diff --git a/README.md b/README.md
index c3d6406..48eecb2 100644
--- a/README.md
+++ b/README.md
@@ -421,7 +421,7 @@ npx --yes @eshen_fox_mie/agent-ready ci --write
 
 Current detectors cover common JavaScript/TypeScript, Python, Ruby, PHP, C#, Java, Kotlin, Rust, Go, and monorepo repositories:
 
-- package manager: npm, pnpm, yarn, bun, pip, bundler, composer, dotnet, maven, gradle, cargo, go
+- package manager: npm, pnpm, yarn, bun, Python/pip, Poetry, PDM, uv, bundler, composer, dotnet, maven, gradle, cargo, go
 - commands: install, dev, start, build, test, lint, format, backend install, local services
 - docs: README, architecture docs, ADR directories, existing agent docs
 - CI: GitHub Actions workflows
diff --git a/docs/detectors.md b/docs/detectors.md
index 85f9eb8..2d0869a 100644
--- a/docs/detectors.md
+++ b/docs/detectors.md
@@ -9,7 +9,7 @@ This page summarizes the current detector coverage. Claims here should stay alig
 | Ecosystem | Detected signals | Frameworks/tools | Inferred commands |
 | --- | --- | --- | --- |
 | JavaScript / TypeScript | `package.json`, lockfiles, package scripts, framework configs, route/component conventions | React, Vite, Next.js, Next.js App Router, Vue, Nuxt, Astro, Svelte, SvelteKit, Express, NestJS, Vitest, Jest, Playwright, Storybook | package manager install, `dev`, `start`, `build`, `test`, `lint`, `format` from scripts |
-| Python | `pyproject.toml`, `requirements.txt`, `setup.py`, `tests/` | FastAPI, Django, Flask, Pytest, Ruff | `python3 -m pip install ...`, `python3 -m pytest`, Ruff lint/format |
+| Python | `pyproject.toml`, `requirements.txt`, `setup.py`, `poetry.lock`, `pdm.lock`, `uv.lock`, `tests/` | FastAPI, Django, Flask, Pytest, Ruff | pip, Poetry, PDM, or uv install/test commands plus Ruff lint/format |
 | Ruby | `Gemfile`, `config/application.rb`, `bin/rails` | Rails | `bundle install`, `bin/rails server`, `bin/rails test` |
 | PHP | `composer.json`, `artisan`, `app/Http/Kernel.php` | Laravel | `composer install`, `php artisan serve`, `php artisan test` |
 | C# / .NET | `*.csproj`, `*.sln`, `global.json`, `Program.cs` | .NET | `dotnet restore`, `dotnet build`, `dotnet test` |
diff --git a/src/scanner.mjs b/src/scanner.mjs
index 0dab02e..142789f 100644
--- a/src/scanner.mjs
+++ b/src/scanner.mjs
@@ -133,12 +133,19 @@ async function detectPackageManager(root, files = []) {
     ["bun", "bun.lockb"],
     ["bun", "bun.lock"],
     ["npm", "package-lock.json"],
+    ["poetry", "poetry.lock"],
+    ["pdm", "pdm.lock"],
+    ["uv", "uv.lock"],
   ];
   for (const [name, file] of checks) {
     if (await pathExists(path.join(root, file))) return name;
   }
   if (await pathExists(path.join(root, "package.json"))) return "npm";
-  if (await pathExists(path.join(root, "pyproject.toml"))) return "python";
+  const pyproject = await readTextIfExists(path.join(root, "pyproject.toml"));
+  if (hasPythonToolConfig(pyproject, "poetry")) return "poetry";
+  if (hasPythonToolConfig(pyproject, "pdm")) return "pdm";
+  if (hasPythonToolConfig(pyproject, "uv")) return "uv";
+  if (pyproject) return "python";
   if (await pathExists(path.join(root, "Cargo.toml"))) return "cargo";
   if (await pathExists(path.join(root, "go.mod"))) return "go";
   if (await pathExists(path.join(root, "mvnw")) || await pathExists(path.join(root, "pom.xml"))) return "maven";
@@ -164,13 +171,13 @@ async function detectCommands({ root, packageJson, packageManager, pyproject, ca
   }
 
   if (pyproject || files.includes("requirements.txt") || files.includes("setup.py")) {
-    commands.install ||= pyproject ? "python3 -m pip install -e ." : "python3 -m pip install -r requirements.txt";
+    commands.install ||= pythonInstallCommand(packageManager, Boolean(pyproject));
     if (hasPythonTool(pyproject, "pytest") || files.some((file) => /^tests?\//.test(file))) {
-      commands.test ||= "python3 -m pytest";
+      commands.test ||= pythonRunCommand(packageManager, "pytest");
     }
     if (hasPythonTool(pyproject, "ruff")) {
-      commands.lint ||= "python3 -m ruff check .";
-      commands.format ||= "python3 -m ruff format .";
+      commands.lint ||= pythonRunCommand(packageManager, "ruff check .");
+      commands.format ||= pythonRunCommand(packageManager, "ruff format .");
     }
   }
 
