Skip to content

Further optimize DP, VAF, and strand bias calculation  #8

@gtollefson

Description

@gtollefson

DP, VAF, and strand bias calculation takes a very long time because each indel range is used to query the bam file using readGAlignments() to retrieve information needed to calculate indel position coverage and distribution of +/- strands in reads at the indel position.

This could be made less expensive by querying the bam file only once using a Granges object of all indel ranges and then performing vectorized operations in parallel on the returned GAlignment object.

Metadata

Metadata

Assignees

Labels

enhancementNew feature or request

Type

No type

Projects

No projects

Relationships

None yet

Development

No branches or pull requests

Issue actions