diff --git a/rptools/rpscore/__main__.py b/rptools/rpscore/__main__.py
index 19df071..ecc9f73 100644
--- a/rptools/rpscore/__main__.py
+++ b/rptools/rpscore/__main__.py
@@ -6,7 +6,10 @@
     Logger,
     getLogger
 )
-from os import path as os_path
+from os import (
+    path as os_path,
+    makedirs as os_makedirs
+)
 from .rpscore import (
     predict_score,
     ThermoError,
@@ -81,6 +84,8 @@ def entry_point():
     # Write results into the pathway
     pathway.set_global_score(score)
     # Write pathway into file
+    # Create the output directory if not exists
+    os_makedirs(os_path.dirname(args.outfile), exist_ok=True)
     pathway.to_rpSBML().write_to_file(
         args.outfile
     )