511570862,5.996875,3.886424725578543,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.017,,,,,,,,,17.8,,True,17.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.54,E,-0.4199,0.1239,-22.2332,-6.77941400693417,0.8028177108850432,Pathogenic,0.992,pathogenic,-4.466,available,https://doi.org/10.1101/2022.10.22.513328 +N268A,NP_000537:p.Asn268Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.73649,0.433249294757843,0.04218,-0.0098308442091493,0.389335,0.36332957789542536,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.08,E,-0.2294,1.0811,-22.2302,-4.36168635290202,0.0014197097158054,Benign,0.2255,benign,-3.398,available,https://doi.org/10.1101/2022.10.22.513328 +N268C,NP_000537:p.Asn268Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.23595,-0.2615457773208618,0.85,0.7667283209730238,0.542975,0.5013391604865118,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.08,E,-0.2013,1.0811,-6.9425,-2.41546047797844,1.4763222772045958e-07,Benign,0.1827,benign,-3.144,available,https://doi.org/10.1101/2022.10.22.513328 +N268D,NP_000537:p.Asn268Asp,"hg19,17:g.7577136T>C",,,0.221,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.3454,-0.4623206853866577,-0.89762,1.0714647244844704,-0.62151,0.36303236224223523,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.08,E,-0.1471,1.0811,-5.4831,-0.591323006675345,1.0104557927148332e-06,Benign,0.0926,benign,-3.234,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N268E,NP_000537:p.Asn268Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.97925,0.7406960129737854,0.44694,0.6709467376696104,0.713095,0.8250983688348053,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.08,E,-0.2597,1.0811,-22.2302,-4.29554783337864,0.0356002993987211,Benign,0.3838,ambiguous,-3.608,available,https://doi.org/10.1101/2022.10.22.513328 +N268F,NP_000537:p.Asn268Phe,"hg38,17:g.7673817_7673818inv",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.73663,0.6315391659736633,-0.31156,-0.9652157225881908,0.212535,-0.11429286129409538,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.08,E,-0.2865,1.0811,-22.2302,-4.50942508843303,4.991052092879287e-05,Benign,0.6464,pathogenic,-3.554,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N268G,NP_000537:p.Asn268Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.6608,0.2738651037216186,1.23333,1.811481647899621,1.447065,1.7361408239498104,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.08,E,-0.1843,1.0811,-7.3575,-2.0612816299312,1.3988411064962723e-09,Benign,0.2289,benign,-3.188,available,https://doi.org/10.1101/2022.10.22.513328 +N268H,NP_000537:p.Asn268His,"hg38,17:g.7673818T>G",,,0.404,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.7775,0.6675941944122314,0.45646,-0.344622891460799,0.61698,0.21643855426960049,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.08,E,-0.2344,1.0811,-22.2302,-5.51296298197219,0.0004566673940268,Benign,0.1252,benign,-3.34,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N268I,NP_000537:p.Asn268Ile,"hg19,17:g.7577135T>A, hg19,17:g.7673817T>A, hg38,17:g.7673817T>A",,,0.511,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.54611,1.20530903339386,2.49796,-0.1569998667835959,2.022035,0.6945550666082021,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.08,E,-0.2796,1.0811,-22.2302,-5.43571068450721,0.0068861243844721,Benign,0.4467,ambiguous,-3.855,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N268K,NP_000537:p.Asn268Lys,"hg19,17:g.7577134G>C, hg38,17:g.7673816G>C",,,0.344,"COSMIC,ClinVar,saturation_mutlist",1349719,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.2059,1.2441127300262451,1.3568,0.6924737534617811,1.28135,0.9491868767308905,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.08,E,-0.2326,1.0811,-22.2302,-2.67496267781037,0.0002191671813352,Benign,0.3993,ambiguous,-3.11,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N268L,NP_000537:p.Asn268Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.96498,0.8367996215820312,0.84898,-1.0005446768177306,0.9069799999999999,-0.01778233840886534,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.08,E,-0.2861,1.0811,-22.2302,-4.74099025714108,0.0001783843333275,Benign,0.4293,ambiguous,-3.613,available,https://doi.org/10.1101/2022.10.22.513328 +N268M,NP_000537:p.Asn268Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.13373,0.4307804703712463,0.39932,-0.5644192952591559,0.132795,-0.34907464762957796,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.08,E,-0.1673,1.0811,-7.9424,-3.47104308394239,0.0023884216399632,Benign,0.4677,ambiguous,-3.586,available,https://doi.org/10.1101/2022.10.22.513328 +N268P,NP_000537:p.Asn268Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.76788,2.6259093284606934,5.46667,8.034213052670903,4.117274999999999,5.401046526335452,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.08,E,-0.395,1.0811,-22.2302,-6.37323766412879,0.0528643165791038,Benign,0.9645,pathogenic,-3.827,available,https://doi.org/10.1101/2022.10.22.513328 +N268Q,NP_000537:p.Asn268Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.79226,0.4501014351844787,0.08299,0.1789234049954724,0.437625,0.4855917024977362,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.08,E,-0.1453,1.0811,-6.9425,-2.43363401844085,1.395131926512854e-08,Benign,0.3103,benign,-3.058,available,https://doi.org/10.1101/2022.10.22.513328 +N268R,NP_000537:p.Asn268Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.15164,1.2782673835754397,1.40306,-0.2493415314923858,1.27735,0.4511492342538071,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.08,E,-0.1531,1.0811,-0.3501,-0.33024769470899,1.1724704115149305e-12,Benign,0.355,ambiguous,-2.726,available,https://doi.org/10.1101/2022.10.22.513328 +N268S,NP_000537:p.Asn268Ser,"hg19,17:g.7577135T>C, hg38,17:g.7673817T>C",,,0.327,"COSMIC,ClinVar,saturation_mutlist",2831391,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.67909,-0.1651636362075805,0.87109,1.2541258961088526,0.7750900000000001,0.9666079480544263,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.08,E,-0.1183,1.0811,-6.3575,-1.14138344287833,1.8746849181159628e-06,Benign,0.0787,benign,-3.146,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N268T,NP_000537:p.Asn268Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.57647,0.7865332365036011,1.09966,0.7187919227230823,1.338065,1.1476309613615412,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.08,E,-0.2489,1.0811,-22.2302,-4.88317032886151,0.0145796015062153,Benign,0.1962,benign,-3.526,available,https://doi.org/10.1101/2022.10.22.513328 +N268V,NP_000537:p.Asn268Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.57305,0.9977946281433104,0.59728,-0.1061151968955609,0.5851649999999999,0.2334674015522195,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.08,E,-0.273,1.0811,-22.2302,-5.43571068450721,0.0160592414790959,Benign,0.3892,ambiguous,-3.679,available,https://doi.org/10.1101/2022.10.22.513328 +N268W,NP_000537:p.Asn268Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.07727,0.2448217868804931,-0.44184,-1.039006668444962,0.31771499999999997,0.019131665777519014,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.08,E,-0.2916,1.0811,-22.2302,-5.51296298197219,0.023095716275161,Benign,0.766,pathogenic,-3.95,available,https://doi.org/10.1101/2022.10.22.513328 +N268Y,NP_000537:p.Asn268Tyr,"hg19,17:g.7577136T>A, hg38,17:g.7673818T>A",,,0.561,"cBioPortal,ClinVar,saturation_mutlist",827405,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.18455,0.9902868270874025,-0.16259,-0.5753838376280695,0.51098,0.3045830811859652,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.019,,,,,,,,,23.7,,True,23.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.08,E,-0.2701,1.0811,-22.2302,-5.04988168903457,0.0013933634097833,Benign,0.2266,benign,-3.712,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269A,NP_000537:p.Ser269Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.07626,-0.0510696768760681,-0.26837,-0.1380062036892188,-0.672315,-0.6071331018446093,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,-,uncertain,neutral,False,neutral,neutral,98.0,E,-0.1798,1.0942,-22.2302,-2.72864476397273,0.2876327388859218,Benign,0.1426,benign,-3.555,available,https://doi.org/10.1101/2022.10.22.513328 +S269C,NP_000537:p.Ser269Cys,"hg19,17:g.7577133T>A, hg38,17:g.7673815T>A",,,0.460,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2575177,Benign,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.10838,-0.4820830821990967,0.50714,0.1852436255375911,-0.30061999999999994,-0.4615681872312044,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.1209,1.0942,-0.803,-1.55477986731131,4.765649891038397e-08,Benign,0.0938,benign,-3.03,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269D,NP_000537:p.Ser269Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.32375,1.804098010063172,1.70476,1.1245392203506477,1.514255,1.224144610175324,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.2784,1.0942,-22.2302,-5.91168618561201,0.8637109441364133,Pathogenic,0.9234,pathogenic,-4.334,available,https://doi.org/10.1101/2022.10.22.513328 +S269E,NP_000537:p.Ser269Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.54946,0.6532825827598572,2.17007,1.2993193007503234,1.359765,0.9243896503751616,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.2516,1.0942,-22.2302,-5.91168618561201,0.6869341144660784,Pathogenic,0.9531,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328 +S269F,NP_000537:p.Ser269Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.03683,-0.6953525543212891,-0.49932,-0.8306052883944609,-0.23124499999999998,-0.39688764419723044,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.2578,1.0942,-22.2302,-5.58557411384376,0.6495342530027585,Uncertain,0.7539,pathogenic,-4.022,available,https://doi.org/10.1101/2022.10.22.513328 +S269G,NP_000537:p.Ser269Gly,"hg19,17:g.7577133T>C, hg38,17:g.7673815T>C",,,0.688,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.24916,1.0658913850784302,0.96259,1.343843011565562,0.6058749999999999,0.796501505782781,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,DOWN,destabilizing,neutral,False,neutral,neutral,98.0,E,-0.1889,1.0942,-22.2302,-6.11743999468942,0.7232675333413295,Pathogenic,0.2576,benign,-3.992,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269H,NP_000537:p.Ser269His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.83247,0.1143037676811218,0.44286,-0.2855503825441963,0.637665,0.2734598087279019,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.259,1.0942,-22.2302,-5.58557411384376,0.8567273299230327,Pathogenic,0.7788,pathogenic,-4.179,available,https://doi.org/10.1101/2022.10.22.513328 +S269I,NP_000537:p.Ser269Ile,"hg19,17:g.7577132C>A, hg38,17:g.7673814C>A",,,0.810,"COSMIC,ClinVar,saturation_mutlist",2575169,Likely pathogenic,0,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.01768,-0.1041979789733886,1.47551,0.1294068085507593,1.2465950000000001,0.5735434042753796,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.261,1.0942,-22.2302,-3.98265316785276,0.2235202932537445,Benign,0.4663,ambiguous,-3.882,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269K,NP_000537:p.Ser269Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.86041,0.6187564730644226,2.15986,1.0537814804205603,0.6497250000000001,0.09668574021028015,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.2684,1.0942,-22.2302,-4.36669348320052,0.1741881079372422,Benign,0.9767,pathogenic,-3.919,available,https://doi.org/10.1101/2022.10.22.513328 +S269L,NP_000537:p.Ser269Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.00657,0.4481649398803711,1.16395,-0.2841366415778701,0.58526,-0.13878332078893504,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.2572,1.0942,-22.2302,-4.39683064233223,0.6487539187709113,Uncertain,0.4537,ambiguous,-3.997,available,https://doi.org/10.1101/2022.10.22.513328 +S269M,NP_000537:p.Ser269Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-2.19716,0.0536036491394043,0.18503,-0.1130754432394054,-1.006065,-1.1551177216197026,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,uncertain,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.2283,1.0942,-22.2302,-4.61654398982983,0.7778011431218738,Pathogenic,0.5609,ambiguous,-4.08,available,https://doi.org/10.1101/2022.10.22.513328 +S269N,NP_000537:p.Ser269Asn,"hg19,17:g.7577132C>T, hg38,17:g.7673814C>T",,,0.729,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3076193,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.98013,1.0965722799301147,1.05952,0.2137571299120921,1.019825,0.5969435649560461,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.1291,1.0942,-7.9424,-4.25800922113961,0.4034656080538056,Uncertain,0.4728,ambiguous,-3.77,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269P,NP_000537:p.Ser269Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.45517,1.2347804307937622,2.05306,2.841362077080274,1.2541149999999999,1.6482660385401369,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.2654,1.0942,-8.9424,-4.45084374383499,0.7552530448635252,Pathogenic,0.9168,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328 +S269Q,NP_000537:p.Ser269Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.20763,0.2811644077301025,1.48605,0.4444237531829231,0.84684,0.32602687659146157,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.2217,1.0942,-22.2302,-5.91168618561201,0.850662972355603,Pathogenic,0.887,pathogenic,-4.3,available,https://doi.org/10.1101/2022.10.22.513328 +S269R,NP_000537:p.Ser269Arg,"hg19,17:g.7577131G>C, hg19,17:g.7577133T>G, hg38,17:g.7673813G>C, hg38,17:g.7673813G>T, hg38,17:g.7673815T>G",,,"0.793, 0.812","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","2113149, 647256","Uncertain significance, Uncertain significance","2, 1",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.21369,0.5330855846405029,1.13129,0.3056849676693152,-0.041200000000000014,-0.4540025161653424,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.2736,1.0942,-22.2302,-4.35152183098193,0.17116262508089,Benign,0.9398,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269T,NP_000537:p.Ser269Thr,"hg19,17:g.7577132C>G, hg38,17:g.7673814C>G",,,0.603,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.58972,0.1259433627128601,0.85748,0.1783461055737961,1.2236,0.884033052786898,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,neutral,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.0924,1.0942,-6.9425,-1.69761692650551,0.0190920773132126,Benign,0.1301,benign,-3.5,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +S269V,NP_000537:p.Ser269Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.11819,-0.456138014793396,0.19388,-0.2414876230472956,0.037845,-0.1798388115236478,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.2352,1.0942,-22.2302,-3.56821591465137,0.0648208850928016,Benign,0.3851,ambiguous,-3.57,available,https://doi.org/10.1101/2022.10.22.513328 +S269W,NP_000537:p.Ser269Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.72798,-0.7369606494903564,-0.78231,-0.5563948055954399,-0.027164999999999995,0.08579259720228005,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.2675,1.0942,-22.2302,-5.58557411384376,0.8438632066767293,Pathogenic,0.8497,pathogenic,-4.384,available,https://doi.org/10.1101/2022.10.22.513328 +S269Y,NP_000537:p.Ser269Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.62853,-0.7589786052703857,-0.60816,-0.61923208103142,0.010185,0.004648959484290005,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.039,,,,,,,,,10.7,P,True,10.7,4.182,uncertain,damaging,uncertain,UP,neutral,neutral,False,neutral,neutral,98.0,E,-0.2626,1.0942,-22.2302,-5.06353889053765,0.7717714500532307,Pathogenic,0.6829,pathogenic,-4.041,available,https://doi.org/10.1101/2022.10.22.513328 +F270A,NP_000537:p.Phe270Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.72292,2.3501601219177246,4.55816,3.881600597889112,5.14054,4.802260298944557,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.4454,0.0423,-22.2302,-6.91503110018152,0.8488288460465558,Pathogenic,0.9956,pathogenic,-4.434,available,https://doi.org/10.1101/2022.10.22.513328 +F270C,NP_000537:p.Phe270Cys,"hg19,17:g.7577129A>C, hg19,17:g.7673811A>C, hg38,17:g.7673811A>C",,,0.929,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376597,Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.06435,1.4163966178894043,4.31361,4.286101990518314,4.68898,4.675225995259157,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.4135,0.0423,-22.2302,-5.54328700988529,0.7272656398596062,Pathogenic,0.9612,pathogenic,-4.002,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F270D,NP_000537:p.Phe270Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.1113,1.996328353881836,6.31871,5.251222403334997,6.715005,6.181261201667498,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.5683,0.0423,-22.2302,-6.96496115851168,0.8695558971552554,Pathogenic,0.9998,pathogenic,-4.829,available,https://doi.org/10.1101/2022.10.22.513328 +F270E,NP_000537:p.Phe270Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.08543,2.528326988220215,6.00748,5.056705308663072,6.046455,5.571067654331536,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.5377,0.0423,-22.2302,-6.96496115851168,0.854007999523428,Pathogenic,0.9995,pathogenic,-4.784,available,https://doi.org/10.1101/2022.10.22.513328 +F270G,NP_000537:p.Phe270Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.14273,2.552728176116944,6.55578,5.688891608856765,6.849255,6.415810804428382,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.4807,0.0423,-22.2302,-7.69257588144644,0.8359972659831771,Pathogenic,0.9987,pathogenic,-4.615,available,https://doi.org/10.1101/2022.10.22.513328 +F270H,NP_000537:p.Phe270His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.9718,2.780026912689209,2.82551,2.426367707378033,3.3986549999999998,3.1990838536890163,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.4729,0.0423,-22.2302,-4.63948944499405,0.8691503084231919,Pathogenic,0.9957,pathogenic,-4.57,available,https://doi.org/10.1101/2022.10.22.513328 +F270I,NP_000537:p.Phe270Ile,"hg19,17:g.7577130A>T, hg19,17:g.7673812A>T, hg38,17:g.7673812A>T",,,0.938,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376596,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.69224,1.3079921007156372,2.86497,2.8322865490768514,2.7786049999999998,2.7622632745384257,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.3893,0.0423,-22.2302,-4.46839511542668,0.4034463313779977,Uncertain,0.9152,pathogenic,-3.721,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F270K,NP_000537:p.Phe270Lys,"hg19,17:g.7577128_7577130delinsTTT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.12567,2.50199031829834,6.56633,5.2100186058193305,6.346,5.667844302909666,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.5446,0.0423,-22.2302,-7.69257588144644,0.8667230697865627,Pathogenic,0.9994,pathogenic,-4.744,available,https://doi.org/10.1101/2022.10.22.513328 +F270L,NP_000537:p.Phe270Leu,"hg19,17:g.7577128A>C, hg19,17:g.7577128A>T, hg19,17:g.7577130A>G, hg19,17:g.7673810A>C, hg19,17:g.7673812A>G, hg38,17:g.7673810A>C, hg38,17:g.7673810A>T, hg38,17:g.7673812A>G",,,"0.827, 0.935","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","1431729, 634778","Conflicting classifications of pathogenicity, Conflicting classifications of pathogenicity","1, 1",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.5274,1.53823983669281,2.41871,2.1670877407838285,2.973055,2.8472438703919143,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.2836,0.0423,-8.9424,-3.45216713202377,0.3973499295870359,Uncertain,0.9944,pathogenic,-3.693,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F270M,NP_000537:p.Phe270Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42125,1.499696969985962,3.06973,2.641116637570361,2.2454899999999998,2.0311833187851804,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.3824,0.0423,-22.2302,-4.58205857622468,0.5023578242858687,Uncertain,0.9642,pathogenic,-3.83,available,https://doi.org/10.1101/2022.10.22.513328 +F270N,NP_000537:p.Phe270Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.89033,2.394660234451294,4.82959,3.966076063679006,5.359959999999999,4.9282030318395025,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.498,0.0423,-22.2302,-6.96496115851168,0.8629443161140484,Pathogenic,0.9991,pathogenic,-4.674,available,https://doi.org/10.1101/2022.10.22.513328 +F270P,NP_000537:p.Phe270Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.29537,2.4488797187805176,7.73878,7.875499650616553,7.017075,7.085434825308276,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.5009,0.0423,-8.9424,-7.69257588144644,0.8647623117971187,Pathogenic,0.9999,pathogenic,-4.649,available,https://doi.org/10.1101/2022.10.22.513328 +F270Q,NP_000537:p.Phe270Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.29602,2.606938123703003,4.58469,4.092181130848994,4.940355,4.694100565424497,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.5,0.0423,-22.2302,-6.02793001538936,0.864251922979483,Pathogenic,0.9986,pathogenic,-4.47,available,https://doi.org/10.1101/2022.10.22.513328 +F270R,NP_000537:p.Phe270Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.15856,2.408982753753662,4.56769,4.189120997019864,5.863125,5.673840498509932,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.5459,0.0423,-22.2302,-7.69257588144644,0.864144345054376,Pathogenic,0.9978,pathogenic,-4.666,available,https://doi.org/10.1101/2022.10.22.513328 +F270S,NP_000537:p.Phe270Ser,"hg19,17:g.7577129A>G, hg19,17:g.7673811A>G, hg38,17:g.7673811A>G",,,0.945,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376594,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.60906,2.1072568893432617,5.13707,4.735511287323289,5.373065,5.172285643661645,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.4243,0.0423,-22.2302,-6.91503110018152,0.8687453529404657,Pathogenic,0.9952,pathogenic,-4.405,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F270T,NP_000537:p.Phe270Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.03352,1.949817419052124,4.58027,4.106182036180814,4.806895,4.569851018090407,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.4706,0.0423,-22.2302,-6.91503110018152,0.8524391291747411,Pathogenic,0.9945,pathogenic,-4.354,available,https://doi.org/10.1101/2022.10.22.513328 +F270V,NP_000537:p.Phe270Val,"hg19,17:g.7577130A>C, hg19,17:g.7673812A>C, hg38,17:g.7673812A>C",,,0.926,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376598,Pathogenic,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,3.68489,1.4640337228775024,2.81293,3.0545714111561155,3.2489100000000004,3.369730705578058,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,98.3,E,-0.3836,0.0423,-22.2302,-4.18485049707298,0.5207188382346581,Uncertain,0.882,pathogenic,-3.732,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +F270W,NP_000537:p.Phe270Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.43083,1.9360668659210205,0.41769,0.4288133688244788,1.4242599999999999,1.4298216844122393,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,98.3,E,-0.3689,0.0423,-22.2302,-4.63948944499405,0.8660040601329309,Pathogenic,0.9186,pathogenic,-4.442,available,https://doi.org/10.1101/2022.10.22.513328 +F270Y,NP_000537:p.Phe270Tyr,"hg38,17:g.7673811A>T",,,0.936,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.82755,1.9080541133880613,-0.29354,0.2722432932991414,0.267005,0.5498966466495707,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.058,,,,,,,,,0.2,,True,0.2,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.3,E,-0.3372,0.0423,-22.2302,-4.63948944499405,0.8698200708825938,Pathogenic,0.8656,pathogenic,-4.238,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271A,NP_000537:p.Glu271Ala,"hg19,17:g.7673808T>G",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35709,0.2128841876983642,1.2432,0.7377865020151527,0.8001450000000001,0.5474382510075764,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.38,E,-0.3148,0.0634,-22.2302,-6.17285794794044,0.7184220630176705,Pathogenic,0.8063,pathogenic,-4.092,available,https://doi.org/10.1101/2022.10.22.513328 +E271C,NP_000537:p.Glu271Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.63847,-0.0428779125213623,1.48197,1.2773762412765517,1.06022,0.9579231206382759,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.38,E,-0.3841,0.0634,-22.2302,-6.6845952639708,0.8696747628253019,Pathogenic,0.9833,pathogenic,-4.528,available,https://doi.org/10.1101/2022.10.22.513328 +E271D,NP_000537:p.Glu271Asp,"hg19,17:g.7577125C>A, hg19,17:g.7673807C>G, hg38,17:g.7673807C>A, hg38,17:g.7673807C>G",,,"0.843, 0.844","cBioPortal,COSMIC,ClinVar,saturation_mutlist",859912,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.16943,0.2916597127914428,0.72007,0.933861865872136,0.94475,1.0516459329360681,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.38,E,-0.2127,0.0634,-8.9424,-2.75745417207769,0.0068975054763492,Benign,0.7768,pathogenic,-3.578,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271F,NP_000537:p.Glu271Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.474,0.4443659782409668,1.82449,-0.1575142289722947,2.149245,1.1582428855138527,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.38,E,-0.3618,0.0634,-22.2302,-7.14051568551294,0.8683630282278967,Pathogenic,0.9936,pathogenic,-4.672,available,https://doi.org/10.1101/2022.10.22.513328 +E271G,NP_000537:p.Glu271Gly,"hg19,17:g.7577126T>C, hg38,17:g.7673808T>C",,,0.967,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2858983,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.49849,0.2109451293945312,2.62755,1.93297230472292,2.06302,1.71573115236146,Uncertain,Neutral,Neutral,Uncertain,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.38,E,-0.3405,0.0634,-22.2302,-5.1338776088959,0.6242456099800583,Uncertain,0.8534,pathogenic,-4.093,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271H,NP_000537:p.Glu271His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.59143,0.6292816996574402,1.44728,0.3211040524664682,2.519355,1.956267026233234,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.38,E,-0.353,0.0634,-22.2302,-6.76498148786276,0.7414448442698767,Pathogenic,0.9738,pathogenic,-4.246,available,https://doi.org/10.1101/2022.10.22.513328 +E271I,NP_000537:p.Glu271Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.04384,0.940136730670929,0.23776,-0.2919510052563934,-0.40304000000000006,-0.6678955026281967,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.38,E,-0.3671,0.0634,-22.2302,-7.08214190607596,0.8667602284663278,Pathogenic,0.9811,pathogenic,-4.656,available,https://doi.org/10.1101/2022.10.22.513328 +E271K,NP_000537:p.Glu271Lys,"hg19,17:g.7577127C>T, hg19,17:g.7673809C>T, hg38,17:g.7673809C>T",,,0.935,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",406566,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30134,1.1672990322113037,2.08163,0.941210095902946,1.1914850000000001,0.621275047951473,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.38,E,-0.269,0.0634,-8.9424,-5.99359737796003,0.638852324463939,Uncertain,0.9532,pathogenic,-4.157,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271L,NP_000537:p.Glu271Leu,"hg19,17:g.7577126_7577127delinsAA, hg38,17:g.7673808_7673809delinsAA",,,,"ClinVar,saturation_mutlist",568838,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.13368,0.7164053916931152,0.96327,-0.2359127095811447,0.5484749999999999,-0.051116354790572346,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.38,E,-0.3692,0.0634,-22.2302,-6.79199726822656,0.694915266544585,Pathogenic,0.9679,pathogenic,-4.238,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271M,NP_000537:p.Glu271Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.15493,0.561934232711792,1.32993,0.1957252155680428,0.74243,0.1753276077840214,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.38,E,-0.3181,0.0634,-22.2302,-7.08214190607596,0.868121252134773,Pathogenic,0.968,pathogenic,-4.636,available,https://doi.org/10.1101/2022.10.22.513328 +E271N,NP_000537:p.Glu271Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.64223,0.8479446172714233,1.33844,0.7829628719176451,1.490335,1.2125964359588226,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.38,E,-0.341,0.0634,-22.2302,-3.74959058021178,0.522641305801466,Uncertain,0.9324,pathogenic,-4.102,available,https://doi.org/10.1101/2022.10.22.513328 +E271P,NP_000537:p.Glu271Pro,"hg38,17:g.7673808_7673809delinsGG",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.4056,1.769853591918945,3.32245,3.043883258309433,1.864025,1.7247416291547166,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.38,E,-0.4039,0.0634,-8.9424,-6.13874495590501,0.5515815464806931,Uncertain,0.9819,pathogenic,-4.238,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271Q,NP_000537:p.Glu271Gln,"hg19,17:g.7577127C>G, hg19,17:g.7673809C>G, hg38,17:g.7673809C>G",,,0.924,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3634426,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.50551,0.5718594193458557,1.17857,0.636470623516529,0.8420399999999999,0.5709903117582645,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.38,E,-0.2873,0.0634,-22.2302,-4.5582696722585,0.728915006186129,Pathogenic,0.7442,pathogenic,-4.064,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271R,NP_000537:p.Glu271Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.01873,1.197190761566162,1.58095,0.6350333124862645,1.29984,0.8268816562431323,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.38,E,-0.3973,0.0634,-22.2302,-6.34892669683129,0.8708540421658563,Pathogenic,0.959,pathogenic,-4.384,available,https://doi.org/10.1101/2022.10.22.513328 +E271S,NP_000537:p.Glu271Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.67997,0.5376895070075989,1.39456,1.4204048499291224,1.037265,1.050187424964561,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.38,E,-0.3282,0.0634,-22.2302,-5.58745827247622,0.6642086452207352,Uncertain,0.8257,pathogenic,-4.129,available,https://doi.org/10.1101/2022.10.22.513328 +E271T,NP_000537:p.Glu271Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.22289,0.750110387802124,0.46224,0.8640935543555669,0.11967499999999999,0.32060177717778343,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,98.38,E,-0.3441,0.0634,-22.2302,-6.6845952639708,0.8530171405816365,Pathogenic,0.9497,pathogenic,-4.454,available,https://doi.org/10.1101/2022.10.22.513328 +E271V,NP_000537:p.Glu271Val,"hg19,17:g.7577126T>A, hg19,17:g.7673808T>A, hg38,17:g.7673808T>A",,,0.972,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3147994,Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.7037,1.0074238777160645,0.30306,-0.0788785263720082,-0.20032,-0.3912892631860041,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.38,E,-0.328,0.0634,-22.2302,-7.08214190607596,0.859649952722136,Pathogenic,0.9457,pathogenic,-4.434,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E271W,NP_000537:p.Glu271Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.98459,0.0454323291778564,1.74422,-0.3603764471735543,3.364405,2.3121067764132226,Uncertain,Uncertain,Neutral,Destabilizing,Uncertain,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.38,E,-0.3718,0.0634,-22.2302,-7.14051568551294,0.8708183379723466,Pathogenic,0.9971,pathogenic,-4.797,available,https://doi.org/10.1101/2022.10.22.513328 +E271Y,NP_000537:p.Glu271Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.62462,0.2380790114402771,1.17823,0.0414837613506346,0.901425,0.33305188067531727,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.092,,,,,,,,,10.3,,True,10.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.38,E,-0.3626,0.0634,-22.2302,-6.87743560539688,0.8575961504579961,Pathogenic,0.9894,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328 +V272A,NP_000537:p.Val272Ala,"hg19,17:g.7577123A>G, hg19,17:g.7673805A>G, hg38,17:g.7673805A>G",,,0.658,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",565884,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.60238,2.2906057834625244,2.57857,2.981723048342449,3.090475,3.2920515241712245,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.233,0.00652,0.14101,Neutral,0.00667,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.62,E,-0.1077,1.4791,-1.2283,-2.15184917570093,0.0017245284391972,Benign,0.9028,pathogenic,-3.32,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V272C,NP_000537:p.Val272Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.95727,1.4301621913909912,1.94592,2.8156517337198275,2.451595,2.8864608668599137,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.233,0.00274,,,0.01129,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,damaging,98.62,E,-0.2427,1.4791,-22.2302,-4.0008210332106,0.8688226318888297,Pathogenic,0.9792,pathogenic,-4.193,available,https://doi.org/10.1101/2022.10.22.513328 +V272D,NP_000537:p.Val272Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.51831,3.699053287506104,4.97109,4.506636705664053,4.7447,4.512473352832027,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,0.19794,,,-0.04152,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.62,E,-0.3814,1.4791,-22.2302,-6.48435979193118,0.8690175053985187,Pathogenic,0.9969,pathogenic,-4.629,available,https://doi.org/10.1101/2022.10.22.513328 +V272E,NP_000537:p.Val272Glu,"hg19,17:g.7577123A>T, hg19,17:g.7673805A>T, hg38,17:g.7673805A>T",,,0.806,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376673,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.49332,3.562283515930176,4.65238,4.590330639491481,6.07285,6.04182531974574,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,0.19648,0.00779,Neutral,-0.04041,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.62,E,-0.3387,1.4791,-22.2302,-6.48435979193118,0.8707036106879041,Pathogenic,0.9937,pathogenic,-4.549,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V272F,NP_000537:p.Val272Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.13356,2.451871871948242,3.08333,3.377948845834988,5.108445,5.255754422917494,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,-0.01248,,,0.0072,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.62,E,-0.292,1.4791,-22.2302,-6.48435979193118,0.8478046969785913,Pathogenic,0.9706,pathogenic,-4.108,available,https://doi.org/10.1101/2022.10.22.513328 +V272G,NP_000537:p.Val272Gly,"hg19,17:g.7577123A>C, hg19,17:g.7673805A>C, hg38,17:g.7673805A>C",,,0.707,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",233323,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.6112,3.271545648574829,5.06837,5.031032906061353,5.339785,5.321116453030676,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,0.01354,-0.12513,Neutral,0.01353,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.62,E,-0.2411,1.4791,-2.7331,-2.44295666055379,0.5781006223116738,Uncertain,0.8186,pathogenic,-3.722,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V272H,NP_000537:p.Val272His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.47915,3.404527425765991,4.31837,3.9344347469682073,5.398759999999999,5.206792373484103,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,-0.00372,,,0.00908,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.62,E,-0.3844,1.4791,-22.2302,-6.48435979193118,0.8608250919014535,Pathogenic,0.9991,pathogenic,-4.637,available,https://doi.org/10.1101/2022.10.22.513328 +V272I,NP_000537:p.Val272Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.37653,0.4853096008300781,1.09422,1.0608354024468338,1.735375,1.718682701223417,Uncertain,Uncertain,Neutral,Neutral,Neutral,True,0.233,-0.00096,,,-0.00141,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.62,E,-0.1504,1.4791,-22.2302,-3.22135203996412,0.1719615117827245,Benign,0.3344,benign,-3.504,available,https://doi.org/10.1101/2022.10.22.513328 +V272K,NP_000537:p.Val272Lys,"hg19,17:g.7577123_7577124delinsTT, hg38,17:g.7673805_7673806delinsTT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.1698,3.4379186630249023,6.03571,6.720418516397575,8.102755,8.445109258198787,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,-0.1167,0.11256,Neutral,0.01378,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.62,E,-0.3777,1.4791,-22.2302,-6.48435979193118,0.8650754758083341,Pathogenic,0.9971,pathogenic,-4.652,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V272L,NP_000537:p.Val272Leu,"hg19,17:g.7577124C>A, hg19,17:g.7577124C>G, hg19,17:g.7673806C>A, hg19,17:g.7673806C>G, hg38,17:g.7673806C>A, hg38,17:g.7673806C>G",,,0.878,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","574679, 12358","Pathogenic, Pathogenic/Likely pathogenic","2, 2",Oncogenic,1,Tier II - Potential,1,P53 DNA-binding domain (PF00870),2.60.40.720,3.30013,1.4968254566192627,1.17483,1.7992591476900743,2.2374799999999997,2.549694573845037,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.233,-0.01314,-0.01976,Neutral,-0.00574,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.62,E,-0.2155,1.4791,-22.2302,-3.54364476514723,0.2306612163995733,Benign,0.9653,pathogenic,-3.728,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V272M,NP_000537:p.Val272Met,"hg19,17:g.7577124C>T, hg19,17:g.7577124_7577125delinsTT, hg19,17:g.7673806C>T, hg38,17:g.7673806C>T",,3.9857787415e-06,0.907,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",185814,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,2.52961,1.95557188987732,1.56327,2.6381706275706422,2.04644,2.583890313785321,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.233,-0.00458,-0.08447,Neutral,-0.01098,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.62,E,-0.2245,1.4791,-22.2302,-4.14864059378533,0.7501014659611975,Pathogenic,0.9572,pathogenic,-4.149,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V272N,NP_000537:p.Val272Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.74145,3.49573278427124,2.87585,3.099853436858524,3.30865,3.420651718429262,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,-0.0056,,,-0.00225,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.62,E,-0.3693,1.4791,-22.2302,-6.48435979193118,0.869897475692885,Pathogenic,0.989,pathogenic,-4.536,available,https://doi.org/10.1101/2022.10.22.513328 +V272P,NP_000537:p.Val272Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,6.28435,3.3550124168396,5.67449,7.153362263160737,5.979419999999999,6.7188561315803685,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,0.0139,,,0.01463,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.62,E,-0.3514,1.4791,-8.9424,-5.53858570879084,0.8550691795977238,Pathogenic,0.9955,pathogenic,-4.424,available,https://doi.org/10.1101/2022.10.22.513328 +V272Q,NP_000537:p.Val272Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.81565,3.3000030517578125,2.88095,3.4508257090312804,4.3483,4.63323785451564,Uncertain,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,0.0028,,,-0.0095,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.62,E,-0.3494,1.4791,-22.2302,-6.48435979193118,0.8513025835516409,Pathogenic,0.9951,pathogenic,-4.6,available,https://doi.org/10.1101/2022.10.22.513328 +V272R,NP_000537:p.Val272Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,11.99863,3.384307861328125,4.65748,5.9699375244561965,8.328054999999999,8.984283762228099,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,-0.28772,,,0.05179,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.62,E,-0.3987,1.4791,-22.2302,-6.48435979193118,0.8544026511294832,Pathogenic,0.9939,pathogenic,-4.654,available,https://doi.org/10.1101/2022.10.22.513328 +V272S,NP_000537:p.Val272Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.1586,2.901425361633301,3.63741,3.754535615816459,3.898005,3.9565678079082294,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,0.0111,,,0.01128,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.62,E,-0.3185,1.4791,-22.2302,-3.27956985911653,0.8706145190734547,Pathogenic,0.9577,pathogenic,-4.22,available,https://doi.org/10.1101/2022.10.22.513328 +V272T,NP_000537:p.Val272Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.90608,1.900928616523743,2.05646,2.5172146763119327,1.9812699999999999,2.2116473381559665,Uncertain,Uncertain,Uncertain,Neutral,Uncertain,True,0.233,0.00164,,,0.00244,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.62,E,-0.2339,1.4791,-22.2302,-3.03160401968157,0.5298429161628423,Uncertain,0.9045,pathogenic,-3.678,available,https://doi.org/10.1101/2022.10.22.513328 +V272W,NP_000537:p.Val272Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,15.09572,2.860581398010254,6.75612,5.386413978867202,10.92592,10.241066989433602,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,0.02144,,,0.00618,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.62,E,-0.3325,1.4791,-22.2302,-6.48435979193118,0.870378770601084,Pathogenic,0.9995,pathogenic,-4.624,available,https://doi.org/10.1101/2022.10.22.513328 +V272Y,NP_000537:p.Val272Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.554,2.8979527950286865,6.29626,4.561794474626716,7.92513,7.057897237313358,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.233,-0.01142,,,0.00825,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.62,E,-0.3354,1.4791,-22.2302,-6.48435979193118,0.87068422867261,Pathogenic,0.9967,pathogenic,-4.614,available,https://doi.org/10.1101/2022.10.22.513328 +R273A,NP_000537:p.Arg273Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.1533,1.031935453414917,1.31088,0.9391547072211972,1.23209,1.0462273536105986,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.296,2.94402,,Uncertain,0.40201,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.4036,0.0682,-22.2302,-7.11021169620391,0.8492271311929989,Pathogenic,0.9989,pathogenic,-4.611,available,https://doi.org/10.1101/2022.10.22.513328 +R273C,NP_000537:p.Arg273Cys,"hg19,17:g.7577121G>A, hg19,17:g.7577121_7577122delinsAA, hg19,17:g.7673803G>A, hg38,17:g.7673803G>A, hg38,17:g.7673803_7673804delinsAG",0.0,1.195933825e-05,0.901,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",43594,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.14497,0.4396446943283081,1.27959,1.6411316537914125,1.21228,1.3930508268957063,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,3.6383,0.28124,Uncertain,0.34865,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.4124,0.0682,-22.2302,-4.01724918554044,0.5826370316456644,Uncertain,0.9945,pathogenic,-4.172,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273D,NP_000537:p.Arg273Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.03542,1.1195870637893677,1.72517,1.7918340146882985,1.380295,1.4136270073441493,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.296,3.95026,,Uncertain,0.52648,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.4946,0.0682,-22.2302,-7.62147705658493,0.8480958097282811,Pathogenic,0.9994,pathogenic,-4.82,available,https://doi.org/10.1101/2022.10.22.513328 +R273E,NP_000537:p.Arg273Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.86641,0.9104464054107666,0.45986,1.446715915691791,0.663135,1.1565629578458956,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,2.81086,,Uncertain,0.6581,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.4398,0.0682,-22.2302,-7.62147705658493,0.8465504936627113,Pathogenic,0.9978,pathogenic,-4.742,available,https://doi.org/10.1101/2022.10.22.513328 +R273F,NP_000537:p.Arg273Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.00804,0.4751999974250793,-0.11156,0.0124115683256603,-0.5598000000000001,-0.4978142158371699,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,2.75786,,Uncertain,0.79645,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.43,E,-0.4357,0.0682,-22.2302,-6.57658797529699,0.7772526639907797,Pathogenic,0.9994,pathogenic,-4.706,available,https://doi.org/10.1101/2022.10.22.513328 +R273G,NP_000537:p.Arg273Gly,"hg19,17:g.7577121G>C, hg19,17:g.7577121_7577122delinsCT, hg19,17:g.7673803G>C, hg38,17:g.7673803G>C",,,0.902,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",634682,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.57054,2.211817741394043,3.27041,2.227976822221017,2.9204749999999997,2.3992584111105084,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.296,4.44394,0.55543,Uncertain,0.41666,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.4389,0.0682,-22.2302,-7.62147705658493,0.7976161942894914,Pathogenic,0.9981,pathogenic,-4.506,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273H,NP_000537:p.Arg273His,"hg19,17:g.7577120C>T, hg19,17:g.7673802C>T, hg38,17:g.7673802C>T",,1.59328272005e-05,0.868,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12366,Pathogenic,3,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,-0.27834,0.5412669777870178,0.57483,0.6843339858807279,0.148245,0.20299699294036397,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,2.19578,0.16337,Uncertain,1.12626,Destabilizing,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.2953,0.0682,-6.9425,-2.02805387219135,0.0005848995091557,Benign,0.9889,pathogenic,-3.658,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273I,NP_000537:p.Arg273Ile,"hg38,17:g.7673802_7673803delinsAT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.4739,0.4267343282699585,0.85748,0.1600633752489644,0.66569,0.3169816876244822,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,3.09914,,Uncertain,0.4634,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.433,0.0682,-22.2302,-7.62147705658493,0.8245679301443909,Pathogenic,0.9983,pathogenic,-4.62,available,https://doi.org/10.1101/2022.10.22.513328 +R273K,NP_000537:p.Arg273Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.07981,0.5153165459632874,0.76531,0.9430529523458198,0.34275,0.43162147617290986,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,2.47518,,Uncertain,0.38527,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,98.43,E,-0.2938,0.0682,-22.2302,-3.71893592246007,0.0028011958615303,Benign,0.9578,pathogenic,-3.524,available,https://doi.org/10.1101/2022.10.22.513328 +R273L,NP_000537:p.Arg273Leu,"hg19,17:g.7577120C>A, hg19,17:g.7673802C>A, hg38,17:g.7673802C>A",,3.9832068001e-06,0.921,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376655,Pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,-0.73658,0.3753111362457275,-0.51054,-0.2676033440286929,-0.62356,-0.5020916720143465,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,2.89996,0.42294,Uncertain,0.57512,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.406,0.0682,-22.2302,-7.62147705658493,0.847018623778218,Pathogenic,0.9954,pathogenic,-4.49,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273M,NP_000537:p.Arg273Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.34026,0.639156699180603,0.23571,0.2743671329315167,-0.052275,-0.03294643353424165,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,2.44482,,Uncertain,0.6414,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.3719,0.0682,-22.2302,-7.62147705658493,0.8395117372104879,Pathogenic,0.9995,pathogenic,-4.581,available,https://doi.org/10.1101/2022.10.22.513328 +R273N,NP_000537:p.Arg273Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.12293,0.7972500324249268,1.25952,1.1571151991906927,0.691225,0.6400225995953464,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,3.89368,0.47054,Uncertain,0.52119,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.4184,0.0682,-22.2302,-7.62147705658493,0.852486193748081,Pathogenic,0.9995,pathogenic,-4.508,available,https://doi.org/10.1101/2022.10.22.513328 +R273P,NP_000537:p.Arg273Pro,"hg19,17:g.7577120C>G, hg19,17:g.7673802C>G, hg38,17:g.7673802C>G",3.1867431485e-05,,0.932,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",231060,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.6269,2.5556411743164062,3.5602,6.204393242763786,4.5935500000000005,5.915646621381892,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.296,3.70314,1.93511,Destabilizing,0.50395,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.5456,0.0682,-22.2302,-7.62147705658493,0.8579175131324634,Pathogenic,0.9988,pathogenic,-4.644,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273Q,NP_000537:p.Arg273Gln,"hg38,17:g.7673801_7673802delinsCT",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.11018,0.8745880126953125,0.44388,1.0025424167481114,0.27703,0.5563612083740557,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,3.00112,0.64778,Uncertain,0.50284,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.3783,0.0682,-22.2302,-7.62147705658493,0.8220576603716665,Pathogenic,0.9917,pathogenic,-4.02,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273S,NP_000537:p.Arg273Ser,"hg19,17:g.7577121G>T, hg19,17:g.7577121_7577122delinsTT, hg19,17:g.7673803G>T, hg38,17:g.7673801_7673803delinsCGA, hg38,17:g.7673803G>T, hg38,17:g.7673803_7673804delinsTT",,0.0,0.906,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","4530236, 376656",Pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.66603,0.971648931503296,1.45408,1.722458456241699,1.560055,1.6942442281208494,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,3.38162,0.5557,Uncertain,0.42749,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.4041,0.0682,-22.2302,-7.11021169620391,0.7944171265922608,Pathogenic,0.9993,pathogenic,-4.424,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273T,NP_000537:p.Arg273Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.69235,0.8516272306442261,0.7602,1.2821301885498249,1.226275,1.4872400942749124,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,3.18706,,Uncertain,0.43388,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.4084,0.0682,-22.2302,-7.11021169620391,0.8405807145933339,Pathogenic,0.9991,pathogenic,-4.472,available,https://doi.org/10.1101/2022.10.22.513328 +R273V,NP_000537:p.Arg273Val,"hg19,17:g.7577120_7577121delinsAC",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.17963,0.3905009031295776,0.06497,0.3251659474833313,0.6223,0.7523979737416656,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,3.50692,0.45698,Uncertain,0.39156,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,98.43,E,-0.4201,0.0682,-22.2302,-7.62147705658493,0.8327354327096622,Pathogenic,0.9978,pathogenic,-4.608,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R273W,NP_000537:p.Arg273Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.85213,0.4670785069465637,-0.71156,-0.3342769480614432,-0.781845,-0.5932034740307216,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,2.7841,,Uncertain,1.24358,Destabilizing,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.43,E,-0.4213,0.0682,-22.2302,-6.57658797529699,0.8502494239592289,Pathogenic,0.9908,pathogenic,-4.482,available,https://doi.org/10.1101/2022.10.22.513328 +R273Y,NP_000537:p.Arg273Tyr,"hg19,17:g.7577120_7577121delinsTA, hg38,17:g.7673802_7673803delinsTA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.38273,0.3921879529953003,-0.22279,0.2668453528324566,-0.80276,-0.5579423235837717,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.296,2.53036,0.53377,Uncertain,0.12178,Neutral,,,Uncertain,41.8,,False,41.