diff --git a/CHANGES.md b/CHANGES.md
index cc1ec48ba188..5ea1c49c09e2 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -78,6 +78,7 @@
 
 ## Breaking Changes
 
+* (Python) Made Beartype the default fallback type checking tool. This can be disabled with the `--disable_beartype` pipeline option. ([#38275](https://github.com/apache/beam/issues/38275))
 * X behavior was changed ([#X](https://github.com/apache/beam/issues/X)).
 
 ## Deprecations
diff --git a/sdks/python/apache_beam/options/pipeline_options.py b/sdks/python/apache_beam/options/pipeline_options.py
index d60d75283eab..163729d24dd7 100644
--- a/sdks/python/apache_beam/options/pipeline_options.py
+++ b/sdks/python/apache_beam/options/pipeline_options.py
@@ -886,6 +886,11 @@ def _add_argparse_args(cls, parser):
         action='store_false',
         help='Disable type checking at pipeline construction '
         'time')
+    parser.add_argument(
+        '--disable_beartype',
+        default=False,
+        action='store_true',
+        help='Disable the use of beartype for type checking.')
     parser.add_argument(
         '--runtime_type_check',
         default=False,
diff --git a/sdks/python/apache_beam/typehints/typehints.py b/sdks/python/apache_beam/typehints/typehints.py
index f429935c3a0e..bfd74ef7cd1a 100644
--- a/sdks/python/apache_beam/typehints/typehints.py
+++ b/sdks/python/apache_beam/typehints/typehints.py
@@ -1485,7 +1485,8 @@ def normalize(x, none_as_type=False):
 })
 
 
-def is_consistent_with(sub, base, use_beartype: bool = False) -> bool:
+def is_consistent_with(
+    sub, base, use_beartype: typing.Optional[bool] = None) -> bool:
   """Checks whether sub a is consistent with base.
 
   This is according to the terminology of PEP 483/484.  This relationship is
@@ -1494,6 +1495,15 @@ def is_consistent_with(sub, base, use_beartype: bool = False) -> bool:
   relation, but also handles the special Any type as well as type
   parameterization.
   """
+  if use_beartype is None:
+    from apache_beam.options.pipeline_options_context import get_pipeline_options
+    options = get_pipeline_options()
+    if options:
+      from apache_beam.options.pipeline_options import TypeOptions
+      use_beartype = not options.view_as(TypeOptions).disable_beartype
+    else:
+      use_beartype = True
+
   from apache_beam.pvalue import Row
   from apache_beam.typehints.row_type import RowTypeConstraint
   if sub == base:
diff --git a/sdks/python/apache_beam/typehints/typehints_test.py b/sdks/python/apache_beam/typehints/typehints_test.py
index 992c129fd8a5..3806f65ac429 100644
--- a/sdks/python/apache_beam/typehints/typehints_test.py
+++ b/sdks/python/apache_beam/typehints/typehints_test.py
@@ -1613,6 +1613,33 @@ def test_hint_helper_pipe_union(self):
     self.assertTrue(is_consistent_with(int, pipe_union_2))
     self.assertTrue(is_consistent_with(float, pipe_union_2))
 
+  def test_is_consistent_with_disable_beartype(self):
+    import unittest.mock
+
+    from apache_beam.options.pipeline_options import PipelineOptions
+    from apache_beam.options.pipeline_options_context import scoped_pipeline_options
+
+    with unittest.mock.patch(
+        'apache_beam.typehints.typehints.is_subhint') as mock_is_subhint:
+      mock_is_subhint.return_value = True
+
+      class A:
+        pass
+
+      class B(A):
+        pass
+
+      options = PipelineOptions([])
+      with scoped_pipeline_options(options):
+        typehints.is_consistent_with(B, A)
+        self.assertTrue(mock_is_subhint.called)
+        mock_is_subhint.reset_mock()
+
+      options = PipelineOptions(['--disable_beartype'])
+      with scoped_pipeline_options(options):
+        typehints.is_consistent_with(B, A)
+        self.assertFalse(mock_is_subhint.called)
+
   def test_positional_arg_hints(self):
     self.assertEqual(typehints.Any, _positional_arg_hints('x', {}))
     self.assertEqual(int, _positional_arg_hints('x', {'x': int}))