This readme was written as instructions for another researcher to pick up on the work I left off.
hgrefFile = "refGene_hg19_sorted.txt" #prebuilt file
combine_patient_data_hgRef.build(hgrefFile)
first 5 lines of hg19:
585 NR_024540 chr1 - 14361 29370 29370 29370 11 14361,14969,15795,16606,16857,17232,17605,17914,18267,24737,29320, 14829,15038,15947,16765,17055,17368,17742,18061,18366,24891,29370, 0 WASH7P unk unk -1,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,
585 NR_026818 chr1 - 34610 36081 36081 36081 3 34610,35276,35720, 35174,35481,36081, 0 FAM138A unk unk -1,-1,-1,
585 NR_026820 chr1 - 34610 36081 36081 36081 3 34610,35276,35720, 35174,35481,36081, 0 FAM138F unk unk -1,-1,-1,
585 NM_001005484 chr1 + 69090 70008 69090 70008 1 69090, 70008, 0 OR4F5 cmpl cmpl 0,
587 NR_028322 chr1 + 323891 328581 328581 328581 3 323891,324287,324438, 324060,324345,328581, 0 LOC100132287 unk unk -1,-1,-1,
Description of columns can be read up on here
https://genome.ucsc.edu/cgi-bin/hgTables?db=hg19&hgta_group=genes&hgta_track=refGene&hgta_table=refGene&hgta_doSchema=describe+table+schema
We only need the geneId, chromosome number, strand, transcription start and stop points
columns 1,2,3,4,5 respectively
combine_patient_data_hgRef.build() uses the prebuilt patient files (inside the directory "patient_data"), labeled as
ff870342-f0d6-4450-8f9c-344c046a0baf.pcawg_consensus_1.6.161116.somatic.sv.bedpe
ffa976f0-aa60-4867-842e-361afa7d68ac.pcawg_consensus_1.6.161116.somatic.sv.bedpe
ffad9288-c622-11e3-bf01-24c6515278c0.pcawg_consensus_1.6.161116.somatic.sv.bedpe
.
.
.
(those file prefixes (up to .pcawg) will be used later)
and we create a new directory, called "Referenced_patient_data" inside your current working directory.
After this process runs (for the size of this data, it takes approximately 10-12 minutes), the "Referenced_patient_data" directory will contain individual files with the same file prefix as the corresponding patient data, but with only the valid gene fusions listed. For example:
#first 5 lines (of ~50 lines) of 0bd3a230-531e-44aa-9999-b8ed8da0176b.pcawg_consensus_1.6.161116.somatic.sv.bedpe
chrom1 start1 end1 chrom2 start2 end2 sv_id pe_support strand1 strand2 svclass svmethod
11 82798867 82798868 11 82936093 82936094 SVMERGE10 37 + - DEL SNOWMAN_BRASS_dRANGER_DELLY
12 115046363 115046364 4 56334945 56334946 SVMERGE34 35 - + TRA SNOWMAN_BRASS_dRANGER_DELLY
12 115046403 115046404 4 72591306 72591307 SVMERGE42 32 + - TRA SNOWMAN_BRASS_dRANGER_DELLY
12 118147063 118147064 13 54442327 54442328 SVMERGE38 12 - - TRA SNOWMAN_BRASS_DELLY
produces
geneA geneA_orientation geneB geneB_orientation chr1 position chr1_orientation chr2 position chr2_orientation
./patient_data/0bd3a230-531e-44aa-9999-b8ed8da0176b.pcawg_consensus_1.6.161116.somatic.sv.bedpe
KSR2 - PCDH9 - chr12 118147303 + chr13 67542094 -
CLDN14 - DYRK1A + chr21 37873660 - chr21 38850309 -
DYRK1A + TMPRSS2 - chr21 38846232 - chr21 42868379 -
DYRK1A + TMPRSS2 - chr21 38846936 + chr21 42869068 +
DYRK1A + ERG - chr21 38850232 + chr21 39893645 +
AFF1 + INTS12 - chr4 88026639 - chr4 106603789 -
INTS12 - KIAA1429 - chr4 106603808 + chr8 95541749 -
That's the entire tsv file. First line column headers, second line is the original source file, followed by the data
So looking at this example, this patient has 7 gene fusions.
The first one contains genes KSR2 and PCDH9 with the breakpoint on KSR2 located at 118147303 and the breakpoint on PDCH9 located on 67542094. These locations will be used later.
This step uses all of the following prexisting files. (first 5 lines included)
#first 5 lines
chr1 HAVANA gene 11869 14412 . + . gene_id "ENSG00000223972.4"; transcript_id "ENSG00000223972.4"; gene_type "pseudogene"; gene_status "KNOWN"; gene_name "DDX11L1"; transcript_type "pseudogene"; transcript_status "KNOWN"; transcript_name "DDX11L1"; level 2; havana_gene "OTTHUMG00000000961.2";
chr1 HAVANA transcript 11869 14409 . + . gene_id "ENSG00000223972.4"; transcript_id "ENST00000456328.2"; gene_type "pseudogene"; gene_status "KNOWN"; gene_name "DDX11L1"; transcript_type "processed_transcript"; transcript_status "KNOWN"; transcript_name "DDX11L1-002"; level 2; tag "basic"; havana_gene "OTTHUMG00000000961.2"; havana_transcript "OTTHUMT00000362751.1";
chr1 HAVANA exon 11869 12227 . + . gene_id "ENSG00000223972.4"; transcript_id "ENST00000456328.2"; gene_type "pseudogene"; gene_status "KNOWN"; gene_name "DDX11L1"; transcript_type "processed_transcript"; transcript_status "KNOWN"; transcript_name "DDX11L1-002"; exon_number 1; exon_id "ENSE00002234944.1"; level 2; tag "basic"; havana_gene "OTTHUMG00000000961.2"; havana_transcript "OTTHUMT00000362751.1";
chr1 HAVANA exon 12613 12721 . + . gene_id "ENSG00000223972.4"; transcript_id "ENST00000456328.2"; gene_type "pseudogene"; gene_status "KNOWN"; gene_name "DDX11L1"; transcript_type "processed_transcript"; transcript_status "KNOWN"; transcript_name "DDX11L1-002"; exon_number 2; exon_id "ENSE00003582793.1"; level 2; tag "basic"; havana_gene "OTTHUMG00000000961.2"; havana_transcript "OTTHUMT00000362751.1";
chr1 HAVANA exon 13221 14409 . + . gene_id "ENSG00000223972.4"; transcript_id "ENST00000456328.2"; gene_type "pseudogene"; gene_status "KNOWN"; gene_name "DDX11L1"; transcript_type "processed_transcript"; transcript_status "KNOWN"; transcript_name "DDX11L1-002"; exon_number 3; exon_id "ENSE00002312635.1"; level 2; tag "basic"; havana_gene "OTTHUMG00000000961.2"; havana_transcript "OTTHUMT00000362751.1";
Getting a better understanding of this file is important
You'll need to talk to Dr. Yang about this file.
The issue is this:
You see how the 3rd entry in each line is "gene", "transcript", "exon", "exon", "exon" in that order?
So you'll see later that we're looking at the particular RNA-seq value for each exon. However, in the later file that has that data, the exons are labeled by exon number, which, if you ctrl-f "exon_number", you'll see is contained in each line that starts with "exon". However(!), it doesn't occur in this subset, but occassionally you'll get exons on the same gene that have the same number. There's an attribute called exon_id, unfortunately, the RNA-seq value file doesn't list by id. The reason this is a problem is because, while the RNA-seq file will just have one value for one exon number (per patient), the location of that exon (cited in this file) varies for different exons, which will affect which side of the gene breakpoint they are, and therefore affect the results of your data. That's the best I can explain it over text, Dr. Yang can help you further with this.
feature 001b3264-ad8f-4170-a7c4-edcb51c83d54 0031a146-0bbb-4430-bb8c-6de453881452 003de740-7ed3-4a65-b742-3cb1762dcd0d 006b0868-0c85-436d-8aeb-67016209d25f 0077fe82-ffcb-11e4-bffd-eef4431ac25100b3b72b-0ac4-4016-bfa2-0bfcd5645d4f 00bf2bb0-ff51-11e4-b122-8dbd36d7215d 012774c4-d4c0-11e4-93a5-c688eda0acae 012d796e-4728-4317-ab5d-0f18324824b6 01541338-d486-11e4-b810-b148b6cf0ce0 017fcb68-d4e5-11e4-a135-b98e7fc89d10 01a78d1f-65fd-4b33-8dcc-d25d679a6f6c 01d74497-4980-4665-9d3e-fce428c7354d 01ece777-02ae-4657-b295-1943959f5e1e 022f6f2a-f888-11e4-a791-8475fb958afb 02a9b3c2-d48c-11e4-bfe4-91ef71d5166a 02f756c2-dd33-11e4-ba49-b4bec254ba06 030809ad-2009-424d-be47-7184c72393e1030868b4-2b46-4897-a03c-ec60c2bb71a5 0324c3ce-3e7a-4ecd-87ef-3d02b591c0b0 03c2f6ba-caef-41e1-ad3e-7a0a76d9f4f7 04200fa2-d4b0-11e4-987f-939bd1ed9301 04722d26-ffc3-11e4-b2f2-b7a7e90c656f 04850a1e-f5a3-4d36-a2c0-bfb6fb8b8b16 0491ad0b-0336-4d9c-8dfa-b40d1a6db195 04efdb66-dd3d-11e4-af75-1225c254ba06 056cf0e4-d840-406d-993a-65017a39f071 0571951e-e203-11e4-9a2b-13ff4a963160 057da4ba-421e-4f39-afa8-c7de2ca665e2 05824e07-d6cf-4022-868a-fc2b38fc9c53 05caea96-dd31-11e4-8808-f884c254ba0605ed234e-d229-11e4-8061-057ffb958afb 0601984a-7edc-4604-ab3a-7011ffb71035 061d4538-ff51-11e4-a527-af0ee93ac751 0675d638-d483-11e4-bfa0-bb0e4b69f186 0676f821-fcbe-46b1-874f-4050d3a47b54 06849956-e598-4660-9562-24d8ae5e7616 06c25514-28c4-4140-8db5-0a1c36df77a9 06e17625-2cf7-4ba5-b47d-5fb1091a3c61 07075f5c-d8a5-40a5-bd58-49715cfe7543 07316130-3eec-4d63-86cf-cdf167dc5bb4 07358ca8-7f72-4848-a795-847edb7a1c2d 0753d4dd-03e2-4b5f-809a-f250485271c2 079d974a-6a6d-4933-87a1-13e11e37320d07b53428-01cd-48f8-aee2-8dc47e84ccee 07dd2392-8d59-45f5-bae1-290184c85421 08025318-c284-413e-af82-e2eba40c4013 08150c96-fed8-11e4-9fc4-ec33203e5f3b 0821f0f7-09fc-47f0-9695-9093a831cca1 0825fbce-6bc9-4fdf-9587-b52194b95b03 0882c908-0026-11e5-8630-ddcca00eb6df 0895c75e-e1fb-11e4-8e7f-ef4a1a0a8610 08bd1ad7-3b09-4b44-810a-ef69235d79bb 09209cb3-2a37-4be8-a18b-e187ddf2b000 09503f30-0b72-47b0-82a3-1c458fbe35d6 09a716c4-ff70-11e4-b88b-afde27eb4be3 09b8da46-11cf-40f1-8811-670bdb3a62970a2585da-dd34-11e4-9a98-3d75c254ba06 0a59f9f4-e1db-11e4-9182-a543a5ed4642 0b4d443d-cfa8-42c0-aaf9-be947584ba59 0b5853ab-e59b-452e-8142-6516bc7102e2 0b88c264-e1f0-11e4-98e2-042e9d4f5ec7 0bbb69d8-d496-11e4-8cfd-92e71275c5fd 0c1e8a2c-dd38-11e4-aef9-76afc254ba06 0c4a2070-ffd3-11e4-8602-b58db992e84e 0c559e08-ffd5-11e4-a7aa-fc3d3b93e46a 0c66b516-430d-4826-ab75-e0a12a587299 0cf7077e-d4c5-11e4-8811-a30346a24af7 0d29200e-946b-4ec1-990f-ddb7443b5c9e 0d5374cd-0dc1-440f-9e43-c026cfb950b90d743699-ca9a-4b5c-bc8d-ec8a945f1a58 0d81e1bc-e1e2-11e4-a48b-e13b90e4cd7a 0dbd1852-e47e-40bd-91e4-c28d45024809 0e2b718a-e757-4aee-a437-a9b6dbb0ec74 0e53a110-3039-4099-861a-0ed98a92835b 0e7acc13-fb8d-4ccc-b1d4-4ccc24417ead 0e9bd4f0-ff8c-11e4-b942-88d0c142bba4 0eeb2cb0-fd87-4d13-951d-0a6892f2ff20 0f2ec289-60be-4383-8747-490b775bf5cc 0f4809cc-d4cc-11e4-8481-bb8914dce1a0 0f90ba38-4572-49d7-9d78-b12657d39c6a 0f9810da-dd45-11e4-9f99-0cbfc254ba06 0fa2b935-99e8-4466-a86e-9bbb1e3657f30fa577ab-536c-476a-8a81-3beee5f5635e 0fdb3144-4537-482a-ad2a-502c313ededd 102fdc84-e1f6-11e4-b21b-b8030ae66825 10ba899c-0ca5-49bd-b14f-366e2126f953 116ad953-e0ee-417c-88d2-6c35e621cdbf 11727cc2-e425-46b2-91db-e46f97a6551a 1185d896-1731-4333-8fe2-51a5815e4d10 119ad01f-71d8-493b-9f69-189a7a26329f 11ac03d0-ffbf-11e4-970e-9372621c0793 11ad1d34-dee3-42f9-9b7d-13ba47c1d205 120a244c-39cf-4e04-ab6a-2d2f719a8e96 120ff28b-5864-40c4-8bad-a0dfc5deccd5 122ec841-45fc-4a68-b69c-b9b91ddef8ae1231589e-c1f7-4281-b23d-c19db1d60122 125737ba-dd31-11e4-89b6-1786c254ba06 126d9772-ad58-48c4-b5b8-def3bec1ea03 126ef0b6-d21f-11e4-aac5-00a5fb958afb 1289fcab-cba3-4c76-a86c-c8469d781b74 12f95f04-dd36-11e4-98e6-a292c254ba06 13043f5e-f25c-4274-a9b0-4a763c42e294 13369afc-f868-11e4-b11f-fc4ffb958afb 13545c04-8979-4dac-9bdb-8de8964af321 135c8b0a-d4ae-11e4-8998-831dbabfa7f2 13636056-ff60-11e4-aaa2-88de6bd43ef4 13b0aa64-ff65-11e4-b5a4-dc0c5d4dd56f 13f7e6ed-319b-4c71-9647-74647583b6e91426e74a-b04a-4a1d-a7c4-62db40551bce 14502ddf-7933-4be1-9a9b-32fd132f328e 14a0e10e-fb5b-11e4-be1c-aa5fbb065116 14a7747e-fb5b-11e4-9afb-8f474ede6325 14a8ac7c-fb5b-11e4-b5c9-a73ef9f2fa35 14ab6b92-fb5b-11e4-a7d4-b5dfae3707ff 14ae76d4-fb5b-11e4-9229-a731ecf020db 14aeac30-fb5b-11e4-a882-f4b5c43f9dae 14aee240-fb5b-11e4-9282-96ea0139f161 14af1706-fb5b-11e4-b62e-afc908aa4649 14af4c62-fb5b-11e4-ad54-8bf8def52fcd 14b2100a-fb5b-11e4-a684-a5646e8ec24d 14b55d5a-fb5b-11e4-896b-f5d5f735bfba14b5922a-fb5b-11e4-9ede-e1e5a89258c4 14b5c934-fb5b-11e4-8792-ddf4d5a599c8 14b5fe40-fb5b-11e4-bf1d-e865d41c85c2 14b634f0-fb5b-11e4-8874-8726c17ef450 14b66952-fb5b-11e4-ad22-aed855313a81 14b69ecc-fb5b-11e4-a314-c209a433eefc 14b8d41c-fb5b-11e4-b803-a205c55e314a 14b90af4-fb5b-11e4-830b-93f0f6838186 14ba8582-fb5b-11e4-92f7-a97e13df41ff 14babc46-fb5b-11e4-9a9c-d57f058fd087 14baf2e2-fb5b-11e4-b5ec-a5d7af3b683c 14bb28ca-fb5b-11e4-a0dc-8b002347468f 14bb5fd4-fb5b-11e4-b077-87ca92e7994814c918fd-9aa5-473d-bbfc-4c71928f58d6 14d0834d-bce7-45f5-a2e3-d569ec3a910f 14d7fc2a-cece-11e4-9ee6-b86cfb958afb 1538d0dc-d4cc-11e4-bed8-c4badb6df2b1 1562f565-a000-437c-a9c8-f058639023b4 15787c0c-fef0-11e4-8e24-e504abb0f656 15e8ce8a-ff6d-11e4-881e-e9df2abc3fe7 165efa6b-5c3d-4a42-99e3-3b915f2977f4 16996d19-a008-453e-bacd-cde14c36624e 16a20bcc-fb5b-11e4-98d9-91243708b162 16a25b22-fb5b-11e4-9aa7-8d24202abdd6 16a2943e-fb5b-11e4-8568-c2aab4d975f8 16a2cf26-fb5b-11e4-95e9-8c72cd75426a16a306bc-fb5b-11e4-9f48-b2801de48b70 16a3153e-0478-470c-8a0e-1d98a19b2cd5 16a33df8-fb5b-11e4-81b1-9f6b47467ea2 16a37534-fb5b-11e4-b40c-bff888a43a29 16a3ad06-fb5b-11e4-8fc7-9ba7e58e591a 16d4e0d2-e1f8-11e4-8244-cdce180f7476 1753d424-ffbb-11e4-8085-e98bb6d8200a 1754a4be-ff7d-11e4-991d-bc5c3bf01685 175ea5b5-5e77-4258-a8b3-885d2a5671f5 175ea6b7-ff2c-494f-8e80-9a950952c330 1763262a-1ceb-4ed5-a589-36968e96b1e1 17b5d7fa-fb5b-11e4-add6-aba14757f090 17b625c0-fb5b-11e4-a15b-8545f991a27c17b91a89-ce8e-4064-a1d8-9be025393c63 17cc61f4-e1e9-11e4-9867-fed46deb50a1 17d9a420-ad46-43e1-8e23-3bab9e5a13be 18187492-da4a-4371-b444-b6fcd54edd5c 1828ef15-79e4-47d3-8e8e-f777ede8c278 1859f525-2e37-425e-ae83-31c1c362d3ed 18a7818a-f6e3-11e4-b54b-deaffb958afb 194e5ef2-9956-4e54-a823-99dca46df5f3 195ab0e4-dd42-11e4-96a9-104cc254ba06 1989ab2c-d449-4de9-a65e-a9c291b1bf97 198e6983-db2d-4481-a952-03137da40c1f 1a008528-fb5b-11e4-8992-c4f235609eea 1a01acc8-fb5b-11e4-a1ec-df9c4c0cae241a01e72e-fb5b-11e4-ab9c-d91320453ceb 1a02218a-fb5b-11e4-9c31-b91df87bbbdd 1a025934-fb5b-11e4-a1c8-999aa1b5c05a 1a0293fe-fb5b-11e4-a2db-82eaae4d6b8b 1a02cc3e-fb5b-11e4-b902-bc317cfb2f9f 1a0304e2-fb5b-11e4-9180-a3b4f91843cc 1a045c86-f42d-48df-9f00-b26df2863c32 1a7e9b2d-c4e6-4372-9b95-a509a30f0d26 1a9aca14-7146-482d-bf51-f93646936d2c 1b0430a0-fb5b-11e4-ba53-cf9dfe34127f 1b047e52-fb5b-11e4-8701-f8fd5c65d50e 1b04b5f2-fb5b-11e4-80f9-a520306c556a 1b2113a6-d237-4316-9705-1c7edf76b0f41b34fe44-0666-49a9-8074-27814eaa1bb6 1b6cce58-ffa7-11e4-beeb-c5cd29957139 1b88b184-bc65-4406-a286-0fc94d61eea4 1ba12cde-000b-11e5-b3cc-d2c9614fe582 1bff461b-2b66-458a-ab2a-a83d6cfbeff2 1c22f1d2-2137-4b12-951d-5215384ef735 1c3d59a6-d4a0-11e4-b25f-cbe2eebec115 1c8506ff-52ae-4a1a-a751-4870080c126d 1c88a8be-8daf-43ad-b879-ed4f3aefe51b 1d1b0ff4-ff6f-11e4-9f9a-b366b3677e8f 1d29e05a-fb5b-11e4-8878-ae02b98aa182 1d2a2ede-fb5b-11e4-b3a4-beb8182cada3 1d2a685e-fb5b-11e4-be8a-c7f9c65b15891d2aa10c-fb5b-11e4-abd3-8ffa4c7e7dfe 1d38a970-4348-446b-8ae5-9c4336281e8d 1d3e2f0e-ff8b-11e4-8a42-ec2ed169c35c 1d811d54-caa1-41f3-bfc2-400eebdd97ef 1d8bab8e-338a-4c52-aefe-c9ee0bac6b73 1da07641-0d08-4b21-872d-484ab49873ad 1dae89cf-4abb-4af6-9147-6d12d95204e6 1db38abf-81e5-4e04-842e-6779eb30da8a 1db4291e-d4bd-11e4-add8-ce19644e4bcf 1e2cc863-1123-451c-a295-0323fb421188 1e5277ca-41f6-41a0-8300-4a20e10edac8 1e73ea14-fb5b-11e4-b5f6-b9232712c614 1e743be0-fb5b-11e4-92d0-93c5c32e018e1e7473ee-fb5b-11e4-8364-b042c5656719 1e78604e-fb5b-11e4-8c80-8b585b68a3bc 1e789636-fb5b-11e4-ab35-d5f0b89b4d05 1e791309-0b14-45ff-9787-0747938d16c6 1e9b06dd-20b8-4401-9b89-c084d18a0ade 1ead4c27-7e6c-4823-91e0-2cb457bc52db 1ecaedbc-ff45-11e4-9d28-a1fd7c86f8d8 1ee56807-99fd-4b73-8edd-5c0f440cffc1 1ee804b2-dd3d-11e4-aaa5-b426c254ba06 1f1b8abd-9770-42eb-b4dd-d26f9108ae7e 1f392620-0025-11e5-9856-b925193391fe 1f575bee-e6b5-4a37-b1f9-9c849f28fd3a 1f60640c-fb5b-11e4-a29a-f4fac632993e1f60b150-fb5b-11e4-9d66-8a30e76c1f53 1f62dafc-fb5b-11e4-8144-dcd208a5e4cb 1f631fb2-fb5b-11e4-a3cb-edcf0978e0a5 1f65aef8-fb5b-11e4-b2a0-ca263bca6e71 1f69bf95-bc45-4075-be67-58faa12e020f 1f9b7ad8-ce89-4e73-baa1-2289e2d05f1f 1f9d6213-cdc5-4572-8a02-ba218e2b616b 202847b8-fee6-11e4-97d3-fff1082e6d33 20337a90-fb5b-11e4-a5ce-aa7b2483d981 2033c748-fb5b-11e4-9b97-b6547f52082e 2033ff24-fb5b-11e4-9662-bc72333902da 20343606-fb5b-11e4-8ec3-f50899c76d54 2036b4c4-d4b6-11e4-b094-db08d77cf7422043082a-ff66-11e4-82b8-fc7cfe6f3007 204896c3-d05d-4224-8846-e02a647168f9 20b8ffca-ff8a-11e4-8c05-b5b7814309a7 20cb64c6-d4a1-11e4-ab9c-a227e3b2df77 20ecf58a-ffe1-11e4-899a-b649ff3cf04b 210b2ce2-fb5b-11e4-88d0-8ed828247c60 210b78fa-fb5b-11e4-ad87-cec91de81001 210d7786-fb5b-11e4-8eb6-d800882a7303 210dcfa6-fb5b-11e4-a6b8-b064e848d48b 210e06b0-fb5b-11e4-8e34-8caf43d307f5 2153611a-ff34-11e4-8ba6-e210e77b5174 217fe838-ff67-11e4-a6f2-ae51977a85a9 21d93646-2bdf-45a5-83c5-1f5faa3dd49d21ed5056-dd31-11e4-9b95-a486c254ba06 22063ad1-ba0d-4fb9-a5da-9b9d0e938a96 