diff --git a/.github/workflows/docker-publish.yml b/.github/workflows/docker-publish.yml
new file mode 100644
index 00000000..a1c96fb0
--- /dev/null
+++ b/.github/workflows/docker-publish.yml
@@ -0,0 +1,54 @@
+name: Build and Publish Docker image
+
+on:
+ push:
+ branches: ["main", "dev"]
+ tags: ["v*"]
+ workflow_dispatch:
+
+permissions:
+ contents: read
+ packages: write
+
+env:
+ REGISTRY: ghcr.io
+ IMAGE_NAME: ${{ github.repository }}
+
+jobs:
+ build-and-push:
+ runs-on: ubuntu-latest
+ steps:
+ - uses: actions/checkout@v6.0.2
+
+ - name: Set up Docker Buildx
+ uses: docker/setup-buildx-action@v4.0.0
+
+ - name: Log in to GitHub Container Registry
+ uses: docker/login-action@v4.1.0
+ with:
+ registry: ${{ env.REGISTRY }}
+ username: ${{ github.actor }}
+ password: ${{ secrets.GITHUB_TOKEN }}
+
+ - name: Extract metadata
+ id: meta
+ uses: docker/metadata-action@v6.0.0
+ with:
+ images: ${{ env.REGISTRY }}/${{ env.IMAGE_NAME }}
+ tags: |
+ type=ref,event=branch
+ type=ref,event=pr
+ type=semver,pattern={{version}}
+ type=semver,pattern={{major}}.{{minor}}
+ type=raw,value=latest,enable={{is_default_branch}}
+ type=raw,value=edge,enable=${{ github.ref == 'refs/heads/dev' }}
+
+ - name: Build and push Docker image
+ uses: docker/build-push-action@v7.1.0
+ with:
+ context: .
+ push: true
+ tags: ${{ steps.meta.outputs.tags }}
+ labels: ${{ steps.meta.outputs.labels }}
+ cache-from: type=gha
+ cache-to: type=gha,mode=max
diff --git a/.github/workflows/nextflow-ci.yml b/.github/workflows/nextflow-ci.yml
index 02b5b968..254ae072 100644
--- a/.github/workflows/nextflow-ci.yml
+++ b/.github/workflows/nextflow-ci.yml
@@ -17,7 +17,7 @@ jobs:
runs-on: ubuntu-latest
steps:
- - uses: actions/checkout@v6
+ - uses: actions/checkout@v6.0.2
- uses: actions/setup-java@v5.2.0
with:
@@ -41,26 +41,13 @@ jobs:
sudo chmod +x /usr/local/bin/nf-test
- name: Lint Nextflow files
- # `nextflow lint` does not load Groovy classes from `lib/`, so it
- # falsely reports `Helpers` as undefined wherever the workflow calls
- # `Helpers.X(...)`. We strip ANSI colour codes from the output, drop
- # those known false-positives, and re-derive the exit status.
+ # Pass -project-dir so that nextflow lint (26.04+) can resolve Groovy
+ # classes from lib/ (e.g. Helpers). Each workflow lives in its own
+ # subdirectory, so lint is invoked once per workflow.
run: |
- tmp=$(mktemp)
- nextflow lint \
- workflows/preproc/preproc_rawtiles.nf \
- workflows/reconst_3d/soct_3d_reconst.nf \
- workflows/reconst_2.5d/soct_2.5d_reconst.nf \
- > "$tmp" 2>&1 || true
- sed 's/\x1b\[[0-9;]*[a-zA-Z]//g' "$tmp" \
- | awk '/`Helpers` is not defined/ { skip = 3; next } skip > 0 { skip--; next } { print }' \
- > "$tmp.filt"
- cat "$tmp.filt"
- if grep -qE '^Error ' "$tmp.filt"; then
- echo "::error::nextflow lint reported errors (excluding Helpers false-positives)"
- exit 1
- fi
- echo "Lint passed (Helpers false-positives ignored: lib/ classes are loaded at runtime but not by 'nextflow lint')."
+ nextflow lint -project-dir workflows/preproc workflows/preproc/preproc_rawtiles.nf
+ nextflow lint -project-dir workflows/reconst_3d workflows/reconst_3d/soct_3d_reconst.nf
+ nextflow lint -project-dir workflows/reconst_2.5d workflows/reconst_2.5d/soct_2.5d_reconst.nf
- name: Validate Nextflow configs
run: |
diff --git a/.github/workflows/publish.yaml b/.github/workflows/publish.yaml
index 295595e0..3f4d6c26 100644
--- a/.github/workflows/publish.yaml
+++ b/.github/workflows/publish.yaml
@@ -3,32 +3,28 @@ name: Build and Publish Toolkit
on:
push:
tags:
- - v1.*
- workflow_dispatch:
+ - "v1.*"
+ workflow_dispatch:
+
+permissions:
+ contents: read
+
jobs:
build_and_publish:
runs-on: ubuntu-latest
steps:
- - uses: actions/checkout@master
- - name: Set up Python 3.10
- uses: actions/setup-python@v3
- with:
- python-version: "3.10"
- - name: Install pypa/build
- run: >-
- python -m
- pip install
- build
- --user
- - name: Build a binary wheel and a source tarball
- run: >-
- python -m
- build
- --sdist
- --wheel
- --outdir dist/
- .
+ - uses: actions/checkout@v6.0.2
+
+ - name: Install uv
+ uses: astral-sh/setup-uv@v8.1.0
+
+ - name: Set up Python 3.14
+ run: uv python install 3.14
+
+ - name: Build sdist and wheel
+ run: uv build --sdist --wheel --out-dir dist/
+
- name: Publish distribution to PyPI
- uses: pypa/gh-action-pypi-publish@release/v1
+ uses: pypa/gh-action-pypi-publish@v1.14.0
with:
password: ${{ secrets.PYPI_TOKEN }}
diff --git a/.github/workflows/python-app.yml b/.github/workflows/python-app.yml
index 575b8810..977d95b3 100644
--- a/.github/workflows/python-app.yml
+++ b/.github/workflows/python-app.yml
@@ -5,33 +5,39 @@ name: Python application
on:
push:
- branches: [ "main" ]
+ branches: ["main", "dev"]
pull_request:
- branches: [ "main" ]
+ branches: ["main", "dev"]
permissions:
contents: read
jobs:
build:
-
runs-on: ubuntu-latest
steps:
- - uses: actions/checkout@v4
- - name: Install uv
- uses: astral-sh/setup-uv@v5
- - name: Set up Python 3.12
- run: uv python install 3.12
- - name: Install dependencies
- run: uv sync
- - name: Lint with ruff
- run: |
- uv run ruff check .
- uv run ruff format --check .
- - name: Type check with ty
- continue-on-error: true
- run: uv run ty check
- - name: Test with pytest
- run: |
- uv run pytest
+ - uses: actions/checkout@v6.0.2
+
+ - name: Install uv
+ uses: astral-sh/setup-uv@v8.1.0
+ with:
+ enable-cache: true
+
+ - name: Set up Python 3.14
+ run: uv python install 3.14
+
+ - name: Install dependencies
+ run: uv sync
+
+ - name: Lint with ruff
+ run: |
+ uv run ruff check .
+ uv run ruff format --check .
+
+ - name: Type check with ty
+ continue-on-error: true
+ run: uv run ty check
+
+ - name: Test with pytest
+ run: uv run pytest
diff --git a/.gitignore b/.gitignore
index 11725bae..589e7e91 100644
--- a/.gitignore
+++ b/.gitignore
@@ -173,6 +173,10 @@ cython_debug/
.nextflow/
*.nextflow.log*
+# nf-test
+.nf-test/
+.nf-test.log
+
# Standalone tools (separate git repos)
tools/
workflows/work/
diff --git a/.pep8speaks.yml b/.pep8speaks.yml
deleted file mode 100644
index 7b47282d..00000000
--- a/.pep8speaks.yml
+++ /dev/null
@@ -1,30 +0,0 @@
-# File : .pep8speaks.yml
-
-scanner:
- diff_only: True # If False, the entire file touched by the Pull Request is scanned for errors. If True, only the diff is scanned.
- linter: pycodestyle # Other option is flake8
-
-pycodestyle: # Same as scanner.linter value. Other option is flake8
- max-line-length: 100 # Default is 79 in PEP 8
- ignore: # Errors and warnings to ignore
- - W504 # line break after binary operator
- - E402 # module level import not at top of file
- - E731 # do not assign a lambda expression, use a def
- - C406 # Unnecessary list literal - rewrite as a dict literal.
- - E741 # ambiguous variable name
-
-no_blank_comment: True # If True, no comment is made on PR without any errors.
-descending_issues_order: False # If True, PEP 8 issues in message will be displayed in descending order of line numbers in the file
-
-message: # Customize the comment made by the bot
- opened: # Messages when a new PR is submitted
- header:
- "Hello @{name}! Thanks for opening this PR. "
- # The keyword {name} is converted into the author's username
- footer:
- "Do see the [Hitchhiker's guide to code style](https://goo.gl/hqbW4r)"
- # The messages can be written as they would over GitHub
- updated: # Messages when new commits are added to the PR
- header: "Hello @{name}! Thanks for updating this PR. "
- footer: "" # Why to comment the link to the style guide everytime? :)
- no_errors: "There are currently no PEP 8 issues detected in this Pull Request. Cheers! :beers: "
diff --git a/.readthedocs.yaml b/.readthedocs.yaml
index fe730638..b2c8cea0 100644
--- a/.readthedocs.yaml
+++ b/.readthedocs.yaml
@@ -6,7 +6,7 @@ version: 2
build:
os: ubuntu-24.04
tools:
- python: "3.12"
+ python: "3.14"
jobs:
create_environment:
- asdf plugin add uv
diff --git a/Dockerfile b/Dockerfile
index 8632c109..bc3e0994 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -1,4 +1,4 @@
-FROM python:3.12
+FROM python:3.14
COPY --from=ghcr.io/astral-sh/uv:latest /uv /uvx /bin/
@@ -19,5 +19,5 @@ RUN apt-get update && apt-get install -y \
# Install with uv
COPY linumpy ./linumpy
COPY scripts ./scripts
-COPY pyproject.toml uv.lock README.md .python-version ./
+COPY pyproject.toml uv.lock README.md ./
RUN uv sync --frozen --no-dev
diff --git a/README.md b/README.md
index 12f66f01..a628877a 100644
--- a/README.md
+++ b/README.md
@@ -7,7 +7,7 @@
## Installation
*Although a version of the library is available on PyPI, it has not been updated in a while. We highly discourage its use.*
-The library is tested for python 3.12. To install the library, clone the repository, change directory to the repository root and then install it with the command below:
+The library is tested for python 3.14. To install the library, clone the repository, change directory to the repository root and then install it with the command below:
```
pip install .
```
diff --git a/docs/NEXTFLOW_WORKFLOWS.md b/docs/NEXTFLOW_WORKFLOWS.md
index 9e5fe1f3..627458ed 100644
--- a/docs/NEXTFLOW_WORKFLOWS.md
+++ b/docs/NEXTFLOW_WORKFLOWS.md
@@ -935,7 +935,7 @@ rm -rf work/
```bash
# Pull container manually
-apptainer pull linumpy.sif docker://ghcr.io/linum/linumpy:latest
+apptainer pull linumpy.sif docker://ghcr.io/linum-uqam/linumpy:latest
# Run with explicit container
nextflow run workflow.nf -with-apptainer linumpy.sif
diff --git a/docs/conf.py b/docs/conf.py
index d69adaaa..8d4fad26 100644
--- a/docs/conf.py
+++ b/docs/conf.py
@@ -2,8 +2,6 @@
# https://www.sphinx-doc.org/en/master/usage/configuration.html
"""Sphinx configuration for the linumpy documentation."""
-from __future__ import annotations
-
import sys
from datetime import datetime
from pathlib import Path
diff --git a/linumpy/cli/args.py b/linumpy/cli/args.py
index 9e7f76b5..8e7b0f01 100644
--- a/linumpy/cli/args.py
+++ b/linumpy/cli/args.py
@@ -1,7 +1,6 @@
"""Common argument-parsing helpers for linumpy CLI scripts."""
import argparse
-import multiprocessing
import os
import shutil
from pathlib import Path
@@ -19,7 +18,7 @@ def get_available_cpus() -> int:
-------
int: Number of available CPUs
"""
- total_cpus = multiprocessing.cpu_count()
+ total_cpus = os.process_cpu_count() or os.cpu_count() or 1
# Check for explicit max CPUs limit
max_cpus = os.environ.get("LINUMPY_MAX_CPUS")
diff --git a/linumpy/config/threads.py b/linumpy/config/threads.py
index 82e9c20b..19fc03d4 100644
--- a/linumpy/config/threads.py
+++ b/linumpy/config/threads.py
@@ -31,7 +31,6 @@
"""
import contextlib
-import multiprocessing
import os
import sys
@@ -39,6 +38,16 @@
_thread_config_applied = False
+def _available_cpus() -> int:
+ """Return the number of CPUs usable by this process.
+
+ Prefers ``os.process_cpu_count()`` (Python 3.13+) which honours
+ ``sched_setaffinity`` and cgroup CPU limits, falling back to
+ ``os.cpu_count()`` and finally to 1.
+ """
+ return os.process_cpu_count() or os.cpu_count() or 1
+
+
def get_max_threads() -> int:
"""
Calculate the maximum number of threads to use based on environment variables.
@@ -47,7 +56,7 @@ def get_max_threads() -> int:
-------
int: Maximum number of threads to use
"""
- total_cpus = multiprocessing.cpu_count()
+ total_cpus = _available_cpus()
# Check for explicit max CPUs limit
max_cpus = os.environ.get("LINUMPY_MAX_CPUS")
@@ -121,7 +130,7 @@ def configure_dask() -> None:
try:
import dask
- max_threads = int(os.environ.get("OMP_NUM_THREADS", multiprocessing.cpu_count()))
+ max_threads = int(os.environ.get("OMP_NUM_THREADS", _available_cpus()))
dask.config.set(num_workers=max_threads)
dask.config.set(scheduler="threads") # Use thread scheduler, not process
dask.config.set({"array.slicing.split_large_chunks": False})
@@ -142,7 +151,7 @@ def configure_sitk() -> None:
try:
import SimpleITK as sitk
- max_threads = int(os.environ.get("OMP_NUM_THREADS", multiprocessing.cpu_count()))
+ max_threads = int(os.environ.get("OMP_NUM_THREADS", _available_cpus()))
sitk.ProcessObject.SetGlobalDefaultNumberOfThreads(max_threads)
except ImportError:
pass
@@ -157,10 +166,10 @@ def configure_torch() -> None:
try:
import torch
- max_threads = int(os.environ.get("OMP_NUM_THREADS", multiprocessing.cpu_count()))
+ max_threads = int(os.environ.get("OMP_NUM_THREADS", _available_cpus()))
torch.set_num_threads(max_threads)
torch.set_num_interop_threads(max_threads)
- except (ImportError, RuntimeError):
+ except ImportError, RuntimeError:
pass
@@ -179,7 +188,7 @@ def apply_threadpool_limits() -> object | None:
from threadpoolctl import threadpool_limits
# Get the configured thread limit
- max_threads = int(os.environ.get("OMP_NUM_THREADS", multiprocessing.cpu_count()))
+ max_threads = int(os.environ.get("OMP_NUM_THREADS", _available_cpus()))
# Apply limits globally - this returns a context manager but also applies immediately
limiter = threadpool_limits(limits=max_threads)
@@ -207,7 +216,7 @@ def configure_all_libraries() -> int:
"""
global _thread_config_applied
- max_threads = int(os.environ.get("OMP_NUM_THREADS", multiprocessing.cpu_count()))
+ max_threads = int(os.environ.get("OMP_NUM_THREADS", _available_cpus()))
# Configure SimpleITK if imported (CRITICAL - major source of CPU spikes)
if "SimpleITK" in sys.modules:
@@ -227,7 +236,7 @@ def configure_all_libraries() -> int:
from numba import set_num_threads
set_num_threads(max_threads)
- except (ImportError, Exception):
+ except ImportError, Exception:
pass
# Apply threadpoolctl limits (catches numpy, scipy, etc.)
@@ -248,8 +257,8 @@ def get_thread_info() -> dict:
dict: Thread configuration information
"""
info = {
- "total_cpus": multiprocessing.cpu_count(),
- "configured_threads": int(os.environ.get("OMP_NUM_THREADS", multiprocessing.cpu_count())),
+ "total_cpus": _available_cpus(),
+ "configured_threads": int(os.environ.get("OMP_NUM_THREADS", _available_cpus())),
"env_vars": {},
"libraries": {},
}
diff --git a/linumpy/geometry/galvo.py b/linumpy/geometry/galvo.py
index e4429936..05d6d0e7 100644
--- a/linumpy/geometry/galvo.py
+++ b/linumpy/geometry/galvo.py
@@ -1,7 +1,5 @@
"""Galvanometric XY shift detection and correction."""
-from __future__ import annotations
-
import numpy as np
from scipy.ndimage import median_filter
diff --git a/linumpy/gpu/__init__.py b/linumpy/gpu/__init__.py
index ee83dc46..c7c63502 100644
--- a/linumpy/gpu/__init__.py
+++ b/linumpy/gpu/__init__.py
@@ -27,6 +27,7 @@
Set USE_GPU=false environment variable to disable GPU globally.
"""
+import operator
import os
import warnings
from typing import Any
@@ -319,7 +320,7 @@ def select_best_gpu(verbose: bool = True) -> Any:
return None
# Find GPU with most free memory
- best_gpu = max(gpus, key=lambda g: g["free_gb"])
+ best_gpu = max(gpus, key=operator.itemgetter("free_gb"))
best_id = best_gpu["id"]
# Switch to best GPU
diff --git a/linumpy/gpu/bias_field.py b/linumpy/gpu/bias_field.py
index 32a76085..45589ea6 100644
--- a/linumpy/gpu/bias_field.py
+++ b/linumpy/gpu/bias_field.py
@@ -5,8 +5,6 @@
CPU (NumPy + SciPy) when ``GPU_AVAILABLE`` is False.
"""
-from __future__ import annotations
-
import numpy as np
from . import GPU_AVAILABLE
diff --git a/linumpy/gpu/bspline.py b/linumpy/gpu/bspline.py
index 32a209ae..ece8235d 100644
--- a/linumpy/gpu/bspline.py
+++ b/linumpy/gpu/bspline.py
@@ -37,8 +37,6 @@
weights regularise short-range support and recover the contrast.
"""
-from __future__ import annotations
-
from typing import Any
import numpy as np
diff --git a/linumpy/gpu/image_quality.py b/linumpy/gpu/image_quality.py
index d362d65a..3958ef62 100644
--- a/linumpy/gpu/image_quality.py
+++ b/linumpy/gpu/image_quality.py
@@ -35,7 +35,7 @@
cupy_uniform_filter = None
-def _to_gpu(arr: np.ndarray) -> "cp.ndarray":
+def _to_gpu(arr: np.ndarray) -> cp.ndarray:
"""Transfer numpy array to GPU."""
return cp.asarray(arr, dtype=cp.float32)
@@ -47,7 +47,7 @@ def _to_cpu(arr: Any) -> np.ndarray:
return np.asarray(arr)
-def normalize_image_gpu(img: "cp.ndarray") -> "cp.ndarray":
+def normalize_image_gpu(img: cp.ndarray) -> cp.ndarray:
"""
Normalize image to [0, 1] range on GPU.
diff --git a/linumpy/gpu/kvikio_zarr.py b/linumpy/gpu/kvikio_zarr.py
index 93a65b49..05fc81b7 100644
--- a/linumpy/gpu/kvikio_zarr.py
+++ b/linumpy/gpu/kvikio_zarr.py
@@ -28,8 +28,6 @@
kvikio falls back to a posix bounce-buffer path with no speed-up.
