diff --git a/compiler/packages/babel-plugin-react-compiler/src/ReactiveScopes/CodegenReactiveFunction.ts b/compiler/packages/babel-plugin-react-compiler/src/ReactiveScopes/CodegenReactiveFunction.ts
index 486773d5eb9..b85746965d2 100644
--- a/compiler/packages/babel-plugin-react-compiler/src/ReactiveScopes/CodegenReactiveFunction.ts
+++ b/compiler/packages/babel-plugin-react-compiler/src/ReactiveScopes/CodegenReactiveFunction.ts
@@ -2420,7 +2420,12 @@ function codegenPlace(cx: Context, place: Place): t.Expression | t.JSXText {
     loc: place.loc,
   });
   const identifier = convertIdentifier(place.identifier);
-  identifier.loc = place.loc as any;
+  /*
+   * Guard against GeneratedSource (a Symbol) leaking into Babel AST nodes.
+   * Babel requires Node.loc to be SourceLocation | null, so synthesized nodes
+   * without real source positions must use null, not the internal sentinel.
+   */
+  identifier.loc = place.loc !== GeneratedSource ? (place.loc as t.SourceLocation) : null;
   return identifier;
 }
 
diff --git a/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/bug-generated-source-symbol-in-babel-loc.expect.md b/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/bug-generated-source-symbol-in-babel-loc.expect.md
new file mode 100644
index 00000000000..d2a3d3a946c
--- /dev/null
+++ b/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/bug-generated-source-symbol-in-babel-loc.expect.md
@@ -0,0 +1,180 @@
+
+## Input
+
+```javascript
+// @validatePreserveExistingMemoizationGuarantees
+import {useMemo} from 'react';
+
+function visualFor(state, getLabels) {
+  return {label: getLabels(state), tint: 'red', glyph: () => null};
+}
+
+// Repro: synthesized temporaries for destructured bindings from cross-scope
+// hoisting would have their Babel AST identifier node's .loc set to the
+// internal GeneratedSource Symbol sentinel instead of null, causing
+// v8.serialize / jest-worker IPC failures.
+export function Example({state, getLabels, colors, onTap}) {
+  const session = useMemo(() => ({state}), [state]);
+  if (session.state === 'off') return null;
+
+  const handleTap = () => onTap?.(session.state);
+  const {label, tint, glyph} = visualFor(session.state, getLabels);
+
+  return (
+    <button aria-label={label} onClick={handleTap} style={{background: tint}}>
+      <span>
+        {session.state === 'listening' ? <em>...</em> : glyph(colors.fg)}
+        <span style={{color: colors.fg}}>{label}</span>
+      </span>
+    </button>
+  );
+}
+
+```
+
+## Code
+
+```javascript
+import { c as _c } from "react/compiler-runtime"; // @validatePreserveExistingMemoizationGuarantees
+import { useMemo } from "react";
+
+function visualFor(state, getLabels) {
+  const $ = _c(5);
+  let t0;
+  if ($[0] !== getLabels || $[1] !== state) {
+    t0 = getLabels(state);
+    $[0] = getLabels;
+    $[1] = state;
+    $[2] = t0;
+  } else {
+    t0 = $[2];
+  }
+  let t1;
+  if ($[3] !== t0) {
+    t1 = { label: t0, tint: "red", glyph: _temp };
+    $[3] = t0;
+    $[4] = t1;
+  } else {
+    t1 = $[4];
+  }
+  return t1;
+}
+
+// Repro: synthesized temporaries for destructured bindings from cross-scope
+// hoisting would have their Babel AST identifier node's .loc set to the
+// internal GeneratedSource Symbol sentinel instead of null, causing
+// v8.serialize / jest-worker IPC failures.
