diff --git a/src/js/_enqueues/vendor/plupload/handlers.js b/src/js/_enqueues/vendor/plupload/handlers.js
index 2e3125589558c..158ad427ccee2 100644
--- a/src/js/_enqueues/vendor/plupload/handlers.js
+++ b/src/js/_enqueues/vendor/plupload/handlers.js
@@ -285,7 +285,7 @@ function switchUploader( s ) {
 	}
 }
 
-function uploadError( fileObj, errorCode, message, up ) {
+function uploadError( fileObj, errorCode, message, up, errorObj ) {
 	var hundredmb = 100 * 1024 * 1024, max;
 
 	switch ( errorCode ) {
@@ -321,7 +321,11 @@ function uploadError( fileObj, errorCode, message, up ) {
 
 			break;
 		case plupload.HTTP_ERROR:
-			wpQueueError( pluploadL10n.http_error );
+			if ( errorObj && errorObj.status === 413 ) {
+				wpQueueError( pluploadL10n.http_error_413 );
+			} else {
+				wpQueueError( pluploadL10n.http_error );
+			}
 			break;
 		case plupload.INIT_ERROR:
 			jQuery( '.media-upload-form' ).addClass( 'html-uploader' );
@@ -643,7 +647,7 @@ jQuery( document ).ready( function( $ ) {
 				return;
 			}
 
-			uploadError( error.file, error.code, error.message, up );
+			uploadError( error.file, error.code, error.message, up, error );
 			up.refresh();
 		});
 
diff --git a/src/js/_enqueues/vendor/plupload/wp-plupload.js b/src/js/_enqueues/vendor/plupload/wp-plupload.js
index c0eb570657bf4..597149f22b186 100644
--- a/src/js/_enqueues/vendor/plupload/wp-plupload.js
+++ b/src/js/_enqueues/vendor/plupload/wp-plupload.js
@@ -484,7 +484,11 @@ window.wp = window.wp || {};
 			return pluploadL10n.file_exceeds_size_limit.replace( '%s', file.name );
 		},
 
-		'HTTP_ERROR': function( file ) {
+		'HTTP_ERROR': function( file, data ) {
+			if ( data && data.status === 413 ) {
+				return pluploadL10n.http_error_413;
+			}
+
 			if ( file.type && file.type.indexOf( 'image/' ) === 0 ) {
 				return pluploadL10n.http_error_image;
 			}
diff --git a/src/wp-includes/script-loader.php b/src/wp-includes/script-loader.php
index 42d42b3f8781d..a9e821ad1eab4 100644
--- a/src/wp-includes/script-loader.php
+++ b/src/wp-includes/script-loader.php
@@ -1020,6 +1020,7 @@ function wp_default_scripts( $scripts ) {
 		'missing_upload_url'        => __( 'There was a configuration error. Please contact the server administrator.' ),
 		'upload_limit_exceeded'     => __( 'You may only upload 1 file.' ),
 		'http_error'                => __( 'Unexpected response from the server. The file may have been uploaded successfully. Check in the Media Library or reload the page.' ),
+		'http_error_413'            => __( 'HTTP error 413. The server has rejected the upload because the request was too large. This is a server configuration limit and is separate from the maximum file size shown on this page. Please contact the site administrator.' ),
 		'http_error_image'          => __( 'The server cannot process the image. This can happen if the server is busy or does not have enough resources to complete the task. Uploading a smaller image may help. Suggested maximum size is 2560 pixels.' ),
 		'upload_failed'             => __( 'Upload failed.' ),
 		/* translators: 1: Opening link tag, 2: Closing link tag. */