diff --git a/packages/angular/ssr/src/utils/ng.ts b/packages/angular/ssr/src/utils/ng.ts
index 16e059e6aaf2..acf2df180f32 100644
--- a/packages/angular/ssr/src/utils/ng.ts
+++ b/packages/angular/ssr/src/utils/ng.ts
@@ -59,7 +59,10 @@ export async function renderAngular(
   url: URL,
   platformProviders: StaticProvider[],
   serverContext: string,
-): Promise<{ hasNavigationError: boolean; redirectTo?: string; content: () => Promise<string> }> {
+): Promise<
+  | { hasNavigationError: true }
+  | { hasNavigationError: boolean; redirectTo?: string; content: () => Promise<string> }
+> {
   // A request to `http://www.example.com/page/index.html` will render the Angular route corresponding to `http://www.example.com/page`.
   const urlToRender = stripIndexHtmlFromURL(url);
   const platformRef = platformServer([
@@ -100,6 +103,13 @@ export async function renderAngular(
     // Block until application is stable.
     await applicationRef.whenStable();
 
+    // This code protect against app destruction during bootstrapping which is a
+    // valid case. We should not assume the `applicationRef` is not in destroyed state.
+    // Calling `envInjector.get` would throw `NG0205: Injector has already been destroyed`.
+    if (applicationRef.destroyed) {
+      return { hasNavigationError: true };
+    }
+
     // TODO(alanagius): Find a way to avoid rendering here especially for redirects as any output will be discarded.
     const envInjector = applicationRef.injector;
     const routerIsProvided = !!envInjector.get(ActivatedRoute, null);
diff --git a/packages/angular/ssr/test/app_spec.ts b/packages/angular/ssr/test/app_spec.ts
index 9584feafeb72..a72c4d75fae2 100644
--- a/packages/angular/ssr/test/app_spec.ts
+++ b/packages/angular/ssr/test/app_spec.ts
@@ -12,8 +12,8 @@ import '@angular/compiler';
 /* eslint-enable import/no-unassigned-import */
 
 import { APP_BASE_HREF } from '@angular/common';
-import { Component, REQUEST, RESPONSE_INIT, inject } from '@angular/core';
-import { CanActivateFn, Router } from '@angular/router';
+import { Component, PlatformRef, REQUEST, RESPONSE_INIT, inject } from '@angular/core';
+import { ActivatedRoute, CanActivateFn, Router } from '@angular/router';
 import { AngularServerApp } from '../src/app';
 import { RenderMode } from '../src/routes/route-config';
 import { setAngularAppTestingManifest } from './testing-utils';
@@ -26,7 +26,13 @@ describe('AngularServerApp', () => {
       selector: 'app-home',
       template: `Home works`,
     })
-    class HomeComponent {}
+    class HomeComponent {
+      constructor() {
+        if (inject(ActivatedRoute).snapshot.data['destroyApp']) {
+          inject(PlatformRef).destroy();
+        }
+      }
+    }
 
     @Component({
       selector: 'app-redirect',
@@ -65,7 +71,7 @@ describe('AngularServerApp', () => {
         { path: 'home-ssg', component: HomeComponent },
         { path: 'page-with-headers', component: HomeComponent },
         { path: 'page-with-status', component: HomeComponent },
-
+        { path: 'page-destroy-app', component: HomeComponent, data: { destroyApp: true } },
         { path: 'redirect', redirectTo: 'home' },
         { path: 'redirect-via-navigate', component: RedirectComponent },
         {
@@ -227,6 +233,13 @@ describe('AngularServerApp', () => {
         expect(response?.status).toBe(201);
       });
 
+      it('should not throw an error when app destroys itself', async () => {
+        const response = await app.handle(new Request('http://localhost/page-destroy-app'));
+        // The test expects response to be null, which is reasonable - if the app destroys
+        // itself, there's nothing to render.
+        expect(response).toBeNull();
+      });
+
       it('should return static `index.csr.html` for routes with CSR rendering mode', async () => {
         const response = await app.handle(new Request('http://localhost/home-csr'));
         const content = await response?.text();