diff --git a/cpython-unix/build-cpython.sh b/cpython-unix/build-cpython.sh
index 6df845881..d112f069a 100755
--- a/cpython-unix/build-cpython.sh
+++ b/cpython-unix/build-cpython.sh
@@ -85,6 +85,19 @@ if [ -n "${CROSS_COMPILING}" ]; then
     fi
 fi
 
+# Inject -Bsymbolic* on shared library to force direct symbol resolution
+# and potentially unlock more compiler+linker optimizations.
+#
+# Patch is safe on all arches but runs into context conflict on macOS.
+# It isn't needed for macOS. So workaround by not applying there.
+if [[ "${PYBUILD_PLATFORM}" != macos* ]]; then
+    if [ -n "${PYTHON_MEETS_MINIMUM_VERSION_3_11}" ]; then
+      patch -p1 -i "${ROOT}/patch-configure-linker-symbolic.patch"
+    else
+      patch -p1 -i "${ROOT}/patch-configure-linker-symbolic-3.10.patch"
+    fi
+fi
+
 # LIBTOOL_CRUFT is unused and breaks cross-compiling on macOS. Nuke it.
 # Submitted upstream at https://github.com/python/cpython/pull/101048.
 if [ -n "${PYTHON_MEETS_MAXIMUM_VERSION_3_11}" ]; then
diff --git a/cpython-unix/patch-configure-linker-symbolic-3.10.patch b/cpython-unix/patch-configure-linker-symbolic-3.10.patch
new file mode 100644
index 000000000..045d1c4e3
--- /dev/null
+++ b/cpython-unix/patch-configure-linker-symbolic-3.10.patch
@@ -0,0 +1,23 @@
+diff --git a/configure.ac b/configure.ac
+index ac3be3850a9..88a2027f517 100644
+--- a/configure.ac
++++ b/configure.ac
+@@ -2713,8 +2713,16 @@ then
+ 		fi
+ 		;;
+ 	Linux*|GNU*|QNX*|VxWorks*)
+-		LDSHARED='$(CC) -shared'
+-		LDCXXSHARED='$(CXX) -shared';;
++		# See https://maskray.me/blog/2021-05-16-elf-interposition-and-bsymbolic.
++		# This is related to the -fno-semantic-interposition optimization that
++		# --enable-optimizations engages automatically. It changes the linkage
++		# behavior so the runtime loader searches the current DSO first before
++		# falling back to the default search mechanism of the executable plus
++		# all its loaded DSOs. It has much the same effect as
++		# -fno-semantic-interposition but can also enable optimizations across
++		# translation units.
++		LDSHARED='$(CC) -shared -Wl,-Bsymbolic-functions'
++		LDCXXSHARED='$(CXX) -shared -Wl,-Bsymbolic-functions';;
+ 	FreeBSD*)
+ 		if [[ "`$CC -dM -E - </dev/null | grep __ELF__`" != "" ]]
+ 		then
diff --git a/cpython-unix/patch-configure-linker-symbolic.patch b/cpython-unix/patch-configure-linker-symbolic.patch
new file mode 100644
index 000000000..7c063ed45
--- /dev/null
+++ b/cpython-unix/patch-configure-linker-symbolic.patch
@@ -0,0 +1,23 @@
+diff --git a/configure.ac b/configure.ac
+index a1f4a567095..f7aa69556e5 100644
+--- a/configure.ac
++++ b/configure.ac
+@@ -3489,8 +3489,16 @@ then
+ 		LDSHARED='$(CC) -shared'
+ 		LDCXXSHARED='$(CXX) -shared';;
+ 	Linux*|GNU*|QNX*|VxWorks*|Haiku*)
+-		LDSHARED='$(CC) -shared'
+-		LDCXXSHARED='$(CXX) -shared';;
++		# See https://maskray.me/blog/2021-05-16-elf-interposition-and-bsymbolic.
++		# This is related to the -fno-semantic-interposition optimization that
++		# --enable-optimizations engages automatically. It changes the linkage
++		# behavior so the runtime loader searches the current DSO first before
++		# falling back to the default search mechanism of the executable plus
++		# all its loaded DSOs. It has much the same effect as
++		# -fno-semantic-interposition but can also enable optimizations across
++		# translation units.
++		LDSHARED='$(CC) -shared -Wl,-Bsymbolic-functions'
++		LDCXXSHARED='$(CXX) -shared -Wl,-Bsymbolic-functions';;
+ 	FreeBSD*)
+ 		if [[ "`$CC -dM -E - </dev/null | grep __ELF__`" != "" ]]
+ 		then
diff --git a/docs/quirks.rst b/docs/quirks.rst
index 1259f23ef..60b1fd2f9 100644
--- a/docs/quirks.rst
+++ b/docs/quirks.rst
@@ -194,6 +194,22 @@ compile extensions, too.
 If there is a build time normalization that you think should be performed to
 make distributions more portable, please file a GitHub issue.
 
+.. _quirk_ld_preload_doesnt_work:
+
+``LD_PRELOAD`` Does Not Work
+============================
+
+This project applies various build optimizations that undermine the
+ability for ``LD_PRELOAD`` to reliably intercept symbols provided by
+``libpython``:
+
+* Functions can be aggressively inlined - bypassing the PLT - and inlined
+  function calls cannot be intercepted by ``LD_PRELOAD``'d libraries.
+* Use of the linker option ``-Bsymbolic-functions`` on ``libpython`` forces
+  symbols to resolve to the local library (``libpython``) instead of going
+  through the regular loader lookup sequence, which would otherwise process
+  ``LD_PRELOAD``'d libraries before ``libpython``.
+
 .. _quirk_former:
 .. _quirk_missing_libcrypt:
 .. _quirk_linux_libx11: