diff --git a/API-INTERNAL.md b/API-INTERNAL.md
index c84d29afb..b5a9f55be 100644
--- a/API-INTERNAL.md
+++ b/API-INTERNAL.md
@@ -83,6 +83,7 @@ If the requested key is a collection, it will return an object with all the coll
 <ul>
 <li>Storage capacity errors: evicts data and retries the operation</li>
 <li>Invalid data errors: logs an alert and throws an error</li>
+<li>Non-retriable errors: logs an alert and resolves without retrying</li>
 <li>Other errors: retries the operation</li>
 </ul>
 </dd>
@@ -323,6 +324,7 @@ Remove a key from Onyx and update the subscribers
 Handles storage operation failures based on the error type:
 - Storage capacity errors: evicts data and retries the operation
 - Invalid data errors: logs an alert and throws an error
+- Non-retriable errors: logs an alert and resolves without retrying
 - Other errors: retries the operation
 
 **Kind**: global function  
diff --git a/lib/OnyxUtils.ts b/lib/OnyxUtils.ts
index 56dbb10fb..0c5f764f3 100644
--- a/lib/OnyxUtils.ts
+++ b/lib/OnyxUtils.ts
@@ -61,6 +61,14 @@ const SQLITE_STORAGE_ERRORS = [
 
 const STORAGE_ERRORS = [...IDB_STORAGE_ERRORS, ...SQLITE_STORAGE_ERRORS];
 
+// IndexedDB errors where retrying is futile because the underlying connection/store is broken.
+// The healing path (separate from retryOperation) is responsible for recovery.
+const IDB_NON_RETRIABLE_ERRORS = [
+    'internal error opening backing store', // LevelDB backing store is broken at the filesystem level
+] as const;
+
+const NON_RETRIABLE_ERRORS = [...IDB_NON_RETRIABLE_ERRORS];
+
 // Max number of retries for failed storage operations
 const MAX_STORAGE_OPERATION_RETRY_ATTEMPTS = 5;
 
@@ -786,6 +794,7 @@ function reportStorageQuota(error?: Error): Promise<void> {
  * Handles storage operation failures based on the error type:
  * - Storage capacity errors: evicts data and retries the operation
  * - Invalid data errors: logs an alert and throws an error
+ * - Non-retriable errors: logs an alert and resolves without retrying
  * - Other errors: retries the operation
  */
 function retryOperation<TMethod extends RetriableOnyxOperation>(error: Error, onyxMethod: TMethod, defaultParams: Parameters<TMethod>[0], retryAttempt: number | undefined): Promise<void> {
@@ -802,6 +811,12 @@ function retryOperation<TMethod extends RetriableOnyxOperation>(error: Error, on
     const errorMessage = error?.message?.toLowerCase?.();
     const errorName = error?.name?.toLowerCase?.();
     const isStorageCapacityError = STORAGE_ERRORS.some((storageError) => errorName?.includes(storageError) || errorMessage?.includes(storageError));
+    const isNonRetriableError = NON_RETRIABLE_ERRORS.some((nonRetriableError) => errorName?.includes(nonRetriableError) || errorMessage?.includes(nonRetriableError));
+
+    if (isNonRetriableError) {
+        Logger.logAlert(`Storage operation skipped retry for non-retriable error. Error: ${error}. onyxMethod: ${onyxMethod.name}.`);
+        return Promise.resolve();
+    }
 
     if (nextRetryAttempt > MAX_STORAGE_OPERATION_RETRY_ATTEMPTS) {
         Logger.logAlert(`Storage operation failed after 5 retries. Error: ${error}. onyxMethod: ${onyxMethod.name}.`);
diff --git a/tests/unit/onyxUtilsTest.ts b/tests/unit/onyxUtilsTest.ts
index cc1568365..dcd2f0b77 100644
--- a/tests/unit/onyxUtilsTest.ts
+++ b/tests/unit/onyxUtilsTest.ts
@@ -788,6 +788,7 @@ describe('OnyxUtils', () => {
         const genericError = new Error('Generic storage error');
         const invalidDataError = new Error("Failed to execute 'put' on 'IDBObjectStore': invalid data");
         const diskFullError = new Error('database or disk is full');
+        const nonRetriableIdbError = Object.assign(new Error('Internal error opening backing store for indexedDB.open.'), {name: 'UnknownError'});
 
         it('should retry only one time if the operation is firstly failed and then passed', async () => {
             StorageMock.setItem = jest.fn(StorageMock.setItem).mockRejectedValueOnce(genericError).mockImplementation(StorageMock.setItem);
@@ -822,6 +823,26 @@ describe('OnyxUtils', () => {
             expect(retryOperationSpy).toHaveBeenCalledTimes(1);
         });
 
+        it('should not retry for non-retriable IndexedDB backing-store errors', async () => {
+            StorageMock.setItem = jest.fn().mockRejectedValue(nonRetriableIdbError);
+
+            await Onyx.set(ONYXKEYS.TEST_KEY, {test: 'data'});
+
+            // Called once (initial attempt only) -- no recursion, unlike the 6 calls for generic errors
+            expect(retryOperationSpy).toHaveBeenCalledTimes(1);
+        });
+
+        it('should log a single skip alert for non-retriable errors', async () => {
+            const logAlertSpy = jest.spyOn(Logger, 'logAlert');
+            StorageMock.setItem = jest.fn().mockRejectedValue(nonRetriableIdbError);
+
+            await Onyx.set(ONYXKEYS.TEST_KEY, {test: 'data'});
+
+            expect(logAlertSpy).toHaveBeenCalledWith(`Storage operation skipped retry for non-retriable error. Error: ${nonRetriableIdbError}. onyxMethod: setWithRetry.`);
+            // Not paired with the "5 retries exhausted" alert
+            expect(logAlertSpy).toHaveBeenCalledTimes(1);
+        });
+
         it('should include the error in logAlert for IDBObjectStore invalid data errors', async () => {
             const logAlertSpy = jest.spyOn(Logger, 'logAlert');
             StorageMock.setItem = jest.fn().mockRejectedValueOnce(invalidDataError);