diff --git a/.readthedocs.yaml b/.readthedocs.yaml
new file mode 100644
index 0000000..efd5905
--- /dev/null
+++ b/.readthedocs.yaml
@@ -0,0 +1,41 @@
+# Read the Docs configuration file for Sphinx projects
+# See https://docs.readthedocs.io/en/stable/config-file/v2.html for details
+
+# Required
+version: 2
+
+
+# Set the OS, Python version and other tools you might need
+build:
+  os: ubuntu-latest
+  tools:
+    python: "3.11"
+
+    # You can also specify other tool versions:
+    # nodejs: "20"
+    # rust: "1.70"
+    # golang: "1.20"
+
+
+# Build documentation in the "docs/" directory with Sphinx
+sphinx:
+  configuration: docs/conf.py
+  # You can configure Sphinx to use a different builder, for instance use the dirhtml builder for simpler URLs
+  # builder: "dirhtml"
+  # Fail on all warnings to avoid broken references
+  # fail_on_warning: true
+
+# Optionally build your docs in additional formats such as PDF and ePub
+# formats:
+#   - pdf
+#   - epub
+
+
+# Optional but recommended, declare the Python requirements required
+# to build your documentation
+
+# See https://docs.readthedocs.io/en/stable/guides/reproducible-builds.html
+
+python:
+  install:
+    - requirements: docs/requirements.txt
diff --git a/README.md b/README.md
index 73c83f4..92c73a6 100644
--- a/README.md
+++ b/README.md
@@ -115,6 +115,16 @@ $ descriptive-analytics demo-projects/ARChetypeCRF_dengue_synthetic/
 The `descriptive-analytics` tool requires Google Chrome to be installed as some Chrome imaging functionality is used by the [`kaleido`](https://plotly.com/python/static-image-export/#kaleido) dependency when exporting/saving
 images - see [this](https://plotly.com/python/static-image-export/) for further information.
 
+## Documentation
+
+VERTEX project documentation is built with [Sphinx](https://www.sphinx-doc.org/en/) from content and configuration defined in the [`docs`](https://github.com/ISARICResearch/VERTEX/tree/main/docs) subfolder. Deployment will be to [ReadTheDocs](https://readthedocs.org) on a custom ISARIC domain, and is the process of being implemented.
+
+The documentation can be built locally by running:
+```shell
+make -C docs html
+```
+from the project root and then using a browser to open the `index.html` page in `docs/_build`. Changes to content can be made in the `docs/.rst` or `docs/sources/*.rst` files, and changes in configuration can be made in the `docs/conf.py` file. Any changes should be staged and version controlled in the normal way as with changes to code.
+
 ## Contributors
 
 - Esteban Garcia-Gallo - [esteban.garcia@ndm.ox.ac.uk](mailto:esteban.garcia@ndm.ox.ac.uk)
diff --git a/docs/requirements.txt b/docs/requirements.txt
new file mode 100644
index 0000000..d94c5de
--- /dev/null
+++ b/docs/requirements.txt
@@ -0,0 +1,1079 @@
+# This file is @generated by PDM.
+# Please do not edit it manually.
+
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+    --hash=sha256:d06bb1f751ba5d417047db62bca3c8fde202b8c11fb50742ab3ab962c81e8216 \
+    --hash=sha256:d304906ecc71672e9c89e87c4675dc5c2645e1f4269a5063b99b0bb29f232d13 \
+    --hash=sha256:e4e6b05a45525357e382909a4c1600444e2a45b4795163d3b22669285591c1ae \
+    --hash=sha256:e74a9a0f5e3fff48fb5a7f2fd2b9b70a3fe014a67522f79b7cca4c0c7e43c9ae \
+    --hash=sha256:ea37e7b45949df430fe649e5de8351c423430046a2af20b1c1961cae3afcda77 \
+    --hash=sha256:f64836de09927cba6f79dcd00fdd7d5329f3fccc633468507079c829ca4db4e3 \
+    --hash=sha256:fd6ec6be509c787f1caf6b247f0b1ca598bef13f4ddeaa126b7658215529ba0f \
+    --hash=sha256:fd907ae12cd483cd83e414b12941c632a969171bf90fc937d0c9f268a31cafff \
+    --hash=sha256:fd914713266421b7536de2bfa8181aa8c699432b6763a0ea64195ebe28bff6a9 \
+    --hash=sha256:fde6c716d51c04b1c25d0b90364d0be954624a0ee9d60e23e850e8d48353d07a
+cycler==0.12.1 \
+    --hash=sha256:85cef7cff222d8644161529808465972e51340599459b8ac3ccbac5a854e0d30 \
+    --hash=sha256:88bb128f02ba341da8ef447245a9e138fae777f6a23943da4540077d3601eb1c
+dash==3.4.0 \
+    --hash=sha256:3944beb32000ee8b22cd7fbb33545a0a43e25916c63aa41ba59ee5611997815e \
+    --hash=sha256:62b1c2eca3cfbe05f5e6ed8666e2c9a204aa08e2ceef89f01ce9bcccb3c18e95
+dash-bootstrap-components==2.0.4 \
+    --hash=sha256:767cf0084586c1b2b614ccf50f79fe4525fdbbf8e3a161ed60016e584a14f5d1 \
+    --hash=sha256:c3206c0923774bbc6a6ddaa7822b8d9aa5326b0d3c1e7cd795cc975025fe2484
+dnspython==2.8.0 \