+function _temp() {
+  return null;
+}
+export function Example(t0) {
+  const $ = _c(27);
+  const { state, getLabels, colors, onTap } = t0;
+  let t1;
+  if ($[0] !== state) {
+    t1 = { state };
+    $[0] = state;
+    $[1] = t1;
+  } else {
+    t1 = $[1];
+  }
+  const session = t1;
+  if (session.state === "off") {
+    return null;
+  }
+  let t2;
+  if ($[2] !== onTap || $[3] !== session.state) {
+    t2 = () => onTap?.(session.state);
+    $[2] = onTap;
+    $[3] = session.state;
+    $[4] = t2;
+  } else {
+    t2 = $[4];
+  }
+  const handleTap = t2;
+  let label;
+  let t3;
+  let t4;
+  let t5;
+  let t6;
+  if (
+    $[5] !== colors.fg ||
+    $[6] !== getLabels ||
+    $[7] !== handleTap ||
+    $[8] !== session.state
+  ) {
+    const { label: t7, tint, glyph } = visualFor(session.state, getLabels);
+    label = t7;
+    t4 = label;
+    t5 = handleTap;
+    t6 = { background: tint };
+    t3 = session.state === "listening" ? <em>...</em> : glyph(colors.fg);
+    $[5] = colors.fg;
+    $[6] = getLabels;
+    $[7] = handleTap;
+    $[8] = session.state;
+    $[9] = label;
+    $[10] = t3;
+    $[11] = t4;
+    $[12] = t5;
+    $[13] = t6;
+  } else {
+    label = $[9];
+    t3 = $[10];
+    t4 = $[11];
+    t5 = $[12];
+    t6 = $[13];
+  }
+  let t7;
+  if ($[14] !== colors.fg) {
+    t7 = { color: colors.fg };
+    $[14] = colors.fg;
+    $[15] = t7;
+  } else {
+    t7 = $[15];
+  }
+  let t8;
+  if ($[16] !== label || $[17] !== t7) {
+    t8 = <span style={t7}>{label}</span>;
+    $[16] = label;
+    $[17] = t7;
+    $[18] = t8;
+  } else {
+    t8 = $[18];
+  }
+  let t9;
+  if ($[19] !== t3 || $[20] !== t8) {
+    t9 = (
+      <span>
+        {t3}
+        {t8}
+      </span>
+    );
+    $[19] = t3;
+    $[20] = t8;
+    $[21] = t9;
+  } else {
+    t9 = $[21];
+  }
+  let t10;
+  if ($[22] !== t4 || $[23] !== t5 || $[24] !== t6 || $[25] !== t9) {
+    t10 = (
+      <button aria-label={t4} onClick={t5} style={t6}>
+        {t9}
+      </button>
+    );
+    $[22] = t4;
+    $[23] = t5;
+    $[24] = t6;
+    $[25] = t9;
+    $[26] = t10;
+  } else {
+    t10 = $[26];
+  }
+  return t10;
+}
+
+```
+      
+### Eval output
+(kind: exception) Fixture not implemented
\ No newline at end of file
diff --git a/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/bug-generated-source-symbol-in-babel-loc.js b/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/bug-generated-source-symbol-in-babel-loc.js
new file mode 100644
index 00000000000..4b979d8bb76
--- /dev/null
+++ b/compiler/packages/babel-plugin-react-compiler/src/__tests__/fixtures/compiler/bug-generated-source-symbol-in-babel-loc.js
@@ -0,0 +1,27 @@
+// @validatePreserveExistingMemoizationGuarantees
+import {useMemo} from 'react';
+
+function visualFor(state, getLabels) {
+  return {label: getLabels(state), tint: 'red', glyph: () => null};
+}
+
+// Repro: synthesized temporaries for destructured bindings from cross-scope
+// hoisting would have their Babel AST identifier node's .loc set to the
+// internal GeneratedSource Symbol sentinel instead of null, causing
+// v8.serialize / jest-worker IPC failures.
+export function Example({state, getLabels, colors, onTap}) {
+  const session = useMemo(() => ({state}), [state]);
+  if (session.state === 'off') return null;
+
+  const handleTap = () => onTap?.(session.state);
+  const {label, tint, glyph} = visualFor(session.state, getLabels);
+
+  return (
+    <button aria-label={label} onClick={handleTap} style={{background: tint}}>
+      <span>
+        {session.state === 'listening' ? <em>...</em> : glyph(colors.fg)}
+        <span style={{color: colors.fg}}>{label}</span>
+      </span>
+    </button>
+  );
+}