diff --git a/hw/cmsis-core/include/arm_mpu.h b/hw/cmsis-core/include/arm_mpu.h
new file mode 100644
index 0000000000..e8d5061989
--- /dev/null
+++ b/hw/cmsis-core/include/arm_mpu.h
@@ -0,0 +1,45 @@
+/*
+ * Licensed to the Apache Software Foundation (ASF) under one
+ * or more contributor license agreements.  See the NOTICE file
+ * distributed with this work for additional information
+ * regarding copyright ownership.  The ASF licenses this file
+ * to you under the Apache License, Version 2.0 (the
+ * "License"); you may not use this file except in compliance
+ * with the License.  You may obtain a copy of the License at
+ *
+ *  http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing,
+ * software distributed under the License is distributed on an
+ * "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+ * KIND, either express or implied.  See the License for the
+ * specific language governing permissions and limitations
+ * under the License.
+ */
+
+#ifndef ARM_MPU_H
+#define ARM_MPU_H
+
+#include <os/mynewt.h>
+#include <os/link_tables.h>
+
+#if __MPU_PRESENT
+#if (__CORTEX_M == 0) || (__CORTEX_M == 3) || (__CORTEX_M == 4) || (__CORTEX_M == 7)
+
+LINK_TABLE(ARM_MPU_Region_t, mpu_regions);
+
+#define MPU_ARM_V7_REGION(name, address, rasr)                                \
+    LINK_TABLE_ELEMENT(mpu_regions, name) = {                                 \
+        .RBAR = address | MPU_RBAR_VALID_Msk,                                 \
+        .RASR = rasr,                                                         \
+    };
+
+#elif (__CORTEX_M == 23) || (__CORTEX_M == 33) || (__CORTEX_M == 34) ||       \
+    (__CORTEX_M == 35)
+/* TODO: Add support for MPU ARMV8 */
+#endif
+
+void arm_mpu_init(void);
+
+#endif
+#endif
diff --git a/hw/cmsis-core/pkg.yml b/hw/cmsis-core/pkg.yml
index c5e004bb54..0fcf4dbf41 100644
--- a/hw/cmsis-core/pkg.yml
+++ b/hw/cmsis-core/pkg.yml
@@ -31,6 +31,9 @@ pkg.include_dirs:
     - "@arm-CMSIS_5/CMSIS/Core/Include"
     - "@arm-CMSIS_5/CMSIS/DSP/Include"
 
+pkg.link_tables:
+    - mpu_regions
+
 repository.arm-CMSIS_5:
     type: github
     vers: 5.9.0-commit
diff --git a/hw/cmsis-core/src/arm_mpu.c b/hw/cmsis-core/src/arm_mpu.c
new file mode 100644
index 0000000000..8a064f22ca
--- /dev/null
+++ b/hw/cmsis-core/src/arm_mpu.c
@@ -0,0 +1,53 @@
+/*
+ * Licensed to the Apache Software Foundation (ASF) under one
+ * or more contributor license agreements.  See the NOTICE file
+ * distributed with this work for additional information
+ * regarding copyright ownership.  The ASF licenses this file
+ * to you under the Apache License, Version 2.0 (the
+ * "License"); you may not use this file except in compliance
+ * with the License.  You may obtain a copy of the License at
+ *
+ *  http://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing,
+ * software distributed under the License is distributed on an
+ * "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+ * KIND, either express or implied.  See the License for the
+ * specific language governing permissions and limitations
+ * under the License.
+ */
+
+#include <os/os.h>
+#include <os/link_tables.h>
+#include <arm_mpu.h>
+
+#ifndef __CORTEX_M
+#error "Macro __CORTEX_M not defined; must define cortex-m type!"
+#endif
+
+#if __MPU_PRESENT
+#if (__CORTEX_M == 0) || (__CORTEX_M == 3) || (__CORTEX_M == 4) || (__CORTEX_M == 7)
+
+void
+arm_mpu_init(void)
+{
+    ARM_MPU_Region_t regions[8] = { 0 };
+    size_t size = min(ARRAY_SIZE(regions), mpu_regions_size());
+
+    ARM_MPU_Disable();
+
+    for (size_t i = 0; i < size; ++i) {
+        regions[i].RBAR = (mpu_regions[i].RBAR & ~MPU_RBAR_REGION_Msk) | i;
+        regions[i].RASR = mpu_regions[i].RASR;
+    }
+
+    ARM_MPU_Load(regions, size);
+
+    ARM_MPU_Enable(MPU_CTRL_PRIVDEFENA_Msk);
+}
+#elif (__CORTEX_M == 23) || (__CORTEX_M == 33) || (__CORTEX_M == 34) ||       \
+    (__CORTEX_M == 35)
+/* TODO: Add support for MPU ARMV8 */
+#endif
+
+#endif
diff --git a/hw/cmsis-core/syscfg.yml b/hw/cmsis-core/syscfg.yml
new file mode 100644
index 0000000000..57fde89876
--- /dev/null
+++ b/hw/cmsis-core/syscfg.yml
@@ -0,0 +1,23 @@
+# Licensed to the Apache Software Foundation (ASF) under one
+# or more contributor license agreements.  See the NOTICE file
+# distributed with this work for additional information
+# regarding copyright ownership.  The ASF licenses this file
+# to you under the Apache License, Version 2.0 (the
+# "License"); you may not use this file except in compliance
+# with the License.  You may obtain a copy of the License at
+#
+#  http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing,
+# software distributed under the License is distributed on an
+# "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY
+# KIND, either express or implied.  See the License for the
+# specific language governing permissions and limitations
+# under the License.
+#
+
+syscfg.defs:
+    ARM_MPU:
+        description: ARM MPU is present
+        value:
+