diff --git a/.changeset/inference-profile-models.md b/.changeset/inference-profile-models.md
new file mode 100644
index 00000000..94bff304
--- /dev/null
+++ b/.changeset/inference-profile-models.md
@@ -0,0 +1,5 @@
+---
+'@aws-amplify/data-schema': minor
+---
+
+Add new Bedrock models and cross-region inference profile variants to the AI model registry. New foundation models include Claude Opus 4.1/4.6, Sonnet 4.6, DeepSeek R1, Llama 3.2/3.3/4, Amazon Nova Premier, and Pixtral Large. Inference profile variants use (US), (EU), (APAC), (AU), (JP), (CA), (Global) naming convention for models that support cross-region inference.
diff --git a/packages/data-schema/src/ai/ModelType.ts b/packages/data-schema/src/ai/ModelType.ts
index 58bf3c2d..b548a3da 100644
--- a/packages/data-schema/src/ai/ModelType.ts
+++ b/packages/data-schema/src/ai/ModelType.ts
@@ -4,11 +4,29 @@
 import { AiModel } from '@aws-amplify/data-schema-types';
 
 const supportedModelsLookup = {
+  // ============================================================
   // Amazon Nova models
+  // ============================================================
   'Amazon Nova Pro': 'amazon.nova-pro-v1:0',
   'Amazon Nova Lite': 'amazon.nova-lite-v1:0',
   'Amazon Nova Micro': 'amazon.nova-micro-v1:0',
-  // Anthropic models
+  'Amazon Nova Premier': 'amazon.nova-premier-v1:0',
+  // Amazon Nova inference profiles
+  'Amazon Nova Pro (US)': 'us.amazon.nova-pro-v1:0',
+  'Amazon Nova Pro (EU)': 'eu.amazon.nova-pro-v1:0',
+  'Amazon Nova Pro (APAC)': 'apac.amazon.nova-pro-v1:0',
+  'Amazon Nova Lite (US)': 'us.amazon.nova-lite-v1:0',
+  'Amazon Nova Lite (EU)': 'eu.amazon.nova-lite-v1:0',
+  'Amazon Nova Lite (APAC)': 'apac.amazon.nova-lite-v1:0',
+  'Amazon Nova Lite (CA)': 'ca.amazon.nova-lite-v1:0',
+  'Amazon Nova Micro (US)': 'us.amazon.nova-micro-v1:0',
+  'Amazon Nova Micro (EU)': 'eu.amazon.nova-micro-v1:0',
+  'Amazon Nova Micro (APAC)': 'apac.amazon.nova-micro-v1:0',
+  'Amazon Nova Premier (US)': 'us.amazon.nova-premier-v1:0',
+
+  // ============================================================
+  // Anthropic Claude models
+  // ============================================================
   'Claude 3 Haiku': 'anthropic.claude-3-haiku-20240307-v1:0',
   'Claude 3 Opus': 'anthropic.claude-3-opus-20240229-v1:0',
   'Claude 3 Sonnet': 'anthropic.claude-3-sonnet-20240229-v1:0',
@@ -17,22 +35,111 @@ const supportedModelsLookup = {
   'Claude 3.5 Sonnet v2': 'anthropic.claude-3-5-sonnet-20241022-v2:0',
   'Claude 3.7 Sonnet': 'anthropic.claude-3-7-sonnet-20250219-v1:0',
   'Claude Opus 4': 'anthropic.claude-opus-4-20250514-v1:0',
+  'Claude Opus 4.1': 'anthropic.claude-opus-4-1-20250805-v1:0',
   'Claude Sonnet 4': 'anthropic.claude-sonnet-4-20250514-v1:0',
-  // Claude 4.5 models (require global inference profiles)
+  'Claude Sonnet 4.6': 'anthropic.claude-sonnet-4-6',
+  'Claude Opus 4.6': 'anthropic.claude-opus-4-6-v1',
+  // Claude 4.5 models (require global inference profiles — DO NOT CHANGE existing mappings)
   'Claude Haiku 4.5': 'global.anthropic.claude-haiku-4-5-20251001-v1:0',