"""
-from __future__ import annotations
-
import json
import sys
from itertools import product
diff --git a/linumpy/gpu/n4.py b/linumpy/gpu/n4.py
index df491a77..af97da45 100644
--- a/linumpy/gpu/n4.py
+++ b/linumpy/gpu/n4.py
@@ -24,8 +24,6 @@
i.e. ~12 GB for a (256, 1024, 1024) float32 volume.
"""
-from __future__ import annotations
-
from typing import Any
import numpy as np
diff --git a/linumpy/gpu/zarr_io.py b/linumpy/gpu/zarr_io.py
index 43b2e97e..30892857 100644
--- a/linumpy/gpu/zarr_io.py
+++ b/linumpy/gpu/zarr_io.py
@@ -26,8 +26,6 @@
warm cache: kvikio ~9.9 GiB/s, zarr-gpu ~7.1 GiB/s.
"""
-from __future__ import annotations
-
from contextlib import contextmanager
from pathlib import Path
from typing import TYPE_CHECKING, Any, Literal
@@ -65,7 +63,7 @@ def _array_is_kvikio_compatible(array_path: Path) -> bool:
try:
_load_array_spec(array_path)
- except (NotImplementedError, FileNotFoundError, ValueError):
+ except NotImplementedError, FileNotFoundError, ValueError:
return False
return True
@@ -138,7 +136,7 @@ def read_zarr_to_gpu(array_path: str | Path, *, prefer: Backend = "auto") -> Any
try:
return read_zarr_via_kvikio(path)
- except (RuntimeError, OSError, NotImplementedError):
+ except RuntimeError, OSError, NotImplementedError:
pass
return read_zarr_via_zarr_gpu(path)
diff --git a/linumpy/imaging/visualization.py b/linumpy/imaging/visualization.py
index 3476e252..8b6b5fd1 100644
--- a/linumpy/imaging/visualization.py
+++ b/linumpy/imaging/visualization.py
@@ -261,7 +261,7 @@ def _panel_labels_from_orientation(orientation: str) -> tuple | None:
code = orientation.strip("'\" ").upper()
try:
parse_orientation_code(code) # validation only
- except (ValueError, KeyError):
+ except ValueError, KeyError:
return None
a0, a1, a2 = code # anatomical letter for source dim0, dim1, dim2
@@ -415,9 +415,9 @@ def save_annotated_views(
y_slice = y_slice if y_slice is not None else n_cols // 2
# Derive panel titles and axis labels from orientation when available.
- _orient = _panel_labels_from_orientation(orientation) if orientation else None
- if _orient:
- p1_name, p1_xlabel, p1_ylabel, p1_fixed, p2_name, p2_xlabel, p2_ylabel, p2_fixed = _orient
+ orient = _panel_labels_from_orientation(orientation) if orientation else None
+ if orient:
+ p1_name, p1_xlabel, p1_ylabel, p1_fixed, p2_name, p2_xlabel, p2_ylabel, p2_fixed = orient
title1 = f"{p1_name} ({p1_ylabel}\u00d7{p1_xlabel}) view at {p1_fixed}={x_slice}"
title2 = f"{p2_name} ({p2_ylabel}\u00d7{p2_xlabel}) view at {p2_fixed}={y_slice}"
xlabel1, ylabel1 = p1_xlabel, p1_ylabel
diff --git a/linumpy/intensity/bias_field.py b/linumpy/intensity/bias_field.py
index 16cf95b2..4b8d6f78 100644
--- a/linumpy/intensity/bias_field.py
+++ b/linumpy/intensity/bias_field.py
@@ -12,8 +12,6 @@
vol_out, _ = n4_correct(vol_ps, mask)
"""
-from __future__ import annotations
-
import multiprocessing
from typing import Any
diff --git a/linumpy/intensity/normalize.py b/linumpy/intensity/normalize.py
index 188466a8..1be737b5 100644
--- a/linumpy/intensity/normalize.py
+++ b/linumpy/intensity/normalize.py
@@ -221,13 +221,13 @@ def get_smooth_intensity_transition(vol: np.ndarray, slices_start: list[int]) ->
L1 = np.exp(-(2 * z[:, :, 0 : nz / 2] - nz) / (1.0 * nz) * f1)
# If z > N/2
- nz_2 = factor[:, :, nz / 2 : :].shape[2]
+ nz_2 = factor[:, :, nz / 2 :].shape[2]
f2 = np.log((a_next + b_current) / (2.0 * b_current + epsilon))
f2 = np.tile(np.reshape(f2, (nx, ny, 1)), (1, 1, nz_2))
- L2 = np.exp((2 * z[:, :, nz / 2 : :] - nz) / (1.0 * nz) * f2)
+ L2 = np.exp((2 * z[:, :, nz / 2 :] - nz) / (1.0 * nz) * f2)
L[:, :, 0 : nz / 2] = L1
- L[:, :, nz / 2 : :] = L2
+ L[:, :, nz / 2 :] = L2
# Apply correction to this slice
volume[:, :, z1:z2] = L * volume[:, :, z1:z2]
diff --git a/linumpy/io/slice_config.py b/linumpy/io/slice_config.py
index 61f28876..7b259002 100644
--- a/linumpy/io/slice_config.py
+++ b/linumpy/io/slice_config.py
@@ -33,8 +33,6 @@
output path; otherwise the last writer wins.
"""
-from __future__ import annotations
-
import csv
from collections import OrderedDict
from pathlib import Path
diff --git a/linumpy/io/zarr.py b/linumpy/io/zarr.py
index da391567..5c3f731e 100644
--- a/linumpy/io/zarr.py
+++ b/linumpy/io/zarr.py
@@ -201,9 +201,9 @@ def save_omezarr(
metadata = {"method": "ome_zarr.writer.write_image", "version": ome_zarr_version, "args": pyramid_kw}
create_directory(store_path, overwrite)
- _loc = parse_url(store_path, mode="w")
- assert _loc is not None
- store = _loc.store
+ loc = parse_url(store_path, mode="w")
+ assert loc is not None
+ store = loc.store
zarr_group = zarr.group(store=store)
write_image(
@@ -241,9 +241,9 @@ def resolve_omezarr_level_path(zarr_path: Path, level: int = 0) -> Path:
Path
On-disk path of the level's zarr array.
"""
- _zarr_loc = parse_url(zarr_path)
- assert _zarr_loc is not None
- reader = Reader(_zarr_loc)
+ zarr_loc = parse_url(zarr_path)
+ assert zarr_loc is not None
+ reader = Reader(zarr_loc)
nodes = list(reader())
image_node = nodes[0]
@@ -270,9 +270,9 @@ def read_omezarr(zarr_path: Path, level: int = 0) -> tuple:
:type res: tuple (3,)
:return res: Voxel size of zarr array.
"""
- _zarr_loc = parse_url(zarr_path)
- assert _zarr_loc is not None
- reader = Reader(_zarr_loc)
+ zarr_loc = parse_url(zarr_path)
+ assert zarr_loc is not None
+ reader = Reader(zarr_loc)
nodes = list(reader())
image_node = nodes[0]
@@ -402,9 +402,9 @@ def __init__(
else:
raise ValueError(f"Overwrite set to False and {store_path} non-empty.")
- _store_loc = parse_url(store_path, mode="w", fmt=self.fmt)
- assert _store_loc is not None
- store = _store_loc.store
+ store_loc = parse_url(store_path, mode="w", fmt=self.fmt)
+ assert store_loc is not None
+ store = store_loc.store
self.root = zarr.group(store=store)
shape = tuple(int(v) for v in shape)
@@ -536,8 +536,7 @@ def _downsample_to_resolution(
"""Downsample from *source_path* to *target_path* with a specific target shape."""
group_path = str(parent.store_path)
# Remove file:// prefix if present (from zarr URL format)
- if group_path.startswith("file://"):
- group_path = group_path[7:]
+ group_path = group_path.removeprefix("file://")
img_path = parent.store_path / parent.path
image_path = Path(group_path) / parent.path
@@ -648,8 +647,7 @@ def finalize(
# Get the path to level 0 (base resolution) for downsampling source
# Remove file:// prefix if present (from zarr URL format)
group_path = str(self.root.store_path)
- if group_path.startswith("file://"):
- group_path = group_path[7:] # Remove "file://" prefix
+ group_path = group_path.removeprefix("file://") # Remove "file://" prefix
for i, target_um in enumerate(valid_targets):
path = f"{i}"
diff --git a/linumpy/metrics/__init__.py b/linumpy/metrics/__init__.py
index 114a31de..142dff12 100644
--- a/linumpy/metrics/__init__.py
+++ b/linumpy/metrics/__init__.py
@@ -615,13 +615,13 @@ def collect_interface_crop_metrics(
metrics.add_metric("end_index", int(end_idx), unit="voxels", description="End index for cropping")
# Quality checks
- _min_depth = PipelineMetrics.DEFAULT_THRESHOLDS["interface_min_depth_px"]["error"]
- _max_fraction = PipelineMetrics.DEFAULT_THRESHOLDS["interface_max_depth_fraction"]["error"]
- if detected_interface < _min_depth:
+ min_depth = PipelineMetrics.DEFAULT_THRESHOLDS["interface_min_depth_px"]["error"]
+ max_fraction = PipelineMetrics.DEFAULT_THRESHOLDS["interface_max_depth_fraction"]["error"]
+ if detected_interface < min_depth:
metrics.add_metric(
"interface_quality", "warning", description="Interface detected very close to start - may be incorrect"
)
- elif detected_interface > input_shape[0] * _max_fraction:
+ elif detected_interface > input_shape[0] * max_fraction:
metrics.add_metric("interface_quality", "warning", description="Interface detected past halfway - check detection")
else:
metrics.add_metric("interface_quality", "ok", description="Interface detection appears reasonable")
diff --git a/linumpy/microscope/oct.py b/linumpy/microscope/oct.py
index 01934cea..748fb211 100644
--- a/linumpy/microscope/oct.py
+++ b/linumpy/microscope/oct.py
@@ -40,8 +40,7 @@ def read_scan_info(self, filename: Path) -> None:
filename
Path to the scan_file written by the OCT (.txt)
"""
- with Path(filename).open() as f:
- foo = f.read()
+ foo = Path(filename).read_text()
# Process the file input
foo = foo.split("\n")
diff --git a/linumpy/mosaic/discovery.py b/linumpy/mosaic/discovery.py
index 89a67873..92aa8431 100644
--- a/linumpy/mosaic/discovery.py
+++ b/linumpy/mosaic/discovery.py
@@ -101,10 +101,10 @@ def get_mosaic_info(directory: Path, z: int, overlap_fraction: float = 0.2, use_
assert oct_tile is not None
# Compute the mosaic shape
- x_min = min([x for x, _ in tiles_positions_px])
- y_min = min([y for _, y in tiles_positions_px])
- x_max = max([x for x, _ in tiles_positions_px]) + oct_tile.shape[0]
- y_max = max([y for _, y in tiles_positions_px]) + oct_tile.shape[1]
+ x_min = min(x for x, _ in tiles_positions_px)
+ y_min = min(y for _, y in tiles_positions_px)
+ x_max = max(x for x, _ in tiles_positions_px) + oct_tile.shape[0]
+ y_max = max(y for _, y in tiles_positions_px) + oct_tile.shape[1]
mosaic_nrows = x_max - x_min
mosaic_ncols = y_max - y_min
diff --git a/linumpy/mosaic/interpolation.py b/linumpy/mosaic/interpolation.py
index ac932a09..e1068dde 100644
--- a/linumpy/mosaic/interpolation.py
+++ b/linumpy/mosaic/interpolation.py
@@ -26,8 +26,6 @@
``interpolation_failed``, ``interpolation_fallback_reason`` columns).
"""
-from __future__ import annotations
-
import logging
from typing import Any
diff --git a/linumpy/mosaic/motor.py b/linumpy/mosaic/motor.py
index ab34a16d..63acb42d 100644
--- a/linumpy/mosaic/motor.py
+++ b/linumpy/mosaic/motor.py
@@ -232,7 +232,7 @@ def _is_empty(ov: np.ndarray) -> bool:
dy *= scale
refinements["stats"]["clamped_pairs"] += 1
- refinements["horizontal"][(i, j)] = {"dx": float(dx), "dy": float(dy)}
+ refinements["horizontal"][i, j] = {"dx": float(dx), "dy": float(dy)}
refinements["stats"]["valid_pairs"] += 1
all_shifts.append(magnitude)
except Exception as e:
@@ -278,7 +278,7 @@ def _is_empty(ov: np.ndarray) -> bool:
dy *= scale
refinements["stats"]["clamped_pairs"] += 1
- refinements["vertical"][(i, j)] = {"dx": float(dx), "dy": float(dy)}
+ refinements["vertical"][i, j] = {"dx": float(dx), "dy": float(dy)}
refinements["stats"]["valid_pairs"] += 1
all_shifts.append(magnitude)
except Exception as e:
diff --git a/linumpy/mosaic/quick_stitch.py b/linumpy/mosaic/quick_stitch.py
index 07c26a01..82922a1a 100644
--- a/linumpy/mosaic/quick_stitch.py
+++ b/linumpy/mosaic/quick_stitch.py
@@ -110,10 +110,10 @@ def get_mosaic_info(directory: Path, z: int, overlap_fraction: float = 0.2, use_
# Compute the mosaic shape
assert oct_tile is not None
- x_min = min([x for x, _ in tiles_positions_px])
- y_min = min([y for _, y in tiles_positions_px])
- x_max = max([x for x, _ in tiles_positions_px]) + oct_tile.shape[0]
- y_max = max([y for _, y in tiles_positions_px]) + oct_tile.shape[1]
+ x_min = min(x for x, _ in tiles_positions_px)
+ y_min = min(y for _, y in tiles_positions_px)
+ x_max = max(x for x, _ in tiles_positions_px) + oct_tile.shape[0]
+ y_max = max(y for _, y in tiles_positions_px) + oct_tile.shape[1]
mosaic_nrows = x_max - x_min
mosaic_ncols = y_max - y_min
@@ -206,10 +206,10 @@ def quick_stitch(
# Compute the mosaic shape
assert oct_tile is not None
- x_min = min([x for x, _ in tiles_positions_px])
- y_min = min([y for _, y in tiles_positions_px])
- x_max = max([x for x, _ in tiles_positions_px]) + oct_tile.shape[0]
- y_max = max([y for _, y in tiles_positions_px]) + oct_tile.shape[1]
+ x_min = min(x for x, _ in tiles_positions_px)
+ y_min = min(y for _, y in tiles_positions_px)
+ x_max = max(x for x, _ in tiles_positions_px) + oct_tile.shape[0]
+ y_max = max(y for _, y in tiles_positions_px) + oct_tile.shape[1]
mosaic_nrows = x_max - x_min
mosaic_ncols = y_max - y_min
mosaic = np.zeros((mosaic_nrows, mosaic_ncols), dtype=np.float32)
diff --git a/linumpy/reference/allen.py b/linumpy/reference/allen.py
index 9b403992..e1aaf8c6 100644
--- a/linumpy/reference/allen.py
+++ b/linumpy/reference/allen.py
@@ -79,8 +79,7 @@ def download_template(resolution: int, cache: bool = True, cache_dir: str = ".da
# Download the template
response = requests.get(url, stream=True)
with Path(nrrd_file).open("wb") as f:
- for data in tqdm(response.iter_content()):
- f.write(data)
+ f.writelines(tqdm(response.iter_content()))
# Loading the nrrd file
vol = sitk.ReadImage(str(nrrd_file))
diff --git a/linumpy/stack_alignment/io.py b/linumpy/stack_alignment/io.py
index db6d24c3..6f2781e8 100644
--- a/linumpy/stack_alignment/io.py
+++ b/linumpy/stack_alignment/io.py
@@ -34,7 +34,7 @@ def load_shifts_csv(shifts_path: Path) -> tuple[dict, list]:
for _, row in df.iterrows():
fixed_id = int(row["fixed_id"])
moving_id = int(row["moving_id"])
- shift_lookup[(fixed_id, moving_id)] = (row["x_shift_mm"], row["y_shift_mm"])
+ shift_lookup[fixed_id, moving_id] = (row["x_shift_mm"], row["y_shift_mm"])
cumsum = {all_ids[0]: (0.0, 0.0)}
for i in range(len(all_ids) - 1):
@@ -80,7 +80,7 @@ def build_cumulative_shifts(
for _, row in shifts_df.iterrows():
fixed_id = int(row["fixed_id"])
moving_id = int(row["moving_id"])
- shift_lookup[(fixed_id, moving_id)] = (row["x_shift_mm"], row["y_shift_mm"])
+ shift_lookup[fixed_id, moving_id] = (row["x_shift_mm"], row["y_shift_mm"])
all_slice_ids = set()
for _, row in shifts_df.iterrows():
diff --git a/linumpy/tests/test_bias_field.py b/linumpy/tests/test_bias_field.py
index 992b64d7..454184cb 100644
--- a/linumpy/tests/test_bias_field.py
+++ b/linumpy/tests/test_bias_field.py
@@ -1,7 +1,5 @@
"""Tests for linumpy/intensity/bias_field.py (and gpu/bias_field.py)."""
-from __future__ import annotations
-
import numpy as np
import pytest
diff --git a/linumpy/tests/test_bias_field_backend.py b/linumpy/tests/test_bias_field_backend.py
index fe2ed006..a4d7a3a4 100644
--- a/linumpy/tests/test_bias_field_backend.py
+++ b/linumpy/tests/test_bias_field_backend.py
@@ -1,7 +1,5 @@
"""Integration tests for the n4_correct backend dispatcher."""
-from __future__ import annotations
-
import numpy as np
import pytest
diff --git a/linumpy/tests/test_gpu_bspline.py b/linumpy/tests/test_gpu_bspline.py
index 7d02f5c2..353f9a80 100644
--- a/linumpy/tests/test_gpu_bspline.py
+++ b/linumpy/tests/test_gpu_bspline.py
@@ -1,7 +1,5 @@
"""Tests for linumpy.gpu.bspline."""
-from __future__ import annotations
-
import numpy as np
import pytest
diff --git a/linumpy/tests/test_gpu_n4.py b/linumpy/tests/test_gpu_n4.py
index 92802614..f1509fc2 100644
--- a/linumpy/tests/test_gpu_n4.py
+++ b/linumpy/tests/test_gpu_n4.py
@@ -1,7 +1,5 @@
"""Tests for linumpy.gpu.n4."""
-from __future__ import annotations
-
import numpy as np
import pytest
diff --git a/linumpy/tests/test_io_allen.py b/linumpy/tests/test_io_allen.py
index 8155bc1a..4b4d0e9d 100644
--- a/linumpy/tests/test_io_allen.py
+++ b/linumpy/tests/test_io_allen.py
@@ -6,8 +6,6 @@
produces a RAS+ volume (``+X = Right``, ``+Y = Anterior``, ``+Z = Superior``).
"""
-from __future__ import annotations
-
import numpy as np
import pytest
import SimpleITK as sitk
diff --git a/linumpy/tests/test_io_slice_config.py b/linumpy/tests/test_io_slice_config.py
index b054d1d7..717deee4 100644
--- a/linumpy/tests/test_io_slice_config.py
+++ b/linumpy/tests/test_io_slice_config.py
@@ -1,7 +1,5 @@
"""Tests for linumpy/io/slice_config.py."""
-from __future__ import annotations
-
import csv
from pathlib import Path
diff --git a/linumpy/tests/test_n4_gpu_equivalency.py b/linumpy/tests/test_n4_gpu_equivalency.py
index 8c17567e..0bf24530 100644
--- a/linumpy/tests/test_n4_gpu_equivalency.py
+++ b/linumpy/tests/test_n4_gpu_equivalency.py
@@ -26,8 +26,6 @@
a small tolerance.
"""
-from __future__ import annotations
-
import numpy as np
import pytest
diff --git a/linumpy/tests/test_n4_gpu_perf.py b/linumpy/tests/test_n4_gpu_perf.py
index e923c552..9e5e8e2c 100644
--- a/linumpy/tests/test_n4_gpu_perf.py
+++ b/linumpy/tests/test_n4_gpu_perf.py
@@ -6,8 +6,6 @@
seconds, not minutes.