+    --hash=sha256:01d9bbc4a2d76bf0db7c1f729812ded6d912bd318d3b1cf81d30c0f845dbf3af \
+    --hash=sha256:181d3c6996452cb1189c4046c61599b84a5a86e099562ffde77d26984ff26d0f
+email-validator==2.3.0 \
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+    --hash=sha256:9fc05c37f2f6cf439ff414f8fc46d917929974a82244c20eb10231ba60c54426
+flask==3.1.3 \
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+    --hash=sha256:f4bcbefc124291925f1a26446da31a5178f9483862233b23c0c96a20701f670c
+flask-login==0.6.3 \
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+    --hash=sha256:849b25b82a436bf830a054e74214074af59097171562ab10bfa999e6b78aae5d
+flask-principal==0.4.0 \
+    --hash=sha256:f5d6134b5caebfdbb86f32d56d18ee44b080876a27269560a96ea35f75c99453
+flask-security-too==5.6.2 \
+    --hash=sha256:5a48b9165146a02cb86a8073832df4ca177fbf4a7dbd707909279fbfad8a4032 \
+    --hash=sha256:61da7f4b6349e2cdf9f3ea53565cda2ed3588cd740a346be17f024f159e52c93
+flask-sqlalchemy==3.0.2 \
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+    --hash=sha256:7d0cd9cf73e64a996bb881a1ebd01633fc5a6d11c36ea27f7b5e251dc45476e7
+flask-wtf==1.2.2 \
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+    --hash=sha256:e93160c5c5b6b571cf99300b6e01b72f9a101027cab1579901f8b10c5daf0b70
+fonttools==4.62.1 \
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+    --hash=sha256:dc79476baa2d811b35798893eb2f2c1e51edee8d7a9c1429b400e56f4e0beccc
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+    --hash=sha256:c04c5e06ec3e022cbfe2cd4a846e1d4e50087444f875ff6d2c2ad8445495cf1a \
+    --hash=sha256:c2e47408e8ce1c6f1ceea0dffcdf6ebb85cc09e55c7af407c99f1112016e45e9 \
+    --hash=sha256:c56692189a7d1c7606cb794be0a8381470d95c57ce5be03fb3d0ef57c7853b86 \
+    --hash=sha256:ccd21bb86944ca9be6d967cf7691e658e43417782bce90b5d2faeda0ff78a7dd \
+    --hash=sha256:cd6f9e2bbd46321ba3bbb4c8a15794d32960e3b0ae2cc4d49a1a53d314805d71 \
+    --hash=sha256:d248d8c23c67d2291ffd47af766e2a3aa9fa1c6703155c099feb11f526c63a92 \
+    --hash=sha256:d3a62fa76a32b462a97198e4c9e99afb9ab375115e74e9a83ce180e7a496f643 \
+    --hash=sha256:e26e72bec7ab387ac80caa7496e0f908ff954f31065b0ffc1f8ecb1338b11b54 \
+    --hash=sha256:e3cb43ce200f59483eb82949bf1835a99cf43d7571e900d7c8d5c62cdf25d2f9
+gunicorn==25.3.0 \
+    --hash=sha256:cacea387dab08cd6776501621c295a904fe8e3b7aae9a1a3cbb26f4e7ed54660 \
+    --hash=sha256:f74e1b2f9f76f6cd1ca01198968bd2dd65830edc24b6e8e4d78de8320e2fe889
+idna==3.11 \
+    --hash=sha256:771a87f49d9defaf64091e6e6fe9c18d4833f140bd19464795bc32d966ca37ea \
+    --hash=sha256:795dafcc9c04ed0c1fb032c2aa73654d8e8c5023a7df64a53f39190ada629902
+importlib-metadata==9.0.0 \
+    --hash=sha256:2d21d1cc5a017bd0559e36150c21c830ab1dc304dedd1b7ea85d20f45ef3edd7 \
+    --hash=sha256:a4f57ab599e6a2e3016d7595cfd72eb4661a5106e787a95bcc90c7105b831efc
+importlib-resources==6.5.2 \
+    --hash=sha256:185f87adef5bcc288449d98fb4fba07cea78bc036455dd44c5fc4a2fe78fed2c \
+    --hash=sha256:789cfdc3ed28c78b67a06acb8126751ced69a3d5f79c095a98298cd8a760ccec
+interface-meta==1.3.0 \
+    --hash=sha256:8a4493f8bdb73fb9655dcd5115bc897e207319e36c8835f39c516a2d7e9d79a1 \
+    --hash=sha256:de35dc5241431886e709e20a14d6597ed07c9f1e8b4bfcffde2190ca5b700ee8
+itsdangerous==2.2.0 \
+    --hash=sha256:c6242fc49e35958c8b15141343aa660db5fc54d4f13a1db01a3f5891b98700ef \
+    --hash=sha256:e0050c0b7da1eea53ffaf149c0cfbb5c6e2e2b69c4bef22c81fa6eb73e5f6173
+jinja2==3.1.6 \
+    --hash=sha256:0137fb05990d35f1275a587e9aee6d56da821fc83491a0fb838183be43f66d6d \
+    --hash=sha256:85ece4451f492d0c13c5dd7c13a64681a86afae63a5f347908daf103ce6d2f67
+jmespath==1.1.0 \
+    --hash=sha256:472c87d80f36026ae83c6ddd0f1d05d4e510134ed462851fd5f754c8c3cbb88d \
+    --hash=sha256:a5663118de4908c91729bea0acadca56526eb2698e83de10cd116ae0f4e97c64
+joblib==1.5.3 \
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+    --hash=sha256:f821213d48f4ab353d20ebc24e4faf94ba40d76680642fb7ce2ea31a3ad94f9b
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+    --hash=sha256:defd50f72b65c5402ab2c573830a6978e5f202ad0d984793c8dde2c4152ebe04
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+    --hash=sha256:ff95d4264e55839be37bafe1536db2ab2de19da6b65f9244f01f332b5286cfbf
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+    --hash=sha256:df3e6b70f3192e92623128123ec8dca3067df9cfadd43d59681e210cfb8d4682
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