diff --git a/CHANGELOG.md b/CHANGELOG.md
index 061915c..1c4b369 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,11 @@
 
 All notable changes to the "python-envy" extension will be documented in this file.
 
+## [0.1.12]
+- Add PEP 723 inline script metadata support. When a Python file contains `# /// script` metadata,
+  `uv python find --script` is used to resolve and activate the correct Python interpreter.
+  Requires [uv](https://docs.astral.sh/uv/) to be installed. Can be toggled with `pythonEnvy.enablePep723`.
+
 ## [0.1.11]
 - Fix issue [#8](https://github.com/teticio/python-envy/issues/8) introduce option to disable notification
   when the interpreter gets activated/switched.
diff --git a/README.md b/README.md
index ae11535..0a1454e 100644
--- a/README.md
+++ b/README.md
@@ -22,6 +22,7 @@ This extension has the following settings:
 
 * `pythonEnvy.venv`: Location of the virtual environments. Set to `.venv` by default.
 * `pythonEnvy.showNotifications`: Show information messages when Python interpreter is automatically switched. Set to `true` by default.
+* `pythonEnvy.enablePep723`: Detect [PEP 723](https://peps.python.org/pep-0723/) inline script metadata and use `uv python find --script` to activate the appropriate Python interpreter. Requires [uv](https://docs.astral.sh/uv/) to be installed. Set to `true` by default.
 
 ## Known Issues
 
diff --git a/extension.js b/extension.js
index 856f907..5fc7c1a 100644
--- a/extension.js
+++ b/extension.js
@@ -2,6 +2,40 @@ const { PythonExtension } = require("@vscode/python-extension");
 const vscode = require("vscode");
 const fs = require("fs");
 const path = require("path");
+const { execFile } = require("child_process");
+const { promisify } = require("util");
+
+const execFileAsync = promisify(execFile);
+
+/**
+ * Check if a file contains PEP 723 inline script metadata.
+ * PEP 723 format:
+ *   # /// script
+ *   # ...TOML metadata...
+ *   # ///
+ */
+function hasPep723Metadata(filePath) {
+    try {
+        const content = fs.readFileSync(filePath, "utf-8");
+        return /^# \/\/\/ script\s*$/m.test(content);
+    } catch (_err) {
+        return false;
+    }
+}
+
+/**
+ * Run `uv python find --script <filePath>` to resolve the Python interpreter
+ * for a PEP 723 script.
+ * @returns {Promise<string|null>} The Python interpreter path, or null on failure.
+ */
+async function getUvScriptPythonPath(filePath) {
+    try {
+        const { stdout } = await execFileAsync("uv", ["python", "find", "--script", filePath]);
+        return stdout.trim() || null;
+    } catch (_err) {
+        return null;
+    }
+}
 
 /**
  * @param {vscode.ExtensionContext} context
@@ -24,7 +58,8 @@ async function activate(context) {
 }
 
 async function setupPythonEnvironment(editor, pythonApi) {
-    let currentDir = path.dirname(editor.document.uri.fsPath);
+    const filePath = editor.document.uri.fsPath;
+    let currentDir = path.dirname(filePath);
     const root = path.parse(currentDir).root;
     const currentWorkspaceFolder = vscode.workspace.getWorkspaceFolder(vscode.Uri.file(editor.document.uri.path));
     const currentWorkspaceFolderPath = currentWorkspaceFolder ? currentWorkspaceFolder.uri.path : null;
@@ -33,6 +68,53 @@ async function setupPythonEnvironment(editor, pythonApi) {
     const config = vscode.workspace.getConfiguration('pythonEnvy');
     const venvName = config.get('venvName');
     const showNotifications = config.get('showNotifications', true); // Default to true for backward compatibility
+    const enablePep723 = config.get('enablePep723', true);
+
+    // Check for PEP 723 inline script metadata (requires uv)
+    if (enablePep723 && filePath.endsWith(".py") && hasPep723Metadata(filePath)) {
+        const pythonPath = await getUvScriptPythonPath(filePath);
+        if (pythonPath) {
+            if (!fs.existsSync(pythonPath)) {
+                if (showNotifications) {
+                    vscode.window.showInformationMessage(
+                        "Python Envy: PEP 723 script environment has not been created yet."
+                    );
+                }
+                return;
+            }
+
+            const currentPythonPath =
+                pythonApi.environments.getActiveEnvironmentPath(
+                    currentWorkspaceFolder ? currentWorkspaceFolder.uri : undefined
+                );
+
+            if (currentPythonPath.path !== pythonPath) {
+                try {
+                    await pythonApi.environments.updateActiveEnvironmentPath(
+                        pythonPath,
+                        currentWorkspaceFolder ? currentWorkspaceFolder.uri : undefined
+                    );
+
+                    if (showNotifications) {
+                        const displayPath = currentWorkspaceFolderPath
+                            ? path.relative(currentWorkspaceFolderPath, pythonPath)
+                            : pythonPath;
+                        const folderName = currentWorkspaceFolder
+                            ? " for " + currentWorkspaceFolder.name
+                            : "";
+                        vscode.window.showInformationMessage(
+                            `Python Envy: PEP 723 script interpreter set to ${displayPath}${folderName}`
+                        );
+                    }
+                } catch (error) {
+                    vscode.window.showErrorMessage(
+                        `Python Envy: error setting Python interpreter for PEP 723 script: ${error.message}`
+                    );
+                }
+            }
+            return;
+        }
+    }
 
     while (currentDir !== root) {
         const venvPath = path.join(currentDir, venvName);
@@ -83,4 +165,6 @@ function deactivate() { }
 module.exports = {
     activate,
     deactivate,
+    hasPep723Metadata,
+    getUvScriptPythonPath,
 };
diff --git a/package.json b/package.json
index 7b26332..453e940 100644
--- a/package.json
+++ b/package.json
@@ -8,7 +8,7 @@
     "type": "git",
     "url": "https://github.com/teticio/python-envy.git"
   },
-  "version": "0.1.11",
+  "version": "0.1.12",
   "engines": {
     "vscode": "^1.85.0"
   },
@@ -51,6 +51,11 @@
           "type": "boolean",
           "default": true,
           "description": "Show information messages when Python interpreter is automatically switched"
+        },
+        "pythonEnvy.enablePep723": {
+          "type": "boolean",
+          "default": true,
+          "description": "Detect PEP 723 inline script metadata and use `uv python find --script` to activate the appropriate Python interpreter. Requires uv to be installed."
         }
       }
     }