diff --git a/eventstore_test.go b/eventstore_test.go
index b93901c..9351fd2 100644
--- a/eventstore_test.go
+++ b/eventstore_test.go
@@ -140,6 +140,39 @@ func TestEventStoreNoRegistry(t *testing.T) {
 	is.Equal(events[0].Data, []byte("hello"))
 }
 
+func TestWithAPIPrefix(t *testing.T) {
+	is := testutil.NewIs(t)
+
+	srv := testutil.NewNatsServerWithDomain(t, "test")
+	defer testutil.ShutdownNatsServer(srv)
+
+	nc, err := nats.Connect(srv.ClientURL())
+	is.NoErr(err)
+
+	m, err := New(nc, WithAPIPrefix("$JS.test.API"))
+	is.NoErr(err)
+
+	ctx := context.Background()
+	es, err := m.CreateEventStore(ctx, EventStoreConfig{
+		Name: "store",
+	})
+	is.NoErr(err)
+
+	seq, err := es.Append(ctx, []*Event{{
+		Entity: "order.1",
+		Type:   "foo",
+		Data:   []byte("hello"),
+	}})
+	is.NoErr(err)
+	is.Equal(seq, uint64(1))
+
+	var events eventSlice
+	_, err = es.Evolve(ctx, &events)
+	is.NoErr(err)
+	is.Equal(events[0].Type, "foo")
+	is.Equal(events[0].Data, []byte("hello"))
+}
+
 func TestEventStoreWithRegistry(t *testing.T) {
 	is := testutil.NewIs(t)
 
diff --git a/manager.go b/manager.go
index 3cd6a52..c0f5000 100644
--- a/manager.go
+++ b/manager.go
@@ -60,6 +60,14 @@ func WithLogger(logger *slog.Logger) ManagerOption {
 	})
 }
 
+// WithAPIPrefix sets a custom JetStream API prefix on the NATS connection.
+func WithAPIPrefix(apiPrefix string) ManagerOption {
+	return managerOption(func(o *Manager) error {
+		o.apiPrefix = apiPrefix
+		return nil
+	})
+}
+
 func eventSubject(name string, event *Event) string {
 	return fmt.Sprintf(eventStoreSubjectTmpl+"%s.%s", name, event.Entity, event.Type)
 }
@@ -83,6 +91,7 @@ type Manager struct {
 	logger *slog.Logger
 	nc     *nats.Conn
 	js     jetstream.JetStream
+	apiPrefix string
 	types  *types.Registry
 	id     id.ID
 	clock  clock.Clock
@@ -188,15 +197,9 @@ func (m *Manager) DeleteEventStore(ctx context.Context, name string) error {
 
 // New initializes a new Manager instance with a NATS connection.
 func New(nc *nats.Conn, opts ...ManagerOption) (*Manager, error) {
-	js, err := jetstream.New(nc)
-	if err != nil {
-		return nil, err
-	}
-
 	m := &Manager{
 		nc:     nc,
 		logger: slog.Default(),
-		js:     js,
 		id:     id.NUID,
 		clock:  clock.Time,
 	}
@@ -207,5 +210,17 @@ func New(nc *nats.Conn, opts ...ManagerOption) (*Manager, error) {
 		}
 	}
 
+	var js jetstream.JetStream
+	var err error
+	if m.apiPrefix != "" {
+		js, err = jetstream.NewWithAPIPrefix(nc, m.apiPrefix)
+	} else {
+		js, err = jetstream.New(nc)
+	}
+	if err != nil {
+		return nil, err
+	}
+	m.js = js
+
 	return m, nil
 }
diff --git a/testutil/nats.go b/testutil/nats.go
index afcb36e..5175846 100644
--- a/testutil/nats.go
+++ b/testutil/nats.go
@@ -19,6 +19,15 @@ func NewNatsServer(tb testing.TB) *server.Server {
 	return NewNatsServerWithDir(tb.TempDir())
 }
 
+func NewNatsServerWithDomain(tb testing.TB, domain string) *server.Server {
+	opts := natsserver.DefaultTestOptions
+	opts.Port = -1
+	opts.JetStream = true
+	opts.JetStreamDomain = domain
+	opts.StoreDir = tb.TempDir()
+	return natsserver.RunServer(&opts)
+}
+
 func ShutdownNatsServer(s *server.Server) {
 	s.Shutdown()
 	s.WaitForShutdown()