221fe4a9-a184-4667-a5d5-80d055b25e90 22359528-d4c1-11e4-a37c-ac70ba102df5 22ad660a-ff9d-11e4-a37e-fc2be4372cd0 22f321c6-ff3f-11e4-8e8b-f8a0800c69f0 23242ae2-ff6b-11e4-be10-f706f87fb156 237e750e-dd35-11e4-8253-9885c254ba06 2385084f-681b-49a3-a78f-6975a03f419b 2391dddd-efea-4f5c-8472-0e718bb6b978 23e76a4f-9e4c-4aed-a46d-d9cbc1336250 240dbc93-01eb-47f7-9f36-e91e013a9203 2417ab57-25f5-46f3-847f-1b48c13bd0b5242bb83a-dd3b-11e4-9b69-2be3c254ba06 2430d07e-6cee-4c99-a423-ed4dfb4b8c5e 24632768-1d4e-46c6-9f82-8d6ef35058db 24904d08-08a8-49b8-8e8b-666468361c69 24d494cf-e21b-4de8-9cc0-dd5495212641 24f4ba02-dd3e-11e4-ac5c-e235c254ba06 25cf7772-e1e0-11e4-b288-937682ebcdd5 25f74f74-9df1-4f9f-be0d-b2f32077c08b 263668a7-e877-4311-9c76-13cf23b1e811 26397d20-2a82-46ad-b9d1-2755ca92f3d3 26565a30-ff45-11e4-bd82-f4e779f02c12 26694d3c-d4c7-11e4-8f91-f3138aa03009 266adbd0-d219-11e4-9fa1-3291fb958afb2672fb9b-4e13-44cb-87a2-c50020abe3c0 267d6eaa-29ab-47cc-9a58-75b0d90ea774 268bd9b8-e1df-11e4-8ae8-2d421a0a8610 26961e76-ff73-11e4-a4c6-d2db61aa0132 26a356ed-80e5-49dc-b203-6c8e0d3d3aa0 26b43472-1e5c-44d4-a8ea-92fbc0f28b48 26cebcea-f8a2-11e4-8f29-ba58fb958afb 26d91acf-a12d-4970-a37c-75b09410ed55 271a2df3-78dc-4877-ad3a-e479965b2e0e 2745bf28-d491-11e4-9ea7-c8f62841ab9b 2747e8fa-33b9-4550-b989-eb41bcb82d4a 27534534-fc67-42d0-a235-2258221aee45 275782c6-ff3e-11e4-b2df-c21fa0f9f2df27629399-18f2-421c-b0b0-f0201d542189 2772db65-145c-491d-b49f-fe37bbc2d90a 27dd46c2-dd38-11e4-afb0-c9b0c254ba06 27e3df71-f836-41d8-9ffe-628106114963 286f6f1a-9350-4822-a08e-7f5288068762 288b9bce-d49f-11e4-8b5c-dbf3b064de61 289d70be-aa36-438f-83be-6f8e29b44981 28fd3732-f152-46c4-bedf-4c9ebf0f566a 2913df27-597d-4ee0-a0a1-e4f8a6c819fe 29373ffe-b51b-4a14-a2e8-16dae47d1263 294e3452-27a7-42d2-9f60-34a69fada97e 29507bea-bf84-4b4e-902b-e7e42d70ca31 2993b1d1-283a-479e-8f74-8d6295a41f3129ccf0cd-ef4e-4ac4-b862-4e5546762c1d 29e7d909-80ac-4bba-af43-f0d1f59f017d 2a3444cc-ff46-11e4-8720-8031a068f73f 2ab8dfcc-ff4e-11e4-afc9-80ac9354a606 2abb0663-ee27-4f56-b9a3-bf394a802a7d 2b0acc47-842d-41f8-a631-3af0005c2ff0 2b28225e-6c7c-44b9-b06c-1eef0b0a84bf 2b45f85d-97ba-49cf-9126-a73a841e7310 2b7320b2-5272-4171-98b5-1a89bbdb3bb8 2b791aa0-e1dd-11e4-8172-820478cf9794 2b7cee9b-2ab2-49f6-8c80-7e5ba9351a59 2b836282-fff4-11e4-a4ef-f1141f0adda1 2ba7311f-118b-48e3-8d40-758a5be21cd22bb34d62-edba-4ccc-a1a0-f3315ccf649a 2be4609a-ffd2-11e4-9d32-ff35fc25fa63 2bf0da6e-d499-11e4-934a-c832350487b0 2bf49880-dd44-11e4-973c-bba9c254ba06 2c2c6276-d234-11e4-82e9-90a0fb958afb 2cc4814c-dd41-11e4-9754-6df6c154ba06 2cdaa358-cba5-4c7c-bd9a-6a459ff0c7ee 2cea0220-e1fe-11e4-80d6-9672ba4f2a7a 2cec92cb-1c5e-45d5-92ed-5b9cba4dbeee 2d1855be-6a4f-423e-94c3-6135813296b9 2d2358aa-e62e-4d38-bcb3-94faac6ad47b 2d876b3e-f666-418e-85df-3a27cf64aaa2 2dc767cc-e1fa-11e4-9449-d8ae9e91f09a2dcde474-3cb9-45a6-8d0a-49bfe684fd50 2e172001-1560-4bfc-9f26-adb55ec87953 2e3c96c2-dd3c-11e4-83c5-0de4c254ba06 2e52bc09-1ac8-41ec-b0f0-31330bd4cf42 2ef021c6-29df-4730-99dc-0104ef01b18c 2ef678a2-aced-48e9-a29d-9c4091d272fc 2f09698e-48ed-41da-ac82-70280e092fde 2f5c7f1c-4c6d-4fa9-85b5-f356e98f7712 2f68cf35-90da-4462-88a3-5c8e937693bf 2f96c503-b55a-422b-9339-f8b6c06f2caf 2fc626b0-bfdd-43c4-bc88-078f1c89d513 2fe8ac19-48e7-4bad-9437-523c9e59f77c 3012b80a-fac4-11e4-ad70-9e3cd51b4cbf3014e27e-fac4-11e4-8849-d3f7030f0fb6 30162e90-fac4-11e4-9f4a-f11b7a658a33 301a82d8-fac4-11e4-a225-8b392a9c2baf 30439a68-84d3-4dfe-b066-34bca90265a6 304f6e92-ff85-11e4-884f-b32df3680d0a 30d7cac2-65d4-49ae-8aff-992a2e4e3617 30e90a96-dd31-11e4-856d-ad87c254ba06 31182ab2-ff44-11e4-b722-efa3af17374f 31615db2-e1f9-11e4-9c66-c7ab578961f5 31aa9f73-2a1c-4d33-951e-66d454997132 31c7f01e-ff3f-11e4-bf78-f96c02c4f620 31deb120-ffce-11e4-8f12-ffbe98d14f5f 320e709a-f88f-11e4-a394-5c93fb958afb32a5f9c4-fac4-11e4-9879-bbd56bfa70c6 32a66382-fac4-11e4-a04c-bf8c10b1c86f 32a69bc2-fac4-11e4-940a-fb28b8d4c9fb 32a6d268-fac4-11e4-805a-e70d0610eb0d 32d9855a-d495-11e4-bf16-ceef33a92ee6 32fa724c-ffc4-11e4-81ce-fc4721dbe7b1 3308c5b7-0b5e-4c6a-a1e9-42f8b0de9266 337e9482-fac4-11e4-a5d9-94e6792a2aa2 337f0a0c-fac4-11e4-8517-946de6b87b88 337f4300-fac4-11e4-89f1-b72e4d333102 337f7a6e-fac4-11e4-a840-f2ae635210a5 342ff523-e6ec-439a-bada-f8ae45907aa5 3475d243-435d-4e5b-bae7-37ab4bce7212347d7c6a-d493-11e4-9b5e-bdd51dfc2864 34b035ca-d024-4556-931b-02fcbd0ee18e 34e82f86-8232-4e31-8d54-3a931fe0be57 34ea2ebc-fac4-11e4-920d-fa904d2f9676 34ea9aa0-fac4-11e4-93a8-a584893813ae 34ee5744-fac4-11e4-81d0-a80b35547ce0 34ee8f84-fac4-11e4-8177-d02c5ffcc9f3 35045438-ffb8-11e4-a89b-b0159f21fab7 355c2422-e200-11e4-a1d2-c0f04a963160 35bec928-f765-42f7-a80b-3cbd71431528 362e4ba1-1954-4582-9bd2-ffadabcbafdb 364fc462-ff4f-11e4-9b9b-fa823a6d7cb3 3663419c-0d63-46bc-89fc-eaf1dabd6483366e1ef1-4909-460c-a1cf-4999c445cf11 36a1518c-f870-11e4-b685-8186fb958afb 36a4f790-64f7-4840-b8c0-f0d469ddb22c 36b24319-2f00-4107-9991-6f277fa8b25d 36f62b20-fac4-11e4-ba89-dec67f19d7b2 36f679cc-fac4-11e4-ae38-d56e89b87c59 36f6b2fc-fac4-11e4-a0df-9b1ea73c88f4 36f6ea7e-fac4-11e4-81d6-bdfb5a58ca2e 36f7208e-fac4-11e4-a6b0-913bf7e3cebe 36f75626-fac4-11e4-9375-97fb8510ec56 36f78ca4-fac4-11e4-a3be-f1f6eeb05b15 36f7c2b4-fac4-11e4-993b-c3946b16e154 36f7f748-fac4-11e4-903c-8afa4dd1d7e036fa7e50-fac4-11e4-a57d-9f1dd6949bfc 36fab460-fac4-11e4-9811-d2c68a8d86f8 36fbfc30-fac4-11e4-95f8-aaa54e27e6fc 36fc32e0-fac4-11e4-a183-ed48354b112c 36fc6a8a-fac4-11e4-b186-9ac6afc08177 36fead86-fac4-11e4-83b3-8d54cdd97363 36fee396-fac4-11e4-acc3-aefd018053c3 36ff1992-fac4-11e4-bcf7-929577269465 36ff5024-fac4-11e4-929d-c56b6ea01c2b 36ff8620-fac4-11e4-adbf-9dbfb10dca29 36ffbe24-fac4-11e4-b4ee-a340e6c33d13 37040fb8-e1da-11e4-add5-d2d34a963160 378e4c10-ffa2-11e4-9dd9-a61e2a99cfc8379624ed-3584-48af-a1af-b5d308dfc063 37b2a63d-358d-4a3c-9f21-a6ace3f8ebb7 37c04392-ffe2-11e4-9e6a-ea867d98da93 37d0020a-d4d1-11e4-88e1-955970b4c781 380afc66-fac4-11e4-9598-cc52fce4df16 380b8168-fac4-11e4-80c0-8c93d8f6ddf9 380bb8e0-fac4-11e4-a947-f8ae2e036f7e 380bf148-fac4-11e4-b4bc-84723f15d140 380c26cc-fac4-11e4-8645-8d3aa85397bf 380d77ea-ff86-11e4-afa2-d9d343b91d6f 38662220-e1ed-11e4-bc51-c31d4fb570f9 387891d2-d4b7-11e4-9b98-9aa67e9e188f 3884033a-ff6b-11e4-b372-d75238e0fd8f38d59ae8-fac4-11e4-a87b-d08b02b75264 38d87074-fac4-11e4-8bed-da360acca5d8 38d8a77e-fac4-11e4-bf70-af997bfd3b8c 38d8def6-fac4-11e4-a17d-e340dd3fc5b4 38da00ce-fac4-11e4-b332-c3d5dcbf7793 38f55f38-dd3a-11e4-8250-fdd5c254ba06 390ec618-ff80-11e4-997a-edf3e11939df 391ec750-ff3c-11e4-a7ba-aed08691bbaf 3945fe90-44f2-438a-a8e6-fb89b2003499 39bd2462-fac4-11e4-8ad1-f46b31c7ce59 39bd74b2-fac4-11e4-83a9-b58125277152 39bdad42-fac4-11e4-8bac-900a5eeedd92 39bde55a-fac4-11e4-bf4f-ca8a525beaa839be1b42-fac4-11e4-a805-c3354473b2ba 39c16252-fac4-11e4-b5d7-b8897afb4964 39c19baa-fac4-11e4-8f62-de671eafba69 39c1d318-fac4-11e4-90a6-9b2f0854acda 39c26677-34e2-4f3c-ba7e-efaf82cfc998 3a0d4edb-5812-42bf-8f3d-cd03c62edf32 3a534ff8-e1f3-11e4-b02d-79a71a8ef4d2 3a54b8ca-c71f-4ced-a5e7-b7f6d61d12f1 3a866db8-ff3d-11e4-a05c-875c51a43342 3abb0bc9-3124-4538-add6-8ab9c1b3cc85 3acd6c0e-fac4-11e4-b02e-942914f555f9 3acf2ba2-fac4-11e4-a54d-dfcb246dba3f 3acf641e-fac4-11e4-8976-af06bd6245bb3acf9d4e-fac4-11e4-a567-ecd2101f4aab 3acfd3fe-fac4-11e4-92c8-9409e69e3147 3ad09c76-fac4-11e4-a4ef-db5aaf280495 3ad0d254-fac4-11e4-8237-a775aaa38e96 3ad1083c-fac4-11e4-ba00-e5a33633c1ee 3b2441cf-0bb2-4f74-9e0f-0f55feb209a9 3b407ebe-d4b4-11e4-aba9-9558183f3b75 3b4d1b9f-8210-4c38-831c-dee85865dc08 3b8f2742-d232-49e4-8fab-e02f18ee80b9 3be886c0-24dc-441e-84a6-d951c87fdb91 3c1408e2-c7d2-4b81-a410-3f54a0758ab5 3c14ef34-0150-43b2-82c3-1ac094ecfec3 3c561334-d49d-11e4-b974-916e214c0fb73cca9412-679f-4d88-847c-27d95e60dbfd 3cd9dc35-1d71-4646-904e-e90f20e82cb3 3d0d72ac-d49a-11e4-b68f-ef6291977611 3d29f162-ff91-11e4-941e-bb6c6a8d9b83 3d52f17e-52ec-4f9f-adf7-80bc5c4f9cdd 3d92b40e-dd45-11e4-9303-a2f8c154ba06 3db3d88b-e7a1-4024-a8a1-07e26d3d68f3 3db4a51a-ef24-410a-814f-8def2a081b3a 3dca882c-442c-4553-bd85-beb470f6bfc5 3df6d1f5-0f57-499b-8914-153e1ec52b0a 3e13c328-07db-4425-ab51-d662fc96e8a1 3e563cec-ffed-11e4-8b0e-d798ef2c20a9 3e91ef09-3157-4a0e-aeb9-f2c9e14ca0f53eec6dce-dd39-11e4-aeeb-85c0c254ba06 3efe62ae-179f-4e33-953f-45fd104a1caf 3f002856-dd38-11e4-951f-29b2c254ba06 3f5db931-1844-42e6-ab69-54f851b34693 3f729ee4-e1fd-11e4-b471-b620e270cec9 3f761da6-f76e-4c38-ad9a-2bd36ea80f43 3f7d15d0-8f6f-416e-9635-6eb70613dc6d 3f955a76-ffa1-11e4-87b5-f3cb6acbe9c9 3fb46808-53da-4e8b-a669-40b8d28ee829 3fec6659-f43a-46bd-8496-abf23f082676 401697b6-1e3d-44ef-b57c-e0ced8cbbb9c 4046c73b-aded-474e-8e1a-8d66b1f66638 40a709bd-0217-46c4-9232-7e57918d894b410fd6eb-58df-4a96-a9f5-01cfc907b482 411ecf58-e205-11e4-a907-0e5d7b9b801b 413ef306-dd31-11e4-82cf-a488c254ba06 41b8eda8-d4af-11e4-ae54-f464b56c5756 41cb26bc-b3cd-4dd5-9d26-fcfcc9d4da53 41effb80-4dc0-4ef1-9926-42ee73b14c92 41f331b7-7730-4b05-adae-73271dbbd343 421b3afa-bb59-4d53-9f3e-a47f5d04878b 42c020aa-93fc-433f-bcae-9b0eeca7d49f 432c0e30-7fa0-4458-9782-9c589144193b 438df2b8-d4aa-11e4-8394-afc905c62369 43aeb752-ff6e-11e4-9a40-b43817f0b6b7 4445b933-3797-428a-b46e-780db2fc3a87446f44f9-f00f-4a79-96c4-23ebc2734165 4476cc1e-0019-11e5-9c3a-ed8682029cf3 44c2ea72-ff74-11e4-8551-d11fd903747e 44cfcac9-5e1d-4915-b055-94d55caf3739 44da2a42-431c-40a1-a198-3f602844e4f9 4513e406-1e5b-4f14-b0f9-3da10ab7de6a 4587d43a-ff7f-11e4-86e3-f8fe7fd3e8b0 4588e050-e15f-476f-9065-ba747bdd3736 458e2918-9108-4bc6-9912-edc9f5fe6474 460192e8-d4e1-4ff8-8ed1-7f16a94ab8f4 463c0a44-ff94-11e4-82de-e679d2479e07 4642e246-ff72-11e4-a380-b41eb4391a12 4650d652-ff5f-11e4-8618-ad05ebf5f6d7467d3e52-5aa3-4f42-9ec3-d1e377d75a6c 468e55bb-0991-4175-9070-a8c22aa03f18 477027ec-7d7e-43e5-9a7a-dbf80830a787 4773f884-ff50-11e4-9cd0-881b3a80df1a 47f36832-d3d3-4aa1-be69-dfea27808e6b 480ae108-dd37-11e4-8061-88a4c254ba06 483545da-ff63-11e4-8874-b22d6b99561e 4852b54a-0033-11e5-a217-b2493c85e4b9 488551fa-dd3b-11e4-92d0-56e5c254ba06 489cb6b2-001b-11e5-881e-9f76370d9ae3 48f838d8-d4bb-11e4-8756-b9b726541123 492080a3-5f90-4f63-b474-c3596dbd4aed 495ad335-b150-43d8-a9fd-fbca498174c4495afb3e-8f30-4cc5-b197-1300493fc25f 49ac526e-ff68-11e4-a906-a16cb1dd72ef 49b0f752-e1e4-11e4-b2f5-340f8fec17f3 49c284c6-ff36-11e4-819d-fbf267deea22 49d1b763-4879-4bbf-8e11-acadf272fa98 49dcf9dd-a058-47de-bf9e-9e90f4cff877 4a03e408-ebdc-404e-acfd-08a3d1b1b62e 4a552035-da30-4f3a-9df5-7e9fac8b2249 4a863729-23fd-4d2f-9ff5-e28b43c67de9 4ab74f72-d4e0-4954-b88d-e65f995085c2 4ade6634-a4b4-4f1e-9c87-ffe21b944433 4af3cb68-086c-48fd-b57b-a32a996cc660 4afb7dd2-d837-4ee8-b05a-2f5c5608a71c4b94670d-9ff0-41f4-a964-422e9c006a3f 4bd00de6-5bf3-4e93-afc2-c8203b03f31a 4bee71f6-858a-4fa4-a31a-29641a4d5c80 4c3c342f-01a5-4863-ac55-9f55cab5c976 4c8722fe-fb5b-11e4-b10a-91ba6b2ea44b 4cd07b7a-ffe3-11e4-ab40-adc3aab99f34 4cdce9f8-d231-11e4-af3c-2199fb958afb 4cdfda3a-cec1-4df5-8cfe-97e5fd54f46b 4cedad6e-ff37-11e4-931e-f89f13dc18ee 4cf1f35a-dd32-11e4-ba86-a69fc254ba06 4cf2b5e4-f0c1-4b3b-a9d5-95039175da9f 4d01af78-b0a8-4059-a7c5-b004e314e7ed 4d2ce345-8d8f-4b50-83eb-688e17b6d0b44d326fbf-594a-4c14-be82-33d495b4c5e7 4d54f302-3b92-434c-8ff2-dde1ead2d089 4d5d77b4-f1a5-4f4e-8689-033bab3ccd17 4db876af-f81d-48b9-be7a-0b8a15e10b8f 4dd18422-e203-11e4-93ca-dd97a5ed4642 4ded2760-fb5b-11e4-9dc2-c83c7001ec92 4ded87aa-fb5b-11e4-b0f7-a2b9148dd3a6 4dfd2e72-d490-11e4-ac9d-e4bdfa9109bc 4e0b1e20-e1eb-11e4-a704-aeef82ebcdd5 4e278bd5-b7eb-4bdd-9e5c-4a38896affca 4e2c843d-cc14-416d-9e01-ea37af9cfaed 4e6b1c0c-e205-11e4-a3ce-8d2a9f91f09a 4ec78760-67f6-4bca-aa62-0635e295b1f64ef154c8-d235-11e4-bc85-28a4fb958afb 4f099f85-ec2e-4a28-b230-0d5117022a99 4f0a344e-fb5b-11e4-8474-a61761501b77 4f0a979a-fb5b-11e4-b990-f7b4a05f9583 4f0ad03e-fb5b-11e4-af3b-85aa7fcad2ea 4f2ea678-dd36-11e4-9275-1f96c254ba06 4f6891dc-3b2b-453f-9173-cfcfb79cee6d 4f808a4f-ac7e-41ed-825c-0ce01d9ffc86 4f86b36c-dd3c-11e4-903e-879fc254ba06 4fc9fc70-ff84-11e4-a448-b41bbdb55745 4ff55762-fb5b-11e4-a5c2-ed83005d4feb 4ff8005c-fb5b-11e4-82e9-d41addd22315 4ff837c0-fb5b-11e4-a549-cba8babf6599500831f0-ab5f-4a7f-b2ce-02ffae25afc7 5021ca61-27bb-49b3-8a65-d3d19ebb8ebd 50462681-d1c3-4ff0-b2fe-fe2f875edf43 505df79e-d32c-4871-86fb-02b7a827732f 507e4994-ffc2-11e4-b2d4-b30b1e6e346a 50b56f7a-ff52-11e4-9c9f-c705c6c51e5e 50d80904-fb5b-11e4-8f69-d9015caa04a2 50d873da-fb5b-11e4-9663-dd4af9fd68e8 50d8abe8-fb5b-11e4-8777-dd2858463e5c 50dfe76e-f6dd-11e4-bb4b-d09bfb958afb 50ebfebe-399f-4d75-ac54-a061d69251a7 50ec023b-df42-4f83-8bde-d5fd4eea233d 50ecb5e8-7866-44ec-9bbb-5d60be340c3650f83aa6-d4cf-11e4-ad0e-fb213293cdec 511fb1e4-e1fe-11e4-8a70-730a9f91f09a 5157d01a-ffa9-11e4-9d75-c1ef76b27c4f 515f6412-5df6-469b-a149-66dd5bf2e5fd 51646a30-dd23-11e4-99bf-1e4972a8e264 5175aa00-22e4-4a8d-bd3f-80b750fbff32 51871b9c-cedb-4ef5-943e-123d1dc76d4c 518e6cba-ffd6-11e4-975c-b2ec8216ded3 51ada860-cf98-478d-a2e2-9d8bb8feeedc 51b89e92-fb5b-11e4-8e96-835dadffbde3 51bc52da-fb5b-11e4-83e3-81a8ec139d1a 51bc8a16-fb5b-11e4-a940-c8deed394099 51d7541f-785e-46fe-bd0e-c36155ee4a0551d7aa0e-d49a-11e4-9348-87c8d816dc64 51db3fbd-5ced-4577-ac69-adbd79da93b8 5212f748-e1ca-11e4-8823-95977beeaedb 5235e920-ff51-11e4-8442-a3c126b453f9 52490894-ff87-11e4-be69-be221bfd8d13 52918733-0b2d-462b-8784-70bd148d9ffe 529a9ed2-fb5b-11e4-a2ad-bded8a1cdbb1 529ca75e-fb5b-11e4-95a2-bd89a38ed7de 529cde90-fb5b-11e4-9445-ab343b516e58 52ab981c-774b-4aa3-9bec-a2a9da22550f 530eda1e-2be9-401d-87f4-cd32116c5d04 53282de2-ff11-11e4-be42-dec7e0cc0285 53a1de0e-fff1-11e4-83c8-99094acbf10d53aa9b59-66e4-433d-8405-87432424b560 53b288ad-acc5-4cbc-9b95-f48aee2a1c99 53d81e42-430b-480f-a5a5-591e1e0c2d4c 54165170-ff89-11e4-b1bb-a0a4981a71b8 542588ee-d22e-11e4-8ae5-6590fb958afb 542bb197-8807-4a2b-ba5e-0e82b1850737 542faa68-e1f6-11e4-8341-933c1d39b151 5450eefe-dd31-11e4-a095-c18ac254ba06 5460c186-d49d-11e4-bc22-e470f6d3338e 547ba46a-d044-465c-a988-55844b6447c3 54afb129-9216-4db0-9283-f64b8c6d0820 54bfd1d8-ff7e-11e4-94dd-8f6d24860eec 54d208d4-fb5b-11e4-a815-8209de18e89154d26d1a-fb5b-11e4-9f00-b9e4f28d2964 54d683c1-25e6-46fb-b9b4-fbb910b09018 5510c3dc-ff69-11e4-9acd-9c3e51a72755 553bdd1c-e1da-11e4-bd0a-facc190a8610 55751426-ad73-46b3-b5a0-c1102c312433 55909fb4-ff9e-11e4-afd3-9c6cddfbf094 559a5a3c-fb5b-11e4-b283-caf5a6099c56 559abad6-fb5b-11e4-860c-e24bf3107562 55b056f3-5e60-46a5-8721-3dd89d1318f1 55ca1dda-d49b-11e4-ba86-e8c46bcba2ff 562f0f76-0810-4598-ab80-085a84fcca25 562f245c-ff41-11e4-bb53-b25af0e7a49c 5630a954-d489-11e4-b3ee-e558599cd8855632c242-5ad0-4d74-b59f-89662c12b724 566bafa9-cd0f-4b48-b54a-1d02d8717aae 566bb906-fb5b-11e4-a711-a0dc9a636de5 566c1b44-fb5b-11e4-b75c-9d396c2072ef 566c526c-fb5b-11e4-ba9b-87edb34acaaf 56a71a08-5461-4b48-9754-8b5401925d60 57220e72-fb5b-11e4-84d5-f6a6c978d135 57227236-fb5b-11e4-bd0e-f231077ec0e9 5722a99a-fb5b-11e4-a2b7-b4f07609f992 57805ef4-dd34-11e4-992a-c779c254ba06 57e00fd4-5a1a-49d9-a190-8825b5c006f6 57e0c3ee-fb5b-11e4-b211-b3225c94b476 57e1294c-fb5b-11e4-a0e9-e6457ca5981057e161dc-fb5b-11e4-bbe7-ee3698777743 57e19990-fb5b-11e4-a54a-cb2ddb59a069 57f3f0ef-4563-4a0e-af1d-642248572dbf 584f96c7-1be9-41c1-8334-0b7ee0705e32 58625357-a105-4552-a484-b43b379b5561 58abc65c-fb5b-11e4-8fc8-d11f2c39f3e6 58ac2ca0-fb5b-11e4-af1c-be0456d28857 58ac6454-fb5b-11e4-ac36-cf832c70af2e 58edace3-27b2-4f42-8e86-c6c1030aaf6d 58f32c34-1979-4c3a-a3ee-ffbbc3c4ed8f 5925cbda-e1db-11e4-9d34-e4a8cdbd61e0 592e5f7d-5933-4aab-9f00-4be24884d2b5 59440790-e202-11e4-a267-a64f7b9b801b5946cd1d-d499-4e27-9296-b4bd97be6a69 594b5788-932d-4f9d-9faf-2cf1e6834dc6 59624b28-a3d4-40d5-b75a-cd0c4bc2d45f 5977685c-fb5b-11e4-b183-a5a24e769f26 5977cb44-fb5b-11e4-aa66-899fa83dfdf3 59780384-fb5b-11e4-809a-e8410bcc4463 5981b4f2-385c-47d9-8549-e4551c786c07 59931f65-ec17-4e0c-8d67-58a44f81c83b 5993b5cc-19d4-43a9-afb3-d3c485c636fa 59b757a4-ff71-11e4-aee6-f6bd9ed10916 5a33e64e-fb5b-11e4-90ea-9dc39ce04c47 5a343a0e-fb5b-11e4-92ef-fe8b35483d7e 5a347302-fb5b-11e4-9376-9b5ffc92ed385a34abd8-fb5b-11e4-bf15-b8dd288336a8 5a36feb0-fb5b-11e4-81e4-cbeccd1f8a88 5a372c2d-ce65-47c3-9bdc-54d2dbbf7213 5a7bbe26-e1e1-11e4-b8a3-bf31ceffdcaa 5a9a3e9c-93ae-48df-95af-9b46329e5245 5aef5cda-fb5b-11e4-a2ba-cc0292c72a0c 