diff --git a/pkg/controller/common/constants.go b/pkg/controller/common/constants.go
index 31ba8b1040..1f890d0eb8 100644
--- a/pkg/controller/common/constants.go
+++ b/pkg/controller/common/constants.go
@@ -160,6 +160,11 @@ const (
 	// Note: Update units in status_test.go when the following are bumped
 	RHCOSVersionBootImageSkewLimit = "9.2"
 	OCPVersionBootImageSkewLimit   = "4.13.0"
+
+	// MaxMachineConfigSize is the maximum size for a MachineConfig object in bytes.
+	// This matches etcd's default request size limit of 1.5MB (1572864 bytes).
+	// Reference: https://issues.redhat.com/browse/OCPBUGS-62619
+	MaxMachineConfigSize = 1572864
 )
 
 // Commonly-used MCO ConfigMap names
diff --git a/pkg/controller/common/helpers.go b/pkg/controller/common/helpers.go
index 54bb1a4305..8bd49484f5 100644
--- a/pkg/controller/common/helpers.go
+++ b/pkg/controller/common/helpers.go
@@ -468,6 +468,43 @@ func ValidateMachineConfig(cfg mcfgv1.MachineConfigSpec) error {
 	return nil
 }
 
+// ValidateMachineConfigSize checks if the MachineConfig size exceeds etcd limits.
+// etcd has a default request size limit of 1.5MB. This function validates that the
+// rendered MachineConfig does not exceed this limit to prevent "etcdserver: request
+// is too large" errors.
+func ValidateMachineConfigSize(mc *mcfgv1.MachineConfig) error {
+	// Marshal the MachineConfig to JSON to get its actual size as it will be sent to etcd
+	data, err := json.Marshal(mc)
+	if err != nil {
+		return fmt.Errorf("failed to marshal MachineConfig: %w", err)
+	}
+
+	size := len(data)
+
+	// Check if size exceeds the limit
+	if size > MaxMachineConfigSize {
+		return fmt.Errorf("rendered MachineConfig %s is too large (%d bytes, max %d bytes). "+
+			"This will exceed etcd's size limit. Consider reducing the number or size of MachineConfigs, "+
+			"particularly large registry mirror configurations (ImageDigestMirrorSet/ImageContentSourcePolicy)",
+			mc.Name, size, MaxMachineConfigSize)
+	}
+
+	// Log size information at debug level
+	percentUsed := float64(size) / float64(MaxMachineConfigSize) * 100
+	klog.V(4).Infof("MachineConfig %s size: %d bytes (%.2f%% of %d byte limit)",
+		mc.Name, size, percentUsed, MaxMachineConfigSize)
+
+	// Warn if approaching the limit (> 80%)
+	warningThreshold := (MaxMachineConfigSize * 4) / 5
+	if size > warningThreshold {
+		klog.Warningf("MachineConfig %s is approaching size limit: %d bytes (%.2f%% of %d byte limit). "+
+			"Consider reducing MachineConfig size to avoid hitting the limit.",
+			mc.Name, size, percentUsed, MaxMachineConfigSize)
+	}
+
+	return nil
+}
+
 // Validates that a given MachineConfig's extensions are supported.
 func ValidateMachineConfigExtensions(cfg mcfgv1.MachineConfigSpec) error {
 	return validateExtensions(cfg.Extensions)
diff --git a/pkg/controller/render/render_controller.go b/pkg/controller/render/render_controller.go
index 1d78e369ea..440ccabaa2 100644
--- a/pkg/controller/render/render_controller.go
+++ b/pkg/controller/render/render_controller.go
@@ -602,6 +602,11 @@ func (ctrl *Controller) syncGeneratedMachineConfig(pool *mcfgv1.MachineConfigPoo
 		return fmt.Errorf("could not generate rendered MachineConfig: %w", err)
 	}
 
+	// Validate that the generated MachineConfig does not exceed etcd size limits
+	if err := ctrlcommon.ValidateMachineConfigSize(generated); err != nil {
+		return fmt.Errorf("size validation failed: %w", err)
+	}
+
 	// Collect metric when OSImageURL was overridden
 	var isOSImageURLOverridden bool
 	if generated.Spec.OSImageURL != ctrlcommon.GetBaseImageContainer(&cc.Spec, osImageStreamSet) {