diff --git a/src/electron/frontend/core/components/Search.js b/src/electron/frontend/core/components/Search.js
index f348b4b26..51ade27e9 100644
--- a/src/electron/frontend/core/components/Search.js
+++ b/src/electron/frontend/core/components/Search.js
@@ -397,7 +397,11 @@ export class Search extends LitElement {
                         this.#onSelect(option);
                     });
 
-                    if (disabled) listItemElement.setAttribute("disabled", "");
+                    if (disabled) {
+                        listItemElement.setAttribute("disabled", "");
+                        if (option.disabledReason)
+                            listItemElement.style.setProperty("--disabled-label", `"${option.disabledReason}"`);
+                    }
 
                     const container = document.createElement("div");
 
diff --git a/src/electron/frontend/core/components/pages/guided-mode/data/GuidedStructure.js b/src/electron/frontend/core/components/pages/guided-mode/data/GuidedStructure.js
index 09cd85d48..c49f1f06f 100644
--- a/src/electron/frontend/core/components/pages/guided-mode/data/GuidedStructure.js
+++ b/src/electron/frontend/core/components/pages/guided-mode/data/GuidedStructure.js
@@ -3,7 +3,7 @@ import { Page } from "../../Page.js";
 
 // For Multi-Select Form
 import { Button } from "../../../Button.js";
-import { supportedInterfaces } from "../../../../globals";
+import { supportedInterfaces, windowsOnlyInterfaces } from "../../../../globals";
 import { Search } from "../../../Search.js";
 import { Modal } from "../../../Modal";
 import { List } from "../../../List";
@@ -129,13 +129,18 @@ export class GuidedStructurePage extends Page {
                 suffixes: value.suffixes ?? [],
             };
 
+            const isSupported = supportedInterfaces.includes(interfaceName);
+            const disabledReason =
+                !isSupported && windowsOnlyInterfaces.includes(interfaceName) ? "Windows only" : undefined;
+
             return {
                 ...value, // Contains label and name already (extra metadata)
                 key: displayName,
                 value: interfaceName,
                 structuredKeywords,
                 category,
-                disabled: !supportedInterfaces.includes(interfaceName),
+                disabled: !isSupported,
+                disabledReason,
             };
         });
 
diff --git a/src/electron/frontend/core/globals.js b/src/electron/frontend/core/globals.js
index 8bebbaaf2..587afe759 100644
--- a/src/electron/frontend/core/globals.js
+++ b/src/electron/frontend/core/globals.js
@@ -2,7 +2,12 @@ import { os, path, crypto, isElectron, isTestEnvironment } from "../utils/electr
 
 import paths from "../../../paths.config.json" assert { type: "json" };
 
-import supportedInterfaces from "../../../supported_interfaces.json" assert { type: "json" };
+import allSupportedInterfaces from "../../../supported_interfaces.json" assert { type: "json" };
+
+// Interfaces that are only supported on specific platforms
+const windowsOnlyInterfaces = ["Plexon2RecordingInterface"];
+const isWindows = os && os.platform() === "win32";
+const supportedInterfaces = allSupportedInterfaces.filter((name) => !windowsOnlyInterfaces.includes(name) || isWindows);
 
 export { isTestEnvironment };
 
@@ -44,4 +49,4 @@ export const ENCRYPTION_IV = isElectron ? crypto.randomBytes(IV_LENGTH) : "";
 // Storybook
 export const isStorybook = window.location.href.includes("iframe.html");
 
-export { supportedInterfaces };
+export { supportedInterfaces, windowsOnlyInterfaces };
diff --git a/src/supported_interfaces.json b/src/supported_interfaces.json
index 8b2fd5bac..1ad655159 100644
--- a/src/supported_interfaces.json
+++ b/src/supported_interfaces.json
@@ -43,5 +43,6 @@
     "BrukerTiffSinglePlaneConverter",
     "BrukerTiffMultiPlaneConverter",
     "MiniscopeConverter",
-    "CellExplorerRecordingInterface"
+    "CellExplorerRecordingInterface",
+    "Plexon2RecordingInterface"
 ]