This project focuses on the structural analysis of the BRCA1 protein using the AlphaFold Protein Structure Database. The study includes protein structure visualization, pLDDT confidence analysis, Predicted Aligned Error (PAE) interpretation, and domain organization analysis.
| Parameter | Details |
|---|---|
| Protein | BRCA1 |
| Organism | Homo sapiens |
| UniProt ID | P38398 |
- AlphaFold Protein Structure Database
- UniProt
- Protein Data Bank (PDB)
- Retrieve BRCA1 structure from AlphaFold
- Visualize the predicted 3D structure
- Analyze pLDDT confidence scores
- Examine PAE plots
- Study domain organization and flexible regions
- BRCA1 contains both structured and disordered regions
- High-confidence domains were identified using pLDDT scores
- PAE analysis revealed flexible linker regions
- Domain analysis showed modular structural organization
- Project Report (PDF)
- AlphaFold screenshots
- Structural analysis images
Aastha Mani
B.Tech Biotechnology
Graphic Era University