   'Claude Sonnet 4.5': 'global.anthropic.claude-sonnet-4-5-20250929-v1:0',
   'Claude Opus 4.5': 'global.anthropic.claude-opus-4-5-20251101-v1:0',
+  // Anthropic inference profiles
+  'Claude 3 Haiku (US)': 'us.anthropic.claude-3-haiku-20240307-v1:0',
+  'Claude 3 Haiku (EU)': 'eu.anthropic.claude-3-haiku-20240307-v1:0',
+  'Claude 3 Haiku (APAC)': 'apac.anthropic.claude-3-haiku-20240307-v1:0',
+  'Claude 3 Opus (US)': 'us.anthropic.claude-3-opus-20240229-v1:0',
+  'Claude 3 Sonnet (US)': 'us.anthropic.claude-3-sonnet-20240229-v1:0',
+  'Claude 3 Sonnet (EU)': 'eu.anthropic.claude-3-sonnet-20240229-v1:0',
+  'Claude 3 Sonnet (APAC)': 'apac.anthropic.claude-3-sonnet-20240229-v1:0',
+  'Claude 3.5 Haiku (US)': 'us.anthropic.claude-3-5-haiku-20241022-v1:0',
+  'Claude 3.5 Sonnet (US)': 'us.anthropic.claude-3-5-sonnet-20240620-v1:0',
+  'Claude 3.5 Sonnet (EU)': 'eu.anthropic.claude-3-5-sonnet-20240620-v1:0',
+  'Claude 3.5 Sonnet (APAC)': 'apac.anthropic.claude-3-5-sonnet-20240620-v1:0',
+  'Claude 3.5 Sonnet v2 (US)': 'us.anthropic.claude-3-5-sonnet-20241022-v2:0',
+  'Claude 3.5 Sonnet v2 (APAC)':
+    'apac.anthropic.claude-3-5-sonnet-20241022-v2:0',
+  'Claude 3.7 Sonnet (US)': 'us.anthropic.claude-3-7-sonnet-20250219-v1:0',
+  'Claude 3.7 Sonnet (EU)': 'eu.anthropic.claude-3-7-sonnet-20250219-v1:0',
+  'Claude 3.7 Sonnet (APAC)': 'apac.anthropic.claude-3-7-sonnet-20250219-v1:0',
+  'Claude Opus 4 (US)': 'us.anthropic.claude-opus-4-20250514-v1:0',
+  'Claude Opus 4.1 (US)': 'us.anthropic.claude-opus-4-1-20250805-v1:0',
+  'Claude Sonnet 4 (US)': 'us.anthropic.claude-sonnet-4-20250514-v1:0',
+  'Claude Sonnet 4 (EU)': 'eu.anthropic.claude-sonnet-4-20250514-v1:0',
+  'Claude Sonnet 4 (APAC)': 'apac.anthropic.claude-sonnet-4-20250514-v1:0',
+  'Claude Sonnet 4 (Global)': 'global.anthropic.claude-sonnet-4-20250514-v1:0',
+  'Claude Haiku 4.5 (US)': 'us.anthropic.claude-haiku-4-5-20251001-v1:0',
+  'Claude Haiku 4.5 (EU)': 'eu.anthropic.claude-haiku-4-5-20251001-v1:0',
+  'Claude Haiku 4.5 (AU)': 'au.anthropic.claude-haiku-4-5-20251001-v1:0',
+  'Claude Haiku 4.5 (JP)': 'jp.anthropic.claude-haiku-4-5-20251001-v1:0',
+  'Claude Haiku 4.5 (Global)':
+    'global.anthropic.claude-haiku-4-5-20251001-v1:0',
+  'Claude Sonnet 4.5 (US)': 'us.anthropic.claude-sonnet-4-5-20250929-v1:0',
+  'Claude Sonnet 4.5 (EU)': 'eu.anthropic.claude-sonnet-4-5-20250929-v1:0',
+  'Claude Sonnet 4.5 (AU)': 'au.anthropic.claude-sonnet-4-5-20250929-v1:0',
+  'Claude Sonnet 4.5 (JP)': 'jp.anthropic.claude-sonnet-4-5-20250929-v1:0',
+  'Claude Sonnet 4.5 (Global)':
+    'global.anthropic.claude-sonnet-4-5-20250929-v1:0',
+  'Claude Opus 4.5 (US)': 'us.anthropic.claude-opus-4-5-20251101-v1:0',
+  'Claude Opus 4.5 (EU)': 'eu.anthropic.claude-opus-4-5-20251101-v1:0',
+  'Claude Opus 4.5 (Global)': 'global.anthropic.claude-opus-4-5-20251101-v1:0',
+  'Claude Sonnet 4.6 (US)': 'us.anthropic.claude-sonnet-4-6',
+  'Claude Sonnet 4.6 (EU)': 'eu.anthropic.claude-sonnet-4-6',
+  'Claude Sonnet 4.6 (AU)': 'au.anthropic.claude-sonnet-4-6',
+  'Claude Sonnet 4.6 (JP)': 'jp.anthropic.claude-sonnet-4-6',
