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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="UTF-8" />
<meta name="viewport" content="width=device-width, initial-scale=1" />
<title>AI-driven modeling for preventing post-acute infection syndromes</title>
<!-- Bootstrap CSS -->
<link href="https://cdn.jsdelivr.net/npm/bootstrap@5.3.2/dist/css/bootstrap.min.css" rel="stylesheet" />
<style>
/* Make header/navigation sticky and add hover fade for menu items */
.navbar.sticky-top {
box-shadow: 0 2px 10px rgba(0,0,0,.1);
border-bottom: 3px solid #d3d3d3; /* lighter gray line */
margin: 0px;
padding: 0px;
}
.navbar .nav-link {
border-radius: 0; /* no rounded corners */
margin: 0 px;
height: 100%;
display: flex;
align-items: center;
transition: background-color .2s ease, color .2s ease;
}
.navbar .nav-link:hover {
background-color: rgba(255,255,255,.15); /* lighter on dark bg */
color: #fff;
}
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}
/* Smooth scrolling experience and anchor offset so content isn't hidden under sticky nav */
html { scroll-behavior: smooth; }
section { scroll-margin-top: 84px; }
/* Utility tweaks */
.hero {
background: linear-gradient(45deg, #0d6efd 0%, #9dfcff 100%);
color: #fff;
}
.hero p { opacity: .9; }
</style>
</head>
<body data-bs-spy="scroll" data-bs-target="#mainNav" data-bs-smooth-scroll="true" tabindex="0">
<!-- Navigation (sticky) -->
<nav id="mainNav" class="navbar navbar-expand-lg navbar-dark bg-dark sticky-top">
<div class="container">
<a class="navbar-brand fw-semibold" href="#start">AIMS</a>
<button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbarNav" aria-controls="navbarNav" aria-expanded="false" aria-label="Toggle navigation">
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<div class="collapse navbar-collapse" id="navbarNav">
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<li class="nav-item"><a class="nav-link active" href="index.html#start">Start</a></li>
<li class="nav-item"><a class="nav-link" href="index.html#goal">Summary</a></li>
<li class="nav-item"><a class="nav-link" href="index.html#work-packages">Work Packages</a></li>
<li class="nav-item"><a class="nav-link" href="index.html#team">Team</a></li>
<li class="nav-item"><a class="nav-link" href="index.html#publications">Publications</a></li>
<li class="nav-item"><a class="nav-link" href="index.html#presentations">Presentations</a></li>
<li class="nav-item"><a class="nav-link" href="index.html#software">Software</a></li>
<li class="nav-item"><a class="nav-link" href="index.html#contact">Contact</a></li>
</ul>
</div>
</div>
</nav>
<!-- Start / Hero Section -->
<header id="start" class="hero py-5">
<div class="container py-4">
<div class="row align-items-center g-4">
<div class="col-lg-7">
<h1 class="display-5 fw-bold">AI-driven modeling for preventing post-acute infection syndromes</h1>
<p class="lead mb-4">Leveraging artificial intelligence with mechanistic modeling and high-performance
computing</p>
<!-- <a href="#goal" class="btn btn-light btn-lg">Learn More</a> -->
</div>
<div class="col-lg-5 text-lg-end">
<!-- Optional illustration placeholder -->
<div class="ratio ratio-16x9 bg-white bg-opacity-25 rounded-3"
style="background: linear-gradient(rgba(255,255,255,0.5), rgba(255,255,255,0.5)),
url('bild_jonas.png') no-repeat center / cover;">
</div>
</div>
</div>
</header>
<!-- Background Section -->
<section id="goal" class="py-5">
<div class="container">
<h2 class="mb-4">Background</h2>
<ul>
<li>Dependent on the pathogen, up to 30 % of infected persons suffer from post-acute infection syndromes (PAIS) for many months or years after infection. The mechanisms of their development are not well understood.<sup>1</sup></li>
<li>Previous infections or vaccinations can reduce the risk of developing PAIS:<sup>2</sup></li>
<ul>
<li>Indirectly, by reducing the risk of infection and severe courses of the disease.</li>
<li>Directly, by a higher reaction of the immune system.</li>
</ul>
</ul>
<p style="font-size: 8pt;"><sup>1</sup> Choutka, J., Jansari, V., Hornig, M. & Iwasaki, A. <a href="https://doi.org/10.1038/s41591-022-01810-6">Unexplained post-acute infection syndromes</a>. Nature Medicine 28, 911–923 (2022).<br></bt><sup>2</sup> Mikolajczyk, R. et al. <a href="https://doi.org/10.1016/j.jinf.2024.106206">Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO)</a>. Journal of Infection 89 (2024)
</div>
<div class="container">
<h2 class="mb-4">Goals</h2>
<ul>
<li>Understand the key variables that are predictors of PAIS. Understand the impact of vaccinations on the risk of PAIS at the individual level.</li>
<li>Find optimal vaccination strategies to reduce the number of cases and the severity of PAIS.</li>
<li>Make efficient and scalable use of available resources.</li>
</ul>
</div>
</section>
<!-- Work Packages -->
<section id="work-packages" class="bg-light py-5">
<div class="container">
<h2 class="mb-4">Work Packages</h2>
<div class="row g-4">
<div class="col-md-6 col-lg-4">
<div class="card h-100">
<div class="card-body">
<h5 class="card-title">WP1 – Individual immunity and lifestyle / comorbidities- based reaction model</h5>
<p class="card-text">The goal of WP1 is the development of an individual immunity and lifestyle/comorbiditiesbased reaction model integrating key variables derived from analysis on the NAKO and
DigiHero data sets.</p>
</div>
</div>
</div>
<div class="col-md-6 col-lg-4">
<div class="card h-100">
<div class="card-body">
<h5 class="card-title">WP2 – AI-Simulation coupling: AI-based inference</h5>
<p class="card-text">The goal of WP2 is to provide the best-performing vaccination strategies to prevent the development of PAIS given the assumptions of the iteratively refined models. Furthermore, the second goal of WP2 is to provide freely accessible software and pipelines that can be reused by scientists and clinicians to infer estimations on parameters such as, e.g., antibody waning as soon as new data has been collected.</p>
</div>
</div>
</div>
<div class="col-md-6 col-lg-4">
<div class="card h-100">
<div class="card-body">
<h5 class="card-title">WP3 – Project coordination & Dissemination</h5>
<p class="card-text">Work package 3 is dedicated to project coordination and dissemination of results.</p>
</div>
</div>
</div>
</div>
</div>
</section>
<!-- Team Section -->
<section id="team" class="py-5">
<div class="container">
<h2 class="mb-4">Project Members</h2>
<div class="row">
<div class="col-md-4 text-center">
<img src="ubo.png" alt="University of Bonn" style="width: 150px; margin-top:0px; margin-bottom: 20px;"><br>
<img src="https://martinkuehn.eu/research/images/martin.png" class="rounded-circle mb-3" alt="Martin Kühn">
<h5>Dr. Martin Kühn</h5>
<p class="text-muted">Project Lead</p>
</div>
<div class="col-md-4 text-center">
<img src="ubo.png" alt="University of Bonn" style="width: 150px; margin-top:0px; margin-bottom: 20px;"><br>
<img src="https://martinkuehn.eu/research/images/carlotta.png" class="rounded-circle mb-3" alt="Carlotta Gerstein">
<h5>Carlotta Gerstein</h5>
<p class="text-muted">Project Member</p>
</div>
<div class="col-md-4 text-center">
<img src="hzi.png" alt="Helmholtz Centre for Infection Research" style="width: 130px; margin-top: 25px;"><br>
<img src="" class="rounded-circle mb-3" alt="">
<h5>Prof. Dr. Michael Meyer-Herrmann</h5>
<p class="text-muted">Project Member</p>
</div>
<div class="col-md-4 text-center">
<img src="hzi.png" alt="Helmholtz Centre for Infection Research" style="width: 130px; margin-top: 25px;"><br>
<img src="david_small.png" class="rounded-circle mb-3" alt="">
<h5>Dr. David Kerkmann</h5>
<p class="text-muted">Project Member</p>
</div>
<div class="col-md-4 text-center">
<img src="mlu.png" alt="Martin Luther University Halle-Wittenberg" style="width: 150px; margin-top: 20px;"><br>
<img src="rafael_small.png" class="rounded-circle mb-3" alt="">
<h5>Prof. Dr. Rafael Mikolajczyk</h5>
<p class="text-muted">Project Member</p>
</div>
<div class="col-md-4 text-center">
<img src="mlu.png" alt="Martin Luther University Halle-Wittenberg" style="width: 150px; margin-top: 20px;"><br>
<img src="jonas_small.png" class="rounded-circle mb-3" alt="">
<h5>Jonas Frost</h5>
<p class="text-muted">Project Member</p>
</div>
<div class="col-md-4 text-center">
</div>
</div>
</div>
</section>
<section id="team" class="py-5">