5aefac58-fb5b-11e4-83fa-8c4957176ce3 5aefe52e-fb5b-11e4-bd2c-bc8ddf948ba0 5af02584-fb5b-11e4-af9a-99b7704bd4b9 5af68b5a-4616-491a-8207-4bde5917e22f 5b13beae-ff7f-11e4-8fc5-b21f83f0518a 5b46d4df-046f-493e-a33d-30a40c02c21f 5b5287e3-66b2-4698-ba17-3b3d088dc0cc5b7fd013-0fbc-4e0b-94b7-b8f366153f51 5b8f183c-d4c4-11e4-8c12-868cd462027c 5ba62e56-fb5b-11e4-8b62-9da473c07521 5ba690ee-fb5b-11e4-a32b-dbb7c2c24438 5ba6cc4e-fb5b-11e4-96b2-e40f1cde5d84 5ba7057e-fb5b-11e4-a6dc-afa2d6de6c2b 5bf28ada-ff93-11e4-927c-f12e7c56027c 5bfd8fa5-9d6b-42e7-976c-39f9802a7ffb 5c149622-df1c-427d-9bf0-fef9a4631b2f 5c2ab9dd-c1ed-4d57-b68d-56a7b52b80e0 5c5fd36e-55b1-41da-9924-fb0c3915580a 5c778b04-dd3d-11e4-9aa6-fd29c254ba06 5c7f4f24-fb5b-11e4-ab1c-ffa8643aff825c7f9e0c-fb5b-11e4-84ec-992124b8f478 5c7fd5ca-fb5b-11e4-82af-8acb526583dc 5c800e5a-fb5b-11e4-bf5d-ec9bd7460482 5c8c0766-ffaa-11e4-a975-d58c79f5054e 5ca1a1e9-e308-4d90-ad82-a9adce2c1dde 5cbe9ee6-e1e2-11e4-816f-daa877a4beb5 5cf34af7-61ff-46a2-b8b3-dbd93c1093bd 5d1c54f6-d4a3-11e4-8951-dc3ad412181d 5d268178-b1a6-4a70-ad04-0168a1d46206 5d2f5ac0-e1ef-11e4-b763-dc903c08e733 5d575802-d570-460f-8fba-34f4ebeaa9e9 5d790820-fb5b-11e4-8747-b8f6985710ba 5d795708-fb5b-11e4-aae4-ff92f58f9bc15d799150-fb5b-11e4-8c01-f9d651a0a8ef 5d8ae9ba-d490-11e4-8652-87f994983622 5dae34da-0049-11e5-a2ff-fa814fa0e9f5 5dbb52e4-ff65-11e4-a3e2-92176a3baf03 5dc18278-81ec-4c00-928f-f704eff9d4cd 5e41da7a-628c-4291-b4b4-6e36205ebeaa 5ea63f7e-fb5b-11e4-bb7d-9111af9b90a2 5ea68d58-fb5b-11e4-abab-fda6038b0a97 5ea6c6f6-fb5b-11e4-92f1-998f6efd282c 5ea6ff72-fb5b-11e4-be4c-c005f1a1747a 5ead5d30-fb31-42a5-8bbe-d3c82c753a3f 5ec27c56-ff94-11e4-bf4b-c9ce1bd0a398 5f005937-1865-41ef-84d2-31d93238e5c55f26a8a9-f678-4a00-ab2e-55127476c538 5f395ea3-59c6-4ca2-8378-4320e08695bf 5f66b9a6-e1f3-11e4-8f30-aabb917fcde1 60a9ce85-58a6-4a3a-a34e-5be41e6c1b9e 60f27d4e-d494-11e4-8948-f70fcc17f74e 60fc2539-920e-40b1-a728-afac289cbd24 612b83c2-ff9c-11e4-a514-e03bd7223bb7 61508802-f7ea-11e4-af6f-80bcfb958afb 61580f5a-5938-437d-910b-04541720bc31 61d384a2-0581-4c92-9598-d77357b4a705 62259e37-f0bc-439c-bf78-9a9c51a3c862 62387764-0fa0-4a0b-81a7-2bd039a8127a 6288d3ad-ec6c-494f-a217-a61262c4a20f629a75f9-da53-4f17-ad4a-14e60939016c 62c38edc-ffc9-11e4-9c1a-da7828c58191 630f803c-e1e0-11e4-9442-5a4978cf9794 632e0900-ff34-11e4-987a-b76e8d18bc68 63326dc4-305f-4fc1-b54c-1ad38a9aad40 6379ec28-62e1-494c-9eee-a8dc7dc27c46 638d9fd0-d4b1-11e4-9a6c-edb477c7811c 63a26562-e1fb-11e4-9899-a52c75ff8f68 63ae1b78-e205-11e4-8137-1f2a42ec2769 63fd5f88-e1f8-11e4-98f2-eee85c4ea9de 644057c5-71a6-4257-80f5-320d28a21a02 648e6653-d3ea-4b9a-a32c-219e2927af4c 64dd91aa-ffaa-11e4-9a8a-f1447fb26d5b65346a2a-0018-11e5-87ee-cda64d6f6802 65c3aa90-ff51-11e4-a249-9b6e4be268c1 65e2deab-5ba3-4d8c-83a9-69b29e0e8e40 66528474-e203-11e4-b971-5a229f91f09a 6656e08c-ff4f-11e4-9f3a-874bb5f14c68 6664e287-c7a6-417d-85d5-4893dcb1ec2b 66b0260b-f242-4eea-9c9f-a96e1ec7f0f9 66c59bdb-823a-4258-9615-b9b98974bce5 671c086a-15f4-4140-ba5f-009d53265918 672047d2-dd31-11e4-a528-528cc254ba06 674a5111-7fda-49be-939a-5474ab57c18a 6788e0ea-d4d9-11e4-b422-fe500187fcc0 6843b0fc-000b-11e5-9078-f9cae4c44d7f68881e3a-d4d8-11e4-88fe-b06254ac6ee8 688c57a3-8e76-420a-8057-5d8137fff0c9 68a0aeca-6541-40cb-8777-159658573e65 68c963c0-e204-11e4-8166-9f064b963160 68cded24-926d-4f75-ae0c-021d9cf6b4b5 693b96fa-603f-4337-af8e-f037f5fab277 695a84b2-dd37-11e4-bb2a-2aa6c254ba06 6976fc40-d220-11e4-b89e-e3a8fb958afb 69785852-ff83-11e4-8aba-edf528b3b818 69846147-1ea6-47f5-b687-60d985b9362f 698ae9d2-e1dc-11e4-9449-13f0ff23e656 69d384b2-a8f1-4fca-aa65-4b16a50fe067 69ebce6d-4208-4fb2-9623-cd4b261b83676a04bb75-f54b-47f0-bc41-79d6d101baed 6a09899e-dd32-11e4-b507-70a1c254ba06 6a10023e-ff87-11e4-ba7e-9c913126832e 6a20384c-29a0-4e96-abc2-34499bb9d730 6a53fa35-9c73-49ba-8632-ce3ae6726e3f 6a60625e-3816-41c5-ab06-429625a99107 6a87ed37-6e36-4078-9018-989b138428e6 6ae4177e-e1f3-11e4-8fb5-aeea506b50da 6af29958-001a-11e5-be40-f4887f50cb0e 6b12c068-d21e-11e4-88e7-a5a3fb958afb 6b3a7754-e1f8-11e4-894c-e7baa5fb34d4 6b3c58af-b27f-45e7-9097-3a004ee9a0be 6b3cae8e-ffa8-11e4-9b8e-eaa5c124aaea6b3d0323-a036-48ea-9f54-3c769709567b 6b67bcd4-6fc6-454b-b355-3d54fcc710c0 6b919539-a157-4026-9bc3-f294b9028b2e 6bb1790f-9139-4617-8315-fefdf57de8d1 6bb72160-39ad-48c8-874b-3ca0628f926c 6bd7b6ea-001b-11e5-b2db-e9d26052d037 6c467b65-497f-4902-b40f-68a24b8c66d4 6c4e45ae-f86d-11e4-97ca-a376fb958afb 6cdf5446-f456-426f-b8da-234aaa0dc911 6cec45a1-75b2-4c78-a860-e292f80a4903 6cfff93c-e1e5-11e4-8a20-a8649d73416a 6d095c54-8a67-41c0-b909-c79a372f9f89 6dcc3f7e-f27e-43eb-bdd1-3ec57ba060626dcda4f1-0910-4e80-80b1-4357c55519e8 6e013367-6a7f-4cdd-91af-02c28c1a3fd9 6e1f3a28-9630-4588-8b0a-0404dff9f063 6e256778-f8a3-11e4-9e2c-ff5dfb958afb 6e261d64-c20a-4d81-a37e-43338123ef8c 6e3fa164-4b31-4e55-80c8-7f6c3cf81c2e 6e4e3a7a-ffb7-11e4-ab30-da2827f6e5f1 6e6ea900-ff93-11e4-919f-d4955f9f3ff1 6e93323c-ff6d-11e4-a8d1-90aa10a616a5 6f777846-9da3-4986-8e69-91874dd719ab 6f84c065-8d12-44f2-9cae-2f3b9304c072 6f90aed8-e1e2-11e4-bd4d-9866f5a66231 6fa50314-f4cf-4545-916b-452170ea47e96fa6fa69-1f95-428a-9a82-56a7f532318b 6fabb434-c4c2-40df-abdb-3b06ba2b1d24 6fcb4f4e-1a5a-4b98-a733-dcab89c06eee 6feed742-ff92-11e4-aefc-dce3f9f338a9 7018f900-a49e-44cb-8112-8ab79fcf5907 70574b64-ffca-11e4-907f-f3aec56f8c1c 709a03bc-d222-11e4-945c-b0b7fb958afb 70a798e9-fbc9-4a0d-bce8-76d72e55c372 70b7fd5c-d48b-11e4-8f01-a4957e9b6c76 70bced00-b059-4b26-a09d-02712fdc4372 70cb7dea-3b32-43ed-8b20-f990dc8689e0 70e5d8d2-dd3f-11e4-a5a5-3a48c254ba06 7101f5f7-214e-4f1a-9da9-6501ea043403713244f7-527f-489b-a6b3-d051cc240069 713b042a-000c-11e5-a719-a9dab4ee1284 7148eabc-9882-485b-a84b-2168da4ed63a 71879e78-d4da-11e4-a7a0-a7b30dcbef67 71a46c8c-e1d8-11e4-973d-81945acaaf21 71b69cc6-ec99-49a1-9dc5-55c9ba18c52e 71b99130-7da0-43cf-90ba-89eedf574afe 71ea6d6b-f6a5-4b0a-8ee1-32e61e8fc247 71f2f62c-ff33-11e4-975e-d7b51c4a09c6 72237615-1ebe-455d-a6a7-f91a4da50733 72620215-610c-430a-9271-cf7c27ec6902 72798dea-e1d8-11e4-84cd-dbc2ff23e656 72976d8e-d4df-11e4-b216-a9b957e53799729f8db0-ff60-11e4-8900-ce2035420f86 731b9b23-2e8f-40dc-9eed-c02af4c8be2b 738e83f6-5fb9-4ef4-b46e-118438f22d24 7395bc91-f2f8-41aa-ac7c-35d3c40d56ba 73a6e816-39ea-4425-a07d-e4cd531ee254 73a72f88-e1d8-11e4-b1c9-cee6231dd87b 73b41e1e-56ed-47e4-8bf3-077be227480d 73b94a33-7e05-428b-a853-5afca3d50d78 73c9b83e-d236-11e4-99fe-82a6fb958afb 73cdc20e-c7a3-4ce4-a9d6-642ae6d57e9d 740b4bcc-8ecf-442b-89f0-1dee1ce42b5a 74150044-f7e5-11e4-81b4-99aefb958afb 746700e2-02b3-45d8-8bb4-0de6d21558ad746d64ca-e1ef-11e4-bd4e-64931a8ef4d2 74925915-0801-448a-abb3-7ccc8e8ab278 749ae979-65d7-41af-9f43-5e31520de5f4 74ddc787-5fe4-4245-8d58-5d0804e3a207 74fa82ea-e1d8-11e4-9107-ae120fba82fa 7539d2b0-ebe2-47c8-ba59-4d19bd6cd6f5 7542468a-e1ff-11e4-a2fa-e71ea66539a8 754a7393-1087-4861-af7e-449ba054ce24 75afbf2e-d4be-11e4-a25e-91077d25b0bf 7615cef8-9f41-49ac-8a67-e3ddd0fef72d 764a33dc-dd34-11e4-8a0c-117cc254ba06 76773f60-1e96-489b-ad14-f74e240fbcf4 76775244-8b7e-4ad8-b02a-831d24df2928767f598d-2884-44d4-a05b-6f6fdb071966 76a8c4d2-0026-11e5-816f-b918bfbb7bfc 76b9b320-f504-4db6-9ddd-cd84b26a2212 76d6e27b-7069-49d8-990a-ef4a282a2efb 76f072ca-001f-11e5-86b0-fa0b05d0458c 77093f40-e1e7-11e4-b253-8b65557324be 77203c42-dd44-11e4-bfb1-1da7c254ba06 77585726-de1d-4430-97a4-f5020e6cdc80 775a7e2f-791b-4d8f-9af6-a9018b78b2a6 77759ac1-2574-472f-93fd-cdddb0ec6a00 7832eb9b-0cc6-4210-b027-767be307c098 78359d0d-32d4-4df8-bef1-667127e96519 787decca-f86e-11e4-8be4-037efb958afb78fdcfe1-4c58-434b-8c04-3e66c42d288d 79309235-c27b-4be9-b06c-d17b0852317c 7982cfe9-e0dc-4f14-b25a-4406b8d564b6 79d0418c-c744-49ec-b375-4baf9ca23783 79ebb7e7-ea2c-4a9b-840c-77a5e754b26c 7a160935-af2a-42d1-9029-55c43a1a99b7 7a33e1b4-8b2b-48f4-9503-c4731b727b85 7a4e5dca-e1d8-11e4-9920-e1476179f732 7aac4b08-2122-49da-a472-5186d38c2c3e 7aca28e1-5580-401c-a29d-b52448b0a9f0 7b4ad790-dd45-11e4-a8fb-4404c254ba06 7b58175d-68f3-4e46-b70e-b580319dd13c 7b5bbc92-1a3c-4660-9d24-1d996a7b50d37be2d6a8-f889-11e4-ba8a-987afb958afb 7c14fa65-4e1a-40e7-b865-28af3912136b 7c156208-4f3e-4b6b-9b3f-a6b6b670f3b1 7c1e249a-e201-11e4-8f79-57f74a963160 7c2e0376-dd31-11e4-b027-b78fc254ba06 7c3c688c-ff85-11e4-bca6-e685e13f4dd3 7c880f42-0036-11e5-bc3f-8674e2367bbc 7cf51d86-ff45-11e4-8442-92a0cb28dcbb 7d199b76-dd39-11e4-abc6-dec3c254ba06 7d540b63-055c-4cf3-9249-c44de8f90e52 7dca6ebc-753a-4560-ab06-8c0a7ddda302 7e412b3a-ff3b-11e4-b606-8491e77431c6 7e42640a-f88d-11e4-b2df-e68cfb958afb7e4da3ac-ff44-11e4-8b46-aed672b919db 7e8fa344-dd32-11e4-adae-ffa2c254ba06 7ec790db-ba31-4736-8cd5-8f82736e3e76 7ec9e97b-8bef-4fb0-8639-cec88e770dbd 7eec1989-1959-40fb-83a0-16dfd5ac3787 7f192200-ff73-11e4-93c7-a139ed5f4bf3 7f1db529-612b-49cd-8e19-4141dfc3ee80 7f24d120-6f66-4588-9894-63f882932991 7f2ac906-afe8-4106-bc6a-528e50aea7ee 7f87dfa4-e1f7-11e4-bf19-e4f4a6653850 7fe438b7-31a9-4b85-b761-f3bdf1467355 808e9937-6986-41b4-8406-74701267514d 809b40d0-7933-4313-8b07-c3fafefe021380be99d4-d488-11e4-b678-89eb00ee7f05 80c22758-ff48-11e4-85d9-96c6b7910b50 80d288db-0a7b-4e2e-a89a-570a470feaf9 81506fe0-357a-45ca-8112-cfdb9d2bf809 81929ba6-a393-4090-b480-d1e6ce1d1e59 81e70640-0000-11e5-85cb-aab287fe0753 820f2112-dd3b-11e4-8b45-55fcc154ba06 8255895e-f893-11e4-98ba-22a3fb958afb 82612382-dd35-11e4-9923-5b8ac254ba06 826d37cd-4da7-4edd-a317-4b8779a9005a 827dc390-f886-11e4-9a26-776ffb958afb 828680ae-e1ff-11e4-9f14-7d2d0fba82fa 82ce984e-ae61-40f4-8af1-51f197e01e6883344129-5606-43bc-b2af-a879d7a2024c 833cdc6c-dd38-11e4-8ffa-a3b5c254ba06 834340c3-2681-46e6-adec-157827cc01d8 8367aa8a-2fec-4139-8d23-a90c939a82d1 83ce25be-ff34-11e4-aab4-cfaf3dbcf8d8 83d821c6-4d55-4631-ba2d-84c149e9fc22 841529b1-23bf-4adf-918a-021e8c1876a9 84363a27-1ccf-4a3d-b75e-7f3de47512c6 846de7bc-d495-11e4-b6d8-d2d321f25276 849be998-e1e5-11e4-ae5e-dccda47388b2 84ef891c-e087-4b60-83b9-ab1858b0564c 8504c84e-21f9-469a-84df-1c8f77f668a9 852bfc08-ffcd-11e4-8c37-d48af9c286008537c37f-39b7-4c1a-8cb7-a3cd6817b55b 858d0e9a-b806-4e85-9902-27e5c23c6bd1 85a1c9fe-0eae-4303-b9af-408d92100518 85c51332-2b9f-4b14-920b-071179588696 85cb2484-f88b-11e4-bec1-8787fb958afb 86049b82-f891-11e4-9d55-fa9bfb958afb 8617cb2b-cb3c-49b9-9b63-b885a03e4637 8631d5c8-dd36-11e4-b9d1-4999c254ba06 864c2793-408d-46ed-989d-3e8dc19bef78 8669b05c-ff86-11e4-9197-a714b77063ba 866d65b8-ff3f-11e4-b413-bdbd66be296d 87250fa0-d22c-11e4-8449-3b8cfb958afb 873d786a-d4de-11e4-adcf-a5e03234076387729268-fb5b-11e4-aaa7-98d3ab49cf80 8778ddbc-fb5b-11e4-9936-9651c024abc2 877d516e-b9ee-4056-8e7b-feafaca0341d 877dfd24-fb5b-11e4-8b00-bef0183d4e4b 877fec2e-fb5b-11e4-b813-b7592c1975ef 8790fd54-ffbe-11e4-ad77-93021ae2ab64 87b0e8ab-a88f-440d-a067-ba4eefc8becd 87cee72c-ff9b-11e4-bd92-8f516c0b364d 87ecdcb5-8ffa-4c6f-81cc-0520b773585a 87edf660-ff43-11e4-ad93-b52d974d72d0 88003006-e200-11e4-af7b-62234fb570f9 884c67aa-8321-4b6f-8d03-465c2dedb220 88693172-fb5b-11e4-898a-f079212c4d17886c03b6-fb5b-11e4-9832-b0f479db87a1 88787748-e203-11e4-a9f9-c7557b9b801b 889fb8e0-a0a3-4471-b3f1-95a935c66f5e 88a468dc-d4b9-11e4-8bdf-b6f92d1b34ca 88b75299-d9b6-449a-82cf-16503985d10a 88c30b9d-b302-4422-8df8-9c1a64d7181c 88c66027-f9bb-43f3-af2a-37acff4c3c03 88d78a48-ffe1-11e4-a36c-cc98804f2b93 88dc0fb8-ff10-11e4-8621-dabc1b054f03 8942f1d2-fb5b-11e4-9a8c-8b92431d0c96 894353a2-fb5b-11e4-86af-a9a1c3943636 89469602-fb5b-11e4-b994-b334811fe7f6 8946ccf8-fb5b-11e4-b4b8-ed0bb6ea79d189528d96-f7ae-11e4-b904-98453e4822e0 895b0102-d4b2-11e4-b0c0-b6139891c95e 89b3791f-f1f8-456d-bc3e-f96d3967e1a1 89ec7e72-a295-4b12-a438-574da1038ee8 89fc75f1-e78f-46e8-a6ec-618f142d7470 8a231888-e1f8-11e4-b5aa-391f6eeb50a1 8ad6024e-f6e4-11e4-9d8a-81b4fb958afb 8ae54c88-fb5b-11e4-9e29-f751c9097c58 8ae5acb4-fb5b-11e4-8d1c-ff230491e7ae 8b41c749-efc4-4586-b909-c843422d0354 8b608b7a-d4d5-11e4-a827-bd90bc314f72 8b7748c4-e1f5-11e4-bdc1-fb4b7d696080 8b802643-65df-4585-88f8-5790ea0e06398baa7d18-0007-11e5-b512-b21eabc85cb8 8bb00a9a-fb5b-11e4-af12-dea3b8c2cdbc 8bb06bca-fb5b-11e4-ba6e-b8b71a36f54e 8bb0a31a-fb5b-11e4-9e25-bb614cd8a70f 8bb0dac4-fb5b-11e4-a1a1-9daa56a42fd9 8be311f0-354b-4fdf-bb58-e787c1f09466 8c1fb552-dd3d-11e4-bf8a-302dc254ba06 8c71dfd0-fb5b-11e4-a2ae-ec9a36a0fb62 8c7242ae-fb5b-11e4-8c73-ded20e6bd078 8c727a30-fb5b-11e4-b0c4-d7b1d037764b 8c7e71e6-377e-4192-80fd-9b1ecce38739 8c812695-1f57-4b08-9139-cca5c5e0c918 8c9d65a2-dd32-11e4-b8fb-c1b4c254ba068cc7ffde-fffa-11e4-8447-8dcf254bcf62 8cd050b3-eea3-4188-96f2-a5e5c94ccfae 8cd2af98-e1f9-11e4-b7eb-e4c182ebcdd5 8d2fa8ee-fb5b-11e4-a06e-b26325ec8633 8d300a0a-fb5b-11e4-8095-bb00b380b912 8d3041fa-fb5b-11e4-80ef-ffd3cb1cadb8 8d93a3f2-ffc1-11e4-a2be-e8f35e483f92 8d95c3d0-ff71-11e4-8291-d3006535c872 8deec45e-fb5b-11e4-8a4a-d5c78b3ee49d 8df032bc-fb5b-11e4-8593-c1138df45219 8df0694e-fb5b-11e4-bcef-d92597b33e07 8e3302f3-db79-4923-992e-c72af448c0a9 8e3c0a5a-692d-4e52-863c-ab2a043483ad8e84934b-2a78-437a-8e38-03121475c0e2 8ea1f8e5-4fc1-4cab-8f99-26039bc52a8a 8ea79830-fb5b-11e4-a955-8c8788c32fce 8ea7e826-fb5b-11e4-95d5-cf5523f773b7 8ea822b4-fb5b-11e4-8685-acc4d4a15ee2 8ea85aae-fb5b-11e4-8aa5-89cf300015cc 8ebd29b8-06ae-451a-a5e3-6a764c9e55f4 8ef4db37-221f-480c-aa8c-dbb284a4d6a1 8f099e82-9243-4801-8978-48b0a65f29a6 8f0ea36d-10e7-43bd-9083-ab7aade0c28c 8f15f278-e204-11e4-9ddf-b545b13b0664 8f589de2-fb5b-11e4-a607-88d4adeb436d 8f58ebd0-fb5b-11e4-a1ec-91a1e5aa3c168f59235c-fb5b-11e4-b901-afecc151914a 8f595c6e-fb5b-11e4-a50d-a9e6e01bc447 8f915894-a329-48fc-a64b-695e462a3793 8fa217f1-88a8-4219-9c67-c839d57f6888 8fa99755-1143-478a-8dc0-883e0edc2bbd 9019bafe-fb5b-11e4-a174-beff442feb3b 901a0860-fb5b-11e4-9264-9c2aab20ae82 901d74a0-fb5b-11e4-9da2-848acf174487 901dae16-fb5b-11e4-8a8e-9cc2610a964b 901de55c-fb5b-11e4-9875-af2cc3faae89 9021118c-fb5b-11e4-adde-bcec17da5ed8 90e09a70-fb5b-11e4-b37f-ac169538f775 90e0e822-fb5b-11e4-babb-f5facf4ef33090e1201c-fb5b-11e4-8b7c-8c4efbd701f8 90e1573a-fb5b-11e4-8f8d-958245a8bd07 90e18f84-fb5b-11e4-9732-e738b53be48a 90e1c634-fb5b-11e4-a557-fdc8e5c14de1 90e1fbf4-2d7e-4c87-a9a9-2b69da8a5ff5 9104f3e0-dd31-11e4-bec9-d293c254ba06 912357d6-7316-467e-bfe2-48224b58e579 91a8b848-fb5b-11e4-864a-c77dd2ed2b6e 91acf7b4-fb5b-11e4-8ebe-a192737ce377 91ad31d4-fb5b-11e4-89f9-8e13c55667d3 91ad6b9a-fb5b-11e4-8854-e3f0cbdd42eb 91ada574-fb5b-11e4-9a0b-cbc67628add8 91add231-aab4-474c-89d6-7047ba3682a591addd32-fb5b-11e4-8365-d50bb1acad32 91ae1612-fb5b-11e4-b9ec-dcb70a1f69f2 91ae510e-fb5b-11e4-b479-ebb180523eb3 91ae8868-fb5b-11e4-aa4d-d245cf1246b9 91aebf4a-fb5b-11e4-932d-a26546131f9d 91ce15f2-ff3e-11e4-9d73-85b485b025f8 91dda774-ffd4-11e4-ade0-fe3f54dde56b 92142364-e1f5-11e4-9e4b-f7c9c579ed44 9276dc64-fb5b-11e4-8e86-9883cbecb019 9277291c-fb5b-11e4-b55f-945f6284ce04 9277624c-fb5b-11e4-befd-a356902b4d37 92779adc-fb5b-11e4-ab81-ab73ea6c8516 9291fb76-e606-4750-b6da-300108cbacc792b90324-e1dd-11e4-a340-e2d4cdffdcaa 92db42e8-ff4e-11e4-8f64-a628a9c4e9f5 93019f02-e201-11e4-bdc6-a50f8d07f9f4 9318445a-e1de-11e4-836a-e42b9d73416a 9341c290-4634-4bdc-add6-4617cc5132b3 934eb3b4-fb5b-11e4-9183-9d32fec754a8 934f0030-fb5b-11e4-8240-9cdc180c36ae 934f382a-fb5b-11e4-a495-8683a3f6a45e 9351ff10-fb5b-11e4-ae19-bc29db4f4ebf 9352366a-fb5b-11e4-bab8-8e4c97968a24 93526eb4-fb5b-11e4-b8e9-f13b3ac7c669 93787ee8-976e-45ff-a9a7-16560d53eac1 938e4e94-9cfd-43a0-8413-ebde19c7389b939d751e-ff3c-11e4-b21c-8503e52f3747 93c71fdd-bf93-4c80-ae86-a822f0b6c441 94d23f5a-e1e6-11e4-968c-df4bceffdcaa 94d74357-dbd9-4ec0-90fb-01e398134570 95077ffa-0025-11e5-bfd4-b602b14b3fa8 95094841-10b8-4ef5-94f9-63118d94efc7 9554cb36-850b-481f-8f3f-94b2f68a424d 955fee25-8fa0-4871-90c6-6e4c16f421e4 9570574e-ff91-11e4-b8c8-a2d7d0a7af3d 959d6cd8-9fae-4c40-9488-ef94bc23e95b 95b6edd2-fedb-11e4-a5d7-b4c15a84bc4a 95c3f3f7-6789-4b31-b162-30b9a5973030 95d7ed06-ab94-4920-b447-100335a5491d95dd4887-4d06-477f-8092-9a5267c1158c 960e8ba5-fad0-48c2-89e1-f8c20159f90f 9731abd8-ff4f-11e4-9834-c409300180ae 9732ce6c-ff79-11e4-99e1-b4061a8854d2 973858ec-000e-11e5-bd9f-9bfda751b980 97b49088-ff64-11e4-9142-c24a4ec0008e 981ef671-f809-4a0f-9835-fd982eec007e 982660a8-e1fc-11e4-ad44-73f0cdbd61e0 98b19090-3f23-4aaf-b4d1-7de701d2efa4 98f2d5fa-7957-4a71-bb46-728ff20776ae 