"""
-from __future__ import annotations
-
import time
import numpy as np
diff --git a/pyproject.toml b/pyproject.toml
index a12c823c..74f5b858 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -8,7 +8,7 @@ version = "0.1.1"
description = "linumpy: microscopy tools and utilities"
readme = "README.md"
license = "GPL-3.0-or-later"
-requires-python = ">=3.12"
+requires-python = ">=3.14"
authors = [
{ name = "The LINUM developers" },
]
@@ -21,6 +21,7 @@ classifiers = [
"Intended Audience :: Science/Research",
"Operating System :: OS Independent",
"Programming Language :: Python",
+ "Programming Language :: Python :: 3.14",
"Topic :: Scientific/Engineering",
]
dependencies = [
@@ -199,17 +200,20 @@ include = ["linumpy*", "scripts*"]
# --- Ruff ---
[tool.ruff]
-target-version = "py312"
+target-version = "py314"
line-length = 127
fix = true
include = ["linumpy*", "scripts*"]
[tool.ruff.lint]
select = ["E", "F", "W", "I", "UP", "B", "RUF", "SIM", "C4", "PIE", "PTH",
- "N", "PERF", "FLY", "TCH", "G", "D", "ANN", "ARG", "ERA"]
+ "N", "PERF", "FLY", "G", "D", "ANN", "ARG", "ERA", "FURB"]
# N813: SimpleITK as sitk is the universal Python convention — excluded globally.
# D212/D213 conflict: numpy convention picks D213 (summary on second line of multi-line docstrings).
# ANN401: Any is legitimately unavoidable in a few callback/override signatures.
+# Note: flake8-type-checking (TCH/TC) is intentionally not selected — under
+# PEP 649 (Python 3.14 default), annotations are lazily evaluated, so gating
+# typing-only imports inside TYPE_CHECKING blocks no longer reduces import cost.
ignore = ["N813", "ANN401"]
extend-select = ["D417"]
# Scientific codebase: Greek letters and the info-icon glyph are intentional;
@@ -255,7 +259,7 @@ convention = "numpy"
# before numpy/scipy/SimpleITK or the env vars have no effect.
known-first-party = ["linumpy"]
sections.thread-config = ["linumpy.config.threads"]
-section-order = ["future", "thread-config", "standard-library", "third-party", "first-party", "local-folder"]
+section-order = ["thread-config", "standard-library", "third-party", "first-party", "local-folder"]
[tool.ruff.format]
# Use default (black-compatible) formatting
@@ -265,7 +269,7 @@ section-order = ["future", "thread-config", "standard-library", "third-party", "
include = ["linumpy", "scripts"]
[tool.ty.environment]
-python-version = "3.12"
+python-version = "3.14"
[tool.ty.rules]
# possibly-unresolved-reference defaults to "warn" in ty; raise it to "error"
diff --git a/scripts/diagnostics/linum_aggregate_dilation_analysis.py b/scripts/diagnostics/linum_aggregate_dilation_analysis.py
index 7134eed9..fc17d9c7 100644
--- a/scripts/diagnostics/linum_aggregate_dilation_analysis.py
+++ b/scripts/diagnostics/linum_aggregate_dilation_analysis.py
@@ -234,19 +234,27 @@ def generate_report(stats: Any, corrections: Any, _per_slice: Any, output_dir: P
dev_x = corrections["deviation_from_unity"]["x_percent"]
if abs(dev_y) > 1.0 or abs(dev_x) > 1.0:
- lines.append("⚠ SIGNIFICANT DILATION DETECTED")
- lines.append(f" Y-direction: {abs(dev_y):.2f}% {'contraction' if dev_y > 0 else 'expansion'}")
- lines.append(f" X-direction: {abs(dev_x):.2f}% {'contraction' if dev_x > 0 else 'expansion'}")
- lines.append("")
- lines.append(" This will cause edge misalignment in 3D reconstruction.")
- lines.append(" Apply the recommended correction factors below.")
+ lines.extend(
+ (
+ "⚠ SIGNIFICANT DILATION DETECTED",
+ f" Y-direction: {abs(dev_y):.2f}% {'contraction' if dev_y > 0 else 'expansion'}",
+ f" X-direction: {abs(dev_x):.2f}% {'contraction' if dev_x > 0 else 'expansion'}",
+ "",
+ " This will cause edge misalignment in 3D reconstruction.",
+ " Apply the recommended correction factors below.",
+ )
+ )
else:
lines.append("✓ Scale factors close to 1.0 - minimal dilation detected")
if stats["anisotropy"]["mean"] > 0.01:
- lines.append("")
- lines.append(f"⚠ ANISOTROPIC SCALING: X and Y scales differ by {stats['anisotropy']['mean'] * 100:.2f}%")
- lines.append(" Use different correction factors for X and Y directions.")
+ lines.extend(
+ (
+ "",
+ f"⚠ ANISOTROPIC SCALING: X and Y scales differ by {stats['anisotropy']['mean'] * 100:.2f}%",
+ " Use different correction factors for X and Y directions.",
+ )
+ )
lines.extend(
[
@@ -296,8 +304,7 @@ def generate_report(stats: Any, corrections: Any, _per_slice: Any, output_dir: P
)
report_path = Path(output_dir) / "aggregated_dilation_report.txt"
- with Path(report_path).open("w") as f:
- f.write("\n".join(lines))
+ Path(report_path).write_text("\n".join(lines))
logger.info("Report saved to %s", report_path)
return report_path
diff --git a/scripts/diagnostics/linum_analyze_acquisition_rotation.py b/scripts/diagnostics/linum_analyze_acquisition_rotation.py
index c43b2a14..2c6f8c71 100644
--- a/scripts/diagnostics/linum_analyze_acquisition_rotation.py
+++ b/scripts/diagnostics/linum_analyze_acquisition_rotation.py
@@ -370,8 +370,7 @@ def generate_report(analysis: Any, reg_comparison: Any, output_dir: Path) -> Pat
lines.extend(["", "=" * 70])
report_path = output_dir / "acquisition_rotation_analysis.txt"
- with Path(report_path).open("w") as f:
- f.write("\n".join(lines))
+ Path(report_path).write_text("\n".join(lines))
logger.info("Report saved to %s", report_path)
return report_path
diff --git a/scripts/diagnostics/linum_analyze_registration_transforms.py b/scripts/diagnostics/linum_analyze_registration_transforms.py
index d8526fbe..3f33f16e 100644
--- a/scripts/diagnostics/linum_analyze_registration_transforms.py
+++ b/scripts/diagnostics/linum_analyze_registration_transforms.py
@@ -336,8 +336,7 @@ def generate_report(df: Any, analysis: Any, correlation: Any, output_dir: Path)
lines.append("=" * 70)
report_path = output_dir / "rotation_analysis.txt"
- with Path(report_path).open("w") as f:
- f.write("\n".join(lines))
+ Path(report_path).write_text("\n".join(lines))
logger.info("Report saved to %s", report_path)
return report_path
diff --git a/scripts/diagnostics/linum_analyze_tile_dilation.py b/scripts/diagnostics/linum_analyze_tile_dilation.py
index 389fa90d..f2a3dfe6 100644
--- a/scripts/diagnostics/linum_analyze_tile_dilation.py
+++ b/scripts/diagnostics/linum_analyze_tile_dilation.py
@@ -191,15 +191,27 @@ def generate_report(
if scale_deviation < 0.001:
lines.append("✓ Scale factor ~1.0: No significant dilation detected")
elif scale_factors["mean_scale"] > 1.0:
- lines.append(f"⚠ Scale > 1.0: Tiles spread MORE than expected ({scale_deviation * 100:.2f}% expansion)")
- lines.append(" → Possible cause: Tissue relaxation/expansion after cutting")
+ lines.extend(
+ (
+ f"⚠ Scale > 1.0: Tiles spread MORE than expected ({scale_deviation * 100:.2f}% expansion)",
+ " → Possible cause: Tissue relaxation/expansion after cutting",
+ )
+ )
else:
- lines.append(f"⚠ Scale < 1.0: Tiles spread LESS than expected ({scale_deviation * 100:.2f}% contraction)")
- lines.append(" → Possible cause: Stage calibration error or tissue shrinkage")
+ lines.extend(
+ (
+ f"⚠ Scale < 1.0: Tiles spread LESS than expected ({scale_deviation * 100:.2f}% contraction)",
+ " → Possible cause: Stage calibration error or tissue shrinkage",
+ )
+ )
if scale_factors["anisotropy"] > 0.005:
- lines.append(f"⚠ Anisotropic scaling detected: X/Y scales differ by {scale_factors['anisotropy']:.4f}")
- lines.append(" → May cause edge misalignment in 3D reconstruction")
+ lines.extend(
+ (
+ f"⚠ Anisotropic scaling detected: X/Y scales differ by {scale_factors['anisotropy']:.4f}",
+ " → May cause edge misalignment in 3D reconstruction",
+ )
+ )
lines.extend(
[
@@ -237,8 +249,7 @@ def generate_report(
)
report_path = Path(output_dir) / "dilation_analysis.txt"
- with Path(report_path).open("w") as f:
- f.write("\n".join(lines))
+ Path(report_path).write_text("\n".join(lines))
logger.info("Report saved to %s", report_path)
return report_path
diff --git a/scripts/diagnostics/linum_benchmark_gpu.py b/scripts/diagnostics/linum_benchmark_gpu.py
index 71d0e094..0eee6b10 100644
--- a/scripts/diagnostics/linum_benchmark_gpu.py
+++ b/scripts/diagnostics/linum_benchmark_gpu.py
@@ -57,7 +57,7 @@ class BenchmarkTimer:
def __init__(self) -> None:
self.elapsed = 0
- def __enter__(self) -> "BenchmarkTimer":
+ def __enter__(self) -> BenchmarkTimer:
"""Magic method function."""
self.start = time.perf_counter()
return self
diff --git a/scripts/diagnostics/linum_benchmark_n4_gpu.py b/scripts/diagnostics/linum_benchmark_n4_gpu.py
index 0ecbad8f..399c5e1d 100644
--- a/scripts/diagnostics/linum_benchmark_n4_gpu.py
+++ b/scripts/diagnostics/linum_benchmark_n4_gpu.py
@@ -16,8 +16,6 @@
--live-zarr /scratch/workspace/sub-22/output/01/fix_illumination/mosaic_grid_z01_illum_fix.ome.zarr
"""
-from __future__ import annotations
-
import argparse
import json
import time
@@ -255,7 +253,7 @@ def main():
if args.live_zarr is not None and args.live_zarr.exists():
print(f"\n=== Live OCT volume: {args.live_zarr} (level={args.live_level}) ===")
vol, mask = _load_live_volume(args.live_zarr, level=args.live_level, slice_index=args.live_slice_index)
- zc, yc, xc = (min(s, c) for s, c in zip(vol.shape, args.max_live_shape, strict=True))
+ zc, yc, xc = map(min, vol.shape, args.max_live_shape, strict=True)
vol = vol[:zc, :yc, :xc].copy()
mask = mask[:zc, :yc, :xc].copy()
print(f" live volume shape={vol.shape}, mask coverage={float(mask.mean()):.2%}")
@@ -277,10 +275,12 @@ def main():
json_path.write_text(json.dumps(records, indent=2))
lines = ["# N4 GPU vs SimpleITK benchmark", ""]
- lines.append(
- "| Volume | shrink | iters | CPU (s) | GPU (s) | Speedup | r(bias) | median |Δ|/mean | CV bias CPU | CV bias GPU |"
+ lines.extend(
+ (
+ "| Volume | shrink | iters | CPU (s) | GPU (s) | Speedup | r(bias) | median |Δ|/mean | CV bias CPU | CV bias GPU |",
+ "|---|---|---|---|---|---|---|---|---|---|",
+ )
)
- lines.append("|---|---|---|---|---|---|---|---|---|---|")
for r in records:
shape = "x".join(str(s) for s in r["shape"])
n_iter_str = ",".join(str(n) for n in r["n_iter"])
diff --git a/scripts/diagnostics/linum_diagnose_pipeline.py b/scripts/diagnostics/linum_diagnose_pipeline.py
index b1cecc87..5624789c 100644
--- a/scripts/diagnostics/linum_diagnose_pipeline.py
+++ b/scripts/diagnostics/linum_diagnose_pipeline.py
@@ -21,7 +21,6 @@
import argparse
import glob
import json
-import multiprocessing
import os
import subprocess
import sys
@@ -73,7 +72,7 @@ def check_cpu(self) -> Any:
print_header("CPU Configuration")
# Physical CPU info
- total_cpus = multiprocessing.cpu_count()
+ total_cpus = os.process_cpu_count() or os.cpu_count() or 1
self.results["cpu"]["total_cores"] = total_cpus
print(f" Total CPU cores detected: {total_cpus}")
@@ -170,7 +169,7 @@ def check_gpu(self) -> None:
f"{int(float(parts[2])) / 1024:.1f} GB free"
)
print(f" Driver: {parts[3]}, CUDA: {parts[4]}")
- except (ValueError, IndexError):
+ except ValueError, IndexError:
print(f" ⚠️ Could not parse GPU {i} info: {line}")
self.results["gpu"]["available"] = len(gpus) > 0
diff --git a/scripts/diagnostics/linum_diagnose_reconstruction.py b/scripts/diagnostics/linum_diagnose_reconstruction.py
index f9fd1229..7060a651 100644
--- a/scripts/diagnostics/linum_diagnose_reconstruction.py
+++ b/scripts/diagnostics/linum_diagnose_reconstruction.py
@@ -376,8 +376,7 @@ def generate_summary_report(results: Any, output_dir: Path) -> Path:
lines.extend(["", "=" * 70])
report_path = Path(output_dir) / "diagnostic_report.txt"
- with Path(report_path).open("w") as f:
- f.write("\n".join(lines))
+ Path(report_path).write_text("\n".join(lines))
# Also save JSON
json_path = Path(output_dir) / "diagnostic_results.json"
diff --git a/scripts/diagnostics/linum_n4_gpu_visual_compare.py b/scripts/diagnostics/linum_n4_gpu_visual_compare.py
index b1431377..86d394d5 100644
--- a/scripts/diagnostics/linum_n4_gpu_visual_compare.py
+++ b/scripts/diagnostics/linum_n4_gpu_visual_compare.py
@@ -6,8 +6,6 @@
|CPU - GPU|) for documentation.
"""
-from __future__ import annotations
-
import argparse
from pathlib import Path
@@ -32,7 +30,7 @@ def _load_slab(zarr_path: Path, level: int, z0: int, dz: int):
with zipfile.ZipFile(str(zarr_path)) as zf:
names = zf.namelist()
- top = sorted({n.split("/", 1)[0] for n in names if "/" in n})[0]
+ top = min(n.split("/", 1)[0] for n in names if "/" in n)
root = zarr.open(store, mode="r", path=top)
else:
root = zarr.open(str(zarr_path), mode="r")
diff --git a/scripts/diagnostics/linum_stack_motor_only.py b/scripts/diagnostics/linum_stack_motor_only.py
index 4303b7aa..d9a5f7c7 100644
--- a/scripts/diagnostics/linum_stack_motor_only.py
+++ b/scripts/diagnostics/linum_stack_motor_only.py
@@ -272,7 +272,7 @@ def main() -> None:
# Get resolution from first slice
# NOTE: read_omezarr returns resolution in MILLIMETERS (OME-NGFF standard)
- first_slice_id = sorted(slice_files.keys())[0]
+ first_slice_id = min(slice_files.keys())
_first_vol, first_res = read_omezarr(Path(slice_files[first_slice_id]), level=0)
# Resolution: res is [z, y, x] in mm from OME-NGFF, convert to µm
diff --git a/scripts/diagnostics/linum_stitch_motor_only.py b/scripts/diagnostics/linum_stitch_motor_only.py
index ecae5054..e153cba3 100644
--- a/scripts/diagnostics/linum_stitch_motor_only.py
+++ b/scripts/diagnostics/linum_stitch_motor_only.py
@@ -119,10 +119,10 @@ def main() -> None:
logger.warning(comparison["dilation_warning"])
# Compute output mosaic shape
- posx_min = min([pos[0] for pos in motor_positions])
- posx_max = max([pos[0] + tile_shape[1] for pos in motor_positions])
- posy_min = min([pos[1] for pos in motor_positions])
- posy_max = max([pos[1] + tile_shape[2] for pos in motor_positions])
+ posx_min = min(pos[0] for pos in motor_positions)
+ posx_max = max(pos[0] + tile_shape[1] for pos in motor_positions)
+ posy_min = min(pos[1] for pos in motor_positions)
+ posy_max = max(pos[1] + tile_shape[2] for pos in motor_positions)
mosaic_shape = (volume.shape[0], int(posx_max - posx_min), int(posy_max - posy_min))
logger.info("Output mosaic shape: %s", mosaic_shape)
diff --git a/scripts/linum_aip.py b/scripts/linum_aip.py
index b0d20e17..c3db5735 100644
--- a/scripts/linum_aip.py
+++ b/scripts/linum_aip.py
@@ -39,9 +39,9 @@ def _compute_aip(vol: Any, use_gpu: bool) -> tuple[zarr.Array, tuple]:
shape = vol.shape[1:3]
tile_shape = vol.chunks
zarr_store = create_tempstore(suffix=".zarr")
- _aip = zarr.open(zarr_store, mode="w", shape=shape, dtype=np.float32, chunks=vol.chunks[1:3])
- assert isinstance(_aip, zarr.Array)
- aip = _aip
+ aip_ = zarr.open(zarr_store, mode="w", shape=shape, dtype=np.float32, chunks=vol.chunks[1:3])
+ assert isinstance(aip_, zarr.Array)
+ aip = aip_
nx = vol.shape[1] // tile_shape[1]
ny = vol.shape[2] // tile_shape[2]
diff --git a/scripts/linum_align_to_ras.py b/scripts/linum_align_to_ras.py
index eced9d97..37da2329 100755
--- a/scripts/linum_align_to_ras.py
+++ b/scripts/linum_align_to_ras.py
@@ -331,7 +331,7 @@ def get_pyramid_resolutions_from_zarr(zarr_path: Path) -> list[float] | None:
try:
with Path(metadata_path).open(encoding="utf-8") as f:
metadata = json.load(f)
- except (OSError, json.JSONDecodeError):
+ except OSError, json.JSONDecodeError:
continue
multiscales = metadata.get("multiscales", [])
diff --git a/scripts/linum_analyze_shifts.py b/scripts/linum_analyze_shifts.py
index 03b97e7d..916d2d27 100644
--- a/scripts/linum_analyze_shifts.py
+++ b/scripts/linum_analyze_shifts.py
@@ -114,8 +114,7 @@ def generate_report(df: Any, df_filtered: Any, outlier_mask: Any, stats: Any, re
]
if outlier_mask.sum() > 0:
- report_lines.append("")
- report_lines.append("Outlier shifts:")
+ report_lines.extend(("", "Outlier shifts:"))
shift_mag = np.sqrt(df["x_shift_mm"] ** 2 + df["y_shift_mm"] ** 2)
for idx in df[outlier_mask].index:
row = df.loc[idx]
diff --git a/scripts/linum_apply_slices_transforms.py b/scripts/linum_apply_slices_transforms.py
index dc01fe70..6e9de052 100644
--- a/scripts/linum_apply_slices_transforms.py
+++ b/scripts/linum_apply_slices_transforms.py
@@ -55,9 +55,9 @@ def main() -> None:
parser = _build_arg_parser()
args = parser.parse_args()
- _in = zarr.open(args.in_zarr, mode="r")
- assert isinstance(_in, zarr.Array)
- in_zarr = _in
+ in_ = zarr.open(args.in_zarr, mode="r")
+ assert isinstance(in_, zarr.Array)
+ in_zarr = in_
imin, imax = np.min(np.asarray(in_zarr)), np.max(np.asarray(in_zarr))
checkpoint = np.load(args.in_corrections)
diff --git a/scripts/linum_assess_slice_quality.py b/scripts/linum_assess_slice_quality.py
index d1edb1fd..ec30f15d 100644
--- a/scripts/linum_assess_slice_quality.py
+++ b/scripts/linum_assess_slice_quality.py
@@ -37,8 +37,6 @@
linum_assess_slice_quality.py /path/to/mosaics slice_config.csv --no-use_gpu
"""
-from __future__ import annotations
-
# Configure thread limits before numpy/scipy imports
import linumpy.config.threads # noqa: F401
@@ -261,7 +259,7 @@ def main() -> None:
existing_config = None
if args.update_existing:
- config_to_load = args.existing_config if args.existing_config else output_file
+ config_to_load = args.existing_config or output_file
if Path(config_to_load).exists():
existing_config = read_existing_config(Path(config_to_load))
print(f"Loaded existing config with {len(existing_config)} entries")
diff --git a/scripts/linum_auto_exclude_slices.py b/scripts/linum_auto_exclude_slices.py
index 7df63234..27d4be42 100644
--- a/scripts/linum_auto_exclude_slices.py
+++ b/scripts/linum_auto_exclude_slices.py
@@ -20,6 +20,7 @@
import argparse
import json
import logging
+import operator
import os
import re
from pathlib import Path
@@ -88,7 +89,7 @@ def load_registration_metrics(transforms_dir: Path) -> Any:
if z_corr is not None:
metrics.append((slice_id, float(z_corr)))
- metrics.sort(key=lambda x: x[0])
+ metrics.sort(key=operator.itemgetter(0))
return metrics
diff --git a/scripts/linum_benchmark_kvikio_zarr.py b/scripts/linum_benchmark_kvikio_zarr.py
index 8147d6ff..29847d0b 100755
--- a/scripts/linum_benchmark_kvikio_zarr.py
+++ b/scripts/linum_benchmark_kvikio_zarr.py
@@ -30,8 +30,6 @@
--runs 3
"""
-from __future__ import annotations
-
import argparse
import contextlib
import sys
diff --git a/scripts/linum_convert_tiff_to_omezarr.py b/scripts/linum_convert_tiff_to_omezarr.py
index 2cc734ff..5062a040 100755
--- a/scripts/linum_convert_tiff_to_omezarr.py
+++ b/scripts/linum_convert_tiff_to_omezarr.py
@@ -89,7 +89,7 @@ def check_folders(parser: Any, folder: Path) -> list:
parser.error("No tiff files or subfolder found in the folder.")
else:
logging.info("Found subfolders in the folder.")
