diff --git a/.github/workflows/e2e-integration.yml b/.github/workflows/e2e-integration.yml
index a61c8da..f3e3cd6 100644
--- a/.github/workflows/e2e-integration.yml
+++ b/.github/workflows/e2e-integration.yml
@@ -104,6 +104,12 @@ jobs:
           AWS_ACCOUNT_ID: ${{ secrets.AWS_ACCOUNT_ID }}
           AWS_REGION: ${{ secrets.AWS_REGION }}
 
+      - name: Run single building simulation test
+        run: make cli tests single-building
+        env:
+          AWS_ENV: local.host
+          HATCHET_ENV: local.host
+
       - name: Run E2E experiment
         id: e2e
         run: |
diff --git a/docker-compose.yml b/docker-compose.yml
index 497b8a1..c5a1d8a 100644
--- a/docker-compose.yml
+++ b/docker-compose.yml
@@ -19,6 +19,7 @@ services:
     volumes:
       - ./inputs:/code/inputs
       - ./outputs:/code/outputs
+      - ./tests/data/e2e:/code/tests/data/e2e
   fanouts:
     image: ${AWS_ACCOUNT_ID:-123456789012}.dkr.ecr.${AWS_REGION:-us-east-1}.amazonaws.com/hatchet/globi:${IMAGE_TAG:-latest}
     build:
diff --git a/src/globi/tools/cli/main.py b/src/globi/tools/cli/main.py
index f055c68..e36e447 100644
--- a/src/globi/tools/cli/main.py
+++ b/src/globi/tools/cli/main.py
@@ -203,6 +203,36 @@ def tests():
     pass
 
 
+@tests.command()
+@click.option(
+    "--config",
+    type=click.Path(exists=True),
+    default="tests/data/e2e/single-building.yml",
+    help="Path to the single building config YAML file.",
+)
+@click.option(
+    "--output-dir",
+    type=click.Path(file_okay=False),
+    default="outputs/single-building-test",
+    help="Output directory for simulation results.",
+)
+@click.pass_context
+def single_building(
+    ctx: click.Context,
+    config: str = "tests/data/e2e/single-building.yml",
+    output_dir: str = "outputs/single-building-test",
+):
+    """Run single building simulation test.
+
+    Intended for CI; run with: make cli-native tests single-building
+    """
+    import sys
+
+    ctx.invoke(simulate, config=Path(config), output_dir=Path(output_dir))
+    print("Single building simulation test passed.")
+    sys.exit(0)
+
+
 @tests.command()
 @click.option(
     "--manifest",
diff --git a/tests/data/e2e/single-building.yml b/tests/data/e2e/single-building.yml
new file mode 100644
index 0000000..2e0e819
--- /dev/null
+++ b/tests/data/e2e/single-building.yml
@@ -0,0 +1,20 @@
+# Single building simulation config for CLI/CI testing.
+# Uses test data from tests/data/e2e/ - run from repo root.
+db_file: tests/data/e2e/components-lib.db
+semantic_fields_file: tests/data/e2e/semantic-fields.yml
+component_map_file: tests/data/e2e/component-map.yml
+epwzip_file: "https://climate.onebuilding.org/WMO_Region_4_North_and_Central_America/USA_United_States_of_America/MA_Massachusetts/USA_MA_Boston-Logan.Intl.AP.725090_TMYx.2009-2023.zip"
+semantic_field_context:
+  Region: TestRegion
+  Typology: Residential
+  Age_bracket: Post_2000
+  Scenario: Baseline
+  Income: Low
+length: 20.0
+width: 15.0
+num_floors: 2
+f2f_height: 3.5
+wwr: 0.3
+basement: none
+attic: none
+exposed_basement_frac: 0.25