992f1d95-109c-4783-9392-c7587a539e8e 9944f4c6-59ee-4b65-a129-30b06ae4b07d 99697721-c39e-4043-a42c-865d3df26da1998977f2-d480-11e4-addc-f952187d5a80 998b7240-d4e0-11e4-8488-dbf49687fb63 99a1ae9f-ad61-4808-ab86-89730a6d77b1 9a169b61-e1e1-40cc-960b-d36cfee74246 9aa59d4f-9787-4046-90ec-ea5cf870ddc5 9aec9782-e1fa-11e4-af01-35e7cdbd61e0 9af7bac9-d150-4c4d-bec6-22418c49b39a 9b2aa87e-71f7-4d07-a6da-c744670719ba 9b2c17dc-ff63-11e4-a751-cf661f00d34d 9b8a5dac-fff8-11e4-bdd4-e6d9aed69e99 9b9e9b38-847d-4fee-9d65-78c3aa0a93d4 9bd34f64-f7ea-11e4-a6d5-43bdfb958afb 9c1382d9-91b8-49f0-adb5-0fe490adcdd49c2529b2-d364-455e-9702-f89ad879f055 9c296a8c-78bc-4b72-a372-1d6f6daf0702 9c5c8310-d4a4-11e4-8050-843db4250de8 9c6244f0-e1f4-11e4-8872-ca469d73416a 9c8edb4c-ff85-11e4-b3bf-96c604cc7358 9cad5f4d-1643-4c4d-968e-2a4d7641b7c5 9cb13393-46c8-4f4e-8a82-f791ca3eeb15 9d04b618-710c-474f-bede-348b27e3368d 9d5dfd9b-2725-4153-9de4-a274d3306493 9d620846-ff03-11e4-9fb2-8cd2ad6cf358 9d64fe50-c860-4a40-baac-d3ba2073e742 9d926891-cfc1-4ecc-b6a0-1d98bb49f9e1 9da91059-89ed-406f-b11b-e67a113e87bc9dde4aae-ffdb-11e4-9f46-bc5161ecb24f 9e1819d4-ff66-11e4-bb91-c6242bf2649b 9e2c0efe-ff6f-11e4-af88-b67656fe781d 9e6e8eb4-dd3c-11e4-b28a-39d4c254ba06 9ee80518-0c9f-4d2e-acd0-70253ecc8fa1 9f120f02-24c3-4344-b5f1-02e63e9eb0cb 9f1876a1-8d9c-4a1e-9de6-68afba5232fa 9f3a1794-d4e2-11e4-b511-d1951205d4d1 9f4175d3-6a53-4d12-a360-24f4e0bb5681 9f667d6e-ff6e-11e4-a418-af128d255f37 9fab2abe-ff36-11e4-8875-c62865bda9bf 9fe898c6-e926-4ffe-8b87-2c14d8d57fb3 a017bf94-ff45-11e4-9356-85bc73bbd8c6a0384d54-dd3f-11e4-8ac1-584bc254ba06 a0725b6a-a045-42b6-b8d3-ef340941b8ad a08814fc-dd34-11e4-a193-4b7ec254ba06 a0be369d-8631-4658-bdf9-d0cb0a386228 a124ec1c-637e-4a02-b16b-3121f6ba573c a1a63456-218e-40be-aeff-c6e5565f8cbf a1b115e8-ff50-11e4-afc5-e429b50d9f24 a1b62118-e200-11e4-9986-923aa20fa9bf a1d922bb-a14c-48e5-86df-c6e74413955e a1eed29e-d6f3-4a9d-a31f-83997b237d05 a20ea0c2-f8a3-11e4-a163-915efb958afb a23f8ede-e201-11e4-a29d-f2ecce2f5b95 a27a550e-d226-11e4-acb2-6a6dfb958afba28417d7-5915-4fd9-8c1d-3decff6f02aa a288ca34-1390-4217-844d-568b70e1f763 a31adc16-ff78-11e4-9ebe-d783a04f19ae a3d9a13c-dd36-11e4-b04f-109bc254ba06 a40fd4d4-dd39-11e4-b774-e8c5c254ba06 a459804a-0046-11e5-94f0-d88f5473802a a45a0f5c-b7db-4149-9c47-c86bf6f472fb a4a0928c-dd32-11e4-80fe-13dac254ba06 a4ba0c52-371f-4049-ab36-76b830d0249a a4c92b8a-f41b-411a-80a0-1fa6da81d221 a5358064-dd31-11e4-a980-6996c254ba06 a53ab4e7-ce07-49d9-8758-327f517a7c97 a54376a4-feee-11e4-a2c2-a013b0e7fe91a547b3d2-d233-11e4-a9cb-809ffb958afb a57ea7f8-ff37-11e4-bfa6-a44871409f5d a582d927-9110-4c8d-929a-bb99b5fcdc72 a5cf5506-d221-11e4-8475-47acfb958afb a624f550-ff90-11e4-beb1-c17d3c36051f a64a4582-d22a-11e4-8b5e-4985fb958afb a6802114-001c-11e5-b2e6-989351ccbc43 a6903506-ff3e-11e4-a356-fad5cb01de01 a6904a39-5605-41cc-a0cc-12cb45fc9a25 a6c6d888-d22d-11e4-84e1-738efb958afb a794392b-e8c9-4cee-b7fa-aec3b96f6c55 a79f2580-ffc8-11e4-9aa3-9d145c1677c3 a7ef9068-e1f7-11e4-9973-9028ceffdcaaa83e65c5-f98d-484c-b14f-c4b8bfa962ac a83f389c-e1fd-11e4-beea-0adb190a8610 a85abe50-4a7b-4c06-a593-ae4264d93bc0 a878d276-e486-4b84-a18b-b52f1f5ee89f a898d270-ff95-11e4-93ed-d341b7a4bdf4 a8e54068-ae42-471b-aefc-7a6a1e515bcb a8f5a65a-0047-11e5-9a97-a837b4d683b2 a90594ae-ffd7-11e4-b751-f9c181ae1ef8 a9ed40c2-d4cd-11e4-8938-9f40591ac8b1 a9fde415-1397-4a49-9c8b-e7fed32bf9c1 aa0dda2f-4ee9-487a-ae31-cc6d1eb4adf8 aa3607ba-1e1e-4099-8197-da680e69925f aa3a6d6a-d497-11e4-b2e3-f6456ba5fc1daa4a1492-e1fb-11e4-92bb-bdc50b709990 aa90a676-6268-40c6-a126-d073fa2f88ee aae1d6e5-d41d-4ce3-9def-35c37601cf61 aaff09c1-7c1f-4421-af06-694d615ac72f ab13f512-24e0-48ca-bd35-792cf5d0e34a ab2c6d3c-851e-4adb-8cd0-a17fdd8b9a7e ab5951a5-3906-42af-b873-72b9949cd1fd ab6f71e5-233f-40ff-926a-e5d34b8c4324 abdf3e82-b138-4465-bed1-d4e5f68e8f7e abe86d64-dd44-11e4-a915-77f9c154ba06 acb2c3f9-da15-4926-849b-a32a4f1a83f5 ad4c031c-2b9a-4bf9-9447-81f4f29d3f92 ad77a215-4537-444b-9f36-73426f9f45f7ad98d0aa-f8a5-11e4-81fd-3265fb958afb ade3be6e-b09f-48cb-a0e0-9fe791932b63 ae0b1f6e-3c64-4f3c-a09b-cce58c463006 ae1cb1f0-8341-45fe-95e0-0a1af80c869c aee67c66-0055-11e5-8e35-ccca80e7376e aeeec974-d482-11e4-8ba3-dd46c2cd3bf0 af164f07-db8a-4566-a4fa-641a69911f9d af31b27c-fef1-11e4-b1af-e17eb5105e18 af34668c-d4d7-11e4-8770-81ed70ad3328 af44c950-24cd-4767-b646-a678c50690e2 af610ae6-f6da-11e4-959e-a492fb958afb af75668b-22d4-4660-9044-9197b07893db afcc03ae-e1ff-11e4-b000-e30042ec2769afff2215-f3ed-48a3-9719-fc8e7f1fe6f5 b007ae52-24d8-48ca-bd6b-1d1c1d3f22e1 b023c10d-de06-4186-8dce-8da3894ccdca b027be94-d48d-11e4-b702-96be58fe76c5 b03e6e9d-1451-4718-91fd-452009bbecd9 b03f5400-0034-11e5-9233-8890b2c94c67 b04474b0-f893-11e4-b474-d9a3fb958afb b078e34a-d4a2-11e4-b290-b314fd7f2830 b08ab03c-d21f-11e4-8624-41a6fb958afb b0dac201-9d2e-4ed8-861c-a37540e39611 b0f67163-9244-4a7f-860d-bcfd1292d665 b0f7b8b5-e313-4476-b2f9-44fcaf9c2fb2 b10a88d5-3469-4e19-956a-09d83e04149db1c3906e-dd3b-11e4-ab75-128ac254ba06 b2099fea-ff33-11e4-a355-e0bb5acf3348 b22c5a18-f6e0-11e4-8ef4-b5a7fb958afb b2356f78-e1f9-11e4-8e21-fe92a20fa9bf b25bc77d-cf07-4421-ab44-95e03b7fb71d b25f37c8-e202-11e4-956c-d3130ae66825 b261570b-d4df-4b22-901f-83daeef46563 b28997c9-fa4c-4290-981f-57c593706d5a b297d0e2-da01-4ef1-b7a8-2d19a0ff7d8c b2afa56a-6c9f-4aad-9280-8cd04aeea306 b2b09fa4-8bc6-4adc-a489-6b8c870da67b b2f5a279-accc-4241-968e-476465ee3156 b329e58a-d48e-11e4-bfb2-a6d39e4a37b9b3aa1d2c-6052-4733-b8bf-8992c27d97f1 b3b1cf46-e1f3-11e4-80eb-a0501b5396e4 b3c836f9-f04f-4403-827c-908f60d56cb4 b3e63ab6-760c-4e1b-9f14-71b31e73530c b3f61371-2bdb-4a6d-a19b-228317e7c5ab b3fff32c-f6d6-11e4-ae7e-d184fb958afb b40097e1-9713-4466-a09f-1a2b5e7962d2 b42bc079-4b18-48cb-87b5-f212e65d0758 b4831fc0-fab1-11e4-ad02-8cb311ea3bc0 b4836eee-fab1-11e4-b4eb-925c08f086e2 b4839b12-fab1-11e4-8b25-ede1a58e0f46 b483cbe6-fab1-11e4-a06a-e0824ce86dc7 b4b337ae-4156-4638-bffc-2864cecf0e15b4da5d29-b297-4f3b-b22e-0dcdc7a4071a b507dbd0-ffe2-11e4-a660-9ebae48396e3 b51b53fe-4bc7-426a-8ae8-66f40b0c0ee6 b51c550d-d83e-4170-8834-8cadc913c8d2 b521a4de-e1f1-11e4-8986-fa48ef7160eb b54dd3aa-2b15-436e-8bb6-65ab65ea7608 b55cc258-5264-43dd-b42e-6f1f81bcd0c0 b5700204-e49b-4c3d-8318-a4b694480fee b57a4c8e-e1fa-11e4-aaae-cb07e270cec9 b5a7f10e-d4ce-11e4-b0f3-998103221222 b5ce745f-ca69-4c5d-b5e5-29471efd7c42 b5e929b9-86eb-4b3e-a34e-72736d9db059 b65afdc7-50e1-4c1e-a792-bb887fb2bdb0b667a400-dd38-11e4-b441-e4b8c254ba06 b6a428c2-f867-11e4-bbb2-c84cfb958afb b6c3105f-77c6-4894-8743-9f76ea72d9ff b7021d28-750f-49cf-a536-85b6775a52bd b70f1298-ff67-11e4-8be2-aefd7e00b322 b73485ac-dd41-11e4-a1fc-2053c254ba06 b739fca4-dd36-11e4-bdd3-639cc254ba06 b7618c9c-f875-11e4-93a3-c7a2fb958afb b7a709a7-edd3-484f-bdd3-60c0f0c06e48 b7a94678-4f13-468e-ab4a-a702b8b05f67 b7ac3072-96a1-4652-b694-ca5de7710941 b7bacade-ef74-49eb-9cdd-f1ba42342dc8 b7cbf312-ffa9-11e4-9368-c9f435ea1ab0b7dd85b0-dd43-11e4-b5dc-6576c254ba06 b894b506-fab1-11e4-878a-88808a7665cf b895166f-c785-48ec-89dc-a795d9bea4f0 b89520a4-fab1-11e4-9e00-f8a0192c0c51 b89549e4-fab1-11e4-9683-b8afcae5894c b8957284-fab1-11e4-9b58-8e35faec91df b8f20f62-c93a-4992-9355-aa84c68bbc65 b90b842e-e1cf-11e4-8fc1-46b37beeaedb b91e66df-724a-43b5-85da-e1003d07d4c2 b94165c4-ffe0-11e4-b7b2-dcb8d09afa03 b94d618e-3204-4831-8fef-c68fa6e938a2 b94fb095-079f-4fe8-acca-182342aab1d2 b9570238-8066-4991-b1a3-097d199b3af0b95a05cd-5293-48ff-ad5b-12c1120d719b b9753306-fab1-11e4-b7f9-a0c75eb125de b9757384-fab1-11e4-ab1d-eca5830d5667 b9759bf2-fab1-11e4-a3cf-8b5e07801653 b975c514-fab1-11e4-82af-b1774dc87afa b9d4f1b4-e1fd-11e4-bb07-c6d5917fcde1 b9ff0522-e3ff-49c3-857d-d571e62b6b3e ba2dd3ae-ff5f-11e4-8c2b-cd66b3c4f69f ba32f95c-e1db-11e4-a846-36800fba82fa ba92c434-3604-4b85-bc76-3bbe5c44253f ba93a1dc-d234-11e4-abd3-8fa2fb958afb babeb7c0-ffdc-11e4-afdb-d1dfe5a88878 bac0571b-023f-46a7-b83a-08d38216480fbb6ac238-d230-11e4-b140-6c97fb958afb bb8cd408-ee39-4dc4-8657-0c53ae5ee47c bbffe3a8-d4b1-11e4-b624-ccf7083e925a bc039118-d4b8-11e4-a147-84b03d54f755 bc045814-ff65-11e4-a9e7-f202afb9ebe1 bcbd4dfa-7758-4cf2-b3a0-7d36f1e01853 bccdad3f-64ff-4dff-8259-2db9bacff4ff bce5aef4-ff3d-11e4-9a80-a2d08ffb807a bd43b518-d480-11e4-9cef-8ad127de0353 bd88b235-e203-4510-a264-e1df0a076c0b bddb49d8-dd35-11e4-8a0b-c68dc254ba06 bdf4455b-15ed-4a37-8250-3bd80a4ec66a be7df1d5-0202-4661-a1fc-f77c10ed4952be7e0d7d-142e-4bf4-97b3-c9cc7c763687 be7f9265-cfba-41ac-b0aa-81d9806b72c5 bec08a02-dd30-11e4-911e-ff7fc254ba06 beffd9ff-ca40-43dc-b428-f67a18fb1373 bf42c272-e200-11e4-8928-d42e03b1cd43 bf622082-b075-4456-a7d8-8d35c3cf42b7 bf82eecc-e1f3-11e4-9e70-3371782a667f bfa05012-ff4d-11e4-a466-df8a2cd3bf77 bfd4ba58-7a29-42fe-bbd2-6ebf90bd5347 bfe1a38a-f4a3-49c7-b425-faefe7e2c23e bfef03c1-8e21-451d-a67f-939971915c6f c0216334-bffb-4218-acc4-e90e24cb56a8 c037ab74-bddf-49ea-b178-7649a24804cac05a2114-d486-11e4-a205-c0246cc6aa08 c0655f95-468f-4e63-bfad-2c0e97f7dc72 c0a8e0de-ffaf-11e4-a727-fafb1c4112eb c0c0d3b6-dd30-11e4-9c60-4680c254ba06 c0c41532-f895-11e4-9ccf-17adfb958afb c0e4c222-e1ee-11e4-afbf-9ba2930ea054 c169529e-e202-11e4-8b08-e7b75418f422 c1af7691-34f6-4318-a959-5ab48442e60f c1b62455-a8d3-4d19-8786-6582f54b0775 c23adfd0-ff80-11e4-9c80-a4d9a5df0797 c26ce1a2-fab1-11e4-b3f2-8425840e922e c26d2414-fab1-11e4-bd3b-8080761e0552 c26d4bba-fab1-11e4-bdb6-d498fe8d510dc26d750e-fab1-11e4-a6b7-dab7a0151996 c2a3e22a-e9cc-447a-b419-8667cce10da1 c2b4405e-e1f9-11e4-a0f7-837f4fb570f9 c2bd300f-81b6-4847-aee8-f5a1e45f165d c2bdb628-fabf-11e4-94c5-b573582bd6b0 c2bfe3f8-fabf-11e4-beba-f6f5a0af86dc c2c00f90-fabf-11e4-931b-cef8f4a63852 c2c037fe-fabf-11e4-827f-d1b9924239a1 c2c98782-fabf-11e4-89b4-a8895988c3ec c2cbdca9-aa60-42b6-bacf-2a75edc63a23 c2d1d68a-fabf-11e4-96d6-f087d1bc89e5 c34b3ff7-f3f4-4081-98d4-4db202e34014 c375eebe-fabf-11e4-a64c-fef676995018c377842c-ffa1-11e4-acf7-9f46f57c5783 c3844876-dd30-11e4-9ea1-9b80c254ba06 c386e2fa-fabf-11e4-b4cc-eafa7c381edc c3ac56f2-ffce-11e4-b536-d1f840a98a6b c42a0582-ff35-11e4-bd4e-b25715d5c9d1 c43d39b0-fabf-11e4-9ace-b427666c2535 c440d92a-fab1-11e4-a42e-9b05e2d2a3d7 c4413136-fab1-11e4-8bd6-a617794b136e c44159e0-fab1-11e4-8344-801c9e9461f0 c4418208-fab1-11e4-afed-cf67edc8d667 c441ab16-fab1-11e4-91e0-b33c8a128cde c4484405-89b9-4321-8403-5d4775589c5e c4485020-fabf-11e4-a23b-e0f4229f117cc4487c94-fabf-11e4-ae05-c86081f84244 c448a66a-fabf-11e4-9448-e1ffa22114db c455af86-fabf-11e4-9e88-c6be32964a48 c4561098-fabf-11e4-9709-df57984bddb5 c462f158-d4ba-11e4-85ac-bedbc4ac5db3 c4960f4a-e1f1-11e4-8331-b8a01a8ef4d2 c4afb504-d63a-494d-873a-6a7d30091f2e c4b16a2d-f51f-4dbe-b6fa-28f57b454d93 c4fce566-ffb6-11e4-a9d7-ed068d55b99b c506be62-bdef-4365-ac72-8263bdc230be c50a23a9-32d6-4aef-99e9-9b6d08fbbe41 c5b68258-dd44-11e4-b71d-a98ac254ba06 c5b91222-d4dc-11e4-a54f-80c93b5367bcc636e062-fab1-11e4-8462-edcd347250e6 c6372072-fab1-11e4-8535-d831b72a3458 c6377144-fab1-11e4-a4e8-d1a225848e93 c6379ade-fab1-11e4-8eb6-801254eaa565 c64ada54-542d-445a-8827-7a60f46b5b7f c6893214-d224-11e4-85d0-cb56fb958afb c69cd1a6-518a-4eda-a936-223fceeb4525 c6e6819a-e2b3-4401-8af8-e36ae207050b c6ee426a-874c-48fe-9dc0-d5a2cf4fa7ba c6f32c4a-fab1-11e4-970d-f263751e532d c6f36cd2-fab1-11e4-a5a3-b10fc3213e90 c6f39644-fab1-11e4-82c4-aa44edf36b34 c6f3bf84-fab1-11e4-ba6a-ac63204db8d2c6f65c79-8d8b-4784-be80-64a69b4cc000 c6f9960e-3b93-4ced-bace-d24c08f4429a c6ffa07d-51bf-44c9-a4ae-6366bb45d0be c7042168-e1e7-11e4-bcfd-837772d2bdba c70dbecc-001d-11e5-8574-b56ec7e024b8 c70f52e2-dd30-11e4-a68c-ed80c254ba06 c718dfe0-be49-411e-a4d7-c7cc3f063177 c730bc78-d481-11e4-b636-a27a25f02b4e c74ab71a-657d-4344-9d69-62b73334ed16 c785320c-4dcf-48d3-8908-133bcf3dec12 c7b1653a-487c-435a-a308-174bce76b71c c7b4c13e-fab1-11e4-959e-c5766c123fcb c7b52e58-fab1-11e4-9182-c53d6d25328cc7b55964-fab1-11e4-839c-e93bb9858105 c7b583da-fab1-11e4-91bc-d84a7dcfedaf c7c70aca-370d-44ed-9610-3641b76fa5c2 c7cb56e5-d6f1-44fa-9d16-adbeaebf5647 c7f0800c-b685-4861-a785-988e1994f117 c81dee78-d484-11e4-89b6-d8b07afda675 c822e89d-f2ff-4e44-a42c-ab9b062839a5 c8414c0f-425a-45c6-acb4-d532cc651398 c8434128-e1e0-11e4-983c-9e47f69e2eee c84850c4-ffbc-11e4-a798-f8b7d693ea1f c872adb6-fab1-11e4-9b1a-dfaa81250fc0 c872eda8-fab1-11e4-b67f-d70d5eccbbc6 c87316a2-fab1-11e4-a7cc-b5ff6a99c4a8c8733f7e-fab1-11e4-bb33-bd3a9b716377 c8a84054-d6cd-45ba-be19-06a8179afda4 c8dd67cb-c930-4614-8843-8da6374ac0eb c92c82df-7583-42f7-b4f5-da7581a43e7d c95a3f38-9d0b-4590-b08d-90d2f383c7e5 c95bc731-e496-415a-871e-95308b9a73a3 c95fcb60-e1fb-11e4-bf2e-c43c7b9b801b c970169c-e1f5-11e4-9f94-19694fb570f9 c9b0be7d-280e-4c01-b676-2157cc3273bd c9b15851-96f6-4c0f-99c1-d781c19fe87d ca730d24-e1f0-11e4-9ba5-cf3a6bc51c8e ca746884-dd33-11e4-a1bd-c01bc254ba06 ca9e54fe-9b22-4d88-83f4-0af418874545cab857ea-fedc-11e4-b415-866eef321591 cae03431-3985-403e-ab72-e8cd232bea88 cb106196-ffb9-11e4-a365-9c0c028631c7 cb505ec8-40fe-4d68-8b71-1a07c0ff9d0e cb5e49c3-bc74-49c5-8367-862a77ea1299 cb778ce8-d21b-11e4-943c-9c9cfb958afb cb9a424b-022c-490a-a7df-9baebe213262 cba7f034-6498-43cc-a261-7040de9a85ef cbc087d6-0033-11e5-ba9b-d41dce0f5f2e cbd0d578-ff7f-11e4-a2e2-a227a478affd cc51e6b6-dd30-11e4-a12d-8581c254ba06 cc58b6ee-d227-11e4-9567-027bfb958afb cc8787bc-000d-11e5-9f35-eff86d5cd0cdcc985b9c-d4c9-11e4-a242-9d1647f6be82 ccb8999d-ebc9-4bb9-9b51-991f12857e62 ccbfddea-ff7e-11e4-9150-d0143e3a46a8 ccfb8f5e-ff6d-11e4-86b0-991bd067c170 cd7b3747-0703-455f-9cb6-b02b9bf8ab00 cd834f22-ff84-11e4-b762-8ce8315be4fb cd9a3f72-dd36-11e4-b689-a79dc254ba06 cdb198fe-d4c9-11e4-904d-b61559633223 cdb5fc10-a798-48e4-b2e5-8a562bf30f63 cdf2e7d1-c09f-404b-9669-9c165efa0a66 ce2b27ab-3ea1-4e32-b3e5-f64d4666baf1 ce3d8f3e-ffb8-11e4-a34c-d80a76e97ab4 ce6a5156-fab1-11e4-8470-a5d834dd29abce6a7fc8-d4c3-11e4-83c9-e46b9a21e50d ce6abc22-fab1-11e4-99fb-ba4554f0e9ca ce6ae4b8-fab1-11e4-bb05-840294058bf3 ce6b0dda-fab1-11e4-8c89-d026f2aab407 cee641c4-e203-11e4-8911-b22042ec2769 cefaed3e-d4e0-11e4-a77b-a7fbdfb461e2 cf1524e0-e1fd-11e4-9d17-f6e54a963160 cf297906-ff51-11e4-aa6f-a3eabf498d36 cf2b5069-eedf-406e-a1e8-474afbd5b340 cf4a7b25-42a8-4e95-a1af-f9736e7a87e5 cf5358b4-d492-11e4-b5f0-d24a48487c91 cf9a7ca0-ffd3-11e4-89b6-c639b2374f27 cfcd7bb7-a9dd-4279-bce7-ef9cb4f8173ad00a086e-e204-11e4-9cf5-bd50a20fa9bf d0b700c6-ff7f-11e4-b0d9-d00eeabd5949 d0dc8664-dd3f-11e4-8ac1-fc4dc254ba06 d0e5bdc0-f887-11e4-a9de-4b74fb958afb d0e6ec46-3ba5-4af6-8cde-542b5ad79913 d0e776fa-c6ca-4c90-86d0-74289b200c17 d12dc51a-a781-40e5-a232-aea9df3b033e d14cf198-62fd-4787-9641-0b77d0c1ea99 d161720c-ff72-11e4-ac10-86f461e9b2c2 d197fbba-d4d9-11e4-896a-b2a35f256d1d d1b07588-e1df-11e4-8ca8-6896a20fa9bf d1b1e8b0-d225-11e4-94ac-2c5afb958afb d1c96690-e1fa-11e4-b2d8-8f534b963160d1cb812a-ff3f-11e4-8794-c200aeed6634 d1d1b24c-6f9f-4602-b109-35a6d811a33a d1eb36a8-f60a-4301-bc66-23661f6c9c63 d2673f0a-c3cc-48c8-b083-faae43b7bee1 d2736990-001a-11e5-82b2-82628c354281 d2f55e4f-d495-49ce-b6ff-79ffa03f0ba6 d31c60d8-a513-485d-bcf7-9fe814780f35 d35e1f73-b215-4a57-aa2e-463124cd5d61 d39af404-ff94-11e4-be2d-b8f8e064d857 d39b828a-e1f2-11e4-a076-f731782a667f d3af5e60-871d-4838-9df4-0498c32fd5c0 d3ce9704-26d6-4ed2-be67-cf91b1387a36 d3cefab2-aa60-4103-9ea8-f0cfe58829aed3eb985e-dd30-11e4-9b44-3182c254ba06 d4194596-e24f-11e4-954d-5d324fb570f9 d43ed88c-dd41-11e4-9fc0-ad43c254ba06 d4592468-44cc-4a8c-857b-12aef379caff d45dd806-ff4f-11e4-b0a1-c9629db17202 d49318d3-3fa5-48ae-8598-6da93ffa8caa d55649ed-2634-47d9-8480-51ef964a5743 d59606de-39e0-4117-88ee-049d5c6b012e d5a2b174-0002-11e5-b6bb-d7ac5479037c d5e5ef29-b60d-462e-becc-bd905d250163 d61a0a9b-e554-4a52-bc2f-a0674cd44a77 d6255598-ff71-11e4-9dc6-c6ef9959bf8b d6395021-f46b-411d-8091-7ae761f5e191d64cc332-8aef-4172-9e7a-bd544d721b72 d6ac2a74-d4a5-11e4-9f55-8b9019a4f637 d6b66442-ffa9-11e4-95a4-b7c7d1c0c501 d6ee7330-3522-4d1f-b493-d36b50fb5f95 d70c8044-0683-4cea-ab50-d81743a814d8 d724c7c4-6f6b-4998-9e1f-03884ea9b59f d78dcf10-d29e-4585-8845-aef27f3ba149 d7b5452c-e1d4-11e4-980d-85ae8eec17f3 d7f647c6-dd3c-11e4-b839-fc21c254ba06 d805f85f-6142-40df-8280-9fc07ddc8cb5 d80af706-7971-472a-85b2-77d481116de9 d8124e5e-6b08-408f-bc62-b2a62752212e d84262d0-f873-11e4-a3e4-549afb958afbd843674a-ff83-11e4-a358-e615a37d34c6 