- for _index, subfolder in enumerate(subfolders):
+ for subfolder in subfolders:
if not list(Path(subfolder).glob("*.tif")):
parser.error("No tiff files found in the subfolder.")
else:
diff --git a/scripts/linum_detect_rehoming.py b/scripts/linum_detect_rehoming.py
index 52e2f5a2..6307d2f4 100644
--- a/scripts/linum_detect_rehoming.py
+++ b/scripts/linum_detect_rehoming.py
@@ -43,6 +43,7 @@
import argparse
import json
+import operator
from pathlib import Path
import numpy as np
@@ -169,7 +170,7 @@ def _save_diagnostics(
"corrected_y_shift_mm": float(row_after["y_shift_mm"]),
}
)
- records.sort(key=lambda r: r["index"])
+ records.sort(key=operator.itemgetter("index"))
report = {
"n_corrected": len(records),
"corrected_spikes": [r for r in records if r["correction_type"] == "spike"],
diff --git a/scripts/linum_export_manual_align.py b/scripts/linum_export_manual_align.py
index 41d9b8fe..203becb4 100644
--- a/scripts/linum_export_manual_align.py
+++ b/scripts/linum_export_manual_align.py
@@ -372,7 +372,7 @@ def _read_overlap_z_offsets(offsets_file: Path) -> tuple[int, int]:
arr_off = np.loadtxt(str(offsets_file), dtype=int)
if arr_off.size >= 2:
return int(arr_off[0]), int(arr_off[1])
- except (OSError, ValueError):
+ except OSError, ValueError:
pass
return 0, 0
@@ -451,7 +451,7 @@ def main(argv: Any = None) -> None:
interp_remote_dir = (
str(Path(args.interpolated_slices_remote_dir)) if args.interpolated_slices_remote_dir else slices_remote_dir
)
- workers = args.workers or max(1, (os.cpu_count() or 4) - 2)
+ workers = args.workers or max(1, (os.process_cpu_count() or os.cpu_count() or 4) - 2)
overlap_px = args.xy_overlap_px
logger.info("XY overlap slab: %s voxels at pyramid level %s", overlap_px, args.level)
diff --git a/scripts/linum_generate_pipeline_report.py b/scripts/linum_generate_pipeline_report.py
index 0691e7ac..b4acf7c1 100644
--- a/scripts/linum_generate_pipeline_report.py
+++ b/scripts/linum_generate_pipeline_report.py
@@ -27,6 +27,7 @@
except ImportError:
_PIL_AVAILABLE = False
+import operator
from typing import Any
import numpy as np
@@ -177,7 +178,7 @@ def group_issues(issues: list[str]) -> list[dict]:
groups = defaultdict(list)
for issue in issues:
parsed = parse_issue(issue)
- key = parsed["metric"] if parsed["metric"] else "__other__"
+ key = parsed["metric"] or "__other__"
groups[key].append(parsed)
result = []
@@ -330,11 +331,11 @@ def to_svg_y(v: Any) -> Any:
)
# Y-axis labels
- elements.append(
- f'{max_y:.3g}'
- )
- elements.append(
- f'{min_y:.3g}'
+ elements.extend(
+ (
+ f'{max_y:.3g}',
+ f'{min_y:.3g}',
+ )
)
title_text = f"n={len(numeric)}, range [{min_y:.3g}, {max_y:.3g}]"
@@ -360,7 +361,7 @@ def _extract(metrics_list: Any, key: str) -> list:
val = m.get("metrics", {}).get(key, {}).get("value")
if isinstance(val, (int, float)):
pairs.append((src, val))
- pairs.sort(key=lambda p: p[0]) # sort by source file path
+ pairs.sort(key=operator.itemgetter(0)) # sort by source file path
return [v for _, v in pairs]
# XY tile transform: scale and shear across slices
@@ -543,7 +544,7 @@ def _to_float(value: object) -> float | None:
return None
try:
return float(value)
- except (TypeError, ValueError):
+ except TypeError, ValueError:
return None
for r in rows:
@@ -1018,12 +1019,16 @@ def _render_interpolation_section_text(interpolation: dict) -> str:
imp_mean = summary.get("ncc_improvement_mean")
lines = []
- lines.append("")
- lines.append(f"{get_status_emoji('info')} SLICE INTERPOLATION")
- lines.append("-" * 70)
- lines.append(f" Gaps detected : {count}")
- lines.append(f" Successfully interp'd : {n_succeeded}")
- lines.append(f" Hard-skipped (gap) : {n_failed}")
+ lines.extend(
+ (
+ "",
+ f"{get_status_emoji('info')} SLICE INTERPOLATION",
+ "-" * 70,
+ f" Gaps detected : {count}",
+ f" Successfully interp'd : {n_succeeded}",
+ f" Hard-skipped (gap) : {n_failed}",
+ )
+ )
if pre_mean is not None:
lines.append(f" Mean pre-reg NCC : {pre_mean:.3f}")
if post_mean is not None:
@@ -1041,9 +1046,9 @@ def _render_interpolation_section_text(interpolation: dict) -> str:
lines.append(f" Hard-skip reasons : {fb_parts}")
if rows:
- lines.append("")
- lines.append(f" {'Slice':<6} {'Status':<8} {'Used':<14} {'Reason':<28} {'PreNCC':>7} {'PostNCC':>7}")
- lines.append(" " + "-" * 80)
+ lines.extend(
+ ("", f" {'Slice':<6} {'Status':<8} {'Used':<14} {'Reason':<28} {'PreNCC':>7} {'PostNCC':>7}", " " + "-" * 80)
+ )
for r in rows[:50]:
sid = (r.get("slice_id", "") or "?")[:6]
failed = bool(r.get("interpolation_failed"))
@@ -1054,11 +1059,11 @@ def _render_interpolation_section_text(interpolation: dict) -> str:
post = r.get("post_reg_ncc", "")
try:
pre_fmt = f"{float(pre):.3f}" if pre not in ("", None) else "-"
- except (TypeError, ValueError):
+ except TypeError, ValueError:
pre_fmt = "-"
try:
post_fmt = f"{float(post):.3f}" if post not in ("", None) else "-"
- except (TypeError, ValueError):
+ except TypeError, ValueError:
post_fmt = "-"
lines.append(f" {sid:<6} {status:<8} {method_used:<14} {fb:<28} {pre_fmt:>7} {post_fmt:>7}")
if len(rows) > 50:
@@ -1806,41 +1811,49 @@ def generate_text_report(
aggregated = sort_steps(aggregated)
lines = []
- lines.append("=" * 70)
- lines.append(title.center(70))
- lines.append(f"Generated: {datetime.now().strftime('%Y-%m-%d %H:%M:%S')}".center(70))
- lines.append("=" * 70)
- lines.append("")
+ lines.extend(
+ ("=" * 70, title.center(70), f"Generated: {datetime.now().strftime('%Y-%m-%d %H:%M:%S')}".center(70), "=" * 70, "")
+ )
_, error_count, warning_count, ok_count = compute_overall_status(aggregated)
- lines.append("SUMMARY")
- lines.append("-" * 70)
- lines.append(f" Pipeline Steps: {len(aggregated)}")
- lines.append(f" Total Metrics Files: {sum(len(v) for v in aggregated.values())}")
- lines.append(
- f" Status: {get_status_emoji('ok')} OK: {ok_count} "
- f"{get_status_emoji('warning')} Warnings: {warning_count} "
- f"{get_status_emoji('error')} Errors: {error_count}"
+ lines.extend(
+ (
+ "SUMMARY",
+ "-" * 70,
+ f" Pipeline Steps: {len(aggregated)}",
+ f" Total Metrics Files: {sum(len(v) for v in aggregated.values())}",
+ f" Status: {get_status_emoji('ok')} OK: {ok_count} "
+ f"{get_status_emoji('warning')} Warnings: {warning_count} "
+ f"{get_status_emoji('error')} Errors: {error_count}",
+ "",
+ )
)
- lines.append("")
for step_name, metrics_list in aggregated.items():
summary = compute_summary_statistics(metrics_list)
step_status = get_step_status(metrics_list)
- lines.append("")
- lines.append(f"{get_status_emoji(step_status)} {step_name.replace('_', ' ').upper()}")
- lines.append("-" * 70)
- lines.append(f" Items: {summary['count']} | Status: {step_status.upper()}")
+ lines.extend(
+ (
+ "",
+ f"{get_status_emoji(step_status)} {step_name.replace('_', ' ').upper()}",
+ "-" * 70,
+ f" Items: {summary['count']} | Status: {step_status.upper()}",
+ )
+ )
# Quality metrics stats
quality_metrics, _ = separate_metrics_by_type(metrics_list)
if quality_metrics:
- lines.append("")
- lines.append(" Quality Metrics:")
- lines.append(f" {'Metric':<25} {'Mean':>12} {'Median':>12} {'Std':>12} {'Min':>12} {'Max':>12}")
- lines.append(" " + "-" * 77)
+ lines.extend(
+ (
+ "",
+ " Quality Metrics:",
+ f" {'Metric':<25} {'Mean':>12} {'Median':>12} {'Std':>12} {'Min':>12} {'Max':>12}",
+ " " + "-" * 77,
+ )
+ )
for metric_name, mdata in quality_metrics.items():
entries = mdata["entries"]
numeric_vals = [e["value"] for e in entries if isinstance(e.get("value"), (int, float))]
@@ -1859,8 +1872,7 @@ def generate_text_report(
all_warnings, all_errors = collect_issues(metrics_list)
if all_errors:
- lines.append("")
- lines.append(f" {get_status_emoji('error')} ERRORS:")
+ lines.extend(("", f" {get_status_emoji('error')} ERRORS:"))
for g in group_issues(all_errors):
if g["count"] == 1:
lines.append(f" - {g['details'][0]}")
@@ -1870,8 +1882,7 @@ def generate_text_report(
lines.append(f" - {g['metric']}: {g['count']} slices ({val_str})")
if all_warnings:
- lines.append("")
- lines.append(f" {get_status_emoji('warning')} WARNINGS:")
+ lines.extend(("", f" {get_status_emoji('warning')} WARNINGS:"))
for g in group_issues(all_warnings):
if g["count"] == 1:
lines.append(f" - {g['details'][0]}")
@@ -1881,8 +1892,7 @@ def generate_text_report(
lines.append(f" - {g['metric']}: {g['count']} slices ({val_str})")
if verbose:
- lines.append("")
- lines.append(" Individual Results:")
+ lines.extend(("", " Individual Results:"))
for m in metrics_list:
source = extract_slice_id(m.get("source_file", "unknown"))
m_status = m.get("overall_status", "unknown")
@@ -1896,10 +1906,7 @@ def generate_text_report(
if interpolation:
lines.append(_render_interpolation_section_text(interpolation))
- lines.append("")
- lines.append("=" * 70)
- lines.append("End of Report".center(70))
- lines.append("=" * 70)
+ lines.extend(("", "=" * 70, "End of Report".center(70), "=" * 70))
return "\n".join(lines)
@@ -1996,8 +2003,8 @@ def main() -> None:
image_mode=image_mode,
max_overview_width=args.max_overview_width,
max_thumb_width=args.max_thumb_width,
- trends=trends if trends else None,
- diagnostics=diagnostics if diagnostics else None,
+ trends=trends or None,
+ diagnostics=diagnostics or None,
interpolation=interpolation,
)
if output_format == "zip":
@@ -2005,12 +2012,10 @@ def main() -> None:
output_file = output_file.with_suffix(".zip")
generate_zip_bundle(report, images, output_file)
else:
- with Path(output_file).open("w") as f:
- f.write(report)
+ Path(output_file).write_text(report)
else:
report = generate_text_report(aggregated, args.title, args.verbose, interpolation=interpolation)
- with Path(output_file).open("w") as f:
- f.write(report)
+ Path(output_file).write_text(report)
print(f"Report saved to: {output_file}")
diff --git a/scripts/linum_reorient_nifti_to_ras.py b/scripts/linum_reorient_nifti_to_ras.py
index 782df023..6ff760e5 100644
--- a/scripts/linum_reorient_nifti_to_ras.py
+++ b/scripts/linum_reorient_nifti_to_ras.py
@@ -87,9 +87,7 @@ def main() -> None:
# Get the resolution of the original volume
resolutions = img.header["pixdim"][1:4]
new_resolutions = []
- new_resolutions.append(resolutions[axis_lr])
- new_resolutions.append(resolutions[axis_pa])
- new_resolutions.append(resolutions[axis_is])
+ new_resolutions.extend((resolutions[axis_lr], resolutions[axis_pa], resolutions[axis_is]))
# Save the new volume
affine = np.eye(4)
diff --git a/scripts/linum_stack_slices_motor.py b/scripts/linum_stack_slices_motor.py
index 709a8633..bf0a14e8 100644
--- a/scripts/linum_stack_slices_motor.py
+++ b/scripts/linum_stack_slices_motor.py
@@ -383,7 +383,7 @@ def load_registration_transforms(
status = metrics_data.get("overall_status", "ok")
try:
confidence = float(metrics_data["metrics"]["registration_confidence"]["value"])
- except (KeyError, TypeError, ValueError):
+ except KeyError, TypeError, ValueError:
confidence = 1.0 # fallback for older JSONs without confidence score
# Always extract translations and zcorr for accumulation,
@@ -392,11 +392,11 @@ def load_registration_transforms(
try:
metrics_tx = float(metrics_data["metrics"]["translation_x"]["value"])
metrics_ty = float(metrics_data["metrics"]["translation_y"]["value"])
- except (KeyError, TypeError, ValueError):
+ except KeyError, TypeError, ValueError:
metrics_tx, metrics_ty = 0.0, 0.0
try:
metrics_zcorr = float(metrics_data["metrics"]["z_correlation"]["value"])
- except (KeyError, TypeError, ValueError):
+ except KeyError, TypeError, ValueError:
metrics_zcorr = 0.0
all_pairwise_translations[slice_id] = (metrics_tx, metrics_ty, metrics_zcorr)
@@ -404,11 +404,11 @@ def load_registration_transforms(
# Metric-based gating: accept based on z_correlation and rotation
try:
zcorr = float(metrics_data["metrics"]["z_correlation"]["value"])
- except (KeyError, TypeError, ValueError):
+ except KeyError, TypeError, ValueError:
zcorr = 0.0
try:
rot_deg = float(metrics_data["metrics"]["rotation"]["value"])
- except (KeyError, TypeError, ValueError):
+ except KeyError, TypeError, ValueError:
rot_deg = 999.0
if zcorr < load_min_zcorr or abs(rot_deg) > load_max_rotation:
logger.warning(
diff --git a/scripts/linum_stitch_3d.py b/scripts/linum_stitch_3d.py
index 61464214..b9c4c449 100644
--- a/scripts/linum_stitch_3d.py
+++ b/scripts/linum_stitch_3d.py
@@ -76,10 +76,10 @@ def main() -> None:
# Axis-1 of the mosaic is the tile-grid *row* direction (tile_shape[1])
# and axis-2 is the *column* direction (tile_shape[2]); name the bounds
# accordingly so the later `pos[0] -= posr_min` reads naturally.
- posr_min = min([pos[0] for pos in positions])
- posr_max = max([pos[0] + tile_shape[1] for pos in positions])
- posc_min = min([pos[1] for pos in positions])
- posc_max = max([pos[1] + tile_shape[2] for pos in positions])
+ posr_min = min(pos[0] for pos in positions)
+ posr_max = max(pos[0] + tile_shape[1] for pos in positions)
+ posc_min = min(pos[1] for pos in positions)
+ posc_max = max(pos[1] + tile_shape[2] for pos in positions)
mosaic_shape = [volume.shape[0], int(posr_max - posr_min), int(posc_max - posc_min)]
# Stitch the mosaic
diff --git a/scripts/linum_stitch_3d_refined.py b/scripts/linum_stitch_3d_refined.py
index dfc859f8..1f64dd19 100644
--- a/scripts/linum_stitch_3d_refined.py
+++ b/scripts/linum_stitch_3d_refined.py
@@ -136,22 +136,22 @@ def stitch_with_refinements(
# From horizontal neighbor to the left
if j > 0 and (i, j - 1) in refinements.get("horizontal", {}):
- ref = refinements["horizontal"][(i, j - 1)]
+ ref = refinements["horizontal"][i, j - 1]
tile_refinements.append({"dy": -ref["dy"], "dx": -ref["dx"]})
# From horizontal neighbor to the right
if (i, j) in refinements.get("horizontal", {}):
- ref = refinements["horizontal"][(i, j)]
+ ref = refinements["horizontal"][i, j]
tile_refinements.append(ref)
# From vertical neighbor above
if i > 0 and (i - 1, j) in refinements.get("vertical", {}):
- ref = refinements["vertical"][(i - 1, j)]
+ ref = refinements["vertical"][i - 1, j]
tile_refinements.append({"dy": -ref["dy"], "dx": -ref["dx"]})
# From vertical neighbor below
if (i, j) in refinements.get("vertical", {}):
- ref = refinements["vertical"][(i, j)]
+ ref = refinements["vertical"][i, j]
tile_refinements.append(ref)
tile = apply_blend_shift_refinement(tile, tile_refinements)
@@ -162,13 +162,13 @@ def stitch_with_refinements(
tile_refinements = []
if j > 0 and (i, j - 1) in refinements.get("horizontal", {}):
- tile_refinements.append(refinements["horizontal"][(i, j - 1)])
+ tile_refinements.append(refinements["horizontal"][i, j - 1])
if (i, j) in refinements.get("horizontal", {}):
- tile_refinements.append(refinements["horizontal"][(i, j)])
+ tile_refinements.append(refinements["horizontal"][i, j])
if i > 0 and (i - 1, j) in refinements.get("vertical", {}):
- tile_refinements.append(refinements["vertical"][(i - 1, j)])
+ tile_refinements.append(refinements["vertical"][i - 1, j])
if (i, j) in refinements.get("vertical", {}):
- tile_refinements.append(refinements["vertical"][(i, j)])
+ tile_refinements.append(refinements["vertical"][i, j])
if tile_refinements:
avg_dy = np.mean([r["dy"] for r in tile_refinements]) / 2
diff --git a/scripts/linum_view_omezarr.py b/scripts/linum_view_omezarr.py
index e271989b..9033f4aa 100644
--- a/scripts/linum_view_omezarr.py
+++ b/scripts/linum_view_omezarr.py
@@ -27,9 +27,9 @@ def main() -> None:
args = p.parse_args()
# read the image data
- _loc = parse_url(args.input_zarr)
- assert _loc is not None
- reader = Reader(_loc)
+ loc = parse_url(args.input_zarr)
+ assert loc is not None
+ reader = Reader(loc)
# nodes may include images, labels etc
nodes = list(reader())
diff --git a/scripts/tests/test_align_to_ras.py b/scripts/tests/test_align_to_ras.py
index 05626cbd..74df8436 100644
--- a/scripts/tests/test_align_to_ras.py
+++ b/scripts/tests/test_align_to_ras.py
@@ -5,8 +5,6 @@
functions (no ``zarr`` I/O) without relying on the console entry point.
