diff --git a/src/evaluator.cpp b/src/evaluator.cpp
index 77d24695..99b0eb92 100644
--- a/src/evaluator.cpp
+++ b/src/evaluator.cpp
@@ -21,10 +21,23 @@ bool Evaluator::isTwoColorSystem() {
     if(!r)
         return false;
 
-    // NEXTSEQ500, NEXTSEQ 550/550DX, NOVASEQ
-    if(starts_with(r->mName, "@NS") || starts_with(r->mName, "@NB") || starts_with(r->mName, "@NDX") || starts_with(r->mName, "@A0")) {
-        delete r;
-        return true;
+    // Two-color system instrument prefixes
+    // See https://github.com/OpenGene/fastp/pull/508 for a detailed discussion
+    const vector<string> twoColorPrefixes = {
+        "@FS",  // iSeq 100
+        "@MN", "@SH",  // MiniSeq
+        "@NS", "@NB",  // NextSeq 500/550
+        "@NDX",  // NextSeq 550DX
+        "@VL", "@VH",  // NextSeq 1000/2000
+        "@A", "@NA",  // NovaSeq 6000
+        "@LH"  // NovaSeq X
+    };
+
+    for (const string& prefix : twoColorPrefixes) {
+        if (starts_with(r->mName, prefix)) {
+            delete r;
+            return true;
+        }
     }
 
     delete r;