d8543de2-670b-4e2b-9881-dc5ce07893f5 d86d4503-a3bf-4e11-a844-6132104c61dc d89070b7-792f-4636-a8c0-b4c1bd4ff7c3 d8c8ac7a-c116-4d3b-955a-476d9c73673d d9078cba-7cef-49c4-a8a7-ad2e8b4c900e d958af14-d729-44f6-afc8-505fd67af792 d9bcb72f-4e25-418a-90a8-4efbdf63ef74 d9ef3fe4-ff86-11e4-9795-f0bd9880510b da0ded04-a867-4d48-8e16-028c2cbc2f29 da2e717a-dd38-11e4-bd8b-d8bac254ba06 da31c704-c194-4361-95cd-e0464d6ab8af da62cebb-2fb2-428e-83a6-26034b608d66da9a3522-ff34-11e4-8dea-cb5e8c3825e1 daa87a2d-d163-4542-b555-4664e8da358d dae56e0c-4471-4b1b-a0d0-44a973ce2fc5 daede27a-0025-11e5-8746-bf2976202c54 db04c588-d485-11e4-961a-9b235b693b0e db6c2e94-e1e6-11e4-aa38-81ff547324be db9a449c-dd30-11e4-9114-8082c254ba06 dbe34b62-3b12-401a-9908-7ffc7d18ab41 dc057aaa-a003-40ad-8f0c-7b069c1dcc84 dc6cfa31-4b89-4a16-b1a0-8600f7b1a79f dc9ca6fa-4560-4d5b-887f-665c4fff81aa dc9fe40e-92e5-42e6-8e44-0e090d5b8aae dcf886ec-ff94-11e4-a8aa-d3781fa20b78dd3f83b8-ff3e-11e4-81af-910d0943bdb6 dd6e3e97-7ea1-4ffe-91a2-18efb1e7899f dd8035f9-7285-41be-b5ed-3ccdc4e161ca ddb1ea28-a0b4-4c09-aa0c-41d34d042329 ddc55606-7e72-431c-b0ef-eec0b12f0caf dddb3d8d-cb40-4950-937b-3978b729f483 de11bbf7-23d0-4327-804f-0a6a31a7a225 de1805d2-fff6-41c5-a9f8-ad7a76ca3c7f de210c24-d497-11e4-8dcb-ff6452e46ffb de2bc0e8-bf7d-4196-93a1-20e1fecaf66a de2bfd3a-f609-11e4-8db2-ba96fb958afb de399eb3-5479-46e2-8e9d-cc870c4d9abd de8e0f1e-f886-11e4-93ef-a770fb958afbdea22f82-ffe1-11e4-b931-b1f2e154cfa0 deaf9fba-ff3b-11e4-9f93-c869b88a0374 ded7493e-0315-4738-8ec3-686f6880c4c0 def974bb-4832-4cb5-b63e-b97efa2fb346 df50b56a-fff1-11e4-b066-e150411119e2 df980cfc-0b67-4b07-84e4-d4d0c169f964 e0233f82-ff68-11e4-8b7d-c37169bf8a0c e067389f-df15-4adf-bb2d-4c261b9bf8fa e096370e-dd34-11e4-8386-dc81c254ba06 e16d9910-6472-4d02-be49-f42d12f91fee e1aa6445-b3fe-456f-b650-819a9f12c910 e1b05966-36f1-420c-903b-102558b97df9 e1b783b0-acd8-4531-9013-c8aa5e26f7b0e1dd4ec1-f0e4-4f3c-9877-80b724f74c7d e20ca448-f7af-11e4-a29f-978716736906 e21c1878-d235-11e4-99ef-38a5fb958afb e2842883-cb93-4366-956a-681aaa90b706 e2c08d2e-456f-4b8e-90cd-cd56b7023c0d e3181490-d229-11e4-9c78-cf81fb958afb e3209066-f86c-11e4-99c0-4473fb958afb e33149ad-7364-4f58-9d6f-22707511f4d3 e3667854-6b7c-4395-9040-65d1ba8a2e3a e39d86ee-c47b-48f1-aa49-ce8c029cd6d0 e3bf46e6-af7c-440b-9a78-7b8b960921d1 e3c76689-f9b4-43a8-a10c-33fd79a86dd5 e4049f73-e7f7-4321-9df9-b0e8dbbabe9fe4236fea-000c-11e5-80dc-854c02f029cc e423ab9a-dd39-11e4-bf6e-a5ccc254ba06 e42761d6-000d-45bb-97e6-f2b647764682 e43faa7e-dd30-11e4-ab1d-3283c254ba06 e48fb1d2-f4a7-4b3e-accd-0b53abe76be2 e4ee1936-4089-43af-a21f-e87834f631a2 e50a2ba2-1528-436f-b213-defec56f31cd e5404aea-d4c1-11e4-a259-b36fca32d320 e570a574-23ac-4c1e-8bd7-4bc463d81ab7 e628cb66-f7b3-11e4-980b-b2bf33e83580 e6528f04-b4d2-4a7f-a69c-b1e95fb94c96 e65ff82a-2049-4e64-ba45-5a3c50d89e03 e681e844-ff6b-11e4-b08d-c4e58af04be9e6834d9c-db7d-4456-b29f-0327b2e0f201 e69fb1da-4e53-40d1-86cd-9a87b56e1ec6 e6ea79c2-ff93-11e4-bf83-c076bdf06feb e7697e88-96df-4c96-ad8d-6c54df95d29b e79b1741-0b2a-4e71-8f41-1c28b8c46021 e805b7e0-ff02-11e4-8401-c4ab7bc679ec e810eeba-eca8-4792-a9d5-fbe7da7ad416 e83340a6-d1b2-4ba7-b4aa-7540bede6fbe e86f6765-2a01-46f0-9eec-2ad1d01e3455 e8cc78ec-ffbd-11e4-88fe-f2b98edfe475 e8d42f56-ff36-11e4-b202-cfb89223445a e8e2acc3-9fcf-4a28-a129-fdfcbd0f7b4e e8e3b04a-58ee-49ec-8015-4d5ed6e7bca8e8e873ac-ff7d-11e4-8329-a53de02dc714 e939802c-f86f-11e4-8afe-4f85fb958afb e947887d-2f16-4a38-813d-4fd49af1d014 e962d5e6-314c-450f-97b0-f5f25e8bcb3f e98a084a-8cf2-42dd-a4b7-40f3288261cb e9e3068c-b5c9-47cc-a0c6-1359e82cfb5a e9f2ec60-ff45-11e4-8924-f8bbfea5bf74 ea0add07-2cd7-4230-a37d-c621bec85b17 eaa42780-e1e2-11e4-bf59-d6efb5fa6e67 eaf06e02-ff91-11e4-8f89-a0d3db8ffc62 eb48b638-dd37-11e4-860a-a0adc254ba06 eb51797d-88aa-4fb6-bb7c-ff499f3189fd eb7a8840-e1e5-11e4-ba5b-fda10cf231ccebb56084-f7eb-11e4-b667-88c0fb958afb ebc85b18-c95d-41ea-a03f-da971300410c ec1b99da-6e2c-4383-b215-31a993561b33 ec1e598e-a879-4d79-b25a-3bfeab2b5c91 ec222e10-d4bb-11e4-acee-b3094a0e5e84 ec683d1e-e1ff-11e4-97f4-53129f91f09a eca5197c-d4b3-11e4-a0f2-f6a8246bb544 ecb63422-e201-11e4-8c8f-c74429975181 ecb8385e-df8c-4e76-b24e-760010fee63d ecfce526-e1fb-11e4-8af1-35879c8b0f27 ed3c53e4-e1f8-11e4-b9e0-ba484d1861aa ed670436-e1fd-11e4-b312-cf8790e4cd7a ed951674-e5be-421d-a978-df88c4e79e55ed98b8c1-f356-4e3f-a794-95cf33b89d75 ed9a6669-a4df-4d84-ac83-b8f519c3f491 edb8e13c-b10e-4a43-afd7-6c70c86b6c3f edc5da14-dd30-11e4-802c-d583c254ba06 ee00c91e-e1fc-11e4-a8fa-15059f91f09a eeba9aa8-809f-4d31-956a-b816e662d15c eeddfaa8-1a12-47a2-859a-a9d710471b64 eeff99ab-8b22-4e52-a24e-2ead9cc3cab1 ef012f9b-1026-4419-88f4-8a2e55512cf9 ef3dceba-8b56-470a-8a08-d82b4da7d5d6 ef59992f-ef6c-4873-87c7-335c13bb78ef ef6e1118-ea8d-4e2a-af93-80d4b371b182 ef81b5a4-ff62-11e4-b129-9812933aa51af00a9542-9f5b-4847-836d-bfbf60f4302e f016d676-d220-11e4-ab9a-03aafb958afb f03da5fa-9be6-4f0b-aa0b-c5f2b07a2d7e f0623896-ffd9-11e4-a812-b30e79a5014e f08c4f4d-3344-49c6-bb15-a1ce5aa3ef20 f097c5a7-85c7-4233-86c8-15cac9f2e86c f0a28b62-ffbb-11e4-91b4-93a7f5381cf5 f0fb7e76-0019-11e5-b7f6-9d7042403e11 f10e7080-dd41-11e4-ab36-e1e4c254ba06 f11b5f2a-ffc9-11e4-a8d6-d5587ec8bab3 f1592852-dd35-11e4-86fb-ab90c254ba06 f1682f50-5698-446b-a06c-faffd04d97fe f1785b27-2b42-47d5-b0f5-eb4606940e74f1792077-d481-45d7-bb9f-73718327e39a f1a011da-e1e6-11e4-9048-b03a1c44a9c8 f1b58fce-fb71-46bc-84f9-c641f4cdd2f5 f1d8a363-3071-4740-a20b-63f0729d07cd f20602c4-1b00-44bb-8c2a-c5e6f03c3b15 f237b64b-3102-4b09-85cd-cb4f025598e4 f23a5f03-df98-4979-95db-c194467266aa f2498212-f7b5-11e4-98d0-fd46f8b8021c f257160b-4b16-48c2-a1b3-50acd99d4b1d f2619bda-ff4f-11e4-ab30-eba228a41355 f26e73ea-9282-4e81-a70d-9fad49c91109 f294e77c-93d2-49e5-900a-90bb8eaec0e5 f2a5a12a-e1f1-11e4-baa7-65d68eec17f3f2b1dcd6-ffda-11e4-b0b8-c6d5ccb625dd f2be2f3f-43d5-435e-bd15-6056657c2205 f412044e-e1e8-11e4-a56c-90219d4f5ec7 f414667e-d222-11e4-b48f-5e49fb958afb f4288632-a94f-4777-a5d6-1a76b12abcc5 f43220be-dd8d-4f7b-9429-c8ba02a7f2fe f43251fa-3d28-4440-b33d-817360b11e0d f440f6a9-1db2-45fc-a0aa-7bcaff6ee0df f450ce78-ff33-11e4-b86c-99f9bf25669a f46d3c88-f895-11e4-825e-97adfb958afb f483b460-8be0-4e61-bfe2-afc041089da1 f48cd28b-368e-4de6-b051-1a48381b9866 f4e8259c-000b-11e5-a5d4-a883468762a3f516cda0-5a3c-4f17-87f0-0c2a42492037 f51ee8b7-7b99-4407-83fb-9b395ea7f31a f5410668-dd3c-11e4-a82c-0324c254ba06 f58676ca-f60b-11e4-8600-849dfb958afb f58702e4-f88a-11e4-82a9-b484fb958afb f5df74ba-0791-4982-af1c-fd4c5110f110 f5ef55ba-58ae-40cc-a645-95d66cd944c7 f63cd04d-d0f2-4988-a955-e3b95e933227 f64a7d4e-ff3f-11e4-b01e-fc79349e1f8d f66cc91a-ff9b-11e4-88da-944301bc3996 f67c6cc6-fc0f-4e9e-83e1-a299b8381f7f f6a7b6ae-698b-4a5a-b909-a9d90dc88a8a f6d1f68a-f877-11e4-b4f9-40b0fb958afbf73f3736-e201-11e4-9fcc-d11b9f91f09a f74bce5e-ff9f-11e4-b108-8a70dccd0a7e f752e5d9-00a8-41f1-ae38-2b589f499088 f7591db8-c0d1-4cac-8468-b43b994a5bf3 f769d54e-8963-410b-b7da-09ebd42a3329 f7baaf60-149c-493c-b6f9-6ffc63b9b040 f7dd5447-a028-4a58-85dd-994b75fbf7eb f7ee5fce-ff69-11e4-8ce1-da663b7d8839 f821aefd-9919-4467-9e79-0d5ca6974603 f888fc09-259f-42a1-b4fe-04403fcef6f8 f89124c7-2baf-41d9-9caf-656432dcbe88 f8cf31de-dd3b-11e4-bdf1-bebbc254ba06 f8e6851f-a0cf-4b0c-bd7f-56debb0d6605f9200bca-ff70-11e4-bca6-8ad7c5f48011 f970b300-e1f1-11e4-a3ac-b3a03c08e733 f98658a6-dd30-11e4-a293-9384c254ba06 f9b3cb64-3cbb-4aea-8d2b-fdc70aaf918d f9e89c56-ffa8-11e4-8a45-f3ed3cfd4619 fa03d4fe-477a-427e-a2dc-d7c759921be6 fa1380a6-84dc-45cd-a826-83ff7679419a fa147ede-d21c-11e4-8cdc-859ffb958afb fa2e025a-e1df-11e4-b18c-6c140fba82fa fa40fc42-d4ac-11e4-adaf-c29a4e08dca4 faa09864-ff9a-11e4-99bd-af5b95b6ee9d faa55724-f86e-11e4-a6b4-0e81fb958afb fb204dcc-dc93-44a1-b498-c8b31e2c02fbfb821758-ff40-49b5-a5b5-fbfa490e50d5 fbaff08e-7ffb-4885-8f03-5fe930826be8 fbbb57e6-e200-11e4-b1fd-fe477b9b801b fbbf36d8-f8a1-11e4-ad70-0958fb958afb fbe1fbc4-dd43-11e4-becd-a0a6c254ba06 fc09a2b9-b0da-4dc0-80c8-206f3f9441e7 fc50c8e5-af63-4e45-a158-0d7239b42102 fc67779c-210a-4f80-9184-697d5cfe1cc9 fc8d69b5-1b5a-47e9-b4e7-c0ced58673c6 fcc84258-d4d0-11e4-9d73-8dd8b349a7c4 fcded466-28aa-4f92-bbcd-6f58c6053224 fd0d3756-ff63-11e4-b7fc-a481c8e688de fd3a70f0-ff62-11e4-ad95-df92ae1525a3fdbde764-feea-11e4-af6f-8ae09f0a64fb fde64268-7ada-474e-a903-08ceaabea383 fdfe025e-f873-11e4-8424-009bfb958afb fe7cbe2d-2e22-4ca4-aa8b-e1ae81d90ffe fea0bed0-dd3a-11e4-a09d-2be1c254ba06 feae357d-f624-4ea7-bc40-f9b4a31d4c22 fed62a83-8097-438f-af48-4390a6dcc196 ff9bc3df-28f9-42bd-81c2-f69ee2da1d00 ff9be992-d4d2-11e4-b835-e1b9cc16db13 ffcdb0dc-e1eb-11e4-a3ee-884f1a8ef4d2 ffe5563c-6b36-4ad9-a61e-127b6c053727
ENSG00000000003.10:001 2787 1838 4391 2010 489 3024 130 56 907 129 280 5967 1147 4531 0 361 1203 1225 2041 463 1411 153 127 2367 1225 2681 3033 2346 4 1106 1247 0 6102 56 17 49933299 2764 1377 3200 1740 1935 7925 3993 4079 2327 1960 55 23971583 90 1203 1337 694 3640 133 1730 3508 1241 2328 5428 27 233 1293 145 102 4297 31 1988 1870 772 3113 2435 4385 41045548 503 2829 4885 171 10222 631 2501 1184 2410 1678 3903 20632194 2800 1281 431 623 1932 3784 3699 1628 1252 911 0 24821684 2404 0 2474 38 142 163 1344 955 440 1471 1474 15781512 1800 1798 1772 1721 981 999 926 989 937 897 975 964 1349 1275 1444 1360 1407 1269 1339 1367 5397 2342 0 9 3911333 72 1010 2397 545 553 553 508 536 745 1408 1446 13841778 353 171 4084 2218 2102 1521 1448 2675 2516 761 4029 12573592 1 1002 2271 2177 1445 1484 1500 1528 432 432 478 459 461 2921 1144 838 2793 2711 2771 1946 2339 191 102 795 35561441 129 872 245 118 805 809 768 787 701 520 2450 12881955 657 1244 124 698 1479 1203 1203 1143 1130 1125 1900 27791210 196 4 1216 762 359 2314 1708 1757 1768 1762 1701 1 5895 17 80 1025 964 912 949 414 201 3474 574 67 100 935 905 916 896 929 140 196 1408 2017 977 1501 99 160 59 99 1402 3470 3225 117 73 4245 1596 1896 743 1508 2089584 993 1986 2137 1753 148 85 0 1170 3657 1423 385 679 3003 0 1980 3406 88 1988 2052 178 1167 7123 799 4313 1023268 955 2203 1637 1490 2599 894 560 321 4611 119 210 16361169 3082 777 2126 1581 511 694 3441 1513 139 123 1154 0 722 976 1991 194 6243 1750 3216 4450 6081 6008 986 13349 7346526 1859 2014 3866 6727 2178 4889 594 605 580 619 1123 152 2592 869 204 1554 3310 740 128 0 2121 2217 2117 2060 43 161 2339 783 822 821 796 6630 2976 33 2876 1401 2127 22662209 2179 728 3367 9249 7568 104 2246 1779 0 1417 2872 456 430 448 458 1312 1389 1363 1363 1788 1838 1778 1844 669 755 730 726 642 646 611 642 345 717 1759 3386 185 109 12271218 1251 1238 1212 471 1732 113 405 2754 2714 2695 2794 28512018 151 36 824 1898 1960 1963 1989 885 938 999 989 13251849 1183 491 159 2427 1090 1053 1112 1082 203 223 223 217 1215 80 3984 2335 2733 4430 7221 798 3980 1082 127 138 1680648 1198 4103 805 889 3728 696 1286 1082 6229 642 5268 894 2172 1092 239 1507 3307 5844 1257 3107 0 2220 1081 351 44021313 1836 3848 882 596 96 75 4061 560 239 128 997 19023298 434 1 2917 1485 153 484 136 2299 2300 821 454 3074890 139 122 658 70 14 6659 9015 1491 113 3140 83 0 2500 1357 412 1390 1664 754 1406 479 1267 1424 1976 1969 519 174 0 1630 104 780 3116 2518 2789 6755 4 2211 784 36651267 1264 141 921 1332 4563 1489 6517 0 1131 1452 1368 13531005 6929 2283 1406 150 1111 1111 1069 675 312 2181 1119 153 387 2004 1817 1868 2 3087 1103 3691 152 4964 95 722 42161951 609 455 874 1344 1324 1328 3278 35 863 3607 76 124 2637 1715 1800 1722 451 2992 276 698 662 1871 1 495 0 5265 2392 1377 131 4092 1042 199 2355 2520 571 111 2221 2051367 1125 1177 1270 84 5623 185 149 350 758 1137 1098 11072629 924 927 950 2830 364 1114 1224 1153 1122 2547 282 21543437 3346 3339 926 1027 1214 1279 1674 1698 5030 1782 1414 14161438 4426 2757 1248 93 880 855 871 815 820 34 2104 532 768 737 761 756 2255 146 1312 2403 2126 283 1671 1714 16761674 412 1329 9453 8891 1877 914 507 497 482 484 444 18191269 2514 190 2362 762 998 518 548 528 72 112 130 24983033 717 793 833 743 6935 136 10 915 736 2903 0 65 1686 160 2 276 1776 1239 563 1047 273 148 1151 259 2888559 125 2799 2753 794 2056 1544 444 332 391 1913 1870 121 2452 2694 2119 3860 2087 1924 130 227 138 1582 10255 4769 663 10602 1983 0 130 827 1309 1094 1131 2271 1998 225 1348 114855 2360 1037 267 0 1027 7313 193 1600 5029 2141 1731 2780502 2207 0 913 1344 417 1132 5668 1318 187 1422 1 2211708 472 138 97 2015 2818 2043 4828 860 2267 783 203 1703145 0 27 95 2132 2382 1317 2215 710 879 1396 164 12021355 900 9382 221 616 1745 603 175 147 3507 2561 1023 5110425 987 5012 3 2846 1108 1 643 2242 1632 918 2758 11101525 723 1325 56 1165 1159 24 1320 1802 77 850 761 470 2655 866 2058 105 1647 1715 1154 0 1480 2851 851 1668 23712472 1183 2690 2256 1604 2186 1647 4432 0 1188 2636 2187 1397494 449 125 740 2372 1401 35 0 183 1644 5620 1 579 117 632 853 911 1988 2226 13 1640 318 76 8323 3908 1 804 709 0 1414 9 0 1108 3362 858 237 999 2928 154 2028 1070 2384 137 796 13 2754 120 2736 1952 2113 2789 4 01792 694 2313 836 53 0 126 921 873 3993 858 3053 432 2635 157 4727 186 1293 2703 2746 2897 3488 1038 2 811 15473492 119 273 770 816 805 788 73 19 1085 1651 154 107702796 2744 3450 431 1493 2232 403 2138 2143 2095 2136 2588 823 1004 1069 1080 1388 2674 1765 249 622 2592 1464 1418 1414 150 106 1698 1761 1681 1266 2149 1083 3254 2161 2143 2661 2732 21552563 817 2860 1300 3364 3407 772 776 3290 2482 2085 1285 12541279 1133 1126 1118 510 548 527 256 235 242 890 1312 26961330 1381 1360 524 515 4383 520 485 1242 1217 1243 34 124 1629 2383 2284 1440 1465 1046 1714 219 1628 3628 4348 3084 30293109 3236 3297 3380 1561 1287 150 1186 1711 4589 91 1269 67962512 123 471 87 878 1633 1015 552 120 331 344 147 11021033 2667 2328 4620 3028 18 92 119 3028 2568 1518 775 876 2561 110 716 3204 0 3314 999 6887 38 858 860 1586 33111338 2136 252 1611 409 3067 429 178 127 650 2334 711 116361 1501 133 90 6668 222 1310 22 2848 830 536 998 123 1942 12 1222 1 2234 1 1735 2058 380 585 858 407 210 1294 3069 4737 1849 4196 350 0 190 1433 0 122 3 457 217 1698 0 1296 132 1185 823 1065 2221 4303 127 1596 421 476 102 711 4154 10866 19 3913 674 698 3684 1774 4199 34231851 600 1848 9142 2538 6420 284 4210 1015 968 100 85 1808335 63 298 6 1522 384 1609 2322 526 453 4820 826 0 21 0 4531 833 5027 4387 910 232 0 968 3394 840 30143569 3949 5664 2381 2599 124 1463 441 3129 5256 2883 0 2649850 2925 857 875 864 1126 2103 184 1836 1917 183 2677 15493503 2053 89 3298 4777 160 1089 0 1065 1852 207 1560 400101953 1903 1869 1789 393 688 525 4052 530 476 537 3550 13051335 120 1002 3162 1422 2587 2939 2966 2866 2919 3272 1297 134 1969 1937 0 240 3986 2 2024 121 21 125 6923 1707 154 23 738 1773 7963 102 2822 1544 2632 1427 1547 67 544 198 1621 1065 3746 2184 533 154 28 150 2369 1 1342 2636 14191140 124 2334 2215 2327 7460 1746 891 613 1590 1763 1758 34093559 2918 3529 1675 1120 217 1677 1118 119 187 1286 936 924 923 876 946 2698 1236 1169 1448 1464 1496 89 1931 1065 1190422 1198 1667 1417 85 786 796 783 772 0 0 459 36231328 2560 2537 2475 2473 590 1012 2552 1211 502 1696 2378 86 492 2070 1105 6649 2039 1970 2021 2568 1706 1633 107 6320 2543490 172 925 995 954 3574 2440 2098 1975 1947 844 1943 14892020 2234 2382 4680 4325 76 4736 335 780 1675 0 853 1007846 135 1900 0 361 54 1169 367 72 1141 148 1468 101 1917 2081 3091 402 1329 19 1209 1237 1216 830 117 5870 374 971 1517 120 129 339 1921 377 512 0 1727 3819 837 640 433 44 5658 1 1086 61 1670 1692 12898 304 7781 1338 487686 1127 686 2234 2965 2108 1899 2680 536 126 2031 3367 1514798 1451 736 428 907 1165 85 102 1953 1800 1855 335 52441951 1911 2639 3724 1 136 1850 5854 8147 1354 1729 1770 1467410 2003 2308 2451 7398 238 2886 707 112 205 1496 1843 751 2294 414 5015 3347 133 54 3832 2587 904 0 5145 1653 2411224 1091 4 5369 0 206 50 5032 1428 246 4355 115 632 1217 4209 1906 1512 1072 1801 54 0 3513 759 0 1 893 783 1657 495 1921 2371 212 4263 2680 1483 4407 3421 2761 116 3834 110 1263 2759 467 1728 62 144 501 1776 268 3466 28462301 444 82 2393 611 180 0 1388 1814 899 322 104 35902141 127 1371 2599 2135 19 1484 1917 1839 235 2434 56 12433499 1732 1573 1330 3489 2358 2378 1865 1701 916 2684 2149 32362946 1094 1344 4332 116 5 2 2209 232 1018 278 180 273 1601 127 982 1594 2623 1811 1034 2597 1581 2339 2263 881 39 433 112 81 2782 1840 211 2365 1591 0 2159 55 1237 382647 0 835 2943 204 2673 4319 2221 0 0 2134 756 2262686 159 2660 2779 0 1753 126 3057 2746 320 20 4775 462 3252 2855 5428 1047 2620 114 537 1465 1987 174 2068 4187 0 557 95 281 1 2299 2537 3992 1416 0 1098 1045 872 18624375 154 1213 103 376 108 2137 0 715 594 4851 4304 1974305 1595 461
