Author: Collin Blaine George
Affiliation: Clinical Research & Medicine Practice
Governing Standard: CM-STYLE-01 v2.0 · PRISMA-ScR/JBI · ICH-GCP E6(R3) · GRADE · AMA Manual of Style (11th ed.)
Status: Active — Portfolio under construction
Version: 2.0 — March 2026
CM-2026 is an independent biomedical research portfolio organized around a tractably scoped dissertation question:
Does preoperative initiation of multimodal non-opioid analgesia suppress perioperative central sensitization biomarkers and reduce CPSP incidence at 12 months in high-risk total knee arthroplasty patients?
The broader long-term research program — what are the mechanistic, pharmacological, and clinical determinants of acute-to-chronic pain transition in the surgical patient, and how can perioperative analgesic strategy be optimized at the population level? — frames the full 24-paper corpus from which the dissertation question is drawn.
The portfolio spans evidence mapping, mechanistic analysis, pharmacological assessment, and research design, terminating in a dissertation prospectus and doctoral pathway framework supporting both MD-PhD (MSTP) and standalone neuroscience PhD applications. It is the biomedical parallel to WP-2026, which covers U.S. legal-economic statecraft and sanctions enforcement architecture.
All documents are governed by CM-STYLE-01 v1.0, which specifies clinical register, GRADE evidence tradecraft, document architecture, and production standards.
Live Portfolio Index: CM-BIO-ARCH-01 v2.0 — Repository Architecture, Dissertation Prospectus, and Doctoral Pathway Framework
| Document | Title | Status |
|---|---|---|
| CM-BIO-ARCH-01 | Perioperative Pain Systems Research Portfolio: Repository Architecture, Dissertation Prospectus, and Doctoral Pathway Framework | Active v2.0 |
Papers are organized across five clusters. Each cluster feeds forward into the next. Status markers reflect current production state.
| ID | Title | Repository | Status |
|---|---|---|---|
| SR-01 | Perioperative Non-Opioid Analgesic Agents: A Scoping Review of Mechanisms, Clinical Efficacy, and Implementation Evidence | non-opioid-anesthesia-narrative-review | Complete |
| SR-02 | Acute-to-Chronic Pain Transition Following Major Surgery: A Scoping Review of Incidence, Risk Factors, and Mechanistic Pathways | — | Priority — Next Production |
| SR-03 | Perioperative Analgesic Strategy and Chronic Post-Surgical Pain in Total Knee Arthroplasty: A Scoping Review | tka-perioperative-review | Complete — Submission Ready |
| SR-04 | Perioperative Analgesic Strategy and Postoperative Pain Outcomes in Breast Reconstruction Surgery: A Scoping Review | Breast-Reconstruction-Analgesia-Review | Complete — Pre-Submission |
| SR-05 | Neuraxial and Regional Anesthesia Techniques and Chronic Post-Surgical Pain: A Scoping Review Across Procedure Categories | — | Priority |
| MA-01 | Analgesic Interventions and CPSP Incidence Reduction: A Systematic Review and Meta-Analysis | — | Immediate — Aim 2 Primary Deliverable |
| ID | Title | Repository | Status |
|---|---|---|---|
| ME-01 | Central Sensitization as the Mechanistic Driver of Chronic Post-Surgical Pain: An Analytical Review | — | Planned |
| ME-02 | Neuroinflammatory Pathways in Surgical Tissue Injury: Cytokine Cascades, Glial Activation, and Peripheral Sensitization | — | Planned |
| ME-03 | The Role of the HPA Axis and Surgical Stress Response in Postoperative Pain Chronification | — | Planned |
| ME-04 | Genetic and Epigenetic Determinants of Chronic Post-Surgical Pain Susceptibility: A Translational Analysis | — | Planned |
| ME-05 | Sex-Based Differences in Surgical Pain Chronification: Hormonal, Neurobiological, and Clinical Evidence | — | Planned |
| ID | Title | Repository | Status |
|---|---|---|---|
| PH-01 | Ketamine as a Perioperative Analgesic: NMDA Receptor Antagonism, Anti-Hyperalgesic Mechanisms, and Evidence for CPSP Reduction | — | Planned |
| PH-02 | Dexmedetomidine in Perioperative Analgesia: α2-Agonism, Sympatholysis, and Opioid-Sparing Evidence | — | Planned |
| PH-03 | Gabapentinoids in Perioperative Multimodal Analgesia: Mechanism, Efficacy, and Adverse Event Profile in CPSP Prevention | — | Planned |
| PH-04 | Intravenous Lidocaine Infusion and Systemic Analgesic Effects: Sodium Channel Blockade, Anti-Inflammatory Mechanisms, and Clinical Evidence | — | Planned |