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,98.43,E,-0.425,0.0682,-22.2302,-6.57658797529699,0.8488924651125445,Pathogenic,0.9985,pathogenic,-4.625,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274A,NP_000537:p.Val274Ala,"hg19,17:g.7577117A>G, hg19,17:g.7673799A>G, hg38,17:g.7673799A>G",,,0.847,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376677,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.54178,2.38458251953125,2.84966,2.910652665370766,2.69572,2.726216332685383,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.27,0.02548,0.0964,Neutral,0.041,Neutral,0.05223,-0.01959,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,98.6,E,-0.2627,0.9589,-22.2302,-6.80217081269693,0.513378503089405,Uncertain,0.9908,pathogenic,-3.946,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274C,NP_000537:p.Val274Cys,"hg19,17:g.7577117_7577118delinsCA, hg19,17:g.7673799_7673800delinsCA",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.28041,1.5167869329452517,2.0898,2.550218945222703,2.185105,2.4153144726113513,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.27,-0.00674,-0.0362,Neutral,0.02642,Neutral,0.06643,-0.00245,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,98.6,E,-0.2906,0.9589,-22.2302,-6.80217081269693,0.6183762516416454,Uncertain,0.9942,pathogenic,-4.005,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274D,NP_000537:p.Val274Asp,"hg19,17:g.7577117A>T, hg19,17:g.7673799A>T, hg38,17:g.7673799A>T",,,0.889,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376675,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.04508,3.036308765411377,5.00612,4.078991068534621,4.5256,4.06203553426731,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.27,0.46334,0.02604,Neutral,-0.05758,Neutral,0.09695,0.10681,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,98.6,E,-0.4293,0.9589,-22.2302,-6.80217081269693,0.8390067209925576,Pathogenic,0.9991,pathogenic,-4.632,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274E,NP_000537:p.Val274Glu,"hg19,17:g.7577116_7577117inv, hg38,17:g.7673798_7673799inv",,,,"ClinVar,saturation_mutlist",1417760,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.47664,3.0986437797546387,6.13844,4.0990318885275085,4.80754,3.7878359442637546,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.27,0.48912,0.14312,Neutral,-0.09072,Neutral,0.08769,-0.0219,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,98.6,E,-0.3866,0.9589,-22.2302,-6.80217081269693,0.8377260209128816,Pathogenic,0.9984,pathogenic,-4.591,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274F,NP_000537:p.Val274Phe,"hg19,17:g.7577118C>A, hg19,17:g.7577118_7577119delinsAC, hg19,17:g.7673800C>A, hg38,17:g.7673800C>A",,,0.773,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376674,Conflicting classifications of pathogenicity,1,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,14.20895,2.205930233001709,3.8017,2.761129251137972,9.005325,8.485039625568985,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,True,0.27,0.06908,0.02847,Neutral,0.00321,Neutral,0.05957,0.14536,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,98.6,E,-0.272,0.9589,-8.9424,-6.80217081269693,0.7351823760284366,Pathogenic,0.9915,pathogenic,-4.236,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274G,NP_000537:p.Val274Gly,"hg19,17:g.7577117A>C, hg19,17:g.7673799A>C, hg38,17:g.7673799A>C",,,0.865,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376676,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.16979,3.031795024871826,5.25748,4.958410986756869,4.713635,4.564100493378435,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.27,0.01526,-0.01072,Neutral,0.03392,Neutral,0.06995,-0.06471,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,98.6,E,-0.3885,0.9589,-22.2302,-6.80217081269693,0.7969953163802151,Pathogenic,0.989,pathogenic,-4.405,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274H,NP_000537:p.Val274His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.09895,3.2174315452575684,4.67585,3.4838667596729835,7.3873999999999995,6.791408379836492,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.27,-0.00742,,,0.00176,Neutral,0.05442,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,98.6,E,-0.4323,0.9589,-22.2302,-6.80217081269693,0.7879744646698204,Pathogenic,0.9997,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +V274I,NP_000537:p.Val274Ile,"hg19,17:g.7577118C>T, hg38,17:g.7673800C>T",,,0.367,"COSMIC,ClinVar,saturation_mutlist",3460325,Benign,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.83746,0.2671494483947754,-0.32211,0.1378459721283531,-0.579785,-0.3498070139358235,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.27,0.04324,0.1588,Neutral,0.02666,Neutral,0.0063,0.11857,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,98.6,E,-0.0881,0.9589,-0.6387,-0.311767547129325,1.1555261292893519e-10,Benign,0.0913,benign,-2.786,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274K,NP_000537:p.Val274Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.20846,3.145357608795166,5.9568,5.83802415967591,6.58263,6.523242079837955,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.27,-0.23508,,,0.04246,Neutral,0.04459,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,98.6,E,-0.4256,0.9589,-22.2302,-6.80217081269693,0.7959396260329111,Pathogenic,0.9991,pathogenic,-4.616,available,https://doi.org/10.1101/2022.10.22.513328 +V274L,NP_000537:p.Val274Leu,"hg19,17:g.7577118C>G, hg19,17:g.7673800C>G, hg38,17:g.7673800C>G",,,0.630,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376678,Conflicting classifications of pathogenicity,1,Uncertain significance,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.4734,1.1415678262710571,1.44456,0.762947589789516,2.45898,2.118173794894758,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,True,0.27,-0.03408,0.19756,Neutral,-0.00528,Neutral,0.02876,-0.21123,Neutral,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,98.6,E,-0.2633,0.9589,-22.2302,-3.55708445755812,0.0156181227142313,Benign,0.967,pathogenic,-3.75,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +V274M,NP_000537:p.Val274Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.63818,1.7970712184906006,1.62517,1.9754873166375608,1.631675,1.8068336583187805,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.27,-0.02212,,,0.00256,Neutral,0.0672,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,98.6,E,-0.2724,0.9589,-22.2302,-4.08312790585859,0.5215561213147862,Uncertain,0.984,pathogenic,-3.964,available,https://doi.org/10.1101/2022.10.22.513328 +V274N,NP_000537:p.Val274Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.58547,3.1344640254974365,2.79932,2.610526635842674,2.192395,2.097998317921337,Uncertain,Uncertain,Destabilizing,Uncertain,Uncertain,True,0.27,-0.0248,,,-0.00085,Neutral,0.07394,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,98.6,E,-0.4171,0.9589,-22.2302,-6.80217081269693,0.6871747564077793,Pathogenic,0.9964,pathogenic,-4.46,available,https://doi.org/10.1101/2022.10.22.513328 +V274P,NP_000537:p.Val274Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.42437,2.4100358486175537,2.74762,5.440674217878114,2.085995,3.432522108939057,Uncertain,Uncertain,Destabilizing,Uncertain,Destabilizing,True,0.27,-0.01082,,,0.07125,Neutral,0.0361,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,98.6,E,-0.467,0.9589,-22.2302,-5.66142453448823,0.6091732029934918,Uncertain,0.9903,pathogenic,-4.32,available,https://doi.org/10.1101/2022.10.22.513328 +V274Q,NP_000537:p.Val274Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.28763,3.0995259284973145,4.44796,3.209455139957811,3.867795,3.2485425699789054,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.27,0.00372,,,-0.01082,Neutral,0.05647,,,0.0,,False,0.0,,neutral,neutral,neutral,-,uncertain,damaging,False,neutral,neutral,98.6,E,-0.3972,0.9589,-22.2302,-6.80217081269693,0.769179437028199,Pathogenic,0.9988,pathogenic,-4.551,available,https://doi.org/10.1101/2022.10.22.513328 +V274R,NP_000537:p.Val274Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,13.66102,3.1195430755615234,9.35884,4.929696341693648,11.50993,9.295358170846825,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.27,-0.60704,,,0.09834,Neutral,0.00449,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,98.6,E,-0.4466,0.9589,-22.2302,-6.80217081269693,0.7921654287148987,Pathogenic,0.9974,pathogenic,-4.582,available,https://doi.org/10.1101/2022.10.22.513328 +V274S,NP_000537:p.Val274Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.31138,2.84865403175354,3.77075,3.7308041968829913,3.541065,3.5210920984414957,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.27,0.0252,,,0.03666,Neutral,0.03363,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,98.6,E,-0.3664,0.9589,-22.2302,-6.80217081269693,0.6436579967094653,Uncertain,0.989,pathogenic,-4.114,available,https://doi.org/10.1101/2022.10.22.513328 +V274T,NP_000537:p.Val274Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.65531,2.0961685180664062,1.93946,2.2252918888742483,1.797385,1.9403009444371242,Neutral,Uncertain,Destabilizing,Neutral,Neutral,True,0.27,0.0056,,,0.02061,Neutral,0.01769,,,0.0,,False,0.0,,neutral,neutral,neutral,DOWN,neutral,damaging,False,neutral,neutral,98.6,E,-0.2817,0.9589,-22.2302,-6.80217081269693,0.7814696396743525,Pathogenic,0.9849,pathogenic,-4.106,available,https://doi.org/10.1101/2022.10.22.513328 +V274W,NP_000537:p.Val274Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,22.78834,2.5407564640045166,9.20646,4.833846760846545,15.9974,13.811093380423273,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.27,0.06608,,,0.06142,Neutral,0.05055,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,98.6,E,-0.3804,0.9589,-22.2302,-6.80217081269693,0.802960280744946,Pathogenic,0.9997,pathogenic,-4.622,available,https://doi.org/10.1101/2022.10.22.513328 +V274Y,NP_000537:p.Val274Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,19.21376,2.725938558578491,9.05238,4.263058004541012,14.13307,11.738409002270506,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,True,0.27,0.00606,,,-0.00477,Neutral,0.07238,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,damaging,False,neutral,neutral,98.6,E,-0.3833,0.9589,-22.2302,-6.80217081269693,0.8242594736669258,Pathogenic,0.9989,pathogenic,-4.56,available,https://doi.org/10.1101/2022.10.22.513328 +C275A,NP_000537:p.Cys275Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.34419,0.247109055519104,0.95714,0.8603921580366941,0.650665,0.6022910790183471,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.228,-0.22224,,,-0.04631,Neutral,-0.00282,,,12.4,,False,12.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,-,-0.4905,0.0212,-22.2302,-4.78341883513615,0.8623716638737828,Pathogenic,0.9934,pathogenic,-4.806,available,https://doi.org/10.1101/2022.10.22.513328 +C275D,NP_000537:p.Cys275Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.11518,1.1494401693344116,1.14082,0.7906908263219103,2.128,1.9529354131609553,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.228,0.95458,,,-0.23866,Neutral,0.14166,,,12.4,,False,12.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.98,-,-0.5978,0.0212,-22.2302,-7.96890002094704,0.8637624987638247,Pathogenic,0.9997,pathogenic,-4.96,available,https://doi.org/10.1101/2022.10.22.513328 +C275E,NP_000537:p.Cys275Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35307,1.507737398147583,1.78231,1.0632264780105405,1.06769,0.7081482390052702,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.228,1.03196,,,-0.16096,Neutral,0.11857,,,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.5854,0.0212,-22.2302,-7.96890002094704,0.8361657451072021,Pathogenic,1.0,pathogenic,-4.998,available,https://doi.org/10.1101/2022.10.22.513328 +C275F,NP_000537:p.Cys275Phe,"hg19,17:g.7577114C>A, hg19,17:g.7673796C>A, hg38,17:g.7673795_7673796delinsGA, hg38,17:g.7673796C>A",,,0.981,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376582,Pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.62895,0.8450104594230652,3.60204,0.3938967112607799,2.115495,0.51142335563039,Uncertain,Neutral,Neutral,Uncertain,Neutral,True,0.228,0.86942,0.58724,Neutral,0.7119,Neutral,0.14098,0.00917,Neutral,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.4845,0.0212,-22.2302,-7.96890002094704,0.843023185700425,Pathogenic,0.9978,pathogenic,-4.751,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C275G,NP_000537:p.Cys275Gly,"hg19,17:g.7577115A>C, hg19,17:g.7673797A>C, hg38,17:g.7673797A>C",,,0.957,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1414106,Conflicting classifications of pathogenicity,1,Uncertain significance,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.36569,0.786925196647644,1.87381,1.7857803212019998,1.61975,1.575735160601,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.228,-0.02854,-0.25143,Neutral,0.22522,Neutral,-0.00642,-0.07663,Neutral,12.4,,False,12.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,-,-0.483,0.0212,-22.2302,-7.96890002094704,0.8605076824267808,Pathogenic,0.9926,pathogenic,-4.641,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C275H,NP_000537:p.Cys275His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.89871,1.1883255243301392,2.03129,0.6495734306858449,1.4649999999999999,0.7741417153429224,Uncertain,Neutral,Uncertain,Neutral,Neutral,True,0.228,-0.2354,,,0.34664,Neutral,-0.13938,,,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.5962,0.0212,-22.2302,-7.96890002094704,0.8500059631023835,Pathogenic,0.9996,pathogenic,-4.787,available,https://doi.org/10.1101/2022.10.22.513328 +C275I,NP_000537:p.Cys275Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.18552,0.7235048413276672,1.05,0.2564343263889351,0.61776,0.22097716319446753,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.228,1.41444,,,0.86692,Neutral,-0.0215,,,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.5144,0.0212,-22.2302,-7.96890002094704,0.841537629757133,Pathogenic,0.9992,pathogenic,-4.906,available,https://doi.org/10.1101/2022.10.22.513328 +C275K,NP_000537:p.Cys275Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.66513,1.6383970975875854,3.67789,2.005246922056648,2.67151,1.835188461028324,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.228,0.86126,,,2.10735,Destabilizing,0.01553,,,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.586,0.0212,-22.2302,-7.96890002094704,0.8461548583981611,Pathogenic,1.0,pathogenic,-4.922,available,https://doi.org/10.1101/2022.10.22.513328 +C275L,NP_000537:p.Cys275Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.49417,0.9859389662742616,2.6085,0.4073420317627824,1.551335,0.4507560158813912,Uncertain,Neutral,Neutral,Neutral,Neutral,True,0.228,0.79562,,,0.16933,Neutral,-0.00596,,,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.4796,0.0212,-8.9424,-7.96890002094704,0.8673183566585454,Pathogenic,0.9964,pathogenic,-4.773,available,https://doi.org/10.1101/2022.10.22.513328 +C275M,NP_000537:p.Cys275Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.20113,0.916846752166748,2.60748,0.6056963761369943,1.904305,0.9034131880684972,Uncertain,Neutral,Neutral,Neutral,Neutral,True,0.228,0.82648,,,-0.4214,Neutral,-0.02315,,,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.5147,0.0212,-22.2302,-7.96890002094704,0.8399726243444124,Pathogenic,0.9981,pathogenic,-4.938,available,https://doi.org/10.1101/2022.10.22.513328 +C275N,NP_000537:p.Cys275Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.14767,1.0996301174163818,2.21497,0.8605338483126909,2.1813200000000004,1.5041019241563456,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,True,0.228,0.37842,,,-0.00338,Neutral,0.01875,,,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.5402,0.0212,-22.2302,-7.96890002094704,0.8694492032097283,Pathogenic,0.9995,pathogenic,-4.896,available,https://doi.org/10.1101/2022.10.22.513328 +C275P,NP_000537:p.Cys275Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.32095,1.8448549509048464,3.50782,5.112795187395529,3.9143850000000002,4.716872593697764,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,True,0.228,-0.07008,,,-0.0343,Neutral,0.00267,,,12.4,,False,12.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.98,-,-0.6088,0.0212,-22.2302,-7.96890002094704,0.8633991065754671,Pathogenic,0.9996,pathogenic,-5.016,available,https://doi.org/10.1101/2022.10.22.513328 +C275Q,NP_000537:p.Cys275Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.54786,1.3497467041015625,2.10952,0.9913677974769975,1.82869,1.2696138987384988,Uncertain,Neutral,Uncertain,Neutral,Neutral,True,0.228,0.45386,,,0.02142,Neutral,-0.02294,,,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.5642,0.0212,-22.2302,-7.96890002094704,0.8429931487764635,Pathogenic,0.9998,pathogenic,-4.914,available,https://doi.org/10.1101/2022.10.22.513328 +C275R,NP_000537:p.Cys275Arg,"hg19,17:g.7577115A>G, hg19,17:g.7673797A>G, hg38,17:g.7673797A>G",,,0.962,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376584,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.43025,1.6158015727996826,3.4,1.2721730203521169,2.4151249999999997,1.3512115101760585,Uncertain,Neutral,Uncertain,Uncertain,Neutral,True,0.228,1.03194,-0.23632,Uncertain,2.47287,Destabilizing,0.15258,-0.00945,Neutral,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.5428,0.0212,-22.2302,-7.96890002094704,0.8685728591927009,Pathogenic,0.9995,pathogenic,-4.7,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C275S,NP_000537:p.Cys275Ser,"hg19,17:g.7577114C>G, hg19,17:g.7577115A>T, hg19,17:g.7673796C>G, hg38,17:g.7673796C>G, hg38,17:g.7673797A>T",,,"0.965, 0.982","cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","960924, 376583","Uncertain significance, Conflicting classifications of pathogenicity","1, 1",,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.05456,0.2929301261901855,0.95714,1.0987811355802053,0.45128999999999997,0.5221105677901027,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.228,-1.07194,-0.0245,Uncertain,-0.02827,Neutral,-0.00641,0.07219,Neutral,12.4,,False,12.4,,neutral,neutral,neutral,DOWN,mixed_effects,neutral,False,neutral,neutral,97.98,-,-0.4813,0.0212,-22.2302,-4.46041556087988,0.8168382547942192,Pathogenic,0.9933,pathogenic,-4.21,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C275T,NP_000537:p.Cys275Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.29559,0.3883955478668213,-0.43503,0.8640320011188648,-0.86531,-0.2157789994405676,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.228,1.33968,,,1.56221,Destabilizing,-0.00129,,,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.516,0.0212,-22.2302,-4.78341883513615,0.862664846113737,Pathogenic,0.9968,pathogenic,-4.806,available,https://doi.org/10.1101/2022.10.22.513328 +C275V,NP_000537:p.Cys275Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.19816,0.0730115175247192,0.47755,0.2255047733571014,0.13969499999999999,0.013672386678550696,Neutral,Neutral,Neutral,Neutral,Neutral,True,0.228,3.8333,,,0.41038,Neutral,0.06137,,,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.5124,0.0212,-22.2302,-7.96890002094704,0.8551819140281529,Pathogenic,0.9958,pathogenic,-4.716,available,https://doi.org/10.1101/2022.10.22.513328 +C275W,NP_000537:p.Cys275Trp,"hg19,17:g.7577113A>C, hg19,17:g.7673795A>C, hg38,17:g.7673795A>C",,,0.922,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",485044,Likely pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.35558,1.1099237203598022,1.62959,0.4232166386390362,1.992585,1.389398319319518,Uncertain,Uncertain,Uncertain,Neutral,Neutral,True,0.228,7.05257,-0.46317,Uncertain,2.58838,Destabilizing,-0.12978,0.01385,Neutral,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.4876,0.0212,-22.2302,-7.96890002094704,0.864854623485108,Pathogenic,0.9994,pathogenic,-4.81,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C275Y,NP_000537:p.Cys275Tyr,"hg19,17:g.7577114C>T, hg19,17:g.7673796C>T, hg38,17:g.7673796C>T",3.186336987e-05,,0.972,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",215997,Pathogenic/Likely pathogenic,2,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.65032,1.0383706092834473,1.4119,0.8478635948195625,1.03111,0.7490917974097813,Neutral,Neutral,Uncertain,Neutral,Neutral,True,0.228,0.42654,0.28013,Neutral,3.04026,Destabilizing,0.05378,0.02065,Neutral,12.4,,False,12.4,,neutral,neutral,neutral,UP,stabilizing,neutral,False,neutral,neutral,97.98,-,-0.4938,0.0212,-22.2302,-7.96890002094704,0.843600373546457,Pathogenic,0.9996,pathogenic,-4.683,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276C,NP_000537:p.Ala276Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30414,-0.0452640056610107,0.62075,0.8468735827932511,0.462445,0.5755067913966255,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,0.49858,,Uncertain,-0.0048,Neutral,0.04101,,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,damaging,97.23,S,-0.3336,0.0749,-22.2273,-4.32255694953662,0.7431236801579275,Pathogenic,0.9743,pathogenic,-4.132,available,https://doi.org/10.1101/2022.10.22.513328 +A276D,NP_000537:p.Ala276Asp,"hg19,17:g.7577110_7577111delinsAT, hg19,17:g.7577111G>T, hg19,17:g.7673793G>T, hg38,17:g.7673792_7673793delinsAT, hg38,17:g.7673793G>T",,,0.951,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",232683,Conflicting classifications of pathogenicity,1,Uncertain significance,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,-0.064,-0.1070650815963745,-0.19592,-0.3476875874957791,-0.12996000000000002,-0.20584379374788955,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,3.07098,0.32711,Uncertain,0.55595,Neutral,1.18919,0.36523,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.4154,0.0749,-22.2273,-7.37168848391084,0.779089296744687,Pathogenic,0.9993,pathogenic,-4.498,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276E,NP_000537:p.Ala276Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.59032,-0.0041016340255737,-0.35884,-0.3420571249239651,-0.47458,-0.46618856246198254,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,1.89812,,Uncertain,0.31919,Neutral,0.89751,,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.3332,0.0749,-8.9394,-7.37168848391084,0.8670653390220142,Pathogenic,0.9987,pathogenic,-4.61,available,https://doi.org/10.1101/2022.10.22.513328 +A276F,NP_000537:p.Ala276Phe,"hg19,17:g.7577111_7577112delinsAA, hg38,17:g.7673793_7673794delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.20135,0.7388831377029419,0.31088,-0.2484840120412484,0.256115,-0.023567006020624198,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,1.60204,-0.91628,Uncertain,-1.18192,Stabilizing,-0.66538,-0.95186,Neutral,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.3837,0.0749,-22.2273,-7.62748751942468,0.8665935834863054,Pathogenic,0.9806,pathogenic,-4.62,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276G,NP_000537:p.Ala276Gly,"hg19,17:g.7577111G>C, hg19,17:g.7673793G>C, hg38,17:g.7673793G>C",,,0.930,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",185319,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.4428,0.6021643877029419,1.11395,0.57713467736564,0.778375,0.50996733868282,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,1.09376,0.41222,Uncertain,0.76769,Neutral,0.23838,0.15852,Neutral,96.5,,False,96.5,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,97.23,S,-0.3271,0.0749,-22.2273,-7.62748751942468,0.8609790103964514,Pathogenic,0.9785,pathogenic,-4.232,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276H,NP_000537:p.Ala276His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.68939,0.1845206022262573,0.21531,-0.3979695964685992,0.45235,0.14571020176570038,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,1.49578,,Uncertain,-0.10655,Neutral,-0.00222,,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.3879,0.0749,-22.2273,-7.62748751942468,0.8625555034834216,Pathogenic,0.9944,pathogenic,-4.617,available,https://doi.org/10.1101/2022.10.22.513328 +A276I,NP_000537:p.Ala276Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.1029,0.6056407690048218,0.1881,-0.1703853960538742,0.1455,-0.0337426980269371,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,0.97882,,Uncertain,-0.0161,Neutral,-0.7792,,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.3733,0.0749,-22.2273,-7.62748751942468,0.8708296571353376,Pathogenic,0.9955,pathogenic,-4.443,available,https://doi.org/10.1101/2022.10.22.513328 +A276K,NP_000537:p.Ala276Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.4016,0.4532439708709717,-0.05646,-0.1718258666648958,-0.22903,-0.2867129333324479,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,-0.45022,,Uncertain,-1.00605,Stabilizing,-0.38149,,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.4057,0.0749,-22.2273,-6.90936883801731,0.5828304348554479,Uncertain,0.9985,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +A276L,NP_000537:p.Ala276Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.02863,0.3848362565040588,0.17109,-0.5047182066750389,0.07123,-0.26667410333751945,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,0.69776,,Uncertain,-0.58938,Neutral,-0.74916,,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.378,0.0749,-22.2273,-7.62748751942468,0.8707002109512268,Pathogenic,0.9671,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +A276M,NP_000537:p.Ala276Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.07674,0.5503937602043152,0.03027,-0.1691570695739569,-0.023235000000000002,-0.12294853478697845,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,-0.06744,,Uncertain,-1.18119,Stabilizing,-0.6881,,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.3368,0.0749,-22.2273,-7.62748751942468,0.8686092729405677,Pathogenic,0.9931,pathogenic,-4.514,available,https://doi.org/10.1101/2022.10.22.513328 +A276N,NP_000537:p.Ala276Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.2542,0.1275745034217834,-0.03912,-0.1092535211360146,0.10754,0.07247323943199269,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,0.99946,,Uncertain,0.41536,Neutral,0.1076,,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.3857,0.0749,-22.2273,-7.37168848391084,0.8697210431541887,Pathogenic,0.9931,pathogenic,-4.492,available,https://doi.org/10.1101/2022.10.22.513328 +A276P,NP_000537:p.Ala276Pro,"hg19,17:g.7577112C>G, hg19,17:g.7673794C>G, hg38,17:g.7673794C>G",,,0.949,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",428893,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.12726,-0.1913684606552124,-0.07993,0.3617174221008912,-0.603595,-0.38277128894955437,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,4.34798,1.58453,Destabilizing,7.61818,Destabilizing,-0.00799,0.04622,Neutral,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.4551,0.0749,-22.2273,-7.62748751942468,0.8610490359156022,Pathogenic,0.9913,pathogenic,-4.348,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276Q,NP_000537:p.Ala276Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.30954,0.2598059773445129,-0.04116,-0.0730883128789577,-0.17535,-0.19131415643947886,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,-0.03318,,Uncertain,0.09899,Neutral,-0.08389,,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.3832,0.0749,-22.2273,-7.37168848391084,0.8535416890561107,Pathogenic,0.9881,pathogenic,-4.515,available,https://doi.org/10.1101/2022.10.22.513328 +A276R,NP_000537:p.Ala276Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.75766,0.6148788332939148,0.37075,-0.1747238734091655,-0.193455,-0.46619193670458275,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,-0.69358,,Uncertain,-0.58461,Neutral,-0.5039,,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.4164,0.0749,-22.2273,-6.1688153241086,0.442732348773676,Uncertain,0.9704,pathogenic,-4.34,available,https://doi.org/10.1101/2022.10.22.513328 +A276S,NP_000537:p.Ala276Ser,"hg19,17:g.7577112C>A, hg38,17:g.7673794C>A",,,0.850,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.21822,0.0355647802352905,0.12245,-0.0831772926923479,0.17033500000000001,0.06752135365382606,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,-0.0479,0.25694,Neutral,0.9602,Neutral,0.46819,-0.05808,Neutral,96.5,,False,96.5,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.23,S,-0.2983,0.0749,-22.2273,-3.61938748631823,0.0571987258257134,Benign,0.6879,pathogenic,-3.496,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276T,NP_000537:p.Ala276Thr,"hg19,17:g.7577112C>T, hg38,17:g.7673794C>T",,,0.928,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",827547,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.28298,0.5397863984107971,0.04082,-0.0687822425011952,0.16190000000000002,0.10709887874940241,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,0.37396,0.57897,Neutral,1.02561,Destabilizing,0.22437,-0.09539,Neutral,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.2284,0.0749,-7.3546,-1.74589151428764,0.0241303041126006,Benign,0.97,pathogenic,-3.594,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276V,NP_000537:p.Ala276Val,"hg19,17:g.7577111G>A, hg38,17:g.7673793G>A",,,0.934,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3893198,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.24902,0.5212153196334839,0.07449,-0.0537539451659291,0.16175499999999998,0.09763302741703545,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,0.93636,-0.09273,Neutral,0.002,Neutral,-0.24669,-0.25143,Neutral,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.3013,0.0749,-22.2273,-7.62748751942468,0.8621398981845383,Pathogenic,0.9902,pathogenic,-4.226,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +A276W,NP_000537:p.Ala276Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.07462,0.5764942765235901,-0.36463,-0.6662884784368156,-0.145005,-0.2958342392184078,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,1.59336,,Uncertain,-0.96665,Neutral,-0.53687,,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.3947,0.0749,-22.2273,-7.62748751942468,0.8580265128595761,Pathogenic,0.9977,pathogenic,-4.813,available,https://doi.org/10.1101/2022.10.22.513328 +A276Y,NP_000537:p.Ala276Tyr,"hg19,17:g.7577111_7577112delinsTA",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22014,0.5749101638793945,0.13265,-0.2611754279340184,0.176395,-0.020517713967009188,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.096,1.64818,,Uncertain,-0.9672,Neutral,-0.35289,,Uncertain,96.5,,False,96.5,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.23,S,-0.4029,0.0749,-22.2273,-7.62748751942468,0.8470975870481166,Pathogenic,0.994,pathogenic,-4.698,available,https://doi.org/10.1101/2022.10.22.513328 +C277A,NP_000537:p.Cys277Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01935,0.8222968578338623,-0.44252,-0.130736765324837,-0.230935,-0.0750433826624185,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,0.5239,,Uncertain,0.06752,Neutral,-0.03768,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.83,-,-0.4905,0.0212,-22.2302,-4.78540406810362,0.8648400057600738,Pathogenic,0.9938,pathogenic,-4.758,available,https://doi.org/10.1101/2022.10.22.513328 +C277D,NP_000537:p.Cys277Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.89018,0.10847008228302,0.73503,-0.0395672835081739,-0.077575,-0.46487364175408696,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,0.83324,,Uncertain,-2.69328,Stabilizing,0.24169,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.83,-,-0.5978,0.0212,-22.2302,-7.97190875216479,0.8707467756957098,Pathogenic,0.9997,pathogenic,-4.91,available,https://doi.org/10.1101/2022.10.22.513328 +C277E,NP_000537:p.Cys277Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22164,0.3300893306732178,-0.24116,-0.2990729268538006,-0.009760000000000005,-0.0387164634269003,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,0.53776,,Uncertain,-2.05424,Stabilizing,0.20976,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.5854,0.0212,-22.2302,-7.97190875216479,0.870657806878097,Pathogenic,1.0,pathogenic,-4.952,available,https://doi.org/10.1101/2022.10.22.513328 +C277F,NP_000537:p.Cys277Phe,"hg19,17:g.7577108C>A, hg19,17:g.7673790C>A, hg38,17:g.7673790C>A",,3.9791809254e-06,0.932,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458567,Conflicting classifications of pathogenicity,1,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.58063,0.2012712955474853,-1.52619,-1.2543739532585778,-1.05341,-0.9175019766292889,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,-0.42086,0.25509,Neutral,2.22822,Destabilizing,-0.56033,-0.19489,Neutral,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.4845,0.0212,-22.2302,-7.70457574756643,0.8083957364099436,Pathogenic,0.9904,pathogenic,-4.687,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C277G,NP_000537:p.Cys277Gly,"hg19,17:g.7577109A>C, hg19,17:g.7673791A>C, hg38,17:g.7673791A>C",,,0.846,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",2757236,Likely pathogenic,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.83718,1.3185328245162964,4.49626,1.0867806089065013,2.66672,0.9619803044532507,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.064,0.79696,0.15074,Neutral,0.19574,Neutral,0.04429,-0.09579,Neutral,52.8,,False,52.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.83,-,-0.483,0.0212,-22.2302,-7.97190875216479,0.8693743415061225,Pathogenic,0.9972,pathogenic,-4.766,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C277H,NP_000537:p.Cys277His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.13395,0.3577479124069214,-1.67483,-0.7727320147144057,-0.90439,-0.45334100735720284,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,-0.16784,,Uncertain,2.29536,Destabilizing,-0.49046,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.5962,0.0212,-22.2302,-7.70457574756643,0.867215154591214,Pathogenic,0.9994,pathogenic,-4.84,available,https://doi.org/10.1101/2022.10.22.513328 +C277I,NP_000537:p.Cys277Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15236,0.7359406352043152,-0.36633,-1.115510671073458,-0.259345,-0.633935335536729,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,-0.0389,,Uncertain,-0.03708,Neutral,-0.02281,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.5144,0.0212,-22.2302,-7.54819596467128,0.8691365152985879,Pathogenic,0.9977,pathogenic,-4.951,available,https://doi.org/10.1101/2022.10.22.513328 +C277K,NP_000537:p.Cys277Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.11292,1.0095281600952148,-0.00068,-0.1336261833221907,0.05612,-0.010353091661095347,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.064,-0.28072,,Uncertain,1.18807,Destabilizing,-0.38752,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.586,0.0212,-22.2302,-7.97190875216479,0.8675805980733972,Pathogenic,1.0,pathogenic,-4.942,available,https://doi.org/10.1101/2022.10.22.513328 +C277L,NP_000537:p.Cys277Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.67477,0.3332715630531311,-0.93639,-1.3639032162896574,-0.80558,-1.0193366081448287,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,-0.18372,,Uncertain,-0.03733,Neutral,0.03733,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.5474,0.0212,-22.2302,-7.16571991800992,0.8192528359533231,Pathogenic,0.9962,pathogenic,-4.748,available,https://doi.org/10.1101/2022.10.22.513328 +C277M,NP_000537:p.Cys277Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.5977,0.4768296480178833,-0.4483,-0.9761604250044064,-0.523,-0.7869302125022032,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,-0.34154,,Uncertain,-0.60768,Neutral,-0.05692,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.5147,0.0212,-22.2302,-7.54819596467128,0.8695825992142854,Pathogenic,0.9974,pathogenic,-4.974,available,https://doi.org/10.1101/2022.10.22.513328 +C277N,NP_000537:p.Cys277Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15518,0.1975862979888916,-1.07483,-0.3420451410832825,-0.615005,-0.24861257054164126,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,0.19912,,Uncertain,-0.84886,Neutral,0.06035,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.5402,0.0212,-22.2302,-7.97190875216479,0.7881311698230675,Pathogenic,0.9989,pathogenic,-4.658,available,https://doi.org/10.1101/2022.10.22.513328 +C277P,NP_000537:p.Cys277Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.22511,2.0991334915161133,5.44354,2.7721284836895164,3.3343249999999998,1.9986192418447581,Uncertain,Uncertain,Destabilizing,Destabilizing,Neutral,False,0.064,0.31126,,Uncertain,0.06572,Neutral,-0.02066,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.83,-,-0.6088,0.0212,-22.2302,-7.97190875216479,0.8708173629933158,Pathogenic,0.9995,pathogenic,-4.958,available,https://doi.org/10.1101/2022.10.22.513328 +C277Q,NP_000537:p.Cys277Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.57644,0.6312585473060608,-0.63605,-0.4549875898452027,-0.029805000000000026,0.06072620507739862,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,0.04084,,Uncertain,0.7267,Neutral,0.09208,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.5642,0.0212,-22.2302,-7.97190875216479,0.8568193959087241,Pathogenic,0.9999,pathogenic,-4.984,available,https://doi.org/10.1101/2022.10.22.513328 +C277R,NP_000537:p.Cys277Arg,"hg19,17:g.7577109A>G, hg38,17:g.7673791A>G",,,0.889,"COSMIC,ClinVar,saturation_mutlist",421804,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.26083,1.0087971687316897,-0.45816,-0.6825359840709289,-0.098665,-0.21085299203546443,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.064,-0.39042,-0.70278,Neutral,1.09823,Destabilizing,-0.40531,-0.18461,Neutral,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.5428,0.0212,-22.2302,-7.97190875216479,0.8673125779722324,Pathogenic,0.9996,pathogenic,-4.82,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C277S,NP_000537:p.Cys277Ser,"hg19,17:g.7577108C>G, hg19,17:g.7577109A>T, hg38,17:g.7673790C>G",,,"0.894, 0.936","cBioPortal,COSMIC,ClinVar,saturation_mutlist",655556,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.32342,0.6537643074989319,0.40476,0.1064997136357087,0.36409,0.21495985681785434,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,0.35738,-0.35017,Neutral,0.15981,Neutral,-0.00969,0.00759,Neutral,52.8,,False,52.8,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.83,-,-0.4813,0.0212,-22.2302,-3.66742459155775,0.0938480296448164,Benign,0.9837,pathogenic,-4.213,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C277T,NP_000537:p.Cys277Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.15238,0.4773451089859009,0.2102,-0.2263282209787398,0.18129,-0.03697411048936991,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,-0.46278,,Uncertain,0.67159,Neutral,0.03599,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.516,0.0212,-22.2302,-4.71524399892311,0.8254853971127278,Pathogenic,0.9978,pathogenic,-4.725,available,https://doi.org/10.1101/2022.10.22.513328 +C277V,NP_000537:p.Cys277Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14297,0.7645379304885864,-0.45306,-0.8861244338060553,-0.155045,-0.37157721690302764,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,-0.25534,,Uncertain,-0.23696,Neutral,0.0284,,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.5124,0.0212,-22.2302,-7.54819596467128,0.8545103650099473,Pathogenic,0.9933,pathogenic,-4.754,available,https://doi.org/10.1101/2022.10.22.513328 +C277W,NP_000537:p.Cys277Trp,"hg19,17:g.7577107A>C, hg19,17:g.7673789A>C, hg38,17:g.7673789A>C",,,0.875,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1762926,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.29378,0.1713780164718628,-0.59082,-1.2722980388833875,-0.4423,-0.7830390194416937,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,0.53116,0.67358,Neutral,3.41761,Destabilizing,-1.24465,-0.13733,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.4198,0.0212,-8.9424,-7.70457574756643,0.7870712756526672,Pathogenic,0.9979,pathogenic,-4.78,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +C277Y,NP_000537:p.Cys277Tyr,"hg19,17:g.7577108C>T, hg38,17:g.7673790C>T",,0.0,0.940,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",185722,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.38957,0.1629798412322998,-1.74524,-0.9008397401918532,-1.067405,-0.6452048700959266,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.064,-0.18368,0.41881,Neutral,1.19124,Destabilizing,-1.89786,-0.64547,Uncertain,52.8,,False,52.8,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.83,-,-0.4938,0.0212,-22.2302,-7.70457574756643,0.870614235976073,Pathogenic,0.9986,pathogenic,-4.676,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278A,NP_000537:p.Pro278Ala,"hg19,17:g.7577106G>C, hg19,17:g.7673788G>C, hg38,17:g.7673788G>C",,,0.958,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376645,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.38073,2.2910797595977783,1.18265,-0.1294981492765762,1.7816899999999998,1.1256159253617117,Uncertain,Uncertain,Destabilizing,Neutral,Neutral,False,0.027,-0.04876,-0.08174,Neutral,-0.04487,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,H,-0.3237,0.0423,-22.2302,-7.65902909566732,0.8704820659871179,Pathogenic,0.9934,pathogenic,-4.24,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278C,NP_000537:p.Pro278Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.24123,1.6839460134506226,3.96905,0.8575548220668561,4.1051400000000005,2.549392411033428,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.027,0.04082,,,-0.06147,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.83,H,-0.3564,0.0423,-22.2302,-7.65902909566732,0.8700050775606749,Pathogenic,0.9992,pathogenic,-4.498,available,https://doi.org/10.1101/2022.10.22.513328 +P278D,NP_000537:p.Pro278Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.00905,2.703500270843506,7.0051,3.0286778972051507,8.007075,6.018863948602576,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,0.42428,,,-0.27676,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.83,H,-0.3823,0.0423,-22.2302,-7.924781724694,0.8628138570051465,Pathogenic,0.9999,pathogenic,-4.656,available,https://doi.org/10.1101/2022.10.22.513328 +P278E,NP_000537:p.Pro278Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.62996,2.3593859672546387,8.28265,3.815303698312011,8.956305,6.722631849156006,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,0.2679,,,-0.2444,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.83,H,-0.3661,0.0423,-22.2302,-7.924781724694,0.8491091612697397,Pathogenic,0.9996,pathogenic,-4.596,available,https://doi.org/10.1101/2022.10.22.513328 +P278F,NP_000537:p.Pro278Phe,"hg19,17:g.7577105_7577106delinsAA, hg19,17:g.7673787_7673788delinsAA, hg38,17:g.7673787_7673788delinsAA",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,33.46192,1.8608958721160889,19.03027,4.597894654819724,26.246095,19.029907327409862,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.027,0.27328,-0.42926,Neutral,0.02255,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.83,H,-0.3849,0.0423,-22.2302,-7.924781724694,0.8699998523803973,Pathogenic,0.9999,pathogenic,-4.449,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278G,NP_000537:p.Pro278Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.78392,2.6032750606536865,3.59082,1.865654547000004,3.68737,2.824787273500002,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.027,-0.05194,,,-0.0445,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,H,-0.3381,0.0423,-22.2302,-7.924781724694,0.845427609497148,Pathogenic,0.9989,pathogenic,-4.53,available,https://doi.org/10.1101/2022.10.22.513328 +P278H,NP_000537:p.Pro278His,"hg19,17:g.7577105G>T, hg19,17:g.7673787G>T, hg38,17:g.7673787G>T",,,0.950,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376646,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,28.1508,2.704637289047241,24.99252,4.592481282107858,26.57166,16.37164064105393,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,-0.10474,0.04266,Neutral,0.04575,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.83,H,-0.3625,0.0423,-22.2302,-7.924781724694,0.864473108403625,Pathogenic,0.9993,pathogenic,-4.4,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278I,NP_000537:p.Pro278Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.13144,2.054032325744629,4.3915,1.1457708982882746,7.261469999999999,5.638605449144137,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.027,0.00816,,,-0.05035,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.83,H,-0.3679,0.0423,-22.2302,-7.65902909566732,0.8603459980114134,Pathogenic,0.9994,pathogenic,-4.302,available,https://doi.org/10.1101/2022.10.22.513328 +P278K,NP_000537:p.Pro278Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.48278,2.377351760864258,18.3102,6.413102488912014,15.39649,9.447941244456008,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,-0.14978,,,0.06765,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.83,H,-0.3578,0.0423,-22.2302,-7.924781724694,0.8668885184953741,Pathogenic,0.9995,pathogenic,-4.542,available,https://doi.org/10.1101/2022.10.22.513328 +P278L,NP_000537:p.Pro278Leu,"hg19,17:g.7577105G>A, hg19,17:g.7673787G>A, hg38,17:g.7673787G>A",,,0.940,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",232497,Pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.67109,1.9425995349884035,6.7415,1.710554648867055,8.706295,6.190822324433527,Destabilizing,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.027,0.13318,0.41877,Neutral,0.03248,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.83,H,-0.3047,0.0423,-8.9424,-5.65653065547344,0.3363015091277291,Uncertain,0.9972,pathogenic,-3.952,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278M,NP_000537:p.Pro278Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,10.47641,2.0388190746307373,6.34286,1.7833169105515891,8.409635,6.129863455275794,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.027,0.12192,,,0.04889,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.83,H,-0.3234,0.0423,-22.2302,-7.65902909566732,0.8476373495340948,Pathogenic,0.9997,pathogenic,-4.522,available,https://doi.org/10.1101/2022.10.22.513328 +P278N,NP_000537:p.Pro278Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.32863,2.821183443069458,5.21395,1.6565864998229405,6.7712900000000005,4.992608249911471,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.027,0.04274,,,-0.03945,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.83,H,-0.3505,0.0423,-22.2302,-7.924781724694,0.8679322680569956,Pathogenic,0.9998,pathogenic,-4.62,available,https://doi.org/10.1101/2022.10.22.513328 +P278Q,NP_000537:p.Pro278Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.91857,2.4793074131011963,6.5102,2.845116685748444,8.214385,6.381843342874222,Destabilizing,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.027,0.03112,,,0.04946,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.83,H,-0.3522,0.0423,-22.2302,-7.924781724694,0.8611188206831677,Pathogenic,0.9996,pathogenic,-4.352,available,https://doi.org/10.1101/2022.10.22.513328 +P278R,NP_000537:p.Pro278Arg,"hg19,17:g.7577105G>C, hg19,17:g.7673787G>C, hg38,17:g.7673787G>C",,,0.951,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376644,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,16.27614,2.432934045791626,13.98571,5.394668692371276,15.130925000000001,10.835404346185639,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,-0.30776,0.22486,Neutral,0.47491,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.83,H,-0.3936,0.0423,-22.2302,-7.924781724694,0.87078813850924,Pathogenic,0.9968,pathogenic,-4.502,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278S,NP_000537:p.Pro278Ser,"hg19,17:g.7577106G>A, hg19,17:g.7673788G>A, hg38,17:g.7673788G>A",,,0.963,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376642,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,2.83418,2.557756185531616,3.69082,1.0263047716840523,3.2625,1.9302423858420261,Uncertain,Uncertain,Destabilizing,Destabilizing,Neutral,False,0.027,-0.08398,-0.07008,Neutral,-0.06592,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.83,H,-0.2556,0.0423,-8.9424,-5.02543687785345,0.3959218596441421,Uncertain,0.9988,pathogenic,-4.005,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278T,NP_000537:p.Pro278Thr,"hg19,17:g.7577106G>T, hg19,17:g.7673788G>T, hg38,17:g.7673788G>T",,,0.954,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376643,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.41981,2.676314353942871,3.18844,0.7200266652839296,3.304125,2.069918332641965,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.027,0.01738,-0.068,Neutral,-0.06323,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.83,H,-0.3356,0.0423,-22.2302,-7.65902909566732,0.8705672489414769,Pathogenic,0.9974,pathogenic,-4.266,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278V,NP_000537:p.Pro278Val,"hg19,17:g.7577105_7577106delinsAC, hg38,17:g.7673787_7673788delinsAC",,,,"cBioPortal,ClinVar,saturation_mutlist",3764814,,,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.55725,2.2949280738830566,3.87449,0.0077436575899697,4.71587,2.7824968287949847,Destabilizing,Uncertain,Destabilizing,Destabilizing,Uncertain,False,0.027,0.009,0.11028,Neutral,-0.05789,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.83,H,-0.3233,0.0423,-22.2302,-7.65902909566732,0.8663365565431582,Pathogenic,0.9982,pathogenic,-4.322,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +P278W,NP_000537:p.Pro278Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,49.82074,2.1848673820495605,148.25034,5.941978267503596,99.03554,27.881359133751797,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,0.23434,,,0.03062,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.83,H,-0.3974,0.0423,-22.2302,-7.924781724694,0.869005497673309,Pathogenic,0.9998,pathogenic,-4.684,available,https://doi.org/10.1101/2022.10.22.513328 +P278Y,NP_000537:p.Pro278Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,30.89392,2.0231990814208984,21.46122,5.635787020646736,26.177570000000003,18.26485351032337,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,0.53694,,,0.01235,Neutral,,,,0.3,,False,0.3,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.83,H,-0.3858,0.0423,-22.2302,-7.924781724694,0.861155409223958,Pathogenic,0.9998,pathogenic,-4.412,available,https://doi.org/10.1101/2022.10.22.513328 +G279A,NP_000537:p.Gly279Ala,"hg19,17:g.7577102C>G",,,0.907,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.26999,1.1068304777145386,2.80034,3.932012198016744,3.035165,3.6010010990083723,Uncertain,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,-0.005,0.15825,Neutral,0.14126,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.3797,0.0423,-22.2302,-6.08115856665018,0.8128160749638212,Pathogenic,0.9586,pathogenic,-4.048,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G279C,NP_000537:p.Gly279Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,8.19336,1.027845025062561,6.20816,6.851992626788093,7.200760000000001,7.522676313394046,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,-0.0442,,,0.14073,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.4395,0.0423,-22.2302,-6.48575972066515,0.6938623673270732,Pathogenic,0.9923,pathogenic,-4.129,available,https://doi.org/10.1101/2022.10.22.513328 +G279D,NP_000537:p.Gly279Asp,"hg19,17:g.7577101_7577102delinsAT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.01374,1.5127177238464355,10.57585,9.172012131322171,11.294795,10.592876065661086,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,0.01422,0.01769,Neutral,0.08113,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.44,0.0423,-22.2302,-7.59509316699625,0.8664744457816115,Pathogenic,0.9991,pathogenic,-4.419,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G279E,NP_000537:p.Gly279Glu,"hg19,17:g.7577101_7577102delinsTT, hg19,17:g.7577102C>T, hg19,17:g.7673783_7673784delinsTT, hg19,17:g.7673784C>T, hg38,17:g.7673783_7673784delinsTT, hg38,17:g.7673784C>T",,,0.907,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",419454,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,11.98776,1.778258204460144,13.87483,10.450627971515742,12.931294999999999,11.21919398575787,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,0.07698,0.16347,Neutral,-0.01656,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.4393,0.0423,-22.2302,-7.59509316699625,0.8672199239531324,Pathogenic,0.9986,pathogenic,-4.424,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G279F,NP_000537:p.Gly279Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,19.76168,1.0749759674072266,23.61088,9.635615855439369,21.68628,14.698647927719684,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,0.01164,,,0.47109,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.4776,0.0423,-22.2302,-7.24613300466929,0.8688080356555441,Pathogenic,0.9979,pathogenic,-4.565,available,https://doi.org/10.1101/2022.10.22.513328 +G279H,NP_000537:p.Gly279His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,23.48022,1.4423896074295044,17.50816,9.858099959343589,20.49419,16.669159979671793,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,-0.02748,,,1.0279,Destabilizing,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.4523,0.0423,-22.2302,-7.06864745155791,0.483925338210015,Uncertain,0.9996,pathogenic,-4.354,available,https://doi.org/10.1101/2022.10.22.513328 +G279I,NP_000537:p.Gly279Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,15.86588,1.4654169082641602,12.48265,10.03500540256278,14.174265,12.95044270128139,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,-0.01024,,,0.36376,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.5233,0.0423,-22.2302,-7.06713682250735,0.8707944440096302,Pathogenic,0.996,pathogenic,-4.608,available,https://doi.org/10.1101/2022.10.22.513328 +G279K,NP_000537:p.Gly279Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,17.6468,1.5826045274734497,22.47619,11.193923376579278,20.061495,14.420361688289638,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,-0.09306,,,0.61369,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.4722,0.0423,-22.2302,-5.58710387886044,0.2107351379708033,Benign,0.9992,pathogenic,-3.683,available,https://doi.org/10.1101/2022.10.22.513328 +G279L,NP_000537:p.Gly279Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,18.49082,1.4175946712493896,15.32245,9.546843632929978,16.906635,14.018831816464989,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,-0.03216,,,0.2161,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.4915,0.0423,-22.2302,-6.7001957639708,0.6763707451042147,Uncertain,0.9962,pathogenic,-4.215,available,https://doi.org/10.1101/2022.10.22.513328 +G279M,NP_000537:p.Gly279Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,11.5125,1.2760372161865234,14.6,9.367950153472204,13.056249999999999,10.440225076736102,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,-0.02676,,,0.15142,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.4297,0.0423,-22.2302,-7.06713682250735,0.851291756465724,Pathogenic,0.9982,pathogenic,-4.485,available,https://doi.org/10.1101/2022.10.22.513328 +G279N,NP_000537:p.Gly279Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.50028,1.4912105798721311,8.20544,8.099539676658738,10.35286,10.29990983832937,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,0.04458,,,0.49453,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.4403,0.0423,-22.2302,-7.59509316699625,0.8705203265100196,Pathogenic,0.9986,pathogenic,-4.231,available,https://doi.org/10.1101/2022.10.22.513328 +G279P,NP_000537:p.Gly279Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.04566,1.53643000125885,9.47551,11.100809036461468,6.260585,7.073234518230734,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,0.03562,,,0.21069,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.5374,0.0423,-22.2302,-7.8590713392407,0.8704625588550596,Pathogenic,0.9982,pathogenic,-4.608,available,https://doi.org/10.1101/2022.10.22.513328 +G279Q,NP_000537:p.Gly279Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.09826,1.5492358207702637,13.05306,9.581259161886658,12.57566,10.83975958094333,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,0.0135,,,0.32866,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.4432,0.0423,-22.2302,-7.43985307304706,0.7808426013179424,Pathogenic,0.9985,pathogenic,-4.23,available,https://doi.org/10.1101/2022.10.22.513328 +G279R,NP_000537:p.Gly279Arg,"hg19,17:g.7577103C>G, hg19,17:g.7577103C>T, hg19,17:g.7673785C>G, hg19,17:g.7673785C>T, hg38,17:g.7673785C>G, hg38,17:g.7673785C>T",,,0.896,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458568,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,17.16708,1.4962893724441528,30.93061,10.648701013745304,24.048845,13.90789050687265,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,-0.13994,-0.07751,Neutral,0.76913,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.3885,0.0423,-8.9424,-6.15827489133228,0.0819283186199024,Benign,0.9973,pathogenic,-3.804,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G279S,NP_000537:p.Gly279Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,7.52174,1.308724284172058,5.13707,5.756828296247732,6.3294049999999995,6.639284148123866,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,-0.00932,,,0.24276,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.3856,0.0423,-22.2302,-5.56155463426553,0.3353339507516591,Uncertain,0.963,pathogenic,-3.826,available,https://doi.org/10.1101/2022.10.22.513328 +G279T,NP_000537:p.Gly279Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.00826,1.2924716472625732,6.88639,7.884690289979086,9.447325,9.946475144989543,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,0.0066,,,0.32652,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.4625,0.0423,-22.2302,-5.95161849905743,0.5147979977836531,Uncertain,0.9901,pathogenic,-4.136,available,https://doi.org/10.1101/2022.10.22.513328 +G279V,NP_000537:p.Gly279Val,"hg19,17:g.7577102C>A, hg38,17:g.7673783_7673784delinsTA, hg38,17:g.7673784C>A",,,0.937,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1434495,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,12.39092,1.3674049377441406,7.05442,8.680135518835373,9.72267,10.535527759417686,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,0.0313,-0.11396,Neutral,0.34006,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.4665,0.0423,-22.2302,-6.24577971419134,0.8350852190749557,Pathogenic,0.9895,pathogenic,-4.312,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G279W,NP_000537:p.Gly279Trp,"hg19,17:g.7577103C>A, hg19,17:g.7673785C>A, hg38,17:g.7673785C>A",,,0.930,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",4530243,,,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,23.93174,1.3005071878433228,41.1085,10.056698416385489,32.52012,16.994219208192746,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,0.18046,-0.25705,Neutral,1.28288,Destabilizing,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.4095,0.0423,-8.9424,-7.24613300466929,0.8478285313501481,Pathogenic,0.9965,pathogenic,-4.474,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +G279Y,NP_000537:p.Gly279Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,19.22612,1.1987295150756836,30.2551,10.126084892025426,24.74061,14.676102446012713,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.012,0.03178,,,0.73917,Neutral,,,,0.0,,False,0.0,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.02,H,-0.478,0.0423,-22.2302,-7.24613300466929,0.8687441905495304,Pathogenic,0.9979,pathogenic,-4.63,available,https://doi.org/10.1101/2022.10.22.513328 +R280A,NP_000537:p.Arg280Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.05086,0.1624056100845337,0.77483,0.7590735946267415,0.361985,0.35410679731337075,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.91306,,Uncertain,3.10863,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.4079,0.0212,-22.2302,-7.93668764215011,0.8637578640249548,Pathogenic,0.9997,pathogenic,-4.694,available,https://doi.org/10.1101/2022.10.22.513328 +R280C,NP_000537:p.Arg280Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.90121,-0.1404386758804321,1.63946,1.4379184688899176,1.270335,1.1695642344449588,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.7109,,Uncertain,3.01901,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.4167,0.0212,-22.2302,-7.93668764215011,0.8562645338147119,Pathogenic,0.9993,pathogenic,-4.437,available,https://doi.org/10.1101/2022.10.22.513328 +R280D,NP_000537:p.Arg280Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.64182,0.3427063226699829,1.41599,0.771801454024944,1.028905,0.7068107270124719,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,2.06744,,Uncertain,2.96596,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.4989,0.0212,-22.2302,-7.93668764215011,0.8664820742787178,Pathogenic,0.9991,pathogenic,-4.851,available,https://doi.org/10.1101/2022.10.22.513328 +R280E,NP_000537:p.Arg280Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.1574,0.2192804217338562,1.04354,0.5085492861743026,0.60047,0.3329746430871513,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.98246,,Uncertain,3.01195,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.4442,0.0212,-22.2302,-7.93668764215011,0.8644428520089446,Pathogenic,0.9966,pathogenic,-4.818,available,https://doi.org/10.1101/2022.10.22.513328 +R280F,NP_000537:p.Arg280Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01945,0.0510888695716857,0.74456,0.0488147642838865,0.382005,0.03413238214194325,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.77246,,Uncertain,2.48038,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.53,H,-0.44,0.0212,-22.2302,-7.93668764215011,0.8687626312560728,Pathogenic,0.9998,pathogenic,-4.74,available,https://doi.org/10.1101/2022.10.22.513328 +R280G,NP_000537:p.Arg280Gly,"hg19,17:g.7577100T>C, hg19,17:g.7673782T>C, hg38,17:g.7673782T>C",,,0.924,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376658,Conflicting classifications of pathogenicity,1,,,Tier II - Potential,0,P53 DNA-binding domain (PF00870),2.60.40.720,0.81638,1.158726930618286,2.0085,1.7908768872675311,1.4124400000000001,1.3036284436337655,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.006,1.89102,1.44012,Destabilizing,3.2148,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.4432,0.0212,-22.2302,-7.93668764215011,0.8646735653565806,Pathogenic,0.9989,pathogenic,-4.627,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280H,NP_000537:p.Arg280His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.07855,0.1759582757949829,0.97109,0.303159949969658,0.44627,0.112304974984829,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.67528,,Uncertain,2.78953,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.3776,0.0212,-22.2302,-7.93668764215011,0.8696509098230322,Pathogenic,0.9973,pathogenic,-4.396,available,https://doi.org/10.1101/2022.10.22.513328 +R280I,NP_000537:p.Arg280Ile,"hg19,17:g.7577098_7577099delinsAA, hg19,17:g.7577099C>A, hg19,17:g.7673781C>A, hg38,17:g.7673781C>A",,,0.942,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",161517,Conflicting classifications of pathogenicity,1,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15635,-0.4986691474914551,0.80476,-0.1041996993579164,0.324205,-0.1302748496789582,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.8417,1.43167,Destabilizing,3.14112,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.4373,0.0212,-22.2302,-7.93668764215011,0.8479031452221295,Pathogenic,0.9996,pathogenic,-4.721,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280K,NP_000537:p.Arg280Lys,"hg19,17:g.7577099C>T, hg19,17:g.7577099_7577101delinsTTT, hg19,17:g.7673781C>T, hg38,17:g.7673781C>T",,,0.935,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376657,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.20173,-0.0003005266189575,1.11565,0.5563456121330279,0.65869,0.37903780606651394,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.34928,0.96647,Uncertain,3.1326,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.53,H,-0.2981,0.0212,-22.2302,-4.76455912194511,0.8531094475552152,Pathogenic,0.9936,pathogenic,-4.259,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280L,NP_000537:p.Arg280Leu,"hg19,17:g.7577098_7577100delinsGAG, hg38,17:g.7673780_7673782delinsGAG",,,,"ClinVar,saturation_mutlist",1042468,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.15777,-0.0441113114356994,0.31769,-0.222553017834387,0.07995999999999999,-0.1901615089171935,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.85934,0.74792,Uncertain,2.7845,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.4103,0.0212,-22.2302,-7.93668764215011,0.8613757826851565,Pathogenic,0.9988,pathogenic,-4.524,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280M,NP_000537:p.Arg280Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.07377,0.1507095694541931,0.9915,0.29518722054092,0.532635,0.18447861027046,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.7269,,Uncertain,2.53558,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.3762,0.0212,-22.2302,-7.93668764215011,0.8584787270419894,Pathogenic,0.9999,pathogenic,-4.642,available,https://doi.org/10.1101/2022.10.22.513328 +R280N,NP_000537:p.Arg280Asn,"hg19,17:g.7577098_7577099delinsGT",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.0819,0.453295886516571,1.48571,0.6337739332230748,0.7838050000000001,0.3578369666115374,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.89258,0.84869,Uncertain,2.9437,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.4228,0.0212,-22.2302,-7.93668764215011,0.8091210020521968,Pathogenic,0.9994,pathogenic,-4.71,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280P,NP_000537:p.Arg280Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.37441,1.4555317163467407,4.33605,2.544701091313418,1.48082,0.5851455456567091,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.006,1.89328,1.14463,Destabilizing,3.49378,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.55,0.0212,-22.2302,-7.93668764215011,0.8594415802973296,Pathogenic,0.9992,pathogenic,-4.611,available,https://doi.org/10.1101/2022.10.22.513328 +R280Q,NP_000537:p.Arg280Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.2902,0.1554234623908996,1.08707,0.7532026045264917,0.398435,0.23150130226324583,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,2.00788,,Uncertain,3.24462,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.3826,0.0212,-22.2302,-7.93668764215011,0.8694796503438023,Pathogenic,0.9983,pathogenic,-4.437,available,https://doi.org/10.1101/2022.10.22.513328 +R280S,NP_000537:p.Arg280Ser,"hg19,17:g.7577098T>A, hg19,17:g.7577098T>G, hg19,17:g.7673780T>A, hg19,17:g.7673780T>G, hg38,17:g.7673780T>A, hg38,17:g.7673780T>G",,,0.878,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","988616, 634747","Conflicting classifications of pathogenicity, Pathogenic/Likely pathogenic","1, 2",,,Tier I - Strong,0,P53 DNA-binding domain (PF00870),2.60.40.720,0.56727,0.3133604526519775,1.57823,1.03000264372641,1.07275,0.7986363218632051,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.89304,1.41473,Destabilizing,3.08783,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.3406,0.0212,-8.9424,-7.93668764215011,0.8694397785436389,Pathogenic,0.9997,pathogenic,-4.557,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280T,NP_000537:p.Arg280Thr,"hg19,17:g.7577099C>G, hg19,17:g.7673781C>G, hg38,17:g.7673781C>G",,,0.940,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12368,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35007,0.3987866640090942,1.56054,0.6819814469083126,0.9553050000000001,0.5160257234541563,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.93026,1.07844,Destabilizing,3.09087,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.4128,0.0212,-22.2302,-7.93668764215011,0.8429028653017477,Pathogenic,0.9997,pathogenic,-4.662,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R280V,NP_000537:p.Arg280Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.33275,-0.1876007318496704,0.8085,0.0103497293609572,0.5706249999999999,0.1715498646804786,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.83484,,Uncertain,3.18497,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,96.53,H,-0.4244,0.0212,-22.2302,-7.93668764215011,0.8623034919482359,Pathogenic,0.9997,pathogenic,-4.761,available,https://doi.org/10.1101/2022.10.22.513328 +R280W,NP_000537:p.Arg280Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.25787,0.1688917875289917,0.97483,-0.2672751005139651,0.61635,-0.004702550256982546,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.7864,,Uncertain,2.50658,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.53,H,-0.4256,0.0212,-22.2302,-7.93668764215011,0.8606007292691373,Pathogenic,0.9946,pathogenic,-4.562,available,https://doi.org/10.1101/2022.10.22.513328 +R280Y,NP_000537:p.Arg280Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.17342,-0.0191872119903564,0.59864,0.1702795775122018,0.38603,0.1718497887561009,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.006,1.7722,,Uncertain,2.53342,Destabilizing,,,Uncertain,68.4,,False,68.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.53,H,-0.4293,0.0212,-22.2302,-7.93668764215011,0.8671597521678513,Pathogenic,0.9991,pathogenic,-4.657,available,https://doi.org/10.1101/2022.10.22.513328 +D281A,NP_000537:p.Asp281Ala,"hg19,17:g.7577096T>G, hg19,17:g.7673778T>G, hg38,17:g.7673778T>G",,,0.977,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376589,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.08332,0.8905982971191406,1.69218,0.4338237223873226,0.88775,0.25857186119366127,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,0.25292,0.46268,Neutral,1.34716,Destabilizing,,,,10.9,,False,10.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.06,H,-0.3368,0.1284,-22.2302,-7.47190388453418,0.8708607545954328,Pathogenic,0.9997,pathogenic,-4.602,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281C,NP_000537:p.Asp281Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.58273,0.6754913926124573,2.09218,1.278294595907913,1.3374549999999998,0.9305122979539565,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.007,-0.37558,,,1.31405,Destabilizing,,,,10.9,,False,10.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,damaging,97.06,H,-0.3783,0.1284,-22.2302,-7.47190388453418,0.8646788346345183,Pathogenic,0.9999,pathogenic,-4.604,available,https://doi.org/10.1101/2022.10.22.513328 +D281E,NP_000537:p.Asp281Glu,"hg19,17:g.7577095G>C, hg19,17:g.7577095G>T, hg19,17:g.7673777G>C, hg19,17:g.7673777G>T, hg38,17:g.7673777G>C, hg38,17:g.7673777G>T",,,0.909,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","406568, 376587","Pathogenic/Likely pathogenic, Conflicting classifications of pathogenicity","2, 1","Oncogenic, Oncogenic","1, 1",Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,0.9764,0.1575815677642822,1.02993,0.56855568032348,1.003165,0.77247784016174,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,-0.50284,0.053,Neutral,-0.42108,Neutral,,,,10.9,,False,10.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.06,H,-0.2059,0.1284,-7.3575,-2.79266959541697,0.8605889695961217,Pathogenic,0.9991,pathogenic,-4.204,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281F,NP_000537:p.Asp281Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.6582,1.224318027496338,1.37517,-0.0246527434942722,0.358485,-0.3414263717471361,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.007,0.1307,,,0.08321,Neutral,,,,10.9,,False,10.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.06,H,-0.437,0.1284,-22.2302,-6.86978097273434,0.8698819004403927,Pathogenic,0.9996,pathogenic,-4.808,available,https://doi.org/10.1101/2022.10.22.513328 +D281G,NP_000537:p.Asp281Gly,"hg19,17:g.7577096T>C, hg19,17:g.7673778T>C, hg38,17:g.7673778T>C",,,0.974,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141141,Pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.39521,1.7114830017089844,3.69082,2.0233859461283283,2.543015,1.7092979730641642,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.007,0.4715,0.52606,Neutral,1.48028,Destabilizing,,,,10.9,,False,10.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.06,H,-0.348,0.1284,-22.2302,-5.98985813599738,0.7245715624970708,Pathogenic,0.9995,pathogenic,-4.52,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281H,NP_000537:p.Asp281His,"hg19,17:g.7577097C>G, hg19,17:g.7673779C>G, hg38,17:g.7673779C>G",,,0.961,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376588,Pathogenic/Likely pathogenic,2,,,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,-0.18853,0.992379367351532,1.52381,0.2191910325424684,0.66764,0.015330516271234204,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,1.98374,0.58633,Uncertain,0.00518,Neutral,,,,10.9,,False,10.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.06,H,-0.2703,0.1284,-7.3575,-3.99773447527279,0.0556336420513378,Benign,0.9993,pathogenic,-4.123,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281I,NP_000537:p.Asp281Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.70379,0.9976092576980592,1.97823,0.2515448700370837,0.6372199999999999,-0.22612256498145816,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,2.21718,,,1.0246,Destabilizing,,,,10.9,,False,10.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.06,H,-0.4292,0.1284,-22.2302,-7.73122410772527,0.8640388448762604,Pathogenic,0.9998,pathogenic,-4.779,available,https://doi.org/10.1101/2022.10.22.513328 +D281K,NP_000537:p.Asp281Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.64087,1.6740608215332031,2.97891,0.948934675053864,1.80989,0.794902337526932,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.007,0.62958,,,1.62196,Destabilizing,,,,10.9,,False,10.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.06,H,-0.4076,0.1284,-22.2302,-7.73122410772527,0.8665698885078401,Pathogenic,0.9994,pathogenic,-4.708,available,https://doi.org/10.1101/2022.10.22.513328 +D281L,NP_000537:p.Asp281Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.67662,1.1130402088165283,2.02109,0.0320039679426192,0.672235,-0.3223080160286904,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.007,1.25638,,,0.89843,Neutral,,,,10.9,,False,10.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.06,H,-0.355,0.1284,-8.9424,-7.73122410772527,0.8685492752817807,Pathogenic,0.9996,pathogenic,-4.69,available,https://doi.org/10.1101/2022.10.22.513328 +D281M,NP_000537:p.Asp281Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.75267,1.117493987083435,2.32109,0.3251444002135339,0.78421,-0.21376279989323302,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.007,-0.21302,,,0.05653,Neutral,,,,10.9,,False,10.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.06,H,-0.3616,0.1284,-22.2302,-7.73122410772527,0.8665544628478621,Pathogenic,1.0,pathogenic,-4.806,available,https://doi.org/10.1101/2022.10.22.513328 +D281N,NP_000537:p.Asp281Asn,"hg19,17:g.7577097C>T, hg19,17:g.7673779C>T, hg38,17:g.7673779C>T",,3.9771552204e-06,0.943,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376586,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.27088,1.044703245162964,2.14558,0.5974490310745358,0.4373499999999999,-0.3367154844627321,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.007,-1.45612,0.62909,Uncertain,0.60984,Neutral,,,,10.9,,False,10.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.06,H,-0.3035,0.1284,-22.2302,-4.6419709862034,0.8189711021784798,Pathogenic,0.9988,pathogenic,-4.286,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281P,NP_000537:p.Asp281Pro,"hg19,17:g.7577096_7577097delinsGG",,,,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.94685,1.5212253332138062,10.52653,6.429109873032715,6.236689999999999,4.187979936516357,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.007,1.15024,1.02372,Destabilizing,1.88295,Destabilizing,,,,10.9,,False,10.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.06,H,-0.4738,0.1284,-22.2302,-7.73122410772527,0.8537204289895848,Pathogenic,0.9998,pathogenic,-4.788,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281Q,NP_000537:p.Asp281Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.31574,0.8592342138290405,2.19116,0.7059315365335839,1.25345,0.5108357682667919,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.007,-0.2404,,,0.51972,Neutral,,,,10.9,,False,10.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.06,H,-0.3638,0.1284,-22.2302,-4.6419709862034,0.8708488859765695,Pathogenic,0.9997,pathogenic,-4.635,available,https://doi.org/10.1101/2022.10.22.513328 +D281R,NP_000537:p.Asp281Arg,"hg38,17:g.7673777_7673779delinsCCG",,,,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.16646,1.6340831518173218,3.24354,0.6167817479546214,2.205,0.8916208739773107,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.007,0.37376,-0.61822,Neutral,1.90636,Destabilizing,,,,10.9,,False,10.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.06,H,-0.4386,0.1284,-22.2302,-7.73122410772527,0.863092181505992,Pathogenic,0.9993,pathogenic,-4.829,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281S,NP_000537:p.Asp281Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.52901,0.9660749435424804,2.7449,1.2102474507549443,1.636955,0.8696287253774722,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.007,-0.3307,,,1.36631,Destabilizing,,,,10.9,,False,10.9,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.06,H,-0.3433,0.1284,-22.2302,-7.47190388453418,0.8551576519635428,Pathogenic,0.9994,pathogenic,-4.491,available,https://doi.org/10.1101/2022.10.22.513328 +D281T,NP_000537:p.Asp281Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14786,1.1450575590133667,2.37449,0.7733888592015372,1.2611750000000002,0.4606244296007686,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.007,0.34292,,,1.15013,Destabilizing,,,,10.9,,False,10.9,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.06,H,-0.3733,0.1284,-22.2302,-7.47190388453418,0.8525696596801767,Pathogenic,0.9999,pathogenic,-4.538,available,https://doi.org/10.1101/2022.10.22.513328 +D281V,NP_000537:p.Asp281Val,"hg19,17:g.7577096T>A, hg19,17:g.7673778T>A, hg38,17:g.7673778T>A",,,0.969,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182968,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.31394,0.9129003286361694,1.55816,0.1873919127319656,0.6221099999999999,-0.0632740436340172,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,0.47338,0.94947,Neutral,1.2795,Destabilizing,,,,10.9,,False,10.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.06,H,-0.3839,0.1284,-22.2302,-7.73122410772527,0.8618649176566013,Pathogenic,0.9997,pathogenic,-4.621,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +D281W,NP_000537:p.Asp281Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30315,0.9024428725242616,1.7551,-0.5557653392160361,1.029125,-0.12630766960801806,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.007,-0.21372,,,-0.22009,Neutral,,,,10.9,,False,10.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.06,H,-0.4174,0.1284,-22.2302,-6.86978097273434,0.8708565703140422,Pathogenic,0.9998,pathogenic,-4.884,available,https://doi.org/10.1101/2022.10.22.513328 +D281Y,NP_000537:p.Asp281Tyr,"hg19,17:g.7577097C>A, hg19,17:g.7673779C>A, hg38,17:g.7673779C>A",,,0.957,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376585,Pathogenic/Likely pathogenic,2,Likely oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,-0.176,1.0340683460235596,0.82177,0.1163269959615387,0.322885,-0.029836502019230646,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.007,0.22496,0.16879,Neutral,2.67937,Destabilizing,,,,10.9,,False,10.9,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.06,H,-0.3818,0.1284,-22.2302,-6.86978097273434,0.8689228152043336,Pathogenic,0.9959,pathogenic,-4.659,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282A,NP_000537:p.Arg282Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.17241,0.1734253168106079,1.18673,1.8213369644878137,1.17957,1.496873482243907,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.01,0.12596,,,-0.0353,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.4004,0.1018,-22.2244,-6.48704533042472,0.6368293163401083,Uncertain,0.99,pathogenic,-4.206,available,https://doi.org/10.1101/2022.10.22.513328 +R282C,NP_000537:p.Arg282Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.1098,0.2784649133682251,1.88197,2.40830973456938,1.995885,2.25905486728469,Uncertain,Uncertain,Neutral,Neutral,Uncertain,False,0.01,0.12678,,,-0.03501,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.4093,0.1018,-22.2244,-6.22849488515168,0.7500301044800224,Pathogenic,0.8702,pathogenic,-4.133,available,https://doi.org/10.1101/2022.10.22.513328 +R282D,NP_000537:p.Arg282Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.60149,1.5956634283065796,4.08333,3.956626995511834,3.84241,3.779058497755917,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.01,0.1593,,,-0.15472,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.4915,0.1018,-22.2244,-7.27612260805695,0.8690591042790947,Pathogenic,0.9996,pathogenic,-4.774,available,https://doi.org/10.1101/2022.10.22.513328 +R282E,NP_000537:p.Arg282Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.33598,1.183453917503357,3.39592,3.2844094990977784,2.8659499999999998,2.8101947495488893,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.01,0.11096,,,-0.17583,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.4367,0.1018,-22.2244,-7.27612260805695,0.8038760709228124,Pathogenic,0.9936,pathogenic,-4.564,available,https://doi.org/10.1101/2022.10.22.513328 +R282F,NP_000537:p.Arg282Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.79995,0.3975967764854431,1.8983,1.2973366261280772,2.349125,2.0486433130640385,Uncertain,Uncertain,Neutral,Uncertain,Uncertain,False,0.01,0.09816,,,0.02974,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.21,H,-0.4326,0.1018,-22.2244,-7.0860137439162,0.7703174665281602,Pathogenic,0.9957,pathogenic,-4.581,available,https://doi.org/10.1101/2022.10.22.513328 +R282G,NP_000537:p.Arg282Gly,"hg19,17:g.7577094G>C, hg19,17:g.7673776G>C, hg38,17:g.7673776G>C",,,0.863,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",140821,Pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.65994,1.3868036270141602,3.34966,3.8196858827719615,3.0048000000000004,3.239812941385981,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.01,0.09592,-0.04226,Neutral,-0.02285,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.368,0.1018,-8.9365,-7.68498215740767,0.8568261532349332,Pathogenic,0.9871,pathogenic,-4.498,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282H,NP_000537:p.Arg282His,"hg19,17:g.7577092_7577093delinsGT, hg38,17:g.7673774_7673775delinsAT",,,,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,5.41894,0.8326539993286133,1.7568,2.149594258958348,3.58787,3.784267129479174,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.01,0.07286,-0.00962,Neutral,-0.0227,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.3024,0.1018,-8.9365,-7.0860137439162,0.7881515797366464,Pathogenic,0.9375,pathogenic,-4.178,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282I,NP_000537:p.Arg282Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.88067,0.3380311727523803,1.72823,0.921147177318582,2.30445,1.900908588659291,Uncertain,Uncertain,Neutral,Uncertain,Neutral,False,0.01,0.09582,,,-0.03388,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.4298,0.1018,-22.2244,-5.26666468456558,0.5751960354857709,Uncertain,0.9842,pathogenic,-4.192,available,https://doi.org/10.1101/2022.10.22.513328 +R282K,NP_000537:p.Arg282Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.85351,0.1993996500968933,2.13844,2.2988797923374182,1.495975,1.5761948961687091,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.01,0.05434,,,-0.01505,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,97.21,H,-0.2907,0.1018,-22.2244,-3.53886314041208,0.3776536064837923,Uncertain,0.8745,pathogenic,-3.643,available,https://doi.org/10.1101/2022.10.22.513328 +R282L,NP_000537:p.Arg282Leu,"hg19,17:g.7577093C>A, hg38,17:g.7673775C>A",,,0.898,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",182938,Uncertain significance,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22872,-0.7600172758102417,0.02755,0.5404129226663215,0.128135,0.38456646133316075,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.01,0.1105,-0.01573,Neutral,-0.04294,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.33,0.1018,-7.9366,-3.79121713083018,0.0077016032094239,Benign,0.9405,pathogenic,-3.89,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282M,NP_000537:p.Arg282Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.77311,-0.1313469409942627,0.68707,1.0947992006015186,0.7300899999999999,0.9339546003007593,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.01,0.1274,,,-0.02406,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.3687,0.1018,-22.2244,-5.72845352701328,0.4400039030338756,Uncertain,0.9882,pathogenic,-4.172,available,https://doi.org/10.1101/2022.10.22.513328 +R282N,NP_000537:p.Arg282Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.64199,1.3554013967514038,2.55034,2.5304033983470777,2.596165,2.586196699173539,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.01,0.12292,,,-0.04324,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.4153,0.1018,-22.2244,-7.27612260805695,0.8698712570451417,Pathogenic,0.9986,pathogenic,-4.554,available,https://doi.org/10.1101/2022.10.22.513328 +R282P,NP_000537:p.Arg282Pro,"hg19,17:g.7577092_7577093delinsGG, hg19,17:g.7577093C>G, hg19,17:g.7673775C>G, hg38,17:g.7673775C>G",,,0.911,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376659,Pathogenic/Likely pathogenic,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,9.11021,1.4226014614105225,12.76803,7.989824426215401,10.939119999999999,8.5500172131077,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.01,0.1232,0.46826,Neutral,-0.03699,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.5425,0.1018,-22.2244,-7.68498215740767,0.870327727664185,Pathogenic,0.9994,pathogenic,-4.512,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282Q,NP_000537:p.Arg282Gln,"hg19,17:g.7577093C>T, hg19,17:g.7673775C>T, hg38,17:g.7673775C>T",,3.9770286823e-06,0.887,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",237956,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.38433,0.5664276480674744,1.08197,1.9734995332093512,1.73315,2.1789147666046755,Uncertain,Uncertain,Neutral,Neutral,Uncertain,False,0.01,0.12454,0.05694,Neutral,-0.0272,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.3751,0.1018,-22.2244,-6.94230616144628,0.5297725140910928,Uncertain,0.8664,pathogenic,-4.199,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282S,NP_000537:p.Arg282Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.53906,1.082878828048706,2.68401,2.883991231288471,2.611535,2.7115256156442356,Uncertain,Uncertain,Uncertain,Uncertain,Uncertain,False,0.01,0.129,,,-0.03655,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.401,0.1018,-22.2244,-5.83254920892626,0.4661274651224045,Uncertain,0.9962,pathogenic,-4.071,available,https://doi.org/10.1101/2022.10.22.513328 +R282T,NP_000537:p.Arg282Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.53539,1.5621473789215088,1.27245,2.1540126292596216,1.40392,1.8447013146298108,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.01,0.08384,,,-0.03535,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.4053,0.1018,-22.2244,-6.48704533042472,0.8610729496384137,Pathogenic,0.9978,pathogenic,-4.517,available,https://doi.org/10.1101/2022.10.22.513328 +R282V,NP_000537:p.Arg282Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.60303,0.6920953392982483,1.11259,1.2212040313001031,1.85781,1.9121170156500515,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.01,0.10804,,,-0.06309,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,97.21,H,-0.4169,0.1018,-22.2244,-6.32155105518406,0.8357707782166817,Pathogenic,0.9904,pathogenic,-4.496,available,https://doi.org/10.1101/2022.10.22.513328 +R282W,NP_000537:p.Arg282Trp,"hg19,17:g.7577094G>A, hg19,17:g.7577094_7577095delinsAA, hg19,17:g.7673776G>A, hg19,17:g.7673776_7673777delinsAA, hg38,17:g.7673776G>A, hg38,17:g.7673776_7673777delinsAA",,3.9775665248e-06,0.896,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12364,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,6.32707,0.5399423837661743,2.43027,1.3832141020152091,4.37867,3.8551420510076047,Uncertain,Uncertain,Neutral,Destabilizing,Destabilizing,False,0.01,0.11894,-0.08825,Neutral,-0.02922,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.21,H,-0.3503,0.1018,-8.9365,-6.64398279790623,0.7567491892719951,Pathogenic,0.9462,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R282Y,NP_000537:p.Arg282Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.37436,0.6491360068321228,2.01088,1.9824142552753872,1.6926199999999998,1.6783871276376936,Uncertain,Neutral,Neutral,Neutral,Neutral,False,0.01,0.105,,,0.03749,Neutral,,,,14.7,,True,14.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,97.21,H,-0.4219,0.1018,-22.2244,-7.0860137439162,0.8034458082034881,Pathogenic,0.987,pathogenic,-4.428,available,https://doi.org/10.1101/2022.10.22.513328 +R283A,NP_000537:p.Arg283Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.53897,0.4040588736534118,0.4585,0.6557620395146496,0.498735,0.5973660197573247,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.09484,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.3273,0.8968,-22.2273,-4.88528236491981,0.0261327887297848,Benign,0.9516,pathogenic,-3.588,available,https://doi.org/10.1101/2022.10.22.513328 +R283C,NP_000537:p.Arg283Cys,"hg19,17:g.7577091G>A, hg38,17:g.7673773G>A",9.55779278705e-05,7.15876551066e-05,0.740,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",127824,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.18039,0.4600486159324646,1.44898,1.4141992565274693,1.3146849999999999,1.2972946282637348,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.10442,-0.13649,Neutral,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.2603,0.8968,-7.3546,-3.11296296623348,0.0296076070566691,Benign,0.6812,pathogenic,-3.7,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R283D,NP_000537:p.Arg283Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.19389,0.8167406320571899,1.73435,1.5090943234236436,1.4641199999999999,1.3514921617118216,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.1617,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.4183,0.8968,-22.2273,-5.24198780713334,0.0314398197972887,Benign,0.9866,pathogenic,-3.779,available,https://doi.org/10.1101/2022.10.22.513328 +R283E,NP_000537:p.Arg283Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.12735,0.5828985571861267,0.76735,0.7897829542801654,0.44734999999999997,0.4585664771400827,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.11272,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.2958,0.8968,-8.9394,-4.31891601029769,0.0194053819087281,Benign,0.9497,pathogenic,-3.496,available,https://doi.org/10.1101/2022.10.22.513328 +R283F,NP_000537:p.Arg283Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.71769,0.6861733198165894,0.6619,0.3019510844916895,0.689795,0.5098205422458448,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.14582,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.97,H,-0.3594,0.8968,-22.2273,-6.66771559775865,0.7134418883910211,Pathogenic,0.9745,pathogenic,-4.174,available,https://doi.org/10.1101/2022.10.22.513328 +R283G,NP_000537:p.Arg283Gly,"hg19,17:g.7577091G>C, hg38,17:g.7673773G>C",,,0.714,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",580186,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.38823,1.2067290544509888,1.57721,1.8153123160952056,1.48272,1.6017711580476028,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.014,0.09518,-0.00455,Neutral,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.2948,0.8968,-8.9394,-6.02007111657914,0.5683618246267566,Uncertain,0.887,pathogenic,-3.938,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R283H,NP_000537:p.Arg283His,"hg19,17:g.7577090C>T, hg19,17:g.7673772C>T, hg38,17:g.7673772C>T",,3.9769021523e-05,0.836,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",142324,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.2335,0.7231679558753967,0.46361,0.5053194769788277,0.8485550000000001,0.8694097384894139,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.09272,0.0487,Neutral,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.2292,0.8968,-8.9394,-5.39678325222424,0.0406853243385057,Benign,0.549,ambiguous,-3.647,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R283I,NP_000537:p.Arg283Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.3722,0.2373428344726562,0.08503,0.0010241493788942,0.22861499999999998,0.1866120746894471,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.07878,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.3567,0.8968,-22.2273,-6.03952946471489,0.5108935196120943,Uncertain,0.9034,pathogenic,-3.888,available,https://doi.org/10.1101/2022.10.22.513328 +R283K,NP_000537:p.Arg283Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.0033,0.2100799083709716,0.26361,0.4656128667032544,0.13345500000000002,0.23445643335162722,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.04444,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.97,H,-0.1061,0.8968,-0.3888,-1.81457329615729,1.575294263318473e-07,Benign,0.2513,benign,-2.835,available,https://doi.org/10.1101/2022.10.22.513328 +R283L,NP_000537:p.Arg283Leu,"hg19,17:g.7577090C>A, hg38,17:g.7673772C>A",,,0.685,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.24033,0.2263439893722534,0.09694,-0.2429415201429741,0.16863499999999998,-0.0013057600714870554,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.06018,0.08154,Neutral,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.3297,0.8968,-22.2273,-6.35027583660817,0.2315886254697959,Benign,0.8316,pathogenic,-3.685,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R283M,NP_000537:p.Arg283Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22111,0.2853214740753174,0.68503,0.2519177273640594,0.45307000000000003,0.2365138636820297,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.03894,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.2956,0.8968,-22.2273,-6.16826820355761,0.3185885570270371,Benign,0.9261,pathogenic,-3.765,available,https://doi.org/10.1101/2022.10.22.513328 +R283N,NP_000537:p.Arg283Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.27992,0.7163392305374146,1.11224,0.9561520755969574,0.6960799999999999,0.6180360377984787,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.09928,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.3422,0.8968,-22.2273,-4.9441430299059,0.0615201953029989,Benign,0.9767,pathogenic,-3.588,available,https://doi.org/10.1101/2022.10.22.513328 +R283P,NP_000537:p.Arg283Pro,"hg19,17:g.7577089_7577090delinsAG, hg19,17:g.7577090C>G, hg19,17:g.7673772C>G, hg38,17:g.7673772C>G",,,0.804,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",486555,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.69342,2.3823225498199463,7.27585,7.355939145418244,4.984635,5.024679572709122,Uncertain,Uncertain,Destabilizing,Destabilizing,Destabilizing,False,0.014,0.09194,-0.12592,Neutral,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.4694,0.8968,-22.2273,-7.14798341622502,0.7162607382875055,Pathogenic,0.9928,pathogenic,-4.052,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R283Q,NP_000537:p.Arg283Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.30177,0.3836557269096374,0.31429,0.7032734614628863,0.30803,0.5025217307314431,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.0971,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.302,0.8968,-22.2273,-5.06566589485979,0.0056528529605504,Benign,0.4967,ambiguous,-3.411,available,https://doi.org/10.1101/2022.10.22.513328 +R283S,NP_000537:p.Arg283Ser,"hg38,17:g.7673773G>T",,3.9770919504e-06,0.687,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.65375,0.6587062478065491,1.13367,1.1678524135828163,0.89371,0.9108012067914082,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.11702,0.01373,Neutral,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.26,0.8968,-8.9394,-4.65990199428634,0.0353403553194113,Benign,0.9763,pathogenic,-3.494,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +R283T,NP_000537:p.Arg283Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.65301,0.6170058250427246,0.74932,0.7870433828563328,0.701165,0.7200266914281663,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.06148,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.3322,0.8968,-22.2273,-4.90434831297447,0.0260475640366957,Benign,0.9458,pathogenic,-3.532,available,https://doi.org/10.1101/2022.10.22.513328 +R283V,NP_000537:p.Arg283Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.8561,0.4927003979682922,0.14932,0.2400296326555334,0.50271,0.5480648163277667,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.09248,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,DOWN,neutral,neutral,False,neutral,neutral,95.97,H,-0.3438,0.8968,-22.2273,-5.99490833784294,0.6056714299685131,Uncertain,0.9178,pathogenic,-3.87,available,https://doi.org/10.1101/2022.10.22.513328 +R283W,NP_000537:p.Arg283Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.01852,0.6001590490341187,0.7068,-0.2371394168649027,0.86266,0.3906902915675487,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.17688,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.97,H,-0.345,0.8968,-22.2273,-6.66771559775865,0.7670761073656769,Pathogenic,0.8078,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328 +R283Y,NP_000537:p.Arg283Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.57587,0.6701578497886658,0.52415,0.3892834260870464,0.55001,0.48257671304352323,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.014,0.09454,,Uncertain,,Uncertain,,,Uncertain,48.6,,True,48.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.97,H,-0.3488,0.8968,-22.2273,-6.66771559775865,0.4249704105291157,Uncertain,0.928,pathogenic,-4.177,available,https://doi.org/10.1101/2022.10.22.513328 +T284A,NP_000537:p.Thr284Ala,"hg19,17:g.7577088T>C, hg38,17:g.7673770T>C",,,0.460,"COSMIC,ClinVar,saturation_mutlist",964952,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.7248,-0.1739710569381714,-0.0619,-0.0139999859251255,-0.39335,-0.36939999296256276,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,-0.08022,0.10033,Neutral,-0.10888,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,DOWN,neutral,neutral,False,neutral,neutral,95.98,H,-0.0889,1.353,-0.8052,-2.3339254732691,0.0050191128834465,Benign,0.2587,benign,-3.194,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T284C,NP_000537:p.Thr284Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.01207,-0.2087098956108093,0.60238,0.7439674925460243,0.307225,0.3780187462730122,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,-0.114,,Uncertain,-0.18408,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,DOWN,neutral,neutral,False,neutral,neutral,95.98,H,-0.2341,1.353,-22.2273,-3.94862837231201,0.7714462462401184,Pathogenic,0.7718,pathogenic,-3.927,available,https://doi.org/10.1101/2022.10.22.513328 +T284D,NP_000537:p.Thr284Asp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.08074,0.1803280711174011,0.59864,0.4681808384482144,0.25894999999999996,0.1937204192241072,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,0.3028,,Uncertain,-0.33559,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,95.98,H,-0.3138,1.353,-22.2273,-4.34777641349292,0.6947168334646521,Pathogenic,0.9354,pathogenic,-3.933,available,https://doi.org/10.1101/2022.10.22.513328 +T284E,NP_000537:p.Thr284Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.10046,-0.1414777040481567,0.22585,0.0346075899040104,-0.437305,-0.5329262050479948,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,1.04796,,Uncertain,-0.53407,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,95.98,H,-0.2891,1.353,-22.2273,-5.05003937782916,0.6410322569464222,Uncertain,0.9007,pathogenic,-3.813,available,https://doi.org/10.1101/2022.10.22.513328 +T284F,NP_000537:p.Thr284Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.57099,0.0391547679901123,-0.07245,-0.2057759861015928,-0.82172,-0.8883829930507965,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,0.63822,,Uncertain,-0.08057,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,95.98,H,-0.3055,1.353,-22.2273,-5.69551557163214,0.8339479394608507,Pathogenic,0.651,pathogenic,-3.992,available,https://doi.org/10.1101/2022.10.22.513328 +T284G,NP_000537:p.Thr284Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.09146,0.5177847146987915,0.91939,0.862991552263709,0.505425,0.4772257761318545,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,-0.09942,,Uncertain,-0.09496,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,DOWN,neutral,neutral,False,neutral,neutral,95.98,H,-0.2717,1.353,-22.2273,-4.75295064651016,0.3468646784972768,Uncertain,0.5084,ambiguous,-3.617,available,https://doi.org/10.1101/2022.10.22.513328 +T284H,NP_000537:p.Thr284His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.54723,0.0530352592468261,-0.12007,-0.1485604634597931,-0.33365,-0.34789523172989656,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,0.63566,,Uncertain,-0.35154,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,95.98,H,-0.2129,1.353,-7.9395,-3.62825289065798,0.0096209380811172,Benign,0.59,pathogenic,-3.477,available,https://doi.org/10.1101/2022.10.22.513328 +T284I,NP_000537:p.Thr284Ile,"hg19,17:g.7577087G>A, hg38,17:g.7673769G>A",,,0.699,"COSMIC,ClinVar,saturation_mutlist",216471,Likely benign,3,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.15177,-0.2758586406707763,-0.62347,-0.5448124331000348,-0.88762,-0.8482912165500174,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,-0.25024,-0.15426,Neutral,-0.2425,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,95.98,H,-0.1461,1.353,-6.9395,-2.06270142512814,0.0061875841736767,Benign,0.5825,pathogenic,-3.343,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T284K,NP_000537:p.Thr284Lys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.96938,-0.2517731189727783,0.17891,-0.2054536505844589,-0.395235,-0.5874168252922295,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,0.12318,-0.17749,Neutral,-0.29259,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,95.98,H,-0.2813,1.353,-22.2273,-4.6111442380541,0.0663706688218792,Benign,0.7995,pathogenic,-3.598,available,https://doi.org/10.1101/2022.10.22.513328 +T284L,NP_000537:p.Thr284Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.29667,-0.2940595149993896,-0.45952,-0.6729428424357281,-0.878095,-0.984806421217864,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,-0.31676,,Uncertain,-0.37285,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,95.98,H,-0.2083,1.353,-8.9394,-3.98154757536651,0.0846914174269106,Benign,0.2982,benign,-3.536,available,https://doi.org/10.1101/2022.10.22.513328 +T284M,NP_000537:p.Thr284Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.35917,-0.2508306503295898,-0.09252,-0.2360342837115253,-0.725845,-0.7976021418557626,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,-0.13164,,Uncertain,-0.75065,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,95.98,H,-0.1752,1.353,-8.9394,-3.37821417242058,0.0089710863335161,Benign,0.1492,benign,-3.456,available,https://doi.org/10.1101/2022.10.22.513328 +T284N,NP_000537:p.Thr284Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.69233,0.0715411305427551,0.2881,0.16643169967685,-0.202115,-0.262949150161575,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,-0.3815,,Uncertain,-0.18564,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,95.98,H,-0.186,1.353,-8.9394,-3.24294529249877,0.0004106875649671,Benign,0.3113,benign,-3.383,available,https://doi.org/10.1101/2022.10.22.513328 +T284P,NP_000537:p.Thr284Pro,"hg19,17:g.7577088T>G, hg19,17:g.7673770T>G, hg38,17:g.7673770T>G",,,0.569,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1763670,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.99313,1.5308616161346436,6.61327,7.224169450491368,4.3032,4.608649725245684,Uncertain,Uncertain,Uncertain,Destabilizing,Destabilizing,False,0.028,0.22444,-0.2744,Neutral,-0.19542,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,-,uncertain,neutral,False,neutral,neutral,95.98,H,-0.3625,1.353,-22.2273,-6.55732546763091,0.730739205711032,Pathogenic,0.912,pathogenic,-3.947,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T284Q,NP_000537:p.Thr284Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.71862,-0.1836354732513427,0.18265,0.0814090015499657,-0.26798500000000003,-0.3186054992250172,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,0.37514,,Uncertain,-0.23864,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,95.98,H,-0.1955,1.353,-8.9394,-4.14074186450783,0.0401957249822921,Benign,0.5815,pathogenic,-3.386,available,https://doi.org/10.1101/2022.10.22.513328 +T284R,NP_000537:p.Thr284Arg,"hg19,17:g.7577087G>C, hg38,17:g.7673769G>C",,,0.728,"ClinVar,saturation_mutlist",2679230,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.74954,-0.3201079368591308,0.17755,-0.4807373606538645,-0.285995,-0.6151386803269323,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,0.4352,,Uncertain,-0.44493,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,95.98,H,-0.2842,1.353,-22.2273,-2.54695884997668,0.2381645959285238,Benign,0.7429,pathogenic,-3.614,available,https://doi.org/10.1101/2022.10.22.513328 +T284S,NP_000537:p.Thr284Ser,"hg19,17:g.7577088T>A, hg38,17:g.7673770T>A",,,0.495,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",458571,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.73201,0.0505791306495666,0.37245,0.4456733873710561,-0.17978000000000002,-0.14316830631447197,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,0.17018,-0.06817,Neutral,-0.1176,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,neutral,neutral,potentially_damaging,DOWN,neutral,neutral,False,neutral,neutral,95.98,H,-0.0725,1.353,-4.6916,-1.78489914809022,1.6826522415187323e-05,Benign,0.2344,benign,-3.016,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +T284V,NP_000537:p.Thr284Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.49032,-0.0776156783103942,-0.39524,-0.3349252084691739,-0.44277999999999995,-0.41262260423458696,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,-0.27324,,Uncertain,-0.04749,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,95.98,H,-0.2117,1.353,-22.2273,-5.40818695111101,0.4978131721281743,Uncertain,0.4877,ambiguous,-3.625,available,https://doi.org/10.1101/2022.10.22.513328 +T284W,NP_000537:p.Thr284Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.94118,-0.0268380641937255,-0.18878,-0.6375494565372353,-0.56498,-0.7893647282686176,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,-0.07976,,Uncertain,-0.1606,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,damaging,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,95.98,H,-0.2984,1.353,-22.2273,-5.69551557163214,0.7889859019637193,Pathogenic,0.8708,pathogenic,-4.124,available,https://doi.org/10.1101/2022.10.22.513328 +T284Y,NP_000537:p.Thr284Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-1.36799,-0.0109226703643798,-0.19932,-0.1419418094356106,-0.783655,-0.7549659047178053,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.028,-0.1042,,Uncertain,-0.37388,Neutral,,,Uncertain,70.9,P,True,70.9,0.171,uncertain,neutral,potentially_damaging,UP,neutral,neutral,False,neutral,neutral,95.98,H,-0.2391,1.353,-8.9394,-5.37991928172987,0.5733601461266271,Uncertain,0.7255,pathogenic,-3.808,available,https://doi.org/10.1101/2022.10.22.513328 +E285A,NP_000537:p.Glu285Ala,"hg38,17:g.7673766T>G",,,0.910,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.00754,0.7782527208328247,0.29898,1.4055654588892847,0.14572000000000002,0.6990127294446423,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.06538,0.06373,Neutral,0.8563,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.28,H,-0.227,1.0175,-22.2273,-6.95320772521685,0.6780560271371514,Uncertain,0.928,pathogenic,-3.902,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E285C,NP_000537:p.Glu285Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.57947,0.9089773893356324,0.6102,2.047799638752399,0.594835,1.3136348193761995,Neutral,Uncertain,Neutral,Neutral,Neutral,False,0.027,0.00336,,Uncertain,0.81596,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.28,H,-0.2963,1.0175,-22.2273,-7.02119446636457,0.8513810202459848,Pathogenic,0.996,pathogenic,-4.425,available,https://doi.org/10.1101/2022.10.22.513328 +E285D,NP_000537:p.Glu285Asp,"hg19,17:g.7577083C>A, hg19,17:g.7673765C>A",,,0.524,"cBioPortal,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.78107,0.8254698514938354,0.08571,1.576487936119933,0.43339,1.1787789680599665,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.03754,0.03583,Neutral,0.69619,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.28,H,-0.0832,1.0175,-0.7797,-2.56733882937687,4.0873312263812165e-05,Benign,0.902,pathogenic,-3.008,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E285F,NP_000537:p.Glu285Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.28392,1.482696294784546,-0.04014,0.2034419645986168,-0.16203,-0.040239017700691604,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.027,-0.0453,,Uncertain,0.8488,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.28,H,-0.274,1.0175,-22.2273,-7.26482183738778,0.8686135247093967,Pathogenic,0.9988,pathogenic,-4.415,available,https://doi.org/10.1101/2022.10.22.513328 +E285G,NP_000537:p.Glu285Gly,"hg19,17:g.7577084T>C, hg38,17:g.7673766T>C",,,0.923,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",919894,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.1343,1.8136417865753167,1.67721,2.7921340020620056,1.405755,1.9632170010310028,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.027,0.02052,0.01964,Neutral,0.83455,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.28,H,-0.2527,1.0175,-22.2273,-7.26482183738778,0.7124256363387507,Pathogenic,0.9509,pathogenic,-4.003,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E285H,NP_000537:p.Glu285His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14658,1.310420036315918,0.07041,0.8795199169177156,0.108495,0.5130499584588578,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.027,0.00848,,Uncertain,0.22346,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.28,H,-0.2652,1.0175,-22.2273,-7.26482183738778,0.8707481208299305,Pathogenic,0.9962,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328 +E285I,NP_000537:p.Glu285Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.01859,1.333576202392578,0.63333,0.6733419882113664,0.30737,0.3273759941056832,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.027,0.15744,,Uncertain,0.85977,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.28,H,-0.2793,1.0175,-22.2273,-7.26482183738778,0.86715094464321,Pathogenic,0.9962,pathogenic,-4.402,available,https://doi.org/10.1101/2022.10.22.513328 +E285K,NP_000537:p.Glu285Lys,"hg19,17:g.7577083_7577085delinsTTT, hg19,17:g.7577085C>T, hg19,17:g.7673767C>T, hg38,17:g.7673765_7673767delinsTTT, hg38,17:g.7673767C>T",,,0.910,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",420133,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,-0.29321,1.9246888160705569,1.95238,1.833786363777341,0.829585,0.7702881818886705,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.027,0.0758,-0.15476,Neutral,0.81643,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.28,H,-0.249,1.0175,-22.2273,-6.7541549855419,0.5802928899042646,Uncertain,0.9737,pathogenic,-4.14,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E285L,NP_000537:p.Glu285Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.79162,1.115875482559204,0.37789,0.4431106313077304,-0.206865,-0.1742546843461348,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.027,0.06664,,Uncertain,0.85827,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.28,H,-0.2814,1.0175,-22.2273,-7.26482183738778,0.8195532070499358,Pathogenic,0.992,pathogenic,-3.984,available,https://doi.org/10.1101/2022.10.22.513328 +E285M,NP_000537:p.Glu285Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.811,0.926342785358429,0.55952,0.8214830069261259,-0.12574000000000002,0.005241503463062902,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.00314,,Uncertain,0.83798,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.28,H,-0.2303,1.0175,-22.2273,-7.26482183738778,0.8165121365136547,Pathogenic,0.9895,pathogenic,-4.153,available,https://doi.org/10.1101/2022.10.22.513328 +E285N,NP_000537:p.Glu285Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.17243,1.6783673763275146,0.88129,1.5272211360225445,0.52686,0.8498255680112723,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.027,-0.16422,,Uncertain,0.79802,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.28,H,-0.2532,1.0175,-22.2273,-3.69263011870532,0.7297544921489117,Pathogenic,0.9926,pathogenic,-3.979,available,https://doi.org/10.1101/2022.10.22.513328 +E285P,NP_000537:p.Glu285Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.17298,2.1733102798461914,9.59796,6.077648252468384,6.38547,4.625314126234192,Destabilizing,Destabilizing,Destabilizing,Destabilizing,Destabilizing,False,0.027,0.35196,,Uncertain,0.82973,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.28,H,-0.3839,1.0175,-22.2273,-7.26482183738778,0.859088413966755,Pathogenic,0.9991,pathogenic,-4.382,available,https://doi.org/10.1101/2022.10.22.513328 +E285Q,NP_000537:p.Glu285Gln,"hg19,17:g.7577085C>G, hg19,17:g.7673767C>G, hg38,17:g.7673767C>G",,,0.883,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",954095,Uncertain significance,2,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.38545,0.9332114458084106,0.29048,1.1908383939026197,-0.047485,0.4026941969513098,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.0099,0.06215,Neutral,0.85191,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.28,H,-0.1995,1.0175,-22.2273,-3.46091995644647,0.5247362620534087,Uncertain,0.9185,pathogenic,-3.732,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E285R,NP_000537:p.Glu285Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.0598,1.9268821477890008,2.02959,1.4287014349395857,0.9848949999999999,0.6844507174697928,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.027,0.07294,,Uncertain,0.83417,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.28,H,-0.2417,1.0175,-8.9394,-6.87868159016671,0.7510348299920128,Pathogenic,0.9783,pathogenic,-4.081,available,https://doi.org/10.1101/2022.10.22.513328 +E285S,NP_000537:p.Glu285Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.78866,1.4228429794311523,1.09184,2.2428844442836264,0.94025,1.5157722221418133,Neutral,Uncertain,Uncertain,Neutral,Neutral,False,0.027,0.00444,,Uncertain,0.80765,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.28,H,-0.2404,1.0175,-22.2273,-7.02119446636457,0.837841042464772,Pathogenic,0.975,pathogenic,-3.974,available,https://doi.org/10.1101/2022.10.22.513328 +E285T,NP_000537:p.Glu285Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.59678,1.6647313833236694,0.84422,1.5932126651864502,0.7204999999999999,1.094996332593225,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.027,0.11324,,Uncertain,0.76561,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,96.28,H,-0.2563,1.0175,-22.2273,-7.02119446636457,0.8699140235098215,Pathogenic,0.9862,pathogenic,-4.274,available,https://doi.org/10.1101/2022.10.22.513328 +E285V,NP_000537:p.Glu285Val,"hg19,17:g.7577084T>A, hg19,17:g.7673766T>A, hg38,17:g.7673766T>A",,0.0,0.936,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",12384,Pathogenic,1,Oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.19113,1.4066020250320437,0.32483,0.7806465494130507,0.25798,0.48588827470652535,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.027,0.10814,0.00098,Neutral,0.78293,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,96.28,H,-0.2402,1.0175,-22.2273,-7.26482183738778,0.8599815909545623,Pathogenic,0.9811,pathogenic,-4.218,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E285W,NP_000537:p.Glu285Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.03877,1.2089701890945437,0.62381,0.0768285629883364,0.33129,0.0577992814941682,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.027,-0.28266,,Uncertain,0.85871,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.28,H,-0.2162,1.0175,-8.9394,-7.26482183738778,0.8696864149181326,Pathogenic,0.9991,pathogenic,-4.444,available,https://doi.org/10.1101/2022.10.22.513328 +E285Y,NP_000537:p.Glu285Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.18658,1.1425106525421145,0.02075,0.4647413444292786,-0.082915,0.13908067221463932,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.027,-0.12708,,Uncertain,0.88712,Neutral,,,Uncertain,29.1,,True,29.1,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,96.28,H,-0.2748,1.0175,-22.2273,-7.26482183738778,0.8454117832036288,Pathogenic,0.9976,pathogenic,-4.216,available,https://doi.org/10.1101/2022.10.22.513328 +E286A,NP_000537:p.Glu286Ala,"hg19,17:g.7577081T>G, hg19,17:g.7673763T>G, hg38,17:g.7673763T>G",,,0.913,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376593,Likely pathogenic,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.01326,1.1360845565795898,1.72653,0.5966485385775074,1.8698949999999999,1.3049542692887537,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.023,0.0227,-0.10724,Neutral,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.87,H,-0.3167,0.0424,-22.2273,-7.90930635631685,0.8126932455667674,Pathogenic,0.8823,pathogenic,-3.941,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E286C,NP_000537:p.Glu286Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.19666,0.728181779384613,1.67721,1.1068135345271664,1.936935,1.6517367672635832,Uncertain,Uncertain,Neutral,Neutral,Neutral,False,0.023,0.0227,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.87,H,-0.3861,0.0424,-22.2273,-7.90930635631685,0.8698395592205053,Pathogenic,0.9947,pathogenic,-4.422,available,https://doi.org/10.1101/2022.10.22.513328 +E286D,NP_000537:p.Glu286Asp,"hg19,17:g.7577080T>G, hg38,17:g.7673762T>A, hg38,17:g.7673762T>G",,,0.765,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",3893866,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.69984,0.057387351989746,0.90272,0.7659126323703854,1.30128,1.2328763161851928,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,0.01264,-0.05036,Neutral,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.87,H,-0.2146,0.0424,-8.9394,-3.90618216975713,0.1905307891879662,Benign,0.9266,pathogenic,-3.579,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E286F,NP_000537:p.Glu286Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.95778,1.303291082382202,1.87143,-0.0209929381296775,1.914605,0.9683935309351613,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,0.02814,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.87,H,-0.3637,0.0424,-22.2273,-7.90930635631685,0.8234987158424463,Pathogenic,0.9985,pathogenic,-4.508,available,https://doi.org/10.1101/2022.10.22.513328 +E286G,NP_000537:p.Glu286Gly,"hg19,17:g.7577081T>C, hg19,17:g.7673763T>C, hg38,17:g.7673763T>C",,,0.913,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376590,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.00501,1.887989163398743,3.40136,1.5262247676826768,3.203185,2.2656173838413385,Destabilizing,Uncertain,Uncertain,Destabilizing,Uncertain,False,0.023,0.0227,-0.06361,Neutral,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.87,H,-0.3424,0.0424,-22.2273,-7.90930635631685,0.8140714270677522,Pathogenic,0.8932,pathogenic,-4.062,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E286H,NP_000537:p.Glu286His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.46296,1.3758430480957031,2.19694,0.1969544391649197,2.32995,1.3299572195824598,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.023,0.02354,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.87,H,-0.355,0.0424,-22.2273,-7.90930635631685,0.870458070176432,Pathogenic,0.9955,pathogenic,-4.235,available,https://doi.org/10.1101/2022.10.22.513328 +E286I,NP_000537:p.Glu286Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.1246,0.8040850162506104,0.85714,-0.5067089056708568,0.99087,0.3089455471645716,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,0.00678,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.87,H,-0.369,0.0424,-22.2273,-6.4916484275469,0.6201150502836061,Uncertain,0.9713,pathogenic,-4.136,available,https://doi.org/10.1101/2022.10.22.513328 +E286K,NP_000537:p.Glu286Lys,"hg19,17:g.7577082C>T, hg19,17:g.7577082_7577083delinsTT, hg19,17:g.7673764C>T, hg19,17:g.7673764_7673765delinsTT, hg38,17:g.7673764C>T, hg38,17:g.7673764_7673765delinsTT",,,0.949,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",183752,Pathogenic/Likely pathogenic,2,Oncogenic,1,Tier I - Strong,1,P53 DNA-binding domain (PF00870),2.60.40.720,1.51713,1.7601134777069092,2.32041,0.6112397502160388,1.9187699999999999,1.0641848751080194,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.023,0.02972,0.02869,Neutral,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.87,H,-0.2709,0.0424,-8.9394,-6.24017220790887,0.7011857895247449,Pathogenic,0.9477,pathogenic,-3.982,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E286L,NP_000537:p.Glu286Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.6111,0.7345227003097534,0.72755,-0.564851902406156,0.669325,0.02312404879692198,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,0.0227,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.87,H,-0.3712,0.0424,-22.2273,-7.16464546047637,0.8706711220409482,Pathogenic,0.9735,pathogenic,-4.168,available,https://doi.org/10.1101/2022.10.22.513328 +E286M,NP_000537:p.Glu286Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.91242,0.9830356240272522,1.13163,-0.0613197581307228,1.022025,0.4255501209346386,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,0.0228,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.87,H,-0.32,0.0424,-22.2273,-7.16464546047637,0.8705651021235515,Pathogenic,0.9622,pathogenic,-4.282,available,https://doi.org/10.1101/2022.10.22.513328 +E286N,NP_000537:p.Glu286Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.43022,1.063927173614502,1.65272,0.7977535827749979,1.04147,0.6139867913874989,Neutral,Neutral,Uncertain,Neutral,Neutral,False,0.023,0.0227,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.87,H,-0.3429,0.0424,-22.2273,-4.15346829351254,0.6955914676434517,Pathogenic,0.9783,pathogenic,-4.034,available,https://doi.org/10.1101/2022.10.22.513328 +E286P,NP_000537:p.Glu286Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,4.76805,1.8073046207427976,-13.62517,6.259678185743178,-4.428560000000001,5.513864092871589,Uncertain,Destabilizing,Uncertain,Stabilizing,Destabilizing,False,0.023,0.0238,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.87,H,-0.4737,0.0424,-22.2273,-7.90930635631685,0.8597076942664754,Pathogenic,0.9987,pathogenic,-4.502,available,https://doi.org/10.1101/2022.10.22.513328 +E286Q,NP_000537:p.Glu286Gln,"hg19,17:g.7577082C>G, hg19,17:g.7673764C>G, hg38,17:g.7673764C>G",,,0.905,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376591,Conflicting classifications of pathogenicity,1,Likely oncogenic,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.53966,0.9178682565689088,1.47279,0.4139920901139393,1.0062250000000001,0.4768260450569697,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,0.02276,-0.03722,Neutral,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.87,H,-0.2892,0.0424,-22.2273,-4.74818094996343,0.8247652464799524,Pathogenic,0.8972,pathogenic,-3.936,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E286R,NP_000537:p.Glu286Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.90433,1.8736010789871216,2.50884,0.3681015024109274,2.206585,1.1362157512054638,Uncertain,Neutral,Uncertain,Uncertain,Neutral,False,0.023,-0.00372,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.87,H,-0.3992,0.0424,-22.2273,-7.64405279326017,0.8682067716917614,Pathogenic,0.971,pathogenic,-4.309,available,https://doi.org/10.1101/2022.10.22.513328 +E286S,NP_000537:p.Glu286Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.17699,1.1911461353302002,2.51156,1.0295598534578836,2.3442749999999997,1.603274926728942,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.023,0.0227,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.87,H,-0.3301,0.0424,-22.2273,-7.90930635631685,0.8649307561841211,Pathogenic,0.972,pathogenic,-4.159,available,https://doi.org/10.1101/2022.10.22.513328 +E286T,NP_000537:p.Glu286Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.26189,1.1904405355453491,2.30646,0.591687398331265,2.2841750000000003,1.4267886991656327,Uncertain,Uncertain,Uncertain,Uncertain,Neutral,False,0.023,0.0227,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,DOWN,destabilizing,neutral,False,neutral,neutral,95.87,H,-0.346,0.0424,-22.2273,-7.90930635631685,0.8092552299023816,Pathogenic,0.9508,pathogenic,-4.1,available,https://doi.org/10.1101/2022.10.22.513328 +E286V,NP_000537:p.Glu286Val,"hg19,17:g.7577081T>A, hg19,17:g.7673763T>A, hg38,17:g.7673763T>A",,,0.916,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",376592,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.59431,0.9887835383415222,1.12245,-0.2091015120413003,1.35838,0.6926042439793498,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.023,0.0227,-0.02639,Neutral,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.87,H,-0.3299,0.0424,-22.2273,-7.16464546047637,0.8395726865198525,Pathogenic,0.9153,pathogenic,-4.136,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E286W,NP_000537:p.Glu286Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,1.8218,1.058323860168457,2.10884,-0.4485752599985076,1.96532,0.6866123700007463,Uncertain,Neutral,Uncertain,Neutral,Neutral,False,0.023,0.01866,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.87,H,-0.3738,0.0424,-22.2273,-7.90930635631685,0.8656451988486518,Pathogenic,0.999,pathogenic,-4.624,available,https://doi.org/10.1101/2022.10.22.513328 +E286Y,NP_000537:p.Glu286Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,2.0109,1.3176655769348145,1.66054,0.1045225390962245,1.8357199999999998,1.0577112695481121,Uncertain,Uncertain,Uncertain,Neutral,Neutral,False,0.023,0.02908,,Uncertain,,Uncertain,,,Uncertain,28.6,,True,28.6,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.87,H,-0.3645,0.0424,-22.2273,-7.90930635631685,0.8702551529493752,Pathogenic,0.9951,pathogenic,-4.462,available,https://doi.org/10.1101/2022.10.22.513328 +E287A,NP_000537:p.Glu287Ala,"hg38,17:g.7673760T>G",,,0.562,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.14653,-0.1002238392829895,-0.27347,0.142563824277847,-0.21,-0.0019830878610764963,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.02412,-0.02112,Neutral,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.03,H,-0.0959,1.5384,-5.9307,-2.68319937612633,0.0003168862573925,Benign,0.1824,benign,-3.33,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E287C,NP_000537:p.Glu287Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.50882,-0.0382131934165954,0.28946,0.8960860617875424,0.39914000000000005,0.7024530308937712,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.0111,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.03,H,-0.1725,1.5384,-7.3457,-2.84916746173766,0.030367191050473,Benign,0.8447,pathogenic,-3.856,available,https://doi.org/10.1101/2022.10.22.513328 +E287D,NP_000537:p.Glu287Asp,"hg19,17:g.7577077C>A, hg19,17:g.7577077C>G, hg19,17:g.7673759C>A, hg19,17:g.7673759C>G, hg38,17:g.7673759C>A, hg38,17:g.7673759C>G",,7.9527922254e-06,0.405,"cBioPortal,COSMIC,ClinVar,ClinVar,saturation_mutlist","925213, 422130","Uncertain significance, Conflicting classifications of pathogenicity","2, 1",Uncertain significance,1,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.33049,0.1946367621421814,0.26633,0.4560049192162818,0.29841,0.3932474596081409,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.01412,0.01253,Neutral,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.03,H,-0.0349,1.5384,-0.7019,-0.540707185298792,7.0503704975414175e-09,Benign,0.0988,benign,-2.902,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E287F,NP_000537:p.Glu287Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.08303,0.2735913395881653,0.05476,-0.0799442083726764,-0.014135000000000002,-0.0814871041863382,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.0071,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.03,H,-0.226,1.5384,-22.2185,-3.90067976443282,0.0878927624445562,Benign,0.8277,pathogenic,-3.972,available,https://doi.org/10.1101/2022.10.22.513328 +E287G,NP_000537:p.Glu287Gly,"hg38,17:g.7673760T>C",,,0.626,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.63098,0.4378668963909149,0.67823,0.7743887623001267,0.654605,0.7026843811500634,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.01248,0.02685,Neutral,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.03,H,-0.1267,1.5384,-6.9307,-3.2298702077559,0.0035545860353111,Benign,0.1655,benign,-3.454,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E287H,NP_000537:p.Glu287His,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.14666,0.2129562497138977,-0.02755,-0.0865788983220433,0.059555000000000004,0.030040550838978358,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.00712,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.03,H,-0.2173,1.5384,-22.2185,-5.51492422806166,0.4623994728204355,Uncertain,0.6192,pathogenic,-4.066,available,https://doi.org/10.1101/2022.10.22.513328 +E287I,NP_000537:p.Glu287Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.22717,0.0191423296928405,-0.31599,-0.0976335891414159,-0.04440999999999999,0.06476820542929206,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.0364,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.03,H,-0.1584,1.5384,-7.9307,-2.97579347758502,0.0127123005449336,Benign,0.4845,ambiguous,-3.718,available,https://doi.org/10.1101/2022.10.22.513328 +E287K,NP_000537:p.Glu287Lys,"hg19,17:g.7577079C>T, hg19,17:g.7673761C>T, hg38,17:g.7673761C>T",,3.9765226105e-06,0.583,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",141781,Conflicting classifications of pathogenicity,1,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.13757,-0.151654839515686,-0.27789,0.013802951803104,-0.20773000000000003,-0.061883524098447995,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.012,0.03173,Neutral,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.03,H,-0.1281,1.5384,-7.9307,-1.38336550309718,0.0019031646392758,Benign,0.2975,benign,-3.661,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E287L,NP_000537:p.Glu287Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.31235,-0.1161352396011352,-0.36361,-0.3659188089176718,-0.33798,-0.3391344044588359,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,-0.00064,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.03,H,-0.1657,1.5384,-8.9306,-3.34721155456983,0.0108025597542791,Benign,0.4856,ambiguous,-3.721,available,https://doi.org/10.1101/2022.10.22.513328 +E287M,NP_000537:p.Glu287Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.35127,-0.107566237449646,-0.0949,-0.0262565962369848,-0.223085,-0.1887632981184924,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,-0.00348,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.03,H,-0.1823,1.5384,-22.2185,-4.58454873948403,0.2404380469519403,Benign,0.5104,ambiguous,-3.847,available,https://doi.org/10.1101/2022.10.22.513328 +E287N,NP_000537:p.Glu287Asn,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.22756,0.1722772717475891,-0.17449,0.1945477588377819,-0.201025,-0.016506120581109063,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.01268,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.03,H,-0.1323,1.5384,-7.9307,-1.71141821259126,0.0103066570062662,Benign,0.2722,benign,-3.534,available,https://doi.org/10.1101/2022.10.22.513328 +E287P,NP_000537:p.Glu287Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,3.32824,1.48878014087677,7.81361,5.812691850203367,5.570925,4.570465925101684,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.027,-0.0052,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.03,H,-0.336,1.5384,-22.2185,-5.98346379312948,0.4699580654786057,Uncertain,0.9618,pathogenic,-4.224,available,https://doi.org/10.1101/2022.10.22.513328 +E287Q,NP_000537:p.Glu287Gln,"hg19,17:g.7577079C>G, hg19,17:g.7673761C>G, hg38,17:g.7673761C>G",,,0.623,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.19172,-0.112790822982788,-0.18129,0.2251523116002668,-0.186505,0.0167161558001334,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.01096,-0.01239,Neutral,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.03,H,-0.0718,1.5384,-6.6088,-1.86040094675046,0.0045154223733136,Benign,0.2004,benign,-3.418,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E287R,NP_000537:p.Glu287Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.14712,-0.1151849031448364,-0.16361,-0.2649929696675418,-0.155365,-0.20605648483377093,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,-0.01068,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.03,H,-0.1937,1.5384,-8.9306,-3.35333267750453,0.0026107397299404,Benign,0.4529,ambiguous,-3.744,available,https://doi.org/10.1101/2022.10.22.513328 +E287S,NP_000537:p.Glu287Ser,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.35921,0.1263177990913391,-0.11327,0.5524128336176487,0.12297,0.4558114168088243,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.01896,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.03,H,-0.1047,1.5384,-5.0238,-2.47189389597539,8.32042712956667e-05,Benign,0.277,benign,-3.334,available,https://doi.org/10.1101/2022.10.22.513328 +E287T,NP_000537:p.Glu287Thr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.18594,0.2557932734489441,-0.22789,0.2914590022872321,-0.20691500000000002,0.05275950114361605,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.01152,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,95.03,H,-0.1354,1.5384,-7.9307,-2.76941398254902,0.017014020593624,Benign,0.3237,benign,-3.554,available,https://doi.org/10.1101/2022.10.22.513328 +E287V,NP_000537:p.Glu287Val,"hg38,17:g.7673760T>A",,,0.644,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,0.58653,0.2054064273834228,-0.06599,-0.0253866944976866,0.26027,0.2805716527511567,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,-0.00964,-0.12595,Neutral,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,95.03,H,-0.1922,1.5384,-22.2185,-4.95686971720322,0.1484730324608424,Benign,0.3116,benign,-3.922,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +E287W,NP_000537:p.Glu287Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.08539,0.1917762756347656,-0.37653,-0.4985303145424008,-0.23096,-0.2919601572712004,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.02614,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.03,H,-0.2361,1.5384,-22.2185,-5.51492422806166,0.6901302658969299,Pathogenic,0.9127,pathogenic,-4.302,available,https://doi.org/10.1101/2022.10.22.513328 +E287Y,NP_000537:p.Glu287Tyr,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),2.60.40.720,-0.06338,0.2873212099075317,-0.06429,-0.01339552422979,-0.063835,-0.038387762114895,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.027,0.0308,,Uncertain,,Uncertain,,,Uncertain,94.7,,True,94.7,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,95.03,H,-0.2268,1.5384,-22.2185,-5.51492422806166,0.4490908828313668,Uncertain,0.6695,pathogenic,-4.074,available,https://doi.org/10.1101/2022.10.22.513328 +N288A,NP_000537:p.Asn288Ala,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.08311,-0.001182198524475,0.07041,0.1005116203592837,-0.0063500000000000015,0.008700810179641846,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.0752,,Uncertain,-0.01911,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.39,H,-0.1154,1.5821,-8.9247,-1.97776969900807,0.0560701684058706,Benign,0.5559,ambiguous,-3.265,available,https://doi.org/10.1101/2022.10.22.513328 +N288C,NP_000537:p.Asn288Cys,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.50716,-0.0050939917564392,0.41769,0.7729735379217889,0.46242500000000003,0.6400667689608945,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.0878,,Uncertain,-0.01911,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.39,H,-0.2331,1.5821,-22.2125,-3.0392913194599,0.8229463801093728,Pathogenic,0.6331,pathogenic,-3.706,available,https://doi.org/10.1101/2022.10.22.513328 +N288D,NP_000537:p.Asn288Asp,"hg19,17:g.7577076T>C, hg38,17:g.7673758T>C",,,0.513,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1024822,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),,0.57071,0.3292179703712463,0.61361,0.180724455989904,0.59216,0.375717227994952,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,0.01132,-0.0516,Neutral,-0.06427,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.39,H,-0.1864,1.5821,-22.2125,-3.55350596031586,0.4389726511698135,Uncertain,0.7619,pathogenic,-3.63,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N288E,NP_000537:p.Asn288Glu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.06852,0.2109661698341369,0.31667,0.0782321566251431,0.19259500000000002,0.07337607831257155,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.0493,,Uncertain,-0.11507,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.39,H,-0.2135,1.5821,-22.2125,-3.09649044635862,0.2518849935410834,Benign,0.8884,pathogenic,-3.542,available,https://doi.org/10.1101/2022.10.22.513328 +N288F,NP_000537:p.Asn288Phe,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.23376,0.2836284041404724,0.13469,-0.0983827506745926,-0.049534999999999996,-0.1660713753372963,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.30344,,Uncertain,0.11106,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.39,H,-0.2403,1.5821,-22.2125,-3.87100364189457,0.8039172021829037,Pathogenic,0.825,pathogenic,-3.887,available,https://doi.org/10.1101/2022.10.22.513328 +N288G,NP_000537:p.Asn288Gly,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.77731,0.5032734870910645,1.0602,0.7942745220957559,0.918755,0.7857922610478779,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.07312,,Uncertain,-0.01852,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.39,H,-0.1462,1.5821,-8.9247,-3.60102186334272,0.3833029398647519,Uncertain,0.5693,pathogenic,-3.531,available,https://doi.org/10.1101/2022.10.22.513328 +N288H,NP_000537:p.Asn288His,"hg38,17:g.7673758T>G",,,0.554,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,0.11343,0.1434354782104492,0.2102,-0.1277163377652634,0.161815,-0.007143168882631695,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.0045,-0.05809,Neutral,0.2839,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.39,H,-0.0887,1.5821,-2.7154,-2.24138614304595,0.0307187013914106,Benign,0.3465,ambiguous,-3.337,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N288I,NP_000537:p.Asn288Ile,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.16215,0.0207706689834594,-0.27143,-0.1976073969262382,-0.21678999999999998,-0.1798786984631191,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.15626,,Uncertain,0.00742,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.39,H,-0.2335,1.5821,-22.2125,-4.25192970650052,0.7443999092140644,Pathogenic,0.4629,ambiguous,-3.666,available,https://doi.org/10.1101/2022.10.22.513328 +N288K,NP_000537:p.Asn288Lys,"hg38,17:g.7673756A>T",,,0.679,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,-0.4195,-0.2225770950317382,-0.58027,-0.0713744577792468,-0.49988499999999997,-0.24543722888962338,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,0.02206,0.12908,Neutral,-0.40866,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.39,H,-0.1105,1.5821,-7.3398,-3.052549217434,0.0136355789763751,Benign,0.7253,pathogenic,-3.22,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N288L,NP_000537:p.Asn288Leu,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.34425,-0.0506564378738403,-0.43197,-0.5630662034065576,-0.38811,-0.4536581017032788,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.16898,,Uncertain,0.08423,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.39,H,-0.2399,1.5821,-22.2125,-4.07196036192907,0.5398281199790643,Uncertain,0.5194,ambiguous,-3.462,available,https://doi.org/10.1101/2022.10.22.513328 +N288M,NP_000537:p.Asn288Met,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.59747,-0.0764492750167846,0.00272,-0.1922091370464146,-0.29737499999999994,-0.3948395685232073,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.1496,,Uncertain,0.01371,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.39,H,-0.194,1.5821,-22.2125,-4.38033927386804,0.5413369731008651,Uncertain,0.5235,ambiguous,-3.702,available,https://doi.org/10.1101/2022.10.22.513328 +N288P,NP_000537:p.Asn288Pro,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,3.01744,1.8105106353759768,4.77755,4.722480457230748,3.897495,3.8699602286153745,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.041,-0.0577,,Uncertain,0.01088,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.39,H,-0.3488,1.5821,-22.2125,-5.16944952456907,0.8172289364057981,Pathogenic,0.9558,pathogenic,-3.843,available,https://doi.org/10.1101/2022.10.22.513328 +N288Q,NP_000537:p.Asn288Gln,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.25266,-0.0785658359527587,0.16667,0.1782920432986051,-0.04299499999999999,-0.03718397835069745,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,0.02418,,Uncertain,-0.01508,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.39,H,-0.1094,1.5821,-8.9247,-2.46228200489392,0.1263507475205952,Benign,0.7269,pathogenic,-3.359,available,https://doi.org/10.1101/2022.10.22.513328 +N288R,NP_000537:p.Asn288Arg,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.42784,-0.2762683629989624,-0.54456,-0.2919746957397756,-0.4862,-0.35990734786988776,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,0.05036,,Uncertain,-0.63292,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.39,H,-0.2186,1.5821,-22.2125,-3.75938809544395,0.3173898136908225,Benign,0.8063,pathogenic,-3.446,available,https://doi.org/10.1101/2022.10.22.513328 +N288S,NP_000537:p.Asn288Ser,"hg19,17:g.7577075T>C, hg38,17:g.7673757T>C",,,0.480,"cBioPortal,COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,-0.14012,0.1092716455459594,-0.25374,0.3961685941772264,-0.19693,0.12802429708861318,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.07002,-0.01216,Neutral,-0.01922,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,93.39,H,-0.0457,1.5821,-1.1699,-1.68739472070371,0.0007251149522593,Benign,0.3389,benign,-3.116,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +N288T,NP_000537:p.Asn288Thr,"hg19,17:g.7577075T>G, hg38,17:g.7673757T>G",,,0.633,"ClinVar,saturation_mutlist",2119726,Uncertain significance,1,,,,,P53 DNA-binding domain (PF00870),,0.53093,0.2344443202018737,0.39592,0.1819649020299246,0.463425,0.35644745101496234,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.09654,0.12094,Neutral,-0.02294,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,93.39,H,-0.1349,1.5821,-8.9247,-1.62953906750738,0.0128943147429907,Benign,0.3614,ambiguous,-3.288,available,https://doi.org/10.1101/2022.10.22.513328 +N288V,NP_000537:p.Asn288Val,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,0.30831,0.1488929390907287,0.35476,-0.0947890994201544,0.331535,0.10676045028992279,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.1316,,Uncertain,-0.01911,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.39,H,-0.2268,1.5821,-22.2125,-4.21045404651123,0.6651732990723527,Uncertain,0.4933,ambiguous,-3.726,available,https://doi.org/10.1101/2022.10.22.513328 +N288W,NP_000537:p.Asn288Trp,,,,,saturation_mutlist,,,,,,,,P53 DNA-binding domain (PF00870),,-0.51787,0.2920394539833069,-0.06463,-0.5688999788349436,-0.29125,-0.5433849894174718,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,0.4899,,Uncertain,-0.01877,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.39,H,-0.2454,1.5821,-22.2125,-3.87100364189457,0.8570869970793673,Pathogenic,0.9465,pathogenic,-4.02,available,https://doi.org/10.1101/2022.10.22.513328 +N288Y,NP_000537:p.Asn288Tyr,"hg38,17:g.7673758T>A",,,0.665,"COSMIC,saturation_mutlist",,,,,,,,P53 DNA-binding domain (PF00870),,-0.20406,0.2926502823829651,-0.05102,-0.0374979188571722,-0.12754,-0.1207789594285861,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.041,-0.11294,0.07025,Neutral,-0.01369,Neutral,,,Uncertain,84.4,,True,84.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,93.39,H,-0.2239,1.5821,-22.2125,-3.87100364189457,0.8646730915720673,Pathogenic,0.413,ambiguous,-3.904,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L289A,NP_000537:p.Leu289Ala,,,,,saturation_mutlist,,,,,,,,,,0.34683,0.4935398697853088,0.79796,1.3406538027347004,0.572395,0.8437419013673502,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.0,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.91,H,-0.1197,2.3911,-6.5999,-1.91278806690408,3.302136100609804e-07,Benign,0.0997,benign,-2.912,available,https://doi.org/10.1101/2022.10.22.513328 +L289C,NP_000537:p.Leu289Cys,,,,,saturation_mutlist,,,,,,,,,,0.48965,0.36501544713974,0.63129,1.7972388456300814,0.56047,1.1434444228150407,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.0,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.91,H,-0.1127,2.3911,-7.3368,-1.70623494455017,1.3646753178569665e-06,Benign,0.1263,benign,-2.998,available,https://doi.org/10.1101/2022.10.22.513328 +L289D,NP_000537:p.Leu289Asp,,,,,saturation_mutlist,,,,,,,,,,0.69009,0.7831388711929321,1.39218,1.5952947714479575,1.041135,1.1426923857239788,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,-0.00168,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.91,H,-0.3209,2.3911,-22.2096,-2.95977493375603,0.0004262955400523,Benign,0.2548,benign,-3.344,available,https://doi.org/10.1101/2022.10.22.513328 +L289E,NP_000537:p.Leu289Glu,,,,,saturation_mutlist,,,,,,,,,,0.67194,0.7763988971710205,1.34048,1.4021616913505222,1.0062099999999998,1.0370508456752612,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.00992,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.91,H,-0.216,2.3911,-7.9218,-2.90914507739932,0.0001176390725746,Benign,0.165,benign,-3.244,available,https://doi.org/10.1101/2022.10.22.513328 +L289F,NP_000537:p.Leu289Phe,"hg19,17:g.7577073G>A, hg38,17:g.7673755G>A",,,0.344,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",822635,Conflicting classifications of pathogenicity,1,,,,,,,0.25768,0.366696298122406,1.05544,0.7885691232320741,0.65656,0.523124561616037,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.0,0.23851,Neutral,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,91.91,H,-0.0289,2.3911,-1.8558,-0.0518649406727437,1.3259010445877645e-17,Benign,0.045,benign,-2.769,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L289G,NP_000537:p.Leu289Gly,,,,,saturation_mutlist,,,,,,,,,,0.71895,0.9733063578605652,1.28571,1.934494118176944,1.00233,1.326722059088472,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.0,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.91,H,-0.2064,2.3911,-8.9217,-4.45423768418131,0.0010703884232121,Benign,0.1814,benign,-3.312,available,https://doi.org/10.1101/2022.10.22.513328 +L289H,NP_000537:p.Leu289His,,,,,saturation_mutlist,,,,,,,,,,0.47041,0.5538142919540405,-0.22755,1.028879140443013,0.12143,0.7496445702215065,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.00012,0.02676,Neutral,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.91,H,-0.1637,2.3911,-6.9218,-1.24336967944645,2.6568607771408306e-08,Benign,0.068,benign,-2.896,available,https://doi.org/10.1101/2022.10.22.513328 +L289I,NP_000537:p.Leu289Ile,"hg19,17:g.7577073G>T, hg38,17:g.7673755G>T",,,0.349,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",1439164,Conflicting classifications of pathogenicity,1,,,,,,,0.62345,0.212956428527832,-0.07279,0.902246181753164,0.27532999999999996,0.762848090876582,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,-0.01232,0.12765,Neutral,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,91.91,H,0.0338,2.3911,-1.2007,-1.60048211038511,3.6485715389777325e-05,Benign,0.0693,benign,-2.953,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L289K,NP_000537:p.Leu289Lys,,,,,saturation_mutlist,,,,,,,,,,-0.22693,0.5990318059921265,0.18197,1.1696480199356885,-0.02248,0.47135900996784424,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,-0.0024,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,91.91,H,-0.2048,2.3911,-5.9218,-2.24982461265809,5.379416805166446e-07,Benign,0.1533,benign,-3.06,available,https://doi.org/10.1101/2022.10.22.513328 +L289M,NP_000537:p.Leu289Met,,,,,saturation_mutlist,,,,,,,,,,-0.38607,0.1932848691940307,0.49014,0.7850843914523287,0.052035,0.19950719572616432,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.0,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,-,uncertain,neutral,False,neutral,neutral,91.91,H,-0.0238,2.3911,-7.9218,-2.12240502187225,3.114518312370854e-06,Benign,0.0799,benign,-3.114,available,https://doi.org/10.1101/2022.10.22.513328 +L289N,NP_000537:p.Leu289Asn,,,,,saturation_mutlist,,,,,,,,,,0.46063,0.7074981927871704,0.89966,1.1394640663188569,0.680145,0.8000470331594285,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,-0.04628,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.91,H,-0.1891,2.3911,-6.9218,-2.24758048965414,8.3340997540258e-08,Benign,0.1383,benign,-3.009,available,https://doi.org/10.1101/2022.10.22.513328 +L289P,NP_000537:p.Leu289Pro,"hg19,17:g.7577072A>G, hg38,17:g.7673754A>G",,,0.518,"COSMIC,ClinVar,saturation_mutlist",1172923,Likely benign,3,,,,,,,4.19068,1.1075032949447632,5.55,6.527477072783891,4.870340000000001,5.359078536391946,Destabilizing,Destabilizing,Uncertain,Destabilizing,Destabilizing,False,0.05,-0.01444,0.00354,Neutral,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.91,H,-0.2149,2.3911,-8.9217,-3.21706676650494,0.0025888532731495,Benign,0.5712,pathogenic,-3.338,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L289Q,NP_000537:p.Leu289Gln,,,,,saturation_mutlist,,,,,,,,,,0.23478,0.5406239032745361,0.31837,1.145442922692513,0.276575,0.6901114613462564,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,-0.00048,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.91,H,-0.1421,2.3911,-6.9218,-2.05387898137269,2.127024279428295e-07,Benign,0.0722,benign,-2.972,available,https://doi.org/10.1101/2022.10.22.513328 +L289R,NP_000537:p.Leu289Arg,"hg38,17:g.7673754A>C",,,0.426,"COSMIC,saturation_mutlist",,,,,,,,,,-0.13965,0.6087085604667664,-0.22347,0.8465342663888339,-0.18156,0.353442133194417,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.01682,-0.0414,Neutral,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,91.91,H,-0.2015,2.3911,-6.9218,-2.0685432144847,2.2452354781232724e-06,Benign,0.0864,benign,-3.074,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L289S,NP_000537:p.Leu289Ser,,,,,saturation_mutlist,,,,,,,,,,0.02499,0.6750255227088928,0.82483,1.6952755521649046,0.42490999999999995,0.8601327760824523,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.0,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.91,H,-0.1395,2.3911,-4.5295,-0.684918839668213,9.875814785988222e-10,Benign,0.1004,benign,-2.84,available,https://doi.org/10.1101/2022.10.22.513328 +L289T,NP_000537:p.Leu289Thr,,,,,saturation_mutlist,,,,,,,,,,0.67011,0.7666237950325012,0.61871,1.6193599828796064,0.6444099999999999,1.1447349914398033,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,-0.0147,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.91,H,-0.1347,2.3911,-8.9217,-1.87781748568653,2.488889226828999e-05,Benign,0.1149,benign,-3.085,available,https://doi.org/10.1101/2022.10.22.513328 +L289V,NP_000537:p.Leu289Val,"hg19,17:g.7577073G>C, hg38,17:g.7673755G>C",,,0.399,"cBioPortal,COSMIC,ClinVar,saturation_mutlist",496049,Conflicting classifications of pathogenicity,1,,,,,,,0.97287,0.4684573411941528,1.09286,1.007423352011488,1.032865,0.990146676005744,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.005,0.07624,Neutral,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,DOWN,stabilizing,neutral,False,neutral,neutral,91.91,H,-0.0368,2.3911,-7.9218,-1.62282686049212,2.151504363397156e-06,Benign,0.064,benign,-3.002,available,https://doi.org/10.1101/2022.10.22.513328; 37085483 +L289W,NP_000537:p.Leu289Trp,,,,,saturation_mutlist,,,,,,,,,,0.32417,0.2407034039497375,0.72959,0.5747861389263886,0.52688,0.44947806946319435,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,0.0,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,91.91,H,-0.2319,2.3911,-22.2096,-2.81518494983562,0.0524256575702248,Benign,0.0886,benign,-3.415,available,https://doi.org/10.1101/2022.10.22.513328 +L289Y,NP_000537:p.Leu289Tyr,,,,,saturation_mutlist,,,,,,,,,,0.10494,0.2951938509941101,0.52177,0.9995262215904294,0.313355,0.5522331107952146,Neutral,Neutral,Neutral,Neutral,Neutral,False,0.05,2e-05,,Uncertain,,Uncertain,,,Uncertain,61.4,,True,61.4,,neutral,neutral,neutral,UP,neutral,neutral,False,neutral,neutral,91.91,H,-0.1277,2.3911,-3.167,-0.545901498345077,4.4341865407177116e-08,Benign,0.0849,benign,-2.936,available,https://doi.org/10.1101/2022.10.22.513328 diff --git a/dot_plot/examples_v2/simple_mode_popeve/dictionary.csv b/dot_plot/examples_v2/simple_mode_popeve/dictionary.csv new file mode 100644 index 0000000..997026d --- /dev/null +++ b/dot_plot/examples_v2/simple_mode_popeve/dictionary.csv @@ -0,0 +1,178 @@ +#ClinVar Internal_dictionary +Benign Benign +nan Uncertain +Uncertain significance,not specified Uncertain +Uncertain significance,Pathogenic Conflicting interpretation +Conflicting interpretations of pathogenicity Conflicting interpretation +Uncertain significance,Likely pathogenic,Likely pathogenic Conflicting interpretation +Conflicting interpretations of pathogenicity,Conflicting interpretations of pathogenicity Conflicting interpretation +Conflicting interpretations of pathogenicity,Uncertain significance Conflicting interpretation +Uncertain significance,Uncertain significance,Conflicting interpretations of pathogenicity Conflicting interpretation +Uncertain significance,Conflicting interpretations of pathogenicity,Uncertain significance Conflicting interpretation +Pathogenic/Likely pathogenic,Conflicting interpretations of pathogenicity Conflicting interpretation +Conflicting interpretations of pathogenicity,Pathogenic/Likely pathogenic Conflicting interpretation +Likely benign,Likely benign,Conflicting interpretations of pathogenicity Conflicting interpretation +Likely pathogenic,Uncertain significance,Pathogenic/Likely pathogenic Conflicting interpretation +Uncertain significance,Likely pathogenic Conflicting interpretation +Conflicting interpretations of pathogenicity,Conflicting interpretations of pathogenicity,Conflicting interpretations of pathogenicity Conflicting interpretation +Uncertain significance,Uncertain significance,Likely pathogenic Conflicting interpretation +Uncertain significance,Conflicting interpretations of pathogenicity,Likely pathogenic Conflicting interpretation +Uncertain significance,Pathogenic/Likely pathogenic Conflicting interpretation +Likely benign,Conflicting interpretations of pathogenicity Conflicting interpretation +Uncertain significance,Likely benign Conflicting interpretation +Uncertain significance,Conflicting interpretations of pathogenicity,Conflicting interpretations of pathogenicity Conflicting interpretation +Pathogenic,Conflicting interpretations of pathogenicity Conflicting interpretation +Likely benign,Uncertain significance Conflicting interpretation +Likely pathogenic,Uncertain significance Conflicting interpretation +Uncertain significance,Conflicting interpretations of pathogenicity Conflicting interpretation +Uncertain significance,Benign/Likely benign Conflicting interpretation +Uncertain significance,Likely pathogenic,Uncertain significance Conflicting interpretation +Conflicting interpretations of pathogenicity,Likely pathogenic Conflicting interpretation +Likely pathogenic,Conflicting interpretations of pathogenicity Conflicting interpretation +Pathogenic,Uncertain significance Conflicting interpretation +Likely benign Likely benign +Benign/Likely benign Likely benign +Likely benign,Benign/Likely benign Likely benign +Benign/Likely benign,Benign/Likely benign Likely benign +Likely benign,Benign Likely benign +Likely benign,Likely benign Likely benign +Pathogenic/Likely pathogenic,Pathogenic,Pathogenic Likely pathogenic +Likely pathogenic,drug response Likely pathogenic +Likely pathogenic,Pathogenic Likely pathogenic +Likely pathogenic Likely pathogenic +Pathogenic, Pathogenic/Likely pathogenic Likely pathogenic +Likely pathogenic, Likely pathogenic, drug response Likely pathogenic +Pathogenic/Likely pathogenic, Likely pathogenic Likely pathogenic +Pathogenic/Likely pathogenic Likely pathogenic +Pathogenic/Likely pathogenic, Pathogenic/Likely pathogenic Likely pathogenic +Pathogenic/Likely pathogenic; risk factor Likely pathogenic +Pathogenic, Likely pathogenic, Pathogenic Likely pathogenic +Likely pathogenic, Likely pathogenic, Likely pathogenic Likely pathogenic +Likely pathogenic, Pathogenic/Likely pathogenic Likely pathogenic +Likely pathogenic,risk factor Likely pathogenic +Pathogenic/Likely pathogenic,drug response Likely pathogenic +Likely pathogenic,Pathogenic,drug response,other Likely pathogenic +Pathogenic/Likely pathogenic,Pathogenic Likely pathogenic +Likely pathogenic,Likely pathogenic Likely pathogenic +Pathogenic,Likely pathogenic Likely pathogenic +not provided Uncertain +Pathogenic,Pathogenic,Pathogenic Pathogenic +Pathogenic,risk factor Pathogenic +Pathogenic,Pathogenic Pathogenic +Pathogenic Pathogenic +Uncertain significance,Uncertain significance,Uncertain significance Uncertain +Uncertain significance,not provided Uncertain +drug response Drug response +Uncertain significance Uncertain +Uncertain significance,Uncertain significance Uncertain +Uncertain significance,drug response Uncertain +protective Protective +not provided,Pathogenic/Likely pathogenic Likely pathogenic +Uncertain significance,not provided,not provided Uncertain +not provided,not provided,not provided Uncertain +Uncertain significance,Uncertain significance,Conflicting classifications of pathogenicity Uncertain +not provided,not provided,Uncertain significance Uncertain +Benign,Uncertain significance Uncertain +Likely benign,not provided Likely benign +not provided,Uncertain significance,Conflicting classifications of pathogenicity Uncertain +Likely pathogenic,Tier I - Strong Likely pathogenic +Likely pathogenic; drug response Likely pathogenic +Pathogenic,Pathogenic/Likely pathogenic Likely pathogenic +Conflicting classifications of pathogenicity Uncertain +Likely pathogenic,Conflicting classifications of pathogenicity Uncertain +Conflicting classifications of pathogenicity,Benign Uncertain +Likely pathogenic,Likely pathogenic,drug response Likely pathogenic +Uncertain significance,not provided,Uncertain significance Uncertain +Likely pathogenic,Pathogenic/Likely pathogenic,Pathogenic,Pathogenic Likely pathogenic +not provided,Benign Uncertain +not provided,Conflicting classifications of pathogenicity Uncertain +risk factor Risk Factor +Likely pathogenic,not provided Likely pathogenic +not provided,not provided,Conflicting classifications of pathogenicity Uncertain +Pathogenic,Likely pathogenic,Pathogenic Likely pathogenic +Uncertain significance,Benign Uncertain +not provided,Pathogenic Pathogenic +Likely pathogenic; risk factor Likely pathogenic +Conflicting interpretations of pathogenicity,Pathogenic Uncertain +Benign,Conflicting interpretations of pathogenicity Uncertain +Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity Uncertain +not provided,Conflicting classifications of pathogenicity,Uncertain significance Uncertain +Benign,Benign Benign +Benign,Likely benign Likely benign +Pathogenic/Likely pathogenic; drug response Likely pathogenic +Likely benign,Likely benign,Conflicting classifications of pathogenicity Uncertain +Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity,Likely pathogenic Uncertain +Uncertain significance; drug response Uncertain +not provided,not provided,Conflicting interpretations of pathogenicity Uncertain +Pathogenic/Likely pathogenic,Likely pathogenic Likely pathogenic +Likely oncogenic Likely pathogenic +Pathogenic/Likely pathogenic,Pathogenic/Likely pathogenic Likely pathogenic +Likely pathogenic,Likely pathogenic,drug response,Tier I - Strong Likely pathogenic +Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity,Benign Uncertain +not provided,Conflicting interpretations of pathogenicity,Uncertain significance Uncertain +Likely pathogenic,Likely pathogenic,Likely pathogenic Likely pathogenic +not provided,Conflicting interpretations of pathogenicity,Conflicting interpretations of pathogenicity Uncertain +no interpretation for the single variant,Pathogenic Pathogenic +Conflicting classifications of pathogenicity,Pathogenic Uncertain +Likely benign,Conflicting classifications of pathogenicity Uncertain +Likely benign,not provided,Conflicting classifications of pathogenicity Uncertain +other Uncertain +Conflicting classifications of pathogenicity,not provided Uncertain +Uncertain significance,Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity Uncertain +Pathogenic; risk factor Pathogenic +Pathogenic/Likely pathogenic,Pathogenic/Likely pathogenic,Pathogenic Likely pathogenic +Likely benign,Benign/Likely benign,Benign Likely benign +Likely pathogenic,Pathogenic,Pathogenic Likely pathogenic +not provided,not provided,Likely pathogenic Likely pathogenic +Benign,Conflicting classifications of pathogenicity Uncertain +Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity Uncertain +not provided,Conflicting interpretations of pathogenicity Uncertain +Conflicting interpretations of pathogenicity,Benign Uncertain +Likely benign,Pathogenic Uncertain +Conflicting classifications of pathogenicity,Uncertain significance Uncertain +Likely pathogenic,Pathogenic/Likely pathogenic,Tier I - Strong Uncertain +Uncertain significance,Uncertain significance,Likely benign Uncertain +Likely benign,Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity Uncertain +Pathogenic; other Uncertain +Pathogenic/Likely pathogenic/Pathogenic, low penetrance/Established risk allele Likely pathogenic +Benign/Likely benign,Conflicting interpretations of pathogenicity Uncertain +Likely pathogenic/Likely risk allele Likely pathogenic +Benign/Likely benign,Conflicting classifications of pathogenicity Uncertain +Conflicting classifications of pathogenicity,Pathogenic/Likely pathogenic Uncertain +Uncertain significance,other Uncertain +Conflicting interpretations of pathogenicity,Likely benign Uncertain +Conflicting classifications of pathogenicity,Likely pathogenic Uncertain +not provided,not provided,Benign Benign +Likely pathogenic,Pathogenic/Likely pathogenic Likely pathogenic +Uncertain significance; risk factor Uncertain +Pathogenic/Likely pathogenic,Conflicting classifications of pathogenicity Uncertain +Benign,Benign/Likely benign Likely benign +Conflicting classifications of pathogenicity,Uncertain significance,Uncertain significance Uncertain +Conflicting classifications of pathogenicity,Likely benign Uncertain +Likely risk allele Likely risk +Uncertain risk allele Uncertain risk +Conflicting interpretations of pathogenicity,Conflicting interpretations of pathogenicity,Benign Uncertain +Pathogenic,Pathogenic; risk factor Pathogenic +Conflicting classifications of pathogenicity; association; risk factor Uncertain +not provided,Likely pathogenic Likely pathogenic +Benign/Likely benign,Benign Likely benign +Conflicting interpretations of pathogenicity; risk factor Uncertain +not provided,Likely benign Likely benign +Uncertain significance/Uncertain risk allele Uncertain +not provided,Uncertain significance,Conflicting interpretations of pathogenicity Uncertain +Uncertain significance,Conflicting classifications of pathogenicity,Uncertain significance Uncertain +Pathogenic,Conflicting classifications of pathogenicity Uncertain +not provided,Uncertain significance Uncertain +Uncertain significance,Conflicting classifications of pathogenicity Uncertain +Likely benign,Likely benign,Benign Likely benign +Conflicting classifications of pathogenicity; risk factor Uncertain +not provided,Pathogenic,not provided Pathogenic +Pathogenic,not provided,Likely pathogenic Likely pathogenic +not provided,not provided Uncertain +not provided,Conflicting classifications of pathogenicity,Conflicting classifications of pathogenicity Uncertain +Pathogenic/Likely pathogenic,Uncertain significance,Pathogenic Uncertain +Likely pathogenic,Pathogenic; drug response; other Likely pathogenic +Benign,Likely benign,Benign Benign +Conflicting classifications of pathogenicity,Tier II - Potential Uncertain +Conflicting classifications of pathogenicity,Uncertain significance,Conflicting classifications of pathogenicity Uncertain +no interpretation for the single variant Uncertain diff --git a/dot_plot/examples_v2/simple_mode_popeve/do.sh b/dot_plot/examples_v2/simple_mode_popeve/do.sh new file mode 100644 index 0000000..b39d0e2 --- /dev/null +++ b/dot_plot/examples_v2/simple_mode_popeve/do.sh @@ -0,0 +1,2 @@ +module load python +python ../../dot_plot_v2.py -i TP53-simple_mode.csv -x 50 -pltD -pltR -pltP -colC -vep -lgof -cct germline -v dictionary.csv diff --git a/dot_plot/examples_v2/simple_mode_popeve/dot_plot.pdf b/dot_plot/examples_v2/simple_mode_popeve/dot_plot.pdf new file mode 100644 index 0000000..38aef75 Binary files /dev/null and b/dot_plot/examples_v2/simple_mode_popeve/dot_plot.pdf differ diff --git a/dot_plot/examples_v2/simple_mode_popeve/log.txt b/dot_plot/examples_v2/simple_mode_popeve/log.txt new file mode 100644 index 0000000..bac4b0a --- /dev/null +++ b/dot_plot/examples_v2/simple_mode_popeve/log.txt @@ -0,0 +1,127 @@ +Summary of the effects. + +>>> UNCERTAIN effects: + +- 0 variants remain uncertain for Stability (ThermoMPNN, alphafold, kcal/mol). [] +- 1062 variants remain uncertain for Stability classification, alphafold, (Rosetta, FoldX). See csv file for details. +- 1111 variants remain uncertain for Stability classification, alphafold, (RaSP, FoldX). See csv file for details. +- 1025 variants remain uncertain for Stability classification, alphafold, (ThermoMPNN). See csv file for details. +- 441 variants remain uncertain for Stability classification, alphafold, (Foldetta from FoldX and Rosetta). See csv file for details. +- 363 variants remain uncertain for Stability classification, alphafold, (Foldetta from FoldX and RaSP). See csv file for details. +- 1868 variants remain uncertain for LOCAL_INTERACTION ['TP53BP1_AFmulti']. See csv file for details. +- 1596 variants remain uncertain for LOCAL_INTERACTION with DNA ['3KZ8b']. See csv file for details. +- 1939 variants remain uncertain for LOCAL_INTERACTION ['TP53_2OCJbd']. See csv file for details. +- 14 variants remain uncertain for PTM-stability. See csv file for details. + - 629 variants remain uncertain for PTM-regulation. See csv file for details. + - 114 variants remain uncertain for PTM-function. See csv file for details. + - 375 variants couldn't be assessed with the LONG_RANGE [' pockets and interfaces'] module due to small changes in side-chain volume upon mutation. See csv file for details. +- 0 variants couldn't be assessed with the functional site ['cofactor'] module [] +- No classification for Long Range-PSN available yet. +- 0 variants could not be classified with any of the MAVISp modules.