ENSG00000000003.10:002 953 600 1357 757 230 813 55 16 321 46 98 1792 358 1791 0 170 418 515 773 241 697 63 46 717 459 754 1107 757 0 425 442 0 2215 22 3 17941093 665 556 1126 579 705 2672 1382 1332 811 791 26 708 524 46 319 426 154 1304 43 576 1250 411 787 2054 10 87 463 66 37 1563 8 676 604 191 1110 879 1536 19181521 182 640 1718 46 3339 241 575 464 947 568 1294 657 633 790 502 231 238 556 1301 1290 650 409 346 0 996 623 818 0 1069 19 54 74 405 326 73 627 572 624 613 712 691 689 652 287 294 296 290 423 407 404 410 528 454 521 506 602 597 586 610 1978 775 0 5 1240119 34 229 657 221 212 182 191 214 209 485 470 486 608 146 76 1523 757 828 508 498 841 941 303 1759 306 1115 0 332 825 772 628 547 554 587 130 127 126 113 130 945 412 328 738 757 781 747 830 80 31 349 1145449 57 289 101 39 374 357 353 382 261 179 800 419 607 206 487 41 232 292 414 442 415 413 401 611 856 417 70 0 406 357 123 754 588 594 609 607 587 4 2069 4 35 476 466 472 435 155 69 977 187 17 36 299 300 340 328 311 62 71 356 588 137 512 45 76 24 36 430 994 1285 26 26 1460 500 649 311 485 752 47 430 652 657 626 64 29 0 313 1411 449 157 288 1141 0 406 968 47 716 653 73 254 2508 169 1469 375 97 395 606 594 431 909 327 164 120 1506 54 69 435 392 1015 303 879 529 204 276 1130 497 58 47 399 0 245 406 740 60 2258 655 1245 2015 1972 2074 301 3905 2915272 735 699 1288 2453 746 1523 300 297 288 316 363 44 682 249 100 598 1046 243 56 0 735 756 745 709 24 68 742 305 312 342 291 2591 1129 12 1128 518 888 967 920 892 222 1392 3069 2391 46 713 660 0 571 717 210 206 186 214 591 587 585 641 698 666 692 736 270 300 292 288 326 307 286 345 133 262 553 893 66 51 431 403 425 423 381 184 643 50 163 856 805 829 825 859 662 57 11 287 803 804 779 791 240 260 279 262 366 636 432 151 64 811 387 393 391 361 74 62 64 83 489 29 1374 742 1022 1414 2530 276 1283 289 34 51 668 254 479 1348 254 311 1095 250 429 329 2089 105 1900 283 796 309 97 586 961 1807 408 1305 0 772 357 128 1575404 793 1363 154 259 39 28 1310 218 98 51 437 644 1189 138 1 931 385 48 154 57 933 1020 370 207 822 264 58 38 201 31 3 2447 3087 588 48 1114 37 0 858 301 140 438 624 316 538 197 382 572 628 689 207 55 0 657 33 251 1033 879 931 2670 1 891 314 1392451 441 48 238 594 1678 615 2309 0 465 536 468 476 355 2176 1006 482 43 507 475 484 238 82 878 354 59 141 464 469 440 1 1188 375 953 53 2079 46 224 1444655 221 237 274 558 562 541 919 4 308 1243 28 42 787 602 576 578 167 997 110 281 137 630 0 182 0 1864 1038 471 50 1307 352 72 852 871 202 43 740 634 137 450 502 485 27 2616 58 59 102 156 469 479 479 917 301 308 315 845 125 440 467 446 442 729 65 775 1055 1063 1067 295 349 445 376 678 516 1908 435 485 531 496 1320 814 391 47 396 382 386 345 375 13 689 224 259 257 270 265 935 59 441 734 731 125 894 903 891 871 131 389 3203 3087 642 265 179 192 178 182 154 593 387 758 69 684 183 365 218 234 225 28 26 48 1074838 286 316 314 271 2767 51 2 350 251 929 0 31 610 73 0 98 534 415 233 342 84 60 456 85 367 165 41 990 861 142 624 349 175 133 153 667 697 54 655 884 676 1349 674 677 39 90 63 459 3250 1664 188 3203 680 0 40 329 442 447 355 776 687 103 459 325 15 501 373 92 0 434 2263 81 561 1611 778 658 1080190 708 0 382 481 121 475 2196 395 53 436 1 742 286 211 48 31 782 808 771 1542 289 850 259 75 635 50 0 8 30 733 1091 381 728 322 388 513 59 539 468 339 3351 90 305 769 159 77 56 1092 611 340 1744152 384 1806 0 1029 372 0 243 556 657 264 961 345 476 271 427 16 175 390 6 458 433 41 331 261 183 985 267 823 15 456 786 223 0 417 1073 387 522 686 788 288 1145 1043 583 755 630 1723 0 336 724 838 473 172 185 39 158 780 481 9 0 98 570 2077 0 81 46 213 317 349 737 621 0 617 120 36 2710 1421 0 364 170 0 372 2 0 353 1115 354 72 344 1189 61 743 433 962 44 119 2 892 57 595 690 610 869 0 0532 245 788 417 20 0 59 331 327 1394 313 1048 170 749 71 1669 84 372 976 987 1011 764 403 0 264 268 1142 47 111 286 303 312 295 26 8 365 562 42 378 01133 1126 1384 199 618 764 193 832 805 786 817 814 183 413 434 443 605 981 619 85 243 1064 499 504 483 53 43 662 618 626 477 830 400 1134 768 707 877 840 744 909 226 1113 457 1105 1113 295 329 1212 645 809 526 550 546 586 608 589 242 219 236 101 106 127 299 392 647 527 539 515 238 209 956 207 206 392 421 448 20 54 592 965 945 638 664 424 530 75 637 1658 1195 989 10201022 1346 1427 1457 609 270 63 485 605 1631 42 396 2474580 43 208 27 366 553 374 153 55 138 147 63 423 366 987 652 1818 877 7 28 38 1024 1021 367 343 330 750 42 307 1121 0 974 428 2287 20 239 407 646 1117472 819 114 662 69 1105 171 67 46 194 755 144 456 41 557 48 26 2094 89 389 6 1027 225 213 353 51 790 1 428 0 678 0 626 641 145 228 266 177 82 433 973 1253 627 1667 126 0 77 567 0 46 2 180 82 523 0 415 43 384 229 309 831 1499 47 510 163 272 44 288 1390 4241 12 1444 279 162 1182 666 1219 956 658 138 728 3005 770 2149 88 1600 294 195 36 27 456 116 11 87 1 271 146 570 840 214 160 1593 401 0 50 1712 238 1795 1638 264 76 0 409 1145 250 1004 844 1300 1798 776 772 53 537 103 1006 1571 1139 0 547 320 1058 329 348 328 399 706 67 596 551 67 959 567 1137687 33 1321 1795 64 332 0 469 784 73 506 1388 0 670 439 625 627 141 220 234 1434 226 220 232 1347 456 453 50 340 1299 530 952 1145 1096 1079 1122 791 393 53 635 615 0 113 1495 0 583 49 8 50 2322 508 63 7223 665 2619 49 709 643 921 376 449 26 197 63 353 458 876 675 105 60 1 55 817 0 407 900 384 413 54 953 923 946 2866 744 272 207 794 883 827 1755 1721920 1718 559 403 90 599 382 48 65 566 378 398 386 387 417 1019 572 551 640 637 672 26 693 257 577 203 455 639 518 38 264 311 282 292 0 0 163 1459 488 1053 1058 1001 1052 235 270 522 404 201 571 480 33 244 737 421 2243 736 699 770 888 742 547 41 1983 774 156 65 388 412 397 1405 808 718 725 550 367 750 499 716 810 805 1322 1562 33 1653 136 327 456 0 318 446 398 43 652 0 144 31 427 134 20 415 51 460 48 324 698 1125 174 586 10 520 537 511 196 48 2375 138 422 495 46 60 122 721 122 192 0 629 1398 245 250 180 21 2171 0 445 37 623 627 3922 108 2903 608 1653 46 375 150 764 957 705 664 822 229 45 584 903 504 348 464 239 175 344 462 28 50 776 550 671 113 2045 626 641 885 1332 1 37 805 1673 3812 434 358 622 586 175 755 711 810 1867 80 998 193 46 77 568 577 219 722 74 1992 1113 43 18 1043 665 348 0 1745 348 826 75 315 3 1867 0 73 20 1327 613 107 1312 45 245 374 1681 557 593 282 622 26 0 1387 282 0 2 321 182 671 202 723 973 75 1353 721 480 1534 906 984 36 117835 393 1109 175 576 21 59 195 552 124 1259 965 717 172 33 872 192 85 0 308 499 210 68 34 1193 698 45 487 986 711 7 582 708 652 94 816 24 442 1145593 538 479 1061 713 844 758 543 243 873 723 1231 895 370 523 1583 43 2 0 716 87 335 80 79 116 556 56 378 439 793 507 233 1154 323 848 580 225 22 158 52 23 1158 649 70 833 533 0 738 15 384 1126 20 0247 1217 73 941 1358 803 0 0 329 313 639 269 71 768 857 0 565 56 938 982 101 5 1971 200 1219 10642185 251 1051 36 121 527 650 80 703 1750 0 189 31 142 0 487 776 1146 492 0 319 474 247 522 1683 50 267 47 140 44 686 0 294 196 1440 1386 678 131 496 142
ENSG00000000003.10:003 646 396 868 535 175 601 41 12 240 34 87 1201 241 1236 0 110 319 381 504 143 457 54 30 503 291 498 779 585 3 313 324 0 1760 15 4 1279746 469 385 788 377 492 1770 959 808 549 511 25 484 367 31 162 300 74 907 24 394 888 321 621 1468 4 82 264 44 23 1049 7 498 416 121 790 571 999 1301969 150 387 1155 41 2103 186 392 305 641 464 824 525 427 539 324 171 171 421 888 905 404 293 316 0 696 474 552 0 741 13 42 44 264 241 43 422 361 425 395 446 431 437 419 170 180 172 168 267 255 248 267 367 351 387 411 401 406 411 418 1338 552 0 4 783 83 22 133 396 177 158 138 147 154 138 367 356 376 454 110 63 1097 482 599 358 401 612 687 219 1193 182 667 0 239 605 564 489 426 453 474 97 84 100 99 94 661 276 220 493 483 481 547 583 67 20 256 795 308 41 243 68 31 277 261 272 270 163 138 556 272 454 131 268 36 167 158 293 323 331 317 293 374 564 286 61 0 304 244 95 489 423 429 421 445 424 4 1711 2 17 367 316 335 342 110 58 674 136 7 22 203 226 252 257 228 38 46 206 412 60 407 26 55 16 23 340 664 1092 13 21 934 388 464 204 309 504 24 322 445 465 435 39 28 0 201 975 275 114 252 743 0 249 783 42 509 455 42 140 1667 114 988 268 74 253 380 435 291 608 201 122 82 974 31 51 251 265 670 210 593 371 149 209 712 327 35 31 300 0 177 315 609 38 1506 458 974 1408 1152 1363 200 2599 1872174 494 499 808 1599 549 1072 245 223 223 237 251 23 489 160 63 413 689 162 35 0 477 461 501 431 21 44 480 196 216 239 193 1580 795 12 771 385 681 738 691 678 172 1111 2057 1637 35 467 424 0 386 501 155 145 119 160 468 484 491 550 503 473 505 582 177 197 207 186 253 261 230 257 81 194 373 579 43 46 296 314 299 298 302 129 426 35 108 628 603 618 571 628 483 41 6 204 649 619 661 651 179 189 174 194 217 541 285 111 53 523 281 264 273 297 30 38 33 46 290 17 943 473 693 1145 1757 203 856 127 35 24 457 193 309 889 152 228 666 178 274 213 1354 66 1320 207 568 236 78 417 636 1498 257 910 0 558 281 90 1083220 699 877 61 157 24 15 785 150 73 32 352 441 762 93 1 607 277 35 118 53 602 704 204 130 419 170 33 30 146 23 0 1567 2093 411 35 712 26 0 592 162 94 310 413 228 365 147 256 400 420 496 167 39 0 471 21 217 737 618 615 1915 0 621 235 1071357 347 27 158 410 1146 441 1464 0 310 407 384 371 256 1331 680 370 34 378 381 353 142 61 663 238 51 106 288 294 257 1 808 273 683 32 1350 39 140 1004462 156 183 222 363 366 366 565 27 233 986 19 24 578 401 382 404 129 659 73 206 75 427 0 131 0 1325 783 378 38 962 260 56 665 704 163 24 496 397 101 375 367 326 22 2055 49 32 47 81 363 345 364 672 214 199 212 569 99 348 359 351 335 544 48 494 697 694 699 200 261 330 267 502 328 1207 249 349 364 362 889 586 242 25 254 251 280 244 269 11 447 152 147 171 161 167 594 51 326 474 543 78 704 709 681 690 82 238 2020 1868 446 180 133 144 132 144 126 393 266 533 53 457 123 264 148 163 163 27 19 36 717 501 204 242 214 223 1913 40 2 231 147 713 0 28 403 58 0 59 370 258 155 222 40 51 373 60 168 139 40 718 611 76 408 210 126 102 101 470 461 33 500 608 529 906 520 464 32 60 58 320 2175 1284 88 2491 518 0 25 209 339 303 261 524 508 92 335 202 7277 246 66 0 301 1541 58 416 1018 524 470 729 158 479 0 269 304 81 355 1496 297 22 304 1 513 211 166 37 21 551 527 628 1053 183 548 202 51 436 34 03 20 513 729 286 505 223 303 367 53 406 283 220 2250 71 163 536 103 61 34 604 312 239 1339 100 278 1249 0 722 277 0 163 401 453 194 659 248 324 174 295 16 69 279 2 324 259 29 203 188 149 785 178 572 12 277 515 119 0 442 663 278 344 472 572 201 836 827 400 565 414 1382 0 246 479 621 360 110 144 27 92 539 322 7 0 69 424 1172 1 45 34 150 221 249 579 384 0 506 77 19 1947 956 1 257 113 0241 0 0 279 776 267 48 281 798 40 506 301 648 29 61 2 620 33 344 471 388 578 0 0 323 181 476 249 14 0 30 217 223 1100 220 675 123 512 59 1122 65 270 680 737 703 472 284 0 207 157 781 29 78 226 233 242 235 17 7 328 422 38 283 0 890 853 978 160 494 496 138 609 577 610 612 563 137 323 321 349 431 683 483 63 184 834 389 386 348 31 29 452 410 449 360 582 267 820 584 565 632 608 501 512 113 749 362 774 824 215 243 796 424 505 378 377 362 420 442 464 183 183 186 68 80 76 207 271 433 376 365 373 163 144 583 149 144 278 281 295 16 29 430 710 714 492 495 263 372 52 441 1217 769 616 609 634 928 963 967 383 174 41 339 398 1309 27 230 1746 359 26 142 23 260 399 273 94 38 99 116 46 279 270 637 466 1204 595 4 28 31 664 716 234 249 228 541 27 224 977 0 685 279 1681 18 167 279 417 701 312 531 76 432 36 717 122 53 27 142 485 60 337 27 371 39 14 1368 63 272 5 738 161 152 228 47 609 1295 0 436 1 439 413 107 178 176 121 59 340 639 855 429 1158 95 0 61 402 0 35 1 147 61 340 0295 26 282 159 209 571 1026 29 370 122 200 28 207 1054 2827 9 1057 188 104 840 429 790 620 489 90 561 2019 493 1524 75 1092 199 95 25 26 310 85 15 65 0175 90 393 593 149 134 1079 271 0 1 0 1267 164 1430 1124 171 56 0 306 816 188 676 543 956 1191 534 519 35 387 65 654 1094 786 0 332 230 768 279 270 274 339 447 44 439 389 49 697 405 801 524 20 947 1208 39 265 0 301 546 45 352 998 1 493 281 440 431 97 154 185 943 187 189 177 919 368 284 31 242 915 354 627 906 808 860 869 571 250 48 434 412 0 88 1070 0 380 37 11 33 1662 341 40 6 153 497 1859 20 469 386 711 269 291 12 133 42 200 364 497 459 67 40 1 37 597 1 282 633 259 290 40 711 704 765 2079 609 212 112 588 619 610 1204 1226 557 1248371 273 56 474 275 34 46 418 285 327 302 303 297 713 410 386 466 482 493 22 506 174 468 168 344 470 419 40 208 253 252 224 0 0 87 1194 340 806 818 797 834 149 182 318 290 151 436 279 36 178 510 314 1599 541 527 567 588 528 407 36 1317 516 144 45 307 282 325 932 578 459 534 364 251 570 393 506 554 560 885 1017 29 1201 108 212 345 0 232 286 262 37 526 0118 23 282 77 17 265 33 317 33 188 490 758 144 451 8 409 420 394 134 29 1841 87 276 294 43 38 90 544 81 121 0 472 960 165 120 121 16 1599 0 348 28 457 442 2123 77 2019 395 1037 34 271 70 531 650 504 421 622 157 39 387 633 337 243 268 169 112 248 304 28 38 536 389 444 81 1502 479 402 685 886 128 578 1164 2680 270 244 412 391 131 522 500 545 111550 705 130 30 68 452 439 156 443 48 1266 759 34 9657 473 230 0 1162 192 495 52 227 1 1345 0 46 13 806 363 77 914 26 154 266 1162 398 367 203 439 25 0 915 205 0 1 216 104 461 136 510 638 52 920 489 346 1050 619 638 18 925 21 271 761 120 436 15 39 118 401 87 839 702 475 120 18 560 125 54 0182 355 125 29 23 816 535 33 343 679 491 6 395 472 456 81 498 16 356 751 486 398 379 669 463 588 486 429 148 567 539 1040 619 267 369 1177 37 1 0 501 68 247 53 61 73 428 34 280 303 504 348 119 736 183 590 370 150 11 129 31 20 818 515 44 597 414 0 470 6 253 786 13 0 163 879 52 636 931 643 1 0 264 162 440 189 46 606 508 0 430 39 612 660 59 5 1322 153 801 760 1420 165 750 25 75 388 415 52 498 1162 0 134 21 97 0 314 518 795 400 0 209 310 169 336 1251 34 155 34 116 36 500 0225 130 980 967 434 96 326 104