| PH-05 | Opioid-Induced Hyperalgesia: Mechanistic Evidence, Clinical Recognition, and Implications for Perioperative Analgesic Protocol Design | — | Planned |
| ID | Title | Repository | Status |
|---|---|---|---|
| RD-01 | Risk Stratification for Chronic Post-Surgical Pain: A Proposed Preoperative Prediction Framework | — | Planned |
| RD-02 | Adaptive Trial Design for Perioperative Analgesic Protocol Optimization: A Research Design Proposal for CPSP Prevention | — | Planned |
| RD-03 | Biomarker Identification for Perioperative Pain Chronification Risk: A Translational Research Design Proposal | — | Planned |
| RD-04 | Implementation Science Framework for Perioperative Multimodal Analgesia: Barriers, Facilitators, and Quality Improvement Design | — | Planned |
| ID | Title | Repository | Status |
|---|---|---|---|
| PR-01 | Perioperative Analgesic Architecture and the Prevention of Chronic Post-Surgical Pain: A Dissertation Prospectus | CM-BIO-ARCH-01 v2.0 | Active v2.0 |
| PR-02 | Optimizing Perioperative Analgesic Strategy to Prevent Chronic Post-Surgical Pain: A Policy and Implementation Brief | — | Planned |
| PR-03 | Statement of Research Purpose: MD-PhD Application | — | Planned — Final Production |
| PR-04 | Statement of Research Purpose: Neuroscience PhD Application | — | Planned — Parallel Pathway |
| Phase | Papers | Feeds Into | Priority |
|---|---|---|---|
| 1 — Foundation | SR-01, SR-03, SR-04 | All clusters | Complete |
| 2 — Gap Definition | SR-02, SR-05 | ME cluster, RD-01, PR-01 | Immediate |
| 2b — Synthesis | MA-01 | RD-02, PR-01 | Immediate — parallel to SR-02 |
| 3 — Mechanism | ME-01, ME-02 | PH cluster, RD-02, PR-01, PR-04 | Next |
| 4 — Pharmacology | PH-01, PH-05 | RD-01, RD-02, PR-01 | Follow |
| 5 — Pharmacology cont. | PH-02, PH-03, PH-04, ME-03, ME-04, ME-05 | RD cluster | Mid-term |
| 6 — Design | RD-01, RD-02, RD-03, RD-04 | PR-01, PR-02 | Pre-application |
| 7 — Capstone | PR-01, PR-02, PR-03, PR-04 | MD-PhD and Neuroscience PhD applications | Terminal |
| Standard | Application |
|---|---|
| CM-STYLE-01 v1.0 | Clinical register, evidence tradecraft, document architecture — all documents |
| PRISMA-ScR / JBI | All scoping reviews (SR cluster) |
| PRISMA / Cochrane | Meta-analysis protocols (MA cluster) |
| ICH-GCP E6(R3) | Protocol and research design documents |
| GRADE methodology | Evidence grading throughout |
| CONSORT 2010 / STROBE 2007 | Trial and observational study design documents |
| AMA Manual of Style (11th ed.) | Citation format throughout |
| Repository | Domain |
|---|---|
| WP-2026 | U.S. legal-economic statecraft, sanctions enforcement architecture, competitive statecraft |
| tka-perioperative-review | SR-03 — TKA perioperative analgesia scoping review |
| Breast-Reconstruction-Analgesia-Review | SR-04 — Breast reconstruction analgesia scoping review |
| non-opioid-anesthesia-narrative-review | SR-01 — Non-opioid anesthesia narrative review |
| gbm-hybrid-mrna-framework | Independent — Glioblastoma hybrid mRNA framework |
| Premedical-Educational-Portfolio-Critical-Care-Physiology | Independent — Critical care physiology and ICU smart controller |
| Smart-NOA-Controller | Tool — Non-opioid anesthesia intelligent controller |
The following repositories represent independent scholarly work produced in parallel to CM-2026. They do not scaffold into the perioperative pain systems dissertation question but reflect active research output across adjacent biomedical domains.
| Repository | Domain | Status |
|---|---|---|
| gbm-hybrid-mrna-framework | Glioblastoma hybrid mRNA therapeutic framework | Active |
| Premedical-Educational-Portfolio-Critical-Care-Physiology | ICU and critical care physiology — clinical smart controller design and educational portfolio | Active |
| Repository | Description |
|---|---|
| Smart-NOA-Controller | Intelligent controller for non-opioid anesthesia protocol management — software artifact developed in parallel to SR-01 |
This repository contains independent scholarly work product produced by a premedical researcher. No document in this repository constitutes clinical advice, IRB protocol, or institutional policy. Documents involving systematic review methodology are governed by the relevant reporting standard listed above. No human subjects data are analyzed in any document in this repository.
All documents are uncontrolled copies. Verify current version before use.
CM-2026 · Perioperative Pain Systems Research Portfolio · Collin Blaine George · March 2026