"""
-from __future__ import annotations
-
import importlib.util
from pathlib import Path
diff --git a/uv.lock b/uv.lock
index 4c96bff3..b996754a 100644
--- a/uv.lock
+++ b/uv.lock
@@ -1,10 +1,6 @@
version = 1
revision = 3
-requires-python = ">=3.12"
-resolution-markers = [
- "python_full_version >= '3.13'",
- "python_full_version < '3.13'",
-]
+requires-python = ">=3.14"
[manifest]
overrides = [
@@ -66,40 +62,6 @@ dependencies = [
]
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diff --git a/workflows/preproc/preproc_rawtiles.nf b/workflows/preproc/preproc_rawtiles.nf
index ff400709..a6dbfdbd 100644
--- a/workflows/preproc/preproc_rawtiles.nf
+++ b/workflows/preproc/preproc_rawtiles.nf
@@ -1,6 +1,47 @@
#!/usr/bin/env nextflow
nextflow.enable.dsl = 2
+
+workflow {
+ if (params.use_old_folder_structure) {
+ inputSlices = channel.fromPath("${params.input}/tile_x*_y*_z*/", type: 'dir')
+ .map { path -> tuple(path.toString().substring(path.toString().length() - 2), path) }
+ .groupTuple()
+ }
+ else {
+ inputSlices = channel.fromPath("${params.input}/**/tile_x*_y*_z*/", type: 'dir')
+ .map { path -> tuple(path.toString().substring(path.toString().length() - 2), path) }
+ .groupTuple()
+ }
+ input_dir_channel = channel.fromPath("${params.input}", type: 'dir')
+
+ // Generate a 3D mosaic grid at full resolution
+ create_mosaic_grid(inputSlices)
+
+ // [Optional] Generate AIP images from mosaic grids for QC visualization
+ if (params.generate_aips) {
+ generate_aip(create_mosaic_grid.out)
+ }
+
+ // [Optional] Generate orthogonal view previews of mosaic grids.
+ // maxForks 1 on the process keeps screenshots sequential to avoid spawning
+ // 52 concurrent I/O-heavy jobs. Each task depends only on its own zarr
+ // being complete, which Nextflow already guarantees via channel ordering.
+ if (params.generate_previews) {
+ generate_mosaic_preview(create_mosaic_grid.out)
+ }
+
+ // Estimate XY shifts from metadata
+ estimate_xy_shifts_from_metadata(input_dir_channel)
+
+ // Generate slice configuration file (for controlling which slices to use in reconstruction)
+ if (params.generate_slice_config) {
+ // Combine shifts file with input directory for optional galvo detection
+ slice_config_input = estimate_xy_shifts_from_metadata.out.combine(input_dir_channel)
+ generate_slice_config(slice_config_input)
+ }
+}
+
// Workflow Description
// Convert raw S-OCT tiles into mosaic grids and xy shifts
// Input: Directory containing raw data set tiles
@@ -9,23 +50,25 @@ nextflow.enable.dsl = 2
// Parameters are defined in nextflow.config
process create_mosaic_grid {
- publishDir "${params.output}", mode: 'link' // Hard link: no duplication, file stays accessible
-
+ publishDir "${params.output}", mode: 'link'
+
input:
- tuple val(slice_id), path(tiles)
+ tuple val(slice_id), path(tiles)
+
output:
- tuple val(slice_id), path("*.ome.zarr")
+ tuple val(slice_id), path("*.ome.zarr")
+
script:
- String options = ""
- options += params.fix_galvo_shift? "--fix_galvo_shift":"--no-fix_galvo_shift"
+ def options: String = ""
+ options += params.fix_galvo_shift ? "--fix_galvo_shift" : "--no-fix_galvo_shift"
options += " "
- options += params.fix_camera_shift? "--fix_camera_shift":"--no-fix_camera_shift"
+ options += params.fix_camera_shift ? "--fix_camera_shift" : "--no-fix_camera_shift"
options += " "
- options += params.preprocess? "--preprocess":"--no-preprocess"
+ options += params.preprocess ? "--preprocess" : "--no-preprocess"
// Select GPU or CPU script based on use_gpu parameter
- String gpu_opts = params.use_gpu ? "--use_gpu --galvo_threshold ${params.galvo_confidence_threshold}" : "--no-use_gpu"
+ def gpu_opts: String = params.use_gpu ? "--use_gpu --galvo_threshold ${params.galvo_confidence_threshold}" : "--no-use_gpu"
"""
- linum_create_mosaic_grid_3d.py mosaic_grid_3d_z${slice_id}.ome.zarr --from_tiles_list $tiles --resolution ${params.resolution} --n_processes ${params.processes} --axial_resolution ${params.axial_resolution} --sharding_factor ${params.sharding_factor} ${options} ${gpu_opts}
+ linum_create_mosaic_grid_3d.py mosaic_grid_3d_z${slice_id}.ome.zarr --from_tiles_list ${tiles} --resolution ${params.resolution} --n_processes ${params.processes} --axial_resolution ${params.axial_resolution} --sharding_factor ${params.sharding_factor} ${options} ${gpu_opts}
"""
stub:
@@ -38,11 +81,13 @@ process generate_aip {
publishDir "${params.output}/aips", mode: 'copy'
input:
- tuple val(slice_id), path(mosaic_grid)
+ tuple val(slice_id), path(mosaic_grid)
+
output:
- tuple val(slice_id), path("aip_z${slice_id}.png")
+ tuple val(slice_id), path("aip_z${slice_id}.png")
+
script:
- String gpu_opts = params.use_gpu ? "--use_gpu" : "--no-use_gpu"
+ def gpu_opts: String = params.use_gpu ? "--use_gpu" : "--no-use_gpu"
"""
linum_aip_png.py ${mosaic_grid} aip_z${slice_id}.png ${gpu_opts}
"""
@@ -58,9 +103,11 @@ process generate_mosaic_preview {
publishDir "${params.output}/previews", mode: 'copy'
input:
- tuple val(slice_id), path(mosaic_grid)
+ tuple val(slice_id), path(mosaic_grid)
+
output:
- path("mosaic_grid_z${slice_id}_preview.png")
+ path "mosaic_grid_z${slice_id}_preview.png"
+
script:
"""
linum_screenshot_omezarr.py ${mosaic_grid} mosaic_grid_z${slice_id}_preview.png
@@ -75,10 +122,13 @@ process generate_mosaic_preview {
process estimate_xy_shifts_from_metadata {
cpus params.processes
publishDir "${params.output}", mode: 'copy'
+
input:
- path(input_dir)
+ path input_dir
+
output:
- path("shifts_xy.csv")
+ path "shifts_xy.csv"
+
script:
"""
linum_estimate_xy_shift_from_metadata.py ${input_dir} shifts_xy.csv --n_processes ${params.processes}
@@ -92,16 +142,16 @@ process estimate_xy_shifts_from_metadata {
process generate_slice_config {
publishDir "${params.output}", mode: 'copy'
-
+
input:
- tuple path(shifts_file), path(input_dir)
-
+ tuple path(shifts_file), path(input_dir)
+
output:
- path("slice_config.csv")
-
+ path "slice_config.csv"
+
script:
- String galvo_opts = params.detect_galvo ? "--detect_galvo --tiles_dir ${input_dir} --galvo_threshold ${params.galvo_confidence_threshold}" : ""
- String exclude_first_opt = params.exclude_first_slices > 0 ? "--exclude_first ${params.exclude_first_slices}" : "--exclude_first 0"
+ def galvo_opts: String = params.detect_galvo ? "--detect_galvo --tiles_dir ${input_dir} --galvo_threshold ${params.galvo_confidence_threshold}" : ""
+ def exclude_first_opt: String = params.exclude_first_slices > 0 ? "--exclude_first ${params.exclude_first_slices}" : "--exclude_first 0"
"""
linum_generate_slice_config.py ${shifts_file} slice_config.csv --from_shifts ${exclude_first_opt} ${galvo_opts}
"""
@@ -111,47 +161,3 @@ process generate_slice_config {
printf 'slice_id,use\n' > slice_config.csv
"""
}
-
-
-workflow {
- if (params.use_old_folder_structure)
- {
- inputSlices = channel.fromPath("${params.input}/tile_x*_y*_z*/", type: 'dir')
- .map{path -> tuple(path.toString().substring(path.toString().length() - 2), path)}
- .groupTuple()
- }
- else
- {
- inputSlices = channel.fromPath("${params.input}/**/tile_x*_y*_z*/", type: 'dir')
- .map{path -> tuple(path.toString().substring(path.toString().length() - 2), path)}
- .groupTuple()
- }
- input_dir_channel = channel.fromPath("${params.input}", type: 'dir')
-
- // Generate a 3D mosaic grid at full resolution
- create_mosaic_grid(inputSlices)
-
- // [Optional] Generate AIP images from mosaic grids for QC visualization
- if (params.generate_aips) {
- generate_aip(create_mosaic_grid.out)
- }
-
- // [Optional] Generate orthogonal view previews of mosaic grids.
- // maxForks 1 on the process keeps screenshots sequential to avoid spawning
- // 52 concurrent I/O-heavy jobs. Each task depends only on its own zarr
- // being complete, which Nextflow already guarantees via channel ordering.
- if (params.generate_previews) {
- generate_mosaic_preview(create_mosaic_grid.out)
- }
-
- // Estimate XY shifts from metadata
- estimate_xy_shifts_from_metadata(input_dir_channel)
-
- // Generate slice configuration file (for controlling which slices to use in reconstruction)
- if (params.generate_slice_config) {
- // Combine shifts file with input directory for optional galvo detection
- slice_config_input = estimate_xy_shifts_from_metadata.out
- .combine(input_dir_channel)
- generate_slice_config(slice_config_input)
- }
-}
diff --git a/workflows/reconst_2.5d/soct_2.5d_reconst.nf b/workflows/reconst_2.5d/soct_2.5d_reconst.nf
index 6f0086b5..4eedeb16 100644
--- a/workflows/reconst_2.5d/soct_2.5d_reconst.nf
+++ b/workflows/reconst_2.5d/soct_2.5d_reconst.nf
@@ -1,5 +1,5 @@
#!/usr/bin/env nextflow
-nextflow.enable.dsl=2
+nextflow.enable.dsl = 2
/* S-OCT 2.5D Reconstruction */
/*
@@ -15,179 +15,198 @@ Notes
Add the -resume flag to resume the pipeline from the last successfully completed process.
*/
-params.directory = "."
-params.input_directory = params.directory + "/mosaicgrids"
-params.xy_shift_file = params.directory + "/shifts_xy.csv"
-params.output_directory = params.directory
+params.directory = "."
+params.input_directory = params.directory + "/mosaicgrids"
+params.xy_shift_file = params.directory + "/shifts_xy.csv"
+params.output_directory = params.directory
// Tile shape
-params.tile_nx = 400
-params.tile_ny = 400
-params.spacing_xy = 1.875 // micron
-params.spacing_z = 200.0 // micron
+params.tile_nx = 400
+params.tile_ny = 400
+params.spacing_xy = 1.875
+// micron
+params.spacing_z = 200.0
+// micron
// Tile cropping options
-params.xmin = 10
-params.xmax = 390
-params.ymin = 10
-params.ymax = 390
-params.nx = params.xmax - params.xmin
-params.ny = params.ymax - params.ymin
+params.xmin = 10
+params.xmax = 390
+params.ymin = 10
+params.ymax = 390
+params.nx = params.xmax - params.xmin
+params.ny = params.ymax - params.ymin
// Illumination bias estimation options
-params.illum_n_samples = 512
-params.pos_n_samples = 512
-params.basic_working_size=128
+params.illum_n_samples = 512
+params.pos_n_samples = 512
+params.basic_working_size = 128
// Position Estimation options
-params.initial_overlap = 0.2
+params.initial_overlap = 0.2
// Nifti resampled resolution in microns
-params.resolution_nifti = 10.0
+params.resolution_nifti = 10.0
+
+workflow {
+ // Detect every tile directory
+ slices = channel.fromPath(params.input_directory + "/mosaic_grid_z*.tiff")
+ shifts = channel.fromPath(params.xy_shift_file)
+
+ // Remove compressed stripes caused by the raster scan
+ crop_tiles(slices.flatten())
+
+ // Per-slice illumination bias estimation
+ input_compensation = crop_tiles.out
+ estimate_illumination_bias(input_compensation)
+
+ // Illumination bias compensation
+ compensate_illumination_bias(input_compensation.combine(estimate_illumination_bias.out, by: 0))
+ mosaic_grids_compensated = compensate_illumination_bias.out
+
+ // Estimate the position the tile->position transform
+ estimate_position(mosaic_grids_compensated.map { item -> item[1] }.collect())
+
+ // Apply 2D stitching to all mosaic grids
+ stitch_mosaic(mosaic_grids_compensated.combine(estimate_position.out))
+
+ // Stack the mosaic to get an estimate of the 3D volume
+ stack_mosaic(stitch_mosaic.out.map { item -> item[1] }.collect(), shifts)
+
+ // Compress the stack to zip for transfer
+ compress_stack(stack_mosaic.out)
+
+ // Convert the stack to .ome_zarr format for visualization
+ // FIXME: this process is not working when running with a docker container
+ convert_to_omezarr(stack_mosaic.out)
+
+ // Resample the stack to 10 micron resolution
+ resample_stack(convert_to_omezarr.out)
+}
/* Processes */
// Crop each tile within the mosaic grid.
process crop_tiles {
input:
- path(mosaic_directory)
+ path mosaic_directory
+
output:
- tuple val(mosaic_directory.baseName), path("${mosaic_directory.baseName}_cropped.tiff")
+ tuple val(mosaic_directory.baseName), path("${mosaic_directory.baseName}_cropped.tiff")
+
script:
"""
- linum_crop_tiles.py $mosaic_directory ${mosaic_directory.baseName}_cropped.tiff --xmin ${params.xmin} --xmax ${params.xmax} --ymin ${params.ymin} --ymax ${params.ymax} --tile_shape ${params.tile_nx} ${params.tile_ny}
+ linum_crop_tiles.py ${mosaic_directory} ${mosaic_directory.baseName}_cropped.tiff --xmin ${params.xmin} --xmax ${params.xmax} --ymin ${params.ymin} --ymax ${params.ymax} --tile_shape ${params.tile_nx} ${params.tile_ny}
"""
}
// Estimate the illumination bias affecting each tile, using the BaSIC algorithm.
process estimate_illumination_bias {
input:
- tuple val(key), path(mosaic_grid)
+ tuple val(key), path(mosaic_grid)
+
output:
- tuple val(key), path("${key}_flatfield.nii.gz"), path("${key}_darkfield.nii.gz")
+ tuple val(key), path("${key}_flatfield.nii.gz"), path("${key}_darkfield.nii.gz")
+
script:
"""
- linum_estimate_illumination.py $mosaic_grid ${key}_flatfield.nii.gz --tile_shape ${params.nx} ${params.ny} --output_darkfield ${key}_darkfield.nii.gz
+ linum_estimate_illumination.py ${mosaic_grid} ${key}_flatfield.nii.gz --tile_shape ${params.nx} ${params.ny} --output_darkfield ${key}_darkfield.nii.gz
"""
}
// Compensate the illumination bias affecting each tile, using the BaSIC algorithm.
process compensate_illumination_bias {
input:
- tuple val(key), path(mosaic_grid), path(flatfield), path(darkfield)
+ tuple val(key), path(mosaic_grid), path(flatfield), path(darkfield)
+
output:
- tuple val(key), path("${key}_mosaic_grid_compensated.nii.gz")
+ tuple val(key), path("${key}_mosaic_grid_compensated.nii.gz")
+
script:
"""
- linum_compensate_illumination.py $mosaic_grid ${key}_mosaic_grid_compensated.nii.gz --flatfield $flatfield --darkfield $darkfield --tile_shape ${params.nx} ${params.ny}
+ linum_compensate_illumination.py ${mosaic_grid} ${key}_mosaic_grid_compensated.nii.gz --flatfield ${flatfield} --darkfield ${darkfield} --tile_shape ${params.nx} ${params.ny}
"""
}
// Estimate the tile positions within the mosaic grid.
process estimate_position {
input:
- path mosaic_grids
+ path mosaic_grids
+
output:
- path "position_transform.npy"
+ path "position_transform.npy"
+
script:
"""
- linum_estimate_transform.py $mosaic_grids position_transform.npy --tile_shape ${params.nx} ${params.ny} --initial_overlap ${params.initial_overlap}
+ linum_estimate_transform.py ${mosaic_grids} position_transform.npy --tile_shape ${params.nx} ${params.ny} --initial_overlap ${params.initial_overlap}
"""
}
// Stitch each mosaic grid using the estimated tile positions.