+  'Claude Sonnet 4.6 (Global)': 'global.anthropic.claude-sonnet-4-6',
+  'Claude Opus 4.6 (US)': 'us.anthropic.claude-opus-4-6-v1',
+  'Claude Opus 4.6 (EU)': 'eu.anthropic.claude-opus-4-6-v1',
+  'Claude Opus 4.6 (AU)': 'au.anthropic.claude-opus-4-6-v1',
+
+  // ============================================================
   // Cohere models
+  // ============================================================
   'Cohere Command R': 'cohere.command-r-v1:0',
   'Cohere Command R+': 'cohere.command-r-plus-v1:0',
-  // Meta models
+
+  // ============================================================
+  // DeepSeek models
+  // ============================================================
+  'DeepSeek R1': 'deepseek.r1-v1:0',
+  'DeepSeek R1 (US)': 'us.deepseek.r1-v1:0',
+
+  // ============================================================
+  // Meta Llama models
+  // ============================================================
   'Llama 3.1 8B Instruct': 'meta.llama3-1-8b-instruct-v1:0',
   'Llama 3.1 70B Instruct': 'meta.llama3-1-70b-instruct-v1:0',
   'Llama 3.1 405B Instruct': 'meta.llama3-1-405b-instruct-v1:0',
+  'Llama 3.2 1B Instruct': 'meta.llama3-2-1b-instruct-v1:0',
+  'Llama 3.2 3B Instruct': 'meta.llama3-2-3b-instruct-v1:0',
+  'Llama 3.2 11B Instruct': 'meta.llama3-2-11b-instruct-v1:0',
+  'Llama 3.2 90B Instruct': 'meta.llama3-2-90b-instruct-v1:0',
+  'Llama 3.3 70B Instruct': 'meta.llama3-3-70b-instruct-v1:0',
+  'Llama 4 Scout 17B Instruct': 'meta.llama4-scout-17b-instruct-v1:0',
+  'Llama 4 Maverick 17B Instruct': 'meta.llama4-maverick-17b-instruct-v1:0',
+  // Meta inference profiles
+  'Llama 3.1 8B Instruct (US)': 'us.meta.llama3-1-8b-instruct-v1:0',
+  'Llama 3.1 70B Instruct (US)': 'us.meta.llama3-1-70b-instruct-v1:0',
+  'Llama 3.1 405B Instruct (US)': 'us.meta.llama3-1-405b-instruct-v1:0',
+  'Llama 3.2 1B Instruct (US)': 'us.meta.llama3-2-1b-instruct-v1:0',
+  'Llama 3.2 1B Instruct (EU)': 'eu.meta.llama3-2-1b-instruct-v1:0',
+  'Llama 3.2 3B Instruct (US)': 'us.meta.llama3-2-3b-instruct-v1:0',
+  'Llama 3.2 3B Instruct (EU)': 'eu.meta.llama3-2-3b-instruct-v1:0',
+  'Llama 3.2 11B Instruct (US)': 'us.meta.llama3-2-11b-instruct-v1:0',
+  'Llama 3.2 90B Instruct (US)': 'us.meta.llama3-2-90b-instruct-v1:0',
+  'Llama 3.3 70B Instruct (US)': 'us.meta.llama3-3-70b-instruct-v1:0',
+  'Llama 4 Scout 17B Instruct (US)': 'us.meta.llama4-scout-17b-instruct-v1:0',
+  'Llama 4 Maverick 17B Instruct (US)':
+    'us.meta.llama4-maverick-17b-instruct-v1:0',
+
+  // ============================================================
   // Mistral AI models
+  // ============================================================
   'Mistral Large': 'mistral.mistral-large-2402-v1:0',
   'Mistral Large 2': 'mistral.mistral-large-2407-v1:0',
   'Mistral Small': 'mistral.mistral-small-2402-v1:0',
+  'Pixtral Large': 'mistral.pixtral-large-2502-v1:0',
+  'Pixtral Large (US)': 'us.mistral.pixtral-large-2502-v1:0',
+  'Pixtral Large (EU)': 'eu.mistral.pixtral-large-2502-v1:0',
 } as const;
 
 export interface InferenceConfiguration {