ENSG00000000003.10:004 494 264 661 358 147 484 24 13 143 31 58 684 145 854 0 91 272 223 358 91 330 48 31 419 184 403 548 498 3 208 245 0 1513 16 2 1079430 361 298 608 293 342 1176 591 555 398 361 24 362 225 23 93 222 33 613 24 224 728 253 509 944 5 66 194 43 22 655 5 319 309 104 618 362 667 858 651 122 255 727 41 1393 164 307 260 430 410 620 337 286 372 203 142 136 252 686 636 325 211 256 0 480 369 366 0 547 5 36 27 175 161 27 310 258 294 266 333 317 300 312 121 124 121 102 193 204 179 187 289 278 300 329 283 284 290 300 1036 386 0 4 549 62 21 87 272 130 141 131 129 131 83 281 284 299 353 88 61 834 307 475 279 310 470 554 151 727 105 496 0 166 495 363 354 344 337 368 71 64 75 82 75 448 195 166 365 371 348 402 415 57 16 229 579 226 23 178 48 23 219 191 218 227 117 129 353 220 330 105 156 27 127 104 247 262 274 258 238 291 384 227 53 0 241 148 81 325 348 336 357 359 346 0 1451 1 11 292 257 257 257 104 50 422 111 8 22 172 182 216 199 187 38 36 136 314 48 340 25 40 13 20 278 471 861 11 11 648 312 361 123 248 371 15 244 314 376 309 31 26 0 128 640 201 76 203 452 0 177 601 25 330 302 31 101 1187 77 660 193 59 165 246 312 188 424 144 75 54 617 23 43 154 223 459 127 395 282 115 185 498 221 35 21 261 0 110 222 484 28 1077 327 828 1001 744 868 170 1948 1388141 389 343 625 1057 371 738 187 172 187 178 176 27 367 116 54 335 415 131 35 0 368 342 353 332 12 41 346 136 156 181 142 1192 535 9 492 268 539 605 550 565 144 869 1660 1208 32 295 346 0 278 393 112 115 96 113 375 387 386 424 396 368 373 438 131 133 140 147 199 205 181 203 69 156 250 502 43 38 256 272 235 256 260 88 338 24 90 538 510 531 486 514 350 34 5 127 563 496 547 535 141 136 132 154 138 427 242 89 43 429 224 207 200 212 17 17 21 33 218 16 665 342 514 945 1306 178 610 107 38 22 355 155 239 585 94 163 477 136 216 151 953 66 921 155 422 208 59 276 476 1264 180 656 0 447 210 71 702 176 572 631 46 114 15 10 459 105 51 23 331 297 499 84 0 436 168 33 96 48 379 466 99 105 245 120 22 25 108 17 0 1152 1623 264 28 571 20 0 399 104 48 225 328 172 271 101 154 235 334 430 140 41 0 358 19 167 454 490 435 1486 0 477 150 831 279 273 25 134 238 705 325 1030 0 186 327 322 321 207 905 467 299 27 285 284 281 108 57 501 156 38 103 209 214 183 1 491 194 530 18 991 27 87 730 312 103 169 159 255 266 260 369 30 167 769 13 16 438 294 294 318 87 449 60 178 51 284 0 123 0 901 637 306 37 694 158 57 517 565 117 18 367 268 80 293 271 213 20 1632 43 28 28 51 316 280 285 434 170 142 163 461 67 296 306 289 285 380 35 363 526 532 538 156 206 262 171 379 201 831 187 271 283 268 664 422 140 24 195 181 218 171 205 8 336 101 134 142 123 142 399 46 239 337 365 71 541 589 569 562 71 153 1510 1268 305 153 101 114 108 115 114 256 207 341 44 365 91 157 111 122 126 29 16 35 504 396 188 180 179 183 1391 38 1 177 88 533 0 29 298 46 0 38 244 215 97 160 30 47 297 63 74 92 37 593 491 45 310 131 99 76 96 345 374 32 412 385 454 591 389 339 31 50 53 193 1634 1002 77 2043 399 0 20 125 293 226 217 353 386 86 250 150 6185 196 51 0 224 1047 54 286 634 354 272 527 128 333 0 215 220 58 222 977 251 15 213 1 333 148 141 32 20 449 418 527 702 115 359 128 41 314 33 00 14 361 581 207 353 164 258 270 42 343 203 156 1523 52 119 374 85 56 35 405 205 191 1028 69 204 921 0 521 218 0 107 268 316 126 450 226 283 138 217 13 33 219 3 233 194 27 133 134 128 661 150 395 8 211 321 81 0 294 524 170 243 403 339 126 701 694 300 474 301 1093 0 171 329 490 301 88 113 23 72 440 221 8 0 51 320 626 2 20 26 96 160 155 489 253 0 404 66 11 1217 647 0 218 87 0162 0 0 249 534 215 40 237 516 23 334 182 434 22 45 2 393 28 235 352 288 412 0 0 211 144 288 184 11 0 24 181 165 881 172 417 104 372 47 783 52 236 481 560 563 325 196 0 188 107 633 25 61 190 188 198 180 17 5 279 300 30 221 0 696 665 657 129 446 389 124 483 461 479 494 423 104 253 241 278 310 455 360 46 133 715 311 331 284 31 25 353 354 365 273 436 160 505 486 455 510 473 360 406 66 590 280 572 599 175 191 573 256 313 263 273 259 329 341 372 147 143 138 58 58 54 152 209 299 266 277 273 118 111 349 118 128 196 211 218 14 31 371 588 606 404 387 189 265 44 344 992 493 456 413 480 684 711 714 277 103 32 236 304 1107 17 168 1218 250 19 101 22 162 318 191 47 20 86 93 42 169 237 502 350 787 461 3 24 29 479 494 160 197 164 356 25 191 835 0 463 178 1246 14 135 216 263 556 222 402 60 280 16 543 99 49 26 115 369 30 213 30 261 36 14 1011 62 227 5 588 110 103 165 39 525 1200 0 349 1 285 276 96 139 114 88 35 256 475 607 296 725 75 0 47 285 0 25 1 116 47 235 0245 22 225 113 167 476 721 20 249 109 146 29 138 776 1846 7 874 137 76 558 257 582 473 341 69 458 1442 315 1039 62 705 171 47 20 15 217 69 15 48 0114 62 247 411 104 109 753 195 0 1 0 926 113 1120 748 133 43 0 269 631 155 517 312 665 881 347 344 32 291 43 460 831 513 0 221 174 582 236 233 213 280 351 40 293 274 36 559 298 537 435 12 623 920 20 198 0 216 410 38 289 786 1 364 210 326 333 103 118 150 587 146 140 152 567 306 208 33 173 670 275 453 729 677 706 676 416 181 40 290 281 0 70 711 0 262 26 10 29 1048 235 35 6 100 394 1366 11 324 250 572 197 220 10 124 37 146 288 344 349 51 41 1 27 491 1 225 492 155 186 36 579 560 599 1527 516 182 88 474 450 480 942 976 414 977 239 207 53 362 208 36 36 342 256 269 254 264 262 441 313 300 352 366 384 27 406 108 338 144 231 332 338 31 166 196 203 166 0 0 64 972 225 635 639 637 652 124 143 240 250 111 323 192 37 140 352 193 1184 441 427 432 433 388 285 40 976 314 118 38 253 240 282 696 381 302 327 243 146 445 312 394 364 467 701 798 24 837 88 132 267 0 145 198 210 34 415 090 15 191 76 18 178 32 226 24 121 321 540 125 327 1 331 352 330 103 27 1480 73 189 231 31 35 79 455 72 76 0 322 611 161 83 92 13 1243 0 281 24 294 328 1429 63 1273 245 772 25 218 49 343 472 380 326 506 97 37 240 531 247 212 199 107 94 171 213 24 29 416 252 349 50 1245 381 282 594 630 028 470 826 1801 170 182 297 292 97 336 398 364 746 44 436 79 22 61 373 321 132 298 33 973 528 31 8532 375 132 0 786 155 310 55 179 1 1037 0 34 6568 276 63 687 20 99 207 641 286 251 122 280 26 0627 141 0 1 143 56 335 93 374 466 43 681 380 281 826 435 418 15 763 23 208 515 83 325 10 42 74 240 68 570 501 373 100 15 412 71 54 0 131 244 68 17 24 625 471 36 269 465 417 3 294 377 266 64 372 10 313 544 412 361 326 456 315 438 344 338 122 373 388 831 402 189 230 865 31 1 0 300 56 170 29 56 51 330 28 241 235 363 270 96 455 144 390 238 103 10 89 23 20 552 402 40 411 342 0322 4 170 559 5 0 113 654 49 418 669 516 1 0211 52 336 146 33 470 330 0 369 31 394 446 47 3929 117 614 506 1065 126 507 19 59 332 317 45 305 816 0 104 21 76 0 240 319 623 337 0 169 194 130 256 945 29 102 33 98 34 392 0 161 108 717 762 305 81 251 62
Each column in this file corresponds to one patient file
each row in the first column is a specific exon on that geneId (labeled ENSG***)
and then every value in the cells below a particular patient is the RNA-seq value on that exon on that gene for that patient. This is the focus of the analysis, but there's a lot more file leg work that needs to be done.
This is just the previously build directory of patient gene-fusion files
donor_unique_id wgs_exclusion_white_gray dcc_project_code submitter_donor_id icgc_donor_id mar2016_donor santa_cruz_pilot validation_by_deep_seq TiN normal_wgs_submitter_specimen_id normal_wgs_icgc_specimen_id normal_wgs_submitter_sample_id normal_wgs_icgc_sample_id normal_wgs_aliquot_id normal_wgs_bwa_alignment_gnos_repo normal_wgs_bwa_alignment_gnos_id is_mar2016_normal_wgs_bwa_alignment normal_wgs_bwa_alignment_bam_file_name normal_wgs_minibam_gnos_repo normal_wgs_minibam_gnos_id is_mar2016_normal_wgs_minibam normal_wgs_minibam_bam_file_name tumor_wgs_specimen_count tumor_wgs_submitter_specimen_id tumor_wgs_icgc_specimen_id tumor_wgs_submitter_sample_id tumor_wgs_icgc_sample_id tumor_wgs_aliquot_idtumor_wgs_oxog_score tumor_wgs_ContEST tumor_wgs_Stars tumor_wgs_bwa_alignment_gnos_repo tumor_wgs_bwa_alignment_gnos_id is_mar2016_tumor_wgs_bwa_alignment tumor_wgs_bwa_alignment_bam_file_name tumor_wgs_minibam_gnos_repo tumor_wgs_minibam_gnos_id is_mar2016_tumor_wgs_minibam tumor_wgs_minibam_bam_file_name sanger_variant_calling_repo sanger_variant_calling_gnos_id sanger_variant_calling_file_name_prefix is_mar2016_sanger_variant_calling sanger_variant_calling_deprecated_gnos_id dkfz_embl_variant_calling_repo dkfz_embl_variant_calling_gnos_id dkfz_embl_variant_calling_file_name_prefix is_mar2016_dkfz_embl_variant_calling dkfz_embl_variant_calling_deprecated_gnos_id broad_variant_calling_repo broad_variant_calling_gnos_id broad_variant_calling_file_name_prefix is_mar2016_broad_variant_calling broad_variant_calling_deprecated_gnos_id muse_variant_calling_repo muse_variant_calling_gnos_id muse_variant_calling_file_name_prefix is_mar2016_muse_variant_calling broad_tar_variant_calling_repo broad_tar_variant_calling_gnos_id broad_tar_variant_calling_file_name_prefix is_mar2016_broad_tar_variant_calling normal_wgs_has_matched_rna_seq tumor_wgs_has_matched_rna_seq normal_rna_seq_submitter_specimen_id normal_rna_seq_icgc_specimen_id normal_rna_seq_submitter_sample_id normal_rna_seq_icgc_sample_id normal_rna_seq_aliquot_id normal_rna_seq_star_alignment_gnos_repo normal_rna_seq_star_alignment_gnos_id is_mar2016_normal_rna_seq_star_alignment normal_rna_seq_star_alignment_bam_file_name normal_rna_seq_tophat_alignment_gnos_repo normal_rna_seq_tophat_alignment_gnos_id is_mar2016_normal_rna_seq_tophat_alignment normal_rna_seq_tophat_alignment_bam_file_name tumor_rna_seq_specimen_count tumor_rna_seq_submitter_specimen_id tumor_rna_seq_icgc_specimen_id tumor_rna_seq_submitter_sample_id tumor_rna_seq_icgc_sample_idtumor_rna_seq_aliquot_id tumor_rna_seq_star_alignment_gnos_repo tumor_rna_seq_star_alignment_gnos_idis_mar2016_tumor_rna_seq_star_alignment tumor_rna_seq_star_alignment_bam_file_name tumor_rna_seq_tophat_alignment_gnos_repo tumor_rna_seq_tophat_alignment_gnos_id is_mar2016_tumor_rna_seq_tophat_alignment tumor_rna_seq_tophat_alignment_bam_file_name
BLCA-US::096b4f32-10c1-4737-a0dd-cae04c54ee33 Whitelist BLCA-US 096b4f32-10c1-4737-a0dd-cae04c54ee33 DO804 True True True 1.000000e-02 27461a27-26eb-4c2c-9c54-e16fbd32c615 SP1682 e0fccaf5-925a-41f9-b87c-cd5ee4aecb59 SA5237 e0fccaf5-925a-41f9-b87c-cd5ee4aecb59 https://gtrepo-osdc-tcga.annailabs.com/ f22a72c5-73c8-478d-b03e-04599b9d5321 True PCAWG.67455c36-aa47-4cc4-8b6d-9a9012b616ed.bam https://gtrepo-osdc-tcga.annailabs.com/ 7e442040-f6ea-11e5-bd75-997f5888a0e8 False PCAWG.67455c36-aa47-4cc4-8b6d-9a9012b616ed_minibam.bam 1 52f538ef-b05d-4c76-9976-ce6d49158016 SP1677 301d6ce3-4099-4c1d-8e50-c04b7ce91450 SA5195 301d6ce3-4099-4c1d-8e50-c04b7ce91450 87.52 0.1 5.0 https://gtrepo-osdc-tcga.annailabs.com/ a6e8dd23-c8a5-445a-ae4b-b9f92ed6a73e True PCAWG.a833602e-7ee7-442b-9bf9-f6489cd64ba2.bam https://gtrepo-osdc-tcga.annailabs.com/ 7e442040-f6ea-11e5-bd75-997f5888a0e8 False PCAWG.a833602e-7ee7-442b-9bf9-f6489cd64ba2_minibam.bam https://gtrepo-osdc-tcga.annailabs.com/ 8935fe36-ceec-11e5-bedc-767d4d100685301d6ce3-4099-4c1d-8e50-c04b7ce91450 True 5230346f-987e-44c3-b9fe-dddb5829e247 https://gtrepo-osdc-tcga.annailabs.com/ 4269588d-5012-4eee-ab9a-9c48897dae69 301d6ce3-4099-4c1d-8e50-c04b7ce91450 True https://gtrepo-osdc-tcga.annailabs.com/ ac34e35d-21b1-4b11-b42d-155cba1a547f301d6ce3-4099-4c1d-8e50-c04b7ce91450 True d12904ff-4ce6-4d7b-a0d7-69e18a3822cc https://gtrepo-osdc-tcga.annailabs.com/ 48077833-99ed-49c6-88a1-80cd2e50755a 301d6ce3-4099-4c1d-8e50-c04b7ce91450 True https://gtrepo-osdc-tcga.annailabs.com/ 38ce6165-c324-4642-89cf-984d738ee08a 301d6ce3-4099-4c1d-8e50-c04b7ce91450 True False True 152f538ef-b05d-4c76-9976-ce6d49158016 SP1677 22e154de-0e3b-443b-8420-48d68d6c1ce4 SA5213 22e154de-0e3b-443b-8420-48d68d6c1ce4 https://gtrepo-osdc-tcga.annailabs.com/ a63c9c0a-c8aa-44dc-8915-08f55109a5c9 True PCAWG.f4288632-a94f-4777-a5d6-1a76b12abcc5.STAR.v1.bam https://gtrepo-osdc-tcga.annailabs.com/ 81438f7c-ee87-44a7-acd1-562ec8f386f0 True PCAWG.f4288632-a94f-4777-a5d6-1a76b12abcc5.TopHat2.v1.bam
BLCA-US::178b28cd-99c3-48dc-8d09-1ef71b4cee80 Whitelist BLCA-US 178b28cd-99c3-48dc-8d09-1ef71b4cee80 DO555 True True True 0 cd3cfb26-e66f-408e-81f6-3b61c247c976 SP1135 c1da8eed-4919-4ba5-a735-3fba476c18a7 SA1598 c1da8eed-4919-4ba5-a735-3fba476c18a7 https://gtrepo-osdc-tcga.annailabs.com/ 964bac8f-43cc-4a47-b233-53798d287029 True PCAWG.13985b6b-d7b6-4efd-9c53-288f4d269a0c.bam https://gtrepo-osdc-tcga.annailabs.com/ 0b6a5d16-e617-11e5-ad33-d98536d081eeFalse PCAWG.13985b6b-d7b6-4efd-9c53-288f4d269a0c_minibam.bam 1 59d6683f-5eb7-493d-8e8e-78b88be2cd70 SP1132 4838b5a9-968c-4178-bffb-3fafe1f6dc09 SA1556 4838b5a9-968c-4178-bffb-3fafe1f6dc0954.55 0.1 5.0 https://gtrepo-osdc-tcga.annailabs.com/ 437e11a0-4137-4614-9f64-c5e798c8bb33True PCAWG.af830047-822a-4dcc-88bc-68f7440a208d.bam https://gtrepo-osdc-tcga.annailabs.com/ 0b6a5d16-e617-11e5-ad33-d98536d081ee False PCAWG.af830047-822a-4dcc-88bc-68f7440a208d_minibam.bam https://gtrepo-osdc-tcga.annailabs.com/ 714e7b6a-d34a-11e5-90f0-f8135c6878de 4838b5a9-968c-4178-bffb-3fafe1f6dc09 True c0387aa4-9937-45f7-bf3a-e2da65457738 https://gtrepo-osdc-tcga.annailabs.com/ 875fdb54-76ae-11e5-abee-bff16f24f4a1 4838b5a9-968c-4178-bffb-3fafe1f6dc09 True https://gtrepo-osdc-tcga.annailabs.com/ d989e42d-354c-4652-9921-27f79ba31c2e 4838b5a9-968c-4178-bffb-3fafe1f6dc09 True f3c6d06b-09ff-4e0d-821d-80bd2b04106f https://gtrepo-osdc-tcga.annailabs.com/ d9ec79b7-0ccb-4312-b84d-b90200eb77bf 4838b5a9-968c-4178-bffb-3fafe1f6dc09 True https://gtrepo-osdc-tcga.annailabs.com/ 9f6910ec-80dc-4270-b415-26c00f5ad281 4838b5a9-968c-4178-bffb-3fafe1f6dc09 True False True 159d6683f-5eb7-493d-8e8e-78b88be2cd70 SP1132 f154cc00-e118-4d4c-b9d2-2f1f71e0a964 SA1580 f154cc00-e118-4d4c-b9d2-2f1f71e0a964 https://gtrepo-osdc-tcga.annailabs.com/ 2c4bd7a6-721a-4cd1-aa40-90cecb01c32c True PCAWG.5c2ab9dd-c1ed-4d57-b68d-56a7b52b80e0.STAR.v1.bam https://gtrepo-osdc-tcga.annailabs.com/ 4a81f567-fb9b-4561-b2b7-c099c206a2ce True PCAWG.5c2ab9dd-c1ed-4d57-b68d-56a7b52b80e0.TopHat2.v1.bam
BLCA-US::1e308b12-0590-4dae-94d0-a539fcf25df7 Whitelist BLCA-US 1e308b12-0590-4dae-94d0-a539fcf25df7 DO479 True True True 0 59b99c9a-d1c0-4cc0-953b-4358bcf9f392 SP968 d6e91f4c-38c0-4393-9cb7-be076663dff3 SA3784 d6e91f4c-38c0-4393-9cb7-be076663dff3 https://gtrepo-osdc-tcga.annailabs.com/ fa36e89d-55b8-4c72-9392-80113efde076 True PCAWG.c878fe80-0a2e-43d2-ab62-1214fc34c282.bam https://gtrepo-osdc-tcga.annailabs.com/ 58624910-e5a1-11e5-8a85-b49cebf72b8fFalse PCAWG.c878fe80-0a2e-43d2-ab62-1214fc34c282_minibam.bam 1 e9889071-4c6e-4761-9d65-06c6b5989fb7 SP967 c66c92d5-df65-46e6-861d-d8a98808e6a3 SA3742 c66c92d5-df65-46e6-861d-d8a98808e6a386.05 0.1 5.0 https://gtrepo-osdc-tcga.annailabs.com/ 416911eb-e10f-4edd-8f07-5e87b0228a11True PCAWG.066b5025-1a70-4db4-bd98-964b8c9939c3.bam https://gtrepo-osdc-tcga.annailabs.com/ 58624910-e5a1-11e5-8a85-b49cebf72b8f False PCAWG.066b5025-1a70-4db4-bd98-964b8c9939c3_minibam.bam https://gtrepo-osdc-tcga.annailabs.com/ 67959d40-d34c-11e5-bc3a-f8135c6878de c66c92d5-df65-46e6-861d-d8a98808e6a3 True 838819c6-29d1-4d45-b534-d198dfffdaa9 https://gtrepo-osdc-tcga.annailabs.com/ a44f0d88-76af-11e5-b61f-84cb5485c5b1 c66c92d5-df65-46e6-861d-d8a98808e6a3 True https://gtrepo-osdc-tcga.annailabs.com/ 5c58c28e-b8b8-4137-bf8d-526fffab8338 c66c92d5-df65-46e6-861d-d8a98808e6a3 True 7e45c6f6-0b5c-474f-b251-2bf58be35290 https://gtrepo-osdc-tcga.annailabs.com/ 854c515b-bade-4f10-8f24-a46b0abd1507 c66c92d5-df65-46e6-861d-d8a98808e6a3 True https://gtrepo-osdc-tcga.annailabs.com/ 595384e4-c0e1-47d2-a1e3-c1aa7f9eeea6 c66c92d5-df65-46e6-861d-d8a98808e6a3 True False True 1e9889071-4c6e-4761-9d65-06c6b5989fb7 SP967 429f0e9d-c160-4b36-a31b-dab1097c6129 SA3760 429f0e9d-c160-4b36-a31b-dab1097c6129 https://gtrepo-osdc-tcga.annailabs.com/ 5e5f155b-0c8c-4917-b47c-606fda32b0e8 True PCAWG.ba7d499b-049b-4ba2-be02-e513f81d453e.STAR.v1.bam https://gtrepo-osdc-tcga.annailabs.com/ 4c45ff2a-309f-4167-936e-e5b894ce6b79 True PCAWG.ba7d499b-049b-4ba2-be02-e513f81d453e.TopHat2.v1.bam
BLCA-US::24f21425-b001-4986-aedf-5b4dd851c6ad Whitelist BLCA-US 24f21425-b001-4986-aedf-5b4dd851c6ad DO689 True True False 1.000000e-02 1c7630ed-6b1c-4569-a15c-e296772868de SP1425 f88b2f4c-15f1-4808-bcec-89abc7466de6 SA3769 f88b2f4c-15f1-4808-bcec-89abc7466de6 https://gtrepo-osdc-tcga.annailabs.com/ b2a9fda3-15e8-4a8b-8a8a-195d72573423 True PCAWG.c3ffa75b-de27-4cc6-b713-b32c51f5bee5.bam https://gtrepo-osdc-tcga.annailabs.com/ 3456a156-e8ee-11e5-bd56-a21f777315da False PCAWG.c3ffa75b-de27-4cc6-b713-b32c51f5bee5_minibam.bam 1 967443e3-35c3-4f41-9bb5-dc899d290806 SP1419 973d0577-8ca4-44a1-817f-1d3c1bada151 SA3721 973d0577-8ca4-44a1-817f-1d3c1bada151 87.09 0.1 4.5 https://gtrepo-osdc-tcga.annailabs.com/ d2e25eb8-8899-4ba5-a2f1-0a69ba97cef2 True PCAWG.bd9f7681-6ed4-4f60-8db9-eb7ab0d4a7e7.bam https://gtrepo-osdc-tcga.annailabs.com/ 3456a156-e8ee-11e5-bd56-a21f777315da False PCAWG.bd9f7681-6ed4-4f60-8db9-eb7ab0d4a7e7_minibam.bam https://gtrepo-osdc-tcga.annailabs.com/ bd31974a-cfdc-11e5-b3ed-eaf5899203f5973d0577-8ca4-44a1-817f-1d3c1bada151 True d1fc904c-eb10-4d61-adea-58fb70412b7a https://gtrepo-osdc-tcga.annailabs.com/ 4508880d-8850-471e-9170-dddff85fd241 973d0577-8ca4-44a1-817f-1d3c1bada151 True https://gtrepo-osdc-tcga.annailabs.com/ 927237c0-427d-4182-9023-fa42b94c6d3b973d0577-8ca4-44a1-817f-1d3c1bada151 True 6f399d0f-e0b4-4ae2-9d2a-e7c141825708 https://gtrepo-osdc-tcga.annailabs.com/ 239d1ef8-53b5-4571-a663-cfc651ec2e8a 973d0577-8ca4-44a1-817f-1d3c1bada151 True https://gtrepo-osdc-tcga.annailabs.com/ 4c1298ba-2a99-4e2c-859d-b0c7dec2fce0 973d0577-8ca4-44a1-817f-1d3c1bada151 True False True 1967443e3-35c3-4f41-9bb5-dc899d290806 SP1419 80cdd385-2a6a-4d59-81c7-f36786637323 SA3745 80cdd385-2a6a-4d59-81c7-f36786637323 https://gtrepo-osdc-tcga.annailabs.com/ 527cc5b2-8716-44ae-9d63-8f16c4857184 True PCAWG.65e2deab-5ba3-4d8c-83a9-69b29e0e8e40.STAR.v1.bam https://gtrepo-osdc-tcga.annailabs.com/ 90f6db49-d0e0-4b2b-b859-01fe4b90faaa True PCAWG.65e2deab-5ba3-4d8c-83a9-69b29e0e8e40.TopHat2.v1.bam
This is the file that references those long complicated fileheaders from earlier to a specific patient id.