process stitch_mosaic {
input:
- tuple val(key), path(image), path(transform)
+ tuple val(key), path(image), path(transform)
+
output:
- tuple val(key), path("${key}_stitched.nii.gz")
+ tuple val(key), path("${key}_stitched.nii.gz")
+
script:
"""
- linum_stitch_2d.py $image $transform ${key}_stitched.nii.gz --blending_method diffusion --tile_shape ${params.nx} ${params.ny}
+ linum_stitch_2d.py ${image} ${transform} ${key}_stitched.nii.gz --blending_method diffusion --tile_shape ${params.nx} ${params.ny}
"""
}
// Stack the stitched mosaic grids to get a 2.5D reconstruction, using the input xy_shift between images
process stack_mosaic {
input:
- path(images)
- path(xy_shifts)
+ path images
+ path xy_shifts
+
output:
- path "stack.zarr"
+ path "stack.zarr"
+
script:
"""
- linum_stack_slices.py $images stack.zarr --xy_shifts $xy_shifts --resolution_xy ${params.spacing_xy} --resolution_z ${params.spacing_z}
+ linum_stack_slices.py ${images} stack.zarr --xy_shifts ${xy_shifts} --resolution_xy ${params.spacing_xy} --resolution_z ${params.spacing_z}
"""
}
// Convert the stack to nifti
process resample_stack {
input:
- path stack
+ path stack
+
output:
- tuple path("stack_10um.nii.gz")
+ tuple path("stack_10um.nii.gz")
+
script:
"""
- linum_convert_omezarr_to_nifti.py $stack stack_10um.nii.gz --resolution ${params.resolution_nifti}
+ linum_convert_omezarr_to_nifti.py ${stack} stack_10um.nii.gz --resolution ${params.resolution_nifti}
"""
}
// Compress the zarr to zip for transfer
process compress_stack {
input:
- path stack
+ path stack
+
output:
- path "stack.zarr.zip"
+ path "stack.zarr.zip"
+
script:
"""
- zip -r stack.zarr.zip $stack
+ zip -r stack.zarr.zip ${stack}
"""
}
// Convert the stack to .zarr format for visualization
process convert_to_omezarr {
input:
- path stack
+ path stack
+
output:
- path "stack.ome_zarr"
+ path "stack.ome_zarr"
+
script:
"""
- linum_convert_zarr_to_omezarr.py $stack stack.ome_zarr -r ${params.spacing_z} ${params.spacing_xy} ${params.spacing_xy}
+ linum_convert_zarr_to_omezarr.py ${stack} stack.ome_zarr -r ${params.spacing_z} ${params.spacing_xy} ${params.spacing_xy}
"""
}
-
-workflow{
- // Detect every tile directory
- slices = channel.fromPath(params.input_directory + "/mosaic_grid_z*.tiff")
- shifts = channel.fromPath(params.xy_shift_file)
-
- // Remove compressed stripes caused by the raster scan
- crop_tiles(slices.flatten())
-
- // Per-slice illumination bias estimation
- input_compensation=crop_tiles.out
- estimate_illumination_bias(input_compensation)
-
- // Illumination bias compensation
- compensate_illumination_bias(input_compensation.combine(estimate_illumination_bias.out, by:0))
- mosaic_grids_compensated = compensate_illumination_bias.out
-
- // Estimate the position the tile->position transform
- estimate_position(mosaic_grids_compensated.map{ item -> item[1] }.collect())
-
- // Apply 2D stitching to all mosaic grids
- stitch_mosaic(mosaic_grids_compensated.combine(estimate_position.out))
-
- // Stack the mosaic to get an estimate of the 3D volume
- stack_mosaic(stitch_mosaic.out.map{ item -> item[1] }.collect(), shifts)
-
- // Compress the stack to zip for transfer
- compress_stack(stack_mosaic.out)
-
- // Convert the stack to .ome_zarr format for visualization
- // FIXME: this process is not working when running with a docker container
- convert_to_omezarr(stack_mosaic.out)
-
- // Resample the stack to 10 micron resolution
- resample_stack(convert_to_omezarr.out)
-
-}
\ No newline at end of file
diff --git a/workflows/reconst_3d/diagnostics.nf b/workflows/reconst_3d/diagnostics.nf
index 8390562a..9f59c9b5 100644
--- a/workflows/reconst_3d/diagnostics.nf
+++ b/workflows/reconst_3d/diagnostics.nf
@@ -17,7 +17,7 @@ process analyze_rotation_drift {
publishDir "${params.output}/diagnostics/rotation_analysis", mode: 'copy'
input:
- path("register_pairwise/*")
+ path "register_pairwise/*"
output:
path "rotation_analysis/*"
@@ -92,8 +92,8 @@ process stack_motor_only {
publishDir "${params.output}/diagnostics/motor_only_stack", mode: 'copy'
input:
- path("slices/*")
- path(shifts_file)
+ path "slices/*"
+ path shifts_file
output:
path "motor_only_stack.ome.zarr"
@@ -112,8 +112,8 @@ process analyze_acquisition_rotation {
publishDir "${params.output}/diagnostics/acquisition_rotation", mode: 'copy'
input:
- path(shifts_file)
- path("register_pairwise/*")
+ path shifts_file
+ path "register_pairwise/*"
output:
path "acquisition_rotation_analysis/*"
diff --git a/workflows/reconst_3d/soct_3d_reconst.nf b/workflows/reconst_3d/soct_3d_reconst.nf
index a58adb8e..d7b686f8 100644
--- a/workflows/reconst_3d/soct_3d_reconst.nf
+++ b/workflows/reconst_3d/soct_3d_reconst.nf
@@ -23,274 +23,663 @@ nextflow.enable.dsl = 2
// ./diagnostics.nf and are gated below by `params.diagnostic_mode` and
// per-stage flags.
include {
- analyze_rotation_drift;
- stitch_motor_only;
- stitch_refined;
- compare_stitching;
- stack_motor_only;
- analyze_acquisition_rotation;
+ analyze_rotation_drift ;
+ stitch_motor_only ;
+ stitch_refined ;
+ compare_stitching ;
+ stack_motor_only ;
+ analyze_acquisition_rotation
} from './diagnostics.nf'
// =============================================================================
-// PROCESSES
+// MAIN WORKFLOW
// =============================================================================
-// -----------------------------------------------------------------------------
-// Utility Processes
-// -----------------------------------------------------------------------------
-
-process README {
- publishDir { "${params.output}/${task.process}" }, mode: 'move'
+workflow {
+ README()
- output:
- path "readme.txt"
+ def inputDir = Helpers.normalizePath(params.input)
+ def subject_name = Helpers.resolveSubjectName(inputDir, params.subject_name)
+ log.info("Subject: ${subject_name}")
+ log.info("GPU: ${params.use_gpu ? 'ENABLED' : 'DISABLED'}")
- script:
- """
- echo "3D reconstruction pipeline" >> readme.txt
- echo "" >> readme.txt
- echo "[Params]" >> readme.txt
- for p in ${params}; do echo " \$p" >> readme.txt; done
- echo "" >> readme.txt
- echo "[Command-line]" >> readme.txt
- echo "${workflow.commandLine}" >> readme.txt
- echo "" >> readme.txt
- echo "[Configuration files]" >> readme.txt
- for c in ${workflow.configFiles}; do echo " \$c" >> readme.txt; done
- """
+ def debugSlices = Helpers.parseDebugSlices(params.debug_slices)
+ if (debugSlices) {
+ log.info("DEBUG MODE: Processing only slices ${debugSlices.sort().join(', ')}")
+ }
- stub:
- """
- touch readme.txt
- """
-}
+ // Shifts file
+ def shifts_xy_path = params.shifts_xy ?: "${inputDir}/shifts_xy.csv"
+ log.info("Shifts file: ${shifts_xy_path}")
-process analyze_shifts {
- input:
- path(shifts_file)
+ if (!file(shifts_xy_path).exists()) {
+ error(
+ """
+ Shifts file not found: ${shifts_xy_path}
- output:
- path "shifts_analysis/*"
+ Please ensure shifts_xy.csv exists in your input directory,
+ or specify the path with --shifts_xy /path/to/shifts_xy.csv
+ """
+ )
+ }
+ // Value channel — fans out to many consumers; see "Authoring Notes" in
+ // docs/NEXTFLOW_WORKFLOWS.md.
+ shifts_xy = channel.value(file(shifts_xy_path))
- script:
- """
- linum_analyze_shifts.py ${shifts_file} shifts_analysis \
- --resolution ${params.resolution} \
- --iqr_multiplier ${params.outlier_iqr_multiplier}
- """
+ // Slice config (optional)
+ def slice_config_path = params.slice_config ?: Helpers.joinPath(inputDir, "slice_config.csv")
+ def slicesToUse = null
+ if (file(slice_config_path).exists()) {
+ log.info("Slice config: ${slice_config_path}")
+ def parsed = Helpers.parseSliceConfig(slice_config_path)
+ slicesToUse = parsed.use
+ def total = slicesToUse.size() + parsed.excluded.size()
+ log.info("Slice config: ${total} entries (${slicesToUse.size()} included, ${parsed.excluded.size()} excluded)")
+ }
+ else if (params.slice_config) {
+ error("Slice config file not found: ${slice_config_path}")
+ }
- stub:
- """
- mkdir -p shifts_analysis
- touch shifts_analysis/placeholder.txt
- """
-}
+ // Discover input mosaic grids
+ log.info("Looking for mosaic grids in: ${inputDir}")
-process generate_report {
- publishDir "${params.output}", mode: 'copy'
+ def inputDirFile = file(inputDir)
+ def mosaicFiles = inputDirFile
+ .listFiles()
+ .findAll { f -> f.isDirectory() && f.name.startsWith('mosaic_grid') && f.name.endsWith('.ome.zarr') && f.name =~ /z\d+/ }
+ .sort { f -> f.name }
- input:
- tuple path(zarr), path(zip), path(png), path(annotated_png)
- val subject_name
+ if (mosaicFiles.isEmpty()) {
+ error("No mosaic grids found in ${inputDir}. Expected: mosaic_grid*_z00.ome.zarr")
+ }
- output:
- path "${subject_name}_quality_report.${params.report_format ?: 'html'}"
+ def selectedIds = mosaicFiles
+ .collect { f -> Helpers.extractSliceId(f) }
+ .findAll { sid ->
+ if (debugSlices != null) {
+ return debugSlices.contains(sid)
+ }
+ if (slicesToUse != null) {
+ return slicesToUse.contains(sid)
+ }
+ return true
+ }
+ def skippedCount = mosaicFiles.size() - selectedIds.size()
+ if (skippedCount > 0) {
+ def reason = debugSlices != null ? "debug_slices filter" : "slice_config"
+ log.info("Found ${mosaicFiles.size()} mosaic grids; ${selectedIds.size()} selected, ${skippedCount} skipped (${reason})")
+ }
+ else {
+ log.info("Found ${mosaicFiles.size()} mosaic grids; all selected")
+ }
- script:
- def fmt = params.report_format ?: 'html'
- def verbose_flag = params.report_verbose ? "--verbose" : ""
- def overview_arg = png ? "--overview_png ${png}" : ""
- def annotated_arg = annotated_png ? "--annotated_png ${annotated_png}" : ""
- """
- linum_generate_pipeline_report.py ${params.output} ${subject_name}_quality_report.${fmt} \
- --title "Quality Report: ${subject_name}" \
- --format ${fmt} ${verbose_flag} ${overview_arg} ${annotated_arg}
- """
+ inputSlices = channel.fromList(mosaicFiles)
+ .map { f -> Helpers.toSliceTuple(f) }
+ .filter { slice_id, _files ->
+ if (debugSlices != null) {
+ def included = debugSlices.contains(slice_id)
+ if (!included) {
+ log.debug("Skipping slice ${slice_id} (not in debug_slices)")
+ }
+ return included
+ }
+ if (slicesToUse != null) {
+ return slicesToUse.contains(slice_id)
+ }
+ return true
+ }
- stub:
- """
- touch ${subject_name}_quality_report.${params.report_format ?: 'html'}
- """
-}
+ def has_slice_config = file(slice_config_path).exists() || params.auto_assess_quality
+ // Value channel — consumed by auto_assess, common_space, finalise, stack.
+ slice_config_channel = channel.value(
+ file(slice_config_path).exists() ? file(slice_config_path) : file('NO_SLICE_CONFIG')
+ )
-// -----------------------------------------------------------------------------
-// Preprocessing Processes
-// -----------------------------------------------------------------------------
+ if (params.analyze_shifts) {
+ analyze_shifts(shifts_xy)
+ }
-process resample_mosaic_grid {
- input:
- tuple val(slice_id), path(mosaic_grid)
+ // Stage 1: Preprocessing
+ resampled = params.resolution > 0 ? resample_mosaic_grid(inputSlices) : inputSlices
+ focal_fixed = params.fix_curvature_enabled ? fix_focal_curvature(resampled) : resampled
+ illum_fixed = params.fix_illum_enabled ? fix_illumination(focal_fixed) : focal_fixed
- output:
- tuple val(slice_id), path("mosaic_grid_z${slice_id}_resampled.ome.zarr")
+ // Stage 2: XY Stitching (image-registration-based blend refinement)
+ if (params.stitch_global_transform) {
+ pooled_mosaics = illum_fixed.map { _id, p -> p }.collect()
+ estimate_global_transform(pooled_mosaics, slice_config_channel)
+ stitch_inputs = illum_fixed.combine(estimate_global_transform.out.transform)
+ }
+ else {
+ // Value channel so the placeholder can fan out to every per-slice tuple.
+ no_transform = channel.value(file('NO_TRANSFORM'))
+ stitch_inputs = illum_fixed.combine(no_transform)
+ }
+ stitch_3d_with_refinement(stitch_inputs)
+ stitched_slices = stitch_3d_with_refinement.out.stitched
- script:
- def gpu_flag = params.use_gpu ? "--use_gpu" : "--no-use_gpu"
- def gpu_pin_block = Helpers.gpuPinBlock(params, "resample slice=${slice_id}")
- """
- ${gpu_pin_block}
- linum_resample_mosaic_grid.py ${mosaic_grid} "mosaic_grid_z${slice_id}_resampled.ome.zarr" \
- -r ${params.resolution} ${gpu_flag} --n_levels 0 -v
- """
+ if (params.stitch_preview) {
+ generate_stitch_preview(stitched_slices)
+ }
- stub:
- """
- mkdir -p mosaic_grid_z${slice_id}_resampled.ome.zarr
- """
-}
+ // Stage 3: Corrections
+ beam_profile_correction(stitched_slices)
+ crop_interface(beam_profile_correction.out.corrected)
+ normalize(crop_interface.out.cropped)
-process fix_focal_curvature {
- input:
- tuple val(slice_id), path(mosaic_grid)
+ // Stage 3.5: Auto slice quality assessment (optional). Generates a
+ // slice_config.csv that marks degraded slices; an existing static
+ // slice_config.csv is merged so manually-excluded slices stay excluded.
+ // current_slice_config = the latest slice_config as it flows through the
+ // pipeline; rebound by auto_assess / detect_rehoming when each runs.
+ current_slice_config = slice_config_channel
+ if (params.auto_assess_quality) {
+ auto_assess_inputs = normalize.out.normalized
+ .map { _id, norm_path -> norm_path }
+ .collect()
+ auto_assess_quality(auto_assess_inputs, slice_config_channel)
+ current_slice_config = auto_assess_quality.out.slice_config
+ }
- output:
- tuple val(slice_id), path("mosaic_grid_z${slice_id}_focal_fix.ome.zarr")
+ // Stage 4: Common Space Alignment.
+ // detect_rehoming optionally corrects encoder-glitch spikes in the
+ // shifts file and (when a real slice_config exists) stamps
+ // rehomed/rehoming_reliable flags back into it.
+ if (params.detect_rehoming) {
+ detect_rehoming_input = shifts_xy.combine(current_slice_config)
+ detect_rehoming_events(detect_rehoming_input)
+ aligned_shifts = detect_rehoming_events.out.corrected_shifts
+ if (has_slice_config) {
+ current_slice_config = detect_rehoming_events.out.slice_config
+ }
+ }
+ else {
+ aligned_shifts = shifts_xy
+ }
- script:
- def gpu_flag = params.use_gpu ? "--use_gpu" : "--no-use_gpu"
- """
- linum_detect_focal_curvature.py ${mosaic_grid} "mosaic_grid_z${slice_id}_focal_fix.ome.zarr" \\
- --n_levels 0 ${gpu_flag}
- """
+ common_space_input = normalize.out.normalized
+ .toSortedList { a, b -> a[0] <=> b[0] }
+ .flatten()
+ .collate(2)
+ .map { _meta, filename -> filename }
+ .collect()
+ .merge(aligned_shifts) { a, b -> tuple(a, b) }
+ .merge(current_slice_config) { a, b -> tuple(a[0], a[1], b) }
- stub:
- """
- mkdir -p mosaic_grid_z${slice_id}_focal_fix.ome.zarr
- """
-}
+ bring_to_common_space(common_space_input)
-process fix_illumination {
- cpus params.processes
+ slices_common_space = bring_to_common_space.out
+ .flatten()
+ .toSortedList { a, b -> a.getName() <=> b.getName() }
- input:
- tuple val(slice_id), path(mosaic_grid)
+ if (params.common_space_preview) {
+ preview_input = bring_to_common_space.out
+ .flatten()
+ .map { f -> Helpers.toSliceTuple(f) }
+ generate_common_space_preview(preview_input)
+ }
- output:
- tuple val(slice_id), path("mosaic_grid_z${slice_id}_illum_fix.ome.zarr")
+ // Stage 5: Missing Slice Interpolation (optional).
+ // Single-slice gaps (use=false slices already filtered upstream) are
+ // interpolated with zmorph; per-slice diagnostics are merged into
+ // slice_config_final.csv. See docs/SLICE_INTERPOLATION_FEATURE.md.
+ if (params.interpolate_missing_slices) {
+ gaps_channel = slices_common_space
+ .map { sliceList -> [Helpers.detectSingleGaps(sliceList), sliceList] }
+ .flatMap { gapsAndSlices ->
+ def gaps = gapsAndSlices[0]
+ def sliceList = gapsAndSlices[1]
+ if (gaps.isEmpty()) {
+ return []
+ }
+
+ gaps
+ .collect { gap ->
+ def (missingId, beforeId, afterId) = gap
+ def sliceBefore = sliceList.find { f -> f.getName().contains("slice_z${beforeId}") }
+ def sliceAfter = sliceList.find { f -> f.getName().contains("slice_z${afterId}") }
+ (sliceBefore && sliceAfter) ? tuple(missingId, sliceBefore, sliceAfter) : null
+ }
+ .findAll { item -> item != null }
+ }
- script:
- def gpu_flag = params.use_gpu ? "--use_gpu" : "--no-use_gpu"
- """
- linum_fix_illumination_3d.py ${mosaic_grid} "mosaic_grid_z${slice_id}_illum_fix.ome.zarr" \
- --n_processes ${params.processes} \
- --percentile_max ${params.clip_percentile_upper} ${gpu_flag} --n_levels 0
- """
+ interpolate_missing_slice(gaps_channel)
- stub:
- """
- mkdir -p mosaic_grid_z${slice_id}_illum_fix.ome.zarr
- """
+ // Publish slice_config_final.csv as an artifact for the report.
+ // Intentionally NOT piped back into current_slice_config: when no
+ // gaps exist, interpolate_missing_slice does not run and finalise's
+ // output channel is empty, which would in turn empty out
+ // current_slice_config and silently skip stack. Stack only reads
+ // use/auto_excluded — neither column is modified here — so reading
+ // the upstream config is equivalent.
+ if (has_slice_config) {
+ finalise_interpolation(
+ current_slice_config,
+ interpolate_missing_slice.out.manifest.collect(),
+ )
+ }
+
+ all_slices = slices_common_space
+ .mix(interpolate_missing_slice.out.zarr.collect())
+ .flatten()
+ .toSortedList { a, b -> a.getName() <=> b.getName() }
+ }
+ else {
+ all_slices = slices_common_space
+ }
+
+ // Stage 6: Pairwise Registration
+ log.info("Registering slices pairwise")
+
+ fixed_slices = all_slices
+ .map { list -> list.size() > 1 ? list.subList(0, list.size() - 1) : [] }
+ .flatten()
+ moving_slices = all_slices
+ .map { list -> list.size() > 1 ? list.subList(1, list.size()) : [] }
+ .flatten()
+ pairs = fixed_slices.merge(moving_slices)
+
+ register_pairwise(pairs)
+
+ slices_collected = all_slices.flatten().collect()
+ transforms_collected = register_pairwise.out.collect()
+
+ // Stage 6.5: Export manual-alignment package (optional).
+ if (params.export_manual_align) {
+ export_input = slices_collected
+ .combine(transforms_collected)
+ .map { items -> Helpers.partitionSlicesAndTransforms(items) }
+ make_manual_align_package(export_input)
+ }
+
+ // Stage 6.75: Refine manual transforms (optional). Re-runs pairwise
+ // registration initialised from each manual transform; non-manual pairs
+ // are copied unchanged. Refined outputs replace automated transforms.