[] + +>>> DAMAGING/DESTABILIZING effects: + +- 0 variants are predicted with damaging effects for Stability (ThermoMPNN, alphafold, kcal/mol). [] +-- 0 of these are vus according to ClinVar Germline Interpretation: [] +-- 0 of these have conflicting interpretations according to ClinVar Germline Interpretation: [] +- 597 variants are predicted with damaging effects for Stability classification, alphafold, (Rosetta, FoldX). See csv file for details. +-- 24 of these are vus according to ClinVar Germline Interpretation: See csv file for details. +-- 69 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 460 variants are predicted with damaging effects for Stability classification, alphafold, (RaSP, FoldX). See csv file for details. +-- 23 of these are vus according to ClinVar Germline Interpretation: See csv file for details. +-- 51 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 723 variants are predicted with damaging effects for Stability classification, alphafold, (ThermoMPNN). See csv file for details. +-- 47 of these are vus according to ClinVar Germline Interpretation: See csv file for details. +-- 66 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 856 variants are predicted with damaging effects for Stability classification, alphafold, (Foldetta from FoldX and Rosetta). See csv file for details. +-- 40 of these are vus according to ClinVar Germline Interpretation: See csv file for details. +-- 89 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 772 variants are predicted with damaging effects for Stability classification, alphafold, (Foldetta from FoldX and RaSP). See csv file for details. +-- 33 of these are vus according to ClinVar Germline Interpretation: See csv file for details. +-- 81 of these have conflicting interpretations according to ClinVar Germline Interpretation: See csv file for details. +- 21 variants are destabilizing for the LOCAL_INTERACTION ['TP53BP1_AFmulti']. See csv file for details. +- 68 variants are destabilizing for the LOCAL_INTERACTION with DNA ['3KZ8b']. See csv file for details. +- 8 variants are destabilizing for the LOCAL_INTERACTION ['TP53_2OCJbd']. ['H178D', 'H178L', 'H178N', 'H178P', 'H178Q', 'H178Y', 'C242W', 'M243T'] +- 69 variants are predicted with damaging effects on stability after the removal of a PTM. See csv file for details. + - 136 variants are likely to alter the regulation provided by a phosphorylation. See csv file for details. + - 133 variants are potentially damaging in terms of removing the function related to a phosphorylation. See csv file for details. +- 2297 variants are damaging for LONG_RANGE [' pockets and interfaces'] See csv file for details. +-- 337 as destabilizing See csv file for details. +-- 1541 as stabilizing See csv file for details. +-- 419 with mixed effects See csv file for details. +- 76 variants are damaging for Loss of disulfide bridge See csv file for details. +- 9 variants are damaging for Predicted de-novo disulfide bridge ['K120C', 'M133C', 'Q144C', 'W146C', 'H179C', 'G245C', 'V272C', 'A276C', 'D281C'] +- 323 variants are damaging for Functional site ['cofactor'] module See csv file for details. +- No classification for Long Range-PSN available yet. +- Variants with multiple effects: +-- R273P, C242W, G279H, R248P, G279W, D281P, G244V -> [stability, local_interactions] +-- C135E, L194G, Y205A, L194S, G154T, P151I, L130S, A159H, T211W, G245H, T211R, S94F, Y220R, R248I, G245L, V216N, L194E, L137D, C176Y, Y236G, L194T, W146G, C238R, S127R, G187V, F270S, Y234E, P151S, Y234A, L130A, Y163L, C238L, H179K, R248V, V203K, Y163P, F113S, I251T, Y205M, Y163S, R174N, Y220Q, F270Q, R174A, R249P, R267P, F134T, V97G, V218A, Y107E, V143A, P142Q, F113A, V203F, Q136P, Y163E, V197P, N131V, C238I, G226P, T211M, V272N, N235Y, T230G, Y236L, F113E, Y126M, V197W, P151R, M246Y, L111W, Y236Q, D208K, Y205L, P151W, R158D, P151Q, G262I, M160P, R158Y, F134H, V217Y, R175D, L188P, V218N, V143D, V216D, R267G, V197D, R213S, C238A, Y236N, R158P, F113I, H179Q, M237R, R282G, M160W, Y220G, I232E, S94I, V173D, S127G, G199I, S94D, R248P, R158G, V197K, R174P, F270G, Y220I, V197R, S94L, Y126I, Y163N, R110D, H179Y, H179P, R282D, G244V, T231G, C176T, Y163Q, V216S, E286P, C176L, H179R, L194P, V173G, H193R, R158F, H179A, C135W, V272P, E171P, A159I, S94Y, Q144P, V143S, A159R, Y236I, V197F, L206P, Y126C, V197S, M133K, V143T, V203W, L194N, N200G, G245P, Y103G, Y205G, C238H, L130W, R175E, G244P, V147H, V197T, L130T, Y234T, F270K, Q144G, D208G, Y107A, Y220E, Y234C, G245M, S94R, S127I, C135R, I195F, C176V, L111P, I232T, G245F, S127Y, Y107N, I251N, H179V, E285P, T211E, Y220D, R249G, Y205K, P142H, S149P, R174D, P151G, Y107G, S127L, V203R, G245A, Y107R, M246F, V173P, S127F, V203G, L289P, Y126A, S94W, Y236R, V143P, P151E, Y107C, T211K, P190G, F134C, V203P, N235F, G187P, T211L, S127W, I232P, H193P, Y126N, L137S, I251P, V216P, V217R, F113H, R174G, C176H, R110P, Y205S, S127M, L111H, V218P, F270C, C238K, V147K, M237K, C176M, F113V, L137N, F113C, V147W, Y163M, Y107V, R174L, A159Y, F134P, Y236T, V197N, Y236M, I195Y, S94N, H179S, F134D, P278A, F270T, I251S, P142G, F134N, Y234N, C176K, Y163C, F270H, G199P, F134E, Y236V, H179F, C135F, C238M, V216G, M160D, E198P, C238F, I255Q, C135K, L111Y, Y236S, L130D, R181P, L130R, I255A, Y234K, C238W, M246G, R196P, I232D, Y220K, Y103P, L111A, Y163D, I195R, P151Y, G245D, R213P, Y205W, G245V, Y236D, Y163K, M237Y, V217W, R156G, Y205T, S185P, Y107D, Y205R, A159Q, V97D, P278S, Y205P, A159D, V203Y, F113Q, M237P, C238G, R158N, V218D, Y126S, M160N, Y220N, Y163T, C176N, I255G, L130P, P151H, L194C, L194H, V147R, V217K, I255P, S94E, L111T, Y220V, Y236K, Y163H, V217F, Y234D, F134A, Y234S, F134V, C176A, I232Q, K132F, V197Y, R273G, G226I, L130Y, Y126Q, Y163R, S127H, F134R, M246S, G226C, I251E, C238N, Y107L, R282P, Y205I, G245R, G244I, Y126E, F134L, G262V, S94H, K139P, L194Q, G262P, V203D, M246H, R174S, G245S, V143N, M246K, Y220C, Y126T, I232R, G245Y, Y220H, M160Y, C176G, Y234V, F270N, L111R, Y107S, L111C, Y163I, H179M, F134K, I255T, S94Q, G154I, L130E, C176S, H179W, R273P, F134G, E180P, V173S, A159K, M133Y, R174I, F134Q, R175G, L130H, K132Y, C176F, R158E, L194A, L130N, C135Y, V272G, H179I, V218S, L111N, Y163G, T211Q, S94M, S94P, C135H, Y234R, Y126V, F270A, R156P, F270D, C176W, Y205E, F113G, Y236A, I232H, Y205N, Y107P, V216T, G112P, V122P, L194D, A159F, Y205D, S127P, Q136D, I195W, F113N, F270E, H168P, F113K, T211A, V143G, Y236H, V197A, V197H, C238T, I251C, V272S, H178E, Y234Q, M160G, F270P, R174W, Y126K, Y107I, Y126R, R282H, C238V, C176Q, T211Y, F113R, R158W, G245E, Y107Q, V203N, L111S, Y236P, H179L, E287P, S127V, G245I, Y126P, F134S, R174E, P151K, R174Q, I232S, I251A, F113T, V217H, G154P, I251D, R156D, E204P, Y205V, L111F, Y220S, I232A, E221P, M246D, R202P, M246R, M246N, G187I, C238Q, F270V, P151F, L130G, Y220A, Y126D, I255E, S127E, C238Y, R213D, H179T, K164P, K132W, G244T, F113P, T211I, I255N, A159E, Y163V, Y205C, T211V, F113D, V218G, Y126H, Y126G, I251H, L130Q, G245Q, M160K, R196D, I255D, T211H, P142E, I251G, H179N, R267D, Y220M, V173N, G245C, G245W, A138P, Y126L, V197G, M169P, G245K, A159W, I255H, M133R, L137G, Y205Q, Y236E, H193W, Y163A, L111Q, M246W, H179G, R175H, N239E, T211F, C176R, N131I, I232G, W146P, C176I, G154V, M160R, V172G, G199V, Y220T, Y107K, Y220P, V203H, L111G, I255C, P278G, V272D, I232N, V272A, Y107T, S127Q, G226V, G245N, A159P, W146D, S127K, G226T, R267N, R156E, T211G, S94K, R213G, S96P, L111E, G245T, R158H, Y234P, R267E, Y236C, L111D, I255S, G154S, F270R, I251Q, C135N, Y234G, G226A, V197M, E286G -> [stability, long_range] +-- C141F, C242Y, C238L, C141H, C238P, C238G, C141D, C238M, C238Y, C141Y, G245C, C238N, C238F, C238K, C238H, C141R, C141G, C242W, C242F, C238A, C141W, C141E, C238T, C238W, C242P, C238I, C141Q, C124P, C238R, C141P, C242D, C124K, C242H, C238V, C238Q, C141K -> [stability, disulfide] +-- V274S, L194G, L194S, C238G, L194N, H179L, G245P, C238H, C176N, R175W, G245I, G245H, R175E, V274Q, L194W, L194C, L194H, R175Y, G245L, L194E, G245M, C176A, C176V, C176Y, G245F, L194T, M246D, C238R, M246R, H179V, C242D, M246N, C238Q, M246S, C238L, H179K, C238Y, H179T, V274G, C238N, V274Y, V274F, G245R, G245A, M246F, L194Q, C176P, L194Y, M246H, G245S, M246K, V274P, C238I, G245Y, G245Q, V274T, C176G, V274E, H179M, C242W, M246Y, C176S, H179W, C242Y, V274R, H179N, V274N, C176H, G245C, E180P, C238K, R175D, G245W, R175G, C176M, C176F, V274H, L194A, C238A, G245K, L194K, H179I, H179Q, H179S, C176W, R175H, H179G, M246W, N239E, C176R, C176I, V274D, C176K, S240P, V274W, L194D, C238P, H179F, C238M, H179Y, C238F, H179P, G245N, C176T, V274K, C176L, H179R, C242F, R175F, R181P, L194P, C238T, C238W, M246G, G245T, H178E, C242P, V274A, C182P, G245D, G245V, H179A, C242H, C238V, C176Q, L194R, G245E -> [stability, functional site] +-- Y126C, Y126D, T211E, Y220M, S149P, Y126S, T211W, Y126P, T211I, T211R, Y126E, T211A, T211G, Y126A, T211P, T211V, T211K, Y126H, T211Q, Y126V, Y126G, Y126T, T211L, Y126K, T211F, T284P, T211M, Y126N, Y126R, T211Y, Y126Q, S185P, T211H -> [stability, ptm] +-- K120E, R273P, G244E, K120G, K120N, G244V, D281A, M243T, R248C, H178Y, C275K, H178D, C275R, W91S, K120Q, D281G, N239M, D281S, H178N, K120H, H178L, C275Y, R248G, H178P, G244D, H178Q, G244C, C275T, K120P, N239Y, K120D, R248L, R273H, R248P, K120A, C275W -> [local_interactions, long_range] +-- C242W, D281C -> [local_interactions, disulfide] +-- M243T, H178L, H178N, S240F, N239Y, H178Y, H178D, H178P, S240W, C242W, H178Q, S240Y, N239M -> [local_interactions, functional site] +-- Q144C, C238S, C238L, C238G, H179C, C238M, C238Y, G245C, C238N, C238F, C238K, C238H, C124A, C238A, C238T, C238W, C124S, V272C, C238I, K120C, C238R, C124G, C238V, C242G, C238Q, C242A, W146C, C238E, C242S -> [long_range, disulfide] +-- C182V, C182T, L194G, L194S, C238G, R181Y, H178R, H179C, L194N, H179L, R181H, G245P, M243G, C238H, C176N, M243T, G245I, G245H, R175E, M246Q, H178D, L194C, C182Y, L194H, H178F, P177F, M246T, M243W, G245L, H178I, L194E, M243K, G245E, P177L, R181W, E180A, G245M, C176A, P177E, C176V, C176Y, G245F, H178C, L194T, M243R, M246D, E180H, M243V, M246A, C238R, N239K, H179V, R175Q, M246N, M246R, M243F, C238Q, P177R, C238E, M243S, H178W, M246S, R181M, H179E, C238L, H179K, H178T, H178K, C238Y, H179T, C238N, C182L, G245R, R175P, G245A, R175I, M246F, N239H, L194Q, H178A, E180I, H178L, E180Y, R181L, R181N, E180Q, E180R, M246H, C182H, M243E, G245S, P177K, N239W, M246K, M246P, P177H, R181Q, C238I, H178Q, G245Y, C182G, N239I, G245Q, C176G, N239Y, H179M, E180F, C242A, C242G, M246Y, C176S, H179W, C242S, C182F, R175A, L194V, C238S, E180D, H179N, C176H, R175T, C176E, G245C, E180P, R175C, C238K, E180L, R175D, G245W, H178Y, R175G, C176M, R175S, C176F, R181I, R175L, L194A, C182K, M246V, C238A, G245K, H179I, H178N, E180M, H179Q, R181F, R181G, H178V, P177W, E180C, H179S, R181E, C176W, R175H, H179G, C182E, N239E, P177Y, N239F, M246W, C176R, E180W, C182A, C182Q, R175M, C182S, M243Y, C176I, C176K, M243P, M243N, M243H, L194D, H179F, C238M, C182M, R181T, P177Q, P177V, H179Y, R181A, C238F, H179P, P177I, M243D, P177M, G245N, M243Q, C176T, M243A, M246C, C182N, C176L, H179R, E180K, C182R, S240G, E180G, C182W, N239Q, M243C, R181P, N239M, L194P, R175N, R181V, C238T, C238W, M246G, G245T, H178E, H178P, R181D, G245D, H178S, N239L, G245V, R181S, N239R, C182I, H179A, H178M, H179D, E180N, R181C, C238V, C176Q, M246E, N239V, E180T, H178G, R175V, E180S -> [long_range, functional site] +-- Y126C, T150R, S99W, Y126S, S269G, T211W, T150V, T150L, T150E, Y126P, S99R, T211R, S183I, S99K, S183V, S149H, S185D, S99D, S183E, T150Q, S185C, S183H, S183Q, S185F, Y126Q, S149D, S183L, S99M, Y126D, T211E, S183T, S149I, S149Q, S149M, S149P, S185E, S215G, T211I, S99P, Y126E, S99E, T150Y, S185I, T150S, S149C, Y126A, S99G, S149R, S185K, T211V, S99L, T211K, Y126H, S149T, S183Y, Y126G, S149L, T150K, S99Q, Y126T, T211L, S183C, T150W, T150I, T211M, Y126N, S185H, T150A, T150C, S149F, T211H, S183P, S185R, S185L, S185Y, Y220M, S99F, S149Y, S99H, S149W, S183M, S99C, S99I, T211C, T211Q, T150G, Y126V, S183N, S185M, S183R, S185N, T211F, S149K, S149E, T150H, S185V, S185G, T150M, S185Q, T211A, T211G, S183W, Y220L, T150F, S149N, S106G, S183D, S149V, S183G, S183F, S185W, S183K, Y126K, S99N, S99V, Y126R, T211Y, S185P, T211S, S185T -> [long_range, ptm] +-- C242Y, C238S, C238L, C238P, C238G, C242Q, H179C, C238M, C238Y, C242I, G245C, C238N, C238F, C238K, C238H, C242L, C242E, C242T, C242F, C238A, C242R, C238T, C238W, C242K, C242V, C242P, C238D, C242N, C238I, C238R, C242D, C242H, C238V, C242G, C238Q, C242A, C242M, C238E, C242W, C242S -> [disulfide, functional site] +-- R248P, G244V, R273P -> [stability, local_interactions, long_range] +-- C242W -> [stability, local_interactions, disulfide] +-- C238T, C238W, C238R, C238L, C238G, C238V, C238M, C238Q, C238N, C238Y, G245C, C238I, C238A, C238F, C238K, C238H -> [stability, long_range, disulfide] +-- L194G, L194S, C238G, L194N, H179L, G245P, C238H, C176N, G245I, G245H, R175E, L194C, L194H, G245L, L194E, G245M, C176A, C176V, C176Y, G245F, L194T, M246D, C238R, M246R, H179V, M246N, C238Q, M246S, C238L, H179K, C238Y, H179T, C238N, G245R, G245A, M246F, L194Q, M246H, G245S, M246K, C238I, G245Y, G245Q, C176G, H179M, M246Y, C176S, H179W, H179N, C176H, G245C, E180P, C238K, R175D, G245W, R175G, C176M, C176F, L194A, C238A, G245K, H179I, H179Q, H179S, C176W, R175H, H179G, M246W, N239E, C176R, C176I, C176K, L194D, H179F, C238M, H179Y, C238F, H179P, G245N, C176T, C176L, H179R, R181P, L194P, C238T, C238W, M246G, G245T, H178E, G245D, G245V, H179A, C238V, C176Q, G245E -> [stability, long_range, functional site] +-- Y126C, Y126D, T211E, Y220M, S149P, Y126S, T211W, Y126P, T211I, T211R, Y126E, T211A, T211G, Y126A, T211V, T211K, Y126H, T211Q, Y126V, Y126G, Y126T, T211L, Y126K, T211F, T211M, Y126N, Y126R, T211Y, Y126Q, S185P, T211H -> [stability, long_range, ptm] +-- C242Y, C238L, C238P, C238G, C238M, C238Y, G245C, C238N, C238F, C238K, C238H, C242F, C238A, C238T, C238W, C242P, C238I, C238R, C242D, C242H, C238V, C238Q, C242W -> [stability, disulfide, functional site] +-- M243T, H178L, H178N, N239Y, H178Y, H178D, H178P, H178Q, N239M -> [local_interactions, long_range, functional site] +-- C242W -> [local_interactions, disulfide, functional site] +-- C238S, C238L, C238G, H179C, C238M, C238Y, G245C, C238N, C238F, C238K, C238H, C238A, C238T, C238W, C238I, C238R, C238V, C242G, C238Q, C242A, C238E, C242S -> [long_range, disulfide, functional site] +-- C238T, C238W, C238R, C238L, C238G, C238V, C238M, C238Q, C238N, C238Y, G245C, C238I, C238A, C238F, C238K, C238H -> [stability, long_range, disulfide, functional site] +- We aggregated all the variants that have at least one of the MAVISp modules with a predicted damaging effect (except for PTM.function) and retained only the ones with a REVEL score higher than 0.5 for a total of 710 variants which could be of interest for further investigation: +-- ['W91R', 'P92A', 'P92S', 'L93V', 'S94L', 'S94P', 'S94T', 'S95F', 'S95T', 'S96P', 'S96Y', 'V97A', 'V97D', 'V97F', 'V97I', 'V97L', 'P98A', 'P98H', 'P98L', 'P98R', 'P98S', 'S99C', 'S99F', 'S99P', 'K101E', 'T102I', 'Y103C', 'Y103H', 'Y103N', 'Y103S', 'G105A', 'G105C', 'G105D', 'G105R', 'G105S', 'G105V', 'S106R', 'Y107C', 'Y107D', 'Y107H', 'Y107N', 'Y107S', 'G108C', 'G108D', 'G108S', 'G108V', 'F109C', 'F109I', 'F109S', 'F109V', 'F109Y', 'R110G', 'R110H', 'R110L', 'R110P', 'R110S', 'L111P', 'L111Q', 'L111R', 'F113C', 'F113L', 'F113S', 'L114V', 'H115Y', 'S116C', 'S116F', 'G117A', 'G117E', 'G117R', 'G117V', 'G117W', 'T118A', 'A119G', 'K120E', 'K120M', 'K120N', 'K120Q', 'K120T', 'S121F', 'V122A', 'V122L', 'V122M', 'T123I', 'T123S', 'C124F', 'C124G', 'C124R', 'C124S', 'C124W', 'C124Y', 'T125A', 'T125K', 'T125M', 'T125P', 'T125R', 'T125S', 'Y126C', 'Y126D', 'Y126H', 'Y126N', 'Y126S', 'S127C', 'S127F', 'S127P', 'S127T', 'S127Y', 'P128L', 'P128R', 'P128S', 'A129D', 'L130F', 'L130H', 'L130P', 'L130R', 'L130V', 'N131H', 'N131I', 'N131K', 'N131S', 'N131Y', 'K132E', 'M133K', 'M133R', 'M133T', 'F134C', 'F134I', 'F134L', 'F134S', 'F134V', 'C135F', 'C135G', 'C135R', 'C135S', 'C135W', 'C135Y', 'Q136E', 'Q136H', 'Q136K', 'Q136L', 'Q136P', 'Q136R', 'L137P', 'L137Q', 'L137V', 'A138D', 'A138P', 'A138T', 'A138V', 'K139E', 'K139N', 'K139Q', 'K139T', 'T140A', 'T140I', 'T140S', 'C141F', 'C141G', 'C141R', 'C141S', 'C141W', 'C141Y', 'P142A', 'P142H', 'P142L', 'P142R', 'P142S', 'V143A', 'V143E', 'V143G', 'Q144H', 'Q144K', 'Q144L', 'Q144P', 'Q144R', 'L145P', 'L145Q', 'L145R', 'W146C', 'W146G', 'W146S', 'V147D', 'V147F', 'V147G', 'V147I', 'D148V', 'D148Y', 'S149P', 'P151A', 'P151H', 'P151L', 'P151R', 'P151S', 'P151T', 'P152A', 'P152S', 'G154A', 'G154C', 'G154D', 'G154R', 'G154S', 'G154V', 'T155I', 'T155N', 'T155P', 'R156G', 'R156H', 'R156L', 'R156P', 'R156S', 'V157A', 'V157D', 'V157F', 'V157G', 'R158C', 'R158G', 'R158H', 'R158L', 'R158P', 'R158S', 'A159D', 'A159P', 'A159T', 'A159V', 'M160K', 'M160R', 'M160T', 'M160V', 'A161D', 'I162F', 'I162N', 'I162S', 'Y163C', 'Y163D', 'Y163H', 'Y163N', 'Y163S', 'K164E', 'K164M', 'K164N', 'K164Q', 'K164T', 'Q165E', 'Q165P', 'S166L', 'S166P', 'S166T', 'Q167H', 'Q167K', 'Q167L', 'Q167P', 'Q167R', 'H168D', 'H168L', 'H168N', 'H168P', 'H168Q', 'H168R', 'H168Y', 'M169T', 'M169V', 'T170A', 'T170K', 'T170M', 'T170R', 'T170S', 'E171A', 'E171D', 'E171G', 'V172A', 'V172D', 'V172F', 'V172G', 'V173A', 'V173E', 'V173G', 'V173M', 'R174G', 'R174M', 'R174S', 'R174T', 'R174W', 'R175C', 'R175G', 'R175H', 'R175L', 'R175P', 'R175S', 'C176F', 'C176G', 'C176R', 'C176S', 'C176W', 'C176Y', 'P177H', 'P177L', 'P177R', 'H178D', 'H178L', 'H178N', 'H178P', 'H178Q', 'H178R', 'H178Y', 'H179D', 'H179L', 'H179N', 'H179P', 'H179Q', 'H179R', 'H179Y', 'E180D', 'E180G', 'E180K', 'E180Q', 'R181C', 'R181G', 'R181H', 'R181L', 'R181P', 'R181S', 'C182G', 'C182R', 'C182W', 'C182Y', 'S183L', 'D184E', 'D184G', 'D184H', 'D184Y', 'S185R', 'D186E', 'D186G', 'D186H', 'D186V', 'G187A', 'G187C', 'G187D', 'G187R', 'G187S', 'G187V', 'L188P', 'L188Q', 'L188V', 'A189D', 'A189G', 'A189P', 'P190A', 'P190H', 'P190L', 'P190R', 'P190S', 'P190T', 'P191A', 'P191H', 'P191L', 'P191R', 'P191S', 'Q192E', 'Q192H', 'Q192K', 'Q192L', 'Q192P', 'Q192R', 'H193D', 'H193L', 'H193N', 'H193P', 'H193Q', 'H193R', 'H193Y', 'L194H', 'L194P', 'L194R', 'L194V', 'I195F', 'I195N', 'I195S', 'I195T', 'R196G', 'R196L', 'R196P', 'R196Q', 'V197A', 'V197E', 'V197G', 'V197L', 'V197M', 'E198D', 'E198G', 'E198K', 'E198Q', 'G199A', 'G199E', 'G199R', 'G199V', 'N200H', 'N200I', 'N200S', 'N200Y', 'L201S', 'R202H', 'R202L', 'R202P', 'V203A', 'V203E', 'V203L', 'V203M', 'E204A', 'E204G', 'E204K', 'Y205C', 'Y205D', 'Y205H', 'Y205N', 'Y205S', 'L206S', 'L206W', 'D207A', 'D207G', 'D207H', 'D207Y', 'D208A', 'D208E', 'D208G', 'D208H', 'D208V', 'D208Y', 'R209G', 'R209I', 'R209S', 'R209T', 'T211A', 'T211I', 'T211N', 'T211P', 'T211S', 'R213G', 'R213L', 'R213P', 'R213Q', 'H214L', 'H214R', 'H214Y', 'S215C', 'S215G', 'S215I', 'S215T', 'V216A', 'V216E', 'V216G', 'V216M', 'V217E', 'V217G', 'V217L', 'V218A', 'V218E', 'V218G', 'P219A', 'P219S', 'Y220C', 'Y220D', 'Y220H', 'Y220N', 'Y220S', 'E221A', 'E221D', 'E221G', 'E221K', 'P222L', 'P222Q', 'P223H', 'P223L', 'P223R', 'E224A', 'E224D', 'E224G', 'E224K', 'E224Q', 'V225D', 'V225F', 'V225G', 'G226A', 'G226C', 'G226D', 'G226S', 'G226V', 'S227P', 'D228A', 'D228G', 'D228H', 'D228V', 'D228Y', 'C229G', 'C229S', 'T230A', 'T230P', 'T230S', 'T231A', 'T231I', 'T231S', 'I232F', 'I232N', 'I232S', 'I232T', 'H233D', 'H233L', 'H233P', 'H233Q', 'H233R', 'H233Y', 'Y234C', 'Y234D', 'Y234H', 'Y234N', 'Y234S', 'N235H', 'N235I', 'N235K', 'N235S', 'N235Y', 'Y236C', 'Y236D', 'Y236H', 'Y236N', 'Y236S', 'M237K', 'M237R', 'M237T', 'M237V', 'C238F', 'C238G', 'C238R', 'C238S', 'C238W', 'C238Y', 'N239H', 'N239I', 'N239K', 'N239Y', 'S240G', 'S241P', 'C242F', 'C242G', 'C242R', 'C242S', 'C242W', 'C242Y', 'M243K', 'M243R', 'M243T', 'M243V', 'G244A', 'G244C', 'G244D', 'G244R', 'G244S', 'G244V', 'G245A', 'G245C', 'G245D', 'G245R', 'G245S', 'G245V', 'M246K', 'M246R', 'M246T', 'M246V', 'N247D', 'N247I', 'N247T', 'R248G', 'R248L', 'R248P', 'R248Q', 'R249G', 'R249M', 'R249S', 'R249T', 'R249W', 'P250A', 'P250S', 'I251F', 'I251N', 'I251S', 'I251T', 'I251V', 'L252H', 'L252P', 'T253N', 'T253P', 'I254N', 'I254S', 'I254T', 'I255F', 'I255N', 'I255S', 'I255T', 'I255V', 'T256P', 'L257P', 'L257Q', 'L257R', 'E258D', 'E258G', 'E258K', 'D259A', 'D259E', 'D259G', 'D259H', 'D259V', 'D259Y', 'S260C', 'S260F', 'S260P', 'S260T', 'S260Y', 'S261G', 'G262C', 'G262D', 'G262R', 'G262S', 'G262V', 'L264R', 'L265P', 'L265Q', 'L265R', 'G266E', 'G266R', 'G266V', 'R267G', 'R267L', 'R267P', 'R267Q', 'R267W', 'S269G', 'S269I', 'S269N', 'S269R', 'S269T', 'F270C', 'F270I', 'F270L', 'F270S', 'F270V', 'V272A', 'V272E', 'V272G', 'R273C', 'R273G', 'R273H', 'R273L', 'R273P', 'R273S', 'V274A', 'V274D', 'V274F', 'V274G', 'C275F', 'C275G', 'C275R', 'C275S', 'C275W', 'C275Y', 'A276G', 'A276P', 'A276T', 'C277F', 'C277G', 'C277R', 'C277S', 'C277W', 'C277Y', 'P278A', 'P278H', 'P278L', 'P278R', 'P278S', 'P278T', 'G279A', 'G279E', 'G279R', 'G279V', 'G279W', 'R280G', 'R280I', 'R280K', 'R280S', 'R280T', 'D281A', 'D281G', 'D281V', 'D281Y', 'R282G', 'R282L', 'R282P', 'R282Q', 'R282W', 'R283P', 'T284I', 'T284P', 'T284R', 'E285A', 'E285D', 'E285G', 'E286A', 'E286D', 'E286G', 'E287A', 'E287G', 'L289P'] +- We aggregated all the variants that have at least one of the MAVISp modules with a predicted damaging effect (except for PTM.function) and retained only the ones with a popEVE score < -4.617 for a total of 261 variants which could be of interest for further investigation: +-- ['F109D', 'F109E', 'F109G', 'F109K', 'F109N', 'F109R', 'L130D', 'K132F', 'F134E', 'C135D', 'C135E', 'C135H', 'C135K', 'C135P', 'C135Q', 'Q136W', 'Q136Y', 'A138W', 'K139F', 'C141D', 'C141E', 'C141K', 'P142W', 'V143D', 'V143E', 'V143K', 'A161W', 'Y163E', 'V173D', 'V173K', 'V173W', 'V173Y', 'R175D', 'C176E', 'C176G', 'C176I', 'C176K', 'C176M', 'C176N', 'C176P', 'C176Q', 'C176T', 'C176V', 'C176W', 'P177W', 'H193E', 'H193G', 'H193I', 'H193M', 'H193V', 'H193W', 'L194D', 'L194E', 'L194G', 'L194K', 'L194N', 'I195W', 'E198W', 'G199F', 'G199I', 'G199W', 'T211W', 'V216D', 'V216K', 'V216R', 'V218K', 'V218W', 'Y220D', 'Y220E', 'Y220K', 'Y234D', 'Y234E', 'Y234K', 'Y234P', 'M237D', 'M237E', 'M237W', 'C238A', 'C238D', 'C238E', 'C238F', 'C238G', 'C238H', 'C238I', 'C238K', 'C238L', 'C238M', 'C238N', 'C238P', 'C238Q', 'C238R', 'C238T', 'C238W', 'C238Y', 'N239W', 'S240W', 'S240Y', 'C242A', 'C242D', 'C242E', 'C242F', 'C242G', 'C242H', 'C242I', 'C242K', 'C242L', 'C242M', 'C242N', 'C242P', 'C242Q', 'C242R', 'C242T', 'C242V', 'C242W', 'C242Y', 'G244I', 'G244W', 'G244Y', 'G245L', 'G245P', 'G245W', 'G245Y', 'M246D', 'R248A', 'R248D', 'R248E', 'R248I', 'R248M', 'R248N', 'R248T', 'R248V', 'R249A', 'R249D', 'R249F', 'R249I', 'R249P', 'R249V', 'R249Y', 'I251D', 'I251E', 'I251G', 'I251H', 'I251K', 'I251Q', 'I251R', 'I251W', 'I251Y', 'T253W', 'I254D', 'I254E', 'I254G', 'I254H', 'I254K', 'I254N', 'I254P', 'I254R', 'I254W', 'I254Y', 'I255D', 'I255E', 'I255K', 'I255P', 'I255R', 'L257D', 'L257E', 'L257G', 'L257K', 'L257N', 'L257R', 'L257W', 'L257Y', 'E258N', 'E258P', 'E258W', 'G262I', 'L265D', 'L265E', 'L265G', 'L265N', 'G266F', 'G266H', 'G266I', 'G266K', 'G266L', 'G266M', 'G266N', 'G266P', 'G266Q', 'G266T', 'G266V', 'G266W', 'G266Y', 'F270D', 'F270E', 'F270K', 'F270N', 'F270P', 'F270R', 'E271W', 'V272D', 'V272H', 'V272K', 'V272R', 'V272W', 'R273D', 'R273E', 'R273I', 'R273P', 'V274D', 'V274W', 'C275A', 'C275E', 'C275F', 'C275G', 'C275H', 'C275I', 'C275K', 'C275L', 'C275M', 'C275N', 'C275P', 'C275Q', 'C275R', 'C275T', 'C275V', 'C275W', 'C275Y', 'A276F', 'C277A', 'C277D', 'C277E', 'C277F', 'C277G', 'C277H', 'C277K', 'C277P', 'C277R', 'C277W', 'C277Y', 'P278D', 'P278N', 'P278W', 'G279Y', 'R280A', 'R280D', 'R280E', 'R280F', 'R280G', 'R280I', 'R280M', 'R280N', 'R280T', 'R280V', 'R280Y', 'D281I', 'D281K', 'D281P', 'D281R', 'D281V', 'D281Y', 'R282D'] +- We aggregated all the variants that have at least one of the MAVISp modules with a predicted damaging effect (except for PTM.function) and retained only the ones with a Demask delta fitness >= 0.25 or <= -0.25 for a total of 2111 variants which could be of interest for further investigation: +-- ['W91A', 'W91C', 'W91D', 'W91E', 'W91G', 'W91H', 'W91I', 'W91K', 'W91M', 'W91N', 'W91P', 'W91Q', 'W91R', 'W91T', 'P92F', 'P92R', 'P92W', 'P92Y', 'L93D', 'L93E', 'L93G', 'L93H', 'S94P', 'V97A', 'V97C', 'V97D', 'V97F', 'V97G', 'V97H', 'V97K', 'V97M', 'V97N', 'V97P', 'V97R', 'V97S', 'V97T', 'V97W', 'V97Y', 'P98A', 'P98E', 'P98F', 'P98G', 'P98H', 'P98I', 'P98K', 'P98L', 'P98M', 'P98Q', 'P98R', 'P98S', 'P98V', 'P98W', 'P98Y', 'S99D', 'S99H', 'S99K', 'S99L', 'S99M', 'S99P', 'S99R', 'S99W', 'S99Y', 'K101F', 'K101P', 'K101W', 'T102E', 'T102F', 'T102H', 'T102K', 'T102L', 'T102M', 'T102Q', 'T102R', 'T102V', 'T102W', 'T102Y', 'Y103A', 'Y103C', 'Y103D', 'Y103E', 'Y103G', 'Y103H', 'Y103I', 'Y103K', 'Y103L', 'Y103M', 'Y103N', 'Y103P', 'Y103Q', 'Y103R', 'Y103S', 'Y103T', 'Y103V', 'Y103W', 'G105A', 'G105C', 'G105D', 'G105E', 'G105F', 'G105H', 'G105I', 'G105K', 'G105L', 'G105M', 'G105N', 'G105P', 'G105Q', 'G105R', 'G105S', 'G105T', 'G105V', 'G105W', 'G105Y', 'Y107A', 'Y107D', 'Y107E', 'Y107G', 'Y107I', 'Y107K', 'Y107M', 'Y107N', 'Y107P', 'Y107Q', 'Y107R', 'Y107S', 'Y107T', 'Y107V', 'G108I', 'G108P', 'G108W', 'G108Y', 'F109A', 'F109C', 'F109D', 'F109E', 'F109G', 'F109H', 'F109I', 'F109K', 'F109N', 'F109P', 'F109Q', 'F109R', 'F109S', 'F109T', 'F109V', 'F109Y', 'R110P', 'L111A', 'L111C', 'L111D', 'L111E', 'L111F', 'L111G', 'L111H', 'L111K', 'L111N', 'L111P', 'L111Q', 'L111R', 'L111S', 'L111T', 'L111W', 'L111Y', 'G112F', 'G112K', 'G112P', 'G112W', 'G112Y', 'F113A', 'F113C', 'F113D', 'F113E', 'F113G', 'F113H', 'F113I', 'F113K', 'F113L', 'F113M', 'F113N', 'F113P', 'F113Q', 'F113R', 'F113S', 'F113T', 'F113V', 'F113W', 'L114A', 'L114C', 'L114D', 'L114E', 'L114G', 'L114H', 'L114N', 'L114P', 'L114R', 'L114S', 'L114W', 'L114Y', 'H115G', 'H115P', 'S116D', 'S116E', 'S116F', 'S116G', 'S116H', 'S116I', 'S116K', 'S116L', 'S116M', 'S116P', 'S116Q', 'S116R', 'S116V', 'S116W', 'S116Y', 'G117A', 'G117C', 'G117D', 'G117E', 'G117F', 'G117H', 'G117I', 'G117K', 'G117L', 'G117M', 'G117N', 'G117P', 'G117Q', 'G117R', 'G117T', 'G117V', 'G117W', 'G117Y', 'T118C', 'T118G', 'A119G', 'K120A', 'K120C', 'K120D', 'K120E', 'K120G', 'K120H', 'K120M', 'K120N', 'K120P', 'K120Q', 'K120S', 'K120T', 'K120V', 'S121F', 'V122C', 'V122D', 'V122F', 'V122G', 'V122H', 'V122K', 'V122M', 'V122N', 'V122P', 'V122R', 'V122S', 'V122T', 'V122W', 'V122Y', 'T123A', 'T123C', 'T123E', 'T123F', 'T123G', 'T123H', 'T123K', 'T123L', 'T123M', 'T123Q', 'T123R', 'T123S', 'T123W', 'T123Y', 'C124A', 'C124D', 'C124E', 'C124F', 'C124G', 'C124H', 'C124I', 'C124K', 'C124L', 'C124M', 'C124N', 'C124P', 'C124Q', 'C124R', 'C124S', 'C124T', 'C124V', 'C124Y', 'T125A', 'T125C', 'T125D', 'T125E', 'T125F', 'T125G', 'T125H', 'T125I', 'T125K', 'T125M', 'T125N', 'T125P', 'T125Q', 'T125R', 'T125S', 'T125W', 'T125Y', 'Y126A', 'Y126C', 'Y126D', 'Y126E', 'Y126G', 'Y126H', 'Y126I', 'Y126K', 'Y126L', 'Y126M', 'Y126N', 'Y126P', 'Y126Q', 'Y126R', 'Y126S', 'Y126T', 'Y126V', 'Y126W', 'S127C', 'S127D', 'S127E', 'S127F', 'S127G', 'S127H', 'S127I', 'S127K', 'S127L', 'S127M', 'S127N', 'S127P', 'S127Q', 'S127R', 'S127T', 'S127V', 'S127W', 'S127Y', 'L130A', 'L130C', 'L130D', 'L130E', 'L130F', 'L130G', 'L130H', 'L130K', 'L130N', 'L130P', 'L130Q', 'L130R', 'L130S', 'L130T', 'L130V', 'L130W', 'L130Y', 'N131C', 'N131E', 'N131F', 'N131G', 'N131L', 'N131P', 'N131R', 'N131V', 'N131W', 'N131Y', 'K132D', 'K132E', 'K132F', 'K132G', 'K132P', 'K132W', 'K132Y', 'M133A', 'M133C', 'M133D', 'M133E', 'M133F', 'M133G', 'M133H', 'M133K', 'M133N', 'M133P', 'M133Q', 'M133R', 'M133S', 'M133T', 'M133W', 'M133Y', 'F134A', 'F134C', 'F134D', 'F134E', 'F134G', 'F134H', 'F134I', 'F134K', 'F134L', 'F134M', 'F134N', 'F134P', 'F134Q', 'F134R', 'F134S', 'F134T', 'F134V', 'C135A', 'C135D', 'C135E', 'C135F', 'C135G', 'C135H', 'C135I', 'C135K', 'C135L', 'C135M', 'C135N', 'C135P', 'C135Q', 'C135R', 'C135S', 'C135T', 'C135V', 'C135W', 'C135Y', 'Q136A', 'Q136C', 'Q136D', 'Q136E', 'Q136F', 'Q136G', 'Q136H', 'Q136I', 'Q136K', 'Q136L', 'Q136M', 'Q136N', 'Q136P', 'Q136S', 'Q136T', 'Q136W', 'Q136Y', 'L137A', 'L137C', 'L137D', 'L137E', 'L137G', 'L137H', 'L137N', 'L137P', 'L137Q', 'L137R', 'L137S', 'L137T', 'L137W', 'L137Y', 'A138C', 'A138D', 'A138E', 'A138F', 'A138H', 'A138I', 'A138K', 'A138L', 'A138M', 'A138N', 'A138P', 'A138Q', 'A138R', 'A138T', 'A138V', 'A138W', 'A138Y', 'K139A', 'K139C', 'K139D', 'K139E', 'K139F', 'K139G', 'K139H', 'K139M', 'K139N', 'K139P', 'K139S', 'K139T', 'K139V', 'K139W', 'K139Y', 'T140C', 'T140E', 'T140F', 'T140G', 'T140H', 'T140I', 'T140K', 'T140L', 'T140M', 'T140Q', 'T140R', 'T140V', 'T140W', 'T140Y', 'C141A', 'C141D', 'C141E', 'C141F', 'C141G', 'C141H', 'C141I', 'C141K', 'C141L', 'C141M', 'C141N', 'C141P', 'C141Q', 'C141R', 'C141S', 'C141T', 'C141V', 'C141W', 'C141Y', 'P142A', 'P142D', 'P142E', 'P142F', 'P142G', 'P142H', 'P142I', 'P142K', 'P142L', 'P142M', 'P142N', 'P142Q', 'P142R', 'P142S', 'P142V', 'P142W', 'P142Y', 'V143A', 'V143C', 'V143D', 'V143E', 'V143F', 'V143G', 'V143H', 'V143K', 'V143N', 'V143P', 'V143Q', 'V143R', 'V143S', 'V143T', 'V143W', 'V143Y', 'Q144C', 'Q144F', 'Q144I', 'Q144P', 'Q144W', 'L145A', 'L145C', 'L145D', 'L145E', 'L145G', 'L145H', 'L145K', 'L145N', 'L145P', 'L145Q', 'L145R', 'L145S', 'L145W', 'L145Y', 'W146A', 'W146C', 'W146D', 'W146E', 'W146G', 'W146H', 'W146I', 'W146K', 'W146L', 'W146M', 'W146N', 'W146P', 'W146Q', 'W146R', 'W146S', 'W146T', 'W146V', 'V147D', 'V147E', 'V147F', 'V147G', 'V147H', 'V147K', 'V147N', 'V147P', 'V147Q', 'V147R', 'V147S', 'V147W', 'V147Y', 'P151A', 'P151D', 'P151E', 'P151F', 'P151G', 'P151H', 'P151I', 'P151K', 'P151L', 'P151M', 'P151N', 'P151Q', 'P151R', 'P151W', 'P151Y', 'P152A', 'P152G', 'P152S', 'G154A', 'G154C', 'G154D', 'G154E', 'G154F', 'G154H', 'G154I', 'G154K', 'G154L', 'G154M', 'G154N', 'G154P', 'G154Q', 'G154R', 'G154S', 'G154T', 'G154V', 'G154W', 'G154Y', 'T155D', 'T155E', 'T155F', 'T155H', 'T155K', 'T155L', 'T155P', 'T155Q', 'T155R', 'T155W', 'T155Y', 'R156D', 'R156E', 'R156G', 'R156N', 'R156P', 'R156W', 'R156Y', 'V157D', 'V157E', 'V157G', 'V157H', 'V157K', 'V157N', 'V157P', 'V157Q', 'V157R', 'V157S', 'V157W', 'V157Y', 'R158A', 'R158C', 'R158D', 'R158E', 'R158F', 'R158G', 'R158H', 'R158I', 'R158L', 'R158M', 'R158N', 'R158P', 'R158Q', 'R158S', 'R158T', 'R158V', 'R158W', 'R158Y', 'A159C', 'A159D', 'A159E', 'A159F', 'A159H', 'A159I', 'A159K', 'A159L', 'A159M', 'A159N', 'A159P', 'A159Q', 'A159R', 'A159W', 'A159Y', 'M160A', 'M160C', 'M160D', 'M160E', 'M160F', 'M160G', 'M160H', 'M160K', 'M160N', 'M160P', 'M160Q', 'M160R', 'M160S', 'M160W', 'M160Y', 'A161D', 'A161E', 'A161F', 'A161H', 'A161K', 'A161R', 'A161W', 'A161Y', 'I162D', 'I162E', 'I162F', 'I162G', 'I162H', 'I162K', 'I162N', 'I162P', 'I162Q', 'I162R', 'I162S', 'I162W', 'I162Y', 'Y163A', 'Y163C', 'Y163D', 'Y163E', 'Y163G', 'Y163H', 'Y163I', 'Y163K', 'Y163L', 'Y163M', 'Y163N', 'Y163P', 'Y163Q', 'Y163R', 'Y163S', 'Y163T', 'Y163V', 'Y163W', 'K164A', 'K164C', 'K164D', 'K164E', 'K164G', 'K164H', 'K164M', 'K164N', 'K164P', 'K164Q', 'K164S', 'K164T', 'K164V', 'Q165A', 'Q165C', 'Q165D', 'Q165G', 'Q165P', 'Q165T', 'Q167C', 'Q167F', 'Q167I', 'Q167K', 'Q167P', 'Q167T', 'Q167W', 'Q167Y', 'H168A', 'H168C', 'H168E', 'H168G', 'H168I', 'H168K', 'H168L', 'H168M', 'H168N', 'H168P', 'H168R', 'H168S', 'H168T', 'H168V', 'H168W', 'M169C', 'M169D', 'M169E', 'M169G', 'M169H', 'M169N', 'M169P', 'M169Q', 'M169S', 'M169T', 'M169Y', 'T170C', 'T170E', 'T170F', 'T170H', 'T170I', 'T170L', 'T170Q', 'T170R', 'T170W', 'T170Y', 'E171A', 'E171C', 'E171G', 'E171N', 'E171P', 'E171S', 'E171T', 'V172A', 'V172C', 'V172D', 'V172E', 'V172F', 'V172G', 'V172H', 'V172K', 'V172N', 'V172P', 'V172R', 'V172S', 'V172T', 'V172W', 'V172Y', 'V173A', 'V173C', 'V173D', 'V173E', 'V173F', 'V173G', 'V173H', 'V173K', 'V173M', 'V173N', 'V173P', 'V173Q', 'V173R', 'V173S', 'V173T', 'V173W', 'V173Y', 'R174A', 'R174C', 'R174D', 'R174E', 'R174F', 'R174G', 'R174H', 'R174I', 'R174M', 'R174N', 'R174P', 'R174T', 'R174V', 'R174W', 'R174Y', 'R175A', 'R175C', 'R175D', 'R175E', 'R175F', 'R175G', 'R175H', 'R175I', 'R175L', 'R175M', 'R175N', 'R175P', 'R175Q', 'R175S', 'R175T', 'R175V', 'R175W', 'R175Y', 'C176A', 'C176E', 'C176F', 'C176G', 'C176H', 'C176I', 'C176K', 'C176L', 'C176M', 'C176N', 'C176P', 'C176Q', 'C176R', 'C176S', 'C176T', 'C176V', 'C176W', 'C176Y', 'P177E', 'P177F', 'P177H', 'P177I', 'P177K', 'P177L', 'P177M', 'P177Q', 'P177R', 'P177V', 'P177W', 'P177Y', 'H178C', 'H178E', 'H178G', 'H178I', 'H178L', 'H178P', 'H179A', 'H179C', 'H179D', 'H179E', 'H179F', 'H179G', 'H179I', 'H179K', 'H179L', 'H179M', 'H179N', 'H179P', 'H179R', 'H179S', 'H179T', 'H179V', 'H179W', 'H179Y', 'E180A', 'E180C', 'E180F', 'E180G', 'E180H', 'E180I', 'E180K', 'E180L', 'E180M', 'E180N', 'E180P', 'E180R', 'E180S', 'E180T', 'E180W', 'E180Y', 'R181A', 'R181D', 'R181E', 'R181F', 'R181G', 'R181H', 'R181I', 'R181M', 'R181P', 'R181V', 'R181W', 'R181Y', 'C182H', 'C182K', 'C182L', 'C182M', 'C182P', 'C182Q', 'C182W', 'D184F', 'D184I', 'D184K', 'D184L', 'D184W', 'D186F', 'D186I', 'D186K', 'D186L', 'D186R', 'D186V', 'D186W', 'G187F', 'G187H', 'G187I', 'G187K', 'G187L', 'G187P', 'G187R', 'G187W', 'G187Y', 'L188D', 'L188E', 'A189D', 'A189F', 'A189G', 'A189H', 'A189K', 'A189P', 'A189Q', 'A189R', 'A189W', 'A189Y', 'P190E', 'P190F', 'P190G', 'P190I', 'P190K', 'P190L', 'P190M', 'P190R', 'P190T', 'P190V', 'P190W', 'P190Y', 'P191F', 'P191I', 'P191L', 'P191W', 'P191Y', 'Q192P', 'H193A', 'H193C', 'H193D', 'H193E', 'H193F', 'H193G', 'H193I', 'H193K', 'H193L', 'H193M', 'H193N', 'H193P', 'H193Q', 'H193R', 'H193S', 'H193T', 'H193V', 'H193W', 'H193Y', 'L194A', 'L194C', 'L194D', 'L194E', 'L194G', 'L194H', 'L194K', 'L194N', 'L194P', 'L194Q', 'L194R', 'L194S', 'L194T', 'L194V', 'L194W', 'L194Y', 'I195A', 'I195C', 'I195D', 'I195E', 'I195F', 'I195G', 'I195H', 'I195K', 'I195N', 'I195P', 'I195Q', 'I195R', 'I195S', 'I195T', 'I195W', 'I195Y', 'R196A', 'R196C', 'R196D', 'R196E', 'R196F', 'R196G', 'R196H', 'R196I', 'R196L', 'R196M', 'R196N', 'R196P', 'R196Q', 'R196S', 'R196T', 'R196V', 'R196W', 'R196Y', 'V197A', 'V197C', 'V197D', 'V197E', 'V197F', 'V197G', 'V197H', 'V197K', 'V197N', 'V197P', 'V197Q', 'V197R', 'V197S', 'V197T', 'V197W', 'V197Y', 'E198A', 'E198C', 'E198D', 'E198F', 'E198G', 'E198H', 'E198I', 'E198K', 'E198L', 'E198M', 'E198N', 'E198P', 'E198Q', 'E198R', 'E198S', 'E198T', 'E198W', 'E198Y', 'G199A', 'G199C', 'G199D', 'G199E', 'G199F', 'G199H', 'G199I', 'G199K', 'G199L', 'G199M', 'G199N', 'G199P', 'G199Q', 'G199R', 'G199S', 'G199T', 'G199V', 'G199W', 'G199Y', 'N200A', 'N200C', 'N200E', 'N200F', 'N200H', 'N200K', 'N200L', 'N200M', 'N200P', 'N200Q', 'N200R', 'N200V', 'N200W', 'N200Y', 'L201D', 'L201G', 'R202D', 'R202E', 'R202F', 'R202I', 'R202P', 'V203D', 'V203E', 'V203F', 'V203G', 'V203H', 'V203K', 'V203M', 'V203N', 'V203P', 'V203Q', 'V203R', 'V203S', 'V203T', 'V203W', 'V203Y', 'E204P', 'Y205A', 'Y205C', 'Y205D', 'Y205E', 'Y205G', 'Y205H', 'Y205I', 'Y205K', 'Y205L', 'Y205M', 'Y205N', 'Y205P', 'Y205Q', 'Y205R', 'Y205S', 'Y205T', 'Y205V', 'Y205W', 'L206D', 'L206G', 'L206N', 'D207F', 'D207I', 'D207K', 'D207L', 'D207R', 'D207W', 'D207Y', 'D208A', 'D208E', 'D208F', 'D208G', 'D208H', 'D208I', 'D208K', 'D208L', 'D208M', 'D208P', 'D208Q', 'D208R', 'D208S', 'D208V', 'D208W', 'D208Y', 'N210P', 'T211C', 'T211D', 'T211E', 'T211F', 'T211G', 'T211H', 'T211I', 'T211K', 'T211L', 'T211M', 'T211N', 'T211P', 'T211Q', 'T211R', 'T211V', 'T211W', 'T211Y', 'F212P', 'R213A', 'R213C', 'R213D', 'R213E', 'R213F', 'R213G', 'R213H', 'R213I', 'R213L', 'R213M', 'R213N', 'R213P', 'R213Q', 'R213S', 'R213T', 'R213V', 'R213W', 'R213Y', 'H214I', 'H214L', 'H214W', 'S215A', 'S215C', 'S215D', 'S215G', 'S215I', 'S215K', 'S215L', 'S215P', 'S215T', 'S215V', 'V216A', 'V216C', 'V216D', 'V216E', 'V216F', 'V216G', 'V216H', 'V216K', 'V216M', 'V216N', 'V216P', 'V216Q', 'V216R', 'V216S', 'V216T', 'V216W', 'V216Y', 'V217D', 'V217E', 'V217H', 'V217K', 'V217N', 'V217P', 'V217Q', 'V217R', 'V218A', 'V218C', 'V218D', 'V218E', 'V218F', 'V218G', 'V218H', 'V218K', 'V218N', 'V218P', 'V218Q', 'V218R', 'V218S', 'V218T', 'V218W', 'V218Y', 'P219A', 'P219G', 'Y220A', 'Y220C', 'Y220D', 'Y220E', 'Y220G', 'Y220H', 'Y220I', 'Y220K', 'Y220L', 'Y220M', 'Y220N', 'Y220P', 'Y220Q', 'Y220R', 'Y220S', 'Y220T', 'Y220V', 'Y220W', 'E221C', 'E221F', 'E221G', 'E221H', 'E221I', 'E221K', 'E221L', 'E221M', 'E221N', 'E221P', 'E221R', 'E221T', 'E221W', 'E221Y', 'P222F', 'P222W', 'P223D', 'P223F', 'P223G', 'P223H', 'P223I', 'P223K', 'P223L', 'P223N', 'P223R', 'P223V', 'P223W', 'P223Y', 'E224C', 'E224F', 'E224G', 'E224H', 'E224I', 'E224K', 'E224N', 'E224P', 'E224R', 'E224S', 'E224T', 'E224W', 'E224Y', 'V225C', 'V225D', 'V225F', 'V225G', 'V225H', 'V225K', 'V225M', 'V225N', 'V225P', 'V225R', 'V225S', 'V225T', 'V225W', 'V225Y', 'G226A', 'G226C', 'G226D', 'G226E', 'G226F', 'G226H', 'G226I', 'G226K', 'G226L', 'G226M', 'G226N', 'G226P', 'G226Q', 'G226R', 'G226S', 'G226T', 'G226V', 'G226W', 'G226Y', 'D228F', 'D228H', 'D228I', 'D228K', 'D228L', 'D228M', 'D228R', 'D228S', 'D228W', 'D228Y', 'C229P', 'T230C', 'T230D', 'T230E', 'T230G', 'T230P', 'T231A', 'T231C', 'T231E', 'T231F', 'T231G', 'T231H', 'T231I', 'T231K', 'T231L', 'T231M', 'T231Q', 'T231R', 'T231V', 'T231W', 'T231Y', 'I232A', 'I232C', 'I232D', 'I232E', 'I232G', 'I232H', 'I232K', 'I232N', 'I232P', 'I232Q', 'I232R', 'I232S', 'I232W', 'I232Y', 'H233C', 'H233D', 'H233E', 'H233G', 'H233I', 'H233K', 'H233P', 'H233R', 'H233T', 'H233V', 'H233W', 'Y234A', 'Y234C', 'Y234D', 'Y234E', 'Y234G', 'Y234H', 'Y234I', 'Y234K', 'Y234L', 'Y234M', 'Y234N', 'Y234P', 'Y234Q', 'Y234R', 'Y234S', 'Y234T', 'Y234V', 'Y234W', 'N235A', 'N235C', 'N235E', 'N235F', 'N235G', 'N235H', 'N235I', 'N235L', 'N235M', 'N235P', 'N235Q', 'N235V', 'N235W', 'N235Y', 'Y236A', 'Y236C', 'Y236D', 'Y236E', 'Y236G', 'Y236H', 'Y236I', 'Y236K', 'Y236L', 'Y236M', 'Y236N', 'Y236P', 'Y236Q', 'Y236R', 'Y236S', 'Y236T', 'Y236V', 'Y236W', 'M237A', 'M237C', 'M237D', 'M237E', 'M237F', 'M237G', 'M237H', 'M237K', 'M237N', 'M237P', 'M237Q', 'M237R', 'M237S', 'M237T', 'M237V', 'M237W', 'M237Y', 'C238A', 'C238D', 'C238E', 'C238F', 'C238G', 'C238H', 'C238I', 'C238K', 'C238L', 'C238M', 'C238N', 'C238P', 'C238Q', 'C238R', 'C238S', 'C238T', 'C238V', 'C238W', 'C238Y', 'N239E', 'N239F', 'N239H', 'N239I', 'N239K', 'N239L', 'N239M', 'N239Q', 'N239R', 'N239V', 'N239W', 'N239Y', 'S240F', 'S240G', 'S240P', 'S240W', 'S240Y', 'S241D', 'S241P', 'S241V', 'C242A', 'C242D', 'C242E', 'C242F', 'C242G', 'C242H', 'C242I', 'C242K', 'C242L', 'C242M', 'C242N', 'C242P', 'C242Q', 'C242R', 'C242S', 'C242T', 'C242V', 'C242W', 'C242Y', 'M243A', 'M243C', 'M243D', 'M243E', 'M243F', 'M243G', 'M243H', 'M243K', 'M243N', 'M243P', 'M243Q', 'M243R', 'M243S', 'M243T', 'M243W', 'M243Y', 'G244A', 'G244C', 'G244D', 'G244E', 'G244F', 'G244H', 'G244I', 'G244K', 'G244L', 'G244M', 'G244N', 'G244P', 'G244Q', 'G244R', 'G244S', 'G244T', 'G244V', 'G244W', 'G244Y', 'G245A', 'G245C', 'G245D', 'G245E', 'G245F', 'G245H', 'G245I', 'G245K', 'G245L', 'G245M', 'G245N', 'G245P', 'G245Q', 'G245R', 'G245S', 'G245T', 'G245V', 'G245W', 'G245Y', 'M246A', 'M246C', 'M246D', 'M246E', 'M246F', 'M246G', 'M246H', 'M246K', 'M246N', 'M246P', 'M246Q', 'M246R', 'M246S', 'M246T', 'M246V', 'M246W', 'M246Y', 'N247D', 'N247I', 'N247P', 'N247T', 'N247V', 'R248A', 'R248C', 'R248D', 'R248E', 'R248G', 'R248H', 'R248I', 'R248L', 'R248M', 'R248N', 'R248P', 'R248Q', 'R248S', 'R248T', 'R248V', 'R249A', 'R249C', 'R249D', 'R249E', 'R249F', 'R249G', 'R249H', 'R249I', 'R249L', 'R249M', 'R249N', 'R249P', 'R249Q', 'R249S', 'R249T', 'R249V', 'R249W', 'R249Y', 'P250G', 'P250S', 'I251A', 'I251C', 'I251D', 'I251E', 'I251F', 'I251G', 'I251H', 'I251K', 'I251N', 'I251P', 'I251Q', 'I251R', 'I251S', 'I251T', 'I251W', 'I251Y', 'L252D', 'L252G', 'L252H', 'L252P', 'L252S', 'T253D', 'T253E', 'T253F', 'T253G', 'T253H', 'T253K', 'T253P', 'T253R', 'T253W', 'T253Y', 'I254A', 'I254D', 'I254E', 'I254G', 'I254H', 'I254K', 'I254N', 'I254P', 'I254Q', 'I254R', 'I254S', 'I254T', 'I254W', 'I254Y', 'I255A', 'I255C', 'I255D', 'I255E', 'I255F', 'I255G', 'I255H', 'I255K', 'I255N', 'I255P', 'I255Q', 'I255R', 'I255S', 'I255W', 'I255Y', 'T256G', 'T256P', 'L257A', 'L257C', 'L257D', 'L257E', 'L257F', 'L257G', 'L257H', 'L257K', 'L257N', 'L257P', 'L257Q', 'L257R', 'L257S', 'L257T', 'L257W', 'L257Y', 'E258D', 'E258G', 'E258K', 'E258N', 'E258P', 'E258R', 'E258W', 'D259C', 'D259F', 'D259I', 'D259K', 'D259L', 'D259P', 'D259Q', 'D259R', 'D259V', 'D259W', 'S261P', 'G262A', 'G262C', 'G262D', 'G262E', 'G262F', 'G262H', 'G262I', 'G262K', 'G262L', 'G262M', 'G262N', 'G262P', 'G262Q', 'G262R', 'G262S', 'G262T', 'G262V', 'G262W', 'G262Y', 'N263P', 'L264F', 'L264G', 'L264R', 'L264W', 'L264Y', 'L265A', 'L265D', 'L265E', 'L265G', 'L265H', 'L265K', 'L265N', 'L265P', 'L265Q', 'L265R', 'L265S', 'L265T', 'L265W', 'G266C', 'G266D', 'G266E', 'G266F', 'G266H', 'G266I', 'G266K', 'G266L', 'G266M', 'G266N', 'G266P', 'G266Q', 'G266R', 'G266S', 'G266T', 'G266V', 'G266W', 'G266Y', 'R267A', 'R267C', 'R267D', 'R267E', 'R267F', 'R267G', 'R267H', 'R267I', 'R267L', 'R267M', 'R267N', 'R267P', 'R267Q', 'R267S', 'R267T', 'R267V', 'R267W', 'R267Y', 'N268P', 'S269D', 'S269E', 'S269F', 'S269H', 'S269I', 'S269K', 'S269L', 'S269P', 'S269R', 'S269W', 'S269Y', 'F270A', 'F270C', 'F270D', 'F270E', 'F270G', 'F270H', 'F270I', 'F270K', 'F270L', 'F270M', 'F270N', 'F270P', 'F270Q', 'F270R', 'F270S', 'F270T', 'F270V', 'F270W', 'E271W', 'V272D', 'V272E', 'V272F', 'V272H', 'V272K', 'V272N', 'V272P', 'V272Q', 'V272R', 'V272S', 'V272W', 'V272Y', 'R273A', 'R273C', 'R273D', 'R273E', 'R273G', 'R273H', 'R273I', 'R273L', 'R273M', 'R273N', 'R273P', 'R273Q', 'R273S', 'R273T', 'R273V', 'R273W', 'V274A', 'V274D', 'V274E', 'V274F', 'V274G', 'V274H', 'V274K', 'V274N', 'V274P', 'V274Q', 'V274R', 'V274S', 'V274T', 'V274W', 'V274Y', 'C275A', 'C275E', 'C275F', 'C275G', 'C275H', 'C275I', 'C275K', 'C275L', 'C275M', 'C275N', 'C275P', 'C275Q', 'C275R', 'C275S', 'C275T', 'C275V', 'C275W', 'C275Y', 'A276C', 'A276F', 'A276G', 'A276K', 'A276M', 'A276P', 'C277A', 'C277D', 'C277E', 'C277F', 'C277G', 'C277H', 'C277K', 'C277P', 'C277R', 'C277S', 'C277W', 'C277Y', 'P278A', 'P278C', 'P278D', 'P278E', 'P278F', 'P278G', 'P278H', 'P278I', 'P278K', 'P278L', 'P278M', 'P278N', 'P278Q', 'P278R', 'P278S', 'P278T', 'P278V', 'P278W', 'P278Y', 'G279A', 'G279C', 'G279D', 'G279E', 'G279F', 'G279H', 'G279I', 'G279K', 'G279L', 'G279M', 'G279N', 'G279P', 'G279Q', 'G279R', 'G279S', 'G279T', 'G279V', 'G279W', 'G279Y', 'R280A', 'R280C', 'R280D', 'R280E', 'R280F', 'R280G', 'R280H', 'R280I', 'R280K', 'R280L', 'R280M', 'R280N', 'R280P', 'R280Q', 'R280S', 'R280T', 'R280V', 'R280W', 'R280Y', 'D281A', 'D281C', 'D281G', 'D281I', 'D281K', 'D281P', 'D281R', 'D281S', 'D281T', 'D281V', 'D281Y', 'R282A', 'R282C', 'R282D', 'R282E', 'R282G', 'R282H', 'R282I', 'R282L', 'R282M', 'R282N', 'R282P', 'R282Q', 'R282S', 'R282T', 'R282V', 'R282W', 'R283P', 'T284D', 'T284E', 'T284F', 'T284G', 'T284K', 'T284P', 'T284R', 'T284W', 'E285C', 'E285G', 'E285N', 'E285P', 'E285T', 'E286A', 'E286C', 'E286G', 'E286N', 'E286P', 'E286S', 'E286T', 'E287P', 'N288P', 'L289D'] +- We aggregated all the variants that have at least one of the MAVISp modules with a predicted damaging effect (except for PTM.function) and retained only the ones with an EVE classification of Pathogenic for a total of 1297 variants which could be of interest for further investigation: + -- ['S94W', 'S95H', 'S95K', 'S95W', 'V97C', 'V97D', 'V97H', 'V97K', 'V97R', 'V97T', 'V97W', 'P98A', 'P98E', 'P98F', 'P98G', 'P98K', 'P98M', 'P98R', 'P98W', 'P98Y', 'S99H', 'S99Q', 'S99W', 'S99Y', 'Y103A', 'Y103E', 'Y103G', 'Y103K', 'Y103P', 'Y103Q', 'Y103R', 'Y103T', 'G105A', 'G105E', 'G105F', 'G105H', 'G105I', 'G105K', 'G105L', 'G105M', 'G105P', 'G105Q', 'G105R', 'G105T', 'G105V', 'G105W', 'G105Y', 'Y107E', 'Y107G', 'Y107K', 'Y107T', 'F109A', 'F109C', 'F109D', 'F109E', 'F109G', 'F109H', 'F109I', 'F109K', 'F109N', 'F109P', 'F109Q', 'F109R', 'F109S', 'F109T', 'F109V', 'F109Y', 'L111A', 'L111D', 'L111E', 'L111G', 'L111H', 'L111K', 'L111N', 'L111P', 'L111Q', 'L111R', 'L111S', 'L111T', 'L111W', 'F113A', 'F113D', 'F113E', 'F113G', 'F113H', 'F113K', 'F113N', 'F113P', 'F113Q', 'F113R', 'F113S', 'F113T', 'S116H', 'S116I', 'S116M', 'S116R', 'S116W', 'S116Y', 'G117C', 'G117F', 'G117H', 'G117I', 'G117L', 'G117M', 'G117T', 'G117W', 'G117Y', 'K120A', 'K120C', 'K120D', 'K120E', 'K120G', 'K120H', 'K120M', 'K120N', 'K120P', 'K120Q', 'K120T', 'K120V', 'S121F', 'V122C', 'V122D', 'V122F', 'V122G', 'V122H', 'V122K', 'V122W', 'V122Y', 'T123C', 'T123E', 'T123F', 'T123K', 'T123L', 'T123R', 'T123W', 'T123Y', 'C124A', 'C124D', 'C124E', 'C124G', 'C124I', 'C124K', 'C124M', 'C124P', 'C124Q', 'C124R', 'T125C', 'T125D', 'T125F', 'T125H', 'T125N', 'T125P', 'T125R', 'T125W', 'T125Y', 'Y126A', 'Y126C', 'Y126D', 'Y126E', 'Y126G', 'Y126I', 'Y126K', 'Y126L', 'Y126N', 'Y126P', 'Y126Q', 'Y126R', 'Y126S', 'Y126T', 'Y126V', 'S127C', 'S127E', 'S127F', 'S127G', 'S127H', 'S127I', 'S127K', 'S127L', 'S127M', 'S127P', 'S127Q', 'S127R', 'S127T', 'S127W', 'S127Y', 'P128M', 'P128W', 'L130A', 'L130D', 'L130E', 'L130F', 'L130G', 'L130H', 'L130N', 'L130P', 'L130S', 'L130W', 'L130Y', 'N131A', 'N131C', 'N131F', 'N131I', 'N131L', 'N131M', 'N131P', 'N131V', 'N131W', 'N131Y', 'K132D', 'K132E', 'K132F', 'K132G', 'K132P', 'K132W', 'K132Y', 'F134A', 'F134C', 'F134D', 'F134E', 'F134G', 'F134H', 'F134I', 'F134K', 'F134L', 'F134M', 'F134N', 'F134P', 'F134Q', 'F134R', 'F134S', 'F134T', 'F134V', 'C135D', 'C135E', 'C135F', 'C135G', 'C135H', 'C135K', 'C135L', 'C135M', 'C135N', 'C135P', 'C135Q', 'C135R', 'C135S', 'C135W', 'C135Y', 'Q136A', 'Q136C', 'Q136F', 'Q136G', 'Q136H', 'Q136I', 'Q136P', 'Q136S', 'Q136T', 'Q136W', 'Q136Y', 'L137C', 'L137D', 'L137E', 'L137G', 'L137H', 'L137N', 'L137W', 'L137Y', 'A138H', 'A138I', 'A138L', 'A138P', 'A138W', 'A138Y', 'K139D', 'K139F', 'K139G', 'K139M', 'K139P', 'K139W', 'K139Y', 'T140C', 'T140E', 'T140G', 'T140W', 'T140Y', 'C141A', 'C141D', 'C141E', 'C141G', 'C141H', 'C141K', 'C141M', 'C141P', 'C141Q', 'C141R', 'C141W', 'C141Y', 'P142A', 'P142D', 'P142E', 'P142F', 'P142G', 'P142I', 'P142N', 'P142Q', 'P142V', 'P142W', 'P142Y', 'V143C', 'V143D', 'V143E', 'V143G', 'V143H', 'V143K', 'V143N', 'V143P', 'V143Q', 'V143R', 'V143S', 'V143T', 'V143W', 'V143Y', 'Q144C', 'Q144F', 'Q144I', 'Q144P', 'Q144W', 'L145E', 'L145G', 'L145Q', 'L145W', 'V147D', 'V147E', 'V147G', 'V147H', 'V147K', 'V147N', 'V147P', 'V147Q', 'V147R', 'P151G', 'P151H', 'P151N', 'P151R', 'P151W', 'P152G', 'G154C', 'G154I', 'G154M', 'G154Y', 'T155W', 'V157A', 'V157D', 'V157E', 'V157F', 'V157G', 'V157H', 'V157K', 'V157N', 'V157P', 'V157Q', 'V157R', 'V157S', 'V157T', 'V157W', 'V157Y', 'R158A', 'R158D', 'R158E', 'R158F', 'R158G', 'R158I', 'R158M', 'R158N', 'R158P', 'R158Q', 'R158T', 'R158W', 'R158Y', 'A159D', 'A159E', 'A159F', 'A159K', 'A159M', 'A159N', 'A159P', 'A159Q', 'A159R', 'A159W', 'A159Y', 'M160C', 'M160D', 'M160F', 'M160H', 'M160N', 'M160P', 'M160R', 'M160W', 'A161D', 'A161E', 'A161F', 'A161H', 'A161K', 'A161R', 'A161W', 'A161Y', 'I162D', 'I162E', 'I162H', 'I162N', 'I162P', 'I162R', 'I162W', 'I162Y', 'Y163A', 'Y163D', 'Y163E', 'Y163G', 'Y163H', 'Y163I', 'Y163K', 'Y163L', 'Y163M', 'Y163N', 'Y163P', 'Y163Q', 'Y163R', 'Y163S', 'Y163T', 'Y163V', 'Y163W', 'K164D', 'K164G', 'K164H', 'K164N', 'K164P', 'S166K', 'S166W', 'H168C', 'H168E', 'H168G', 'H168I', 'H168K', 'H168L', 'H168M', 'H168P', 'H168R', 'H168T', 'H168V', 'H168W', 'M169C', 'M169D', 'T170W', 'E171A', 'E171C', 'E171G', 'E171P', 'V172C', 'V172D', 'V172E', 'V172F', 'V172G', 'V172K', 'V172R', 'V172W', 'V172Y', 'V173C', 'V173D', 'V173E', 'V173F', 'V173G', 'V173H', 'V173K', 'V173M', 'V173N', 'V173P', 'V173Q', 'V173R', 'V173S', 'V173T', 'V173W', 'V173Y', 'R174W', 'R175A', 'R175D', 'R175F', 'R175G', 'R175L', 'R175N', 'R175W', 'R175Y', 'C176A', 'C176E', 'C176F', 'C176G', 'C176I', 'C176K', 'C176L', 'C176M', 'C176N', 'C176P', 'C176Q', 'C176R', 'C176S', 'C176T', 'C176V', 'C176W', 'C176Y', 'P177E', 'P177F', 'P177I', 'P177K', 'P177M', 'P177Q', 'P177R', 'P177W', 'P177Y', 'H178C', 'H178D', 'H178E', 'H178F', 'H178G', 'H178K', 'H178M', 'H178P', 'H178R', 'H178W', 'H179A', 'H179C', 'H179D', 'H179E', 'H179F', 'H179G', 'H179I', 'H179K', 'H179M', 'H179P', 'H179Q', 'H179R', 'H179S', 'H179T', 'H179V', 'H179W', 'H179Y', 'E180C', 'E180D', 'E180F', 'E180G', 'E180H', 'E180N', 'E180P', 'E180W', 'E180Y', 'R181P', 'D186F', 'D186G', 'D186I', 'D186M', 'D186V', 'D186W', 'D186Y', 'A189R', 'A189W', 'P190G', 'P190M', 'P190W', 'P191F', 'P191W', 'P191Y', 'Q192W', 'H193A', 'H193C', 'H193D', 'H193E', 'H193F', 'H193G', 'H193I', 'H193K', 'H193L', 'H193M', 'H193N', 'H193P', 'H193R', 'H193S', 'H193T', 'H193V', 'H193W', 'L194A', 'L194C', 'L194D', 'L194E', 'L194G', 'L194H', 'L194K', 'L194N', 'L194P', 'L194Q', 'L194R', 'L194S', 'L194T', 'L194Y', 'I195A', 'I195C', 'I195D', 'I195E', 'I195G', 'I195H', 'I195K', 'I195N', 'I195P', 'I195Q', 'I195R', 'I195S', 'I195T', 'I195W', 'I195Y', 'R196A', 'R196D', 'R196E', 'R196F', 'R196G', 'R196I', 'R196M', 'R196N', 'R196P', 'R196V', 'V197D', 'V197E', 'V197F', 'V197G', 'V197H', 'V197K', 'V197N', 'V197P', 'V197Q', 'V197R', 'V197W', 'V197Y', 'E198C', 'E198F', 'E198I', 'E198M', 'E198W', 'E198Y', 'G199F', 'G199I', 'G199K', 'G199L', 'G199M', 'G199P', 'G199R', 'G199T', 'G199V', 'G199W', 'G199Y', 'N200A', 'N200Q', 'N200Y', 'Y205A', 'Y205D', 'Y205E', 'Y205G', 'Y205K', 'Y205L', 'Y205M', 'Y205N', 'Y205P', 'Y205Q', 'Y205R', 'Y205S', 'Y205T', 'Y205V', 'Y205W', 'D208F', 'D208I', 'D208P', 'D208V', 'D208W', 'D208Y', 'T211C', 'T211F', 'T211H', 'T211L', 'T211M', 'T211P', 'T211R', 'T211V', 'T211W', 'T211Y', 'R213A', 'R213C', 'R213D', 'R213E', 'R213F', 'R213G', 'R213I', 'R213L', 'R213M', 'R213N', 'R213P', 'R213Q', 'R213S', 'R213T', 'R213V', 'R213W', 'R213Y', 'H214I', 'H214W', 'S215A', 'S215D', 'S215G', 'S215I', 'S215K', 'S215L', 'S215M', 'S215P', 'S215V', 'V216D', 'V216E', 'V216F', 'V216G', 'V216H', 'V216K', 'V216M', 'V216N', 'V216P', 'V216Q', 'V216R', 'V216S', 'V216T', 'V216W', 'V216Y', 'V218D', 'V218E', 'V218H', 'V218K', 'V218N', 'V218P', 'V218Q', 'V218R', 'V218W', 'P219G', 'Y220A', 'Y220C', 'Y220D', 'Y220E', 'Y220G', 'Y220K', 'Y220N', 'Y220P', 'Y220R', 'Y220S', 'Y220W', 'E221F', 'E221M', 'E221P', 'E221W', 'E221Y', 'P223D', 'P223F', 'P223G', 'P223H', 'P223I', 'P223K', 'P223R', 'P223W', 'P223Y', 'E224C', 'E224F', 'E224G', 'E224I', 'E224L', 'E224M', 'E224N', 'E224W', 'E224Y', 'V225F', 'V225W', 'V225Y', 'G226C', 'G226F', 'G226H', 'G226I', 'G226K', 'G226L', 'G226M', 'G226N', 'G226P', 'G226R', 'G226T', 'G226V', 'G226W', 'G226Y', 'D228Y', 'T230C', 'T230D', 'T230E', 'T230G', 'T230P', 'T231C', 'T231F', 'T231G', 'T231M', 'T231W', 'T231Y', 'I232K', 'I232P', 'I232Q', 'I232W', 'H233K', 'H233Q', 'H233W', 'Y234A', 'Y234C', 'Y234D', 'Y234E', 'Y234G', 'Y234H', 'Y234K', 'Y234M', 'Y234N', 'Y234P', 'Y234Q', 'Y234S', 'Y234V', 'Y234W', 'N235C', 'N235G', 'N235L', 'N235M', 'N235P', 'N235W', 'Y236N', 'Y236Q', 'Y236R', 'Y236W', 'M237C', 'M237D', 'M237E', 'M237H', 'M237N', 'M237Q', 'M237R', 'M237W', 'C238A', 'C238D', 'C238E', 'C238F', 'C238G', 'C238H', 'C238I', 'C238K', 'C238L', 'C238M', 'C238N', 'C238P', 'C238Q', 'C238R', 'C238S', 'C238T', 'C238V', 'C238W', 'C238Y', 'N239E', 'N239I', 'N239Q', 'N239V', 'N239W', 'S240F', 'S240P', 'S240W', 'S240Y', 'S241D', 'S241P', 'S241V', 'C242A', 'C242D', 'C242E', 'C242F', 'C242G', 'C242H', 'C242I', 'C242K', 'C242L', 'C242M', 'C242N', 'C242P', 'C242Q', 'C242R', 'C242S', 'C242T', 'C242V', 'C242W', 'C242Y', 'M243C', 'M243D', 'M243F', 'M243G', 'M243H', 'M243W', 'M243Y', 'G244A', 'G244C', 'G244E', 'G244I', 'G244M', 'G244N', 'G244R', 'G244V', 'G244W', 'G244Y', 'G245A', 'G245C', 'G245D', 'G245E', 'G245F', 'G245H', 'G245I', 'G245K', 'G245L', 'G245M', 'G245N', 'G245P', 'G245Q', 'G245V', 'G245W', 'G245Y', 'M246A', 'M246C', 'M246D', 'M246E', 'M246F', 'M246G', 'M246K', 'M246N', 'M246Q', 'M246R', 'M246S', 'M246T', 'M246V', 'M246W', 'M246Y', 'N247D', 'N247I', 'N247P', 'N247T', 'N247V', 'R248A', 'R248C', 'R248D', 'R248E', 'R248H', 'R248I', 'R248L', 'R248M', 'R248N', 'R248P', 'R248S', 'R248T', 'R248V', 'R249A', 'R249C', 'R249D', 'R249F', 'R249G', 'R249H', 'R249I', 'R249L', 'R249N', 'R249P', 'R249T', 'R249V', 'R249W', 'R249Y', 'I251A', 'I251C', 'I251D', 'I251E', 'I251F', 'I251G', 'I251H', 'I251K', 'I251N', 'I251P', 'I251Q', 'I251R', 'I251S', 'I251W', 'I251Y', 'L252P', 'T253D', 'T253E', 'T253F', 'T253G', 'T253H', 'T253K', 'T253P', 'T253R', 'T253W', 'T253Y', 'I254A', 'I254D', 'I254E', 'I254G', 'I254H', 'I254K', 'I254N', 'I254P', 'I254Q', 'I254R', 'I254S', 'I254T', 'I254W', 'I254Y', 'I255A', 'I255C', 'I255D', 'I255E', 'I255G', 'I255H', 'I255K', 'I255N', 'I255P', 'I255Q', 'I255R', 'I255S', 'I255T', 'T256G', 'L257A', 'L257C', 'L257D', 'L257E', 'L257F', 'L257G', 'L257H', 'L257K', 'L257N', 'L257P', 'L257Q', 'L257R', 'L257S', 'L257T', 'L257W', 'L257Y', 'E258D', 'E258G', 'E258K', 'E258N', 'E258P', 'E258W', 'D259W', 'G262C', 'G262F', 'G262H', 'G262I', 'G262L', 'G262M', 'G262P', 'G262S', 'G262V', 'G262W', 'G262Y', 'L264F', 'L264G', 'L264R', 'L264W', 'L264Y', 'L265A', 'L265D', 'L265E', 'L265G', 'L265K', 'L265N', 'L265P', 'L265Q', 'L265R', 'L265S', 'L265T', 'L265W', 'G266C', 'G266D', 'G266E', 'G266F', 'G266H', 'G266I', 'G266K', 'G266L', 'G266M', 'G266N', 'G266P', 'G266Q', 'G266R', 'G266S', 'G266T', 'G266V', 'G266W', 'G266Y', 'R267A', 'R267C', 'R267D', 'R267E', 'R267F', 'R267G', 'R267L', 'R267M', 'R267N', 'R267P', 'R267T', 'R267V', 'R267W', 'R267Y', 'S269D', 'S269E', 'S269G', 'S269H', 'S269P', 'S269Q', 'S269W', 'S269Y', 'F270A', 'F270C', 