BB-PRED: Machine learning based drug permeablity prediction across Blood-Brain barrier in CNS.

What is blood brain barrier?

The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that prevents solutes in the circulating blood from non-selectively crossing into the extracellular fluid of the central nervous system where neurons reside.

What obstacles faced during drug discovery?

Drug design and discovery is a very expensive process, with numerous new compounds being developed at a rapid rate. Only around 2% of known drugs can pass through the BBB, this presents a problem in the Central Nervous System (CNS) drug development.

AIM OF THE PROJECT:

This project aims to develop a solution that can predict, with confidence, the probability of a drug passing through the BBB in the hope that this can speed up the process of developing a CNS drug.

Workflow of the Project

TEST RESULT OF BEST MODEL

This project is still active more work in being going this project, addtional propertie of drug and protein on the membrane is also considered in future update.

Refrences:

• Martins e.tal
• Gupta etal
• William A Banks[doi:10.1186/1471-2377-9-S1-S3]