+ if (params.refine_manual_transforms && params.manual_transforms_dir) {
+ log.info("Refining manual transforms from: ${params.manual_transforms_dir}")
+ // Re-derive pairs from all_slices (value channel, safe to reuse)
+ refine_fixed = all_slices
+ .map { list -> list.size() > 1 ? list.subList(0, list.size() - 1) : [] }
+ .flatten()
+ refine_moving = all_slices
+ .map { list -> list.size() > 1 ? list.subList(1, list.size()) : [] }
+ .flatten()
+ // Key pairs by moving zarr basename (= transform dir name)
+ refine_pairs_keyed = refine_fixed
+ .merge(refine_moving)
+ .map { fixed, moving -> tuple(moving.getName().replace('.ome.zarr', ''), fixed, moving) }
+ // Key auto transform dirs by dir name
+ auto_transforms_keyed = register_pairwise.out
+ .flatten()
+ .filter { f -> !f.getName().endsWith('.ome.zarr') }
+ .map { dir -> tuple(dir.getName(), dir) }
+ // Join pairs with their corresponding auto transform dir
+ refine_input = refine_pairs_keyed
+ .join(auto_transforms_keyed)
+ .map { _id, fixed, moving, auto_tfm -> tuple(fixed, moving, auto_tfm) }
+ refine_manual_transforms(refine_input)
+ transforms_for_stack = refine_manual_transforms.out.collect()
+ }
+ else {
+ transforms_for_stack = transforms_collected
+ }
+
+ // Stage 7: Stacking
+ log.info("Stacking slices with registration refinements")
+
+ // Auto-exclude: detect clusters of consecutive low-quality registrations.
+ // Stamps auto_excluded/auto_exclude_reason into slice_config so stack
+ // sees them via --slice_config. Requires a real slice_config.
+ stack_slice_config = current_slice_config
+ if (params.auto_exclude_enabled && has_slice_config) {
+ auto_exclude_slices(transforms_for_stack, current_slice_config)
+ stack_slice_config = auto_exclude_slices.out.slice_config
+ }
+
+ // Build stack_input with `merge` (preserves list-vs-file structure of each
+ // input). Earlier versions used `combine`, which flattens lists into a
+ // single tuple and forced fragile filename-based dispatch in `.map`.
+ stack_input = slices_collected
+ .merge(shifts_xy) { s, x -> tuple(s, x) }
+ .merge(transforms_for_stack) { acc, t -> tuple(acc[0], acc[1], t) }
+ .merge(stack_slice_config) { acc, sc -> tuple(acc[0], acc[1], acc[2], sc) }
+ .map { slices, shifts, transforms, sc ->
+ tuple(slices, shifts, transforms, sc, subject_name, Helpers.extractSliceIdsString(slices))
+ }
+
+ stack(stack_input)
+ stack_output = stack.out.volume
+ stack_metadata = stack_input.map { _slices, _shifts, _transforms, _sc, name, ids_str ->
+ tuple(name, ids_str.split(',').size(), ids_str)
+ }
+
+ // Stage 8: Bias Field Correction (optional)
+ if (params.correct_bias_field) {
+ log.info("Running N4 bias field correction (mode=${params.bias_mode})")
+ znorm_input = stack_output
+ .combine(stack_metadata)
+ .map { zarr, _zip, _png, _annotated, name, n, ids_str -> tuple(zarr, name, n, ids_str) }
+ correct_bias_field(znorm_input)
+ final_stack_output = correct_bias_field.out
+ }
+ else {
+ final_stack_output = stack_output
+ }
+
+ // Stage 9: Report Generation (optional)
+ if (params.generate_report) {
+ generate_report(final_stack_output, subject_name)
+ }
+
+ // Stage 10: Atlas Registration (optional)
+ if (params.align_to_ras_enabled) {
+ log.info("Registering to Allen Mouse Brain Atlas (RAS alignment)")
+ align_to_ras(final_stack_output, subject_name)
+ }
+
+ // Stage 11: Diagnostics (optional). Toggle individually or via diagnostic_mode.
+ if (params.diagnostic_mode) {
+ log.info("DIAGNOSTIC MODE enabled (acq rotation, rotation drift, motor-only stitch/stack)")
+ }
+
+ if (Helpers.diagEnabled(params, 'analyze_acquisition_rotation')) {
+ analyze_acquisition_rotation(shifts_xy, register_pairwise.out.collect())
+ }
+
+ if (Helpers.diagEnabled(params, 'analyze_rotation_drift')) {
+ analyze_rotation_drift(register_pairwise.out.collect())
+ }
+
+ if (Helpers.diagEnabled(params, 'motor_only_stack')) {
+ motor_only_stack_input = normalize.out.normalized
+ .map { _id, slice_file -> slice_file }
+ .collect()
+ stack_motor_only(motor_only_stack_input, shifts_xy)
+ }
+
+ // motor_only_stitch is also a prerequisite for compare_stitching, so run it
+ // whenever either is requested. A second `stitch_motor_only(illum_fixed)`
+ // call would emit the same channel twice, which Nextflow forbids.
+ def runMotorStitch = Helpers.diagEnabled(params, 'motor_only_stitch')
+ def runComparison = params.compare_stitching || params.diagnostic_mode
+ if (runMotorStitch || runComparison) {
+ stitch_motor_only(illum_fixed)
+ }
+
+ if (runComparison) {
+ log.info("Running stitching comparison (motor-only vs refined)...")
+
+ stitch_refined(illum_fixed)
+
+ motor_stitch_with_id = stitch_motor_only.out.map { f -> Helpers.toSliceTuple(f) }
+ refined_stitch_with_id = stitch_refined.out[0].map { f -> Helpers.toSliceTuple(f) }
+
+ comparison_input = motor_stitch_with_id.combine(refined_stitch_with_id, by: 0)
+
+ compare_stitching(comparison_input)
+ }
}
+// =============================================================================
+// PROCESSES
+// =============================================================================
+
// -----------------------------------------------------------------------------
-// Stitching Processes
+// Utility Processes
// -----------------------------------------------------------------------------
-process estimate_global_transform {
- input:
- path("pool_input/*")
- path(slice_config)
+process README {
+ publishDir { "${params.output}/${task.process}" }, mode: 'move'
output:
- path("global_affine.npy"), emit: transform
- path("global_affine.json"), optional: true, emit: diagnostics
+ path "readme.txt"
script:
- def slice_config_arg = slice_config.name != 'NO_SLICE_CONFIG' ? "--slice_config ${slice_config}" : ""
- def histogram_arg = params.stitch_global_transform_histogram_match ? "--histogram_match" : ""
- def empty_arg = params.stitch_global_transform_max_empty_fraction != null
- ? "--max_empty_fraction ${params.stitch_global_transform_max_empty_fraction}"
- : ""
- def n_samples_arg = (params.stitch_global_transform_n_samples as int) > 0
- ? "--n_samples ${params.stitch_global_transform_n_samples as int}"
- : ""
- def include_arg = params.stitch_global_transform_slices?.trim()
- ? "--include_slice " + params.stitch_global_transform_slices.toString().split('[,\\s]+').join(' ')
- : ""
- def gpu_flag = params.use_gpu ? "--use_gpu" : "--no-use_gpu"
"""
- linum_estimate_global_transform.py pool_input global_affine.npy \
- --overlap_fraction ${params.stitch_overlap_fraction} \
- ${slice_config_arg} \
- ${include_arg} \
- ${histogram_arg} \
- ${empty_arg} \
- ${n_samples_arg} \
- --seed ${params.stitch_global_transform_seed} \
- --diagnostics_json global_affine.json \
- -f ${gpu_flag}
+ echo "3D reconstruction pipeline" >> readme.txt
+ echo "" >> readme.txt
+ echo "[Params]" >> readme.txt
+ for p in ${params}; do echo " \$p" >> readme.txt; done
+ echo "" >> readme.txt
+ echo "[Command-line]" >> readme.txt
+ echo "${workflow.commandLine}" >> readme.txt
+ echo "" >> readme.txt
+ echo "[Configuration files]" >> readme.txt
+ for c in ${workflow.configFiles}; do echo " \$c" >> readme.txt; done
"""
stub:
"""
- touch global_affine.npy
- touch global_affine.json
+ touch readme.txt
"""
}
-process stitch_3d_with_refinement {
- publishDir { "${params.output}/${task.process}" }, mode: 'copy', pattern: "*_metrics.json"
-
+process analyze_shifts {
input:
- tuple val(slice_id), path(mosaic_grid), path(input_transform)
+ path shifts_file
output:
- tuple val(slice_id), path("slice_z${slice_id}_stitch_3d.ome.zarr"), emit: stitched
- path("*_metrics.json"), optional: true, emit: metrics
+ path "shifts_analysis/*"
script:
- def transform_arg = input_transform.name != 'NO_TRANSFORM' ? "--input_transform ${input_transform}" : ""
"""
- linum_stitch_3d_refined.py ${mosaic_grid} "slice_z${slice_id}_stitch_3d.ome.zarr" \
- --overlap_fraction ${params.stitch_overlap_fraction} \
- --blending_method ${params.stitch_blending_method} \
- --refinement_mode blend_shift \
- --max_refinement_px ${params.max_blend_refinement_px} \
- ${transform_arg} \
- --n_levels 0 \
- -f
+ linum_analyze_shifts.py ${shifts_file} shifts_analysis \
+ --resolution ${params.resolution} \
+ --iqr_multiplier ${params.outlier_iqr_multiplier}
"""
stub:
"""
- mkdir -p slice_z${slice_id}_stitch_3d.ome.zarr
+ mkdir -p shifts_analysis
+ touch shifts_analysis/placeholder.txt
"""
}
-process generate_stitch_preview {
- publishDir "${params.output}/previews/stitched_slices", mode: 'copy'
+process generate_report {
+ publishDir "${params.output}", mode: 'copy'
input:
- tuple val(slice_id), path(stitched_slice)
+ tuple path(zarr), path(zip), path(png), path(annotated_png)
+ val subject_name
output:
- path "slice_z${slice_id}_stitched.png"
+ path "${subject_name}_quality_report.${params.report_format ?: 'html'}"
script:
+ def fmt = params.report_format ?: 'html'
+ def verbose_flag = params.report_verbose ? "--verbose" : ""
+ def overview_arg = png ? "--overview_png ${png}" : ""
+ def annotated_arg = annotated_png ? "--annotated_png ${annotated_png}" : ""
"""
- linum_screenshot_omezarr.py ${stitched_slice} "slice_z${slice_id}_stitched.png" \
- --z_slice 0
+ linum_generate_pipeline_report.py ${params.output} ${subject_name}_quality_report.${fmt} \
+ --title "Quality Report: ${subject_name}" \
+ --format ${fmt} ${verbose_flag} ${overview_arg} ${annotated_arg}
"""
stub:
"""
- touch slice_z${slice_id}_stitched.png
+ touch ${subject_name}_quality_report.${params.report_format ?: 'html'}
"""
}
// -----------------------------------------------------------------------------
-// Correction Processes
+// Preprocessing Processes
// -----------------------------------------------------------------------------
-process beam_profile_correction {
- publishDir { "${params.output}/${task.process}" }, mode: 'copy', pattern: "*_metrics.json"
+process resample_mosaic_grid {
+ input:
+ tuple val(slice_id), path(mosaic_grid)
+
+ output:
+ tuple val(slice_id), path("mosaic_grid_z${slice_id}_resampled.ome.zarr")
+
+ script:
+ def gpu_flag = params.use_gpu ? "--use_gpu" : "--no-use_gpu"
+ def gpu_pin_block = Helpers.gpuPinBlock(params, "resample slice=${slice_id}")
+ """
+ ${gpu_pin_block}
+ linum_resample_mosaic_grid.py ${mosaic_grid} "mosaic_grid_z${slice_id}_resampled.ome.zarr" \
+ -r ${params.resolution} ${gpu_flag} --n_levels 0 -v
+ """
+
+ stub:
+ """
+ mkdir -p mosaic_grid_z${slice_id}_resampled.ome.zarr
+ """
+}
+
+process fix_focal_curvature {
+ input:
+ tuple val(slice_id), path(mosaic_grid)
+
+ output:
+ tuple val(slice_id), path("mosaic_grid_z${slice_id}_focal_fix.ome.zarr")
+
+ script:
+ def gpu_flag = params.use_gpu ? "--use_gpu" : "--no-use_gpu"
+ """
+ linum_detect_focal_curvature.py ${mosaic_grid} "mosaic_grid_z${slice_id}_focal_fix.ome.zarr" \\
+ --n_levels 0 ${gpu_flag}
+ """
+
+ stub:
+ """
+ mkdir -p mosaic_grid_z${slice_id}_focal_fix.ome.zarr
+ """
+}
+
+process fix_illumination {
+ cpus params.processes
+
+ input:
+ tuple val(slice_id), path(mosaic_grid)
+
+ output:
+ tuple val(slice_id), path("mosaic_grid_z${slice_id}_illum_fix.ome.zarr")
+
+ script:
+ def gpu_flag = params.use_gpu ? "--use_gpu" : "--no-use_gpu"
+ """
+ linum_fix_illumination_3d.py ${mosaic_grid} "mosaic_grid_z${slice_id}_illum_fix.ome.zarr" \
+ --n_processes ${params.processes} \
+ --percentile_max ${params.clip_percentile_upper} ${gpu_flag} --n_levels 0
+ """
+
+ stub:
+ """
+ mkdir -p mosaic_grid_z${slice_id}_illum_fix.ome.zarr
+ """
+}
+
+// -----------------------------------------------------------------------------
+// Stitching Processes
+// -----------------------------------------------------------------------------
+
+process estimate_global_transform {
+ input:
+ path "pool_input/*"
+ path slice_config
+
+ output:
+ path ("global_affine.npy"), emit: transform
+ path ("global_affine.json"), optional: true, emit: diagnostics
+
+ script:
+ def slice_config_arg = slice_config.name != 'NO_SLICE_CONFIG' ? "--slice_config ${slice_config}" : ""
+ def histogram_arg = params.stitch_global_transform_histogram_match ? "--histogram_match" : ""
+ def empty_arg = params.stitch_global_transform_max_empty_fraction != null
+ ? "--max_empty_fraction ${params.stitch_global_transform_max_empty_fraction}"
+ : ""
+ def n_samples_arg = (params.stitch_global_transform_n_samples as int) > 0
+ ? "--n_samples ${params.stitch_global_transform_n_samples as int}"
+ : ""
+ def include_arg = params.stitch_global_transform_slices?.trim()
+ ? "--include_slice " + params.stitch_global_transform_slices.toString().split('[,\\s]+').join(' ')
+ : ""
+ def gpu_flag = params.use_gpu ? "--use_gpu" : "--no-use_gpu"
+ """
+ linum_estimate_global_transform.py pool_input global_affine.npy \
+ --overlap_fraction ${params.stitch_overlap_fraction} \
+ ${slice_config_arg} \
+ ${include_arg} \
+ ${histogram_arg} \
+ ${empty_arg} \
+ ${n_samples_arg} \
+ --seed ${params.stitch_global_transform_seed} \
+ --diagnostics_json global_affine.json \
+ -f ${gpu_flag}
+ """
+
+ stub:
+ """
+ touch global_affine.npy
+ touch global_affine.json
+ """
+}
+
+process stitch_3d_with_refinement {
+ publishDir { "${params.output}/${task.process}" }, mode: 'copy', pattern: "*_metrics.json"
+
+ input:
+ tuple val(slice_id), path(mosaic_grid), path(input_transform)
+
+ output:
+ tuple val(slice_id), path("slice_z${slice_id}_stitch_3d.ome.zarr"), emit: stitched
+ path ("*_metrics.json"), optional: true, emit: metrics
+
+ script:
+ def transform_arg = input_transform.name != 'NO_TRANSFORM' ? "--input_transform ${input_transform}" : ""
+ """
+ linum_stitch_3d_refined.py ${mosaic_grid} "slice_z${slice_id}_stitch_3d.ome.zarr" \
+ --overlap_fraction ${params.stitch_overlap_fraction} \
+ --blending_method ${params.stitch_blending_method} \
+ --refinement_mode blend_shift \
+ --max_refinement_px ${params.max_blend_refinement_px} \
+ ${transform_arg} \
+ --n_levels 0 \
+ -f
+ """
+
+ stub:
+ """
+ mkdir -p slice_z${slice_id}_stitch_3d.ome.zarr
+ """
+}
+
+process generate_stitch_preview {
+ publishDir "${params.output}/previews/stitched_slices", mode: 'copy'
+
+ input:
+ tuple val(slice_id), path(stitched_slice)
+
+ output:
+ path "slice_z${slice_id}_stitched.png"
+
+ script:
+ """
+ linum_screenshot_omezarr.py ${stitched_slice} "slice_z${slice_id}_stitched.png" \
+ --z_slice 0
+ """
+
+ stub:
+ """
+ touch slice_z${slice_id}_stitched.png
+ """
+}
+
+// -----------------------------------------------------------------------------
+// Correction Processes
+// -----------------------------------------------------------------------------
+
+process beam_profile_correction {
+ publishDir { "${params.output}/${task.process}" }, mode: 'copy', pattern: "*_metrics.json"
input:
tuple val(slice_id), path(slice_3d)
output:
tuple val(slice_id), path("slice_z${slice_id}_axial_corr.ome.zarr"), emit: corrected
- path("*_metrics.json"), optional: true, emit: metrics
+ path ("*_metrics.json"), optional: true, emit: metrics
script:
"""
@@ -312,7 +701,7 @@ process crop_interface {
output:
tuple val(slice_id), path("slice_z${slice_id}_crop_interface.ome.zarr"), emit: cropped
- path("*_metrics.json"), optional: true, emit: metrics
+ path ("*_metrics.json"), optional: true, emit: metrics
script:
"""
@@ -336,7 +725,7 @@ process normalize {
output:
tuple val(slice_id), path("slice_z${slice_id}_normalize.ome.zarr"), emit: normalized
- path("*_metrics.json"), optional: true, emit: metrics
+ path ("*_metrics.json"), optional: true, emit: metrics
script:
def gpu_flag = params.use_gpu ? "--use_gpu" : "--no-use_gpu"
@@ -360,9 +749,9 @@ process detect_rehoming_events {
tuple path(shifts_csv), path(slice_config_in)
output:
- path "shifts_xy_clean.csv", emit: corrected_shifts
- path "slice_config.csv", optional: true, emit: slice_config
- path "diagnostics/*", optional: true, emit: diagnostics
+ path "shifts_xy_clean.csv", emit: corrected_shifts
+ path "slice_config.csv", optional: true, emit: slice_config
+ path "diagnostics/*", optional: true, emit: diagnostics
script:
def diag_arg = params.rehoming_diagnostics ? "--diagnostics diagnostics" : ""
@@ -426,14 +815,17 @@ process bring_to_common_space {
script:
def slice_config_arg = slice_config.name != 'NO_SLICE_CONFIG' ? "--slice_config ${slice_config}" : ""
- def excluded_args = params.common_space_excluded_slice_mode ?
- "--excluded_slice_mode ${params.common_space_excluded_slice_mode} --excluded_slice_window ${params.common_space_excluded_slice_window}" : ""
+ def excluded_args = params.common_space_excluded_slice_mode
+ ? "--excluded_slice_mode ${params.common_space_excluded_slice_mode} --excluded_slice_window ${params.common_space_excluded_slice_window}"
+ : ""
def refine_arg = params.common_space_refine_unreliable ? "--refine_unreliable" : ""
- def discrepancy_arg = (params.common_space_refine_unreliable && params.common_space_refine_max_discrepancy_px > 0) ?
- "--refine_max_discrepancy_px ${params.common_space_refine_max_discrepancy_px}" : ""
- def min_corr_arg = (params.common_space_refine_unreliable && params.common_space_refine_min_correlation > 0) ?