<div class="container">
<h2 class="mb-4">Direct external collaborators</h2>
<div class="row">
<div class="col-md-4 text-center">
<img src="ubo.png" alt="University of Bonn" style="width: 150px; margin-top:0px; margin-bottom: 20px;"><br>
<img src="roy_small.png" class="rounded-circle mb-3" alt="Roy Gusinow">
<h5>Roy Gusinow</h5>
</div>
</div>
</div>
</section>
<!-- Publications -->
<section id="publications" class="bg-light py-5">
<div class="container">
<h2 class="mb-4">Publications</h2>
<div class="table-responsive">
<table class="table align-middle">
<thead>
<tr>
<th scope="col">Year</th>
<th scope="col">Title</th>
<th scope="col">Authors</th>
<th scope="col">Journal</th>
<th scope="col">Links</th>
</tr>
</thead>
<tbody>
<!-- <tr>
<td>2025</td>
<td>AIMS - AI-driven Modeling for preventing post-acute infection Syndromes</td>
<td>Jonas Frost</td>
<td>Presentation (CAIMed Meetup)</td>
<td>
<a href="#" class="btn btn-sm btn-outline-primary">DOI</a>
<a href="#" class="btn btn-sm btn-outline-secondary">PDF</a>
</td>
</tr> -->
<!-- <tr>
<td>2025</td>
<td>AIMS - AI-driven Modeling for preventing post-acute infection Syndromes</td>
<td>Jonas Frost</td>
<td>Presentation (CAIMed Meetup)</td>
<td>
<a href="#" class="btn btn-sm btn-outline-primary">DOI</a>
<a href="#" class="btn btn-sm btn-outline-secondary">PDF</a>
</td>
</tr> -->
<!-- Add more rows as needed -->
</tbody>
</table>
</div>
</div>
</section>
<!-- Presentations -->
<section id="presentations" class="py-5">
<div class="container">
<h2 class="mb-4">Presentations</h2>
<div class="table-responsive">
<table class="table align-middle">
<thead>
<tr>
<th scope="col">Year</th>
<th scope="col">Title</th>
<th scope="col">Presenter</th>
<th scope="col">Venue</th>
<th scope="col">Links</th>
</tr>
</thead>
<tbody>
<tr>
<td>2025</td>
<td>AIMS - AI-driven Modeling for preventing post-acute infection Syndromes</td>
<td>Martin Kühn</td>
<td>CompLS Statusseminar</td>
<td>
<!-- <a href="#" class="btn btn-sm btn-outline-primary">DOI</a>
<a href="#" class="btn btn-sm btn-outline-secondary">PDF</a> -->
</td>
<tr>
<td>2025</td>
<td>AIMS - AI-driven Modeling for preventing post-acute infection Syndromes</td>
<td>Jonas Frost</td>
<td>CAIMed Meetup, Hannover</td>
<td>
<!-- <a href="#" class="btn btn-sm btn-outline-primary">DOI</a>
<a href="#" class="btn btn-sm btn-outline-secondary">PDF</a> -->
</td>
</tr>
</tr>
<!-- Add more rows as needed -->
</tbody>
</table>
</div>
</div>
</section>
<!-- Software -->
<section id="software" class="bg-light py-5">
<div class="container">
<h2 class="mb-4">Software</h2>
<ul class="list-group list-group-flush">
<li class="list-group-item d-flex justify-content-between align-items-center">
<span><strong>MEmilio</strong> – The software framework MEmilio is used for modeling and simulation of infectious disease dynamics and currently extended for PAIS.</span>
<a style="margin-left: auto" class="btn btn-sm btn-outline-dark" href="https://memilio.readthedocs.io/en/latest/">Documentation</a>
<a class="btn btn-sm btn-outline-dark" href="https://doi.org/10.5281/zenodo.16684608">Release v2.1.0</a>
</li>
<!-- <li class="list-group-item d-flex justify-content-between align-items-center">
<span><strong>dataset-name</strong> – curated dataset with documentation.</span>
<a class="btn btn-sm btn-outline-dark" href="#">Zenodo</a>
</li> -->
</ul>
</div>
</section>
<!-- Contact -->
<section id="contact" class="py-5">
<div class="container">
<h2 class="mb-4">Contact</h2>
<b>Dr. Martin Kühn</b><br>
E-Mail: Martin.Kuehn@uni-bonn.dee<br>
IRU Mathematics and Life Sciences, University of Bonn<br>
Endenicher Allee 64<br>
53115 Bonn<br>
Germany<p></p>
<img src="bmftr.jpg" alt="BMFTR" style="width: 250px; margin-top:0px; margin-bottom: 20px;">
</div>
</section>
<!-- Footer -->
<footer class="bg-dark text-white text-center py-3">
<div class="container">
<p class="mb-0"><a href="imprint.html">Imprint</a></p>
</div>
</footer>
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<script>
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document.getElementById('year').textContent = new Date().getFullYear();
</script>
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