@@ -252,11 +259,30 @@ function runScriptCommand(packageManager, script) {
   return `npm run ${script}`;
 }
 
+function pythonInstallCommand(packageManager, hasPyproject) {
+  if (packageManager === "poetry") return "poetry install";
+  if (packageManager === "pdm") return "pdm install";
+  if (packageManager === "uv") return "uv sync";
+  return hasPyproject ? "python3 -m pip install -e ." : "python3 -m pip install -r requirements.txt";
+}
+
+function pythonRunCommand(packageManager, command) {
+  if (packageManager === "poetry") return `poetry run ${command}`;
+  if (packageManager === "pdm") return `pdm run ${command}`;
+  if (packageManager === "uv") return `uv run ${command}`;
+  return `python3 -m ${command}`;
+}
+
 function hasPythonTool(pyproject, tool) {
   if (!pyproject) return false;
   return new RegExp(`(^|[^a-zA-Z0-9_-])${escapeRegExp(tool)}([^a-zA-Z0-9_-]|$)`, "i").test(pyproject);
 }
 
+function hasPythonToolConfig(pyproject, tool) {
+  if (!pyproject) return false;
+  return new RegExp(`^\\s*\\[tool\\.${escapeRegExp(tool)}(?:\\.|\\])`, "im").test(pyproject);
+}
+
 function detectName({ packageJson, pyproject, cargoToml, goMod, pomXml, composerJson, files, root }) {
   if (packageJson?.name) return packageJson.name;
   const pyName = parseTomlValue(pyproject, "name");
diff --git a/test/fixtures/pdm-python-app/app/main.py b/test/fixtures/pdm-python-app/app/main.py
new file mode 100644
index 0000000..14c1ce9
--- /dev/null
+++ b/test/fixtures/pdm-python-app/app/main.py
@@ -0,0 +1,3 @@
+def hello():
+    return "pdm"
+
diff --git a/test/fixtures/pdm-python-app/pdm.lock b/test/fixtures/pdm-python-app/pdm.lock
new file mode 100644
index 0000000..919a901
--- /dev/null
+++ b/test/fixtures/pdm-python-app/pdm.lock
@@ -0,0 +1,2 @@
+# fixture lockfile
+
diff --git a/test/fixtures/pdm-python-app/pyproject.toml b/test/fixtures/pdm-python-app/pyproject.toml
new file mode 100644
index 0000000..dfec2c1
--- /dev/null
+++ b/test/fixtures/pdm-python-app/pyproject.toml
@@ -0,0 +1,11 @@
+[project]
+name = "fixture-pdm-python-app"
+version = "0.1.0"
+dependencies = ["flask"]
+
+[dependency-groups]
+dev = ["pytest", "ruff"]
+
+[tool.pdm]
+distribution = false
+
diff --git a/test/fixtures/pdm-python-app/tests/test_main.py b/test/fixtures/pdm-python-app/tests/test_main.py
new file mode 100644
index 0000000..053dc48
--- /dev/null
+++ b/test/fixtures/pdm-python-app/tests/test_main.py
@@ -0,0 +1,6 @@
+from app.main import hello
+
+
+def test_hello():
+    assert hello() == "pdm"
+
diff --git a/test/fixtures/poetry-python-app/app/main.py b/test/fixtures/poetry-python-app/app/main.py
new file mode 100644
index 0000000..798d1dc
--- /dev/null
+++ b/test/fixtures/poetry-python-app/app/main.py
@@ -0,0 +1,3 @@
+def hello():
+    return "poetry"
+
diff --git a/test/fixtures/poetry-python-app/poetry.lock b/test/fixtures/poetry-python-app/poetry.lock
new file mode 100644
index 0000000..919a901
--- /dev/null
+++ b/test/fixtures/poetry-python-app/poetry.lock
@@ -0,0 +1,2 @@
+# fixture lockfile
+
diff --git a/test/fixtures/poetry-python-app/pyproject.toml b/test/fixtures/poetry-python-app/pyproject.toml
new file mode 100644
index 0000000..5b9be1e
--- /dev/null
+++ b/test/fixtures/poetry-python-app/pyproject.toml
@@ -0,0 +1,14 @@
+[tool.poetry]
