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Updated PyChromVar#18

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ianlatch wants to merge 5 commits into
pinellolab:mainfrom
ianlatch:main
Open

Updated PyChromVar#18
ianlatch wants to merge 5 commits into
pinellolab:mainfrom
ianlatch:main

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@ianlatch

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Added several new features and performance improvements.

Should be now a little bit closer to the actual ChromVar R package. Not fully, but a start.

ianlatch added 5 commits June 16, 2026 15:47
Added:
- get_bg_peaks (deterministic KNN for chromVAR's real binned gaussian
  weighed sampling)
- compute_deviations (now emits z-scores and deviations + QC) also fixed
  background to reoder cound cols
- match_motif (implemented TODO sub there)

Deps:
- added pytest and pytest-xdist, dropped pynndescent, removed deprecated
  anndata APIs
- added compute variability
- added differential variability/differential deviations
- added some QC helpers

Improved Performance:
- compute_deviations (2x)
- get_bg_peaks (10x)
- compute_variability (4x)
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