diff --git a/packages/cli/tests/test_in_workerd.py b/packages/cli/tests/test_in_workerd.py
index e4cf83a..f47f5fa 100644
--- a/packages/cli/tests/test_in_workerd.py
+++ b/packages/cli/tests/test_in_workerd.py
@@ -61,7 +61,7 @@ def test_in_workerd(  # noqa: PLR0913  (too-many-arguments)
     # This is reproducible only in the unittest environment, and doesn't happen
     # when running the same worker manually.
     if (
-        test_dir.name == "sdk"
+        test_dir.name in ("sdk", "entropy-patches")
         and compat_date < "2025-09-29"
         and sys.platform == "linux"
     ):
diff --git a/packages/cli/tests/workerd-test/entropy-patches/entropy-patches.wd-test b/packages/cli/tests/workerd-test/entropy-patches/entropy-patches.wd-test
new file mode 100644
index 0000000..7ada6bc
--- /dev/null
+++ b/packages/cli/tests/workerd-test/entropy-patches/entropy-patches.wd-test
@@ -0,0 +1,18 @@
+using Workerd = import "/workerd/workerd.capnp";
+
+const python :Workerd.Worker = (
+  modules = [
+    (name = "worker.py", pythonModule = embed "worker.py"),
+    %PYTHON_MODULES
+  ],
+  compatibilityDate = "%COMPAT_DATE",
+  compatibilityFlags = ["python_workers", "service_binding_extra_handlers", "enable_python_external_sdk", "python_process_pth_files"],
+);
+
+const unitTests :Workerd.Config = (
+  services = [
+    ( name = "entropy-patches",
+      worker = .python
+    ),
+  ],
+);
diff --git a/packages/cli/tests/workerd-test/entropy-patches/pyproject.toml b/packages/cli/tests/workerd-test/entropy-patches/pyproject.toml
new file mode 100644
index 0000000..f01885a
--- /dev/null
+++ b/packages/cli/tests/workerd-test/entropy-patches/pyproject.toml
@@ -0,0 +1,18 @@
+[project]
+name = "test"
+version = "0.0.0"
+requires-python = ">=3.12"
+dependencies = [
+    "pytest",
+    "pytest-asyncio<1.2.0",
+    "numpy",
+    "pydantic",
+    "requests",
+    "urllib3",
+    "tiktoken",
+    "cryptography",
+    "jiter",
+    "aiohttp",
+    "langsmith",
+    "langchain-openai",
+]
diff --git a/packages/cli/tests/workerd-test/entropy-patches/tests/test_aiohttp_websocket.py b/packages/cli/tests/workerd-test/entropy-patches/tests/test_aiohttp_websocket.py
new file mode 100644
index 0000000..3581cf4
--- /dev/null
+++ b/packages/cli/tests/workerd-test/entropy-patches/tests/test_aiohttp_websocket.py
@@ -0,0 +1,7 @@
+# ruff: noqa: F401
+import aiohttp.http_websocket
+
+
+def test_import():
+    # make sure this file is collected by pytest
+    pass
diff --git a/packages/cli/tests/workerd-test/entropy-patches/tests/test_langsmith.py b/packages/cli/tests/workerd-test/entropy-patches/tests/test_langsmith.py
new file mode 100644
index 0000000..5f00120
--- /dev/null
+++ b/packages/cli/tests/workerd-test/entropy-patches/tests/test_langsmith.py
@@ -0,0 +1,8 @@
+# ruff: noqa: F401
+import langchain_openai.chat_models.base
+import langsmith._internal._constants
+
+
+def test_import():
+    # make sure this file is collected by pytest
+    pass
diff --git a/packages/cli/tests/workerd-test/entropy-patches/tests/test_numpy.py b/packages/cli/tests/workerd-test/entropy-patches/tests/test_numpy.py
new file mode 100644
index 0000000..20f6de6
--- /dev/null
+++ b/packages/cli/tests/workerd-test/entropy-patches/tests/test_numpy.py
@@ -0,0 +1,9 @@
+# ruff: noqa: F401
+import numpy
+import numpy.random
+import numpy.random.mtrand
+
+
+def test_import():
+    # make sure this file is collected by pytest
+    pass
diff --git a/packages/cli/tests/workerd-test/entropy-patches/tests/test_pydantic.py b/packages/cli/tests/workerd-test/entropy-patches/tests/test_pydantic.py
new file mode 100644
index 0000000..64c2bd9
--- /dev/null
+++ b/packages/cli/tests/workerd-test/entropy-patches/tests/test_pydantic.py
@@ -0,0 +1,8 @@
+# ruff: noqa: F401
+import pydantic
+import pydantic_core
+
+
+def test_import():
+    # make sure this file is collected by pytest
+    pass
diff --git a/packages/cli/tests/workerd-test/entropy-patches/tests/test_rust_packages.py b/packages/cli/tests/workerd-test/entropy-patches/tests/test_rust_packages.py
new file mode 100644
index 0000000..bcd522c
--- /dev/null
+++ b/packages/cli/tests/workerd-test/entropy-patches/tests/test_rust_packages.py
@@ -0,0 +1,10 @@
+# ruff: noqa: F401
+
+import cryptography.exceptions
+import jiter
+import tiktoken._tiktoken
+
+
+def test_import():
+    # make sure this file is collected by pytest
+    pass
diff --git a/packages/cli/tests/workerd-test/entropy-patches/tests/test_ssl_avoidance.py b/packages/cli/tests/workerd-test/entropy-patches/tests/test_ssl_avoidance.py
new file mode 100644
index 0000000..21c9729
--- /dev/null
+++ b/packages/cli/tests/workerd-test/entropy-patches/tests/test_ssl_avoidance.py
@@ -0,0 +1,9 @@
+# ruff: noqa: F401
+import aiohttp.connector
+import requests.adapters
+import urllib3.util.ssl_
+
+
+def test_import():
+    # make sure this file is collected by pytest
+    pass
diff --git a/packages/cli/tests/workerd-test/entropy-patches/worker.py b/packages/cli/tests/workerd-test/entropy-patches/worker.py
new file mode 100644
index 0000000..1b0888b
--- /dev/null
+++ b/packages/cli/tests/workerd-test/entropy-patches/worker.py
@@ -0,0 +1,26 @@
+import asyncio
+import os
+import sys
+
+import pytest
+from pyodide.webloop import WebLoop
+from workers import WorkerEntrypoint
+
+
+async def noop(*args):
+    pass
+
+
+# pytest-asyncio relies on these but in Pyodide < 0.29 WebLoop does not implement them
+WebLoop.shutdown_asyncgens = noop
+WebLoop.shutdown_default_executor = noop
+
+if sys.version_info < (3, 13):
+    asyncio.runners._cancel_all_tasks = lambda loop: None  # type: ignore[attr-defined]
+
+
+class Default(WorkerEntrypoint):
+    async def test(self):
+        os.chdir("/session/metadata/tests")
+        args = [".", "-vv"]
+        assert pytest.main(args) == 0
diff --git a/packages/cli/tests/workerd-test/entropy-patches/wrangler.jsonc b/packages/cli/tests/workerd-test/entropy-patches/wrangler.jsonc
new file mode 100644
index 0000000..f89cde9
--- /dev/null
+++ b/packages/cli/tests/workerd-test/entropy-patches/wrangler.jsonc
@@ -0,0 +1,5 @@
+{
+    "name": "test-worker",
+    "compatibility_date": "%COMPAT_DATE",
+    "compatibility_flags": ["python_workers"]
+}