+name = "fixture-poetry-python-app"
+version = "0.1.0"
+description = "Fixture for Poetry package manager detection."
+authors = ["Fixture <fixture@example.com>"]
+
+[tool.poetry.dependencies]
+python = "^3.11"
+fastapi = "^0.115.0"
+
+[tool.poetry.group.dev.dependencies]
+pytest = "^8.0.0"
+ruff = "^0.8.0"
+
diff --git a/test/fixtures/poetry-python-app/tests/test_main.py b/test/fixtures/poetry-python-app/tests/test_main.py
new file mode 100644
index 0000000..b0d3968
--- /dev/null
+++ b/test/fixtures/poetry-python-app/tests/test_main.py
@@ -0,0 +1,6 @@
+from app.main import hello
+
+
+def test_hello():
+    assert hello() == "poetry"
+
diff --git a/test/fixtures/uv-python-app/app/main.py b/test/fixtures/uv-python-app/app/main.py
new file mode 100644
index 0000000..6471d3a
--- /dev/null
+++ b/test/fixtures/uv-python-app/app/main.py
@@ -0,0 +1,3 @@
+def hello():
+    return "uv"
+
diff --git a/test/fixtures/uv-python-app/pyproject.toml b/test/fixtures/uv-python-app/pyproject.toml
new file mode 100644
index 0000000..2ce8345
--- /dev/null
+++ b/test/fixtures/uv-python-app/pyproject.toml
@@ -0,0 +1,11 @@
+[project]
+name = "fixture-uv-python-app"
+version = "0.1.0"
+dependencies = ["django"]
+
+[dependency-groups]
+dev = ["pytest", "ruff"]
+
+[tool.uv]
+package = true
+
diff --git a/test/fixtures/uv-python-app/tests/test_main.py b/test/fixtures/uv-python-app/tests/test_main.py
new file mode 100644
index 0000000..4ea1e72
--- /dev/null
+++ b/test/fixtures/uv-python-app/tests/test_main.py
@@ -0,0 +1,6 @@
+from app.main import hello
+
+
+def test_hello():
+    assert hello() == "uv"
+
diff --git a/test/fixtures/uv-python-app/uv.lock b/test/fixtures/uv-python-app/uv.lock
new file mode 100644
index 0000000..919a901
--- /dev/null
+++ b/test/fixtures/uv-python-app/uv.lock
@@ -0,0 +1,2 @@
+# fixture lockfile
+
diff --git a/test/scanner.test.mjs b/test/scanner.test.mjs
index 1b11830..e8a442a 100644
--- a/test/scanner.test.mjs
+++ b/test/scanner.test.mjs
@@ -51,6 +51,28 @@ test("scan detects Python, Rust, and Go repositories", async () => {
   assert.equal(go.commands.test, "go test ./...");
 });
 
+test("scan detects Python package managers", async () => {
+  const poetry = await scanRepo(fixture("poetry-python-app"));
+  const pdm = await scanRepo(fixture("pdm-python-app"));
+  const uv = await scanRepo(fixture("uv-python-app"));
+
+  assert.equal(poetry.packageManager, "poetry");
+  assert.equal(poetry.commands.install, "poetry install");
+  assert.equal(poetry.commands.test, "poetry run pytest");
+  assert.equal(poetry.commands.lint, "poetry run ruff check .");
+  assert.equal(poetry.commands.format, "poetry run ruff format .");
+
+  assert.equal(pdm.packageManager, "pdm");
+  assert.equal(pdm.commands.install, "pdm install");
+  assert.equal(pdm.commands.test, "pdm run pytest");
+  assert.equal(pdm.commands.lint, "pdm run ruff check .");
+
+  assert.equal(uv.packageManager, "uv");
+  assert.equal(uv.commands.install, "uv sync");
+  assert.equal(uv.commands.test, "uv run pytest");
+  assert.equal(uv.commands.lint, "uv run ruff check .");
+});
+
 test("scan handles Go and Rust web framework edge cases", async () => {
   const goGin = await scanRepo(fixture("go-gin-cmd-app"));
   const rustWorkspace = await scanRepo(fixture("rust-workspace-web"));