We need this because we also have...
aliquot_id study project_code icgc_donor_id icgc_specimen_id icgc_sample_id submitted_donor_id submitted_specimen_id submitted_sample_id specimen_type donor_id specimen_id sample_id date file_name filesize md5_checksum analysis_id uri center_name platform platform_model lib_id rg_label files files_blacklist pilot_63 includes_spike_ins spike_ins_fasta spike_ins_concentration library_type library_strategy accession state is_tumour file_type unique_donor_id wgs_white_black_graywgs_exclusion_white_gray donor_unique_id tcga_donor_uuid donor_sex donor_vital_status donor_diagnosis_icd10 first_therapy_type first_therapy_response donor_age_at_diagnosis donor_survival_time donor_interval_of_last_followup tobacco_smoking_history_indicator tobacco_smoking_intensity alcohol_history alcohol_history_intensity donor_wgs_included_excluded tcga_specimen_uuid tcga_sample_uuid organ_system histology_abbreviation histology_tier1 histology_tier2 histology_tier3 histology_tier4 tumour_histological_code tumour_histological_type tumour_stage tumour_grade percentage_cellularity level_of_cellularity tcga_expert_re.review tumour_histological_comment specimen_donor_treatment_type rna_seq_specimen_id Color (RGB code) rna_seq_aliquot_id wgs_aliquot_id GTex.tissue tumor.normal matched_wgs_aliquot_id
b337121c-9821-4644-820e-b8c477f6c38a Brain Glioblastoma Multiforme - TCGA, US GBM-US DO10908 SP23639 SA136044 737b35e1-d668-4fce-9b6e-76946c7952b6 96881d37-7a3e-4910-b897-19453118fe7c b337121c-9821-4644-820e-b8c477f6c38a Primary tumour - solid tissue 737b35e1-d668-4fce-9b6e-76946c7952b6 96881d37-7a3e-4910-b897-19453118fe7c TCGA-27-2523-01A-01R-1850-01 2013-12-17T00:55:04Z G17483.TCGA-27-2523-01A-01R-1850-01.2.tar.gz 6850833438 d443ea4bbd917b43bd3bc20882f07eb2 52918733-0b2d-462b-8784-70bd148d9ffe https://cghub.ucsc.edu/cghub/data/analysis/download/52918733-0b2d-462b-8784-70bd148d9ffe BI ILLUMINA Illumina HiSeq 2000 7290.WR29324.Solexa-91309.C0HTRACXX120406.P C0HTR.3 G17483.TCGA-27-2523-01A-01R-1850-01.2.bam NA FALSENA NA RNA-Seq yes fastq GBM-US::737b35e1-d668-4fce-9b6e-76946c7952b6 Whitelist Whitelist GBM-US::737b35e1-d668-4fce-9b6e-76946c7952b6 737b35e1-d668-4fce-9b6e-76946c7952b6 male deceased C71.9 63 489 NA NA Included 96881d37-7a3e-4910-b897-19453118fe7c b337121c-9821-4644-820e-b8c477f6c38a BRAIN, & CRANIAL NERVES, & SPINAL CORD, (EXCL. VENTRICLE, CEREBELLUM) CNS-GBM NEURAL_CREST CNS Diffuse glioma Glioblastoma '9440/3 Glioblastoma, NOS 85 85-85 SP23639 #615421 b337121c-9821-4644-820e-b8c477f6c38a d60f54f5-b154-42c4-99fb-cea4e7a33dc7 Brain tumor d60f54f5-b154-42c4-99fb-cea4e7a33dc7
612ef912-5a28-4c11-8703-3376f51afef5 Brain Glioblastoma Multiforme - TCGA, US GBM-US DO10975 SP23769 SA138622 74139255-a635-4c87-814d-3dd04ed630a8 5e92a5d5-77a4-401a-ade3-e01c95302ec0 612ef912-5a28-4c11-8703-3376f51afef5 Primary tumour - solid tissue 74139255-a635-4c87-814d-3dd04ed630a8 5e92a5d5-77a4-401a-ade3-e01c95302ec0 TCGA-06-0190-01A-01R-1849-01 2013-12-17T00:56:04Z G17214.TCGA-06-0190-01A-01R-1849-01.2.tar.gz 6283869181 4eddd342a530b2fbd5b30e7bda3998fd 263668a7-e877-4311-9c76-13cf23b1e811 https://cghub.ucsc.edu/cghub/data/analysis/download/263668a7-e877-4311-9c76-13cf23b1e811 BI ILLUMINA Illumina HiSeq 2000 7290.WR29124.Solexa-89509.C0FVUACXX120313.P C0FVU.2 G17214.TCGA-06-0190-01A-01R-1849-01.2.bam NA FALSENA NA RNA-Seq yes fastq GBM-US::74139255-a635-4c87-814d-3dd04ed630a8 Whitelist Whitelist GBM-US::74139255-a635-4c87-814d-3dd04ed630a8 74139255-a635-4c87-814d-3dd04ed630a8 male deceased C71.9 62 317 NA NA Included 5e92a5d5-77a4-401a-ade3-e01c95302ec0 612ef912-5a28-4c11-8703-3376f51afef5 BRAIN, & CRANIAL NERVES, & SPINAL CORD, (EXCL. VENTRICLE, CEREBELLUM) CNS-GBM NEURAL_CREST CNS Diffuse glioma Glioblastoma '9440/3 Glioblastoma, NOS NA SP23769 #615421 612ef912-5a28-4c11-8703-3376f51afef5 c065761d-f775-457f-bda0-4c7c257a701e Braintumor c065761d-f775-457f-bda0-4c7c257a701e
56a705f4-fd28-44ff-8a3c-85bc4300c760 Brain Glioblastoma Multiforme - TCGA, US GBM-US DO11046 SP23925 SA141293 e17a6048-7a72-42c0-ad3f-97cbff02bc9f b89a4d5d-ee24-4052-b454-b67169328737 56a705f4-fd28-44ff-8a3c-85bc4300c760 Primary tumour - solid tissue e17a6048-7a72-42c0-ad3f-97cbff02bc9f b89a4d5d-ee24-4052-b454-b67169328737 TCGA-19-2629-01A-01R-1850-01 2013-12-17T00:55:03Z G17640.TCGA-19-2629-01A-01R-1850-01.2.tar.gz 8005247390 993e83cdfb12080c2df290066ca2f684 d0dc97b1-0dd1-40b0-89c5-f7cc748d8ecf https://cghub.ucsc.edu/cghub/data/analysis/download/d0dc97b1-0dd1-40b0-89c5-f7cc748d8ecf BI ILLUMINA Illumina HiSeq 2000 7290.WR29415.Solexa-90571.C0HTPACXX120405.P C0HTP.2 G17640.TCGA-19-2629-01A-01R-1850-01.2.bam NA FALSENA NA RNA-Seq yes fastq GBM-US::e17a6048-7a72-42c0-ad3f-97cbff02bc9f Whitelist Whitelist GBM-US::e17a6048-7a72-42c0-ad3f-97cbff02bc9f e17a6048-7a72-42c0-ad3f-97cbff02bc9f male deceased C71.9 60 737 NA NA Included b89a4d5d-ee24-4052-b454-b67169328737 56ffaa35-814c-4c0b-b3c6-d4514d34fec2 BRAIN, & CRANIAL NERVES, & SPINAL CORD, (EXCL. VENTRICLE, CEREBELLUM) CNS-GBM NEURAL_CREST CNS Diffuse glioma Glioblastoma '9440/3 Glioblastoma, NOS 85 85-85 SP23925 #615421 56a705f4-fd28-44ff-8a3c-85bc4300c760 56ffaa35-814c-4c0b-b3c6-d4514d34fec2 Brain tumor 56ffaa35-814c-4c0b-b3c6-d4514d34fec2
28239a0e-9990-49ef-a159-ba63fb078c77 Brain Glioblastoma Multiforme - TCGA, US GBM-US DO11148 SP24129 SA144446 0078b0c4-68a9-483b-9aab-61156d263213 f2ffa9ff-86d6-41ef-92e7-7f87e981985b 28239a0e-9990-49ef-a159-ba63fb078c77 Primary tumour - solid tissue 0078b0c4-68a9-483b-9aab-61156d263213 f2ffa9ff-86d6-41ef-92e7-7f87e981985b TCGA-14-1034-01A-01R-1849-01 2013-12-17T00:53:02Z G17473.TCGA-14-1034-01A-01R-1849-01.2.tar.gz 4827624481 14a341c7a1dac456e0e9d419551a2c04 98f2d5fa-7957-4a71-bb46-728ff20776ae https://cghub.ucsc.edu/cghub/data/analysis/download/98f2d5fa-7957-4a71-bb46-728ff20776ae BI ILLUMINA Illumina HiSeq 2000 7290.WR29324.Solexa-91276.C0HTRACXX120406.P C0HTR.3 G17473.TCGA-14-1034-01A-01R-1849-01.2.bam NA FALSENA NA RNA-Seq yes fastq GBM-US::0078b0c4-68a9-483b-9aab-61156d263213 Whitelist Whitelist GBM-US::0078b0c4-68a9-483b-9aab-61156d263213 0078b0c4-68a9-483b-9aab-61156d263213 female deceased C71.9 60 485 NA NA Included f2ffa9ff-86d6-41ef-92e7-7f87e981985b 28239a0e-9990-49ef-a159-ba63fb078c77 BRAIN, & CRANIAL NERVES, & SPINAL CORD, (EXCL. VENTRICLE, CEREBELLUM) CNS-GBM NEURAL_CREST CNS Diffuse glioma Glioblastoma '9440/3 Glioblastoma, NOS NA SP24129 #615421 28239a0e-9990-49ef-a159-ba63fb078c77 7cae6c0b-36fe-411b-bbba-093a4c846d84 Braintumor 7cae6c0b-36fe-411b-bbba-093a4c846d84
So each file that contains the information on the extracted tumor as a fileheader similar to the patient ones, but different. In order to match the tumor to the patient it came from, we need the patient reference file to get the patient id, and the tumor reference file (this one) to get the patient id and link the two together. If you're just interested in fixing the analysis parts of the code, don't worry too much about this part. This is what the summary_matching.py file does.
Take the previously built gene-fusion files and add details about exons and location
Genefinder.RNADonorId() will create a new directory called "patient_fusions_with_exons". In here you'll find all the same files from Referenced_patient_data, except now for each fusion in one of those files, you'll see all the exons contained within each gene, as well as their start and stop location.
So this file from Referenced_patient_data
geneA geneA orientation geneB geneB orientation chr1 position chr1 orientation chr2 position chr2 orientation
./patient_data/0a6be23a-d5a0-4e95-ada2-a61b2b5d9485.pcawg_consensus_1.6.161116.somatic.sv.bedpe
ERG - TMPRSS2 - chr21 39867712 + chr21 42872048 -
ERG - TMPRSS2 - chr21 39883066 - chr21 42871868 +
will be converted to
geneA geneB
ERG TMPRSS2
ENSG00000184012 TMPRSS2 - 42872048
chr21 -
1 42880008 42880086
2 42870046 42870116
3 42866283 42866505
4 42861434 42861520
5 42860321 42860440
6 42852403 42852529
7 42851099 42851209
8 42848504 42848547
9 42845252 42845423
10 42843733 42843908
11 42842575 42842670
12 42840323 42840465
13 42839661 42839813
14 42836478 42838080
1 42879877 42879909
2 42870046 42870116
3 42866283 42866505
4 42861434 42861520
5 42860321 42860440
6 42852403 42852529
7 42851099 42851209
8 42848504 42848547
9 42845252 42845423
10 42843733 42843908
11 42842575 42842670
12 42840323 42840465
13 42839661 42839813
14 42837936 42838080
1 42902912 42903043
2 42901900 42902145
3 42870046 42870116
4 42866283 42866505
5 42861434 42861520
6 42860321 42860440
7 42852403 42852529
8 42851099 42851209
9 42848504 42848547
10 42845252 42845423
11 42843733 42843908
12 42842575 42842670
13 42840323 42840465
14 42839661 42839813
1 42878372 42878531
2 42870046 42870116
3 42866283 42866505
ENSG00000157554 ERG - 39867712
chr21 +
1 39870287 39870407
2 39817327 39817544
3 39795332 39795483
4 39775428 39775631
5 39774479 39774559
6 39772496 39772567
7 39764298 39764366
8 39763581 39763637
9 39762917 39762964
10 39751949 39755845
1 39956768 39956824
2 39947586 39947671
3 39795332 39795483
4 39775428 39775631
5 39774479 39774559
6 39764298 39764366
7 39763581 39763637
8 39762917 39762964
9 39751949 39755845
1 39956768 39956869
2 39947586 39947671
3 39817327 39817544
4 39795332 39795483
5 39775428 39775631
6 39774479 39774559
7 39764298 39764366
8 39763581 39763637
9 39762917 39762964
10 39751949 39755845
1 40033582 40033618
2 39956768 39956869
3 39947586 39947671
4 39817327 39817544
5 39795332 39795483
6 39775428 39775631
7 39774479 39774559
8 39772496 39772567
9 39764298 39764366
10 39763581 39763637
11 39762917 39762964
12 39751949 39755845
1 39870287 39870400
2 39795332 39795483
3 39775428 39775631
4 39774479 39774559
5 39772496 39772567
6 39764298 39764366
7 39763581 39763637
8 39762917 39762964
9 39755048 39755845
1 40032446 40032591
2 39956768 39956869
3 39947586 39947671
4 39817327 39817544
5 39795332 39795483
6 39775428 39775631
7 39774479 39774559
8 39772496 39772567
9 39764298 39764366
10 39763581 39763637
11 39762917 39762964
12 39755213 39755845
geneA geneB
ERG TMPRSS2
ENSG00000184012 TMPRSS2 - 42871868
chr21 +
1 42880008 42880086
2 42870046 42870116
3 42866283 42866505
4 42861434 42861520
5 42860321 42860440
6 42852403 42852529
7 42851099 42851209
8 42848504 42848547
9 42845252 42845423
10 42843733 42843908
11 42842575 42842670
12 42840323 42840465
13 42839661 42839813
14 42836478 42838080
1 42879877 42879909
2 42870046 42870116
3 42866283 42866505
4 42861434 42861520
5 42860321 42860440
6 42852403 42852529
7 42851099 42851209
8 42848504 42848547
9 42845252 42845423
10 42843733 42843908
11 42842575 42842670
12 42840323 42840465
13 42839661 42839813
14 42837936 42838080
1 42902912 42903043
2 42901900 42902145
3 42870046 42870116
4 42866283 42866505
5 42861434 42861520
6 42860321 42860440
7 42852403 42852529
8 42851099 42851209
9 42848504 42848547
10 42845252 42845423
11 42843733 42843908
12 42842575 42842670
13 42840323 42840465
14 42839661 42839813
1 42878372 42878531
2 42870046 42870116
3 42866283 42866505
ENSG00000157554 ERG - 39883066
chr21 -
1 39870287 39870407
2 39817327 39817544
3 39795332 39795483
4 39775428 39775631
5 39774479 39774559
6 39772496 39772567
7 39764298 39764366
8 39763581 39763637
9 39762917 39762964
10 39751949 39755845
1 39956768 39956824
2 39947586 39947671
3 39795332 39795483
4 39775428 39775631
5 39774479 39774559
6 39764298 39764366
7 39763581 39763637
8 39762917 39762964
9 39751949 39755845
1 39956768 39956869
2 39947586 39947671
3 39817327 39817544
4 39795332 39795483
5 39775428 39775631
6 39774479 39774559
7 39764298 39764366
8 39763581 39763637
9 39762917 39762964
10 39751949 39755845
1 40033582 40033618
2 39956768 39956869
3 39947586 39947671
4 39817327 39817544
5 39795332 39795483
6 39775428 39775631
7 39774479 39774559
8 39772496 39772567
9 39764298 39764366
10 39763581 39763637
11 39762917 39762964
12 39751949 39755845
1 39870287 39870400
2 39795332 39795483
3 39775428 39775631
4 39774479 39774559
5 39772496 39772567
6 39764298 39764366
7 39763581 39763637
8 39762917 39762964
9 39755048 39755845
1 40032446 40032591
2 39956768 39956869
3 39947586 39947671
4 39817327 39817544
5 39795332 39795483
6 39775428 39775631
7 39774479 39774559
8 39772496 39772567
9 39764298 39764366
10 39763581 39763637
11 39762917 39762964
12 39755213 39755845
So you can see that the original gene-fusion file had 2 gene fusions, meaning there were a total of 4 genes involved in that file. The new file separates each gene and underneath it, gives all the exon information for each gene.
side note: in Genefinder.py you'll see two functions getExonFreq() and checkExonNumbers(). Those are tests I wrote just to get an idea of what kind of results I was getting for finding exons in that first file. Just stuff like how many occurrences of a specific number I was getting, or how many genes had overlapping numbers, etc. There's no call to those functions in the main operation of the code, so feel free to call them specifically if you're trying to fix that issue. Or if they're not super easy to follow (I didn't comment them cause it was sort of just hacked together pretty quickly), you can write your own inside that file using those arguments.
Next, file_creation.GroupCancers() will create separate directories and put each patient file in the cancer group that they belong in. The reason for this is because when analyzing one patient, we want to look at their RNA-seq values relative to only the other patients with the same cancer type. This is another aspect Dr. Yang can help clarify for you.
After this runs, you'll see a new directory called "CancerType_Groups". Those previous files with exon locations will be sorted into subdirectories, each labeled with the cancer name, within this one. It's sorted this way so that we know which other files to compare the data against.
Now we're up to the part that you'll be focusing on.
note: this is by far the slowest part. I wrote it for results, not for optimization. You can see for yourself it's O(n 3). However, it's easily adjustable to just run for results on specific cancer types. You don't need to run the script for the entirety of the data set.
filecreation.EvaluatePatientGroup() looks at each exon on each gene for each patient within a cancer group. What it then does is takes that exon's score, as well as the score for that same exon on the same gene, but from all the patients with the same cancer but that don't have that gene fusion.
Basically, think about it like this...
- Every patient (every human, really) has gene "A" (we'll just call it A).
- Let's say we have 3 lung cancer patients total;
Patient 1 has gene fusions
A-B, D-K and C-F
Patient 2 has gene fusions
C-R, G-D and A-Q
Patient 3 has gene fusions
D-F, Q-G and C-L
Now, when we're looking at Patient 1, we look at each individual gene, starting with A.
Then we first look at every other patient in our group and see which ones of them don't have A involved
in any gene fusions at all.
In this case, it's just Patient 3.
Now Patient 3 still has gene A in their genome and the RNA-seq file contains exon scores for each exon on that gene.
So we collect the scores of each exon number on gene A for Patient 1 and of each exon on gene A for Patient 3
We convert this array of scores to an array of z scores for each exon (line 208 in file_creation.py)
This is to measure the statistical difference of the exons involved in fusions
versus the exons involved in normally behaving genes.
That last part is is the part you may want to consider changing.
The zscores are used for the T-test, but a T-test isn't really suited for this type of data
At the end of this, you'll have a new directory called "Results". Inside here, you'll see subdirectories labeled by cancer name. Inside each of those, you'll see files with familiar looking file prefixes. Remember the files before that had each individual gene with the exons and their locations? Now those same files have had the associated zscores for each of those exons added to that information. Below is part of one of those files (just the first two individual genes aka, one gene fusion)
ENSG00000083290 ULK2 - 19768956 -
1 19770641,19771249,-0.218217890236
2 19769049,19769141,-1.00636292769
3 19768116,19768157,-0.737993368111
4 19753055,19753087,-0.0133448318556
5 19752682,19752718,-0.358192041357
6 19750050,19750223,-0.273878970921
7 19748617,19748690,-0.088162847883
8 19746434,19746535,-0.0399628447329
9 19744802,19744860,0.0203875352017
10 19741814,19741896,-0.148956553759
11 19729452,19729499,-0.122528227552
12 19728407,19728495,0.25224953031
13 19720062,19720233,-0.933138949632
14 19713691,19713751,0.293840438991
15 19708006,19708143,0.089826267105
16 19705090,19705235,-0.0894836314736
17 19702808,19702888,0.0209262830808
18 19700709,19700995,-0.0998118416406
19 19699408,19699595,-0.581914373963
20 19698935,19699038,0.0580999938876
21 19689250,19689399,-0.145679006529
22 19687010,19687218,0.113141497729
23 19685202,19685380,0.133191619312
24 19684299,19684417,0.425414416472
25 19683785,19683942,0.334668536512
26 19680894,19681029,0.267610802961
27 19679622,19679720,-0.298511157063
28 19674143,19674380,-0.596196475138
ENSG00000065675 PRKCQ - 6584565 +
1 6622173,6622263,-0.530281060691
2 6556980,6557106,-0.632284962063
3 6552957,6553156,-0.54136434314
4 6549398,6549458,-0.581810520044
5 6540358,6540520,-0.571063273502
6 6539182,6539213,-0.591452355234
7 6538997,6539082,-0.606197729181
8 6533645,6533774,-0.66439290649
9 6527997,6528106,-0.592499311674
10 6527114,6527231,-0.605737135917
11 6525402,6525562,-0.599494146932
12 6520954,6521127,-0.587494011963
13 6506275,6506366,-0.547822170593
14 6504265,6504327,-0.568736248817
15 6498636,6498774,-0.605030192545
16 6483855,6484043,-0.575022611536
17 6472772,6472900,-0.566295527583
18 6469105,6470324,-0.545479126787
The key to using this data (although, again, you're probably going to end up doing something different than taking zscores, but they're here if you need them) is to use the breakpoint for the gene to split the array of zscores. So for example, in the last gene listed here, you'll see after the gene name and orientation, the number 6584565. That's the location on this gene where it's splitting and recombining with the first gene listed. Now look at the locations of all the exons. You'll notice that exon 1 is above that breakpoint and the rest of them are below that. So the T-test will compare the difference of the set of zscores between those two sides. Again, this is why T-test is super not good. You're comparing 1 datum to 17 other data points. Such unbalance. Much bad. What to do? This is the biggest issue with the data.
Evaluate.pvalueStats() and Evaluate.MasterList() use the zscores from these files and a T-test across the breakpoints of the individual genes and sorts by pvalue. pvalueStats() is for each individual cancer type, MasterList will collect all of the data for you and create a list, sorted by best (most likely candidates) first. Essentially how the tests are considered is this: in one gene fusion, you'll have two T-tests done; one on the first gene across its breakpoint (which will have a resulting pvalue) and the second on the other gene, also with a resulting pvalue. Because only one gene in a fusion is all that's required to be a driver (for instance, if gene A is a driver, you could have fusions A-B, A-L, A-P etc all being oncogenic) we take the best p value of the two and assign the entire fusion that best score. My current top 10 list after running this script (and waiting a long time for it to complete) looks like this.
#columns: first_gene, second_gene, best_pvalue_of_the_two, cancer type
ALK TRPC4AP 0.0001 LUAD
SLC7A6 PRKCA 0.00016 LUSC
KDELC2 SIK2 0.00016 LUSC
GPR116 MIOS 0.00019 LUAD
RAP1GDS1 NPNT 0.00021 LUAD
GANC PDE8A 0.00022 LUAD
FARP2 ABCB4 0.00022 HNSC
CAPRIN2 PPM1L 0.00024 HNSC
MAP3K3 SCN4A 0.00025 HNSC
C14orf39 PCLO 0.00028 LUSC
That's about as much as I think I can include to get you started. Feel free to email me at collinol@uchicago.edu for questions or clarifications. Like I said, I suspect your main goal that Dr. Yang will task you with will be to develop a better method of scoring the fusions. If you need help reconfiguring the files or maybe getting some data somewhere along the process that I didn't include, let me know. I should be able to find it for you so you don't have to waste time looking through csv columns.
Additionally, for better statistical tests, I suspect that will be the major focus of your work. Deciding which tests you think would work best, given the nature of the data. My research ended before I could continue with that, so I don't have all the answers. However, before I stopped working on it, I was looking at changing the t-test over to variance analysis like you mentioned. Specifically, ANOVA (analysis of variance) test. There's some good documentation on it here http://www.statisticshowto.com/probability-and-statistics/hypothesis-testing/anova/#HowToRun. It most likely won't be a perfect fit, but there's already python libraries for it https://plot.ly/python/anova/. So it should be relatively quick to implement and see what results you get.
Beyond pre-built stats packages, there are known driver fusions (ERG-TMPRSS2, BCR-ABL, ALK-(with lots of others), etc). I'm not sure how familiar you are with machine learning techniques, but if you have the time to invest into it, it could be a good approach to collect the data from the current scripts regarding only the exon values for known gene fusions, split that information into a training and testing group, and then see if you can develop a model to accurately classify the test data. I'd start with binary classification (known fusions, unknown fusions) and then get more specific as to what the actual gene fusion is.
Good luck!
Collin Olander