- "--refine_min_correlation ${params.common_space_refine_min_correlation}" : ""
+ def discrepancy_arg = (params.common_space_refine_unreliable && params.common_space_refine_max_discrepancy_px > 0)
+ ? "--refine_max_discrepancy_px ${params.common_space_refine_max_discrepancy_px}"
+ : ""
+ def min_corr_arg = (params.common_space_refine_unreliable && params.common_space_refine_min_correlation > 0)
+ ? "--refine_min_correlation ${params.common_space_refine_min_correlation}"
+ : ""
"""
linum_align_mosaics_3d_from_shifts.py inputs shifts_xy.csv common_space \
@@ -639,14 +1031,15 @@ process make_manual_align_package {
tuple path("slices/*"), path("transforms/*")
output:
- path("manual_align_package"), emit: pkg
+ path ("manual_align_package"), emit: pkg
script:
// When interpolation is enabled, interpolated slices live in a separate
// publish dir (interpolate_missing_slice/) rather than bring_to_common_space/.
// Pass that directory so the plugin's SSH reader can locate them.
- def interp_dir_opt = params.interpolate_missing_slices ?
- "--interpolated_slices_remote_dir ${params.output}/interpolate_missing_slice" : ""
+ def interp_dir_opt = params.interpolate_missing_slices
+ ? "--interpolated_slices_remote_dir ${params.output}/interpolate_missing_slice"
+ : ""
"""
linum_export_manual_align.py slices transforms manual_align_package \
--level ${params.manual_align_level} \
@@ -666,31 +1059,20 @@ process make_manual_align_package {
// publishDir mode is conditional: 'symlink' when a downstream step will produce
// the final output (preserves work-dir files for -resume); 'move' when this is last.
process stack {
- publishDir { "${params.output}/${task.process}" },
- mode: (params.correct_bias_field || params.align_to_ras_enabled) ? 'symlink' : 'move',
- saveAs: { fn -> fn.endsWith('.ome.zarr') ? null : fn }
+ publishDir { "${params.output}/${task.process}" }, mode: (params.correct_bias_field || params.align_to_ras_enabled) ? 'symlink' : 'move', saveAs: { fn -> fn.endsWith('.ome.zarr') ? null : fn }
input:
tuple path("slices/*"), path(shifts_file), path("transforms/*"), path(slice_config), val(subject_name), val(slice_ids_str)
output:
tuple path("${subject_name}.ome.zarr"), path("${subject_name}.ome.zarr.zip"), path("${subject_name}.png"), path("${subject_name}_annotated.png"), emit: volume
- path("*_metrics.json"), optional: true, emit: metrics
- path("z_matches.csv"), optional: true, emit: z_matches
- path("stacking_decisions.csv"), optional: true, emit: stacking_decisions
+ path ("*_metrics.json"), optional: true, emit: metrics
+ path ("z_matches.csv"), optional: true, emit: z_matches
+ path ("stacking_decisions.csv"), optional: true, emit: stacking_decisions
script:
def gpu_flag = params.use_gpu ? " --use_gpu" : " --no-use_gpu"
- def options = Helpers.stackBlendingArgs(params) +
- Helpers.stackZMatchingArgs(params) +
- Helpers.stackPairwiseTransformArgs(params) +
- Helpers.stackSliceConfigArg(slice_config) +
- Helpers.stackManualOverrideArg(params) +
- Helpers.stackCumulativeArgs(params) +
- Helpers.stackSmoothingArgs(params) +
- " --no_xy_shift" + // slices are already in common space
- gpu_flag +
- Helpers.pyramidArgs(params)
+ def options = Helpers.stackBlendingArgs(params) + Helpers.stackZMatchingArgs(params) + Helpers.stackPairwiseTransformArgs(params) + Helpers.stackSliceConfigArg(slice_config) + Helpers.stackManualOverrideArg(params) + Helpers.stackCumulativeArgs(params) + Helpers.stackSmoothingArgs(params) + " --no_xy_shift" + gpu_flag + Helpers.pyramidArgs(params)
def annotated_args = Helpers.annotatedScreenshotArgs(params, slice_ids_str)
"""
@@ -714,9 +1096,7 @@ process stack {
process correct_bias_field {
cpus params.processes
- publishDir { "${params.output}/${task.process}" },
- mode: params.align_to_ras_enabled ? 'symlink' : 'move',
- saveAs: { fn -> fn.endsWith('.ome.zarr') ? null : fn }
+ publishDir { "${params.output}/${task.process}" }, mode: params.align_to_ras_enabled ? 'symlink' : 'move', saveAs: { fn -> fn.endsWith('.ome.zarr') ? null : fn }
input:
tuple path(stacked_zarr), val(subject_name), val(n_slices), val(slice_ids_str)
@@ -799,370 +1179,3 @@ process align_to_ras {
touch ${subject_name}_ras.ome.zarr.zip
"""
}
-
-// =============================================================================
-// MAIN WORKFLOW
-// =============================================================================
-
-workflow {
- README()
-
- def inputDir = Helpers.normalizePath(params.input)
- def subject_name = Helpers.resolveSubjectName(inputDir, params.subject_name)
- log.info "Subject: ${subject_name}"
- log.info "GPU: ${params.use_gpu ? 'ENABLED' : 'DISABLED'}"
-
- def debugSlices = Helpers.parseDebugSlices(params.debug_slices)
- if (debugSlices) {
- log.info "DEBUG MODE: Processing only slices ${debugSlices.sort().join(', ')}"
- }
-
- // Shifts file
- def shifts_xy_path = params.shifts_xy ?: "${inputDir}/shifts_xy.csv"
- log.info "Shifts file: ${shifts_xy_path}"
-
- if (!file(shifts_xy_path).exists()) {
- error """
- Shifts file not found: ${shifts_xy_path}
-
- Please ensure shifts_xy.csv exists in your input directory,
- or specify the path with --shifts_xy /path/to/shifts_xy.csv
- """
- }
- // Value channel — fans out to many consumers; see "Authoring Notes" in
- // docs/NEXTFLOW_WORKFLOWS.md.
- shifts_xy = channel.value(file(shifts_xy_path))
-
- // Slice config (optional)
- def slice_config_path = params.slice_config ?: Helpers.joinPath(inputDir, "slice_config.csv")
- def slicesToUse = null
- if (file(slice_config_path).exists()) {
- log.info "Slice config: ${slice_config_path}"
- def parsed = Helpers.parseSliceConfig(slice_config_path)
- slicesToUse = parsed.use
- def total = slicesToUse.size() + parsed.excluded.size()
- log.info "Slice config: ${total} entries (${slicesToUse.size()} included, ${parsed.excluded.size()} excluded)"
- } else if (params.slice_config) {
- error("Slice config file not found: ${slice_config_path}")
- }
-
- // Discover input mosaic grids
- log.info "Looking for mosaic grids in: ${inputDir}"
-
- def inputDirFile = file(inputDir)
- def mosaicFiles = inputDirFile.listFiles()
- .findAll { f -> f.isDirectory() && f.name.startsWith('mosaic_grid') && f.name.endsWith('.ome.zarr') && f.name =~ /z\d+/ }
- .sort { f -> f.name }
-
- if (mosaicFiles.isEmpty()) {
- error("No mosaic grids found in ${inputDir}. Expected: mosaic_grid*_z00.ome.zarr")
- }
-
- def selectedIds = mosaicFiles.collect { f -> Helpers.extractSliceId(f) }.findAll { sid ->
- if (debugSlices != null) return debugSlices.contains(sid)
- if (slicesToUse != null) return slicesToUse.contains(sid)
- return true
- }
- def skippedCount = mosaicFiles.size() - selectedIds.size()
- if (skippedCount > 0) {
- def reason = debugSlices != null ? "debug_slices filter" : "slice_config"
- log.info "Found ${mosaicFiles.size()} mosaic grids; ${selectedIds.size()} selected, ${skippedCount} skipped (${reason})"
- } else {
- log.info "Found ${mosaicFiles.size()} mosaic grids; all selected"
- }
-
- inputSlices = channel
- .fromList(mosaicFiles)
- .map { f -> Helpers.toSliceTuple(f) }
- .filter { slice_id, _files ->
- if (debugSlices != null) {
- def included = debugSlices.contains(slice_id)
- if (!included) log.debug "Skipping slice ${slice_id} (not in debug_slices)"
- return included
- }
- if (slicesToUse != null) return slicesToUse.contains(slice_id)
- return true
- }
-
- def has_slice_config = file(slice_config_path).exists() || params.auto_assess_quality
- // Value channel — consumed by auto_assess, common_space, finalise, stack.
- slice_config_channel = channel.value(
- file(slice_config_path).exists() ? file(slice_config_path) : file('NO_SLICE_CONFIG')
- )
-
- if (params.analyze_shifts) {
- analyze_shifts(shifts_xy)
- }
-
- // Stage 1: Preprocessing
- resampled = params.resolution > 0 ? resample_mosaic_grid(inputSlices) : inputSlices
- focal_fixed = params.fix_curvature_enabled ? fix_focal_curvature(resampled) : resampled
- illum_fixed = params.fix_illum_enabled ? fix_illumination(focal_fixed) : focal_fixed
-
- // Stage 2: XY Stitching (image-registration-based blend refinement)
- if (params.stitch_global_transform) {
- pooled_mosaics = illum_fixed.map { _id, p -> p }.collect()
- estimate_global_transform(pooled_mosaics, slice_config_channel)
- stitch_inputs = illum_fixed.combine(estimate_global_transform.out.transform)
- } else {
- // Value channel so the placeholder can fan out to every per-slice tuple.
- no_transform = channel.value(file('NO_TRANSFORM'))
- stitch_inputs = illum_fixed.combine(no_transform)
- }
- stitch_3d_with_refinement(stitch_inputs)
- stitched_slices = stitch_3d_with_refinement.out.stitched
-
- if (params.stitch_preview) {
- generate_stitch_preview(stitched_slices)
- }
-
- // Stage 3: Corrections
- beam_profile_correction(stitched_slices)
- crop_interface(beam_profile_correction.out.corrected)
- normalize(crop_interface.out.cropped)
-
- // Stage 3.5: Auto slice quality assessment (optional). Generates a
- // slice_config.csv that marks degraded slices; an existing static
- // slice_config.csv is merged so manually-excluded slices stay excluded.
- // current_slice_config = the latest slice_config as it flows through the
- // pipeline; rebound by auto_assess / detect_rehoming when each runs.
- current_slice_config = slice_config_channel
- if (params.auto_assess_quality) {
- auto_assess_inputs = normalize.out.normalized
- .map { _id, norm_path -> norm_path }
- .collect()
- auto_assess_quality(auto_assess_inputs, slice_config_channel)
- current_slice_config = auto_assess_quality.out.slice_config
- }
-
- // Stage 4: Common Space Alignment.
- // detect_rehoming optionally corrects encoder-glitch spikes in the
- // shifts file and (when a real slice_config exists) stamps
- // rehomed/rehoming_reliable flags back into it.
- if (params.detect_rehoming) {
- detect_rehoming_input = shifts_xy.combine(current_slice_config)
- detect_rehoming_events(detect_rehoming_input)
- aligned_shifts = detect_rehoming_events.out.corrected_shifts
- if (has_slice_config) {
- current_slice_config = detect_rehoming_events.out.slice_config
- }
- } else {
- aligned_shifts = shifts_xy
- }
-
- common_space_input = normalize.out.normalized
- .toSortedList { a, b -> a[0] <=> b[0] }
- .flatten()
- .collate(2)
- .map { _meta, filename -> filename }
- .collect()
- .merge(aligned_shifts) { a, b -> tuple(a, b) }
- .merge(current_slice_config) { a, b -> tuple(a[0], a[1], b) }
-
- bring_to_common_space(common_space_input)
-
- slices_common_space = bring_to_common_space.out
- .flatten()
- .toSortedList { a, b -> a.getName() <=> b.getName() }
-
- if (params.common_space_preview) {
- preview_input = bring_to_common_space.out
- .flatten()
- .map { f -> Helpers.toSliceTuple(f) }
- generate_common_space_preview(preview_input)
- }
-
- // Stage 5: Missing Slice Interpolation (optional).
- // Single-slice gaps (use=false slices already filtered upstream) are
- // interpolated with zmorph; per-slice diagnostics are merged into
- // slice_config_final.csv. See docs/SLICE_INTERPOLATION_FEATURE.md.
- if (params.interpolate_missing_slices) {
- gaps_channel = slices_common_space
- .map { sliceList -> [Helpers.detectSingleGaps(sliceList), sliceList] }
- .flatMap { gapsAndSlices ->
- def gaps = gapsAndSlices[0]
- def sliceList = gapsAndSlices[1]
- if (gaps.isEmpty()) return []
-
- gaps.collect { gap ->
- def (missingId, beforeId, afterId) = gap
- def sliceBefore = sliceList.find { f -> f.getName().contains("slice_z${beforeId}") }
- def sliceAfter = sliceList.find { f -> f.getName().contains("slice_z${afterId}") }
- (sliceBefore && sliceAfter) ? tuple(missingId, sliceBefore, sliceAfter) : null
- }.findAll { item -> item != null }
- }
-
- interpolate_missing_slice(gaps_channel)
-
- // Publish slice_config_final.csv as an artifact for the report.
- // Intentionally NOT piped back into current_slice_config: when no
- // gaps exist, interpolate_missing_slice does not run and finalise's
- // output channel is empty, which would in turn empty out
- // current_slice_config and silently skip stack. Stack only reads
- // use/auto_excluded — neither column is modified here — so reading
- // the upstream config is equivalent.
- if (has_slice_config) {
- finalise_interpolation(
- current_slice_config,
- interpolate_missing_slice.out.manifest.collect(),
- )
- }
-
- all_slices = slices_common_space
- .mix(interpolate_missing_slice.out.zarr.collect())
- .flatten()
- .toSortedList { a, b -> a.getName() <=> b.getName() }
- } else {
- all_slices = slices_common_space
- }
-
- // Stage 6: Pairwise Registration
- log.info "Registering slices pairwise"
-
- fixed_slices = all_slices
- .map { list -> list.size() > 1 ? list.subList(0, list.size() - 1) : [] }
- .flatten()
- moving_slices = all_slices
- .map { list -> list.size() > 1 ? list.subList(1, list.size()) : [] }
- .flatten()
- pairs = fixed_slices.merge(moving_slices)
-
- register_pairwise(pairs)
-
- slices_collected = all_slices.flatten().collect()
- transforms_collected = register_pairwise.out.collect()
-
- // Stage 6.5: Export manual-alignment package (optional).
- if (params.export_manual_align) {
- export_input = slices_collected
- .combine(transforms_collected)
- .map { items -> Helpers.partitionSlicesAndTransforms(items) }
- make_manual_align_package(export_input)
- }
-
- // Stage 6.75: Refine manual transforms (optional). Re-runs pairwise
- // registration initialised from each manual transform; non-manual pairs
- // are copied unchanged. Refined outputs replace automated transforms.
- if (params.refine_manual_transforms && params.manual_transforms_dir) {
- log.info "Refining manual transforms from: ${params.manual_transforms_dir}"
- // Re-derive pairs from all_slices (value channel, safe to reuse)
- refine_fixed = all_slices
- .map { list -> list.size() > 1 ? list.subList(0, list.size() - 1) : [] }
- .flatten()
- refine_moving = all_slices
- .map { list -> list.size() > 1 ? list.subList(1, list.size()) : [] }
- .flatten()
- // Key pairs by moving zarr basename (= transform dir name)
- refine_pairs_keyed = refine_fixed
- .merge(refine_moving)
- .map { fixed, moving -> tuple(moving.getName().replace('.ome.zarr', ''), fixed, moving) }
- // Key auto transform dirs by dir name
- auto_transforms_keyed = register_pairwise.out
- .flatten()
- .filter { f -> !f.getName().endsWith('.ome.zarr') }
- .map { dir -> tuple(dir.getName(), dir) }
- // Join pairs with their corresponding auto transform dir
- refine_input = refine_pairs_keyed
- .join(auto_transforms_keyed)
- .map { _id, fixed, moving, auto_tfm -> tuple(fixed, moving, auto_tfm) }
- refine_manual_transforms(refine_input)
- transforms_for_stack = refine_manual_transforms.out.collect()
- } else {
- transforms_for_stack = transforms_collected
- }
-
- // Stage 7: Stacking
- log.info "Stacking slices with registration refinements"
-
- // Auto-exclude: detect clusters of consecutive low-quality registrations.
- // Stamps auto_excluded/auto_exclude_reason into slice_config so stack
- // sees them via --slice_config. Requires a real slice_config.
- stack_slice_config = current_slice_config
- if (params.auto_exclude_enabled && has_slice_config) {
- auto_exclude_slices(transforms_for_stack, current_slice_config)
- stack_slice_config = auto_exclude_slices.out.slice_config
- }
-
- // Build stack_input with `merge` (preserves list-vs-file structure of each
- // input). Earlier versions used `combine`, which flattens lists into a
- // single tuple and forced fragile filename-based dispatch in `.map`.
- stack_input = slices_collected
- .merge(shifts_xy) { s, x -> tuple(s, x) }
- .merge(transforms_for_stack) { acc, t -> tuple(acc[0], acc[1], t) }
- .merge(stack_slice_config) { acc, sc -> tuple(acc[0], acc[1], acc[2], sc) }
- .map { slices, shifts, transforms, sc ->
- tuple(slices, shifts, transforms, sc, subject_name, Helpers.extractSliceIdsString(slices))
- }
-
- stack(stack_input)
- stack_output = stack.out.volume
- stack_metadata = stack_input.map { _slices, _shifts, _transforms, _sc, name, ids_str ->
- tuple(name, ids_str.split(',').size(), ids_str)
- }
-
- // Stage 8: Bias Field Correction (optional)
- if (params.correct_bias_field) {
- log.info "Running N4 bias field correction (mode=${params.bias_mode})"
- znorm_input = stack_output
- .combine(stack_metadata)
- .map { zarr, _zip, _png, _annotated, name, n, ids_str -> tuple(zarr, name, n, ids_str) }
- correct_bias_field(znorm_input)
- final_stack_output = correct_bias_field.out
- } else {
- final_stack_output = stack_output
- }
-
- // Stage 9: Report Generation (optional)
- if (params.generate_report) {
- generate_report(final_stack_output, subject_name)
- }
-
- // Stage 10: Atlas Registration (optional)
- if (params.align_to_ras_enabled) {
- log.info "Registering to Allen Mouse Brain Atlas (RAS alignment)"
- align_to_ras(final_stack_output, subject_name)
- }
-
- // Stage 11: Diagnostics (optional). Toggle individually or via diagnostic_mode.
- if (params.diagnostic_mode) {
- log.info "DIAGNOSTIC MODE enabled (acq rotation, rotation drift, motor-only stitch/stack)"
- }
-
- if (Helpers.diagEnabled(params, 'analyze_acquisition_rotation')) {
- analyze_acquisition_rotation(shifts_xy, register_pairwise.out.collect())
- }
-
- if (Helpers.diagEnabled(params, 'analyze_rotation_drift')) {
- analyze_rotation_drift(register_pairwise.out.collect())
- }
-
- if (Helpers.diagEnabled(params, 'motor_only_stack')) {
- motor_only_stack_input = normalize.out.normalized
- .map { _id, slice_file -> slice_file }
- .collect()
- stack_motor_only(motor_only_stack_input, shifts_xy)
- }
-
- // motor_only_stitch is also a prerequisite for compare_stitching, so run it
- // whenever either is requested. A second `stitch_motor_only(illum_fixed)`
- // call would emit the same channel twice, which Nextflow forbids.
- def runMotorStitch = Helpers.diagEnabled(params, 'motor_only_stitch')
- def runComparison = params.compare_stitching || params.diagnostic_mode
- if (runMotorStitch || runComparison) {
- stitch_motor_only(illum_fixed)
- }
-
- if (runComparison) {
- log.info "Running stitching comparison (motor-only vs refined)..."
-
- stitch_refined(illum_fixed)
-
- motor_stitch_with_id = stitch_motor_only.out.map { f -> Helpers.toSliceTuple(f) }
- refined_stitch_with_id = stitch_refined.out[0].map { f -> Helpers.toSliceTuple(f) }
-
- comparison_input = motor_stitch_with_id
- .combine(refined_stitch_with_id, by: 0)
-
- compare_stitching(comparison_input)
- }
-}