'F270D', 'F270E', 'F270G', 'F270H', 'F270K', 'F270N', 'F270P', 'F270Q', 'F270R', 'F270S', 'F270T', 'F270W', 'E271W', 'V272C', 'V272D', 'V272E', 'V272F', 'V272H', 'V272K', 'V272N', 'V272P', 'V272Q', 'V272R', 'V272S', 'V272W', 'V272Y', 'R273A', 'R273D', 'R273E', 'R273G', 'R273I', 'R273L', 'R273M', 'R273N', 'R273P', 'R273Q', 'R273S', 'R273T', 'R273V', 'R273W', 'V274D', 'V274E', 'V274F', 'V274G', 'V274H', 'V274K', 'V274N', 'V274Q', 'V274R', 'V274T', 'V274W', 'V274Y', 'C275A', 'C275E', 'C275F', 'C275G', 'C275H', 'C275I', 'C275K', 'C275L', 'C275M', 'C275N', 'C275P', 'C275Q', 'C275R', 'C275S', 'C275T', 'C275V', 'C275W', 'C275Y', 'A276C', 'A276F', 'A276G', 'A276M', 'A276P', 'C277A', 'C277D', 'C277E', 'C277F', 'C277G', 'C277H', 'C277K', 'C277P', 'C277R', 'C277W', 'C277Y', 'P278A', 'P278C', 'P278D', 'P278E', 'P278F', 'P278G', 'P278H', 'P278I', 'P278K', 'P278M', 'P278N', 'P278Q', 'P278R', 'P278T', 'P278V', 'P278W', 'P278Y', 'G279A', 'G279C', 'G279D', 'G279E', 'G279F', 'G279I', 'G279M', 'G279N', 'G279P', 'G279Q', 'G279V', 'G279W', 'G279Y', 'R280A', 'R280C', 'R280D', 'R280E', 'R280F', 'R280G', 'R280H', 'R280I', 'R280K', 'R280L', 'R280M', 'R280N', 'R280P', 'R280Q', 'R280S', 'R280T', 'R280V', 'R280W', 'R280Y', 'D281A', 'D281C', 'D281G', 'D281I', 'D281K', 'D281P', 'D281R', 'D281S', 'D281T', 'D281V', 'D281Y', 'R282C', 'R282D', 'R282E', 'R282G', 'R282H', 'R282N', 'R282P', 'R282T', 'R282V', 'R282W', 'R283P', 'T284C', 'T284D', 'T284F', 'T284P', 'T284W', 'E285C', 'E285G', 'E285N', 'E285P', 'E285S', 'E285T', 'E286A', 'E286C', 'E286G', 'E286N', 'E286P', 'E286S', 'E286T', 'N288C', 'N288P'] +- We aggregated all the variants that have at least one of the MAVISp modules with a predicted damaging effect (except for PTM.function) and retained only the ones with an AlphaMissense classification of Pathogenic for a total of 2219 variants which could be of interest for further investigation: + -- ['W91A', 'W91C', 'W91D', 'W91E', 'W91H', 'W91I', 'W91K', 'W91M', 'W91N', 'W91P', 'W91Q', 'W91R', 'W91T', 'P92F', 'P92W', 'P92Y', 'L93C', 'L93D', 'L93E', 'L93G', 'L93N', 'S94D', 'S94E', 'S94F', 'S94H', 'S94I', 'S94K', 'S94M', 'S94N', 'S94Q', 'S94R', 'S94V', 'S94W', 'S94Y', 'S95D', 'S95E', 'S95F', 'S95H', 'S95I', 'S95K', 'S95M', 'S95N', 'S95Q', 'S95R', 'S95W', 'S95Y', 'S96D', 'S96E', 'S96K', 'S96Q', 'S96R', 'V97A', 'V97C', 'V97D', 'V97F', 'V97G', 'V97H', 'V97K', 'V97L', 'V97M', 'V97N', 'V97P', 'V97R', 'V97S', 'V97T', 'V97W', 'V97Y', 'P98A', 'P98E', 'P98F', 'P98G', 'P98H', 'P98I', 'P98K', 'P98L', 'P98M', 'P98Q', 'P98R', 'P98S', 'P98V', 'P98W', 'P98Y', 'S99D', 'S99E', 'S99F', 'S99H', 'S99I', 'S99K', 'S99M', 'S99N', 'S99Q', 'S99R', 'S99W', 'S99Y', 'Q100C', 'K101C', 'K101F', 'K101P', 'K101W', 'T102W', 'Y103A', 'Y103D', 'Y103E', 'Y103G', 'Y103I', 'Y103K', 'Y103L', 'Y103M', 'Y103N', 'Y103P', 'Y103Q', 'Y103R', 'Y103S', 'Y103T', 'Y103V', 'G105A', 'G105C', 'G105D', 'G105E', 'G105F', 'G105H', 'G105I', 'G105K', 'G105L', 'G105M', 'G105N', 'G105P', 'G105Q', 'G105R', 'G105S', 'G105T', 'G105V', 'G105W', 'G105Y', 'Y107A', 'Y107D', 'Y107E', 'Y107G', 'Y107I', 'Y107K', 'Y107M', 'Y107P', 'Y107Q', 'Y107R', 'Y107T', 'G108I', 'G108L', 'G108M', 'G108P', 'G108V', 'G108W', 'G108Y', 'F109A', 'F109C', 'F109D', 'F109E', 'F109G', 'F109H', 'F109I', 'F109K', 'F109N', 'F109P', 'F109Q', 'F109R', 'F109S', 'F109T', 'F109V', 'F109Y', 'R110P', 'L111A', 'L111C', 'L111D', 'L111E', 'L111F', 'L111G', 'L111H', 'L111K', 'L111N', 'L111P', 'L111Q', 'L111R', 'L111S', 'L111T', 'L111W', 'L111Y', 'G112F', 'G112H', 'G112I', 'G112K', 'G112L', 'G112M', 'G112P', 'G112W', 'G112Y', 'F113A', 'F113C', 'F113D', 'F113E', 'F113G', 'F113H', 'F113I', 'F113K', 'F113L', 'F113M', 'F113N', 'F113P', 'F113Q', 'F113R', 'F113S', 'F113T', 'F113V', 'F113W', 'L114C', 'L114D', 'L114G', 'L114N', 'L114Y', 'S116D', 'S116E', 'S116F', 'S116H', 'S116I', 'S116K', 'S116M', 'S116N', 'S116P', 'S116Q', 'S116R', 'S116V', 'S116W', 'S116Y', 'G117C', 'G117D', 'G117E', 'G117F', 'G117H', 'G117I', 'G117K', 'G117L', 'G117M', 'G117N', 'G117P', 'G117Q', 'G117R', 'G117T', 'G117V', 'G117W', 'G117Y', 'T118C', 'T118G', 'A119G', 'K120A', 'K120C', 'K120D', 'K120E', 'K120G', 'K120H', 'K120M', 'K120N', 'K120P', 'K120Q', 'K120S', 'K120T', 'K120V', 'S121F', 'S121G', 'V122A', 'V122C', 'V122D', 'V122F', 'V122G', 'V122H', 'V122K', 'V122L', 'V122M', 'V122N', 'V122P', 'V122R', 'V122S', 'V122T', 'V122W', 'V122Y', 'T123C', 'T123E', 'T123F', 'T123G', 'T123H', 'T123I', 'T123K', 'T123Q', 'T123R', 'T123W', 'T123Y', 'C124A', 'C124D', 'C124E', 'C124G', 'C124H', 'C124I', 'C124K', 'C124L', 'C124M', 'C124N', 'C124P', 'C124Q', 'C124R', 'C124T', 'C124V', 'C124W', 'C124Y', 'T125A', 'T125C', 'T125D', 'T125E', 'T125F', 'T125G', 'T125H', 'T125I', 'T125K', 'T125M', 'T125N', 'T125P', 'T125Q', 'T125R', 'T125S', 'T125W', 'T125Y', 'Y126A', 'Y126C', 'Y126D', 'Y126E', 'Y126G', 'Y126H', 'Y126I', 'Y126K', 'Y126L', 'Y126M', 'Y126N', 'Y126P', 'Y126Q', 'Y126R', 'Y126S', 'Y126T', 'Y126V', 'S127C', 'S127D', 'S127E', 'S127F', 'S127G', 'S127H', 'S127I', 'S127K', 'S127L', 'S127M', 'S127N', 'S127P', 'S127Q', 'S127R', 'S127T', 'S127V', 'S127W', 'S127Y', 'L130A', 'L130C', 'L130D', 'L130E', 'L130F', 'L130G', 'L130H', 'L130K', 'L130N', 'L130P', 'L130Q', 'L130R', 'L130S', 'L130T', 'L130W', 'L130Y', 'N131A', 'N131F', 'N131I', 'N131L', 'N131M', 'N131P', 'N131V', 'N131W', 'K132D', 'K132E', 'K132F', 'K132G', 'K132P', 'K132W', 'K132Y', 'M133A', 'M133C', 'M133D', 'M133E', 'M133F', 'M133G', 'M133H', 'M133K', 'M133N', 'M133P', 'M133Q', 'M133R', 'M133S', 'M133T', 'M133W', 'M133Y', 'F134A', 'F134C', 'F134D', 'F134E', 'F134G', 'F134H', 'F134I', 'F134K', 'F134L', 'F134M', 'F134N', 'F134P', 'F134Q', 'F134R', 'F134S', 'F134T', 'F134V', 'C135A', 'C135D', 'C135E', 'C135F', 'C135G', 'C135H', 'C135I', 'C135K', 'C135L', 'C135M', 'C135N', 'C135P', 'C135Q', 'C135R', 'C135S', 'C135T', 'C135V', 'C135W', 'C135Y', 'Q136A', 'Q136C', 'Q136D', 'Q136E', 'Q136F', 'Q136G', 'Q136H', 'Q136I', 'Q136K', 'Q136L', 'Q136M', 'Q136N', 'Q136P', 'Q136R', 'Q136S', 'Q136T', 'Q136W', 'Q136Y', 'L137A', 'L137C', 'L137D', 'L137E', 'L137F', 'L137G', 'L137H', 'L137N', 'L137P', 'L137Q', 'L137R', 'L137S', 'L137T', 'L137W', 'L137Y', 'A138C', 'A138D', 'A138E', 'A138F', 'A138H', 'A138I', 'A138K', 'A138L', 'A138M', 'A138N', 'A138P', 'A138Q', 'A138R', 'A138T', 'A138V', 'A138W', 'A138Y', 'K139A', 'K139C', 'K139D', 'K139E', 'K139F', 'K139G', 'K139H', 'K139M', 'K139N', 'K139P', 'K139Q', 'K139S', 'K139T', 'K139V', 'K139W', 'K139Y', 'T140C', 'T140E', 'T140F', 'T140G', 'T140H', 'T140I', 'T140K', 'T140L', 'T140M', 'T140Q', 'T140R', 'T140S', 'T140V', 'T140W', 'T140Y', 'C141A', 'C141D', 'C141E', 'C141F', 'C141G', 'C141H', 'C141I', 'C141K', 'C141L', 'C141M', 'C141N', 'C141P', 'C141Q', 'C141R', 'C141S', 'C141T', 'C141V', 'C141W', 'C141Y', 'P142A', 'P142D', 'P142E', 'P142F', 'P142G', 'P142H', 'P142I', 'P142K', 'P142L', 'P142M', 'P142N', 'P142Q', 'P142R', 'P142S', 'P142V', 'P142W', 'P142Y', 'V143A', 'V143C', 'V143D', 'V143E', 'V143F', 'V143G', 'V143H', 'V143K', 'V143N', 'V143P', 'V143Q', 'V143R', 'V143S', 'V143T', 'V143W', 'V143Y', 'Q144A', 'Q144C', 'Q144D', 'Q144F', 'Q144G', 'Q144H', 'Q144I', 'Q144M', 'Q144N', 'Q144P', 'Q144S', 'Q144T', 'Q144W', 'Q144Y', 'L145A', 'L145C', 'L145D', 'L145E', 'L145G', 'L145H', 'L145K', 'L145N', 'L145P', 'L145Q', 'L145R', 'L145S', 'L145T', 'L145W', 'L145Y', 'W146C', 'W146D', 'W146E', 'W146K', 'W146N', 'W146P', 'W146Q', 'W146R', 'V147D', 'V147E', 'V147F', 'V147G', 'V147H', 'V147K', 'V147N', 'V147P', 'V147Q', 'V147R', 'V147S', 'V147W', 'V147Y', 'D148P', 'D148W', 'S149P', 'P151A', 'P151D', 'P151E', 'P151F', 'P151G', 'P151H', 'P151I', 'P151K', 'P151M', 'P151N', 'P151Q', 'P151R', 'P151S', 'P151T', 'P151V', 'P151W', 'P151Y', 'P152G', 'G154F', 'G154I', 'G154K', 'G154L', 'G154M', 'G154P', 'G154R', 'G154V', 'G154W', 'T155D', 'T155E', 'T155F', 'T155H', 'T155I', 'T155K', 'T155L', 'T155N', 'T155P', 'T155Q', 'T155R', 'T155W', 'T155Y', 'R156A', 'R156D', 'R156E', 'R156F', 'R156G', 'R156N', 'R156P', 'R156S', 'V157A', 'V157D', 'V157E', 'V157F', 'V157G', 'V157H', 'V157K', 'V157N', 'V157P', 'V157Q', 'V157R', 'V157S', 'V157T', 'V157W', 'V157Y', 'R158A', 'R158C', 'R158D', 'R158E', 'R158F', 'R158G', 'R158H', 'R158I', 'R158L', 'R158M', 'R158N', 'R158P', 'R158Q', 'R158S', 'R158T', 'R158V', 'R158W', 'R158Y', 'A159C', 'A159D', 'A159E', 'A159F', 'A159H', 'A159I', 'A159K', 'A159L', 'A159M', 'A159N', 'A159P', 'A159Q', 'A159R', 'A159V', 'A159W', 'A159Y', 'M160A', 'M160C', 'M160D', 'M160E', 'M160F', 'M160G', 'M160H', 'M160K', 'M160N', 'M160P', 'M160Q', 'M160R', 'M160S', 'M160W', 'M160Y', 'A161D', 'A161E', 'A161F', 'A161H', 'A161K', 'A161R', 'A161W', 'A161Y', 'I162D', 'I162E', 'I162F', 'I162G', 'I162H', 'I162K', 'I162N', 'I162P', 'I162Q', 'I162R', 'I162S', 'I162W', 'I162Y', 'Y163A', 'Y163C', 'Y163D', 'Y163E', 'Y163G', 'Y163H', 'Y163I', 'Y163K', 'Y163L', 'Y163M', 'Y163N', 'Y163P', 'Y163Q', 'Y163R', 'Y163S', 'Y163T', 'Y163V', 'Y163W', 'K164A', 'K164C', 'K164D', 'K164E', 'K164G', 'K164H', 'K164M', 'K164N', 'K164P', 'K164Q', 'K164S', 'K164T', 'K164V', 'Q165C', 'Q165D', 'Q165P', 'S166D', 'S166E', 'S166F', 'S166H', 'S166K', 'S166N', 'S166Q', 'S166R', 'S166W', 'S166Y', 'Q167C', 'Q167D', 'Q167F', 'Q167I', 'Q167M', 'Q167W', 'Q167Y', 'H168A', 'H168C', 'H168D', 'H168E', 'H168G', 'H168I', 'H168K', 'H168L', 'H168M', 'H168P', 'H168Q', 'H168R', 'H168S', 'H168T', 'H168V', 'H168W', 'M169A', 'M169C', 'M169D', 'M169E', 'M169G', 'M169H', 'M169N', 'M169P', 'M169Q', 'M169S', 'M169T', 'M169Y', 'T170C', 'T170E', 'T170F', 'T170H', 'T170I', 'T170K', 'T170Q', 'T170R', 'T170V', 'T170W', 'T170Y', 'E171A', 'E171C', 'E171G', 'E171N', 'E171P', 'E171S', 'E171T', 'V172A', 'V172C', 'V172D', 'V172E', 'V172F', 'V172G', 'V172H', 'V172K', 'V172N', 'V172P', 'V172R', 'V172S', 'V172T', 'V172W', 'V172Y', 'V173A', 'V173C', 'V173D', 'V173E', 'V173F', 'V173G', 'V173H', 'V173K', 'V173M', 'V173N', 'V173P', 'V173Q', 'V173R', 'V173S', 'V173T', 'V173W', 'V173Y', 'R174A', 'R174D', 'R174E', 'R174F', 'R174G', 'R174I', 'R174L', 'R174M', 'R174N', 'R174P', 'R174S', 'R174T', 'R174V', 'R174W', 'R174Y', 'R175A', 'R175C', 'R175D', 'R175E', 'R175F', 'R175G', 'R175H', 'R175I', 'R175L', 'R175M', 'R175N', 'R175P', 'R175Q', 'R175S', 'R175T', 'R175V', 'R175W', 'R175Y', 'C176A', 'C176E', 'C176F', 'C176G', 'C176H', 'C176I', 'C176K', 'C176L', 'C176M', 'C176N', 'C176P', 'C176Q', 'C176R', 'C176S', 'C176T', 'C176V', 'C176W', 'C176Y', 'P177E', 'P177F', 'P177H', 'P177I', 'P177K', 'P177L', 'P177M', 'P177Q', 'P177R', 'P177V', 'P177W', 'P177Y', 'H178A', 'H178C', 'H178D', 'H178E', 'H178F', 'H178G', 'H178I', 'H178K', 'H178L', 'H178M', 'H178N', 'H178P', 'H178Q', 'H178R', 'H178S', 'H178T', 'H178V', 'H178W', 'H178Y', 'H179A', 'H179C', 'H179D', 'H179E', 'H179F', 'H179G', 'H179I', 'H179K', 'H179L', 'H179M', 'H179N', 'H179P', 'H179Q', 'H179R', 'H179S', 'H179T', 'H179V', 'H179W', 'H179Y', 'E180A', 'E180C', 'E180D', 'E180F', 'E180G', 'E180H', 'E180I', 'E180K', 'E180L', 'E180M', 'E180N', 'E180P', 'E180Q', 'E180R', 'E180S', 'E180T', 'E180W', 'E180Y', 'R181A', 'R181C', 'R181D', 'R181E', 'R181F', 'R181G', 'R181H', 'R181I', 'R181L', 'R181M', 'R181N', 'R181P', 'R181S', 'R181T', 'R181V', 'R181W', 'R181Y', 'C182E', 'C182K', 'C182M', 'C182P', 'C182Q', 'C182R', 'C182W', 'S183D', 'S183E', 'S183K', 'S183Q', 'S183R', 'D184F', 'D184I', 'D184K', 'D184L', 'D184M', 'D184R', 'D184W', 'S185E', 'S185K', 'S185R', 'D186A', 'D186F', 'D186H', 'D186I', 'D186K', 'D186L', 'D186M', 'D186Q', 'D186R', 'D186V', 'D186W', 'D186Y', 'G187F', 'G187H', 'G187K', 'G187L', 'G187M', 'G187P', 'G187Q', 'G187R', 'G187W', 'G187Y', 'L188C', 'L188D', 'A189D', 'A189E', 'A189F', 'A189G', 'A189H', 'A189K', 'A189P', 'A189Q', 'A189R', 'A189W', 'A189Y', 'P190E', 'P190F', 'P190G', 'P190H', 'P190I', 'P190K', 'P190L', 'P190M', 'P190Q', 'P190R', 'P190S', 'P190T', 'P190V', 'P190W', 'P190Y', 'P191E', 'P191F', 'P191G', 'P191H', 'P191I', 'P191K', 'P191L', 'P191M', 'P191V', 'P191W', 'P191Y', 'Q192C', 'Q192D', 'Q192F', 'Q192I', 'Q192M', 'Q192W', 'Q192Y', 'H193A', 'H193C', 'H193D', 'H193E', 'H193F', 'H193G', 'H193I', 'H193K', 'H193L', 'H193M', 'H193N', 'H193P', 'H193Q', 'H193R', 'H193S', 'H193T', 'H193V', 'H193W', 'H193Y', 'L194A', 'L194C', 'L194D', 'L194E', 'L194G', 'L194H', 'L194K', 'L194N', 'L194P', 'L194Q', 'L194R', 'L194S', 'L194T', 'L194V', 'L194W', 'L194Y', 'I195A', 'I195C', 'I195D', 'I195E', 'I195F', 'I195G', 'I195H', 'I195K', 'I195N', 'I195P', 'I195Q', 'I195R', 'I195S', 'I195T', 'I195W', 'I195Y', 'R196A', 'R196C', 'R196D', 'R196E', 'R196F', 'R196G', 'R196H', 'R196I', 'R196L', 'R196M', 'R196N', 'R196P', 'R196Q', 'R196S', 'R196T', 'R196V', 'R196W', 'R196Y', 'V197A', 'V197C', 'V197D', 'V197E', 'V197F', 'V197G', 'V197H', 'V197K', 'V197L', 'V197M', 'V197N', 'V197P', 'V197Q', 'V197R', 'V197S', 'V197T', 'V197W', 'V197Y', 'E198A', 'E198C', 'E198D', 'E198F', 'E198G', 'E198H', 'E198I', 'E198K', 'E198L', 'E198M', 'E198N', 'E198P', 'E198Q', 'E198R', 'E198S', 'E198T', 'E198W', 'E198Y', 'G199A', 'G199C', 'G199D', 'G199E', 'G199F', 'G199H', 'G199I', 'G199K', 'G199L', 'G199M', 'G199N', 'G199P', 'G199Q', 'G199R', 'G199S', 'G199T', 'G199V', 'G199W', 'G199Y', 'N200A', 'N200C', 'N200E', 'N200F', 'N200G', 'N200I', 'N200K', 'N200L', 'N200M', 'N200P', 'N200Q', 'N200R', 'N200V', 'N200W', 'N200Y', 'V203C', 'V203D', 'V203E', 'V203F', 'V203H', 'V203K', 'V203L', 'V203M', 'V203N', 'V203P', 'V203Q', 'V203R', 'V203W', 'V203Y', 'E204C', 'E204F', 'E204P', 'E204W', 'E204Y', 'Y205A', 'Y205C', 'Y205D', 'Y205E', 'Y205G', 'Y205H', 'Y205I', 'Y205K', 'Y205L', 'Y205M', 'Y205N', 'Y205P', 'Y205Q', 'Y205R', 'Y205S', 'Y205T', 'Y205V', 'Y205W', 'L206D', 'L206P', 'D207F', 'D207H', 'D207I', 'D207K', 'D207L', 'D207M', 'D207Q', 'D207R', 'D207W', 'D207Y', 'D208A', 'D208E', 'D208F', 'D208G', 'D208H', 'D208I', 'D208K', 'D208L', 'D208M', 'D208P', 'D208Q', 'D208R', 'D208S', 'D208V', 'D208W', 'D208Y', 'N210W', 'T211A', 'T211C', 'T211D', 'T211E', 'T211F', 'T211G', 'T211H', 'T211I', 'T211K', 'T211L', 'T211M', 'T211P', 'T211Q', 'T211R', 'T211V', 'T211W', 'T211Y', 'F212I', 'F212P', 'F212T', 'R213A', 'R213C', 'R213D', 'R213E', 'R213F', 'R213G', 'R213H', 'R213I', 'R213L', 'R213M', 'R213N', 'R213P', 'R213Q', 'R213S', 'R213T', 'R213V', 'R213W', 'R213Y', 'H214F', 'H214I', 'H214K', 'H214L', 'H214M', 'H214R', 'H214W', 'H214Y', 'S215A', 'S215D', 'S215G', 'S215I', 'S215K', 'S215L', 'S215M', 'S215P', 'S215T', 'S215V', 'V216A', 'V216C', 'V216D', 'V216E', 'V216F', 'V216G', 'V216H', 'V216K', 'V216M', 'V216N', 'V216P', 'V216Q', 'V216R', 'V216S', 'V216T', 'V216W', 'V216Y', 'V217D', 'V217E', 'V217F', 'V217G', 'V217H', 'V217K', 'V217N', 'V217P', 'V217Q', 'V217R', 'V217W', 'V217Y', 'V218A', 'V218C', 'V218D', 'V218E', 'V218F', 'V218G', 'V218H', 'V218K', 'V218N', 'V218P', 'V218Q', 'V218R', 'V218S', 'V218T', 'V218W', 'V218Y', 'P219G', 'Y220A', 'Y220C', 'Y220D', 'Y220E', 'Y220G', 'Y220H', 'Y220I', 'Y220K', 'Y220L', 'Y220M', 'Y220N', 'Y220P', 'Y220Q', 'Y220R', 'Y220S', 'Y220T', 'Y220V', 'Y220W', 'E221A', 'E221C', 'E221F', 'E221G', 'E221H', 'E221I', 'E221K', 'E221L', 'E221M', 'E221N', 'E221P', 'E221R', 'E221S', 'E221T', 'E221W', 'E221Y', 'P222W', 'P223D', 'P223F', 'P223G', 'P223H', 'P223I', 'P223K', 'P223L', 'P223N', 'P223R', 'P223V', 'P223W', 'P223Y', 'E224A', 'E224C', 'E224D', 'E224F', 'E224G', 'E224H', 'E224I', 'E224K', 'E224L', 'E224M', 'E224N', 'E224P', 'E224R', 'E224S', 'E224T', 'E224W', 'E224Y', 'V225C', 'V225D', 'V225H', 'V225K', 'V225N', 'V225R', 'V225W', 'V225Y', 'G226A', 'G226C', 'G226D', 'G226E', 'G226F', 'G226H', 'G226I', 'G226K', 'G226L', 'G226M', 'G226N', 'G226P', 'G226Q', 'G226R', 'G226S', 'G226T', 'G226V', 'G226W', 'G226Y', 'S227P', 'D228F', 'D228M', 'D228W', 'C229P', 'T230D', 'T230E', 'T230G', 'T230P', 'T231C', 'T231E', 'T231F', 'T231G', 'T231H', 'T231I', 'T231K', 'T231Q', 'T231R', 'T231S', 'T231W', 'T231Y', 'I232A', 'I232C', 'I232D', 'I232E', 'I232F', 'I232G', 'I232H', 'I232K', 'I232N', 'I232P', 'I232Q', 'I232R', 'I232S', 'I232T', 'I232W', 'I232Y', 'H233A', 'H233C', 'H233D', 'H233E', 'H233F', 'H233G', 'H233I', 'H233K', 'H233M', 'H233N', 'H233P', 'H233Q', 'H233R', 'H233S', 'H233T', 'H233V', 'H233W', 'Y234A', 'Y234C', 'Y234D', 'Y234E', 'Y234G', 'Y234H', 'Y234I', 'Y234K', 'Y234M', 'Y234N', 'Y234P', 'Y234Q', 'Y234R', 'Y234S', 'Y234T', 'Y234V', 'Y234W', 'N235A', 'N235E', 'N235F', 'N235G', 'N235I', 'N235K', 'N235L', 'N235M', 'N235P', 'N235Q', 'N235R', 'N235V', 'N235W', 'N235Y', 'Y236A', 'Y236C', 'Y236D', 'Y236E', 'Y236G', 'Y236H', 'Y236I', 'Y236K', 'Y236L', 'Y236M', 'Y236N', 'Y236P', 'Y236Q', 'Y236R', 'Y236S', 'Y236T', 'Y236V', 'Y236W', 'M237A', 'M237C', 'M237D', 'M237E', 'M237F', 'M237G', 'M237H', 'M237K', 'M237N', 'M237P', 'M237Q', 'M237R', 'M237S', 'M237T', 'M237V', 'M237W', 'M237Y', 'C238A', 'C238D', 'C238E', 'C238F', 'C238G', 'C238H', 'C238I', 'C238K', 'C238L', 'C238M', 'C238N', 'C238P', 'C238Q', 'C238R', 'C238S', 'C238T', 'C238V', 'C238W', 'C238Y', 'N239E', 'N239F', 'N239H', 'N239I', 'N239K', 'N239L', 'N239M', 'N239Q', 'N239R', 'N239V', 'N239W', 'N239Y', 'S240F', 'S240G', 'S240P', 'S240W', 'S240Y', 'S241D', 'S241P', 'S241V', 'C242A', 'C242D', 'C242E', 'C242F', 'C242G', 'C242H', 'C242I', 'C242K', 'C242L', 'C242M', 'C242N', 'C242P', 'C242Q', 'C242R', 'C242S', 'C242T', 'C242V', 'C242W', 'C242Y', 'M243A', 'M243C', 'M243D', 'M243E', 'M243F', 'M243G', 'M243H', 'M243K', 'M243N', 'M243P', 'M243Q', 'M243R', 'M243S', 'M243T', 'M243V', 'M243W', 'M243Y', 'G244A', 'G244C', 'G244D', 'G244E', 'G244F', 'G244H', 'G244I', 'G244K', 'G244L', 'G244M', 'G244N', 'G244P', 'G244Q', 'G244R', 'G244S', 'G244T', 'G244V', 'G244W', 'G244Y', 'G245A', 'G245C', 'G245D', 'G245E', 'G245F', 'G245H', 'G245I', 'G245K', 'G245L', 'G245M', 'G245N', 'G245P', 'G245Q', 'G245R', 'G245S', 'G245T', 'G245V', 'G245W', 'G245Y', 'M246A', 'M246C', 'M246D', 'M246E', 'M246F', 'M246G', 'M246H', 'M246K', 'M246N', 'M246P', 'M246Q', 'M246R', 'M246S', 'M246T', 'M246V', 'M246W', 'M246Y', 'N247D', 'N247I', 'N247P', 'N247T', 'N247V', 'R248A', 'R248C', 'R248D', 'R248E', 'R248G', 'R248H', 'R248I', 'R248L', 'R248M', 'R248N', 'R248P', 'R248Q', 'R248S', 'R248T', 'R248V', 'R249A', 'R249C', 'R249D', 'R249E', 'R249F', 'R249G', 'R249H', 'R249I', 'R249L', 'R249M', 'R249N', 'R249P', 'R249Q', 'R249S', 'R249T', 'R249V', 'R249W', 'R249Y', 'P250G', 'P250S', 'I251A', 'I251C', 'I251D', 'I251E', 'I251F', 'I251G', 'I251H', 'I251K', 'I251N', 'I251P', 'I251Q', 'I251R', 'I251S', 'I251T', 'I251W', 'I251Y', 'L252D', 'L252G', 'L252H', 'L252P', 'L252S', 'T253D', 'T253E', 'T253F', 'T253G', 'T253H', 'T253K', 'T253N', 'T253P', 'T253R', 'T253W', 'T253Y', 'I254A', 'I254D', 'I254E', 'I254G', 'I254H', 'I254K', 'I254N', 'I254P', 'I254Q', 'I254R', 'I254S', 'I254T', 'I254W', 'I254Y', 'I255A', 'I255C', 'I255D', 'I255E', 'I255F', 'I255G', 'I255H', 'I255K', 'I255N', 'I255P', 'I255Q', 'I255R', 'I255S', 'I255T', 'I255W', 'I255Y', 'T256G', 'T256P', 'L257A', 'L257C', 'L257D', 'L257E', 'L257F', 'L257G', 'L257H', 'L257K', 'L257N', 'L257P', 'L257Q', 'L257R', 'L257S', 'L257T', 'L257W', 'L257Y', 'E258D', 'E258G', 'E258K', 'E258N', 'E258P', 'E258R', 'E258W', 'D259A', 'D259C', 'D259E', 'D259F', 'D259G', 'D259H', 'D259I', 'D259K', 'D259L', 'D259M', 'D259P', 'D259Q', 'D259R', 'D259T', 'D259V', 'D259W', 'D259Y', 'S261P', 'G262A', 'G262C', 'G262D', 'G262E', 'G262F', 'G262H', 'G262I', 'G262K', 'G262L', 'G262M', 'G262N', 'G262P', 'G262Q', 'G262R', 'G262S', 'G262T', 'G262V', 'G262W', 'G262Y', 'N263P', 'N263W', 'L264F', 'L264G', 'L264R', 'L264W', 'L264Y', 'L265A', 'L265D', 'L265E', 'L265G', 'L265H', 'L265K', 'L265N', 'L265P', 'L265Q', 'L265R', 'L265S', 'L265T', 'L265W', 'G266C', 'G266D', 'G266E', 'G266F', 'G266H', 'G266I', 'G266K', 'G266L', 'G266M', 'G266N', 'G266P', 'G266Q', 'G266R', 'G266S', 'G266T', 'G266V', 'G266W', 'G266Y', 'R267A', 'R267C', 'R267D', 'R267E', 'R267F', 'R267G', 'R267H', 'R267I', 'R267L', 'R267M', 'R267N', 'R267P', 'R267Q', 'R267S', 'R267T', 'R267V', 'R267W', 'R267Y', 'N268P', 'S269D', 'S269E', 'S269F', 'S269H', 'S269K', 'S269P', 'S269Q', 'S269R', 'S269W', 'S269Y', 'F270A', 'F270C', 'F270D', 'F270E', 'F270G', 'F270H', 'F270I', 'F270K', 'F270L', 'F270M', 'F270N', 'F270P', 'F270Q', 'F270R', 'F270S', 'F270T', 'F270V', 'F270W', 'E271W', 'V272A', 'V272C', 'V272D', 'V272E', 'V272F', 'V272G', 'V272H', 'V272K', 'V272N', 'V272P', 'V272Q', 'V272R', 'V272S', 'V272T', 'V272W', 'V272Y', 'R273A', 'R273C', 'R273D', 'R273E', 'R273G', 'R273H', 'R273I', 'R273L', 'R273M', 'R273N', 'R273P', 'R273Q', 'R273S', 'R273T', 'R273V', 'R273W', 'V274A', 'V274D', 'V274E', 'V274F', 'V274G', 'V274H', 'V274K', 'V274N', 'V274P', 'V274Q', 'V274R', 'V274S', 'V274T', 'V274W', 'V274Y', 'C275A', 'C275E', 'C275F', 'C275G', 'C275H', 'C275I', 'C275K', 'C275L', 'C275M', 'C275N', 'C275P', 'C275Q', 'C275R', 'C275S', 'C275T', 'C275V', 'C275W', 'C275Y', 'A276C', 'A276F', 'A276G', 'A276K', 'A276M', 'A276P', 'A276T', 'C277A', 'C277D', 'C277E', 'C277F', 'C277G', 'C277H', 'C277K', 'C277P', 'C277R', 'C277S', 'C277W', 'C277Y', 'P278A', 'P278C', 'P278D', 'P278E', 'P278F', 'P278G', 'P278H', 'P278I', 'P278K', 'P278L', 'P278M', 'P278N', 'P278Q', 'P278R', 'P278S', 'P278T', 'P278V', 'P278W', 'P278Y', 'G279A', 'G279C', 'G279D', 'G279E', 'G279F', 'G279H', 'G279I', 'G279K', 'G279L', 'G279M', 'G279N', 'G279P', 'G279Q', 'G279R', 'G279S', 'G279T', 'G279V', 'G279W', 'G279Y', 'R280A', 'R280C', 'R280D', 'R280E', 'R280F', 'R280G', 'R280H', 'R280I', 'R280K', 'R280L', 'R280M', 'R280N', 'R280P', 'R280Q', 'R280S', 'R280T', 'R280V', 'R280W', 'R280Y', 'D281A', 'D281C', 'D281G', 'D281I', 'D281K', 'D281P', 'D281R', 'D281S', 'D281T', 'D281V', 'D281Y', 'R282A', 'R282C', 'R282D', 'R282E', 'R282G', 'R282H', 'R282I', 'R282L', 'R282M', 'R282N', 'R282P', 'R282Q', 'R282S', 'R282T', 'R282V', 'R282W', 'R283P', 'T284C', 'T284D', 'T284E', 'T284F', 'T284H', 'T284I', 'T284K', 'T284P', 'T284Q', 'T284R', 'T284W', 'E285A', 'E285C', 'E285D', 'E285G', 'E285N', 'E285P', 'E285S', 'E285T', 'E286A', 'E286C', 'E286D', 'E286G', 'E286N', 'E286P', 'E286S', 'E286T', 'E287C', 'E287P', 'N288C', 'N288G', 'N288P', 'L289P'] + +- Experimental classification not available. + +- We identified continuous stretches of residues that are above a pre-determined threshold of a minimum length of 3 residues to assign whether each residue is part of a early folding region totalling to 741 variants. See csv file for details. + + +Not reported ClinVar Germline Interpretation in clinvar: 2970 +ClinVar Germline Interpretation +benign 5 +conflicting classifications of pathogenicity 232 +conflicting classifications of pathogenicity, conflicting classifications of pathogenicity 2 +conflicting classifications of pathogenicity, conflicting classifications of pathogenicity, conflicting classifications of pathogenicity 1 +conflicting classifications of pathogenicity, pathogenic/likely pathogenic 4 +likely benign 35 +likely benign, uncertain significance 1 +likely pathogenic 29 +likely pathogenic, conflicting classifications of pathogenicity 2 +likely pathogenic, conflicting classifications of pathogenicity, pathogenic/likely pathogenic 1 +likely pathogenic, pathogenic 1 +likely pathogenic, pathogenic/likely pathogenic 2 +not provided 1 +pathogenic 62 +pathogenic, conflicting classifications of pathogenicity 1 +pathogenic, pathogenic 3 +pathogenic, pathogenic, likely pathogenic 1 +pathogenic, pathogenic/likely pathogenic 4 +pathogenic/likely pathogenic 94 +pathogenic/likely pathogenic, conflicting classifications of pathogenicity 1 +pathogenic/likely pathogenic, likely pathogenic 1 +pathogenic/likely pathogenic, pathogenic 1 +pathogenic/likely pathogenic, pathogenic/likely pathogenic 1 +pathogenic/likely pathogenic, pathogenic/likely pathogenic, pathogenic 1 +uncertain significance 302 +uncertain significance, conflicting classifications of pathogenicity 6 +uncertain significance, conflicting classifications of pathogenicity, conflicting classifications of pathogenicity 1 +uncertain significance, conflicting classifications of pathogenicity, uncertain significance 2 +uncertain significance, likely benign 1 +uncertain significance, uncertain significance 13 +Name: ClinVar Germline Interpretation, dtype: int64 diff --git a/dot_plot/examples_v2/simple_mode_popeve/mechanistic_indicators_out.csv b/dot_plot/examples_v2/simple_mode_popeve/mechanistic_indicators_out.csv new file mode 100644 index 0000000..09aeb3e --- /dev/null +++ b/dot_plot/examples_v2/simple_mode_popeve/mechanistic_indicators_out.csv @@ -0,0 +1,2020 @@ +Mutation,"Stability classification, alphafold, (Rosetta, FoldX)","Stability classification, alphafold, (RaSP, FoldX)","Stability classification, alphafold, (ThermoMPNN)","Stability classification, alphafold, (Foldetta from FoldX and Rosetta)","Stability classification, alphafold, (Foldetta from FoldX and RaSP)",Local Int. classification (TP53BP1_AFmulti),Local Int. With DNA classification (3KZ8b),Local Int. classification (TP53_2OCJbd),PTM effect in regulation,PTM effect in stability,PTM effect in function,AlloSigMA 2 predicted consequence - pockets and interfaces,Functional sites (cofactor),Loss of disulfide bridge,Predicted de-novo disulfide bridge,MAVISp Effects +W91A,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +W91C,uncertain,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +W91D,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +W91E,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +W91H,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +W91I,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +W91K,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +W91M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +W91N,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +W91P,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +W91Q,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +W91R,uncertain,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +W91T,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P92F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P92W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P92Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L93D,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L93E,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L93G,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97A,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97D,neutral,uncertain,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V97F,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97G,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V97H,uncertain,neutral,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97K,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97M,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97N,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97P,neutral,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97R,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97S,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97T,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97W,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V97Y,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98A,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98E,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98G,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98H,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98K,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98L,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98Q,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98R,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98S,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98V,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P98Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +S99D,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,damaging,neutral,uncertain,stabilizing,neutral,neutral,neutral,"PTM, Long Range" +S99H,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,damaging,neutral,uncertain,stabilizing,neutral,neutral,neutral,"PTM, Long Range" +S99K,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,damaging,neutral,uncertain,stabilizing,neutral,neutral,neutral,"PTM, Long Range" +S99M,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,damaging,neutral,uncertain,stabilizing,neutral,neutral,neutral,"PTM, Long Range" +S99R,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,damaging,neutral,uncertain,stabilizing,neutral,neutral,neutral,"PTM, Long Range" +S99W,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,damaging,neutral,uncertain,stabilizing,neutral,neutral,neutral,"PTM, Long Range" +S99Y,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,stabilizing,neutral,neutral,neutral,Long Range +K101F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K101P,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K101W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +T102W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +Y103A,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y103D,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y103E,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y103G,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y103I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y103K,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y103L,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y103M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y103N,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y103P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y103Q,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y103R,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y103S,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y103T,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y103V,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +G105A,uncertain,destabilizing,destabilizing,uncertain,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105D,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105F,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105H,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105I,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105K,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105L,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105M,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105N,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105Q,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105S,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105T,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105V,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105W,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G105Y,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +Y107A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y107D,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y107E,uncertain,destabilizing,destabilizing,uncertain,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y107G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y107I,neutral,uncertain,destabilizing,neutral,uncertain,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y107K,uncertain,uncertain,destabilizing,uncertain,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y107M,neutral,uncertain,uncertain,neutral,neutral,,,,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +Y107P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y107Q,uncertain,uncertain,destabilizing,uncertain,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y107R,uncertain,uncertain,destabilizing,uncertain,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y107T,uncertain,destabilizing,destabilizing,uncertain,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G108I,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G108P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G108W,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G108Y,uncertain,uncertain,uncertain,uncertain,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109H,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109I,uncertain,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109T,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109V,uncertain,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +F109Y,neutral,neutral,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +R110P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L111A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +L111C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +L111D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +L111E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +L111F,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L111G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +L111H,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +L111K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +L111N,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +L111P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +L111Q,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +L111R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L111S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +L111T,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +L111W,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L111Y,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G112F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G112K,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G112P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G112W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G112Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +F113A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113H,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113I,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113L,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +F113M,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +F113N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113T,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113V,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F113W,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L114C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L114D,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L114G,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L114N,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L114Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +S116D,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S116E,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S116F,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S116H,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S116I,uncertain,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S116K,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S116M,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S116P,neutral,uncertain,uncertain,neutral,uncertain,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S116Q,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S116R,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S116V,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S116W,uncertain,uncertain,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S116Y,uncertain,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +G117C,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117D,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117E,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117F,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117H,uncertain,uncertain,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117I,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117K,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117L,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117M,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117N,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117P,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117Q,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117R,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117T,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117V,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117W,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G117Y,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +T118C,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,destabilizing,neutral,neutral,neutral,Long Range +T118G,uncertain,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,destabilizing,neutral,neutral,neutral,Long Range +A119G,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +K120A,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +K120C,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,damaging,"Long Range, Disulfide bridges" +K120D,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +K120E,neutral,neutral,neutral,neutral,neutral,neutral,destabilizing,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +K120G,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +K120H,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +K120M,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K120N,neutral,neutral,neutral,neutral,neutral,neutral,destabilizing,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +K120P,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +K120Q,neutral,neutral,neutral,neutral,neutral,neutral,destabilizing,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +K120S,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K120T,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K120V,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +S121F,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,uncertain,uncertain,,,neutral,neutral,neutral,neutral,Local Int. +V122C,neutral,uncertain,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V122D,neutral,uncertain,neutral,neutral,uncertain,,neutral,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V122F,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V122G,uncertain,uncertain,uncertain,uncertain,uncertain,,neutral,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V122H,uncertain,uncertain,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V122K,uncertain,uncertain,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V122M,neutral,neutral,neutral,neutral,neutral,neutral,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V122N,uncertain,uncertain,neutral,uncertain,neutral,,neutral,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V122P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V122R,uncertain,uncertain,neutral,uncertain,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V122S,uncertain,uncertain,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V122T,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V122W,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V122Y,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +T123C,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T123E,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T123F,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T123G,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T123H,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T123K,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T123Q,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T123R,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T123W,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T123Y,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +C124A,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,damaging,neutral,"Long Range, Disulfide bridges" +C124D,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,uncertain,neutral,damaging,neutral,Disulfide bridges +C124E,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C124G,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,damaging,neutral,"Long Range, Disulfide bridges" +C124H,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C124I,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C124K,neutral,neutral,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,"Stability, Disulfide bridges" +C124L,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C124M,uncertain,uncertain,neutral,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C124N,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C124P,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,damaging,neutral,"Stability, Disulfide bridges" +C124Q,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C124R,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C124T,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C124V,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C124Y,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +T125A,neutral,neutral,neutral,neutral,neutral,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +T125C,neutral,neutral,neutral,neutral,neutral,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +T125D,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,,uncertain,,,uncertain,neutral,neutral,neutral,Stability +T125E,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T125F,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T125G,uncertain,uncertain,uncertain,uncertain,neutral,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +T125H,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T125I,destabilizing,uncertain,neutral,destabilizing,uncertain,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T125K,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T125M,uncertain,uncertain,uncertain,destabilizing,uncertain,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T125N,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,uncertain,,,uncertain,neutral,neutral,neutral,Stability +T125P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,uncertain,neutral,neutral,neutral,Stability +T125Q,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T125R,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T125S,neutral,neutral,neutral,neutral,neutral,,,,neutral,,,mixed_effects,neutral,neutral,neutral,Long Range +T125W,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T125Y,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +Y126A,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126C,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126H,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126I,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,uncertain,uncertain,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y126K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126L,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,uncertain,uncertain,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y126M,uncertain,uncertain,destabilizing,uncertain,neutral,,,,uncertain,neutral,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y126N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126R,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126T,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y126V,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,uncertain,damaging,uncertain,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +S127C,neutral,neutral,uncertain,neutral,neutral,,,,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S127D,neutral,uncertain,uncertain,neutral,neutral,,,,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S127E,neutral,uncertain,destabilizing,neutral,uncertain,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127F,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127G,uncertain,neutral,destabilizing,uncertain,neutral,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127H,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127I,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127L,neutral,uncertain,destabilizing,neutral,neutral,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127M,uncertain,uncertain,destabilizing,neutral,neutral,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127N,neutral,uncertain,uncertain,neutral,neutral,,,,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +S127P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127Q,uncertain,uncertain,destabilizing,uncertain,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127T,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,,,stabilizing,neutral,neutral,neutral,Long Range +S127V,neutral,neutral,destabilizing,neutral,neutral,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127W,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +S127Y,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130A,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130C,neutral,uncertain,uncertain,neutral,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L130D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130F,uncertain,neutral,uncertain,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L130G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130H,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130K,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +L130N,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130P,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130Q,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130R,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130S,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130T,uncertain,uncertain,destabilizing,neutral,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130W,uncertain,neutral,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L130Y,uncertain,neutral,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +N131F,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +N131L,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +N131P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +N131V,destabilizing,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +N131W,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K132D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +K132E,uncertain,uncertain,uncertain,uncertain,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +K132F,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +K132G,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +K132P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +K132W,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +K132Y,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M133A,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133C,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Disulfide bridges +M133D,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133E,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133F,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M133G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133H,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133K,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M133N,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133Q,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133R,uncertain,uncertain,destabilizing,destabilizing,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M133S,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133T,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +M133W,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M133Y,neutral,neutral,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134H,destabilizing,uncertain,uncertain,destabilizing,uncertain,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134I,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +F134K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134L,uncertain,uncertain,destabilizing,neutral,uncertain,neutral,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134M,uncertain,uncertain,uncertain,neutral,neutral,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +F134N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134T,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +F134V,uncertain,uncertain,destabilizing,uncertain,destabilizing,neutral,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +C135A,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +C135D,uncertain,uncertain,destabilizing,destabilizing,uncertain,,neutral,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +C135E,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +C135F,uncertain,uncertain,neutral,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +C135G,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +C135H,uncertain,uncertain,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +C135I,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C135K,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +C135L,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C135M,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C135N,neutral,neutral,destabilizing,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +C135P,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +C135Q,uncertain,uncertain,uncertain,uncertain,uncertain,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C135R,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +C135S,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +C135T,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C135V,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C135W,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +C135Y,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Q136A,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +Q136C,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +Q136D,neutral,neutral,destabilizing,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Q136E,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +Q136F,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q136G,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +Q136H,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q136I,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q136K,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q136L,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q136M,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q136N,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +Q136P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Q136S,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +Q136T,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +Q136W,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q136Y,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L137A,neutral,uncertain,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L137C,neutral,uncertain,neutral,neutral,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L137D,neutral,uncertain,destabilizing,neutral,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L137E,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L137G,uncertain,uncertain,destabilizing,uncertain,destabilizing,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L137H,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L137N,neutral,uncertain,destabilizing,neutral,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L137P,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L137Q,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L137R,neutral,uncertain,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L137S,uncertain,uncertain,destabilizing,neutral,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L137T,neutral,uncertain,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L137W,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L137Y,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138D,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138E,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138H,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138I,uncertain,neutral,neutral,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138K,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138L,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138N,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,uncertain,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A138Q,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138R,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138T,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138V,uncertain,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A138Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139A,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139D,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139E,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139G,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139H,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139N,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +K139S,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139T,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139V,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K139Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +T140C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +T140E,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T140F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T140G,uncertain,uncertain,neutral,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +T140H,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T140I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T140K,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T140L,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T140M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T140Q,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T140R,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T140V,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T140W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T140Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +C141A,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C141D,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,uncertain,neutral,damaging,neutral,"Stability, Disulfide bridges" +C141E,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,"Stability, Disulfide bridges" +C141F,destabilizing,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,"Stability, Disulfide bridges" +C141G,destabilizing,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,"Stability, Disulfide bridges" +C141H,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,"Stability, Disulfide bridges" +C141I,uncertain,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C141K,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,"Stability, Disulfide bridges" +C141L,uncertain,uncertain,neutral,uncertain,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C141M,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C141N,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C141P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,damaging,neutral,"Stability, Disulfide bridges" +C141Q,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,"Stability, Disulfide bridges" +C141R,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,"Stability, Disulfide bridges" +C141S,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C141T,uncertain,uncertain,neutral,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C141V,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,Disulfide bridges +C141W,destabilizing,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,"Stability, Disulfide bridges" +C141Y,uncertain,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,damaging,neutral,"Stability, Disulfide bridges" +P142A,uncertain,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +P142D,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +P142E,uncertain,neutral,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P142F,uncertain,uncertain,uncertain,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P142G,uncertain,uncertain,destabilizing,destabilizing,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +P142H,destabilizing,uncertain,destabilizing,destabilizing,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P142I,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P142K,uncertain,neutral,uncertain,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P142L,uncertain,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P142M,uncertain,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P142N,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +P142Q,uncertain,neutral,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P142R,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P142S,uncertain,uncertain,uncertain,uncertain,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +P142V,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P142W,uncertain,uncertain,uncertain,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P142Y,uncertain,uncertain,uncertain,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V143A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V143C,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +V143D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V143E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V143F,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V143G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V143H,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V143K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V143N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V143P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V143Q,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V143R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V143S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V143T,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V143W,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V143Y,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +Q144C,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,damaging,"Long Range, Disulfide bridges" +Q144F,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q144I,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q144P,uncertain,uncertain,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Q144W,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L145A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145C,uncertain,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145H,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145K,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +L145N,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145Q,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145W,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L145Y,uncertain,uncertain,uncertain,uncertain,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +W146C,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,damaging,"Long Range, Disulfide bridges" +W146D,uncertain,uncertain,destabilizing,uncertain,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +W146E,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +W146K,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +W146N,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +W146P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +W146Q,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +W146R,neutral,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +V147D,uncertain,uncertain,destabilizing,neutral,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V147E,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V147F,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V147G,uncertain,uncertain,destabilizing,uncertain,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V147H,uncertain,uncertain,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V147K,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V147N,neutral,uncertain,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V147P,uncertain,uncertain,destabilizing,uncertain,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V147Q,neutral,neutral,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V147R,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V147S,neutral,uncertain,destabilizing,neutral,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V147W,uncertain,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V147Y,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +P151A,uncertain,uncertain,uncertain,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P151D,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +P151E,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P151F,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P151G,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P151H,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P151I,uncertain,uncertain,uncertain,destabilizing,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P151K,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P151M,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P151N,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +P151Q,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P151R,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P151W,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P151Y,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P152G,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G154F,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G154I,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G154K,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G154L,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G154M,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G154P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G154R,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G154V,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G154W,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +T155D,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,uncertain,neutral,neutral,neutral,Stability +T155E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,Stability +T155F,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,Stability +T155H,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,Stability +T155K,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,Stability +T155L,uncertain,uncertain,uncertain,destabilizing,neutral,,,,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,Stability +T155P,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,Stability +T155Q,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,Stability +T155R,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,Stability +T155W,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,Stability +T155Y,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,Stability +R156D,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R156E,neutral,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R156G,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R156N,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R156P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V157D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V157G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157H,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157N,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V157R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157W,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V157Y,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R158A,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R158C,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R158D,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R158E,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R158F,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +R158G,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R158H,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R158I,uncertain,uncertain,neutral,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R158L,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R158M,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R158N,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R158P,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R158Q,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R158S,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R158T,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R158V,uncertain,uncertain,neutral,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R158W,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +R158Y,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A159C,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A159D,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A159E,uncertain,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A159F,uncertain,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A159H,destabilizing,destabilizing,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A159I,neutral,neutral,stabilizing,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A159K,destabilizing,destabilizing,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A159L,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A159M,uncertain,uncertain,uncertain,neutral,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A159N,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A159P,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A159Q,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A159R,destabilizing,destabilizing,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A159W,destabilizing,destabilizing,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A159Y,uncertain,destabilizing,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M160A,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M160C,uncertain,uncertain,neutral,neutral,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M160D,uncertain,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M160E,uncertain,uncertain,neutral,neutral,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M160F,uncertain,uncertain,neutral,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M160G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M160H,uncertain,neutral,uncertain,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M160K,uncertain,uncertain,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M160N,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M160P,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M160Q,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M160R,neutral,neutral,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M160S,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M160W,uncertain,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M160Y,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +A161D,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161E,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161F,destabilizing,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161H,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161R,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161W,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A161Y,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162D,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162F,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162H,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162K,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +I162N,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162Q,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162W,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I162Y,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +Y163A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163C,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163H,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163I,neutral,uncertain,destabilizing,neutral,neutral,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163L,neutral,neutral,destabilizing,neutral,neutral,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163M,neutral,uncertain,destabilizing,neutral,neutral,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163N,uncertain,uncertain,destabilizing,destabilizing,destabilizing,neutral,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163P,uncertain,uncertain,destabilizing,uncertain,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163T,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163V,neutral,uncertain,destabilizing,neutral,uncertain,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y163W,uncertain,uncertain,neutral,destabilizing,uncertain,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +K164A,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K164C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K164D,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K164E,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K164G,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K164H,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K164M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K164N,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K164P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +K164Q,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K164S,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K164T,uncertain,neutral,neutral,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +K164V,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q165C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q165D,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q165P,uncertain,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q167C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q167F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q167I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q167W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Q167Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H168A,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H168C,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H168E,uncertain,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H168G,uncertain,uncertain,uncertain,neutral,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H168I,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H168K,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H168L,neutral,neutral,uncertain,neutral,neutral,neutral,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H168M,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H168P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +H168R,neutral,neutral,uncertain,neutral,neutral,neutral,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H168S,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H168T,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H168V,neutral,neutral,uncertain,neutral,neutral,neutral,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H168W,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M169C,neutral,uncertain,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M169D,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M169E,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M169G,uncertain,uncertain,neutral,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M169H,uncertain,uncertain,neutral,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M169N,uncertain,uncertain,neutral,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M169P,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M169Q,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M169S,neutral,uncertain,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M169T,neutral,neutral,neutral,neutral,neutral,neutral,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M169Y,uncertain,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +T170C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T170E,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T170F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T170H,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T170I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T170Q,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T170R,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T170W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T170Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +E171A,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +E171C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +E171G,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +E171N,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +E171P,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +E171S,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +E171T,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +V172A,neutral,neutral,uncertain,neutral,neutral,neutral,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V172C,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V172D,uncertain,uncertain,uncertain,uncertain,neutral,neutral,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V172E,uncertain,neutral,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V172F,destabilizing,uncertain,uncertain,destabilizing,uncertain,neutral,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V172G,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V172H,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V172K,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V172N,uncertain,neutral,uncertain,uncertain,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V172P,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V172R,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V172S,uncertain,uncertain,uncertain,neutral,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V172T,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V172W,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V172Y,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173A,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V173C,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V173D,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V173E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V173F,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V173H,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173M,uncertain,uncertain,uncertain,destabilizing,uncertain,neutral,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173N,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V173P,uncertain,uncertain,uncertain,uncertain,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V173Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V173R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173S,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V173T,uncertain,uncertain,uncertain,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V173W,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V173Y,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R174A,neutral,uncertain,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R174D,uncertain,uncertain,destabilizing,neutral,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R174E,neutral,uncertain,destabilizing,neutral,neutral,neutral,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R174F,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +R174G,neutral,uncertain,destabilizing,neutral,neutral,neutral,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R174I,neutral,neutral,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R174M,neutral,neutral,uncertain,neutral,neutral,neutral,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R174N,neutral,uncertain,destabilizing,neutral,neutral,neutral,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R174P,neutral,uncertain,destabilizing,neutral,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R174T,neutral,uncertain,uncertain,neutral,neutral,neutral,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R174V,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R174W,neutral,neutral,destabilizing,neutral,neutral,neutral,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +R174Y,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +R175A,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +R175C,neutral,uncertain,neutral,neutral,neutral,neutral,,neutral,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +R175D,destabilizing,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Stability, Long Range, Functional" +R175E,destabilizing,uncertain,neutral,destabilizing,uncertain,,,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Stability, Long Range, Functional" +R175F,uncertain,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +R175G,uncertain,uncertain,neutral,destabilizing,uncertain,neutral,,neutral,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Stability, Long Range, Functional" +R175H,uncertain,uncertain,neutral,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Stability, Long Range, Functional" +R175I,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +R175K,uncertain,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +R175L,neutral,neutral,neutral,neutral,neutral,neutral,,neutral,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +R175M,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +R175N,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +R175P,uncertain,uncertain,neutral,neutral,uncertain,neutral,,neutral,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +R175Q,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +R175S,uncertain,uncertain,neutral,uncertain,uncertain,neutral,,neutral,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +R175T,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +R175V,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +R175W,destabilizing,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +R175Y,destabilizing,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +C176A,uncertain,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176D,uncertain,uncertain,neutral,neutral,neutral,,,,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +C176E,uncertain,uncertain,uncertain,neutral,uncertain,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +C176F,uncertain,uncertain,neutral,destabilizing,destabilizing,uncertain,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176G,uncertain,uncertain,neutral,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176H,uncertain,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176I,destabilizing,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176K,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176L,destabilizing,uncertain,neutral,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176M,uncertain,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176N,uncertain,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176P,uncertain,destabilizing,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,"Stability, Functional" +C176Q,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176R,destabilizing,uncertain,neutral,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176S,uncertain,uncertain,neutral,uncertain,destabilizing,neutral,,neutral,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176T,uncertain,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176V,uncertain,uncertain,neutral,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176W,destabilizing,uncertain,neutral,destabilizing,destabilizing,uncertain,,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +C176Y,destabilizing,uncertain,neutral,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +P177A,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,damaging,neutral,neutral,Functional +P177C,uncertain,uncertain,neutral,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +P177D,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +P177E,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +P177F,uncertain,uncertain,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +P177G,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,damaging,neutral,neutral,Functional +P177H,uncertain,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +P177I,uncertain,uncertain,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +P177K,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +P177L,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +P177M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +P177N,uncertain,uncertain,neutral,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +P177Q,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +P177R,uncertain,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +P177T,uncertain,uncertain,neutral,uncertain,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +P177V,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +P177W,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +P177Y,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +H178C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +H178E,uncertain,neutral,neutral,stabilizing,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Stability, Long Range, Functional" +H178G,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +H178I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +H178L,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Local Int., Long Range, Functional" +H178P,uncertain,uncertain,neutral,neutral,neutral,neutral,uncertain,destabilizing,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Local Int., Long Range, Functional" +H179A,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179C,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,damaging,neutral,damaging,"Long Range, Functional, Disulfide bridges" +H179D,uncertain,neutral,uncertain,uncertain,neutral,neutral,,neutral,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +H179E,uncertain,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +H179F,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179G,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179I,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179K,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179L,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179M,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179N,uncertain,uncertain,neutral,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179R,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179S,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179T,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179V,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179W,uncertain,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +H179Y,uncertain,uncertain,neutral,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +E180A,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180F,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180G,neutral,neutral,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180H,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180K,neutral,neutral,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180L,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180N,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +E180R,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180S,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180T,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180V,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +E180W,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +E180Y,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +R181A,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +R181D,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +R181E,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +R181F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +R181G,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +R181H,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +R181I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +R181M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +R181P,uncertain,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +R181V,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +R181W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +R181Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +C182D,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +C182K,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +C182M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +C182P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,"Stability, Functional" +C182Q,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +C182W,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +D184F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D184I,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D184K,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D184L,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D184W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D186F,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D186I,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D186K,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D186L,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D186R,uncertain,neutral,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D186V,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D186W,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G187F,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G187H,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G187K,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G187L,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G187P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G187R,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G187W,uncertain,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G187Y,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L188D,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A189D,uncertain,neutral,uncertain,destabilizing,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189F,destabilizing,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189G,uncertain,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +A189H,uncertain,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189K,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189P,uncertain,uncertain,uncertain,destabilizing,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189Q,uncertain,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189R,destabilizing,uncertain,neutral,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189W,destabilizing,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +A189Y,destabilizing,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P190E,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P190F,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P190G,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +P190I,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P190K,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P190L,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P190M,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P190R,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P190T,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +P190V,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P190W,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P190Y,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P191F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P191I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P191L,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P191W,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P191Y,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193A,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193C,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193D,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193E,neutral,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193F,uncertain,uncertain,neutral,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193G,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193I,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193K,uncertain,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193L,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193M,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193N,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193P,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +H193Q,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193R,uncertain,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +H193S,uncertain,uncertain,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193T,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193V,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H193W,uncertain,uncertain,neutral,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +H193Y,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L194A,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +L194C,uncertain,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +L194D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +L194E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +L194F,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,Functional +L194G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +L194H,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +L194I,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +L194K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,"Stability, Functional" +L194M,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +L194N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +L194P,uncertain,uncertain,destabilizing,uncertain,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +L194Q,uncertain,uncertain,destabilizing,uncertain,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +L194R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +L194S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +L194T,uncertain,uncertain,destabilizing,uncertain,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +L194V,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +L194W,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +L194Y,uncertain,uncertain,uncertain,uncertain,destabilizing,,,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +I195A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195F,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +I195G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195H,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +I195N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195Q,uncertain,uncertain,destabilizing,uncertain,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +I195S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195T,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I195W,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +I195Y,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +R196A,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196C,neutral,uncertain,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196D,uncertain,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R196E,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196F,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +R196G,uncertain,uncertain,neutral,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196H,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196I,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196L,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196M,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196N,uncertain,neutral,neutral,uncertain,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R196Q,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196S,uncertain,uncertain,neutral,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196T,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196V,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R196W,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +R196Y,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V197A,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V197C,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V197D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V197E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V197F,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V197G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V197H,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V197K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V197N,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V197P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V197Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V197R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V197S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V197T,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +V197W,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V197Y,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +E198A,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +E198C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +E198D,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +E198F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E198G,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +E198H,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E198I,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E198K,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E198L,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E198M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E198N,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +E198P,uncertain,destabilizing,destabilizing,uncertain,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +E198Q,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E198R,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E198S,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +E198T,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +E198W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E198Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199A,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199D,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199E,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199F,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199H,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199I,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G199K,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199L,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199M,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199N,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G199Q,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199R,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199S,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199T,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199V,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G199W,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G199Y,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +N200A,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +N200C,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +N200E,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +N200F,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +N200K,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +N200L,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +N200M,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +N200P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +N200Q,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +N200R,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +N200V,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +N200W,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +N200Y,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +V203D,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V203E,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V203F,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V203H,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V203K,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V203M,uncertain,neutral,uncertain,uncertain,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V203N,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V203P,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V203Q,uncertain,neutral,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V203R,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V203W,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V203Y,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +E204P,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205C,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205H,uncertain,uncertain,uncertain,uncertain,uncertain,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y205I,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205L,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205M,uncertain,uncertain,destabilizing,uncertain,neutral,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205T,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205V,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y205W,uncertain,uncertain,neutral,destabilizing,uncertain,,,,uncertain,,,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +L206D,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +D207F,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +D207I,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +D207K,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +D207L,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +D207R,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +D207W,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +D207Y,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +D208A,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D208E,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D208F,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D208G,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +D208H,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D208I,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D208K,uncertain,neutral,destabilizing,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +D208L,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D208M,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D208P,uncertain,uncertain,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +D208Q,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D208R,uncertain,neutral,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D208S,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D208V,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D208W,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D208Y,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +T211C,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,stabilizing,neutral,neutral,neutral,"PTM, Long Range" +T211D,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,uncertain,neutral,neutral,neutral,PTM +T211E,neutral,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +T211F,neutral,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +T211G,uncertain,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,stabilizing,neutral,neutral,neutral,"Stability, PTM, Long Range" +T211H,uncertain,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +T211I,neutral,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +T211K,neutral,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +T211L,neutral,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +T211M,neutral,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +T211P,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,uncertain,neutral,neutral,neutral,"Stability, PTM" +T211Q,neutral,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +T211R,neutral,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +T211V,neutral,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +T211W,neutral,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,damaging,damaging,potentially_damaging,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +T211Y,neutral,neutral,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,uncertain,damaging,potentially_damaging,mixed_effects,neutral,neutral,neutral,"Stability, PTM, Long Range" +F212P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R213A,uncertain,uncertain,uncertain,neutral,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R213C,uncertain,uncertain,neutral,neutral,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R213D,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R213E,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R213F,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +R213G,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R213H,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R213I,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R213L,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R213M,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R213N,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R213P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R213Q,neutral,uncertain,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R213S,uncertain,uncertain,uncertain,uncertain,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R213T,uncertain,uncertain,uncertain,neutral,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R213V,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R213W,uncertain,uncertain,neutral,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +R213Y,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H214I,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H214L,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H214W,uncertain,uncertain,neutral,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +S215A,neutral,neutral,neutral,neutral,neutral,,,,uncertain,damaging,uncertain,uncertain,neutral,neutral,neutral,PTM +S215D,uncertain,uncertain,destabilizing,neutral,neutral,,,,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,Stability +S215G,neutral,neutral,uncertain,neutral,neutral,,,,uncertain,damaging,uncertain,stabilizing,neutral,neutral,neutral,"PTM, Long Range" +S215I,neutral,neutral,neutral,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +S215K,neutral,neutral,uncertain,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +S215L,neutral,neutral,neutral,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +S215P,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,Stability +S215T,neutral,neutral,neutral,neutral,neutral,,,,neutral,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +S215V,neutral,neutral,neutral,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +V216A,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +V216C,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +V216D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V216E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V216F,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V216G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V216H,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V216K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V216M,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V216N,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V216P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V216Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V216R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V216S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V216T,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V216W,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V216Y,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V217D,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V217E,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V217H,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V217K,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V217N,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V217P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V217Q,uncertain,neutral,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V217R,destabilizing,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +V218A,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V218C,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +V218D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V218E,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V218F,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V218G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V218H,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V218K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V218N,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V218P,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V218Q,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V218R,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V218S,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V218T,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +V218W,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V218Y,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P219G,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +Y220A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220C,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220H,uncertain,uncertain,destabilizing,uncertain,neutral,,,,uncertain,uncertain,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220I,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,uncertain,uncertain,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220K,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,uncertain,uncertain,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220L,uncertain,neutral,uncertain,neutral,neutral,,,,uncertain,damaging,uncertain,stabilizing,neutral,neutral,neutral,"PTM, Long Range" +Y220M,neutral,neutral,destabilizing,neutral,neutral,,,,uncertain,damaging,uncertain,stabilizing,neutral,neutral,neutral,"Stability, PTM, Long Range" +Y220N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220Q,uncertain,destabilizing,destabilizing,uncertain,destabilizing,,,,uncertain,neutral,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220R,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,uncertain,uncertain,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220T,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220V,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,uncertain,neutral,uncertain,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y220W,neutral,neutral,neutral,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +E221C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E221F,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E221G,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E221H,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E221I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E221K,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E221L,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E221M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E221N,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E221P,neutral,uncertain,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +E221R,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E221T,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E221W,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E221Y,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P222W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +P223D,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +P223F,neutral,neutral,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223G,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223H,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223I,uncertain,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223K,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223L,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223N,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +P223R,uncertain,uncertain,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223V,uncertain,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223W,uncertain,uncertain,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P223Y,uncertain,uncertain,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +E224C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E224F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E224G,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E224H,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E224I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E224K,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E224N,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E224P,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E224R,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E224S,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E224T,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E224W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E224Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V225C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V225D,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V225H,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V225K,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V225N,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V225R,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V225W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +V225Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226A,uncertain,uncertain,neutral,uncertain,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G226C,uncertain,uncertain,neutral,uncertain,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G226D,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226E,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226F,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226H,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226I,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G226K,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226L,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226M,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226N,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226P,uncertain,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G226Q,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226R,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226S,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226T,uncertain,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G226V,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G226W,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G226Y,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D228F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D228M,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +D228W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C229P,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +T230D,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,uncertain,,,uncertain,neutral,neutral,neutral,Stability +T230E,uncertain,neutral,destabilizing,neutral,neutral,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T230G,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +T230P,neutral,uncertain,destabilizing,neutral,destabilizing,,,,uncertain,,,uncertain,neutral,neutral,neutral,Stability +T231C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,destabilizing,neutral,neutral,neutral,Long Range +T231E,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T231F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T231G,uncertain,uncertain,destabilizing,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +T231H,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T231I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T231K,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T231Q,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T231R,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T231W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +T231Y,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +I232A,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +I232C,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +I232D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +I232E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +I232G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +I232H,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +I232K,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +I232N,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +I232P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +I232Q,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +I232R,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +I232S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +I232W,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +I232Y,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H233C,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H233D,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H233E,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H233G,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H233I,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H233K,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H233P,neutral,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H233R,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +H233T,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H233V,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +H233W,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +Y234A,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234C,destabilizing,destabilizing,neutral,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234E,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234G,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234H,uncertain,uncertain,uncertain,uncertain,uncertain,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y234I,uncertain,uncertain,neutral,uncertain,uncertain,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y234K,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234M,neutral,uncertain,neutral,neutral,neutral,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,Long Range +Y234N,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234Q,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234R,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234S,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234T,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234V,destabilizing,destabilizing,neutral,destabilizing,destabilizing,,,,uncertain,,,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +Y234W,neutral,neutral,neutral,neutral,neutral,,,,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +N235A,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +N235E,uncertain,uncertain,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +N235F,uncertain,uncertain,neutral,destabilizing,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +N235G,uncertain,uncertain,neutral,neutral,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +N235I,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +N235L,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +N235M,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +N235P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +N235Q,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +N235V,uncertain,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +N235W,uncertain,uncertain,neutral,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +N235Y,destabilizing,uncertain,neutral,destabilizing,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236C,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,neutral,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,neutral,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236H,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,neutral,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236I,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236L,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,,neutral,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236M,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,neutral,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,,neutral,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236T,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236V,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +Y236W,neutral,uncertain,neutral,neutral,neutral,,,,uncertain,,,stabilizing,neutral,neutral,neutral,Long Range +M237A,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +M237C,neutral,uncertain,neutral,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +M237D,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +M237E,uncertain,uncertain,neutral,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +M237F,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M237G,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +M237H,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +M237K,neutral,neutral,destabilizing,neutral,neutral,neutral,,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M237N,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +M237P,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +M237Q,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +M237R,neutral,neutral,destabilizing,neutral,neutral,neutral,,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +M237S,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +M237T,uncertain,uncertain,uncertain,neutral,neutral,neutral,,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +M237V,uncertain,uncertain,uncertain,neutral,uncertain,neutral,,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +M237W,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +M237Y,uncertain,uncertain,uncertain,uncertain,destabilizing,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +C238A,uncertain,uncertain,neutral,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238D,uncertain,uncertain,neutral,neutral,uncertain,,neutral,,neutral,neutral,neutral,uncertain,damaging,damaging,neutral,"Functional, Disulfide bridges" +C238E,uncertain,uncertain,neutral,neutral,uncertain,,neutral,,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Long Range, Functional, Disulfide bridges" +C238F,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238G,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238H,uncertain,uncertain,neutral,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238I,uncertain,uncertain,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238K,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238L,uncertain,uncertain,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238M,uncertain,uncertain,neutral,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238N,uncertain,uncertain,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,uncertain,damaging,damaging,neutral,"Stability, Functional, Disulfide bridges" +C238Q,uncertain,uncertain,neutral,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238R,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238S,uncertain,uncertain,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Long Range, Functional, Disulfide bridges" +C238T,uncertain,uncertain,neutral,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238V,uncertain,uncertain,neutral,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238W,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +C238Y,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,damaging,damaging,neutral,"Stability, Long Range, Functional, Disulfide bridges" +N239A,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,damaging,neutral,neutral,Functional +N239C,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,damaging,neutral,neutral,Functional +N239D,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +N239E,uncertain,neutral,neutral,stabilizing,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +N239F,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +N239G,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,damaging,neutral,neutral,Functional +N239H,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +N239I,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +N239K,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +N239L,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +N239M,neutral,neutral,neutral,neutral,neutral,uncertain,stabilizing,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Local Int., Long Range, Functional" +N239P,neutral,uncertain,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +N239Q,uncertain,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +N239R,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +N239T,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +N239V,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +N239W,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +N239Y,uncertain,neutral,uncertain,neutral,neutral,stabilizing,neutral,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Local Int., Long Range, Functional" +S240A,neutral,neutral,uncertain,neutral,neutral,,neutral,,uncertain,,,uncertain,damaging,neutral,neutral,Functional +S240C,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,,,neutral,damaging,neutral,neutral,Functional +S240D,neutral,neutral,neutral,neutral,neutral,,neutral,,uncertain,,,neutral,damaging,neutral,neutral,Functional +S240E,neutral,neutral,neutral,neutral,neutral,,neutral,,uncertain,,,neutral,damaging,neutral,neutral,Functional +S240F,neutral,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,uncertain,,,neutral,damaging,neutral,neutral,"Local Int., Functional" +S240G,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,uncertain,,,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +S240H,uncertain,uncertain,uncertain,neutral,neutral,,neutral,,uncertain,,,neutral,damaging,neutral,neutral,Functional +S240I,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,uncertain,,,neutral,damaging,neutral,neutral,Functional +S240K,uncertain,neutral,uncertain,neutral,neutral,,neutral,,uncertain,,,neutral,damaging,neutral,neutral,Functional +S240L,uncertain,uncertain,uncertain,neutral,uncertain,,neutral,,uncertain,,,neutral,damaging,neutral,neutral,Functional +S240M,neutral,neutral,uncertain,neutral,neutral,,neutral,,uncertain,,,neutral,damaging,neutral,neutral,Functional +S240N,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,,,neutral,damaging,neutral,neutral,Functional +S240P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,uncertain,,,neutral,damaging,neutral,neutral,"Stability, Functional" +S240Q,neutral,neutral,uncertain,neutral,neutral,,neutral,,uncertain,,,neutral,damaging,neutral,neutral,Functional +S240R,uncertain,neutral,uncertain,uncertain,neutral,uncertain,neutral,neutral,uncertain,,,neutral,damaging,neutral,neutral,Functional +S240T,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,,,neutral,damaging,neutral,neutral,Functional +S240V,neutral,neutral,uncertain,neutral,neutral,,neutral,,uncertain,,,neutral,damaging,neutral,neutral,Functional +S240W,uncertain,neutral,neutral,uncertain,neutral,,destabilizing,,uncertain,,,neutral,damaging,neutral,neutral,"Local Int., Functional" +S240Y,neutral,neutral,uncertain,neutral,neutral,,destabilizing,,uncertain,,,neutral,damaging,neutral,neutral,"Local Int., Functional" +S241D,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,uncertain,,,neutral,neutral,neutral,neutral,Local Int. +S241P,uncertain,neutral,uncertain,neutral,neutral,uncertain,destabilizing,neutral,uncertain,,,neutral,neutral,neutral,neutral,Local Int. +S241V,neutral,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,uncertain,,,neutral,neutral,neutral,neutral,Local Int. +C242A,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,mixed_effects,damaging,damaging,neutral,"Long Range, Functional, Disulfide bridges" +C242D,uncertain,neutral,neutral,stabilizing,neutral,,neutral,,neutral,neutral,neutral,uncertain,damaging,damaging,neutral,"Stability, Functional, Disulfide bridges" +C242E,uncertain,neutral,neutral,uncertain,neutral,,neutral,,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Functional, Disulfide bridges" +C242F,uncertain,uncertain,neutral,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Stability, Functional, Disulfide bridges" +C242G,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,mixed_effects,damaging,damaging,neutral,"Long Range, Functional, Disulfide bridges" +C242H,uncertain,uncertain,neutral,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Stability, Functional, Disulfide bridges" +C242I,uncertain,uncertain,neutral,uncertain,neutral,,neutral,,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Functional, Disulfide bridges" +C242K,uncertain,uncertain,uncertain,uncertain,neutral,,neutral,,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Functional, Disulfide bridges" +C242L,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Functional, Disulfide bridges" +C242M,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Functional, Disulfide bridges" +C242N,uncertain,uncertain,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Functional, Disulfide bridges" +C242P,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,uncertain,damaging,damaging,neutral,"Stability, Functional, Disulfide bridges" +C242Q,uncertain,uncertain,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Functional, Disulfide bridges" +C242R,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Functional, Disulfide bridges" +C242S,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,mixed_effects,damaging,damaging,neutral,"Long Range, Functional, Disulfide bridges" +C242T,uncertain,uncertain,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Functional, Disulfide bridges" +C242V,uncertain,uncertain,neutral,uncertain,neutral,,neutral,,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Functional, Disulfide bridges" +C242W,uncertain,uncertain,neutral,destabilizing,destabilizing,neutral,neutral,destabilizing,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Stability, Local Int., Functional, Disulfide bridges" +C242Y,uncertain,uncertain,neutral,destabilizing,destabilizing,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,damaging,damaging,neutral,"Stability, Functional, Disulfide bridges" +M243A,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243C,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243D,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243E,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243F,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243G,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243H,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243K,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243N,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243P,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243Q,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243R,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243S,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243T,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,destabilizing,neutral,neutral,neutral,destabilizing,damaging,neutral,neutral,"Local Int., Long Range, Functional" +M243W,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +M243Y,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Long Range, Functional" +G244A,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G244C,uncertain,uncertain,neutral,uncertain,uncertain,destabilizing,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +G244D,uncertain,uncertain,uncertain,neutral,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +G244E,uncertain,uncertain,uncertain,neutral,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +G244F,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G244H,uncertain,uncertain,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G244I,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G244K,uncertain,uncertain,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G244L,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G244M,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G244N,uncertain,uncertain,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G244P,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G244Q,uncertain,uncertain,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G244R,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G244S,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G244T,uncertain,uncertain,uncertain,destabilizing,destabilizing,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G244V,destabilizing,uncertain,uncertain,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Local Int., Long Range" +G244W,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G244Y,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G245A,destabilizing,uncertain,uncertain,destabilizing,uncertain,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245C,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,damaging,"Stability, Long Range, Functional, Disulfide bridges" +G245D,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,uncertain,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245E,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245F,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245H,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245I,uncertain,uncertain,destabilizing,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245K,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245L,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245M,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245N,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245Q,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245R,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245S,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245T,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245V,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245W,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +G245Y,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +M246A,uncertain,uncertain,neutral,uncertain,uncertain,,neutral,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +M246C,uncertain,uncertain,neutral,uncertain,uncertain,,neutral,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +M246D,uncertain,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Stability, Long Range, Functional" +M246E,uncertain,uncertain,uncertain,uncertain,uncertain,,neutral,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +M246F,uncertain,uncertain,neutral,uncertain,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +M246G,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Stability, Long Range, Functional" +M246H,uncertain,uncertain,uncertain,uncertain,destabilizing,,neutral,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Stability, Long Range, Functional" +M246K,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +M246L,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,Functional +M246N,uncertain,uncertain,uncertain,destabilizing,uncertain,,neutral,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Stability, Long Range, Functional" +M246P,uncertain,uncertain,uncertain,neutral,uncertain,,neutral,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +M246Q,uncertain,uncertain,uncertain,neutral,uncertain,,neutral,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +M246R,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +M246S,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Stability, Long Range, Functional" +M246T,uncertain,uncertain,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +M246V,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,mixed_effects,damaging,neutral,neutral,"Long Range, Functional" +M246W,uncertain,uncertain,neutral,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +M246Y,uncertain,uncertain,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,stabilizing,damaging,neutral,neutral,"Stability, Long Range, Functional" +N247D,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Local Int. +N247I,uncertain,neutral,uncertain,destabilizing,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +N247P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,neutral,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +N247T,uncertain,uncertain,uncertain,uncertain,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Local Int. +N247V,uncertain,neutral,uncertain,destabilizing,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R248A,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R248C,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Local Int., Long Range" +R248D,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R248E,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R248G,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Local Int., Long Range" +R248H,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R248I,uncertain,uncertain,neutral,destabilizing,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R248L,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Local Int., Long Range" +R248M,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R248N,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R248P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Local Int., Long Range" +R248Q,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R248S,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R248T,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R248V,uncertain,uncertain,neutral,destabilizing,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R249A,uncertain,uncertain,neutral,uncertain,neutral,,neutral,,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249C,neutral,neutral,neutral,neutral,neutral,,neutral,,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249D,uncertain,uncertain,uncertain,uncertain,uncertain,,neutral,,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249E,uncertain,uncertain,neutral,uncertain,uncertain,,neutral,,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249F,neutral,neutral,neutral,neutral,neutral,,neutral,,uncertain,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R249G,destabilizing,uncertain,uncertain,destabilizing,destabilizing,uncertain,neutral,neutral,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R249H,uncertain,uncertain,neutral,neutral,neutral,,neutral,,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249I,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249L,neutral,neutral,neutral,neutral,neutral,,neutral,,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249M,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249N,uncertain,uncertain,neutral,uncertain,neutral,,neutral,,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R249Q,uncertain,uncertain,neutral,neutral,neutral,,neutral,,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249S,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249T,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249V,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R249W,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R249Y,neutral,neutral,neutral,neutral,neutral,,neutral,,uncertain,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +P250G,uncertain,uncertain,neutral,uncertain,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +P250S,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +I251A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I251C,uncertain,uncertain,uncertain,uncertain,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I251D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I251E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I251F,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I251G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I251H,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I251K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +I251N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I251P,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I251Q,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I251R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I251S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I251T,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I251W,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I251Y,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L252D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L252G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L252H,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L252P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L252S,uncertain,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +T253D,uncertain,uncertain,destabilizing,neutral,neutral,,,,uncertain,,,uncertain,neutral,neutral,neutral,Stability +T253E,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T253F,uncertain,uncertain,neutral,uncertain,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T253G,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T253H,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T253K,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T253P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,uncertain,,,uncertain,neutral,neutral,neutral,Stability +T253R,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T253W,uncertain,destabilizing,neutral,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T253Y,destabilizing,uncertain,neutral,destabilizing,destabilizing,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +I254A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254H,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +I254N,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254Q,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254R,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254T,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254W,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I254Y,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I255A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I255C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I255D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I255E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I255F,uncertain,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I255G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I255H,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I255K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +I255N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I255P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I255Q,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I255R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I255S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +I255W,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +I255Y,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +T256G,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,uncertain,,,neutral,neutral,neutral,neutral,Stability +T256P,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,uncertain,,,uncertain,neutral,neutral,neutral,Stability +L257A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257C,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257F,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257H,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +L257N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257Q,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257T,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257W,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L257Y,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +E258D,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +E258G,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +E258K,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +E258N,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +E258P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +E258R,neutral,neutral,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +E258W,uncertain,uncertain,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259C,uncertain,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +D259F,uncertain,uncertain,destabilizing,destabilizing,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259I,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259K,uncertain,neutral,destabilizing,destabilizing,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259L,uncertain,neutral,destabilizing,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +D259Q,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259R,uncertain,neutral,destabilizing,destabilizing,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259V,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +D259W,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +S261P,uncertain,uncertain,destabilizing,destabilizing,neutral,uncertain,uncertain,uncertain,uncertain,,,neutral,neutral,neutral,neutral,Stability +G262A,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262C,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262D,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262E,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262F,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262H,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262I,destabilizing,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G262K,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262L,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262M,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262N,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G262Q,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262R,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262S,uncertain,uncertain,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262T,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262V,destabilizing,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +G262W,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +G262Y,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +N263P,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +L264F,neutral,neutral,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L264G,uncertain,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L264R,uncertain,neutral,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L264W,uncertain,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L264Y,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +L265A,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265D,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265E,uncertain,uncertain,destabilizing,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265H,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265K,uncertain,uncertain,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +L265N,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265Q,uncertain,neutral,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265R,uncertain,neutral,destabilizing,uncertain,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265T,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +L265W,uncertain,uncertain,uncertain,destabilizing,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266C,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266D,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266E,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266F,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266H,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266I,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266L,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266M,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266N,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266Q,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266R,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266S,destabilizing,uncertain,uncertain,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266T,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266V,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266W,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G266Y,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R267A,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R267C,neutral,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R267D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R267E,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R267F,uncertain,uncertain,neutral,destabilizing,neutral,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R267G,uncertain,uncertain,destabilizing,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R267H,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R267I,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R267L,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R267M,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R267N,neutral,uncertain,destabilizing,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R267P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +R267Q,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R267S,neutral,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R267T,neutral,neutral,uncertain,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R267V,neutral,neutral,neutral,neutral,neutral,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +R267W,uncertain,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R267Y,destabilizing,uncertain,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +N268P,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +S269D,neutral,neutral,uncertain,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +S269E,uncertain,neutral,neutral,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +S269F,neutral,neutral,neutral,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +S269H,neutral,neutral,neutral,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +S269K,uncertain,neutral,neutral,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +S269P,uncertain,uncertain,uncertain,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +S269R,neutral,neutral,neutral,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +S269W,neutral,neutral,neutral,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +S269Y,neutral,neutral,neutral,neutral,neutral,,,,uncertain,damaging,uncertain,neutral,neutral,neutral,neutral,PTM +F270A,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270D,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270H,uncertain,uncertain,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270I,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +F270K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270L,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +F270M,uncertain,uncertain,uncertain,uncertain,uncertain,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +F270N,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270T,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270V,uncertain,destabilizing,uncertain,destabilizing,destabilizing,,,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,"Stability, Long Range" +F270W,uncertain,uncertain,uncertain,neutral,neutral,,,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E271W,uncertain,uncertain,neutral,destabilizing,uncertain,,,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V272D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V272E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V272F,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V272H,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V272K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V272N,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V272P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V272Q,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +V272R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V272S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +V272W,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +V272Y,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R273A,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R273C,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R273D,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R273E,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R273G,uncertain,uncertain,destabilizing,uncertain,uncertain,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R273H,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Local Int., Long Range" +R273I,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R273L,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R273M,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R273N,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R273P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Local Int., Long Range" +R273Q,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R273S,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R273T,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R273V,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R273W,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +V274A,uncertain,uncertain,destabilizing,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +V274C,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,neutral,neutral,Functional +V274D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +V274E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,"Stability, Functional" +V274F,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +V274G,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +V274H,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +V274K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +V274L,uncertain,uncertain,uncertain,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,damaging,neutral,neutral,Functional +V274M,neutral,neutral,uncertain,neutral,neutral,,neutral,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,Functional +V274N,uncertain,uncertain,destabilizing,uncertain,uncertain,,neutral,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +V274P,uncertain,uncertain,destabilizing,uncertain,destabilizing,,neutral,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +V274Q,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,uncertain,damaging,neutral,neutral,"Stability, Functional" +V274R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +V274S,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +V274T,neutral,uncertain,destabilizing,neutral,neutral,,neutral,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +V274W,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +V274Y,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,damaging,neutral,neutral,"Stability, Functional" +C275A,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +C275E,neutral,neutral,uncertain,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C275F,uncertain,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C275G,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +C275H,uncertain,neutral,uncertain,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C275I,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C275K,uncertain,uncertain,uncertain,uncertain,neutral,,destabilizing,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +C275L,uncertain,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C275M,uncertain,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C275N,uncertain,uncertain,uncertain,uncertain,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C275P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +C275Q,uncertain,neutral,uncertain,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C275R,uncertain,neutral,uncertain,uncertain,neutral,uncertain,destabilizing,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +C275S,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,mixed_effects,neutral,neutral,neutral,Long Range +C275T,neutral,neutral,neutral,neutral,neutral,,destabilizing,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +C275V,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C275W,uncertain,uncertain,uncertain,neutral,neutral,uncertain,destabilizing,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +C275Y,neutral,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Local Int., Long Range" +A276C,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,damaging,Disulfide bridges +A276F,neutral,neutral,neutral,neutral,neutral,uncertain,stabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +A276G,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +A276K,neutral,neutral,neutral,neutral,neutral,uncertain,stabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +A276M,neutral,neutral,neutral,neutral,neutral,uncertain,stabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +A276P,neutral,neutral,neutral,neutral,neutral,destabilizing,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +C277A,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C277D,neutral,neutral,neutral,neutral,neutral,uncertain,stabilizing,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Local Int. +C277E,neutral,neutral,neutral,neutral,neutral,uncertain,stabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +C277F,neutral,neutral,neutral,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +C277G,uncertain,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C277H,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +C277K,neutral,neutral,uncertain,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +C277P,uncertain,uncertain,destabilizing,destabilizing,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +C277R,neutral,neutral,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +C277S,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +C277W,neutral,neutral,neutral,neutral,neutral,neutral,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +C277Y,neutral,neutral,neutral,neutral,neutral,neutral,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +P278A,uncertain,uncertain,destabilizing,neutral,neutral,neutral,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +P278C,destabilizing,uncertain,uncertain,destabilizing,uncertain,,neutral,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +P278D,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +P278E,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278F,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278G,destabilizing,uncertain,destabilizing,destabilizing,uncertain,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +P278H,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278I,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278K,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278L,destabilizing,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278M,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278N,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +P278Q,destabilizing,uncertain,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278R,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278S,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +P278T,destabilizing,uncertain,destabilizing,destabilizing,uncertain,neutral,neutral,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability +P278V,destabilizing,uncertain,destabilizing,destabilizing,uncertain,neutral,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278W,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +P278Y,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279A,uncertain,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279C,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279D,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279E,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279F,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279H,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,destabilizing,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,"Stability, Local Int." +G279I,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279K,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279L,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279M,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279N,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279Q,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279R,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279S,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279T,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279V,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +G279W,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,destabilizing,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,"Stability, Local Int." +G279Y,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R280A,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280C,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280D,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280E,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280F,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280G,uncertain,neutral,uncertain,neutral,neutral,destabilizing,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280H,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280I,neutral,neutral,neutral,neutral,neutral,destabilizing,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280K,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Local Int. +R280L,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280M,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280N,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280P,uncertain,uncertain,uncertain,neutral,neutral,destabilizing,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280Q,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280S,neutral,neutral,neutral,neutral,neutral,destabilizing,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280T,neutral,neutral,neutral,neutral,neutral,destabilizing,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280V,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280W,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R280Y,neutral,neutral,neutral,neutral,neutral,uncertain,destabilizing,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +D281A,neutral,neutral,neutral,neutral,neutral,neutral,destabilizing,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Local Int., Long Range" +D281C,uncertain,neutral,neutral,neutral,neutral,,destabilizing,,neutral,neutral,neutral,uncertain,neutral,neutral,damaging,"Local Int., Disulfide bridges" +D281G,uncertain,uncertain,uncertain,uncertain,neutral,neutral,destabilizing,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Local Int., Long Range" +D281I,neutral,neutral,neutral,neutral,neutral,,destabilizing,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +D281K,uncertain,neutral,uncertain,neutral,neutral,,destabilizing,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +D281P,uncertain,uncertain,uncertain,destabilizing,destabilizing,destabilizing,destabilizing,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,"Stability, Local Int." +D281R,uncertain,neutral,uncertain,uncertain,neutral,neutral,destabilizing,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +D281S,uncertain,neutral,neutral,neutral,neutral,,destabilizing,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Local Int., Long Range" +D281T,uncertain,neutral,uncertain,neutral,neutral,,destabilizing,,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Local Int. +D281V,neutral,neutral,neutral,neutral,neutral,neutral,destabilizing,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +D281Y,neutral,neutral,uncertain,neutral,neutral,neutral,destabilizing,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Local Int. +R282A,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R282C,uncertain,uncertain,neutral,neutral,uncertain,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R282D,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R282E,uncertain,uncertain,uncertain,uncertain,uncertain,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R282G,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R282H,uncertain,uncertain,neutral,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R282I,uncertain,uncertain,neutral,uncertain,neutral,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R282L,neutral,neutral,neutral,neutral,neutral,neutral,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R282M,neutral,neutral,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R282N,uncertain,uncertain,uncertain,uncertain,uncertain,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R282P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +R282Q,uncertain,uncertain,neutral,neutral,uncertain,neutral,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R282S,uncertain,uncertain,uncertain,uncertain,uncertain,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R282T,neutral,uncertain,uncertain,neutral,neutral,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R282V,uncertain,uncertain,neutral,neutral,neutral,,neutral,,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +R282W,uncertain,uncertain,neutral,destabilizing,destabilizing,neutral,neutral,,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +R283P,uncertain,uncertain,destabilizing,destabilizing,destabilizing,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,neutral,neutral,neutral,Stability +T284D,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,damaging,neutral,potentially_damaging,uncertain,neutral,neutral,neutral,PTM +T284E,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,damaging,neutral,potentially_damaging,neutral,neutral,neutral,neutral,PTM +T284F,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,damaging,neutral,potentially_damaging,neutral,neutral,neutral,neutral,PTM +T284K,neutral,neutral,neutral,neutral,neutral,neutral,neutral,uncertain,damaging,neutral,potentially_damaging,neutral,neutral,neutral,neutral,PTM +T284P,uncertain,uncertain,uncertain,destabilizing,destabilizing,neutral,neutral,uncertain,damaging,neutral,potentially_damaging,uncertain,neutral,neutral,neutral,"Stability, PTM" +T284R,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,damaging,neutral,potentially_damaging,neutral,neutral,neutral,neutral,PTM +T284W,neutral,neutral,neutral,neutral,neutral,uncertain,neutral,uncertain,damaging,neutral,potentially_damaging,neutral,neutral,neutral,neutral,PTM +E285C,neutral,uncertain,neutral,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E285G,neutral,uncertain,uncertain,neutral,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E285N,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E285P,destabilizing,destabilizing,destabilizing,destabilizing,destabilizing,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +E285T,neutral,neutral,uncertain,neutral,neutral,uncertain,neutral,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,Long Range +E286A,uncertain,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +E286C,uncertain,uncertain,neutral,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +E286G,destabilizing,uncertain,uncertain,destabilizing,uncertain,neutral,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +E286N,neutral,neutral,uncertain,neutral,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +E286P,uncertain,destabilizing,uncertain,stabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,"Stability, Long Range" +E286S,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +E286T,uncertain,uncertain,uncertain,uncertain,neutral,uncertain,uncertain,uncertain,neutral,neutral,neutral,destabilizing,neutral,neutral,neutral,Long Range +E287P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,uncertain,uncertain,neutral,neutral,neutral,stabilizing,neutral,neutral,neutral,"Stability, Long Range" +N288P,destabilizing,destabilizing,uncertain,destabilizing,destabilizing,uncertain,neutral,uncertain,neutral,neutral,neutral,uncertain,neutral,neutral,neutral,Stability