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AD progresses gradually, yet most transcriptomic classifiers treat it as binary. I built a 1D CNN and trained it on hippocampal RNA-seq from 172 5xFAD/3xTgAD mice (4–18mo) with disease and age heads, achieving 0.974 AUROC (LOGO-CV). Since both models use Thy1 promoters, I ran ablations and multi-seed attribution to test for transgene artifacts.