diff --git a/nedrexdb/db/parsers/orphanet.py b/nedrexdb/db/parsers/orphanet.py
new file mode 100644
index 0000000..5da50df
--- /dev/null
+++ b/nedrexdb/db/parsers/orphanet.py
@@ -0,0 +1,149 @@
+from collections import defaultdict as _defaultdict
+from pathlib import Path as _Path
+import xml.etree.cElementTree as _et
+import openpyxl as _openpyxl
+import zipfile as _zipfile
+
+
+from nedrexdb.logger import logger
+from nedrexdb.db.models.nodes.disorder import Disorder
+from nedrexdb.db.models.nodes.gene import Gene
+from nedrexdb.db.models.edges.gene_associated_with_disorder import (
+    GeneAssociatedWithDisorder,
+)
+
+orphanet_path = "https://github.com/Orphanet/Orphadata_aggregated/blob/master/Genes%20associated%20with%20rare%20diseases/en_product*.xml"
+nomenclature_pack = "https://github.com/Orphanet/Orphadata_aggregated/blob/fcb68b2c4b26ace67cc068a2569015c5b156e291/Rare%20diseases%20and%20classifications/Orphanet%20nomenclature%20files%20for%20coding/Orphanet_Nomenclature_Pack_EN.zip"
+
+class OrphanetParser:
+    def __init__(self, orphanet_path, nomenclature_pack):
+        # file for disorder-genes associations
+        self.associations_path = _Path(orphanet_path)
+        if not self.associations_path.exists():
+            raise Exception(f"{self.associations_path} does not exist")
+        # file for Orphacode-icd10 mapping
+        self.nomenclature_path = _Path(nomenclature_pack)
+        if not self.nomenclature_path.exists():
+            raise Exception(f"{self.nomenclature_path} does not exist")
+
+
+    def get_dict_icd10_mondo(self):
+        # get the mapping ICD10 to MONDO from the existing disorders
+        icd10_mondo = _defaultdict(list)
+        for item in Disorder.objects():
+            for icd10_ids in [i for i in item.icd10]:
+                for icd10_id in icd10_ids:
+                    icd10_mondo[icd10_id].append(item.primaryDomainId)
+
+        return icd10_mondo
+
+
+    def get_dict_OrphaCode_icd10(self):
+        target_file_name = "ORPHAnomenclature_MasterFile_*"
+        try:
+            with _zipfile.ZipFile(self.nomenclature_path, 'r') as zip_ref:
+                # Check if the target file is present in the zip archive
+                if target_file_name not in zip_ref.namelist():
+                    print(f"The file '{target_file_name}' was not found in the zip archive.")
+                # Read the content of the specified file
+                with zip_ref.open(target_file_name, 'r') as file:
+                    orpha_icd10 = _defaultdict(list)
+                    workbook = _openpyxl.load_workbook(file)
+                    sheet = workbook.active
+                    # Get header names
+                    headers = [cell.value for cell in sheet[1]]
+                    for row in sheet.iter_rows(min_row=2, values_only=True):
+                        # Assuming the column names are 'orpha' and 'ids'
+                        row_data = dict(zip(headers, row))
+                        # Splitting multiple Orpha codes
+                        orpha = row_data['ORPHAcode']
+                        icd10 = row_data['ICDcodes']
+                        if icd10 != None:
+                            orpha_icd10[orpha].append(icd10)
+
+        except _zipfile.BadZipFile:
+            print(f"The file '{self.nomenclature_path}' is not a valid zip file.")
+
+        return orpha_icd10
+
+
+    def get_OrphaCode(self):
+        depth = 0
+        OrphaCode_list = []
+
+        for event, elem in _et.iterparse(self.associations_path, events=["start", "end"]):
+            if not elem.tag == "OrphaCode":
+                continue
+            if event == "start":
+                depth += 1
+            if event == "end":
+                depth -= 1
+            if depth == 0 and event == "end":
+                OrphaCode_list.append(elem.text)
+
+        return OrphaCode_list
+
+
+    def get_genes(self):
+        list_genes = []
+        depth = 0
+
+        for event, elem in _et.iterparse(self.associations_path, events=["start", "end"]):
+            if not elem.tag == "DisorderGeneAssociationList":
+                continue
+            if event == "start":
+                depth += 1
+            if event == "end":
+                depth -= 1
+            if depth == 0 and event == "end":
+                genes = []
+                if elem.attrib["count"] != 0:
+                    for i in elem.iter('Symbol'):
+                        genes.append(i.text)
+                list_genes.append(genes)
+
+        return list_genes
+
+
+    @logger.catch
+    
+    def parse(self):
+
+        logger.info("Parsing OrphaNet")
+        logger.info("\tParsing disorder-gene associations from OrphaNet")
+
+        orpha_icd10 = self.get_dict_OrphaCode_icd10()
+        icd10_mondo = self.get_dict_icd10_mondo()
+
+        ordered_OrphaCode = self.get_OrphaCode()
+        ordered_associatedGenes = self.get_genes()
+
+        dict_disorder_genes = {}
+        for i in range(len(ordered_OrphaCode)):
+            icd10 = orpha_icd10[ordered_OrphaCode[i]]
+            mondo = icd10_mondo[icd10]
+            dict_disorder_genes[mondo] = ordered_associatedGenes[i]
+
+        for d, gs in dict_disorder_genes.items():
+            for g in gs:
+                # Query to see if a relationship is already recorded.
+                gawd = GeneAssociatedWithDisorder.objects(
+                    sourceDomainId = g,
+                    targetDomainId = d
+                )
+                if not gawd:
+                    # Create it.
+                    gawd = GeneAssociatedWithDisorder(
+                        sourceDomainId = g,
+                        targetDomainId = d,
+                        assertedBy = ["orphanet"]
+                    )
+                    gawd.save()
+                else:
+                    # Check that there is only one result.
+                    assert len(gawd) == 1
+                    gawd = gawd[0]
+                    # Update
+                    gawd.modify(
+                        add_to_set__assertedBy = "orphanet"
+                        )